IMP: Integrative Multi-species Prediction

Drosophila melanogaster

64 known processes

Nf-YC (Dmel_CG3075)

Nuclear factor Y-box C

(Aliases: NF-YC,CG3075,nf-yc,Dmel\CG3075)

FLYBASE: FBgn0029905
Entrez: 31622
UniProtKB: Q9W3V9

Process Predictions
Disease Predictions

Nf-YC biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.976
negative regulation of cellular biosynthetic process	GO:0031327	277	0.960
negative regulation of transcription dna templated	GO:0045892	237	0.957
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.926
negative regulation of biosynthetic process	GO:0009890	277	0.903
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.866	Yeast
transcription from rna polymerase ii promoter	GO:0006366	368	0.833	Yeast
negative regulation of rna metabolic process	GO:0051253	251	0.830
negative regulation of rna biosynthetic process	GO:1902679	240	0.767
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.710
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.704	Yeast
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.670
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.638	Yeast
positive regulation of transcription dna templated	GO:0045893	266	0.623	Yeast
negative regulation of gene expression	GO:0010629	387	0.599
positive regulation of rna metabolic process	GO:0051254	271	0.572	Yeast
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.558
positive regulation of cellular biosynthetic process	GO:0031328	316	0.552	Yeast
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.502	Yeast
regulation of gene silencing	GO:0060968	63	0.442
positive regulation of gene expression	GO:0010628	290	0.421	Yeast
negative regulation of cellular metabolic process	GO:0031324	382	0.421
positive regulation of macromolecule metabolic process	GO:0010604	405	0.395	Yeast
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.387
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.386	Yeast
nuclear division	GO:0000280	332	0.369
salivary gland development	GO:0007431	162	0.348
chromosome organization	GO:0051276	360	0.329
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.317	Yeast
salivary gland morphogenesis	GO:0007435	145	0.314
gland development	GO:0048732	191	0.283
gene silencing	GO:0016458	138	0.280
sister chromatid segregation	GO:0000819	92	0.262
cell proliferation	GO:0008283	299	0.224
response to external biotic stimulus	GO:0043207	293	0.215
homeostatic process	GO:0042592	199	0.195
death	GO:0016265	284	0.189
circulatory system development	GO:0072359	82	0.186
cell death	GO:0008219	279	0.185
negative regulation of gene expression epigenetic	GO:0045814	77	0.182
imaginal disc derived appendage development	GO:0048737	399	0.178
taxis	GO:0042330	304	0.169
gland morphogenesis	GO:0022612	145	0.168
response to abiotic stimulus	GO:0009628	341	0.162
cell migration	GO:0016477	238	0.159
exocrine system development	GO:0035272	162	0.155
response to alcohol	GO:0097305	95	0.150
response to biotic stimulus	GO:0009607	294	0.141
epithelium migration	GO:0090132	148	0.130
programmed cell death	GO:0012501	257	0.126
small molecule metabolic process	GO:0044281	305	0.125
positive regulation of biosynthetic process	GO:0009891	316	0.125	Yeast
cellular protein modification process	GO:0006464	438	0.120
histolysis	GO:0007559	102	0.116
tissue migration	GO:0090130	155	0.113
oxoacid metabolic process	GO:0043436	103	0.113
ameboidal type cell migration	GO:0001667	151	0.112
positive regulation of cellular component biogenesis	GO:0044089	80	0.109
mitotic cell cycle phase transition	GO:0044772	138	0.107
regulation of chromatin silencing	GO:0031935	36	0.107
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.106
mitotic sister chromatid segregation	GO:0000070	87	0.106
organelle fission	GO:0048285	340	0.106
chromatin modification	GO:0016568	147	0.103
positive regulation of rna biosynthetic process	GO:1902680	266	0.096	Yeast
muscle structure development	GO:0061061	224	0.093
regulation of cell proliferation	GO:0042127	163	0.085
salivary gland cell autophagic cell death	GO:0035071	83	0.084
regulation of cellular amino acid metabolic process	GO:0006521	0	0.080
stem cell differentiation	GO:0048863	117	0.079
mitotic nuclear division	GO:0007067	213	0.079
regulation of gene expression epigenetic	GO:0040029	128	0.074
carboxylic acid metabolic process	GO:0019752	92	0.074
chromatin silencing	GO:0006342	76	0.074
mitotic cell cycle embryonic	GO:0045448	38	0.069
regulation of cellular protein metabolic process	GO:0032268	243	0.069
