IMP: Integrative Multi-species Prediction

Drosophila melanogaster

303 known processes

gig (Dmel_CG6975)

gigas

(Aliases: dTSC2,6975,dTsc2,Tsc2,Tsc2/gig,CG6975,ME 109,Dmel\CG6975,C1,l(3)109,TSC2,tsc2)

FLYBASE: FBgn0005198
Entrez: 40201
UniProtKB: M9PD17
UniProtKB: Q9VW83

Process Predictions
Disease Predictions

gig biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
cellular response to starvation	GO:0009267	61	0.982
stem cell maintenance	GO:0019827	67	0.981
regulation of cell differentiation	GO:0045595	302	0.965
regulation of developmental growth	GO:0048638	174	0.965
autophagy	GO:0006914	108	0.961
establishment of localization in cell	GO:0051649	402	0.958	Mouse
regulation of cellular component biogenesis	GO:0044087	201	0.935
learning or memory	GO:0007611	141	0.934
response to starvation	GO:0042594	97	0.934
negative regulation of response to stimulus	GO:0048585	258	0.922
regulation of growth	GO:0040008	233	0.916
cellular protein modification process	GO:0006464	438	0.906
negative regulation of nervous system development	GO:0051961	92	0.897
growth	GO:0040007	359	0.893
cellular response to extracellular stimulus	GO:0031668	64	0.885
regulation of autophagy	GO:0010506	62	0.878
negative regulation of signaling	GO:0023057	219	0.878
regulation of multicellular organismal development	GO:2000026	414	0.876
negative regulation of cellular component organization	GO:0051129	108	0.864
regulation of cellular catabolic process	GO:0031329	157	0.863
cellular catabolic process	GO:0044248	372	0.856
regulation of apoptotic process	GO:0042981	130	0.850
autophagic vacuole assembly	GO:0000045	2	0.836
axonogenesis	GO:0007409	290	0.826
catabolic process	GO:0009056	409	0.822
regulation of nervous system development	GO:0051960	248	0.819
compound eye photoreceptor development	GO:0042051	78	0.809
negative regulation of signal transduction	GO:0009968	206	0.808
single organism behavior	GO:0044708	391	0.808
protein localization	GO:0008104	284	0.806	Mouse Rat
negative regulation of developmental growth	GO:0048640	64	0.770
multi organism behavior	GO:0051705	175	0.767
apoptotic process	GO:0006915	159	0.764
response to extracellular stimulus	GO:0009991	116	0.763
oocyte development	GO:0048599	124	0.755
negative regulation of cell communication	GO:0010648	223	0.751
regulation of programmed cell death	GO:0043067	152	0.749
cell death	GO:0008219	279	0.741
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.725	Mouse
macromolecular complex assembly	GO:0065003	256	0.721	Rat
protein modification process	GO:0036211	438	0.713
oocyte differentiation	GO:0009994	145	0.712
regulation of multicellular organism growth	GO:0040014	40	0.694
cellular response to nutrient levels	GO:0031669	62	0.687
regulation of catabolic process	GO:0009894	170	0.687
axon development	GO:0061564	297	0.686
cell division	GO:0051301	248	0.685
heart development	GO:0007507	82	0.683	Mouse
meiotic nuclear division	GO:0007126	151	0.676
larval midgut histolysis	GO:0035069	22	0.674
negative regulation of developmental process	GO:0051093	201	0.665
regulation of cell development	GO:0060284	215	0.656
cell cycle phase transition	GO:0044770	140	0.650
regulation of multi organism process	GO:0043900	131	0.645
single organism cellular localization	GO:1902580	180	0.643	Mouse
response to oxygen containing compound	GO:1901700	200	0.633
nuclear division	GO:0000280	332	0.629
positive regulation of multicellular organism growth	GO:0040018	21	0.624
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.622
dna metabolic process	GO:0006259	227	0.608
positive regulation of macromolecule metabolic process	GO:0010604	405	0.606
eye development	GO:0001654	323	0.600
regulation of cell death	GO:0010941	173	0.599
protein transport	GO:0015031	155	0.598	Mouse
vesicle localization	GO:0051648	55	0.594
multicellular organism growth	GO:0035264	46	0.588
response to organonitrogen compound	GO:0010243	75	0.565
cell proliferation	GO:0008283	299	0.551
