Drosophila melanogaster

85 known processes

Psn (Dmel_CG18803)

Presenilin

(Aliases: PS,Dmel\CG18803,PS1,DPS,dPsn,DrosPS,DmPS,psn,CG5868,l(3)77CDb,Dps,CG18803,pres,DPsn)

Psn biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
ovarian follicle cell developmentGO:00307072480.955
notch signaling pathwayGO:00072191200.943
open tracheal system developmentGO:00074242040.929
regulation of notch signaling pathwayGO:00085931000.816
regulation of erbb signaling pathwayGO:1901184420.795
Mouse
epithelial cell developmentGO:00020642740.707
regulation of epidermal growth factor receptor signaling pathwayGO:0042058420.702
Mouse
imaginal disc derived appendage morphogenesisGO:00351143950.682
enzyme linked receptor protein signaling pathwayGO:00071671790.661
Mouse Worm
salivary gland morphogenesisGO:00074351450.654
epidermal growth factor receptor signaling pathwayGO:0007173580.648
Mouse
positive regulation of response to stimulusGO:00485843230.613
Mouse Worm
programmed cell deathGO:00125012570.597
Human Mouse
single organism behaviorGO:00447083910.593
Mouse
compound eye morphogenesisGO:00017452490.534
appendage morphogenesisGO:00351073970.495
Mouse
segmentationGO:00352822070.492
Mouse
regulation of anatomical structure morphogenesisGO:00226032420.489
Mouse
axonogenesisGO:00074092900.470
Mouse
imaginal disc derived appendage developmentGO:00487373990.467
chromosome segregationGO:00070591570.457
protein modification processGO:00362114380.437
Mouse
camera type eye developmentGO:004301040.429
biological adhesionGO:00226101380.426
lateral inhibitionGO:00463312060.423
positive regulation of cell communicationGO:00106472500.420
Mouse Worm
negative regulation of erbb signaling pathwayGO:1901185290.419
Mouse
gland morphogenesisGO:00226121450.403
eye morphogenesisGO:00485922600.376
eye developmentGO:00016543230.365
epithelial cell differentiationGO:00308553220.359
Zebrafish
developmental pigmentationGO:0048066680.344
Zebrafish
striated muscle cell differentiationGO:0051146900.342
regulation of cell cycleGO:00517262910.336
protein localizationGO:00081042840.320
Mouse Worm
regionalizationGO:00030024160.306
actin filament based processGO:00300292200.297
tissue deathGO:00162711020.296
cell fate commitment involved in pattern specificationGO:0060581310.282
regulation of cellular localizationGO:00603411360.276
regulation of intracellular signal transductionGO:19025312360.268
Mouse
catabolic processGO:00090564090.267
Mouse
female germ line cyst formationGO:0048135420.265
organelle fissionGO:00482853400.263
cell adhesionGO:00071551360.262
striated muscle cell developmentGO:0055002500.258
phosphorylationGO:00163102940.253
Human Mouse
salivary gland developmentGO:00074311620.248
vesicle mediated transportGO:00161923810.247
Mouse
cell cell signaling involved in cell fate commitmentGO:00451682100.242
compound eye developmentGO:00487493070.230
regulation of vesicle mediated transportGO:0060627590.228
axon developmentGO:00615642970.220
Mouse
eggshell formationGO:00307031050.216
macromolecular complex assemblyGO:00650032560.212
Mouse
post embryonic appendage morphogenesisGO:00351203850.211
positive regulation of signal transductionGO:00099672230.210
Mouse Worm
columnar cuboidal epithelial cell differentiationGO:00020652560.209
Zebrafish
appendage developmentGO:00487364010.209
Mouse
positive regulation of macromolecule metabolic processGO:00106044050.209
Mouse
negative regulation of signalingGO:00230572190.186
Mouse
sensory organ boundary specificationGO:0008052220.186
establishment or maintenance of cell polarityGO:00071631670.185
apoptotic processGO:00069151590.180
Human Mouse
skeletal muscle organ developmentGO:0060538480.178
negative regulation of cell communicationGO:00106482230.177
Mouse
sensory organ morphogenesisGO:00905962600.176
regulation of endocytosisGO:0030100370.175
