IMP: Integrative Multi-species Prediction

Drosophila melanogaster

13 known processes

Rpt1 (Dmel_CG1341)

CG1341 gene product from transcript CG1341-RA

(Aliases: Dm_Rpt1,Rpt1/p48B,Dmel\CG1341,CG1341,1341,dRpt1,l(2)43Ed,l(2)05643,anon-WO0118547.90,Dmp48B,p48B)

Entrez: 35701
FLYBASE: FBgn0028687
UniProtKB: Q7KMQ0

Process Predictions
Disease Predictions

Rpt1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
proteolysis	GO:0006508	192	0.943
modification dependent macromolecule catabolic process	GO:0043632	79	0.942	Human Yeast
catabolic process	GO:0009056	409	0.882	Human Yeast
cellular macromolecule catabolic process	GO:0044265	136	0.881	Human Yeast
protein complex assembly	GO:0006461	200	0.869	Yeast
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.852	Human Yeast
positive regulation of proteolysis	GO:0045862	52	0.839
modification dependent protein catabolic process	GO:0019941	78	0.818	Human Yeast
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.817
positive regulation of peptidase activity	GO:0010952	29	0.779
protein complex biogenesis	GO:0070271	201	0.751	Yeast
cellular catabolic process	GO:0044248	372	0.742	Human Yeast
nuclear division	GO:0000280	332	0.720
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.718
regulation of endopeptidase activity	GO:0052548	36	0.713
ubiquitin dependent protein catabolic process	GO:0006511	78	0.706	Human Yeast
aging	GO:0007568	143	0.704	Worm
positive regulation of endopeptidase activity	GO:0010950	26	0.650
cellular response to dna damage stimulus	GO:0006974	223	0.611
cellular protein catabolic process	GO:0044257	83	0.602	Human Yeast
determination of adult lifespan	GO:0008340	137	0.596	Worm
regulation of proteolysis	GO:0030162	87	0.570
mitotic spindle organization	GO:0007052	220	0.544
proteasomal protein catabolic process	GO:0010498	59	0.502
regulation of cellular component biogenesis	GO:0044087	201	0.490	Yeast
multicellular organismal aging	GO:0010259	140	0.469	Worm
macromolecular complex assembly	GO:0065003	256	0.454	Yeast
organic substance catabolic process	GO:1901575	308	0.446	Human Yeast
regulation of peptidase activity	GO:0052547	39	0.436
spindle organization	GO:0007051	253	0.401
spindle assembly	GO:0051225	80	0.391
cell death	GO:0008219	279	0.377
apoptotic process	GO:0006915	159	0.371
programmed cell death	GO:0012501	257	0.363
cellular protein complex assembly	GO:0043623	71	0.363	Yeast
transcription from rna polymerase ii promoter	GO:0006366	368	0.350	Yeast
regulation of cellular protein metabolic process	GO:0032268	243	0.340
mitotic spindle elongation	GO:0000022	81	0.338
proteasome assembly	GO:0043248	2	0.327	Yeast
microtubule cytoskeleton organization involved in mitosis	GO:1902850	52	0.319
organelle fission	GO:0048285	340	0.312
macromolecule catabolic process	GO:0009057	161	0.307	Human Yeast
protein catabolic process	GO:0030163	101	0.298	Human Yeast
dna templated transcription elongation	GO:0006354	18	0.288
cellular nitrogen compound catabolic process	GO:0044270	165	0.280	Human
negative regulation of cellular metabolic process	GO:0031324	382	0.265
regulation of proteasomal protein catabolic process	GO:0061136	39	0.251
death	GO:0016265	284	0.244
chromosome organization	GO:0051276	360	0.243
cellular macromolecular complex assembly	GO:0034622	153	0.238	Yeast
chromosome segregation	GO:0007059	157	0.214
ribonucleoside monophosphate catabolic process	GO:0009158	39	0.213	Human
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.208	Yeast
spindle assembly involved in mitosis	GO:0090307	50	0.205
er associated ubiquitin dependent protein catabolic process	GO:0030433	3	0.203
mitotic nuclear division	GO:0007067	213	0.197
embryo development ending in birth or egg hatching	GO:0009792	152	0.181	Worm
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.178
dna metabolic process	GO:0006259	227	0.164
regulation of cellular ketone metabolic process	GO:0010565	3	0.161
larval development	GO:0002164	104	0.158	Worm
response to organic substance	GO:0010033	284	0.152
positive regulation of cellular protein metabolic process	GO:0032270	118	0.152
purine nucleoside catabolic process	GO:0006152	112	0.148	Human
organelle assembly	GO:0070925	198	0.140
dna templated transcription initiation	GO:0006352	25	0.138	Yeast
aromatic compound catabolic process	GO:0019439	166	0.135	Human