eye photoreceptor cell development	GO:0042462	81	0.549
wnt signaling pathway	GO:0016055	98	0.547	Rat
protein complex biogenesis	GO:0070271	201	0.546	Rat
positive regulation of developmental process	GO:0051094	143	0.542
positive regulation of protein metabolic process	GO:0051247	128	0.533
meiotic cell cycle	GO:0051321	171	0.529
developmental growth	GO:0048589	280	0.517
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.511
epithelial cell development	GO:0002064	274	0.507
single organism catabolic process	GO:0044712	228	0.507
ovarian follicle cell development	GO:0030707	248	0.502
determination of adult lifespan	GO:0008340	137	0.501
negative regulation of cell differentiation	GO:0045596	143	0.500
synapse organization	GO:0050808	196	0.482
phosphorylation	GO:0016310	294	0.474
macroautophagy	GO:0016236	42	0.461
germarium derived egg chamber formation	GO:0007293	101	0.454
single organism intracellular transport	GO:1902582	207	0.454	Mouse
cellular protein localization	GO:0034613	160	0.441	Mouse
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.437
eye morphogenesis	GO:0048592	260	0.433
axon guidance	GO:0007411	233	0.431
regulation of cellular component size	GO:0032535	98	0.428
regulation of protein complex assembly	GO:0043254	42	0.423
protein modification by small protein conjugation or removal	GO:0070647	106	0.421
organelle fission	GO:0048285	340	0.417
intracellular transport	GO:0046907	228	0.402	Mouse
compound eye development	GO:0048749	307	0.401
programmed cell death	GO:0012501	257	0.393
regulation of response to stress	GO:0080134	200	0.388
actin filament polymerization	GO:0030041	27	0.385
regulation of cell size	GO:0008361	63	0.380
rna localization	GO:0006403	115	0.380
regionalization	GO:0003002	416	0.379
establishment of organelle localization	GO:0051656	122	0.377
regulation of glial cell proliferation	GO:0060251	11	0.377
positive regulation of cell death	GO:0010942	69	0.365
blastoderm segmentation	GO:0007350	159	0.364
proteolysis	GO:0006508	192	0.362
cellular response to chemical stimulus	GO:0070887	199	0.361
stem cell differentiation	GO:0048863	117	0.358
intracellular signal transduction	GO:0035556	300	0.354
negative regulation of cellular metabolic process	GO:0031324	382	0.353	Mouse Rat
lateral inhibition	GO:0046331	206	0.351
cellular macromolecular complex assembly	GO:0034622	153	0.349
g1 s transition of mitotic cell cycle	GO:0000082	31	0.349
learning	GO:0007612	75	0.331
regulation of organ growth	GO:0046620	42	0.328
negative regulation of neurogenesis	GO:0050768	53	0.324
eye photoreceptor cell differentiation	GO:0001754	145	0.314
neuron projection guidance	GO:0097485	241	0.313
negative regulation of multicellular organismal process	GO:0051241	142	0.312
regulation of anatomical structure size	GO:0090066	163	0.310
brain development	GO:0007420	120	0.309
death	GO:0016265	284	0.309
columnar cuboidal epithelial cell development	GO:0002066	249	0.307
taxis	GO:0042330	304	0.305	Mouse
protein localization to plasma membrane	GO:0072659	13	0.301	Mouse
digestive system development	GO:0055123	149	0.298
positive regulation of cellular component organization	GO:0051130	156	0.294
organic substance catabolic process	GO:1901575	308	0.291
nucleoside triphosphate catabolic process	GO:0009143	108	0.286
actin cytoskeleton organization	GO:0030036	206	0.285
actin filament based process	GO:0030029	220	0.285
protein modification by small protein conjugation	GO:0032446	79	0.281
germarium derived female germ line cyst formation	GO:0030727	42	0.280
protein ubiquitination	GO:0016567	70	0.279
positive regulation of cell communication	GO:0010647	250	0.279
positive regulation of phosphate metabolic process	GO:0045937	139	0.278
protein catabolic process	GO:0030163	101	0.276
compound eye morphogenesis	GO:0001745	249	0.275
chemotaxis	GO:0006935	249	0.275	Mouse
regulation of anatomical structure morphogenesis	GO:0022603	242	0.274
mitotic cell cycle phase transition	GO:0044772	138	0.273
