IMP: Integrative Multi-species Prediction

Drosophila melanogaster

5 known processes

Mlc1 (Dmel_CG5596)

Myosin alkali light chain 1

(Aliases: mlc,Mlci,Dmel\CG5596,LC1,MLC-ALK,ELC,MlcI,mlc1,mlcl,FBgn0002772,mlc-alk,CG5596,Mlc-1,DmMLC1,MLC1)

Entrez: 43323
FLYBASE: FBgn0002772
UniProtKB: P06742

Process Predictions
Disease Predictions

Mlc1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
striated muscle cell differentiation	GO:0051146	90	0.692
muscle cell differentiation	GO:0042692	103	0.505
muscle thin filament assembly	GO:0071689	5	0.242
muscle structure development	GO:0061061	224	0.191
larval development	GO:0002164	104	0.175
aging	GO:0007568	143	0.170
myotube differentiation	GO:0014902	46	0.160
striated muscle cell development	GO:0055002	50	0.144
actin filament organization	GO:0007015	126	0.138
phosphorylation	GO:0016310	294	0.132
organophosphate metabolic process	GO:0019637	195	0.129
skeletal muscle adaptation	GO:0043501	1	0.113
striated muscle myosin thick filament assembly	GO:0071688	3	0.108
cell division	GO:0051301	248	0.104
growth	GO:0040007	359	0.094
nucleoside triphosphate metabolic process	GO:0009141	120	0.090
muscle cell development	GO:0055001	50	0.086
ribonucleoside monophosphate catabolic process	GO:0009158	39	0.084
regulation of cellular component size	GO:0032535	98	0.083
actin filament based process	GO:0030029	220	0.083	Fly
myotube cell development	GO:0014904	3	0.077
cellular component assembly involved in morphogenesis	GO:0010927	151	0.074
actin cytoskeleton organization	GO:0030036	206	0.071
protein localization to organelle	GO:0033365	82	0.068
single organism intracellular transport	GO:1902582	207	0.067
nuclear transport	GO:0051169	72	0.067
oviposition	GO:0018991	19	0.066	Worm
establishment of localization in cell	GO:0051649	402	0.064
multi multicellular organism process	GO:0044706	123	0.063	Worm
cytokinesis	GO:0000910	90	0.062
nucleoside triphosphate catabolic process	GO:0009143	108	0.062
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.061
regulation of growth	GO:0040008	233	0.060
nucleocytoplasmic transport	GO:0006913	72	0.056
single organism nuclear import	GO:1902593	51	0.055
protein targeting to nucleus	GO:0044744	51	0.054
actomyosin structure organization	GO:0031032	56	0.054
positive regulation of protein import into nucleus	GO:0042307	21	0.054
positive regulation of phosphate metabolic process	GO:0045937	139	0.052
glycerol 3 phosphate metabolic process	GO:0006072	2	0.052
regulation of intracellular protein transport	GO:0033157	46	0.051
actin filament based movement	GO:0030048	26	0.050	Fly
cellular respiration	GO:0045333	26	0.050
vesicle mediated transport	GO:0016192	381	0.049
embryo development ending in birth or egg hatching	GO:0009792	152	0.049
myofibril assembly	GO:0030239	36	0.047
cellular protein complex assembly	GO:0043623	71	0.046
chaeta development	GO:0022416	97	0.045
mesoderm development	GO:0007498	78	0.045
intracellular transport	GO:0046907	228	0.043
regulation of actin filament depolymerization	GO:0030834	3	0.043
anatomical structure homeostasis	GO:0060249	97	0.042
nucleotide metabolic process	GO:0009117	161	0.042
developmental growth	GO:0048589	280	0.041
positive regulation of growth	GO:0045927	75	0.040
regulation of cytoskeleton organization	GO:0051493	89	0.040
centrosome organization	GO:0051297	163	0.040
muscle tissue morphogenesis	GO:0060415	2	0.039
cytoplasmic transport	GO:0016482	130	0.039
positive regulation of nucleoside metabolic process	GO:0045979	47	0.039
regulation of protein import into nucleus	GO:0042306	28	0.038
muscle organ development	GO:0007517	127	0.038
sarcomere organization	GO:0045214	26	0.038
syncytium formation by plasma membrane fusion	GO:0000768	43	0.038
nucleobase containing compound catabolic process	GO:0034655	165	0.037
striated muscle tissue development	GO:0014706	27	0.036
glycolytic process	GO:0006096	6	0.035
negative regulation of actin filament depolymerization	GO:0030835	2	0.035
cytoskeleton dependent cytokinesis	GO:0061640	81	0.034
extracellular matrix disassembly	GO:0022617	4	0.034
intracellular signal transduction	GO:0035556	300	0.034
aromatic compound catabolic process	GO:0019439	166	0.034
atp metabolic process	GO:0046034	49	0.033
embryonic morphogenesis	GO:0048598	206	0.033
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.031
hematopoietic progenitor cell differentiation	GO:0002244	1	0.031
establishment of protein localization to organelle	GO:0072594	62	0.031
cellular macromolecular complex assembly	GO:0034622	153	0.031
regulation of transcription factor import into nucleus	GO:0042990	22	0.030
peptidyl threonine phosphorylation	GO:0018107	2	0.030
ribose phosphate metabolic process	GO:0019693	145	0.029
protein targeting	GO:0006605	64	0.029