regulation of reproductive processGO:2000241540.162
establishment of localization in cellGO:00516494020.160
Mouse
exocrine system developmentGO:00352721620.157
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.156
Mouse
erbb signaling pathwayGO:0038127580.155
Mouse
single organism intracellular transportGO:19025822070.154
Mouse
cellular component assembly involved in morphogenesisGO:00109271510.145
histolysisGO:00075591020.142
cell deathGO:00082192790.141
Human Mouse
autophagic cell deathGO:0048102830.139
covalent chromatin modificationGO:00165691060.135
modification dependent macromolecule catabolic processGO:0043632790.132
Mouse
regulation of phosphorus metabolic processGO:00511742100.127
Human Mouse
germarium derived egg chamber formationGO:00072931010.124
skin developmentGO:0043588650.123
Mouse
respiratory system developmentGO:00605412130.123
Mouse
cellular protein catabolic processGO:0044257830.120
Mouse
oocyte differentiationGO:00099941450.118
deathGO:00162652840.117
Human Mouse
secretionGO:00469031090.116
Mouse
anatomical structure homeostasisGO:0060249970.116
circulatory system developmentGO:0072359820.113
Zebrafish Mouse
striated muscle tissue developmentGO:0014706270.113
organelle assemblyGO:00709251980.112
Mouse
establishment of protein localizationGO:00451841630.111
Mouse
salivary gland histolysisGO:0035070880.110
transcription from rna polymerase ii promoterGO:00063663680.108
Mouse
positive regulation of multicellular organismal processGO:00512401430.106
Mouse
germarium derived female germ line cyst formationGO:0030727420.102
regulation of transportGO:00510491810.100
chromosome organizationGO:00512763600.098
small molecule metabolic processGO:00442813050.098
salivary gland cell autophagic cell deathGO:0035071830.097
heart developmentGO:0007507820.096
Mouse
positive regulation of macromolecule biosynthetic processGO:00105572830.096
peripheral nervous system developmentGO:0007422520.095
retinal cell programmed cell deathGO:0046666250.095
positive regulation of developmental processGO:00510941430.094
negative regulation of nitrogen compound metabolic processGO:00511722650.091
Mouse
regulation of neuron differentiationGO:00456641030.088
Mouse
positive regulation of apoptotic signaling pathwayGO:200123540.087
Mouse
positive regulation of cellular component organizationGO:00511301560.087
epidermal cell differentiationGO:0009913510.086
homeostatic processGO:00425921990.082
Human Mouse
imaginal disc derived wing vein morphogenesisGO:0008586440.081
establishment of tissue polarityGO:0007164870.080
nuclear divisionGO:00002803320.078
carbohydrate derivative metabolic processGO:19011352170.077
Mouse
positive regulation of epithelial cell differentiationGO:003085810.077
actin filament organizationGO:00070151260.076
blastoderm segmentationGO:00073501590.074
actin cytoskeleton organizationGO:00300362060.073
cellular macromolecular complex assemblyGO:00346221530.071
regulation of cell deathGO:00109411730.070
Human Mouse
sensory perceptionGO:00076001960.069
muscle tissue developmentGO:0060537300.067
regulation of transcription from rna polymerase ii promoterGO:00063573780.067
Mouse
retina development in camera type eyeGO:006004140.065
positive regulation of signalingGO:00230562430.064
Mouse Worm
modification dependent protein catabolic processGO:0019941780.064
Mouse
cellular amino acid metabolic processGO:0006520610.062
membrane organizationGO:00610241120.062
ubiquitin dependent protein catabolic processGO:0006511780.060
Mouse
negative regulation of multicellular organismal processGO:00512411420.058
Mouse
purine nucleotide metabolic processGO:00061631460.057
cellular macromolecule catabolic processGO:00442651360.057
Mouse
response to radiationGO:00093141550.057
spindle organizationGO:00070512530.056
proteolysisGO:00065081920.056