embryonic pattern specification	GO:0009880	174	0.270
positive regulation of signaling	GO:0023056	243	0.268
nucleotide catabolic process	GO:0009166	109	0.267
female germ line cyst formation	GO:0048135	42	0.267
hindbrain development	GO:0030902	2	0.264
response to nitrogen compound	GO:1901698	90	0.262
digestive tract development	GO:0048565	149	0.259
positive regulation of multicellular organismal process	GO:0051240	143	0.258
macromolecule catabolic process	GO:0009057	161	0.257
establishment of vesicle localization	GO:0051650	51	0.248
regulation of cell proliferation	GO:0042127	163	0.243
negative regulation of programmed cell death	GO:0043069	72	0.240
positive regulation of signal transduction	GO:0009967	223	0.240
aging	GO:0007568	143	0.238
regulation of neuron differentiation	GO:0045664	103	0.237
stem cell development	GO:0048864	79	0.235
regulation of cellular response to insulin stimulus	GO:1900076	17	0.231
regulation of response to external stimulus	GO:0032101	115	0.228
purine nucleoside metabolic process	GO:0042278	127	0.226
mapk cascade	GO:0000165	107	0.225	Rat
regulation of neurogenesis	GO:0050767	158	0.224
regulation of phosphorus metabolic process	GO:0051174	210	0.223
locomotory behavior	GO:0007626	176	0.221
positive regulation of cellular biosynthetic process	GO:0031328	316	0.217	Mouse
meiotic cell cycle process	GO:1903046	132	0.217
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.217
regulation of phosphorylation	GO:0042325	147	0.216
germarium derived oocyte fate determination	GO:0007294	26	0.216
regulation of actin filament polymerization	GO:0030833	25	0.215
regulation of cell cycle phase transition	GO:1901987	130	0.207
regulation of cellular protein metabolic process	GO:0032268	243	0.207
reproductive behavior	GO:0019098	122	0.200
regulation of cell cycle	GO:0051726	291	0.197
actin polymerization or depolymerization	GO:0008154	31	0.195
stem cell division	GO:0017145	69	0.195
response to oxidative stress	GO:0006979	86	0.195
regulation of phosphate metabolic process	GO:0019220	210	0.194
neuromuscular junction development	GO:0007528	149	0.192
cellular response to endogenous stimulus	GO:0071495	80	0.189
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.188
transcription from rna polymerase ii promoter	GO:0006366	368	0.188	Mouse
cognition	GO:0050890	141	0.186
tube morphogenesis	GO:0035239	191	0.186	Mouse
oocyte microtubule cytoskeleton organization	GO:0016325	35	0.185
regulation of synapse organization	GO:0050807	110	0.183
rna transport	GO:0050658	46	0.182
epithelial cell migration	GO:0010631	148	0.181
regulation of imaginal disc growth	GO:0045570	26	0.180
positive regulation of programmed cell death	GO:0043068	62	0.180
positive regulation of cellular component biogenesis	GO:0044089	80	0.177
regulation of dendrite morphogenesis	GO:0048814	28	0.174
cell cycle g1 s phase transition	GO:0044843	31	0.174
ribonucleoside metabolic process	GO:0009119	127	0.169
regulation of protein transport	GO:0051223	57	0.165
regulation of organelle organization	GO:0033043	196	0.162
protein complex assembly	GO:0006461	200	0.161	Rat
cardiovascular system development	GO:0072358	82	0.159	Mouse
protein phosphorylation	GO:0006468	169	0.158
guanosine containing compound catabolic process	GO:1901069	74	0.155
regulation of actin filament length	GO:0030832	27	0.154
peptidyl threonine phosphorylation	GO:0018107	2	0.154
organic substance transport	GO:0071702	257	0.154	Mouse
tube development	GO:0035295	244	0.151	Mouse
cellular response to peptide	GO:1901653	28	0.149
larval development	GO:0002164	104	0.149
regulation of cell cycle process	GO:0010564	181	0.148
neuron death	GO:0070997	27	0.147
positive regulation of growth	GO:0045927	75	0.144
forebrain development	GO:0030900	2	0.143
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.142	Mouse
cell motility	GO:0048870	251	0.142
negative regulation of cell cycle	GO:0045786	116	0.142
regulation of intracellular signal transduction	GO:1902531	236	0.140