protein localization to nucleus	GO:0034504	55	0.029
muscle system process	GO:0003012	21	0.029
cellular protein modification process	GO:0006464	438	0.029
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.028
regulation of establishment of protein localization	GO:0070201	61	0.028
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.028
positive regulation of nucleocytoplasmic transport	GO:0046824	24	0.028
development of primary sexual characteristics	GO:0045137	50	0.027
regulation of actin filament polymerization	GO:0030833	25	0.027
tissue morphogenesis	GO:0048729	297	0.027
regulation of catabolic process	GO:0009894	170	0.027
nuclear import	GO:0051170	51	0.027
protein depolymerization	GO:0051261	31	0.027
camera type eye development	GO:0043010	4	0.027
purine containing compound metabolic process	GO:0072521	155	0.027
regulation of anatomical structure size	GO:0090066	163	0.026
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.026
posttranscriptional regulation of gene expression	GO:0010608	145	0.026
organelle assembly	GO:0070925	198	0.026
regulation of intracellular signal transduction	GO:1902531	236	0.025
protein import into nucleus	GO:0006606	51	0.025
cell motility	GO:0048870	251	0.025
purine ribonucleotide metabolic process	GO:0009150	145	0.025
protein catabolic process	GO:0030163	101	0.025
protein transport	GO:0015031	155	0.024
nucleoside monophosphate metabolic process	GO:0009123	52	0.024
ribonucleotide catabolic process	GO:0009261	109	0.024
carbohydrate derivative catabolic process	GO:1901136	118	0.024
body morphogenesis	GO:0010171	2	0.024
purine containing compound catabolic process	GO:0072523	112	0.023
ribonucleoside catabolic process	GO:0042454	112	0.023
small molecule metabolic process	GO:0044281	305	0.023
nucleoside phosphate metabolic process	GO:0006753	162	0.023
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.023
purine nucleotide catabolic process	GO:0006195	109	0.023
positive regulation of atp catabolic process	GO:1903291	3	0.022
purine nucleotide metabolic process	GO:0006163	146	0.022
glycosyl compound metabolic process	GO:1901657	127	0.022
regulation of cytoplasmic transport	GO:1903649	47	0.022
regulation of localization	GO:0032879	275	0.022
cellular nitrogen compound catabolic process	GO:0044270	165	0.022
protein complex biogenesis	GO:0070271	201	0.022
stress fiber assembly	GO:0043149	6	0.022
purine ribonucleoside catabolic process	GO:0046130	112	0.021
regulation of phosphate metabolic process	GO:0019220	210	0.021
protein complex assembly	GO:0006461	200	0.021
nucleobase containing small molecule metabolic process	GO:0055086	174	0.021
regulation of cell differentiation	GO:0045595	302	0.021
syncytium formation	GO:0006949	43	0.021
nucleoside monophosphate catabolic process	GO:0009125	39	0.021
carbohydrate derivative metabolic process	GO:1901135	217	0.021
positive regulation of purine nucleotide metabolic process	GO:1900544	55	0.020
multicellular organism growth	GO:0035264	46	0.020
muscle tissue development	GO:0060537	30	0.020
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.020
nucleoside phosphate catabolic process	GO:1901292	110	0.020
immune response	GO:0006955	246	0.020
mitotic cytokinesis	GO:0000281	50	0.020
protein polymerization	GO:0051258	42	0.020
nadh metabolic process	GO:0006734	1	0.020
localization of cell	GO:0051674	257	0.019
purine nucleoside monophosphate catabolic process	GO:0009128	38	0.019
cellular component disassembly	GO:0022411	46	0.019
positive regulation of cell adhesion	GO:0045785	10	0.019
positive regulation of hydrolase activity	GO:0051345	78	0.019
cell migration	GO:0016477	238	0.018
positive regulation of catalytic activity	GO:0043085	118	0.018
macromolecule catabolic process	GO:0009057	161	0.018
immune system process	GO:0002376	347	0.018
positive regulation of transcription factor import into nucleus	GO:0042993	19	0.018
nucleus localization	GO:0051647	34	0.018
stem cell differentiation	GO:0048863	117	0.018
regulation of nucleocytoplasmic transport	GO:0046822	35	0.017
pharynx development	GO:0060465	1	0.017
purine nucleoside metabolic process	GO:0042278	127	0.017
positive regulation of developmental process	GO:0051094	143	0.017
regulation of protein complex disassembly	GO:0043244	29	0.017
nucleoside metabolic process	GO:0009116	127	0.017
skeletal muscle organ development	GO:0060538	48	0.017
positive regulation of catabolic process	GO:0009896	105	0.017
positive regulation of cellular catabolic process	GO:0031331	95	0.016
ribonucleotide metabolic process	GO:0009259	145	0.016
actin polymerization or depolymerization	GO:0008154	31	0.016
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.016
actin filament capping	GO:0051693	2	0.016
central nervous system development	GO:0007417	201	0.016
