IMP: Integrative Multi-species Prediction

Drosophila melanogaster

262 known processes

l(2)gl (Dmel_CG2671)

lethal (2) giant larvae

(Aliases: p127,l[[2]]gl,p127l(2)gl,lgl,Lgl,LGL,l(2),CG2671,L(2)gl,Dmel\CG2671,D-LGL,L(2)GL,l(2) giant larva,gl,l-gl,dlgl,MENE (2L)-B,l(2)giant larvae)

FLYBASE: FBgn0002121
Entrez: 33156
UniProtKB: P08111
UniProtKB: M9NCX1
UniProtKB: M9PBJ2

Process Predictions
Disease Predictions

l(2)gl biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
localization of cell	GO:0051674	257	0.999	Zebrafish
cell migration	GO:0016477	238	0.998	Zebrafish
digestive system development	GO:0055123	149	0.996
malpighian tubule development	GO:0072002	64	0.993
tube development	GO:0035295	244	0.990
axonogenesis	GO:0007409	290	0.989	Rat
female germ line cyst formation	GO:0048135	42	0.989
regulation of anatomical structure morphogenesis	GO:0022603	242	0.987	Zebrafish
regulation of growth	GO:0040008	233	0.987
establishment or maintenance of bipolar cell polarity	GO:0061245	34	0.986	Mouse
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.983
ovarian follicle cell migration	GO:0007297	121	0.981
tissue morphogenesis	GO:0048729	297	0.977
digestive tract morphogenesis	GO:0048546	127	0.974
regulation of multicellular organismal development	GO:2000026	414	0.973
malpighian tubule morphogenesis	GO:0007443	44	0.967
developmental growth	GO:0048589	280	0.967
axon guidance	GO:0007411	233	0.964
ameboidal type cell migration	GO:0001667	151	0.961
renal tubule development	GO:0061326	64	0.956
growth	GO:0040007	359	0.953
epithelial cell development	GO:0002064	274	0.952
border follicle cell migration	GO:0007298	113	0.950
cell motility	GO:0048870	251	0.950	Zebrafish
urogenital system development	GO:0001655	72	0.948
protein transport	GO:0015031	155	0.927
epithelial cell migration	GO:0010631	148	0.920
embryonic morphogenesis	GO:0048598	206	0.914
single organism cellular localization	GO:1902580	180	0.909
single organism nuclear import	GO:1902593	51	0.904
stem cell fate commitment	GO:0048865	25	0.903
tube morphogenesis	GO:0035239	191	0.902
neurological system process	GO:0050877	358	0.896	Fly
ovarian follicle cell development	GO:0030707	248	0.894
protein targeting	GO:0006605	64	0.891
single organism behavior	GO:0044708	391	0.889	Fly
meiotic nuclear division	GO:0007126	151	0.879
dna metabolic process	GO:0006259	227	0.872
regulation of developmental growth	GO:0048638	174	0.870
cell division	GO:0051301	248	0.867
establishment or maintenance of cell polarity	GO:0007163	167	0.867
immune system process	GO:0002376	347	0.866
renal tubule morphogenesis	GO:0061333	44	0.863
epithelium migration	GO:0090132	148	0.858
neuron projection guidance	GO:0097485	241	0.855
epithelial cell differentiation	GO:0030855	322	0.852
germarium derived female germ line cyst formation	GO:0030727	42	0.850
asymmetric cell division	GO:0008356	37	0.841
organic substance transport	GO:0071702	257	0.839
protein import into nucleus	GO:0006606	51	0.834
germarium derived egg chamber formation	GO:0007293	101	0.831
intracellular transport	GO:0046907	228	0.828	Rat
regulation of cell morphogenesis	GO:0022604	163	0.826	Zebrafish
dendrite morphogenesis	GO:0048813	199	0.824
regulation of cell projection organization	GO:0031344	92	0.824
single organism intracellular transport	GO:1902582	207	0.823	Rat
regulation of protein transport	GO:0051223	57	0.811
intracellular protein transport	GO:0006886	104	0.794
hindgut development	GO:0061525	58	0.793
embryonic development via the syncytial blastoderm	GO:0001700	148	0.780
mushroom body development	GO:0016319	70	0.773
regulation of cell proliferation	GO:0042127	163	0.765
establishment of protein localization	GO:0045184	163	0.764
meiotic cell cycle process	GO:1903046	132	0.764
regulation of neurogenesis	GO:0050767	158	0.763
regulation of dendrite morphogenesis	GO:0048814	28	0.752
segmentation	GO:0035282	207	0.749