positive regulation of apoptotic process	GO:0043065	47	0.140
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.140
purine ribonucleoside metabolic process	GO:0046128	127	0.138
cellular response to external stimulus	GO:0071496	66	0.134
positive regulation of molecular function	GO:0044093	136	0.133
positive regulation of nucleoside metabolic process	GO:0045979	47	0.133
cellular protein complex assembly	GO:0043623	71	0.132
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.132
small gtpase mediated signal transduction	GO:0007264	88	0.130
regulation of intracellular transport	GO:0032386	64	0.128
regulation of cellular localization	GO:0060341	136	0.125
positive regulation of biosynthetic process	GO:0009891	316	0.124	Mouse
establishment of protein localization	GO:0045184	163	0.122	Mouse Rat
regulation of synapse structure and activity	GO:0050803	128	0.122
regulation of transport	GO:0051049	181	0.122	Mouse
cellular macromolecule localization	GO:0070727	220	0.121	Mouse
negative regulation of growth	GO:0045926	84	0.120
rho protein signal transduction	GO:0007266	14	0.120
synapse assembly	GO:0007416	143	0.119
oocyte construction	GO:0007308	112	0.119
cytoplasmic transport	GO:0016482	130	0.117	Mouse
amine metabolic process	GO:0009308	12	0.117
cellular response to hormone stimulus	GO:0032870	44	0.116
spindle organization	GO:0007051	253	0.116
cellular response to peptide hormone stimulus	GO:0071375	28	0.115
organonitrogen compound metabolic process	GO:1901564	318	0.114
cellular protein catabolic process	GO:0044257	83	0.114
response to endogenous stimulus	GO:0009719	119	0.113
apoptotic signaling pathway	GO:0097190	27	0.113
negative regulation of apoptotic signaling pathway	GO:2001234	5	0.110
negative regulation of synaptic growth at neuromuscular junction	GO:0045886	39	0.110
organelle assembly	GO:0070925	198	0.109
head development	GO:0060322	135	0.109
sensory organ morphogenesis	GO:0090596	260	0.109
response to hydrogen peroxide	GO:0042542	11	0.108
response to nutrient levels	GO:0031667	114	0.107
multi organism reproductive behavior	GO:0044705	121	0.106
regulation of protein kinase activity	GO:0045859	51	0.105	Mouse Rat
spermatid development	GO:0007286	98	0.104
positive regulation of response to stimulus	GO:0048584	323	0.104
regulation of establishment of protein localization	GO:0070201	61	0.100
carbohydrate derivative catabolic process	GO:1901136	118	0.098
germ line stem cell division	GO:0042078	25	0.096
negative regulation of mitotic cell cycle	GO:0045930	109	0.095
regulation of r7 cell differentiation	GO:0045676	15	0.093
purine ribonucleotide metabolic process	GO:0009150	145	0.092
regulation of mapk cascade	GO:0043408	92	0.092	Rat
immune system process	GO:0002376	347	0.092
single organism nuclear import	GO:1902593	51	0.092	Mouse
cellularization	GO:0007349	90	0.091
endomembrane system organization	GO:0010256	119	0.090	Mouse
regulation of apoptotic signaling pathway	GO:2001233	10	0.089
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.089
embryo development ending in birth or egg hatching	GO:0009792	152	0.088	Mouse
response to organic cyclic compound	GO:0014070	89	0.088
regulation of cellular amine metabolic process	GO:0033238	3	0.087
dendrite development	GO:0016358	204	0.087
eggshell formation	GO:0030703	105	0.086
regulation of localization	GO:0032879	275	0.085	Mouse
regulation of secretion	GO:0051046	44	0.085
positive regulation of wnt signaling pathway	GO:0030177	25	0.085
response to organic substance	GO:0010033	284	0.084
regulation of cytoplasmic transport	GO:1903649	47	0.084
cell growth	GO:0016049	108	0.084
purine containing compound catabolic process	GO:0072523	112	0.083
body morphogenesis	GO:0010171	2	0.083
actin filament organization	GO:0007015	126	0.083
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.083
regulation of mitotic cell cycle	GO:0007346	190	0.082
epithelial cell differentiation	GO:0030855	322	0.082
protein targeting	GO:0006605	64	0.082	Mouse
