IMP: Integrative Multi-species Prediction

Drosophila melanogaster

124 known processes

hyx (Dmel_CG11990)

hyrax

(Aliases: Hyx,CG11990,Dmel\CG11990)

FLYBASE: FBgn0037657
Entrez: 41086
UniProtKB: Q9VHI1

Process Predictions
Disease Predictions

hyx biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
tube development	GO:0035295	244	0.684	Mouse
neural precursor cell proliferation	GO:0061351	75	0.499
chromatin modification	GO:0016568	147	0.402	Human
transcription from rna polymerase ii promoter	GO:0006366	368	0.400	Human Zebrafish Mouse
spermatid differentiation	GO:0048515	114	0.387
positive regulation of macromolecule metabolic process	GO:0010604	405	0.386
digestive system development	GO:0055123	149	0.378	Mouse
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.305
regulation of organelle organization	GO:0033043	196	0.271
neuroblast proliferation	GO:0007405	74	0.270
wing disc morphogenesis	GO:0007472	344	0.267
positive regulation of rna metabolic process	GO:0051254	271	0.253
developmental growth	GO:0048589	280	0.229
positive regulation of cellular component organization	GO:0051130	156	0.228
regulation of developmental growth	GO:0048638	174	0.221
vesicle mediated transport	GO:0016192	381	0.201
compound eye development	GO:0048749	307	0.196
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.193	Human Mouse
digestive tract morphogenesis	GO:0048546	127	0.186	Mouse
endocytosis	GO:0006897	310	0.180
positive regulation of rna biosynthetic process	GO:1902680	266	0.175
negative regulation of signaling	GO:0023057	219	0.160
regulation of phosphate metabolic process	GO:0019220	210	0.157
regulation of protein metabolic process	GO:0051246	256	0.154
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.152	Human Mouse
negative regulation of signal transduction	GO:0009968	206	0.149
regulation of nervous system development	GO:0051960	248	0.138
small molecule metabolic process	GO:0044281	305	0.136
growth	GO:0040007	359	0.135
organelle fission	GO:0048285	340	0.133
regulation of cell cycle process	GO:0010564	181	0.132	Human
positive regulation of transcription dna templated	GO:0045893	266	0.130
regulation of cell proliferation	GO:0042127	163	0.127	Human
regulation of transport	GO:0051049	181	0.121
regionalization	GO:0003002	416	0.120
regulation of phosphorus metabolic process	GO:0051174	210	0.120
establishment of localization in cell	GO:0051649	402	0.119
regulation of intracellular transport	GO:0032386	64	0.114
localization of cell	GO:0051674	257	0.113
nuclear transport	GO:0051169	72	0.113
gene silencing	GO:0016458	138	0.111
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.110
stem cell proliferation	GO:0072089	88	0.102
mesenchymal cell differentiation	GO:0048762	1	0.101
intracellular signal transduction	GO:0035556	300	0.097
positive regulation of cellular biosynthetic process	GO:0031328	316	0.096
phosphorylation	GO:0016310	294	0.096
wnt signaling pathway	GO:0016055	98	0.095
cell motility	GO:0048870	251	0.094
protein targeting to nucleus	GO:0044744	51	0.090
mitotic spindle organization	GO:0007052	220	0.090
male gamete generation	GO:0048232	201	0.090
nucleocytoplasmic transport	GO:0006913	72	0.090
regulation of meiosis	GO:0040020	3	0.089
regulation of dna templated transcription elongation	GO:0032784	17	0.088	Human Zebrafish
regulation of cell differentiation	GO:0045595	302	0.087	Human Mouse
peptidyl lysine modification	GO:0018205	57	0.086
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.086
retina development in camera type eye	GO:0060041	4	0.085
rna localization	GO:0006403	115	0.084
negative regulation of response to stimulus	GO:0048585	258	0.083
stem cell maintenance	GO:0019827	67	0.081	Mouse
defense response	GO:0006952	300	0.081
regulation of nuclear division	GO:0051783	58	0.080
dna templated transcription elongation	GO:0006354	18	0.079	Human Zebrafish
regulation of cytoplasmic transport	GO:1903649	47	0.078
protein modification process	GO:0036211	438	0.076	Human
histone modification	GO:0016570	106	0.074	Human
cell migration	GO:0016477	238	0.073
gene silencing by rna	GO:0031047	57	0.073
meiotic cell cycle	GO:0051321	171	0.071
negative regulation of biosynthetic process	GO:0009890	277	0.068	Human Mouse
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.068	Human Zebrafish Mouse
cell proliferation	GO:0008283	299	0.067	Human