cellular protein localization	GO:0034613	160	0.743
regulation of cell shape	GO:0008360	113	0.740
wnt signaling pathway	GO:0016055	98	0.734
digestive tract development	GO:0048565	149	0.727
dorsal appendage formation	GO:0046843	47	0.710
negative regulation of signal transduction	GO:0009968	206	0.709
regulation of cell differentiation	GO:0045595	302	0.704
regulation of notch signaling pathway	GO:0008593	100	0.700
stem cell division	GO:0017145	69	0.698
spermatogenesis	GO:0007283	200	0.697
chemotaxis	GO:0006935	249	0.695
stem cell proliferation	GO:0072089	88	0.694
chorion containing eggshell formation	GO:0007304	105	0.690
establishment or maintenance of apical basal cell polarity	GO:0035088	34	0.679	Mouse
hindgut morphogenesis	GO:0007442	58	0.676
regulation of vesicle mediated transport	GO:0060627	59	0.672
cytokinesis	GO:0000910	90	0.671
endomembrane system organization	GO:0010256	119	0.668
protein localization to nucleus	GO:0034504	55	0.658
membrane organization	GO:0061024	112	0.658
dendrite development	GO:0016358	204	0.654
tissue migration	GO:0090130	155	0.653
establishment of epithelial cell polarity	GO:0090162	13	0.640
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.639	Zebrafish
response to wounding	GO:0009611	94	0.632
cellular macromolecule localization	GO:0070727	220	0.617
adherens junction organization	GO:0034332	27	0.608
germ cell migration	GO:0008354	43	0.607
protein localization	GO:0008104	284	0.607
actin filament based process	GO:0030029	220	0.589
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.588
oocyte development	GO:0048599	124	0.580
chemosensory behavior	GO:0007635	106	0.569
establishment of protein localization to organelle	GO:0072594	62	0.560
establishment of localization in cell	GO:0051649	402	0.559	Rat
negative regulation of developmental process	GO:0051093	201	0.556
oocyte axis specification	GO:0007309	108	0.554
endocytosis	GO:0006897	310	0.548
actin cytoskeleton organization	GO:0030036	206	0.545
peripheral nervous system development	GO:0007422	52	0.543
single organism cell adhesion	GO:0098602	47	0.542
body morphogenesis	GO:0010171	2	0.538
protein localization to organelle	GO:0033365	82	0.527
programmed cell death	GO:0012501	257	0.523
homeostatic process	GO:0042592	199	0.521
regulation of protein localization	GO:0032880	76	0.517
cell projection assembly	GO:0030031	94	0.514	Zebrafish
heart field specification	GO:0003128	0	0.514
single organismal cell cell adhesion	GO:0016337	45	0.513
protein targeting to nucleus	GO:0044744	51	0.513
columnar cuboidal epithelial cell development	GO:0002066	249	0.510
negative regulation of apoptotic process	GO:0043066	63	0.508
neural precursor cell proliferation	GO:0061351	75	0.505
autophagy	GO:0006914	108	0.504
regulation of apoptotic process	GO:0042981	130	0.503
regulation of intracellular protein transport	GO:0033157	46	0.502
spermatid development	GO:0007286	98	0.498
negative regulation of cell cycle	GO:0045786	116	0.490
regulation of epithelial cell proliferation	GO:0050678	4	0.488	Zebrafish
apoptotic process	GO:0006915	159	0.481
regulation of neuron differentiation	GO:0045664	103	0.480
death	GO:0016265	284	0.474
immune system development	GO:0002520	57	0.454
mitotic spindle organization	GO:0007052	220	0.453
single organism membrane organization	GO:0044802	93	0.452
cell proliferation	GO:0008283	299	0.449
positive regulation of cell differentiation	GO:0045597	64	0.448
spindle organization	GO:0007051	253	0.435
gastrulation	GO:0007369	70	0.429
cytoplasmic transport	GO:0016482	130	0.419	Rat
asymmetric protein localization involved in cell fate determination	GO:0045167	9	0.416
germ line cyst formation	GO:0048134	44	0.412
chorion containing eggshell pattern formation	GO:0030381	11	0.412
axon development	GO:0061564	297	0.410	Rat
head development	GO:0060322	135	0.402
germarium derived oocyte fate determination	GO:0007294	26	0.402
synapse assembly	GO:0007416	143	0.402