cellular response to oxygen containing compound	GO:1901701	79	0.081
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.081
heterocycle catabolic process	GO:0046700	166	0.081
negative regulation of insulin receptor signaling pathway	GO:0046627	11	0.079
regulation of wnt signaling pathway	GO:0030111	68	0.079	Rat
positive regulation of phosphorus metabolic process	GO:0010562	139	0.078
regulation of protein localization	GO:0032880	76	0.078
ovarian follicle cell migration	GO:0007297	121	0.078
meiotic spindle organization	GO:0000212	36	0.077
regulation of protein metabolic process	GO:0051246	256	0.077
regulation of neuron projection development	GO:0010975	69	0.076
positive regulation of cellular protein metabolic process	GO:0032270	118	0.075
regulation of organ morphogenesis	GO:2000027	78	0.074
nucleobase containing compound transport	GO:0015931	56	0.073
positive regulation of catabolic process	GO:0009896	105	0.072
peptidyl amino acid modification	GO:0018193	105	0.072
secretion by cell	GO:0032940	101	0.071
dendrite morphogenesis	GO:0048813	199	0.071
negative regulation of cell cycle phase transition	GO:1901988	103	0.071
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.071
localization of cell	GO:0051674	257	0.070
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.070
negative regulation of cell cycle process	GO:0010948	109	0.069
cell type specific apoptotic process	GO:0097285	38	0.069
organ growth	GO:0035265	56	0.068
positive regulation of developmental growth	GO:0048639	62	0.068
cytoplasm organization	GO:0007028	64	0.068
regulation of protein ubiquitination	GO:0031396	22	0.068
regulation of actin polymerization or depolymerization	GO:0008064	27	0.068
insulin receptor signaling pathway	GO:0008286	25	0.067
hemopoiesis	GO:0030097	46	0.067
cellular macromolecule catabolic process	GO:0044265	136	0.066
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.066
regulation of cellular amino acid metabolic process	GO:0006521	0	0.066
positive regulation of transport	GO:0051050	92	0.066
regulation of cellular response to stress	GO:0080135	89	0.065
ribose phosphate metabolic process	GO:0019693	145	0.065
olfactory behavior	GO:0042048	97	0.064
segmentation	GO:0035282	207	0.064
oxoacid metabolic process	GO:0043436	103	0.062
positive regulation of cell development	GO:0010720	61	0.062
negative regulation of cellular protein metabolic process	GO:0032269	85	0.062	Mouse Rat
regulation of gtpase activity	GO:0043087	44	0.061
photoreceptor cell differentiation	GO:0046530	170	0.061
intracellular protein transport	GO:0006886	104	0.061	Mouse
vacuolar transport	GO:0007034	13	0.060
synaptic growth at neuromuscular junction	GO:0051124	119	0.060
negative regulation of cell death	GO:0060548	81	0.060
male gamete generation	GO:0048232	201	0.059
signal transduction by phosphorylation	GO:0023014	107	0.059	Rat
carbohydrate derivative metabolic process	GO:1901135	217	0.059
organelle localization	GO:0051640	148	0.058
regulation of erk1 and erk2 cascade	GO:0070372	39	0.056
purine nucleoside catabolic process	GO:0006152	112	0.056
positive regulation of cell differentiation	GO:0045597	64	0.056
regulation of synapse assembly	GO:0051963	94	0.056
negative regulation of phosphate metabolic process	GO:0045936	45	0.056	Mouse Rat
positive regulation of cellular amine metabolic process	GO:0033240	0	0.056
cellular response to dna damage stimulus	GO:0006974	223	0.055
muscle cell differentiation	GO:0042692	103	0.055
larval midgut cell programmed cell death	GO:0035096	19	0.054
somatic stem cell maintenance	GO:0035019	14	0.054
multicellular organismal reproductive behavior	GO:0033057	110	0.054
negative regulation of autophagy	GO:0010507	16	0.053
negative regulation of apoptotic process	GO:0043066	63	0.053
purine ribonucleoside catabolic process	GO:0046130	112	0.053
positive regulation of protein phosphorylation	GO:0001934	34	0.053
establishment of synaptic vesicle localization	GO:0097480	50	0.053
