IMP: Integrative Multi-species Prediction

Drosophila melanogaster

310 known processes

Egfr (Dmel_CG10079)

Epidermal growth factor receptor

(Aliases: dEGFR,l(2)57DEFa,l(2)57Ea,d-egf-r,Torpedo/Egfr,DER,DmHD-33,EGFR,Dmel\CG10079,Egf-r,top/flb,CG10079,l(2)57EFa,Elp,DER/faint little ball,Torpedo/DER,Degfr,Elp-B1,D-Egf,top,torpedo/egfr,EGFr,DER/top,l(2)05351,dEGFR1,EFG-R,Elp-B1RB1,Elp-1,El,egfr,Der,EgfR,dEgfr,DER/torpedo,C-erb,Egf,DER flb,D-EGFR,DEGFR,DER/EGFR,der,top/DER,l(2)09261,c-erbB,EGF-R,EK2-6,flb,HD-33,torpedo/Egfr)

Entrez: 37455
FLYBASE: FBgn0003731
UniProtKB: P04412
UniProtKB: Q8MLW0

Process Predictions
Disease Predictions

Egfr biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
respiratory system development	GO:0060541	213	1.000
open tracheal system development	GO:0007424	204	1.000
ovarian follicle cell migration	GO:0007297	121	1.000
determination of genital disc primordium	GO:0035225	10	1.000
malpighian tubule morphogenesis	GO:0007443	44	1.000
renal system development	GO:0072001	72	1.000
embryonic morphogenesis	GO:0048598	206	1.000
hindgut morphogenesis	GO:0007442	58	1.000
cell migration	GO:0016477	238	1.000
positive regulation of rna metabolic process	GO:0051254	271	1.000	Human Mouse
malpighian tubule development	GO:0072002	64	1.000
digestive system development	GO:0055123	149	1.000
regionalization	GO:0003002	416	1.000
heart development	GO:0007507	82	1.000	Zebrafish Mouse
tube development	GO:0035295	244	1.000
determination of imaginal disc primordium	GO:0007445	11	0.999
ovarian follicle cell development	GO:0030707	248	0.999
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.999	Human Mouse
tissue morphogenesis	GO:0048729	297	0.999
epithelial cell migration	GO:0010631	148	0.999
transcription from rna polymerase ii promoter	GO:0006366	368	0.998	Human
forebrain development	GO:0030900	2	0.998	Mouse Rat
chorion containing eggshell formation	GO:0007304	105	0.998
urogenital system development	GO:0001655	72	0.998
mesenchyme development	GO:0060485	9	0.997	Zebrafish Mouse
immune system process	GO:0002376	347	0.997
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.997
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.997
central nervous system development	GO:0007417	201	0.996	Mouse Rat
appendage morphogenesis	GO:0035107	397	0.996
tube morphogenesis	GO:0035239	191	0.996
brain development	GO:0007420	120	0.996	Mouse Rat
single organism behavior	GO:0044708	391	0.996
regulation of protein metabolic process	GO:0051246	256	0.996	Human Mouse Rat
digestive tract development	GO:0048565	149	0.996
border follicle cell migration	GO:0007298	113	0.996
heart morphogenesis	GO:0003007	32	0.995	Zebrafish
epithelial cell proliferation	GO:0050673	15	0.995
cell motility	GO:0048870	251	0.995
response to organic substance	GO:0010033	284	0.994
negative regulation of multicellular organismal process	GO:0051241	142	0.994
response to oxygen containing compound	GO:1901700	200	0.992
post embryonic appendage morphogenesis	GO:0035120	385	0.992
sensory organ morphogenesis	GO:0090596	260	0.992
cuticle development	GO:0042335	86	0.991
morphogenesis of an epithelium	GO:0002009	276	0.991
epithelial cell differentiation	GO:0030855	322	0.991
positive regulation of macromolecule metabolic process	GO:0010604	405	0.989	Human Mouse Rat
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.989
renal tubule development	GO:0061326	64	0.989
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.989	Human Mouse
ameboidal type cell migration	GO:0001667	151	0.989
bmp signaling pathway	GO:0030509	27	0.988
gliogenesis	GO:0042063	80	0.987	Zebrafish Mouse Rat
