IMP: Integrative Multi-species Prediction

Drosophila melanogaster

0 known processes

Tina-1 (Dmel_CG2803)

Troponin C-akin-1

(Aliases: Dmel\CG2803,CG2803,BEST:GM14784)

Entrez: 37989
FLYBASE: FBgn0035083
UniProtKB: Q9W0Y1
UniProtKB: Q2PE12

Process Predictions
Disease Predictions

Tina-1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
negative regulation of response to stimulus	GO:0048585	258	0.129
negative regulation of cell communication	GO:0010648	223	0.095
small molecule metabolic process	GO:0044281	305	0.074
negative regulation of signal transduction	GO:0009968	206	0.065
organonitrogen compound metabolic process	GO:1901564	318	0.060
negative regulation of signaling	GO:0023057	219	0.056
cellular amino acid metabolic process	GO:0006520	61	0.054
single organism catabolic process	GO:0044712	228	0.053
establishment of localization in cell	GO:0051649	402	0.050
growth	GO:0040007	359	0.048
immune response regulating signaling pathway	GO:0002764	2	0.047
immune system process	GO:0002376	347	0.046
oxoacid metabolic process	GO:0043436	103	0.045
endocytosis	GO:0006897	310	0.042
body morphogenesis	GO:0010171	2	0.042
sterol homeostasis	GO:0055092	4	0.042
cellular protein modification process	GO:0006464	438	0.041
appendage development	GO:0048736	401	0.039
sulfur compound metabolic process	GO:0006790	59	0.039
regulation of immune system process	GO:0002682	176	0.038
negative regulation of biosynthetic process	GO:0009890	277	0.036
wing disc morphogenesis	GO:0007472	344	0.036
death	GO:0016265	284	0.035
vesicle mediated transport	GO:0016192	381	0.035
response to oxygen containing compound	GO:1901700	200	0.033
immune response activating signal transduction	GO:0002757	2	0.032
organic acid metabolic process	GO:0006082	103	0.031
cellular catabolic process	GO:0044248	372	0.030
regulation of immune response	GO:0050776	118	0.030
embryo development ending in birth or egg hatching	GO:0009792	152	0.030
carbohydrate derivative metabolic process	GO:1901135	217	0.029
post embryonic appendage morphogenesis	GO:0035120	385	0.027
carboxylic acid metabolic process	GO:0019752	92	0.026
regulation of response to stress	GO:0080134	200	0.026
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.026
regulation of multicellular organismal development	GO:2000026	414	0.025
imaginal disc derived wing morphogenesis	GO:0007476	337	0.025
regulation of programmed cell death	GO:0043067	152	0.024
taxis	GO:0042330	304	0.024
response to lipopolysaccharide	GO:0032496	4	0.024
regulation of notch signaling pathway	GO:0008593	100	0.024
tissue morphogenesis	GO:0048729	297	0.024
renal system development	GO:0072001	72	0.023
organelle assembly	GO:0070925	198	0.023
thioester metabolic process	GO:0035383	3	0.023
negative regulation of transcription dna templated	GO:0045892	237	0.023
organic substance catabolic process	GO:1901575	308	0.023
innate immune response	GO:0045087	144	0.023
response to endogenous stimulus	GO:0009719	119	0.022
immune response	GO:0006955	246	0.022
head development	GO:0060322	135	0.022
gland development	GO:0048732	191	0.021
programmed cell death	GO:0012501	257	0.021
response to organic substance	GO:0010033	284	0.021
notch signaling pathway	GO:0007219	120	0.021
kidney development	GO:0001822	3	0.021
cellular response to external stimulus	GO:0071496	66	0.021
actin filament based process	GO:0030029	220	0.020
ameboidal type cell migration	GO:0001667	151	0.020
protein modification process	GO:0036211	438	0.020
tube development	GO:0035295	244	0.020
negative regulation of cellular metabolic process	GO:0031324	382	0.020
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.020
organic substance transport	GO:0071702	257	0.019
single organism cellular localization	GO:1902580	180	0.019
epithelial cell differentiation	GO:0030855	322	0.019
regionalization	GO:0003002	416	0.019
cellular response to chemical stimulus	GO:0070887	199	0.019
response to hypoxia	GO:0001666	53	0.019
single organism intracellular transport	GO:1902582	207	0.018
cell proliferation	GO:0008283	299	0.018
nucleobase containing compound catabolic process	GO:0034655	165	0.018
phosphorylation	GO:0016310	294	0.018
cellular response to oxygen containing compound	GO:1901701	79	0.018
homeostatic process	GO:0042592	199	0.018
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.018
response to external biotic stimulus	GO:0043207	293	0.018