Human Mouse
nucleoside phosphate metabolic processGO:00067531620.056
positive regulation of transportGO:0051050920.055
stress activated mapk cascadeGO:0051403520.055
multicellular organismal reproductive behaviorGO:00330571100.055
Worm
endocytosisGO:00068973100.054
hair cell differentiationGO:0035315470.053
cell cycle phase transitionGO:00447701400.053
mitotic cell cycle phase transitionGO:00447721380.052
negative regulation of cell developmentGO:0010721620.052
Mouse
regulation of multicellular organismal developmentGO:20000264140.051
Mouse
imaginal disc derived wing vein specificationGO:0007474480.051
positive regulation of notch signaling pathwayGO:0045747340.051
Worm
embryonic pattern specificationGO:00098801740.050
protein complex assemblyGO:00064612000.050
Mouse
negative regulation of transcription dna templatedGO:00458922370.049
Mouse
imaginal disc derived wing morphogenesisGO:00074763370.049
epidermis developmentGO:0008544650.049
Mouse
spermatid developmentGO:0007286980.048
developmental programmed cell deathGO:00106231380.047
muscle structure developmentGO:00610612240.047
regulation of protein metabolic processGO:00512462560.047
Mouse
mitotic cytokinesisGO:0000281500.047
negative regulation of nucleobase containing compound metabolic processGO:00459342610.047
Mouse
gland developmentGO:00487321910.047
Mouse
organophosphate metabolic processGO:00196371950.045
central nervous system developmentGO:00074172010.045
Zebrafish Mouse
secretion by cellGO:00329401010.045
Mouse
positive regulation of endocytosisGO:0045807220.045
regulation of proteolysis involved in cellular protein catabolic processGO:1903050440.045
Mouse
eye photoreceptor cell differentiationGO:00017541450.045
muscle organ developmentGO:00075171270.044
regulation of establishment of protein localizationGO:0070201610.044
morphogenesis of an epitheliumGO:00020092760.044
Mouse
dendrite morphogenesisGO:00488131990.044
tube morphogenesisGO:00352391910.044
Mouse
germ line cyst formationGO:0048134440.044
positive regulation of cell deathGO:0010942690.044
Mouse
wing disc morphogenesisGO:00074723440.044
cellular response to endogenous stimulusGO:0071495800.043
Worm
chaeta developmentGO:0022416970.042
chorion containing eggshell formationGO:00073041050.042
defense response to other organismGO:00985422250.042
cardiovascular system developmentGO:0072358820.042
Zebrafish Mouse
positive regulation of cellular biosynthetic processGO:00313283160.041
protein transportGO:00150311550.041
Mouse
growthGO:00400073590.040
reproductive behaviorGO:00190981220.038
Worm
retina morphogenesis in camera type eyeGO:006004220.038
regulation of protein transportGO:0051223570.037
positive regulation of cell differentiationGO:0045597640.037
larval developmentGO:00021641040.036
regulation of cell proliferationGO:00421271630.036
instar larval developmentGO:0002168550.036
chromatin organizationGO:00063252070.035
phagocytosisGO:00069092150.035
formation of anatomical boundaryGO:0048859370.035
muscle cell developmentGO:0055001500.034
establishment of planar polarityGO:0001736870.034
negative regulation of signal transductionGO:00099682060.033
Mouse
cytokinesisGO:0000910900.033
regulation of neurogenesisGO:00507671580.033
Mouse
guanosine containing compound metabolic processGO:1901068740.032
cellular response to growth factor stimulusGO:0071363300.032
Worm
regulation of locomotionGO:0040012420.032
cellular protein modification processGO:00064644380.032
Mouse
regulation of transposition rna mediatedGO:001052530.032
molting cycleGO:0042303560.032
Mouse
regulation of catabolic processGO:00098941700.031
Mouse
protein localization to organelleGO:0033365820.031
regulation of cell developmentGO:00602842150.031
Mouse
smoothened signaling pathway involved in ventral spinal cord patterningGO:002191000.031
histone acetylationGO:0016573380.031