cardiovascular system development	GO:0072358	82	0.986	Zebrafish Mouse
response to wounding	GO:0009611	94	0.985
circulatory system development	GO:0072359	82	0.985	Zebrafish Mouse
regulation of tube architecture open tracheal system	GO:0035152	68	0.985
cellular response to chemical stimulus	GO:0070887	199	0.984	Human Mouse Rat
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.984	Human Mouse Rat
nephron development	GO:0072006	3	0.983
positive regulation of transcription dna templated	GO:0045893	266	0.982	Human Mouse
regulation of striated muscle tissue development	GO:0016202	5	0.981	Mouse
axon development	GO:0061564	297	0.981	Zebrafish Mouse Rat
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.981	Human Mouse Rat
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.980	Human
embryonic hindgut morphogenesis	GO:0048619	48	0.979
negative regulation of immune system process	GO:0002683	50	0.979	Mouse
kidney development	GO:0001822	3	0.978
nephron epithelium development	GO:0072009	3	0.978
cellular amine metabolic process	GO:0044106	12	0.978
regulation of muscle organ development	GO:0048634	13	0.977	Mouse
biological adhesion	GO:0022610	138	0.977
columnar cuboidal epithelial cell development	GO:0002066	249	0.977
epithelium migration	GO:0090132	148	0.977
cell surface receptor signaling pathway involved in heart development	GO:0061311	3	0.977
regulation of cellular component movement	GO:0051270	42	0.977	Human Mouse Rat
imaginal disc derived appendage development	GO:0048737	399	0.977
heart induction	GO:0003129	3	0.976
positive regulation of rna biosynthetic process	GO:1902680	266	0.976	Human Mouse
compound eye photoreceptor cell differentiation	GO:0001751	140	0.975
photoreceptor cell fate commitment	GO:0046552	41	0.974
cell projection assembly	GO:0030031	94	0.974
cellular response to growth factor stimulus	GO:0071363	30	0.974	Rat
epithelial cell proliferation involved in malpighian tubule morphogenesis	GO:0061331	11	0.973
regulation of mitotic cell cycle	GO:0007346	190	0.973
positive regulation of cell migration	GO:0030335	2	0.972	Human Rat
taxis	GO:0042330	304	0.970	Mouse
establishment of ommatidial planar polarity	GO:0042067	49	0.969
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.968	Human
positive regulation of multicellular organismal process	GO:0051240	143	0.967	Mouse Rat Worm
kidney epithelium development	GO:0072073	3	0.967
dorsal ventral pattern formation	GO:0009953	133	0.967
imaginal disc derived wing morphogenesis	GO:0007476	337	0.965
organ induction	GO:0001759	3	0.965
chemotaxis	GO:0006935	249	0.964	Mouse
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.959	Human Mouse
appendage development	GO:0048736	401	0.959
stem cell development	GO:0048864	79	0.959
imaginal disc pattern formation	GO:0007447	91	0.956
multicellular organismal reproductive behavior	GO:0033057	110	0.955
renal tubule morphogenesis	GO:0061333	44	0.954
response to external biotic stimulus	GO:0043207	293	0.954
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.952
eye photoreceptor cell fate commitment	GO:0042706	37	0.952
axon guidance	GO:0007411	233	0.950	Mouse
regulation of apoptotic process	GO:0042981	130	0.949
negative regulation of cellular metabolic process	GO:0031324	382	0.949
immune system development	GO:0002520	57	0.949	Mouse
striated muscle cell differentiation	GO:0051146	90	0.948
epithelial cell migration open tracheal system	GO:0007427	32	0.947
digestive tract morphogenesis	GO:0048546	127	0.945
tissue migration	GO:0090130	155	0.942
regulation of proteolysis	GO:0030162	87	0.941
regulation of heart morphogenesis	GO:2000826	3	0.940
negative regulation of cell differentiation	GO:0045596	143	0.940