positive regulation of organelle organization	GO:0010638	65	0.067
camera type eye morphogenesis	GO:0048593	2	0.067
appendage development	GO:0048736	401	0.066
nuclear import	GO:0051170	51	0.065
regulation of cellular catabolic process	GO:0031329	157	0.065
anatomical structure homeostasis	GO:0060249	97	0.064
positive regulation of molecular function	GO:0044093	136	0.062
nuclear division	GO:0000280	332	0.062
negative regulation of developmental process	GO:0051093	201	0.062	Human Mouse
regulation of chromatin modification	GO:1903308	28	0.061
organonitrogen compound metabolic process	GO:1901564	318	0.061
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.061
chromatin organization	GO:0006325	207	0.061	Human
cellular amine metabolic process	GO:0044106	12	0.059
spermatogenesis	GO:0007283	200	0.059
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.058	Human Mouse
spindle organization	GO:0007051	253	0.057
cell cycle phase transition	GO:0044770	140	0.057	Human
eye development	GO:0001654	323	0.056
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.055	Human
negative regulation of cell communication	GO:0010648	223	0.055
regulation of phosphorylation	GO:0042325	147	0.054
posttranscriptional gene silencing by rna	GO:0035194	45	0.054
meiotic nuclear division	GO:0007126	151	0.054
cytoplasmic transport	GO:0016482	130	0.052
cell division	GO:0051301	248	0.051
notch signaling pathway	GO:0007219	120	0.051
single organism intracellular transport	GO:1902582	207	0.050
cellular macromolecular complex assembly	GO:0034622	153	0.050
macromolecular complex assembly	GO:0065003	256	0.050
regulation of growth	GO:0040008	233	0.050
meiotic cell cycle process	GO:1903046	132	0.049
regulation of localization	GO:0032879	275	0.048
dna metabolic process	GO:0006259	227	0.048
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.047
cell growth	GO:0016049	108	0.047
positive regulation of developmental growth	GO:0048639	62	0.047
detection of stimulus involved in sensory perception	GO:0050906	92	0.043
regulation of notch signaling pathway	GO:0008593	100	0.043
homeostatic process	GO:0042592	199	0.043	Zebrafish
posttranscriptional gene silencing	GO:0016441	46	0.042
protein import	GO:0017038	55	0.042
cellular protein localization	GO:0034613	160	0.041
regulation of behavior	GO:0050795	75	0.041
post embryonic appendage morphogenesis	GO:0035120	385	0.041
regulation of chromosome organization	GO:0033044	64	0.040
regulation of gene expression epigenetic	GO:0040029	128	0.040
locomotory behavior	GO:0007626	176	0.040
single organism cellular localization	GO:1902580	180	0.040
mrna metabolic process	GO:0016071	124	0.040	Human
regulation of cellular localization	GO:0060341	136	0.039
phagocytosis	GO:0006909	215	0.039
pigmentation	GO:0043473	75	0.039
regulation of protein modification process	GO:0031399	112	0.039
positive regulation of developmental process	GO:0051094	143	0.038
positive regulation of signaling	GO:0023056	243	0.038
developmental cell growth	GO:0048588	52	0.038
positive regulation of multicellular organismal process	GO:0051240	143	0.037
camera type eye development	GO:0043010	4	0.037
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.036
digestive tract development	GO:0048565	149	0.036	Mouse
humoral immune response	GO:0006959	117	0.036
imaginal disc derived appendage development	GO:0048737	399	0.035
mapk cascade	GO:0000165	107	0.034
cellular ketone metabolic process	GO:0042180	24	0.033
positive regulation of signal transduction	GO:0009967	223	0.033
negative regulation of transcription dna templated	GO:0045892	237	0.033	Human Mouse
negative regulation of rna biosynthetic process	GO:1902679	240	0.033	Human Mouse
cellular macromolecule catabolic process	GO:0044265	136	0.032
chromosome organization	GO:0051276	360	0.032	Human
intracellular transport	GO:0046907	228	0.032
tube morphogenesis	GO:0035239	191	0.031	Mouse
regulation of cellular protein metabolic process	GO:0032268	243	0.031
regulation of mapk cascade	GO:0043408	92	0.031
proteolysis	GO:0006508	192	0.030
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	73	0.030
rna polyadenylation	GO:0043631	12	0.030	Human
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.029
imaginal disc derived wing margin morphogenesis	GO:0008587	41	0.029
positive regulation of biosynthetic process	GO:0009891	316	0.029
