IMP: Integrative Multi-species Prediction

Drosophila melanogaster

52 known processes

PEK (Dmel_CG2087)

pancreatic eIF-2alpha kinase

(Aliases: CG2087,PERK,EIF2-like,DPERK,DpERK,Perk,DmPEK,Dmel\CG2087)

Entrez: 40653
FLYBASE: FBgn0037327
UniProtKB: Q9NIV1

Process Predictions
Disease Predictions

PEK biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
developmental programmed cell death	GO:0010623	138	0.303
single organism catabolic process	GO:0044712	228	0.293
regulation of cellular catabolic process	GO:0031329	157	0.291
heterocycle catabolic process	GO:0046700	166	0.239
regulation of mitotic cell cycle	GO:0007346	190	0.230
nucleotide metabolic process	GO:0009117	161	0.223
compound eye development	GO:0048749	307	0.212
positive regulation of cell communication	GO:0010647	250	0.193	Mouse
neurological system process	GO:0050877	358	0.181	Mouse
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.169	Mouse
death	GO:0016265	284	0.168	Mouse Worm
intracellular signal transduction	GO:0035556	300	0.165	Mouse
response to biotic stimulus	GO:0009607	294	0.137	Human
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.126	Mouse
purine containing compound metabolic process	GO:0072521	155	0.121
organophosphate metabolic process	GO:0019637	195	0.110
negative regulation of cellular metabolic process	GO:0031324	382	0.107	Mouse Rat
purine ribonucleotide metabolic process	GO:0009150	145	0.106
nucleobase containing compound catabolic process	GO:0034655	165	0.105
negative regulation of multicellular organismal process	GO:0051241	142	0.104	Mouse
compound eye morphogenesis	GO:0001745	249	0.097
regulation of cell cycle	GO:0051726	291	0.088
regulation of response to stress	GO:0080134	200	0.086	Mouse
organonitrogen compound metabolic process	GO:1901564	318	0.081
positive regulation of signaling	GO:0023056	243	0.081	Mouse
positive regulation of rna metabolic process	GO:0051254	271	0.076	Mouse
chromosome organization	GO:0051276	360	0.076
organic substance catabolic process	GO:1901575	308	0.075
purine ribonucleoside metabolic process	GO:0046128	127	0.075
regulation of catabolic process	GO:0009894	170	0.072
programmed cell death	GO:0012501	257	0.072	Mouse
positive regulation of nervous system development	GO:0051962	69	0.072
response to other organism	GO:0051707	293	0.072
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.071
positive regulation of response to stimulus	GO:0048584	323	0.071	Mouse
positive regulation of biosynthetic process	GO:0009891	316	0.071	Mouse
phagocytosis	GO:0006909	215	0.070
sensory organ morphogenesis	GO:0090596	260	0.070
defense response to other organism	GO:0098542	225	0.070
response to oxygen containing compound	GO:1901700	200	0.068
immune system process	GO:0002376	347	0.068
regulation of protein metabolic process	GO:0051246	256	0.067	Mouse Rat
nucleobase containing small molecule metabolic process	GO:0055086	174	0.065
establishment of localization in cell	GO:0051649	402	0.065
response to temperature stimulus	GO:0009266	106	0.065
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.064
defense response	GO:0006952	300	0.063
regulation of erbb signaling pathway	GO:1901184	42	0.062
regulation of phosphorus metabolic process	GO:0051174	210	0.060
glycosyl compound metabolic process	GO:1901657	127	0.060
response to external biotic stimulus	GO:0043207	293	0.060
cell death	GO:0008219	279	0.059	Mouse Worm
eye development	GO:0001654	323	0.059
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.059
positive regulation of programmed cell death	GO:0043068	62	0.058	Mouse
regulation of immune response	GO:0050776	118	0.057
purine ribonucleoside catabolic process	GO:0046130	112	0.055
regulation of cell differentiation	GO:0045595	302	0.054
post embryonic appendage morphogenesis	GO:0035120	385	0.053
head development	GO:0060322	135	0.053