cell adhesion	GO:0007155	136	0.937
negative regulation of cell development	GO:0010721	62	0.932
regulation of cell differentiation	GO:0045595	302	0.930
cellular response to endogenous stimulus	GO:0071495	80	0.929	Human Mouse Rat
cell maturation	GO:0048469	144	0.928
head development	GO:0060322	135	0.923	Mouse Rat
response to abiotic stimulus	GO:0009628	341	0.923	Human Rat
regulation of cell cycle	GO:0051726	291	0.923
pericardium morphogenesis	GO:0003344	2	0.920
phosphorylation	GO:0016310	294	0.919	Human Mouse Rat
epithelial tube morphogenesis	GO:0060562	88	0.919
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.910
motor neuron axon guidance	GO:0008045	58	0.909	Mouse
blood circulation	GO:0008015	26	0.905	Rat
extracellular structure organization	GO:0043062	46	0.903
compound eye development	GO:0048749	307	0.903
stem cell differentiation	GO:0048863	117	0.900
compound eye photoreceptor fate commitment	GO:0001752	36	0.900
embryonic pattern specification	GO:0009880	174	0.897
regulation of cellular protein metabolic process	GO:0032268	243	0.896	Human Mouse Rat
response to other organism	GO:0051707	293	0.893
imaginal disc derived wing hair organization	GO:0035317	45	0.893
regulation of cellular ketone metabolic process	GO:0010565	3	0.891
eye photoreceptor cell differentiation	GO:0001754	145	0.887
positive regulation of nervous system development	GO:0051962	69	0.886
regulation of cellular response to growth factor stimulus	GO:0090287	13	0.883
regulation of multicellular organismal development	GO:2000026	414	0.883
developmental maturation	GO:0021700	172	0.878
compound eye morphogenesis	GO:0001745	249	0.876
regulation of immune system process	GO:0002682	176	0.876
regulation of cardioblast differentiation	GO:0051890	9	0.874
negative regulation of mitotic cell cycle	GO:0045930	109	0.873
negative regulation of cell cycle	GO:0045786	116	0.872
hindgut development	GO:0061525	58	0.872
cellular response to organic substance	GO:0071310	132	0.856	Human Mouse Rat
regulation of cell migration	GO:0030334	22	0.856	Human Mouse Rat
malpighian tubule tip cell differentiation	GO:0061382	9	0.853
eye antennal disc morphogenesis	GO:0007455	34	0.850
germ line stem cell maintenance	GO:0030718	50	0.849
immune response	GO:0006955	246	0.847
neuron projection guidance	GO:0097485	241	0.845	Mouse
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.844	Human Mouse
regulation of stem cell differentiation	GO:2000736	14	0.842
muscle cell differentiation	GO:0042692	103	0.840
spinal cord dorsal ventral patterning	GO:0021513	1	0.840
embryonic hemopoiesis	GO:0035162	26	0.839
circulatory system process	GO:0003013	37	0.837
morphogenesis of embryonic epithelium	GO:0016331	94	0.836
oocyte construction	GO:0007308	112	0.834
regulation of tube size open tracheal system	GO:0035151	43	0.830
epithelial cell development	GO:0002064	274	0.830
positive regulation of pathway restricted smad protein phosphorylation	GO:0010862	1	0.827
regulation of cell fate specification	GO:0042659	27	0.824
anterior posterior axis specification	GO:0009948	109	0.818
negative regulation of signal transduction	GO:0009968	206	0.813
mesoderm development	GO:0007498	78	0.812
mesenchymal cell differentiation	GO:0048762	1	0.810	Zebrafish Mouse
regulation of cellular amino acid metabolic process	GO:0006521	0	0.806
germarium derived egg chamber formation	GO:0007293	101	0.806
muscle organ development	GO:0007517	127	0.804	Mouse Rat
regulation of cell cycle process	GO:0010564	181	0.802
photoreceptor cell differentiation	GO:0046530	170	0.800
trachea development	GO:0060438	29	0.798