response to external biotic stimulus	GO:0043207	293	0.029	Mouse
protein import into nucleus	GO:0006606	51	0.027
regulation of intracellular signal transduction	GO:1902531	236	0.027
epithelial cell differentiation	GO:0030855	322	0.027
negative regulation of phosphate metabolic process	GO:0045936	45	0.027
regulation of cell cycle	GO:0051726	291	0.026	Human
amine metabolic process	GO:0009308	12	0.026
rna processing	GO:0006396	147	0.026	Human
regulation of chromatin organization	GO:1902275	32	0.026
imaginal disc pattern formation	GO:0007447	91	0.026
regulation of ras protein signal transduction	GO:0046578	93	0.026
positive regulation of phosphate metabolic process	GO:0045937	139	0.026
protein localization to nucleus	GO:0034504	55	0.026
positive regulation of transport	GO:0051050	92	0.025
nephron tubule development	GO:0072080	3	0.025
gland development	GO:0048732	191	0.025
positive regulation of cellular protein metabolic process	GO:0032270	118	0.025
organic substance transport	GO:0071702	257	0.025
gliogenesis	GO:0042063	80	0.025	Zebrafish
regulation of multicellular organism growth	GO:0040014	40	0.025
positive regulation of cell communication	GO:0010647	250	0.025
single organism behavior	GO:0044708	391	0.024
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.024	Human Mouse
dna templated transcription initiation	GO:0006352	25	0.024
eye morphogenesis	GO:0048592	260	0.024
single organism biosynthetic process	GO:0044711	206	0.024
negative regulation of gene expression	GO:0010629	387	0.024	Human Mouse
dorsal ventral pattern formation	GO:0009953	133	0.023
response to abiotic stimulus	GO:0009628	341	0.023
retina morphogenesis in camera type eye	GO:0060042	2	0.023
mrna processing	GO:0006397	104	0.022	Human
adult behavior	GO:0030534	137	0.022
gastrulation	GO:0007369	70	0.022	Mouse
negative regulation of protein metabolic process	GO:0051248	85	0.022
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.022
cellular amino acid metabolic process	GO:0006520	61	0.022
stem cell development	GO:0048864	79	0.021	Mouse
regulation of protein acetylation	GO:1901983	7	0.021
neuronal stem cell division	GO:0036445	35	0.021
regulation of neurogenesis	GO:0050767	158	0.021
nephron epithelium development	GO:0072009	3	0.021
establishment of protein localization to organelle	GO:0072594	62	0.021
ribonucleoprotein complex assembly	GO:0022618	23	0.021
protein maturation	GO:0051604	71	0.020
regulation of molecular function	GO:0065009	217	0.020
rhythmic process	GO:0048511	106	0.020
regulation of intracellular protein transport	GO:0033157	46	0.020
spermatid development	GO:0007286	98	0.020
nitrogen compound transport	GO:0071705	85	0.020
response to biotic stimulus	GO:0009607	294	0.019	Mouse
epithelial cell migration	GO:0010631	148	0.019
positive regulation of response to stimulus	GO:0048584	323	0.019
cell cycle arrest	GO:0007050	4	0.019
axis specification	GO:0009798	167	0.018
protein modification by small protein conjugation	GO:0032446	79	0.018	Human
transcription elongation from rna polymerase ii promoter	GO:0006368	18	0.018	Human Zebrafish
regulation of cellular ketone metabolic process	GO:0010565	3	0.018
exocrine system development	GO:0035272	162	0.018
embryonic morphogenesis	GO:0048598	206	0.018	Mouse
negative regulation of growth	GO:0045926	84	0.017
development of primary sexual characteristics	GO:0045137	50	0.017
carbohydrate derivative metabolic process	GO:1901135	217	0.017
protein targeting	GO:0006605	64	0.017
regulation of nucleocytoplasmic transport	GO:0046822	35	0.017
positive regulation of gene expression	GO:0010628	290	0.017
negative regulation of rna metabolic process	GO:0051253	251	0.016	Human Mouse
stem cell differentiation	GO:0048863	117	0.016	Mouse
macromolecule catabolic process	GO:0009057	161	0.016
body morphogenesis	GO:0010171	2	0.016
axon ensheathment	GO:0008366	10	0.015
positive regulation of intracellular transport	GO:0032388	42	0.015
mitotic spindle elongation	GO:0000022	81	0.015
protein catabolic process	GO:0030163	101	0.015
muscle organ development	GO:0007517	127	0.015
regulation of anatomical structure size	GO:0090066	163	0.015
small gtpase mediated signal transduction	GO:0007264	88	0.015
brain development	GO:0007420	120	0.015
immune system process	GO:0002376	347	0.015	Human Zebrafish
protein acetylation	GO:0006473	39	0.015
adult locomotory behavior	GO:0008344	76	0.015