sex differentiation	GO:0007548	81	0.401
regulation of protein import into nucleus	GO:0042306	28	0.397
negative regulation of epithelial cell proliferation	GO:0050680	4	0.395	Zebrafish
renal system development	GO:0072001	72	0.389
negative regulation of signaling	GO:0023057	219	0.386
regulation of intracellular transport	GO:0032386	64	0.379
regulation of axonogenesis	GO:0050770	32	0.375
regulation of nervous system development	GO:0051960	248	0.370
ovarian follicle cell stalk formation	GO:0030713	17	0.369
positive regulation of growth	GO:0045927	75	0.367
zonula adherens assembly	GO:0045186	6	0.361
mitotic cytokinesis	GO:0000281	50	0.359
eggshell formation	GO:0030703	105	0.356
protein phosphorylation	GO:0006468	169	0.353
positive regulation of cell size	GO:0045793	21	0.353
regulation of cellular component size	GO:0032535	98	0.344
regulation of nucleocytoplasmic transport	GO:0046822	35	0.344
olfactory behavior	GO:0042048	97	0.344
dorsal closure	GO:0007391	79	0.341
negative regulation of cell cell adhesion	GO:0022408	8	0.338
sensory organ precursor cell division	GO:0045035	10	0.333
delamination	GO:0060232	8	0.329
neuroblast proliferation	GO:0007405	74	0.327
reproductive structure development	GO:0048608	74	0.322
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.322
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	12	0.319
dna replication	GO:0006260	48	0.315
meiotic cell cycle	GO:0051321	171	0.313
morphogenesis of follicular epithelium	GO:0016333	36	0.312
cellular response to radiation	GO:0071478	52	0.311
negative regulation of programmed cell death	GO:0043069	72	0.308
development of primary sexual characteristics	GO:0045137	50	0.306
embryonic hindgut morphogenesis	GO:0048619	48	0.302
regulation of neuron projection development	GO:0010975	69	0.301
central nervous system development	GO:0007417	201	0.300
asymmetric protein localization	GO:0008105	33	0.296
regulation of programmed cell death	GO:0043067	152	0.295
morphogenesis of an epithelium	GO:0002009	276	0.291
oocyte microtubule cytoskeleton organization	GO:0016325	35	0.287
regulation of cellular localization	GO:0060341	136	0.283
regulation of cytoplasmic transport	GO:1903649	47	0.272
neuroblast fate commitment	GO:0014017	19	0.269
positive regulation of protein localization to nucleus	GO:1900182	21	0.266
male gamete generation	GO:0048232	201	0.263
organelle fission	GO:0048285	340	0.256
regulation of stress activated protein kinase signaling cascade	GO:0070302	42	0.254
mesoderm development	GO:0007498	78	0.254
cell fate determination	GO:0001709	91	0.254
i kappab kinase nf kappab signaling	GO:0007249	6	0.253
negative regulation of cellular component organization	GO:0051129	108	0.247	Zebrafish
taxis	GO:0042330	304	0.247
negative regulation of cell proliferation	GO:0008285	69	0.246
regionalization	GO:0003002	416	0.242
regulation of dendrite development	GO:0050773	37	0.241
axis specification	GO:0009798	167	0.240
protein modification process	GO:0036211	438	0.232
somatic stem cell maintenance	GO:0035019	14	0.230
organelle localization	GO:0051640	148	0.230
epithelial cell proliferation	GO:0050673	15	0.229	Zebrafish
stem cell differentiation	GO:0048863	117	0.224	Zebrafish
synaptic growth at neuromuscular junction	GO:0051124	119	0.224
regulation of cell development	GO:0060284	215	0.223
establishment of protein localization to plasma membrane	GO:0090002	9	0.222
protein import	GO:0017038	55	0.221
phosphorylation	GO:0016310	294	0.220
positive regulation of stem cell differentiation	GO:2000738	3	0.220
response to radiation	GO:0009314	155	0.218
hindbrain development	GO:0030902	2	0.213
nucleus localization	GO:0051647	34	0.207
germarium derived female germ line cyst encapsulation	GO:0030708	8	0.204
cuticle development	GO:0042335	86	0.204
actin filament organization	GO:0007015	126	0.203
transmembrane transport	GO:0055085	139	0.203
regulation of epithelial cell differentiation	GO:0030856	4	0.203