glial cell development	GO:0021782	27	0.792	Zebrafish Rat
positive regulation of cell motility	GO:2000147	3	0.789	Human Rat
establishment of tissue polarity	GO:0007164	87	0.788
aging	GO:0007568	143	0.786
regulation of cell death	GO:0010941	173	0.784
salivary gland morphogenesis	GO:0007435	145	0.784	Mouse
body morphogenesis	GO:0010171	2	0.782
embryonic organ development	GO:0048568	50	0.779	Mouse
regulation of bmp signaling pathway	GO:0030510	23	0.778
oocyte development	GO:0048599	124	0.775
nephron tubule morphogenesis	GO:0072078	3	0.773
pericardium development	GO:0060039	2	0.769
axonogenesis	GO:0007409	290	0.768	Mouse Rat
telencephalon development	GO:0021537	2	0.767	Mouse Rat
neuron fate commitment	GO:0048663	50	0.766
positive regulation of cellular biosynthetic process	GO:0031328	316	0.762	Human Mouse
wing disc morphogenesis	GO:0007472	344	0.760
salivary gland development	GO:0007431	162	0.759
regulation of pathway restricted smad protein phosphorylation	GO:0060393	1	0.755
r3 r4 cell differentiation	GO:0048056	12	0.754
regulation of localization	GO:0032879	275	0.752	Human Mouse Rat
neurological system process	GO:0050877	358	0.751
regulation of nervous system development	GO:0051960	248	0.747
regulation of cell fate commitment	GO:0010453	29	0.747
axis specification	GO:0009798	167	0.746
organelle fission	GO:0048285	340	0.744	Human
heart process	GO:0003015	37	0.740
death	GO:0016265	284	0.739
protein complex assembly	GO:0006461	200	0.738
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.734
dorsal closure	GO:0007391	79	0.734
eye development	GO:0001654	323	0.729
establishment of protein localization	GO:0045184	163	0.728	Human Mouse
cardiocyte differentiation	GO:0035051	29	0.720
negative regulation of gene expression	GO:0010629	387	0.718
response to endogenous stimulus	GO:0009719	119	0.715	Human Mouse Rat
response to alcohol	GO:0097305	95	0.712
negative regulation of response to stimulus	GO:0048585	258	0.710
organonitrogen compound metabolic process	GO:1901564	318	0.706	Mouse
regulation of cellular localization	GO:0060341	136	0.706	Human Mouse
regulation of cellular amine metabolic process	GO:0033238	3	0.704
response to growth factor	GO:0070848	31	0.703	Rat
regulation of organ formation	GO:0003156	3	0.698
negative regulation of cell death	GO:0060548	81	0.695
positive regulation of gene expression	GO:0010628	290	0.692	Human Mouse
negative regulation of developmental process	GO:0051093	201	0.688
negative regulation of cell proliferation	GO:0008285	69	0.676	Human Mouse
eggshell formation	GO:0030703	105	0.669
positive regulation of biosynthetic process	GO:0009891	316	0.663	Human Mouse
camera type eye morphogenesis	GO:0048593	2	0.661
striated muscle tissue development	GO:0014706	27	0.657	Mouse Rat
muscle tissue development	GO:0060537	30	0.653	Mouse Rat
response to radiation	GO:0009314	155	0.653	Human
extracellular matrix assembly	GO:0085029	13	0.652
embryonic heart tube development	GO:0035050	22	0.650
ion transmembrane transport	GO:0034220	122	0.647
small molecule metabolic process	GO:0044281	305	0.646	Mouse
oocyte differentiation	GO:0009994	145	0.645
nuclear division	GO:0000280	332	0.645
regulation of epithelial cell proliferation	GO:0050678	4	0.642	Human Mouse Rat
intracellular signal transduction	GO:0035556	300	0.640	Human Mouse Rat
larval development	GO:0002164	104	0.634	Worm
wound healing	GO:0042060	75	0.631
positive regulation of signaling	GO:0023056	243	0.628	Human Mouse Rat
establishment of localization in cell	GO:0051649	402	0.627	Human Mouse
negative regulation of biosynthetic process	GO:0009890	277	0.626
endodermal cell differentiation	GO:0035987	3	0.626