nucleobase containing compound catabolic process	GO:0034655	165	0.132	Human
positive regulation of cellular component biogenesis	GO:0044089	80	0.132	Yeast
cell motility	GO:0048870	251	0.132
positive regulation of protein metabolic process	GO:0051247	128	0.131	Yeast
positive regulation of proteolysis involved in cellular protein catabolic process	GO:1903052	24	0.131
regulation of cell cycle	GO:0051726	291	0.129
positive regulation of cellular biosynthetic process	GO:0031328	316	0.127	Yeast
regulation of cellular catabolic process	GO:0031329	157	0.126
sister chromatid segregation	GO:0000819	92	0.126
regulation of phosphate metabolic process	GO:0019220	210	0.124
positive regulation of rna biosynthetic process	GO:1902680	266	0.121	Yeast
dna repair	GO:0006281	54	0.119
cell proliferation	GO:0008283	299	0.118
negative regulation of gene expression	GO:0010629	387	0.116
spindle elongation	GO:0051231	83	0.113
negative regulation of signaling	GO:0023057	219	0.112
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.111	Yeast
cell division	GO:0051301	248	0.110
heterocycle catabolic process	GO:0046700	166	0.109	Human
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.107	Yeast
regulation of mitosis	GO:0007088	56	0.107
positive regulation of macromolecule metabolic process	GO:0010604	405	0.105	Yeast
ribonucleoside metabolic process	GO:0009119	127	0.104	Human
negative regulation of biosynthetic process	GO:0009890	277	0.101
regulation of protein metabolic process	GO:0051246	256	0.100	Yeast
regulation of cell division	GO:0051302	72	0.100
regulation of cell cycle process	GO:0010564	181	0.095
nucleoside triphosphate catabolic process	GO:0009143	108	0.092	Human
positive regulation of hydrolase activity	GO:0051345	78	0.090
rna catabolic process	GO:0006401	37	0.088
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.088	Yeast
purine ribonucleoside catabolic process	GO:0046130	112	0.085	Human
positive regulation of biosynthetic process	GO:0009891	316	0.085	Yeast
regulation of cell death	GO:0010941	173	0.084
regulation of molecular function	GO:0065009	217	0.083
positive regulation of proteasomal protein catabolic process	GO:1901800	20	0.083
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.081	Human
activation of cysteine type endopeptidase activity involved in apoptotic process	GO:0006919	16	0.078
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.077	Human
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.077	Human
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.076	Yeast
chemotaxis	GO:0006935	249	0.075
positive regulation of molecular function	GO:0044093	136	0.075
regulation of catalytic activity	GO:0050790	185	0.075
negative regulation of cell communication	GO:0010648	223	0.073
regulation of cellular protein catabolic process	GO:1903362	44	0.072
positive regulation of cellular catabolic process	GO:0031331	95	0.072
nucleoside metabolic process	GO:0009116	127	0.071	Human
negative regulation of signal transduction	GO:0009968	206	0.071
phosphorylation	GO:0016310	294	0.071
regulation of catabolic process	GO:0009894	170	0.069	Yeast
regulation of hydrolase activity	GO:0051336	97	0.066
positive regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032436	19	0.066
taxis	GO:0042330	304	0.065
regulation of dna templated transcription elongation	GO:0032784	17	0.064
regulation of phosphorus metabolic process	GO:0051174	210	0.064
cellular ketone metabolic process	GO:0042180	24	0.064
ribonucleotide catabolic process	GO:0009261	109	0.062	Human
intracellular signal transduction	GO:0035556	300	0.062
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.061	Human
positive regulation of cell death	GO:0010942	69	0.060
regulation of nuclear division	GO:0051783	58	0.060
carbohydrate derivative catabolic process	GO:1901136	118	0.060	Human
embryonic morphogenesis	GO:0048598	206	0.060
transcription elongation from rna polymerase ii promoter	GO:0006368	18	0.058
positive regulation of cellular component organization	GO:0051130	156	0.055	Yeast
single organism catabolic process	GO:0044712	228	0.054	Human
lipid modification	GO:0030258	24	0.054
tube development	GO:0035295	244	0.054
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.053	Human
chromatin organization	GO:0006325	207	0.053
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.052	Human