positive regulation of protein transportGO:0051222370.030
wound healingGO:0042060750.030
positive regulation of protein localization to nucleusGO:1900182210.030
negative regulation of nervous system developmentGO:0051961920.030
Mouse
regulation of apoptotic processGO:00429811300.030
Human Mouse
positive regulation of nucleobase containing compound metabolic processGO:00459353320.029
regulation of phosphate metabolic processGO:00192202100.029
Human Mouse
dendrite developmentGO:00163582040.029
cellular catabolic processGO:00442483720.028
Mouse
transposition rna mediatedGO:003219730.028
regulation of nervous system developmentGO:00519602480.028
Mouse
glial cell fate determinationGO:000740330.028
positive regulation of fibroblast growth factor receptor signaling pathwayGO:004574350.028
chitin based cuticle developmentGO:0040003490.028
regulation of protein catabolic processGO:0042176550.028
Mouse
spindle localizationGO:0051653220.028
eggshell chorion assemblyGO:0007306660.027
determination of dorsal ventral asymmetryGO:004826230.027
syncytium formation by plasma membrane fusionGO:0000768430.027
regulation of hemocyte proliferationGO:0035206370.026
nucleus localizationGO:0051647340.026
proteoglycan metabolic processGO:0006029100.026
response to abiotic stimulusGO:00096283410.026
Worm
single organism cellular localizationGO:19025801800.026
amine metabolic processGO:0009308120.026
regulation of mitotic cell cycleGO:00073461900.025
negative regulation of neurogenesisGO:0050768530.025
Mouse
spermatogenesisGO:00072832000.025
regulation of epithelial cell proliferationGO:005067840.025
regulation of phosphorylationGO:00423251470.025
Human Mouse
protein acylationGO:0043543420.025
positive regulation of phosphorus metabolic processGO:00105621390.025
Mouse
transition metal ion homeostasisGO:0055076170.025
nucleoside triphosphate metabolic processGO:00091411200.025
stress activated protein kinase signaling cascadeGO:0031098550.024
morphogenesis of an epithelial budGO:006057230.024
leg disc morphogenesisGO:0007478800.024
regulation of cell morphogenesisGO:00226041630.024
Mouse
intracellular signal transductionGO:00355563000.024
Mouse
localization of cellGO:00516742570.024
Mouse
regulation of cellular protein catabolic processGO:1903362440.024
Mouse
muscle tissue morphogenesisGO:006041520.024
smoothened signaling pathwayGO:0007224490.023
digestive tract morphogenesisGO:00485461270.023
cell cycle arrestGO:000705040.023
imaginal disc derived leg morphogenesisGO:0007480800.023
regulation of cell shapeGO:00083601130.022
oocyte constructionGO:00073081120.022
rna localizationGO:00064031150.022
neuron fate commitmentGO:0048663500.022
regulation of dna templated transcription elongationGO:0032784170.022
macroautophagyGO:0016236420.021
Mouse
regulation of protein stabilityGO:0031647430.021
developmental growthGO:00485892800.021
endomembrane system organizationGO:00102561190.021
purine containing compound metabolic processGO:00725211550.021
positive regulation of protein modification processGO:0031401580.021
Mouse
establishment of mitotic spindle localizationGO:0040001170.020
response to transition metal nanoparticleGO:199026790.020
female meiotic divisionGO:0007143700.020
proteolysis involved in cellular protein catabolic processGO:0051603830.020
Mouse
response to endogenous stimulusGO:00097191190.020
Worm
negative regulation of response to stimulusGO:00485852580.020
Mouse
nucleotide metabolic processGO:00091171610.020
sperm individualizationGO:0007291480.020
regulation of chromosome segregationGO:0051983320.020
protein import into nucleusGO:0006606510.019
establishment of cell polarityGO:0030010400.019
nucleobase containing small molecule metabolic processGO:00550861740.019
maintenance of protein locationGO:0045185280.019
regulation of organ morphogenesisGO:2000027780.019