apoptotic process	GO:0006915	159	0.621
genital disc development	GO:0035215	44	0.614
immune effector process	GO:0002252	98	0.614
negative regulation of apoptotic signaling pathway	GO:2001234	5	0.613
regulation of cell motility	GO:2000145	23	0.612	Human Mouse Rat
protein localization to organelle	GO:0033365	82	0.610	Human Mouse
positive regulation of cell death	GO:0010942	69	0.608
eggshell chorion assembly	GO:0007306	66	0.605
spermatogenesis	GO:0007283	200	0.604
amine metabolic process	GO:0009308	12	0.603
negative regulation of catabolic process	GO:0009895	36	0.594	Human
programmed cell death	GO:0012501	257	0.587
gland morphogenesis	GO:0022612	145	0.583	Mouse Rat
cellular catabolic process	GO:0044248	372	0.577	Mouse
peptide metabolic process	GO:0006518	80	0.577
male gamete generation	GO:0048232	201	0.576
gland development	GO:0048732	191	0.576
eye morphogenesis	GO:0048592	260	0.575
regulation of kinase activity	GO:0043549	53	0.567	Human Rat
exocrine system development	GO:0035272	162	0.566
apoptotic process involved in morphogenesis	GO:0060561	3	0.561
regulation of immune response	GO:0050776	118	0.557
branching morphogenesis of an epithelial tube	GO:0048754	45	0.553
positive regulation of stem cell differentiation	GO:2000738	3	0.551
gastrulation	GO:0007369	70	0.551
regulation of programmed cell death	GO:0043067	152	0.551
imaginal disc derived wing vein specification	GO:0007474	48	0.541
cardioblast cell fate specification	GO:0042685	9	0.539
morphogenesis of a branching structure	GO:0001763	45	0.537
organic substance transport	GO:0071702	257	0.536	Human Mouse Rat
negative regulation of cardiac cell fate specification	GO:2000044	7	0.536
protein phosphorylation	GO:0006468	169	0.535	Human Mouse Rat
regulation of epithelial cell migration	GO:0010632	12	0.532
response to drug	GO:0042493	17	0.527	Rat
hematopoietic or lymphoid organ development	GO:0048534	57	0.527	Mouse
positive regulation of developmental process	GO:0051094	143	0.526	Mouse Worm
neuron recognition	GO:0008038	101	0.525	Zebrafish
r3 r4 cell fate commitment	GO:0007464	10	0.524
negative regulation of cellular protein metabolic process	GO:0032269	85	0.523
stem cell proliferation	GO:0072089	88	0.517
cellular amino acid metabolic process	GO:0006520	61	0.516
wnt signaling pathway	GO:0016055	98	0.511
morphogenesis of a branching epithelium	GO:0061138	45	0.503
connective tissue development	GO:0061448	3	0.501
nephron morphogenesis	GO:0072028	3	0.494
negative regulation of cell migration	GO:0030336	5	0.492
embryonic development via the syncytial blastoderm	GO:0001700	148	0.490
regulation of cell cycle phase transition	GO:1901987	130	0.489
regulation of heart induction	GO:0090381	3	0.488
positive regulation of cell development	GO:0010720	61	0.488
skin development	GO:0043588	65	0.486	Mouse
regulation of neurogenesis	GO:0050767	158	0.485
response to lipid	GO:0033993	38	0.484	Human Rat
hemocyte differentiation	GO:0042386	38	0.480
segmentation	GO:0035282	207	0.477
cellular ketone metabolic process	GO:0042180	24	0.477
positive regulation of neurogenesis	GO:0050769	41	0.472
cell fate commitment involved in formation of primary germ layer	GO:0060795	10	0.472
localization of cell	GO:0051674	257	0.468
formation of primary germ layer	GO:0001704	24	0.464
morphogenesis of an epithelial bud	GO:0060572	3	0.459
mapk cascade	GO:0000165	107	0.459	Human Rat
negative regulation of cellular catabolic process	GO:0031330	34	0.458
mesoderm formation	GO:0001707	21	0.452
carboxylic acid metabolic process	GO:0019752	92	0.451
developmental growth involved in morphogenesis	GO:0060560	65	0.451