chromatin modification	GO:0016568	147	0.052
nucleoside catabolic process	GO:0009164	112	0.052
ribonucleotide metabolic process	GO:0009259	145	0.052
protein modification process	GO:0036211	438	0.051
vesicle mediated transport	GO:0016192	381	0.050
cellular catabolic process	GO:0044248	372	0.050
regulation of catalytic activity	GO:0050790	185	0.050	Mouse
brain development	GO:0007420	120	0.050
regulation of r7 cell differentiation	GO:0045676	15	0.049
purine nucleotide metabolic process	GO:0006163	146	0.049
nucleoside metabolic process	GO:0009116	127	0.048
phosphorylation	GO:0016310	294	0.047
atp metabolic process	GO:0046034	49	0.047
immune response	GO:0006955	246	0.047
ribonucleoside catabolic process	GO:0042454	112	0.047
ommatidial rotation	GO:0016318	20	0.046
organic substance transport	GO:0071702	257	0.046
forebrain development	GO:0030900	2	0.046
nucleoside phosphate metabolic process	GO:0006753	162	0.045
purine nucleoside catabolic process	GO:0006152	112	0.045
camera type eye development	GO:0043010	4	0.045
regulation of nucleotide metabolic process	GO:0006140	62	0.045
regulation of programmed cell death	GO:0043067	152	0.044	Mouse
endocytosis	GO:0006897	310	0.044
organic cyclic compound catabolic process	GO:1901361	168	0.041
regulation of phosphate metabolic process	GO:0019220	210	0.041
body morphogenesis	GO:0010171	2	0.041
catabolic process	GO:0009056	409	0.041
developmental growth	GO:0048589	280	0.041
taxis	GO:0042330	304	0.040
eye photoreceptor cell differentiation	GO:0001754	145	0.040
regulation of ras protein signal transduction	GO:0046578	93	0.040
defense response to bacterium	GO:0042742	178	0.039
cellular nitrogen compound catabolic process	GO:0044270	165	0.039
carbohydrate derivative catabolic process	GO:1901136	118	0.039
nucleoside triphosphate metabolic process	GO:0009141	120	0.039
positive regulation of signal transduction	GO:0009967	223	0.039	Mouse
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.038
regulation of cell cycle g1 s phase transition	GO:1902806	23	0.038
aromatic compound catabolic process	GO:0019439	166	0.038
regulation of cell cycle process	GO:0010564	181	0.038
branched chain amino acid transport	GO:0015803	3	0.038
ribonucleotide catabolic process	GO:0009261	109	0.038
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.037
regulation of apoptotic process	GO:0042981	130	0.037	Mouse
synaptic transmission	GO:0007268	288	0.036
response to abiotic stimulus	GO:0009628	341	0.036
morphogenesis of a branching epithelium	GO:0061138	45	0.036
regulation of developmental growth	GO:0048638	174	0.036
ribose phosphate metabolic process	GO:0019693	145	0.035
regulation of molecular function	GO:0065009	217	0.035	Mouse
telencephalon development	GO:0021537	2	0.035
tissue morphogenesis	GO:0048729	297	0.035
photoreceptor cell differentiation	GO:0046530	170	0.034
transcription from rna polymerase ii promoter	GO:0006366	368	0.033	Mouse
purine nucleoside metabolic process	GO:0042278	127	0.033
regulation of intracellular signal transduction	GO:1902531	236	0.033	Mouse
single organism biosynthetic process	GO:0044711	206	0.033
positive regulation of macromolecule metabolic process	GO:0010604	405	0.032	Mouse
nucleoside triphosphate catabolic process	GO:0009143	108	0.032
response to lipopolysaccharide	GO:0032496	4	0.032
carbohydrate derivative metabolic process	GO:1901135	217	0.032
acid secretion	GO:0046717	1	0.032
cell proliferation	GO:0008283	299	0.031
establishment of organelle localization	GO:0051656	122	0.031
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.031	Mouse Rat
establishment of tissue polarity	GO:0007164	87	0.031
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.030	Mouse
cellular macromolecule catabolic process	GO:0044265	136	0.030
modification dependent protein catabolic process	GO:0019941	78	0.030
establishment of planar polarity	GO:0001736	87	0.029