cytoskeleton dependent cytokinesisGO:0061640810.019
wnt signaling pathwayGO:0016055980.019
Zebrafish
apoptotic process involved in morphogenesisGO:006056130.019
positive regulation of gene expressionGO:00106282900.018
purine ribonucleoside triphosphate metabolic processGO:00092051190.018
ribonucleoside triphosphate metabolic processGO:00091991190.018
oocyte axis specificationGO:00073091080.018
intracellular transportGO:00469072280.018
Mouse
organophosphate catabolic processGO:00464341120.018
oocyte developmentGO:00485991240.018
regulation of cellular response to stressGO:0080135890.017
response to biotic stimulusGO:00096072940.017
actomyosin structure organizationGO:0031032560.017
mrna processingGO:00063971040.017
regulation of mapk cascadeGO:0043408920.017
Mouse
sulfur compound metabolic processGO:0006790590.017
canonical wnt signaling pathwayGO:0060070210.017
Zebrafish
regulation of jnk cascadeGO:0046328400.017
single organism membrane organizationGO:0044802930.017
compound eye photoreceptor cell differentiationGO:00017511400.017
cell recognitionGO:00080371020.017
single organism nuclear importGO:1902593510.016
nephron developmentGO:007200630.016
regulation of nucleotide metabolic processGO:0006140620.016
pigmentationGO:0043473750.016
Zebrafish
ribonucleoside catabolic processGO:00424541120.016
negative regulation of cellular component organizationGO:00511291080.016
Mouse
positive regulation of neuron differentiationGO:0045666260.016
positive regulation of neurogenesisGO:0050769410.016
single organism biosynthetic processGO:00447112060.016
oxoacid metabolic processGO:00434361030.016
establishment or maintenance of apical basal cell polarityGO:0035088340.016
histone modificationGO:00165701060.016
exocytosisGO:0006887280.015
Mouse
transforming growth factor beta receptor signaling pathwayGO:0007179160.015
Worm
positive regulation of rna metabolic processGO:00512542710.015
muscle system processGO:0003012210.015
Mouse
negative regulation of molecular functionGO:0044092510.015
Mouse
response to woundingGO:0009611940.015
regulation of mitosisGO:0007088560.015
formation of organ boundaryGO:0010160300.015
regulation of compound eye retinal cell programmed cell deathGO:0046669180.015
embryo development ending in birth or egg hatchingGO:00097921520.015
Mouse
regulation of developmental growthGO:00486381740.015
purine ribonucleotide catabolic processGO:00091541090.015
protein phosphorylationGO:00064681690.014
Mouse
i kappab kinase nf kappab signalingGO:000724960.014
regulation of cell differentiationGO:00455953020.014
Mouse
embryonic morphogenesisGO:00485982060.014
Mouse
leg disc developmentGO:0035218920.014
cytoplasmic transportGO:00164821300.014
carbohydrate derivative biosynthetic processGO:1901137850.014
Mouse
axon cargo transportGO:0008088290.014
brain developmentGO:00074201200.014
Zebrafish Mouse
amide biosynthetic processGO:0043604420.014
establishment of spindle localizationGO:0051293220.014
negative regulation of intrinsic apoptotic signaling pathwayGO:200124310.014
negative regulation of cell differentiationGO:00455961430.014
Mouse
negative regulation of organelle organizationGO:0010639560.014
regulation of cellular ketone metabolic processGO:001056530.014
regulation of imaginal disc growthGO:0045570260.014
regulation of epidermal cell differentiationGO:004560430.013
glycoprotein biosynthetic processGO:0009101410.013
Mouse
regulation of cellular amine metabolic processGO:003323830.013
rna processingGO:00063961470.013
regulation of intracellular protein transportGO:0033157460.013
neuron recognitionGO:00080381010.013
positive regulation of cellular amine metabolic processGO:003324000.013
nucleotide catabolic processGO:00091661090.013
rna splicingGO:0008380830.013
negative regulation of epidermal growth factor receptor signaling pathwayGO:0042059290.013