cell recognition	GO:0008037	102	0.191
eggshell chorion assembly	GO:0007306	66	0.191
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.187
epithelial tube morphogenesis	GO:0060562	88	0.187
biological adhesion	GO:0022610	138	0.183
regulation of anatomical structure size	GO:0090066	163	0.182
cell competition in a multicellular organism	GO:0035212	10	0.182
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.181
cellular ketone metabolic process	GO:0042180	24	0.181
response to starvation	GO:0042594	97	0.181
negative regulation of molecular function	GO:0044092	51	0.174
melanotic encapsulation of foreign target	GO:0035011	30	0.173
determination of adult lifespan	GO:0008340	137	0.173
embryonic organ development	GO:0048568	50	0.173
dorsal closure spreading of leading edge cells	GO:0007395	4	0.172
cytoskeleton dependent cytokinesis	GO:0061640	81	0.171
humoral immune response	GO:0006959	117	0.170
negative regulation of cellular metabolic process	GO:0031324	382	0.169
r3 r4 cell differentiation	GO:0048056	12	0.168
regulation of catabolic process	GO:0009894	170	0.167	Rat
multicellular organismal aging	GO:0010259	140	0.167
regulation of establishment of protein localization	GO:0070201	61	0.164
macromolecular complex assembly	GO:0065003	256	0.161	Human
regulation of protein metabolic process	GO:0051246	256	0.159
embryonic hemopoiesis	GO:0035162	26	0.158
filopodium assembly	GO:0046847	33	0.158
somatic stem cell division	GO:0048103	37	0.157
imaginal disc derived leg morphogenesis	GO:0007480	80	0.153
pericardium morphogenesis	GO:0003344	2	0.153
cell junction assembly	GO:0034329	42	0.150	Zebrafish
regulation of cell cell adhesion	GO:0022407	21	0.149
hematopoietic or lymphoid organ development	GO:0048534	57	0.147
larval development	GO:0002164	104	0.146
endosomal transport	GO:0016197	44	0.145
regulation of cell projection assembly	GO:0060491	30	0.145
forebrain development	GO:0030900	2	0.144
peptidyl amino acid modification	GO:0018193	105	0.143
nucleocytoplasmic transport	GO:0006913	72	0.142
regulation of transport	GO:0051049	181	0.141
morphogenesis of embryonic epithelium	GO:0016331	94	0.140
imaginal disc derived leg joint morphogenesis	GO:0016348	15	0.140
regulation of protein localization to nucleus	GO:1900180	29	0.138
reproductive system development	GO:0061458	74	0.138
epithelial cell cell adhesion	GO:0090136	6	0.138
cellular response to abiotic stimulus	GO:0071214	58	0.136
nuclear import	GO:0051170	51	0.135
nuclear division	GO:0000280	332	0.134
morphogenesis of a polarized epithelium	GO:0001738	93	0.134
oocyte localization involved in germarium derived egg chamber formation	GO:0030720	12	0.133
cellular response to chemical stimulus	GO:0070887	199	0.132
neuron death	GO:0070997	27	0.132
cellular response to nutrient levels	GO:0031669	62	0.131
neuron recognition	GO:0008038	101	0.131
regulation of molecular function	GO:0065009	217	0.131
i kappab phosphorylation	GO:0007252	3	0.128
neuroblast fate determination	GO:0007400	12	0.128
negative regulation of nervous system development	GO:0051961	92	0.128
positive regulation of developmental process	GO:0051094	143	0.125
adherens junction assembly	GO:0034333	11	0.125
establishment of nucleus localization	GO:0040023	26	0.122
regulation of transferase activity	GO:0051338	58	0.122
regulation of intracellular signal transduction	GO:1902531	236	0.122	Rat
photoreceptor cell development	GO:0042461	96	0.121
male sex differentiation	GO:0046661	25	0.120
vesicle mediated transport	GO:0016192	381	0.119	Rat
centrosome cycle	GO:0007098	137	0.115
oocyte construction	GO:0007308	112	0.114
eye development	GO:0001654	323	0.113
positive regulation of rna metabolic process	GO:0051254	271	0.113
establishment of planar polarity	GO:0001736	87	0.112
negative regulation of cell differentiation	GO:0045596	143	0.110
positive regulation of developmental growth	GO:0048639	62	0.110