positive regulation of cellular component organization	GO:0051130	156	0.069
regulation of molecular function	GO:0065009	217	0.067
developmental programmed cell death	GO:0010623	138	0.067
embryonic morphogenesis	GO:0048598	206	0.065
wing disc morphogenesis	GO:0007472	344	0.063
camera type eye development	GO:0043010	4	0.061	Zebrafish
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.059
cellular amine metabolic process	GO:0044106	12	0.057
regulation of chromosome organization	GO:0033044	64	0.057
protein modification process	GO:0036211	438	0.057
morphogenesis of an epithelium	GO:0002009	276	0.056
organelle localization	GO:0051640	148	0.055
post embryonic appendage morphogenesis	GO:0035120	385	0.053
positive regulation of protein complex assembly	GO:0031334	22	0.050
response to organic substance	GO:0010033	284	0.049
response to lipopolysaccharide	GO:0032496	4	0.049
tissue death	GO:0016271	102	0.048
regulation of localization	GO:0032879	275	0.048
embryonic development via the syncytial blastoderm	GO:0001700	148	0.046
histone modification	GO:0016570	106	0.045
autophagic cell death	GO:0048102	83	0.045
organic acid metabolic process	GO:0006082	103	0.045
regulation of protein metabolic process	GO:0051246	256	0.045
chromosome segregation	GO:0007059	157	0.044
regulation of cellular response to stress	GO:0080135	89	0.044
dna metabolic process	GO:0006259	227	0.043
regulation of cellular ketone metabolic process	GO:0010565	3	0.043
histone h3 k4 methylation	GO:0051568	16	0.042
covalent chromatin modification	GO:0016569	106	0.041
signal transduction by phosphorylation	GO:0023014	107	0.039
regulation of cell cycle	GO:0051726	291	0.039
phosphorylation	GO:0016310	294	0.038
rna localization	GO:0006403	115	0.038
regulation of cell cycle phase transition	GO:1901987	130	0.035
cell motility	GO:0048870	251	0.035
mapk cascade	GO:0000165	107	0.035
regulation of cellular amine metabolic process	GO:0033238	3	0.035
peptidyl lysine modification	GO:0018205	57	0.032
response to other organism	GO:0051707	293	0.031
protein secretion	GO:0009306	45	0.031
cell adhesion	GO:0007155	136	0.030
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.030
mitotic spindle organization	GO:0007052	220	0.030
regulation of multicellular organismal development	GO:2000026	414	0.030
protein alkylation	GO:0008213	43	0.030
positive regulation of signal transduction	GO:0009967	223	0.029
developmental growth	GO:0048589	280	0.029
response to light stimulus	GO:0009416	124	0.029
striated muscle cell differentiation	GO:0051146	90	0.029
positive regulation of cellular protein metabolic process	GO:0032270	118	0.028
localization of cell	GO:0051674	257	0.028
salivary gland histolysis	GO:0035070	88	0.027
eye development	GO:0001654	323	0.027	Zebrafish
intracellular signal transduction	GO:0035556	300	0.025
regulation of cell death	GO:0010941	173	0.025
camera type eye morphogenesis	GO:0048593	2	0.025
establishment of localization in cell	GO:0051649	402	0.024
histone lysine methylation	GO:0034968	32	0.024
regulation of cell shape	GO:0008360	113	0.023
negative regulation of cell proliferation	GO:0008285	69	0.023
regulation of organelle organization	GO:0033043	196	0.023
positive regulation of signaling	GO:0023056	243	0.023
peptidyl amino acid modification	GO:0018193	105	0.023
establishment or maintenance of cell polarity	GO:0007163	167	0.023
positive regulation of response to stimulus	GO:0048584	323	0.022
chromatin organization	GO:0006325	207	0.022
chromosome localization	GO:0050000	20	0.022
regulation of programmed cell death	GO:0043067	152	0.022
stem cell division	GO:0017145	69	0.021
regulation of cell differentiation	GO:0045595	302	0.021
positive regulation of molecular function	GO:0044093	136	0.021
regulation of dna metabolic process	GO:0051052	34	0.021
epithelial cell migration	GO:0010631	148	0.021
tissue morphogenesis	GO:0048729	297	0.021
negative regulation of response to stimulus	GO:0048585	258	0.021
cellular response to chemical stimulus	GO:0070887	199	0.021	Yeast
actin cytoskeleton organization	GO:0030036	206	0.020
response to bacterium	GO:0009617	198	0.020
response to lipid	GO:0033993	38	0.020
muscle cell development	GO:0055001	50	0.019
regulation of response to stress	GO:0080134	200	0.019
cellular amino acid metabolic process	GO:0006520	61	0.019
regulation of catalytic activity	GO:0050790	185	0.019
eye morphogenesis	GO:0048592	260	0.018
regulation of anatomical structure morphogenesis	GO:0022603	242	0.018