positive regulation of muscle organ development	GO:0048636	6	0.451	Mouse
eye antennal disc development	GO:0035214	60	0.449
hemocyte migration	GO:0035099	19	0.448
single organismal cell cell adhesion	GO:0016337	45	0.445
response to biotic stimulus	GO:0009607	294	0.443
cardiac cell fate commitment	GO:0060911	17	0.442
protein maturation	GO:0051604	71	0.439
negative regulation of protein metabolic process	GO:0051248	85	0.438	Human
regulation of protein transport	GO:0051223	57	0.435	Human Mouse
regulation of catalytic activity	GO:0050790	185	0.428	Human Mouse Rat
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.428
maintenance of epithelial integrity open tracheal system	GO:0035160	12	0.425
positive regulation of nucleocytoplasmic transport	GO:0046824	24	0.422	Human Mouse
regulation of innate immune response	GO:0045088	71	0.415
humoral immune response	GO:0006959	117	0.411
heart field specification	GO:0003128	0	0.411
wnt signaling pathway involved in heart development	GO:0003306	3	0.406
negative regulation of apoptotic process	GO:0043066	63	0.405
single organism biosynthetic process	GO:0044711	206	0.404
glial cell differentiation	GO:0010001	35	0.402	Zebrafish Mouse Rat
meiotic nuclear envelope disassembly	GO:0051078	2	0.392
endocrine system development	GO:0035270	5	0.390
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	18	0.385
cellular lipid metabolic process	GO:0044255	83	0.385	Human Rat
haltere disc development	GO:0035216	10	0.382
response to nitrogen compound	GO:1901698	90	0.380	Mouse Rat
branching involved in open tracheal system development	GO:0060446	45	0.376
organic acid metabolic process	GO:0006082	103	0.376
nuclear axial expansion	GO:0035191	3	0.375
protein localization to nucleus	GO:0034504	55	0.375	Human Mouse
renal filtration cell differentiation	GO:0061318	12	0.374
second mitotic wave involved in compound eye morphogenesis	GO:0016330	7	0.371
establishment of protein localization to organelle	GO:0072594	62	0.370	Human Mouse
regulation of neural precursor cell proliferation	GO:2000177	35	0.366
cardioblast differentiation	GO:0010002	20	0.364
kidney morphogenesis	GO:0060993	3	0.356
negative regulation of cell communication	GO:0010648	223	0.355
cell cycle phase transition	GO:0044770	140	0.353
regulation of cell adhesion	GO:0030155	27	0.350	Human
single organism cell adhesion	GO:0098602	47	0.349
segment polarity determination	GO:0007367	25	0.347
wing disc pattern formation	GO:0035222	66	0.342
cellular response to organic cyclic compound	GO:0071407	32	0.342	Human Rat
dendrite regeneration	GO:0031104	2	0.340
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.338
myotube cell development	GO:0014904	3	0.336
peptidyl tyrosine modification	GO:0018212	24	0.335	Human Mouse Rat
regulation of developmental growth	GO:0048638	174	0.334	Mouse
developmental induction	GO:0031128	3	0.334
defense response	GO:0006952	300	0.329	Rat
skeletal muscle fiber development	GO:0048741	3	0.328
synaptic transmission	GO:0007268	288	0.327	Rat
negative regulation of cellular biosynthetic process	GO:0031327	277	0.325
antimicrobial humoral response	GO:0019730	99	0.322
negative regulation of hormone biosynthetic process	GO:0032353	1	0.322
labial disc development	GO:0035217	4	0.322
negative regulation of cardioblast differentiation	GO:0051892	7	0.321
instar larval development	GO:0002168	55	0.319
defense response to gram negative bacterium	GO:0050829	94	0.318
regulation of molecular function	GO:0065009	217	0.317	Human Mouse Rat
regulation of defense response	GO:0031347	102	0.316	Rat
dorsal appendage formation	GO:0046843	47	0.313
somatic stem cell maintenance	GO:0035019	14	0.311