reproductive behavior	GO:0019098	122	0.110
negative regulation of cell death	GO:0060548	81	0.108
stem cell maintenance	GO:0019827	67	0.108
polarity specification of anterior posterior axis	GO:0009949	5	0.107
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.107
regulation of tube diameter	GO:0035296	14	0.105
multicellular organism growth	GO:0035264	46	0.105
cellular protein modification process	GO:0006464	438	0.104
cardiac muscle tissue development	GO:0048738	9	0.102
spermatid differentiation	GO:0048515	114	0.102
stem cell development	GO:0048864	79	0.101	Zebrafish
branching morphogenesis of an epithelial tube	GO:0048754	45	0.100
maintenance of location	GO:0051235	73	0.099
positive regulation of pathway restricted smad protein phosphorylation	GO:0010862	1	0.098
pericardium development	GO:0060039	2	0.097
extracellular structure organization	GO:0043062	46	0.095
negative regulation of cell adhesion	GO:0007162	9	0.095
protein complex biogenesis	GO:0070271	201	0.095	Human
regulation of protein modification process	GO:0031399	112	0.094
regulation of cytoskeleton organization	GO:0051493	89	0.094
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.094
regulation of protein targeting	GO:1903533	29	0.093
organ growth	GO:0035265	56	0.092
nephron tubule morphogenesis	GO:0072078	3	0.092
catabolic process	GO:0009056	409	0.092	Rat
cell death	GO:0008219	279	0.091
regulation of phosphorylation	GO:0042325	147	0.091
larval lymph gland hemopoiesis	GO:0035167	17	0.090
organelle assembly	GO:0070925	198	0.090	Zebrafish
asymmetric neuroblast division	GO:0055059	33	0.090
genitalia morphogenesis	GO:0035112	16	0.089
plasma membrane organization	GO:0007009	26	0.089
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.089
malpighian tubule tip cell differentiation	GO:0061382	9	0.088
positive regulation of response to stimulus	GO:0048584	323	0.088
cellular amino acid metabolic process	GO:0006520	61	0.087
embryo development ending in birth or egg hatching	GO:0009792	152	0.086
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.086
compound eye photoreceptor cell differentiation	GO:0001751	140	0.086
cell growth	GO:0016049	108	0.086
response to organic substance	GO:0010033	284	0.085
regulation of malpighian tubule diameter	GO:0035297	3	0.085
negative regulation of gtpase activity	GO:0034260	1	0.084
cell cell junction organization	GO:0045216	55	0.083
protein localization to plasma membrane	GO:0072659	13	0.082
regulation of phosphate metabolic process	GO:0019220	210	0.082
cell cycle dna replication	GO:0044786	23	0.082
cellular response to starvation	GO:0009267	61	0.081
regulation of compound eye retinal cell programmed cell death	GO:0046669	18	0.081
gliogenesis	GO:0042063	80	0.080
establishment of ommatidial planar polarity	GO:0042067	49	0.079
transcription from rna polymerase ii promoter	GO:0006366	368	0.079
regulation of actin cytoskeleton organization	GO:0032956	42	0.079
chemical homeostasis	GO:0048878	92	0.079
kidney development	GO:0001822	3	0.078
cell rearrangement involved in malpighian tubule morphogenesis	GO:0061334	3	0.078
positive regulation of transport	GO:0051050	92	0.077
cellular component assembly involved in morphogenesis	GO:0010927	151	0.076	Zebrafish
nephron development	GO:0072006	3	0.075
cell fate specification	GO:0001708	71	0.075
myotube cell development	GO:0014904	3	0.075
positive regulation of intracellular protein transport	GO:0090316	30	0.074
bmp signaling pathway involved in malpighian tubule cell chemotaxis	GO:0061353	3	0.074
skin development	GO:0043588	65	0.073
cell surface receptor signaling pathway involved in heart development	GO:0061311	3	0.073
anterior posterior pattern specification	GO:0009952	136	0.071
maintenance of cell polarity	GO:0030011	18	0.071	Mouse
photoreceptor cell differentiation	GO:0046530	170	0.071
negative regulation of mitotic cell cycle	GO:0045930	109	0.071
dormancy process	GO:0022611	2	0.070