nucleotide metabolic process	GO:0009117	161	0.051	Human
regulation of apoptotic process	GO:0042981	130	0.051
positive regulation of programmed cell death	GO:0043068	62	0.051
regulation of rna polymerase ii transcriptional preinitiation complex assembly	GO:0045898	1	0.051	Yeast
autophagy	GO:0006914	108	0.049
purine nucleotide metabolic process	GO:0006163	146	0.048	Human
ribose phosphate metabolic process	GO:0019693	145	0.047	Human
rna polymerase ii transcriptional preinitiation complex assembly	GO:0051123	20	0.047	Yeast
positive regulation of catalytic activity	GO:0043085	118	0.047
nucleoside catabolic process	GO:0009164	112	0.047	Human
camera type eye development	GO:0043010	4	0.047
microtubule organizing center organization	GO:0031023	168	0.046
mitotic cell cycle phase transition	GO:0044772	138	0.045
negative regulation of multicellular organismal process	GO:0051241	142	0.045
carbohydrate derivative metabolic process	GO:1901135	217	0.045	Human
cell migration	GO:0016477	238	0.045
telencephalon development	GO:0021537	2	0.044
protein dna complex assembly	GO:0065004	63	0.044	Yeast
dna templated transcriptional preinitiation complex assembly	GO:0070897	20	0.042	Yeast
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.042	Human
mitotic sister chromatid separation	GO:0051306	30	0.041
regulation of mitotic cell cycle	GO:0007346	190	0.041
biological adhesion	GO:0022610	138	0.040
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.040
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.039
positive regulation of transcription dna templated	GO:0045893	266	0.039	Yeast
epithelial cell differentiation	GO:0030855	322	0.038
nucleotide excision repair	GO:0006289	8	0.038
regulation of programmed cell death	GO:0043067	152	0.037
purine ribonucleotide metabolic process	GO:0009150	145	0.037	Human
response to oxygen containing compound	GO:1901700	200	0.037
regulation of phosphorylation	GO:0042325	147	0.037
glycosyl compound catabolic process	GO:1901658	112	0.037	Human
sensory organ morphogenesis	GO:0090596	260	0.036
regulation of response to stress	GO:0080134	200	0.036
organophosphate metabolic process	GO:0019637	195	0.036	Human
negative regulation of transcription dna templated	GO:0045892	237	0.035
response to nitrogen compound	GO:1901698	90	0.035
regulation of multicellular organismal development	GO:2000026	414	0.035
response to endogenous stimulus	GO:0009719	119	0.035
chromatin remodeling	GO:0006338	72	0.035
forebrain development	GO:0030900	2	0.034
response to biotic stimulus	GO:0009607	294	0.034
centrosome organization	GO:0051297	163	0.034
spinal cord development	GO:0021510	1	0.034
chromatin modification	GO:0016568	147	0.033
positive regulation of phosphorus metabolic process	GO:0010562	139	0.033
appendage morphogenesis	GO:0035107	397	0.033
purine containing compound metabolic process	GO:0072521	155	0.033	Human
imaginal disc derived wing morphogenesis	GO:0007476	337	0.033
negative regulation of cell proliferation	GO:0008285	69	0.033
nucleoside monophosphate metabolic process	GO:0009123	52	0.033	Human
purine nucleoside metabolic process	GO:0042278	127	0.032	Human
purine nucleoside monophosphate catabolic process	GO:0009128	38	0.031	Human
phagocytosis	GO:0006909	215	0.031
tissue morphogenesis	GO:0048729	297	0.031
protein dna complex subunit organization	GO:0071824	86	0.030	Yeast
negative regulation of rna biosynthetic process	GO:1902679	240	0.030
purine ribonucleotide catabolic process	GO:0009154	109	0.030	Human
regulation of mitotic sister chromatid segregation	GO:0033047	28	0.029
nuclear transcribed mrna catabolic process nonsense mediated decay	GO:0000184	8	0.029
mitotic sister chromatid segregation	GO:0000070	87	0.028
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.028
atp metabolic process	GO:0046034	49	0.028	Human
regulation of cell differentiation	GO:0045595	302	0.028
regulation of protein complex assembly	GO:0043254	42	0.028	Yeast
response to other organism	GO:0051707	293	0.028
sex differentiation	GO:0007548	81	0.027
synapse organization	GO:0050808	196	0.027
nucleoside phosphate metabolic process	GO:0006753	162	0.027	Human
cell cycle phase transition	GO:0044770	140	0.026
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.025	Human
protein ubiquitination	GO:0016567	70	0.025