ribonucleoprotein complex biogenesis	GO:0022613	31	0.014
hindbrain development	GO:0030902	2	0.014
regulation of membrane potential	GO:0042391	35	0.014
regulation of wnt signaling pathway	GO:0030111	68	0.014	Human
regulation of transcription factor import into nucleus	GO:0042990	22	0.014
axonogenesis	GO:0007409	290	0.014
establishment of rna localization	GO:0051236	47	0.014
negative regulation of nervous system development	GO:0051961	92	0.014
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.014
regulation of cellular amino acid metabolic process	GO:0006521	0	0.014
olfactory behavior	GO:0042048	97	0.014
negative regulation of cellular protein metabolic process	GO:0032269	85	0.014
appendage morphogenesis	GO:0035107	397	0.014
mesenchymal cell development	GO:0014031	1	0.013
mitotic nuclear division	GO:0007067	213	0.013
establishment of organelle localization	GO:0051656	122	0.013
single organism nuclear import	GO:1902593	51	0.013
nephron tubule morphogenesis	GO:0072078	3	0.013
regulation of cellular protein catabolic process	GO:1903362	44	0.013
negative regulation of cellular metabolic process	GO:0031324	382	0.013	Human Mouse
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.013	Human Mouse
signal transduction by phosphorylation	GO:0023014	107	0.013
chromatin remodeling	GO:0006338	72	0.013
dorsal ventral axis specification	GO:0009950	66	0.013
negative regulation of phosphorus metabolic process	GO:0010563	45	0.012
organic substance catabolic process	GO:1901575	308	0.012
nitric oxide metabolic process	GO:0046209	1	0.012
ras protein signal transduction	GO:0007265	88	0.012
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.012
peptide metabolic process	GO:0006518	80	0.012
synapse organization	GO:0050808	196	0.012
axon development	GO:0061564	297	0.012
nephron development	GO:0072006	3	0.012
carbohydrate derivative catabolic process	GO:1901136	118	0.012
embryo development ending in birth or egg hatching	GO:0009792	152	0.012	Worm
formation of primary germ layer	GO:0001704	24	0.012	Mouse
rna splicing	GO:0008380	83	0.012
intracellular protein transport	GO:0006886	104	0.012
negative regulation of cell cycle	GO:0045786	116	0.012	Human
positive regulation of catalytic activity	GO:0043085	118	0.012
muscle structure development	GO:0061061	224	0.012
sister chromatid segregation	GO:0000819	92	0.012
somatic stem cell division	GO:0048103	37	0.011
positive regulation of intracellular signal transduction	GO:1902533	116	0.011
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.011
axon guidance	GO:0007411	233	0.011
methylation	GO:0032259	47	0.011
regulation of circadian rhythm	GO:0042752	49	0.011
wing disc pattern formation	GO:0035222	66	0.011
regulation of nucleotide metabolic process	GO:0006140	62	0.011
circadian rhythm	GO:0007623	105	0.011
histone acetylation	GO:0016573	38	0.011
regulation of catabolic process	GO:0009894	170	0.011
nucleobase containing compound transport	GO:0015931	56	0.011
cellular catabolic process	GO:0044248	372	0.011
ubiquitin dependent protein catabolic process	GO:0006511	78	0.011
negative regulation of gene expression epigenetic	GO:0045814	77	0.011
internal peptidyl lysine acetylation	GO:0018393	38	0.011
imaginal disc derived wing morphogenesis	GO:0007476	337	0.011
cilium assembly	GO:0042384	38	0.011
regulation of protein localization to nucleus	GO:1900180	29	0.010
epithelial cell development	GO:0002064	274	0.010
oxoacid metabolic process	GO:0043436	103	0.010
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.010
instar larval development	GO:0002168	55	0.010
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.010
negative regulation of multicellular organismal process	GO:0051241	142	0.010	Human
neuromuscular junction development	GO:0007528	149	0.010
regulation of cell division	GO:0051302	72	0.010
aromatic compound catabolic process	GO:0019439	166	0.010
circulatory system development	GO:0072359	82	0.010	Zebrafish
reproductive structure development	GO:0048608	74	0.010
organonitrogen compound catabolic process	GO:1901565	128	0.010
internal protein amino acid acetylation	GO:0006475	38	0.010
pupal development	GO:0035209	11	0.010
positive regulation of mapk cascade	GO:0043410	63	0.010

hyx disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.050	Human

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