regulation of secretion by cell	GO:1903530	39	0.311
striated muscle cell development	GO:0055002	50	0.310
regulation of cardioblast cell fate specification	GO:0042686	8	0.309
germ cell migration	GO:0008354	43	0.308
cell fate specification	GO:0001708	71	0.306
positive regulation of cellular component organization	GO:0051130	156	0.306
genital disc pattern formation	GO:0035221	8	0.304
retina development in camera type eye	GO:0060041	4	0.303
regulation of transferase activity	GO:0051338	58	0.301	Human Rat
cell cell adhesion via plasma membrane adhesion molecules	GO:0098742	26	0.297
developmental programmed cell death	GO:0010623	138	0.296
limb development	GO:0060173	1	0.293
positive regulation of growth	GO:0045927	75	0.291	Human Mouse
meiotic cell cycle	GO:0051321	171	0.288
positive regulation of transcription from rna polymerase i promoter	GO:0045943	3	0.286	Human
regulation of anatomical structure morphogenesis	GO:0022603	242	0.286
epithelial cell proliferation involved in renal tubule morphogenesis	GO:2001013	11	0.286
positive regulation of response to stimulus	GO:0048584	323	0.282
notch signaling pathway	GO:0007219	120	0.280
negative regulation of neurogenesis	GO:0050768	53	0.280
regulation of protein phosphorylation	GO:0001932	64	0.276	Human Mouse Rat
nephron tubule development	GO:0072080	3	0.275
protein modification process	GO:0036211	438	0.275	Human Mouse Rat
oxoacid metabolic process	GO:0043436	103	0.273
mesodermal cell fate specification	GO:0007501	2	0.271
regulation of immune effector process	GO:0002697	52	0.270
skeletal muscle tissue development	GO:0007519	13	0.269	Rat
oocyte morphogenesis	GO:0048601	3	0.269
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.268
determination of dorsal ventral asymmetry	GO:0048262	3	0.266
establishment of planar polarity	GO:0001736	87	0.265
negative regulation of mitotic anaphase promoting complex activity	GO:0060564	2	0.265
negative regulation of cell fate specification	GO:0009996	15	0.263
protein localization	GO:0008104	284	0.256	Human Mouse
extracellular matrix organization	GO:0030198	32	0.252
regulation of proteasomal protein catabolic process	GO:0061136	39	0.249
positive regulation of apoptotic process	GO:0043065	47	0.248
dorsal ventral pattern formation imaginal disc	GO:0007450	51	0.248
regulation of cell division	GO:0051302	72	0.248
cellular response to dna damage stimulus	GO:0006974	223	0.247	Human
stem cell maintenance	GO:0019827	67	0.247
anterior posterior pattern specification imaginal disc	GO:0007448	16	0.247
regulation of planar cell polarity pathway involved in axis elongation	GO:2000040	2	0.245
genital disc anterior posterior pattern formation	GO:0035224	8	0.243
carbohydrate derivative metabolic process	GO:1901135	217	0.241	Mouse
organic hydroxy compound metabolic process	GO:1901615	83	0.240
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.240
apical junction assembly	GO:0043297	32	0.240
negative regulation of cellular component organization	GO:0051129	108	0.239
cellular protein modification process	GO:0006464	438	0.239	Human Mouse Rat
larval lymph gland hemopoiesis	GO:0035167	17	0.238
macromolecular complex assembly	GO:0065003	256	0.237
oocyte axis specification	GO:0007309	108	0.236
lateral inhibition	GO:0046331	206	0.232
regulation of system process	GO:0044057	36	0.229	Rat
protein complex biogenesis	GO:0070271	201	0.228
regulation of cell proliferation involved in compound eye morphogenesis	GO:2000495	2	0.226
limb morphogenesis	GO:0035108	1	0.225
hematopoietic progenitor cell differentiation	GO:0002244	1	0.223
cardioblast cell fate commitment	GO:0042684	14	0.223
protein processing	GO:0016485	68	0.222