regulation of cytoskeleton organization	GO:0051493	89	0.052
nitrogen compound transport	GO:0071705	85	0.052
response to acid chemical	GO:0001101	25	0.052
positive regulation of autophagy	GO:0010508	21	0.052
regulation of proteolysis	GO:0030162	87	0.052
germ line stem cell maintenance	GO:0030718	50	0.051
negative regulation of phosphorus metabolic process	GO:0010563	45	0.051	Mouse Rat
membrane organization	GO:0061024	112	0.051	Mouse
negative regulation of organ growth	GO:0046621	15	0.051
positive regulation of gliogenesis	GO:0014015	5	0.051
axis specification	GO:0009798	167	0.050
proteasomal protein catabolic process	GO:0010498	59	0.049
response to insulin	GO:0032868	29	0.047
meiotic chromosome segregation	GO:0045132	59	0.047
regulation of system process	GO:0044057	36	0.047
lipid modification	GO:0030258	24	0.047
negative regulation of cell development	GO:0010721	62	0.047
gtp metabolic process	GO:0046039	72	0.046
establishment of rna localization	GO:0051236	47	0.046
imaginal disc derived wing morphogenesis	GO:0007476	337	0.046
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.046
kidney development	GO:0001822	3	0.046
ribonucleotide metabolic process	GO:0009259	145	0.046
cellular lipid metabolic process	GO:0044255	83	0.045
developmental maturation	GO:0021700	172	0.045
response to peptide hormone	GO:0043434	29	0.045
meiosis i	GO:0007127	59	0.045
ras protein signal transduction	GO:0007265	88	0.045
central nervous system development	GO:0007417	201	0.045
regulation of ras protein signal transduction	GO:0046578	93	0.045
carboxylic acid metabolic process	GO:0019752	92	0.044
multi multicellular organism process	GO:0044706	123	0.044
nuclear import	GO:0051170	51	0.044	Mouse
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.043
multicellular organismal aging	GO:0010259	140	0.043
cellular response to nitrogen compound	GO:1901699	51	0.042
posttranscriptional regulation of gene expression	GO:0010608	145	0.042
secretion	GO:0046903	109	0.042
nucleobase containing small molecule metabolic process	GO:0055086	174	0.041
kidney epithelium development	GO:0072073	3	0.041
regulation of necrotic cell death	GO:0010939	1	0.041
pre mirna processing	GO:0031054	3	0.041
protein localization to organelle	GO:0033365	82	0.040	Mouse
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.040
synaptic vesicle localization	GO:0097479	53	0.040
molting cycle	GO:0042303	56	0.040
nucleoside triphosphate metabolic process	GO:0009141	120	0.039
regulation of cell morphogenesis	GO:0022604	163	0.039
divalent inorganic cation homeostasis	GO:0072507	29	0.039
regulation of gtp catabolic process	GO:0033124	44	0.038
positive regulation of purine nucleotide catabolic process	GO:0033123	46	0.038
photoreceptor cell development	GO:0042461	96	0.038
response to peptide	GO:1901652	29	0.038
negative regulation of notch signaling pathway	GO:0045746	41	0.037
response to alcohol	GO:0097305	95	0.037
regulation of protein modification by small protein conjugation or removal	GO:1903320	25	0.036
modification dependent protein catabolic process	GO:0019941	78	0.036
wing disc morphogenesis	GO:0007472	344	0.036
vesicle organization	GO:0016050	44	0.036
positive regulation of mapk cascade	GO:0043410	63	0.035
regulation of ras gtpase activity	GO:0032318	38	0.035
germ line cyst formation	GO:0048134	44	0.035
telencephalon development	GO:0021537	2	0.034
erk1 and erk2 cascade	GO:0070371	39	0.034
establishment of protein localization to membrane	GO:0090150	11	0.034	Mouse
lipid metabolic process	GO:0006629	121	0.034
g protein coupled receptor signaling pathway	GO:0007186	136	0.034
regulation of actin cytoskeleton organization	GO:0032956	42	0.034
regulation of nucleocytoplasmic transport	GO:0046822	35	0.034
response to lipid	GO:0033993	38	0.034
positive regulation of gtpase activity	GO:0043547	43	0.033
spermatogenesis	GO:0007283	200	0.033
spindle assembly	GO:0051225	80	0.033
regulation of meiosis	GO:0040020	3	0.033