Mouse
macromolecule catabolic processGO:00090571610.013
Mouse
purine containing compound catabolic processGO:00725231120.013
regulation of bmp signaling pathwayGO:0030510230.013
cell proliferationGO:00082832990.013
Mouse
establishment of organelle localizationGO:00516561220.012
Mouse
regulation of intracellular transportGO:0032386640.012
negative regulation of notch signaling pathwayGO:0045746410.012
regulation of protein localizationGO:0032880760.012
cellular component disassemblyGO:0022411460.012
negative regulation of epithelial cell proliferationGO:005068040.012
gtp metabolic processGO:0046039720.012
organelle localizationGO:00516401480.012
Mouse
oenocyte developmentGO:000743880.012
regulation of mitotic cell cycle phase transitionGO:19019901300.012
ribonucleoside metabolic processGO:00091191270.012
meiotic nuclear divisionGO:00071261510.012
regulation of insulin like growth factor receptor signaling pathwayGO:004356730.012
endosome transport via multivesicular body sorting pathwayGO:0032509120.012
positive regulation of rna biosynthetic processGO:19026802660.012
neurological system processGO:00508773580.012
Mouse
positive regulation of execution phase of apoptosisGO:190011940.012
myotube differentiationGO:0014902460.012
defense responseGO:00069523000.012
positive regulation of nucleic acid templated transcriptionGO:19035082660.012
cellular ketone metabolic processGO:0042180240.012
regulation of nucleocytoplasmic transportGO:0046822350.011
positive regulation of nervous system developmentGO:0051962690.011
regulation of pathway restricted smad protein phosphorylationGO:006039310.011
spinal cord dorsal ventral patterningGO:002151310.011
regulation of cellular component movementGO:0051270420.011
male gamete generationGO:00482322010.011
regulation of execution phase of apoptosisGO:190011750.011
establishment of spindle orientationGO:0051294180.011
positive regulation of biosynthetic processGO:00098913160.011
regulation of cytoskeleton organizationGO:0051493890.011
positive regulation of proteasomal protein catabolic processGO:1901800200.011
Mouse
regulation of catalytic activityGO:00507901850.011
Human Mouse
ribonucleotide catabolic processGO:00092611090.011
regulation of response to stressGO:00801342000.011
skeletal muscle tissue developmentGO:0007519130.011
protein localization to nucleusGO:0034504550.011
hemocyte developmentGO:000751670.011
glycoprotein metabolic processGO:0009100410.011
Mouse
regulation of localizationGO:00328792750.011
signal transduction by phosphorylationGO:00230141070.011
Mouse
positive regulation of bindingGO:005109940.011
photoreceptor cell differentiationGO:00465301700.010
carbohydrate derivative catabolic processGO:19011361180.010
spinal cord patterningGO:002151110.010
neuron fate determinationGO:004866410.010
disaccharide metabolic processGO:000598440.010
morphogenesis of embryonic epitheliumGO:0016331940.010
cellularizationGO:0007349900.010
positive regulation of nitrogen compound metabolic processGO:00511733540.010
glycosyl compound metabolic processGO:19016571270.010
neuron fate specificationGO:0048665120.010
histone h4 acetylationGO:0043967130.010
cellular homeostasisGO:0019725800.010
Human Mouse
protein complex biogenesisGO:00702712010.010
Mouse
entry into cell of other organism involved in symbiotic interactionGO:005180630.010
intracellular protein transportGO:00068861040.010

Psn disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.111
Human
muscle tissue diseaseDOID:6600.034
Human
muscular diseaseDOID:008000000.034
Human
musculoskeletal system diseaseDOID:1700.034
Human
cardiovascular system diseaseDOID:128700.027
Human
heart diseaseDOID:11400.016
Human
cardiomyopathyDOID:005070000.016
Human
myopathyDOID:42300.016
Human
intrinsic cardiomyopathyDOID:006003600.016
Human