nad metabolic process	GO:0019674	1	0.016
regulation of actin filament length	GO:0030832	27	0.016
catabolic process	GO:0009056	409	0.016
regulation of actin polymerization or depolymerization	GO:0008064	27	0.016
negative regulation of protein complex disassembly	GO:0043242	23	0.015
actin mediated cell contraction	GO:0070252	21	0.015
regulation of phosphorus metabolic process	GO:0051174	210	0.015
positive regulation of phosphorus metabolic process	GO:0010562	139	0.015
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.015
purine ribonucleotide catabolic process	GO:0009154	109	0.015
single organism catabolic process	GO:0044712	228	0.015
myosin filament assembly	GO:0031034	5	0.015
macromolecular complex assembly	GO:0065003	256	0.015
heterocycle catabolic process	GO:0046700	166	0.014
response to oxygen containing compound	GO:1901700	200	0.014
cell adhesion	GO:0007155	136	0.014
positive regulation of nucleotide catabolic process	GO:0030813	46	0.014
positive regulation of intracellular transport	GO:0032388	42	0.014
single organism cellular localization	GO:1902580	180	0.014
skeletal muscle fiber development	GO:0048741	3	0.014
glycosyl compound catabolic process	GO:1901658	112	0.014
regulation of cell morphogenesis	GO:0022604	163	0.014
regulation of developmental growth	GO:0048638	174	0.014
regulation of synapse structure and activity	GO:0050803	128	0.014
defense response to bacterium	GO:0042742	178	0.014
negative regulation of cellular component organization	GO:0051129	108	0.013
positive regulation of nfat protein import into nucleus	GO:0051533	16	0.013
purine nucleoside catabolic process	GO:0006152	112	0.013
mitotic nuclear division	GO:0007067	213	0.013
intracellular protein transport	GO:0006886	104	0.013
cellular catabolic process	GO:0044248	372	0.013
cell aging	GO:0007569	2	0.013
atp catabolic process	GO:0006200	38	0.013
regulation of protein targeting	GO:1903533	29	0.013
cell recognition	GO:0008037	102	0.013
purine ribonucleoside monophosphate catabolic process	GO:0009169	38	0.013
digestive tract development	GO:0048565	149	0.013
regulation of catalytic activity	GO:0050790	185	0.013
regulation of organelle organization	GO:0033043	196	0.013
nfat protein import into nucleus	GO:0051531	16	0.013
negative regulation of protein polymerization	GO:0032272	7	0.013
regulation of protein transport	GO:0051223	57	0.012
organic cyclic compound catabolic process	GO:1901361	168	0.012
sex differentiation	GO:0007548	81	0.012
purine ribonucleoside metabolic process	GO:0046128	127	0.012
regulation of cell shape	GO:0008360	113	0.012
generation of precursor metabolites and energy	GO:0006091	42	0.012
cardiac muscle cell differentiation	GO:0055007	4	0.012
positive regulation of protein localization to nucleus	GO:1900182	21	0.012
nucleoside catabolic process	GO:0009164	112	0.012
positive regulation of stress fiber assembly	GO:0051496	3	0.012
endocytosis	GO:0006897	310	0.012
response to oxidative stress	GO:0006979	86	0.012
reproductive structure development	GO:0048608	74	0.012
microtubule polymerization or depolymerization	GO:0031109	39	0.012
regulation of protein localization to nucleus	GO:1900180	29	0.012
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.012
regulation of protein localization	GO:0032880	76	0.012
determination of adult lifespan	GO:0008340	137	0.011
ovulation	GO:0030728	4	0.011
muscle adaptation	GO:0043500	1	0.011
positive regulation of purine nucleotide catabolic process	GO:0033123	46	0.011
establishment of protein localization	GO:0045184	163	0.011
regulation of purine nucleotide metabolic process	GO:1900542	62	0.011
somatic muscle development	GO:0007525	66	0.011
muscle contraction	GO:0006936	13	0.011
regulation of multicellular organism growth	GO:0040014	40	0.011
brain development	GO:0007420	120	0.011
positive regulation of intracellular protein transport	GO:0090316	30	0.011
phagocytosis	GO:0006909	215	0.010
neurological system process	GO:0050877	358	0.010
reproductive system development	GO:0061458	74	0.010
sensory organ morphogenesis	GO:0090596	260	0.010
regulation of purine nucleotide catabolic process	GO:0033121	48	0.010
regulation of molecular function	GO:0065009	217	0.010
organophosphate catabolic process	GO:0046434	112	0.010

Mlc1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
muscle tissue disease	DOID:66	0.149
cardiovascular system disease	DOID:1287	0.149
musculoskeletal system disease	DOID:17	0.149
disease of anatomical entity	DOID:7	0.149
cardiomyopathy	DOID:0050700	0.149
heart disease	DOID:114	0.149
muscular disease	DOID:0080000	0.149
myopathy	DOID:423	0.149
intrinsic cardiomyopathy	DOID:0060036	0.055
dilated cardiomyopathy	DOID:12930	0.035

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