mrna cis splicing via spliceosome	GO:0045292	1	0.025
organic cyclic compound catabolic process	GO:1901361	168	0.025	Human
morphogenesis of an epithelium	GO:0002009	276	0.025
homeostatic process	GO:0042592	199	0.025
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	23	0.024
response to organonitrogen compound	GO:0010243	75	0.024
organic substance transport	GO:0071702	257	0.024
cell adhesion	GO:0007155	136	0.024
nucleoside phosphate catabolic process	GO:1901292	110	0.024	Human
tube morphogenesis	GO:0035239	191	0.024
cellular lipid metabolic process	GO:0044255	83	0.024
response to organic cyclic compound	GO:0014070	89	0.023
meiotic cell cycle	GO:0051321	171	0.023
ras protein signal transduction	GO:0007265	88	0.022
cellular response to chemical stimulus	GO:0070887	199	0.022
body morphogenesis	GO:0010171	2	0.022
single organism behavior	GO:0044708	391	0.022
negative regulation of protein metabolic process	GO:0051248	85	0.022
double strand break repair	GO:0006302	26	0.022
cell maturation	GO:0048469	144	0.022
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	25	0.021
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.021	Yeast
mapk cascade	GO:0000165	107	0.021
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.021
lipid metabolic process	GO:0006629	121	0.021
nucleoside triphosphate metabolic process	GO:0009141	120	0.021	Human
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	4	0.021
regulation of chromosome segregation	GO:0051983	32	0.020
small molecule metabolic process	GO:0044281	305	0.020	Human
regulation of immune system process	GO:0002682	176	0.020
developmental maturation	GO:0021700	172	0.020
protein processing	GO:0016485	68	0.020
wing disc morphogenesis	GO:0007472	344	0.020
appendage development	GO:0048736	401	0.020
negative regulation of rna metabolic process	GO:0051253	251	0.020
regulation of ras protein signal transduction	GO:0046578	93	0.020
positive regulation of apoptotic process	GO:0043065	47	0.020
glycosyl compound metabolic process	GO:1901657	127	0.020	Human
regulation of organelle organization	GO:0033043	196	0.019
regulation of protein catabolic process	GO:0042176	55	0.019	Yeast
positive regulation of gene expression	GO:0010628	290	0.019	Yeast
protein maturation	GO:0051604	71	0.019
small gtpase mediated signal transduction	GO:0007264	88	0.019
regulation of cell proliferation	GO:0042127	163	0.019
immune system process	GO:0002376	347	0.019
ribonucleoside catabolic process	GO:0042454	112	0.019	Human
regulation of response to biotic stimulus	GO:0002831	63	0.019
response to starvation	GO:0042594	97	0.018
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.018	Human
purine ribonucleoside monophosphate catabolic process	GO:0009169	38	0.018	Human
response to extracellular stimulus	GO:0009991	116	0.018
regulation of organ morphogenesis	GO:2000027	78	0.018
carboxylic acid metabolic process	GO:0019752	92	0.018
protein neddylation	GO:0045116	5	0.018
protein import into nucleus	GO:0006606	51	0.018
positive regulation of response to stimulus	GO:0048584	323	0.018
cellular response to extracellular stimulus	GO:0031668	64	0.018
male gamete generation	GO:0048232	201	0.017
lateral inhibition	GO:0046331	206	0.017
positive regulation of phosphate metabolic process	GO:0045937	139	0.017
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process	GO:0031145	30	0.017
positive regulation of signal transduction	GO:0009967	223	0.017
purine ribonucleoside metabolic process	GO:0046128	127	0.017	Human
regulation of localization	GO:0032879	275	0.017
eye development	GO:0001654	323	0.017
regulation of protein modification process	GO:0031399	112	0.017
positive regulation of rna metabolic process	GO:0051254	271	0.017	Yeast
regulation of sister chromatid segregation	GO:0033045	28	0.017
regulation of cell development	GO:0060284	215	0.016
epithelial tube morphogenesis	GO:0060562	88	0.016
regulation of cell projection organization	GO:0031344	92	0.016
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.016
regulation of establishment of protein localization	GO:0070201	61	0.016
positive regulation of catabolic process	GO:0009896	105	0.016	Yeast
regulation of epithelial cell proliferation	GO:0050678	4	0.016
vesicle mediated transport	GO:0016192	381	0.016
response to wounding	GO:0009611	94	0.016