embryonic organ development	GO:0048568	50	0.029
defense response to gram negative bacterium	GO:0050829	94	0.029
regulation of nucleoside metabolic process	GO:0009118	50	0.029
regulation of hydrolase activity	GO:0051336	97	0.029	Mouse
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.029	Mouse
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.029
secretion	GO:0046903	109	0.029	Mouse
regulation of immune system process	GO:0002682	176	0.028
protein transport	GO:0015031	155	0.028
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.028
purine nucleotide catabolic process	GO:0006195	109	0.028
wing disc morphogenesis	GO:0007472	344	0.028
posttranscriptional regulation of gene expression	GO:0010608	145	0.028	Mouse Rat
positive regulation of purine nucleotide metabolic process	GO:1900544	55	0.027
regulation of anatomical structure size	GO:0090066	163	0.027
intracellular transport	GO:0046907	228	0.027
positive regulation of catabolic process	GO:0009896	105	0.027
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.027
homeostatic process	GO:0042592	199	0.026
regulation of nervous system development	GO:0051960	248	0.026	Mouse
salivary gland development	GO:0007431	162	0.025
extrinsic apoptotic signaling pathway	GO:0097191	1	0.025
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.025	Mouse
purine containing compound catabolic process	GO:0072523	112	0.025
morphogenesis of a polarized epithelium	GO:0001738	93	0.025
regionalization	GO:0003002	416	0.025
oxoacid metabolic process	GO:0043436	103	0.024	Mouse
response to extracellular stimulus	GO:0009991	116	0.024
regulation of cellular amine metabolic process	GO:0033238	3	0.023
regulation of neurogenesis	GO:0050767	158	0.023
pigment metabolic process	GO:0042440	84	0.023
positive regulation of cell differentiation	GO:0045597	64	0.023
positive regulation of cellular catabolic process	GO:0031331	95	0.022
dna metabolic process	GO:0006259	227	0.022
cellular macromolecule localization	GO:0070727	220	0.022
negative regulation of developmental growth	GO:0048640	64	0.022
regulation of mitotic sister chromatid separation	GO:0010965	28	0.022
regulation of growth	GO:0040008	233	0.022	Worm
small gtpase mediated signal transduction	GO:0007264	88	0.022
eye morphogenesis	GO:0048592	260	0.021
stem cell differentiation	GO:0048863	117	0.021
endomembrane system organization	GO:0010256	119	0.021	Mouse
memory	GO:0007613	94	0.021
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.021	Mouse
innate immune response	GO:0045087	144	0.021
apoptotic process	GO:0006915	159	0.021	Mouse
establishment or maintenance of cell polarity	GO:0007163	167	0.021
nucleotide catabolic process	GO:0009166	109	0.021
regulation of cell death	GO:0010941	173	0.021	Mouse Worm
regulation of purine nucleotide metabolic process	GO:1900542	62	0.021
nucleoside monophosphate metabolic process	GO:0009123	52	0.020
aging	GO:0007568	143	0.020	Worm
ribonucleoside metabolic process	GO:0009119	127	0.020
response to heat	GO:0009408	63	0.020
cell cycle checkpoint	GO:0000075	95	0.020
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.019	Mouse
epithelial cell development	GO:0002064	274	0.019
organonitrogen compound biosynthetic process	GO:1901566	117	0.019
purine ribonucleotide catabolic process	GO:0009154	109	0.019
macromolecule catabolic process	GO:0009057	161	0.019
negative regulation of cell proliferation	GO:0008285	69	0.019
positive regulation of phosphorus metabolic process	GO:0010562	139	0.019
regulation of organ morphogenesis	GO:2000027	78	0.019
nitrogen compound transport	GO:0071705	85	0.019
growth	GO:0040007	359	0.019	Worm
single organism intracellular transport	GO:1902582	207	0.018
gtp catabolic process	GO:0006184	72	0.018
mitotic cell cycle phase transition	GO:0044772	138	0.018
negative regulation of cell development	GO:0010721	62	0.018