positive regulation of phosphorylation	GO:0042327	87	0.222	Human Mouse Rat
regulation of apoptotic signaling pathway	GO:2001233	10	0.221
regulation of reproductive process	GO:2000241	54	0.218
protein import	GO:0017038	55	0.214	Human Mouse
positive regulation of programmed cell death	GO:0043068	62	0.213
enteroendocrine cell differentiation	GO:0035883	1	0.213
multi organism behavior	GO:0051705	175	0.213
protein transport	GO:0015031	155	0.213	Human Mouse
outflow tract morphogenesis	GO:0003151	4	0.211
learning or memory	GO:0007611	141	0.211
positive regulation of cell proliferation	GO:0008284	47	0.206
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.205
negative regulation of wnt signaling pathway	GO:0030178	28	0.204
reproductive structure development	GO:0048608	74	0.202
regulation of neuron differentiation	GO:0045664	103	0.202
endodermal cell fate commitment	GO:0001711	3	0.202
negative regulation of rna biosynthetic process	GO:1902679	240	0.200
cell type specific apoptotic process	GO:0097285	38	0.200	Human Mouse Rat
regulation of glial cell differentiation	GO:0045685	1	0.199
response to decreased oxygen levels	GO:0036293	58	0.199
positive regulation of cellular protein metabolic process	GO:0032270	118	0.198	Human Mouse Rat
circadian rhythm	GO:0007623	105	0.197	Rat
regulation of protein modification process	GO:0031399	112	0.194	Human Mouse Rat
maternal determination of dorsal ventral axis ovarian follicular epithelium germ line encoded	GO:0008070	2	0.191
regulation of establishment of protein localization	GO:0070201	61	0.191	Human Mouse
camera type eye development	GO:0043010	4	0.190
response to hormone	GO:0009725	45	0.188	Human Rat
defense response to fungus	GO:0050832	48	0.187
response to organic cyclic compound	GO:0014070	89	0.187	Human Rat
cardiac muscle tissue development	GO:0048738	9	0.187	Mouse
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.187
positive regulation of cell differentiation	GO:0045597	64	0.185
mesenchymal cell development	GO:0014031	1	0.184	Zebrafish Mouse
regulation of cell proliferation	GO:0042127	163	0.182
lipid localization	GO:0010876	54	0.181
positive regulation of immune system process	GO:0002684	68	0.180
reproductive behavior	GO:0019098	122	0.179
response to transforming growth factor beta	GO:0071559	18	0.178
signal transduction by phosphorylation	GO:0023014	107	0.178	Human Rat
juvenile hormone mediated signaling pathway	GO:0035626	3	0.175
cytokinesis	GO:0000910	90	0.174
regulation of organ morphogenesis	GO:2000027	78	0.174
response to virus	GO:0009615	28	0.173
epidermis development	GO:0008544	65	0.171	Mouse
regulation of muscle cell differentiation	GO:0051147	8	0.171
negative regulation of proteolysis	GO:0045861	31	0.171
negative regulation of canonical wnt signaling pathway	GO:0090090	6	0.170
dorsal ventral axis specification	GO:0009950	66	0.170
proteolysis	GO:0006508	192	0.169
positive regulation of cell communication	GO:0010647	250	0.169	Human Mouse Rat
negative regulation of nervous system development	GO:0051961	92	0.169
response to hypoxia	GO:0001666	53	0.169
epithelial cell type specification open tracheal system	GO:0035153	11	0.169
regulation of anatomical structure size	GO:0090066	163	0.168	Rat

Egfr disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability	Func Analog Org
bone development disease	DOID:0080006	0.869
bone disease	DOID:0080001	0.869
disease of anatomical entity	DOID:7	0.869	Human
musculoskeletal system disease	DOID:17	0.869
connective tissue disease	DOID:65	0.869
cardiovascular system disease	DOID:1287	0.295

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network