oxoacid metabolic process	GO:0043436	103	0.016
regulation of transcription elongation from rna polymerase ii promoter	GO:0034243	15	0.016
organophosphate catabolic process	GO:0046434	112	0.015	Human
cell recognition	GO:0008037	102	0.015
positive regulation of cell migration	GO:0030335	2	0.015
regulation of behavior	GO:0050795	75	0.015
transcription initiation from rna polymerase ii promoter	GO:0006367	25	0.015	Yeast
negative regulation of growth	GO:0045926	84	0.015
protein modification by small protein conjugation or removal	GO:0070647	106	0.015
positive regulation of cell motility	GO:2000147	3	0.015
chromosome separation	GO:0051304	42	0.015
drinking behavior	GO:0042756	2	0.015
protein transport	GO:0015031	155	0.015
positive regulation of cell communication	GO:0010647	250	0.015
ubiquitin homeostasis	GO:0010992	1	0.014
intracellular transport	GO:0046907	228	0.014
negative regulation of proteolysis	GO:0045861	31	0.014
regulation of gene expression epigenetic	GO:0040029	128	0.014
organonitrogen compound catabolic process	GO:1901565	128	0.014	Human
positive regulation of cysteine type endopeptidase activity	GO:2001056	24	0.014
endocytosis	GO:0006897	310	0.014
transmembrane transport	GO:0055085	139	0.013
regulation of cellular amine metabolic process	GO:0033238	3	0.013
molting cycle	GO:0042303	56	0.013
wnt signaling pathway	GO:0016055	98	0.013
negative regulation of cellular biosynthetic process	GO:0031327	277	0.013
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.013
regulation of meiosis	GO:0040020	3	0.013
regulation of locomotion	GO:0040012	42	0.013
regulation of cellular amino acid metabolic process	GO:0006521	0	0.013
protein modification by small protein conjugation	GO:0032446	79	0.013
protein targeting to nucleus	GO:0044744	51	0.013
cellular response to organic substance	GO:0071310	132	0.013
photoreceptor cell differentiation	GO:0046530	170	0.013
cellular protein modification process	GO:0006464	438	0.012
non recombinational repair	GO:0000726	7	0.012
regulation of nucleoside metabolic process	GO:0009118	50	0.012
regulation of intracellular protein transport	GO:0033157	46	0.012
positive regulation of binding	GO:0051099	4	0.012
regionalization	GO:0003002	416	0.012
ion transmembrane transport	GO:0034220	122	0.012
response to nutrient levels	GO:0031667	114	0.012
regulation of intracellular signal transduction	GO:1902531	236	0.012
organonitrogen compound metabolic process	GO:1901564	318	0.012	Human
negative regulation of intracellular signal transduction	GO:1902532	57	0.012
response to virus	GO:0009615	28	0.012
anatomical structure homeostasis	GO:0060249	97	0.012
meiotic cell cycle process	GO:1903046	132	0.011
negative regulation of cell differentiation	GO:0045596	143	0.011
mitotic g2 dna damage checkpoint	GO:0007095	69	0.011
tube formation	GO:0035148	21	0.011
regulation of nucleotide metabolic process	GO:0006140	62	0.011
negative regulation of developmental process	GO:0051093	201	0.011
regulation of mitotic sister chromatid separation	GO:0010965	28	0.011
signal transduction by phosphorylation	GO:0023014	107	0.011
spermatogenesis	GO:0007283	200	0.011
purine containing compound catabolic process	GO:0072523	112	0.011	Human
reproductive system development	GO:0061458	74	0.011
negative regulation of cellular protein metabolic process	GO:0032269	85	0.011
regulation of cysteine type endopeptidase activity	GO:2000116	27	0.011
camera type eye morphogenesis	GO:0048593	2	0.010
cellular homeostasis	GO:0019725	80	0.010
macroautophagy	GO:0016236	42	0.010
negative regulation of cellular component organization	GO:0051129	108	0.010
single organism cellular localization	GO:1902580	180	0.010
organonitrogen compound biosynthetic process	GO:1901566	117	0.010
regulation of cellular response to stress	GO:0080135	89	0.010
peptidyl amino acid modification	GO:0018193	105	0.010
protein phosphorylation	GO:0006468	169	0.010
regulation of wnt signaling pathway	GO:0030111	68	0.010
negative regulation of molecular function	GO:0044092	51	0.010
response to radiation	GO:0009314	155	0.010
meiotic nuclear division	GO:0007126	151	0.010

Rpt1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.044
disease of cellular proliferation	DOID:14566	0.012
organ system cancer	DOID:0050686	0.012
cancer	DOID:162	0.012

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