regulation of innate immune response	GO:0045088	71	0.018
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.018
proteasomal protein catabolic process	GO:0010498	59	0.018
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.018
regulation of cell development	GO:0060284	215	0.018
positive regulation of rna biosynthetic process	GO:1902680	266	0.018	Mouse
regulation of organelle organization	GO:0033043	196	0.018
positive regulation of cellular biosynthetic process	GO:0031328	316	0.017	Mouse
negative regulation of cell differentiation	GO:0045596	143	0.017
organonitrogen compound catabolic process	GO:1901565	128	0.017
positive regulation of cell death	GO:0010942	69	0.017	Mouse
negative regulation of apoptotic process	GO:0043066	63	0.017	Mouse
regulation of immune effector process	GO:0002697	52	0.017
imaginal disc pattern formation	GO:0007447	91	0.017
guanosine containing compound catabolic process	GO:1901069	74	0.017
mitotic nuclear division	GO:0007067	213	0.017
lipid localization	GO:0010876	54	0.017
skin development	GO:0043588	65	0.017
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.016
chemosensory behavior	GO:0007635	106	0.016
tube morphogenesis	GO:0035239	191	0.016
secretion by cell	GO:0032940	101	0.016
small molecule metabolic process	GO:0044281	305	0.016	Mouse
compound eye photoreceptor cell differentiation	GO:0001751	140	0.016
r3 r4 cell differentiation	GO:0048056	12	0.016
regulation of intracellular transport	GO:0032386	64	0.016
dorsal ventral axis specification ovarian follicular epithelium	GO:0008069	13	0.016
organophosphate catabolic process	GO:0046434	112	0.016
vesicle organization	GO:0016050	44	0.016
notch signaling pathway	GO:0007219	120	0.016
positive regulation of multicellular organismal process	GO:0051240	143	0.016
regulation of cellular localization	GO:0060341	136	0.016
regulation of organ growth	GO:0046620	42	0.016
actin filament organization	GO:0007015	126	0.015
proteolysis	GO:0006508	192	0.015	Mouse
gland development	GO:0048732	191	0.015	Mouse
positive regulation of developmental process	GO:0051094	143	0.015
spindle organization	GO:0007051	253	0.015
response to nutrient levels	GO:0031667	114	0.015
salivary gland morphogenesis	GO:0007435	145	0.015
negative regulation of programmed cell death	GO:0043069	72	0.015	Mouse
appendage morphogenesis	GO:0035107	397	0.015
positive regulation of transcription dna templated	GO:0045893	266	0.015	Mouse
regulation of gene expression epigenetic	GO:0040029	128	0.014
branching morphogenesis of an epithelial tube	GO:0048754	45	0.014
autophagic cell death	GO:0048102	83	0.014
regulation of gtp catabolic process	GO:0033124	44	0.014
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.014
carboxylic acid metabolic process	GO:0019752	92	0.014	Mouse
response to bacterium	GO:0009617	198	0.014
positive regulation of phosphate metabolic process	GO:0045937	139	0.014
regulation of phosphorylation	GO:0042325	147	0.014
dna integrity checkpoint	GO:0031570	81	0.014
negative regulation of developmental process	GO:0051093	201	0.014	Mouse
respiratory system development	GO:0060541	213	0.014
gland morphogenesis	GO:0022612	145	0.014
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.014
positive regulation of gene expression	GO:0010628	290	0.014	Mouse
regulation of notch signaling pathway	GO:0008593	100	0.014
positive regulation of cellular component biogenesis	GO:0044089	80	0.014
regulation of multicellular organismal development	GO:2000026	414	0.014	Mouse
negative regulation of response to stimulus	GO:0048585	258	0.014
modification dependent macromolecule catabolic process	GO:0043632	79	0.014
epithelial cell differentiation	GO:0030855	322	0.014
ras protein signal transduction	GO:0007265	88	0.014
eggshell formation	GO:0030703	105	0.013
mitotic dna damage checkpoint	GO:0044773	74	0.013