nuclear transport	GO:0051169	72	0.070
cellular macromolecular complex assembly	GO:0034622	153	0.068
regulation of heart morphogenesis	GO:2000826	3	0.068
regulation of synapse assembly	GO:0051963	94	0.067
establishment of mitotic spindle localization	GO:0040001	17	0.066
negative regulation of rna metabolic process	GO:0051253	251	0.065
retinal cell programmed cell death	GO:0046666	25	0.065
positive regulation of cell migration	GO:0030335	2	0.065
ion transmembrane transport	GO:0034220	122	0.065
negative regulation of notch signaling pathway	GO:0045746	41	0.064
guanosine containing compound catabolic process	GO:1901069	74	0.064	Rat
positive regulation of protein transport	GO:0051222	37	0.063
cellular protein complex assembly	GO:0043623	71	0.063
negative regulation of transforming growth factor beta receptor signaling pathway	GO:0030512	4	0.063
mitotic nuclear division	GO:0007067	213	0.062
organic acid metabolic process	GO:0006082	103	0.062
negative regulation of wnt signaling pathway	GO:0030178	28	0.061
embryonic pattern specification	GO:0009880	174	0.061
heart development	GO:0007507	82	0.061
assembly of actomyosin apparatus involved in cytokinesis	GO:0000912	11	0.061
regulation of immune system process	GO:0002682	176	0.061
negative regulation of cell communication	GO:0010648	223	0.061
small molecule metabolic process	GO:0044281	305	0.059	Rat
positive regulation of phosphorus metabolic process	GO:0010562	139	0.059	Rat
compound eye morphogenesis	GO:0001745	249	0.059
positive regulation of neurogenesis	GO:0050769	41	0.059
response to organic cyclic compound	GO:0014070	89	0.058
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.057
oocyte morphogenesis	GO:0048601	3	0.057
wound healing	GO:0042060	75	0.056
actin cytoskeleton reorganization	GO:0031532	22	0.056
muscle structure development	GO:0061061	224	0.056
oxoacid metabolic process	GO:0043436	103	0.056
cell cycle checkpoint	GO:0000075	95	0.056
negative regulation of neural precursor cell proliferation	GO:2000178	27	0.056
compound eye retinal cell programmed cell death	GO:0046667	23	0.056
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.055
cell adhesion	GO:0007155	136	0.055
positive regulation of signal transduction	GO:0009967	223	0.054
hemopoiesis	GO:0030097	46	0.054
response to extracellular stimulus	GO:0009991	116	0.054
carbohydrate derivative catabolic process	GO:1901136	118	0.053	Rat
regulation of ras protein signal transduction	GO:0046578	93	0.053	Rat
eye morphogenesis	GO:0048592	260	0.052
regulation of microtubule based process	GO:0032886	49	0.052
cation homeostasis	GO:0055080	51	0.051
striated muscle tissue development	GO:0014706	27	0.051
female meiotic division	GO:0007143	70	0.051
positive regulation of rna biosynthetic process	GO:1902680	266	0.049
cell elongation involved in imaginal disc derived wing morphogenesis	GO:0090254	5	0.048
protein polymerization	GO:0051258	42	0.048
kidney epithelium development	GO:0072073	3	0.048
regulation of cell size	GO:0008361	63	0.048
cellular response to extracellular stimulus	GO:0031668	64	0.048
motor neuron axon guidance	GO:0008045	58	0.047
transforming growth factor beta receptor signaling pathway	GO:0007179	16	0.047
neuroblast differentiation	GO:0014016	29	0.046
ovarian nurse cell to oocyte transport	GO:0007300	27	0.046
positive regulation of protein kinase activity	GO:0045860	25	0.046
lipid metabolic process	GO:0006629	121	0.046
purine nucleoside metabolic process	GO:0042278	127	0.046	Rat
positive regulation of phosphorylation	GO:0042327	87	0.046
establishment of organelle localization	GO:0051656	122	0.045
cell maturation	GO:0048469	144	0.045
mesenchymal cell differentiation	GO:0048762	1	0.045	Zebrafish
regulation of filopodium assembly	GO:0051489	24	0.045
developmental maturation	GO:0021700	172	0.045
morphogenesis of a branching structure	GO:0001763	45	0.044
negative regulation of epithelial cell migration	GO:0010633	1	0.044