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.033	Mouse
ubiquitin dependent protein catabolic process	GO:0006511	78	0.033
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.033
appendage development	GO:0048736	401	0.033
sex differentiation	GO:0007548	81	0.033
negative regulation of protein phosphorylation	GO:0001933	17	0.032	Mouse Rat
digestive tract morphogenesis	GO:0048546	127	0.032
positive regulation of erk1 and erk2 cascade	GO:0070374	36	0.032
synaptic transmission	GO:0007268	288	0.032
neurological system process	GO:0050877	358	0.032
cell migration	GO:0016477	238	0.032
oocyte fate determination	GO:0030716	27	0.032
endocytosis	GO:0006897	310	0.032
positive regulation of intracellular signal transduction	GO:1902533	116	0.031
peptidyl threonine modification	GO:0018210	3	0.031
synaptic vesicle transport	GO:0048489	50	0.031
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.031
positive regulation of gtp catabolic process	GO:0033126	43	0.031
tor signaling	GO:0031929	32	0.031
positive regulation of establishment of protein localization to plasma membrane	GO:0090004	3	0.031
positive regulation of phosphorylation	GO:0042327	87	0.031
embryonic morphogenesis	GO:0048598	206	0.030	Mouse
plasma membrane organization	GO:0007009	26	0.030	Mouse
regulation of protein polymerization	GO:0032271	28	0.030
negative regulation of cell size	GO:0045792	19	0.030
gastrulation	GO:0007369	70	0.030
phosphatidylinositol mediated signaling	GO:0048015	4	0.030	Mouse
negative regulation of synapse assembly	GO:0051964	39	0.030
oocyte anterior posterior axis specification	GO:0007314	72	0.030
anterior posterior pattern specification	GO:0009952	136	0.030
hematopoietic or lymphoid organ development	GO:0048534	57	0.030
small molecule metabolic process	GO:0044281	305	0.030
regulation of nucleoside metabolic process	GO:0009118	50	0.029
positive regulation of protein modification process	GO:0031401	58	0.029
positive regulation of protein localization to plasma membrane	GO:1903078	3	0.029
positive regulation of cellular catabolic process	GO:0031331	95	0.029
positive regulation of nucleotide catabolic process	GO:0030813	46	0.029
mrna processing	GO:0006397	104	0.028
anterior posterior axis specification embryo	GO:0008595	103	0.028
regulation of photoreceptor cell differentiation	GO:0046532	34	0.028
mitotic g2 m transition checkpoint	GO:0044818	70	0.028
inositol lipid mediated signaling	GO:0048017	4	0.028	Mouse
regulation of membrane potential	GO:0042391	35	0.027
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.027
guanosine containing compound metabolic process	GO:1901068	74	0.027
regulation of meiotic cell cycle	GO:0051445	9	0.027
nucleoside metabolic process	GO:0009116	127	0.026
tissue death	GO:0016271	102	0.026
aromatic compound catabolic process	GO:0019439	166	0.026
cystoblast division	GO:0007282	10	0.026
glycosyl compound catabolic process	GO:1901658	112	0.026
regulation of nurse cell apoptotic process	GO:0045477	9	0.026
oocyte axis specification	GO:0007309	108	0.025
regulation of hydrolase activity	GO:0051336	97	0.025
female meiotic division	GO:0007143	70	0.025
negative regulation of neuroblast proliferation	GO:0007406	27	0.025
response to hexose	GO:0009746	3	0.025
eye pigment granule organization	GO:0008057	12	0.025
regulation of epithelial cell proliferation	GO:0050678	4	0.024	Rat
negative regulation of protein modification process	GO:0031400	29	0.024	Mouse Rat
notch signaling pathway	GO:0007219	120	0.024
olfactory learning	GO:0008355	56	0.024
gliogenesis	GO:0042063	80	0.023
regulation of gliogenesis	GO:0014013	11	0.023
regulation of purine nucleotide catabolic process	GO:0033121	48	0.023

gig disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.119
cancer	DOID:162	0.087
organ system cancer	DOID:0050686	0.087
disease of anatomical entity	DOID:7	0.029
central nervous system disease	DOID:331	0.024
nervous system disease	DOID:863	0.024

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