male gamete generation	GO:0048232	201	0.013
negative regulation of phosphate metabolic process	GO:0045936	45	0.013
cell cycle g1 s phase transition	GO:0044843	31	0.013
atp catabolic process	GO:0006200	38	0.013
negative regulation of transcription dna templated	GO:0045892	237	0.013
cellular amino acid metabolic process	GO:0006520	61	0.013
positive regulation of apoptotic process	GO:0043065	47	0.013	Mouse
connective tissue development	GO:0061448	3	0.013	Mouse
negative regulation of signal transduction	GO:0009968	206	0.013
lateral inhibition	GO:0046331	206	0.013
mesenchymal cell development	GO:0014031	1	0.013
establishment of protein localization	GO:0045184	163	0.013
positive regulation of nucleotide catabolic process	GO:0030813	46	0.013
cellular protein modification process	GO:0006464	438	0.013
positive regulation of organelle organization	GO:0010638	65	0.013
cell type specific apoptotic process	GO:0097285	38	0.013
positive regulation of molecular function	GO:0044093	136	0.013	Mouse
protein phosphorylation	GO:0006468	169	0.012
nucleoside phosphate catabolic process	GO:1901292	110	0.012
positive regulation of protein metabolic process	GO:0051247	128	0.012	Mouse
regulation of proteolysis	GO:0030162	87	0.012	Mouse
negative regulation of immune system process	GO:0002683	50	0.012
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.012
negative regulation of cell cycle phase transition	GO:1901988	103	0.012
dorsal ventral axis specification	GO:0009950	66	0.012
regulation of secretion	GO:0051046	44	0.012
erbb signaling pathway	GO:0038127	58	0.012
developmental pigmentation	GO:0048066	68	0.012
organelle localization	GO:0051640	148	0.012
imaginal disc derived appendage development	GO:0048737	399	0.012
positive regulation of exocytosis	GO:0045921	4	0.012
regulation of photoreceptor cell differentiation	GO:0046532	34	0.012
regulation of cellular component size	GO:0032535	98	0.012
carbohydrate derivative biosynthetic process	GO:1901137	85	0.012
signal transduction by phosphorylation	GO:0023014	107	0.011
imaginal disc growth	GO:0007446	37	0.011
regulation of purine nucleotide catabolic process	GO:0033121	48	0.011
negative regulation of nervous system development	GO:0051961	92	0.011	Mouse
regulation of g1 s transition of mitotic cell cycle	GO:2000045	23	0.011
nuclear division	GO:0000280	332	0.011
exocytosis	GO:0006887	28	0.011
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.011
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.011
negative regulation of cellular protein metabolic process	GO:0032269	85	0.011	Mouse Rat
cell cycle phase transition	GO:0044770	140	0.011
intracellular protein transport	GO:0006886	104	0.011
response to metal ion	GO:0010038	23	0.011
positive regulation of phosphorylation	GO:0042327	87	0.011
dorsal ventral pattern formation	GO:0009953	133	0.011
salivary gland cell autophagic cell death	GO:0035071	83	0.011
morphogenesis of an epithelium	GO:0002009	276	0.011
establishment of protein localization to organelle	GO:0072594	62	0.011
glycosyl compound catabolic process	GO:1901658	112	0.011
anion transport	GO:0006820	41	0.011
cellular response to biotic stimulus	GO:0071216	4	0.011	Human
positive regulation of purine nucleotide catabolic process	GO:0033123	46	0.011
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.011
regulation of hippo signaling	GO:0035330	14	0.010
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.010
protein localization	GO:0008104	284	0.010
tissue death	GO:0016271	102	0.010
positive regulation of cellular protein metabolic process	GO:0032270	118	0.010	Mouse
embryonic morphogenesis	GO:0048598	206	0.010

PEK disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.047
disease of anatomical entity	DOID:7	0.041
cancer	DOID:162	0.035
organ system cancer	DOID:0050686	0.035

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