regulation of dna replication	GO:0006275	13	0.044
regulation of epidermal cell differentiation	GO:0045604	3	0.044
blastoderm segmentation	GO:0007350	159	0.044
heterocycle catabolic process	GO:0046700	166	0.044	Rat
regulation of cellular amino acid metabolic process	GO:0006521	0	0.043
cell activation	GO:0001775	9	0.043
skeletal muscle fiber development	GO:0048741	3	0.042
positive regulation of mitotic cell cycle	GO:0045931	34	0.042
cardiac cell fate commitment	GO:0060911	17	0.042
negative regulation of intrinsic apoptotic signaling pathway	GO:2001243	1	0.041
brain development	GO:0007420	120	0.041
cellular response to organic substance	GO:0071310	132	0.041
nephron epithelium development	GO:0072009	3	0.041
maintenance of protein location in cell	GO:0032507	26	0.041
regulation of glial cell proliferation	GO:0060251	11	0.041
imaginal disc derived wing hair organization	GO:0035317	45	0.041
centrosome organization	GO:0051297	163	0.040
regulation of protein phosphorylation	GO:0001932	64	0.040
regulation of mitotic cell cycle	GO:0007346	190	0.040
carboxylic acid metabolic process	GO:0019752	92	0.040
regulation of mitosis	GO:0007088	56	0.039
respiratory system development	GO:0060541	213	0.039
nucleoside catabolic process	GO:0009164	112	0.038	Rat
dorsal closure elongation of leading edge cells	GO:0007394	10	0.038
positive regulation of multicellular organismal process	GO:0051240	143	0.038
r3 r4 cell fate commitment	GO:0007464	10	0.038
maternal determination of dorsal ventral axis ovarian follicular epithelium soma encoded	GO:0008071	1	0.038
epithelial cell fate determination open tracheal system	GO:0007425	2	0.038
appendage morphogenesis	GO:0035107	397	0.038
positive regulation of signaling	GO:0023056	243	0.038
oviposition	GO:0018991	19	0.038
stress activated protein kinase signaling cascade	GO:0031098	55	0.038
establishment or maintenance of epithelial cell apical basal polarity	GO:0045197	24	0.037
glial cell fate determination	GO:0007403	3	0.037
zygotic specification of dorsal ventral axis	GO:0007352	3	0.037
positive regulation of multicellular organism growth	GO:0040018	21	0.037
maintenance of apical basal cell polarity	GO:0035090	8	0.037	Mouse
canonical wnt signaling pathway	GO:0060070	21	0.037
regulation of multicellular organism growth	GO:0040014	40	0.037
meiotic dna repair synthesis	GO:0000711	3	0.037
positive regulation of intracellular transport	GO:0032388	42	0.036
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	18	0.036
dendrite regeneration	GO:0031104	2	0.036
regulation of cell cycle process	GO:0010564	181	0.036
leg disc morphogenesis	GO:0007478	80	0.036
cell cycle g1 s phase transition	GO:0044843	31	0.036
positive regulation of macromolecule metabolic process	GO:0010604	405	0.036
regulation of endocytosis	GO:0030100	37	0.036
regulation of cell cycle	GO:0051726	291	0.036
organic substance catabolic process	GO:1901575	308	0.035	Rat
defense response	GO:0006952	300	0.035
negative regulation of cell development	GO:0010721	62	0.035
regulation of cell proliferation involved in compound eye morphogenesis	GO:2000495	2	0.035
multi organism behavior	GO:0051705	175	0.035
phagocytosis	GO:0006909	215	0.034
regulation of jnk cascade	GO:0046328	40	0.034
regulation of organelle organization	GO:0033043	196	0.034
hemocyte differentiation	GO:0042386	38	0.034
cation transport	GO:0006812	110	0.034
regulation of dna metabolic process	GO:0051052	34	0.034
imaginal disc growth	GO:0007446	37	0.034
defense response to bacterium	GO:0042742	178	0.034
spinal cord development	GO:0021510	1	0.034

l(2)gl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.077
musculoskeletal system disease	DOID:17	0.077
brachydactyly	DOID:0050581	0.077
bone disease	DOID:0080001	0.077
bone development disease	DOID:0080006	0.077
connective tissue disease	DOID:65	0.077
dysostosis	DOID:1934	0.077

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