cell division	GO:0051301	248	0.018
negative regulation of cell cycle process	GO:0010948	109	0.018
cellular ketone metabolic process	GO:0042180	24	0.018
central nervous system development	GO:0007417	201	0.017
muscle cell differentiation	GO:0042692	103	0.017
regulation of heart contraction	GO:0008016	21	0.017
appendage morphogenesis	GO:0035107	397	0.017
regulation of blood circulation	GO:1903522	21	0.017
positive regulation of mitotic cell cycle	GO:0045931	34	0.017
endomembrane system organization	GO:0010256	119	0.017
dorsal ventral axis specification	GO:0009950	66	0.016
negative regulation of cell communication	GO:0010648	223	0.016
muscle organ development	GO:0007517	127	0.016
defense response to other organism	GO:0098542	225	0.016
regulation of notch signaling pathway	GO:0008593	100	0.016
immune system process	GO:0002376	347	0.016
retina development in camera type eye	GO:0060041	4	0.016	Zebrafish
regulation of phosphorylation	GO:0042325	147	0.016
apoptotic process	GO:0006915	159	0.016
regulation of mitotic cell cycle	GO:0007346	190	0.016
positive regulation of organelle organization	GO:0010638	65	0.016
positive regulation of multicellular organismal process	GO:0051240	143	0.016
protein acylation	GO:0043543	42	0.016
positive regulation of cellular amine metabolic process	GO:0033240	0	0.016
cellular macromolecular complex assembly	GO:0034622	153	0.015
positive regulation of cell communication	GO:0010647	250	0.015
regulation of phosphorus metabolic process	GO:0051174	210	0.015
heart contraction	GO:0060047	26	0.015
hematopoietic progenitor cell differentiation	GO:0002244	1	0.015
cell cycle phase transition	GO:0044770	140	0.014
tube morphogenesis	GO:0035239	191	0.014
regulation of chromatin modification	GO:1903308	28	0.014
regulation of cell cycle process	GO:0010564	181	0.014
sensory organ morphogenesis	GO:0090596	260	0.014
imaginal disc derived leg morphogenesis	GO:0007480	80	0.014
regulation of cell division	GO:0051302	72	0.014
tube development	GO:0035295	244	0.014
organonitrogen compound metabolic process	GO:1901564	318	0.013
cell fate determination	GO:0001709	91	0.013
organic substance transport	GO:0071702	257	0.013
imaginal disc derived wing morphogenesis	GO:0007476	337	0.013
morphogenesis of a polarized epithelium	GO:0001738	93	0.013
positive regulation of gene expression epigenetic	GO:0045815	16	0.013
stem cell proliferation	GO:0072089	88	0.013
respiratory system development	GO:0060541	213	0.013
positive regulation of protein modification process	GO:0031401	58	0.012
establishment of chromosome localization	GO:0051303	20	0.012
regulation of nuclear division	GO:0051783	58	0.012
proteolysis	GO:0006508	192	0.012
negative regulation of signal transduction	GO:0009968	206	0.012
establishment of planar polarity	GO:0001736	87	0.012
response to organic cyclic compound	GO:0014070	89	0.012
protein complex assembly	GO:0006461	200	0.012
cellular response to lipopolysaccharide	GO:0071222	3	0.012
cell cycle comprising mitosis without cytokinesis	GO:0033301	25	0.012
cellular response to biotic stimulus	GO:0071216	4	0.012
growth	GO:0040007	359	0.012
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.012
regulation of protein modification process	GO:0031399	112	0.011
regulation of embryonic development	GO:0045995	68	0.011
circulatory system process	GO:0003013	37	0.011
cell maturation	GO:0048469	144	0.011
actin filament based process	GO:0030029	220	0.011
positive regulation of cell proliferation	GO:0008284	47	0.011
positive regulation of catalytic activity	GO:0043085	118	0.011
negative regulation of cellular component organization	GO:0051129	108	0.011
metaphase plate congression	GO:0051310	19	0.011
methylation	GO:0032259	47	0.011
cell cycle checkpoint	GO:0000075	95	0.011
connective tissue development	GO:0061448	3	0.011
phagocytosis	GO:0006909	215	0.011
regionalization	GO:0003002	416	0.010
stem cell development	GO:0048864	79	0.010
regulation of dna replication	GO:0006275	13	0.010
leg disc morphogenesis	GO:0007478	80	0.010
ubiquitin dependent protein catabolic process	GO:0006511	78	0.010
biological adhesion	GO:0022610	138	0.010
cellular response to molecule of bacterial origin	GO:0071219	3	0.010
regulation of phosphate metabolic process	GO:0019220	210	0.010

Nf-YC disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.027
disease of cellular proliferation	DOID:14566	0.022
cancer	DOID:162	0.022

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