brain development	GO:0007420	120	0.018
organophosphate metabolic process	GO:0019637	195	0.018
cellular response to starvation	GO:0009267	61	0.018
glycerolipid catabolic process	GO:0046503	3	0.018
retina development in camera type eye	GO:0060041	4	0.018
acyl coa metabolic process	GO:0006637	3	0.017
apoptotic process	GO:0006915	159	0.017
catabolic process	GO:0009056	409	0.017
epithelial cell development	GO:0002064	274	0.017
macromolecular complex assembly	GO:0065003	256	0.017
tube morphogenesis	GO:0035239	191	0.017
regulation of cell death	GO:0010941	173	0.017
morphogenesis of an epithelium	GO:0002009	276	0.017
response to other organism	GO:0051707	293	0.017
nuclear transport	GO:0051169	72	0.016
response to abiotic stimulus	GO:0009628	341	0.016
positive regulation of response to stimulus	GO:0048584	323	0.016
jnk cascade	GO:0007254	50	0.016
cell death	GO:0008219	279	0.016
circulatory system development	GO:0072359	82	0.016
mitotic nuclear division	GO:0007067	213	0.016
chromosome organization	GO:0051276	360	0.015
cytoplasmic transport	GO:0016482	130	0.015
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.015
kidney epithelium development	GO:0072073	3	0.015
regulation of cellular response to stress	GO:0080135	89	0.015
positive regulation of cell communication	GO:0010647	250	0.015
intracellular transport	GO:0046907	228	0.015
cellular response to organic substance	GO:0071310	132	0.015
regulation of transport	GO:0051049	181	0.015
negative regulation of cell differentiation	GO:0045596	143	0.015
phagocytosis	GO:0006909	215	0.015
defense response	GO:0006952	300	0.014
cellular macromolecule localization	GO:0070727	220	0.014
protein complex biogenesis	GO:0070271	201	0.014
positive regulation of immune system process	GO:0002684	68	0.014
negative regulation of cellular component organization	GO:0051129	108	0.014
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.014
organonitrogen compound catabolic process	GO:1901565	128	0.014
stem cell differentiation	GO:0048863	117	0.014
response to biotic stimulus	GO:0009607	294	0.014
imaginal disc derived appendage development	GO:0048737	399	0.014
regulation of growth	GO:0040008	233	0.013
negative regulation of cellular biosynthetic process	GO:0031327	277	0.013
cellular nitrogen compound catabolic process	GO:0044270	165	0.013
nucleoside phosphate metabolic process	GO:0006753	162	0.013
positive regulation of signaling	GO:0023056	243	0.013
regulation of anatomical structure morphogenesis	GO:0022603	242	0.013
response to starvation	GO:0042594	97	0.013
single organism biosynthetic process	GO:0044711	206	0.013
transcription from rna polymerase ii promoter	GO:0006366	368	0.013
cation transport	GO:0006812	110	0.013
neurological system process	GO:0050877	358	0.013
oocyte development	GO:0048599	124	0.013
response to hexose	GO:0009746	3	0.013
positive regulation of cell motility	GO:2000147	3	0.012
secretion	GO:0046903	109	0.012
regulation of cell development	GO:0060284	215	0.012
appendage morphogenesis	GO:0035107	397	0.012
camera type eye development	GO:0043010	4	0.012
cell growth	GO:0016049	108	0.012
response to alcohol	GO:0097305	95	0.012
negative regulation of rna metabolic process	GO:0051253	251	0.012
regulation of mrna processing	GO:0050684	71	0.012
regulation of localization	GO:0032879	275	0.012
central nervous system development	GO:0007417	201	0.012
translation	GO:0006412	69	0.012
regulation of cell projection organization	GO:0031344	92	0.012
nucleotide catabolic process	GO:0009166	109	0.012
regulation of cellular protein metabolic process	GO:0032268	243	0.012
nucleobase containing small molecule metabolic process	GO:0055086	174	0.012
ribose phosphate metabolic process	GO:0019693	145	0.012
nephron epithelium development	GO:0072009	3	0.012
purine nucleoside metabolic process	GO:0042278	127	0.012
regulation of mrna metabolic process	GO:1903311	72	0.012
regulation of cell substrate adhesion	GO:0010810	2	0.011
regulation of rna splicing	GO:0043484	69	0.011
purine ribonucleoside metabolic process	GO:0046128	127	0.011
organic cyclic compound catabolic process	GO:1901361	168	0.011
eye development	GO:0001654	323	0.011
cellular component disassembly	GO:0022411	46	0.011
response to wounding	GO:0009611	94	0.011
positive regulation of macromolecule metabolic process	GO:0010604	405	0.011
cell aging	GO:0007569	2	0.011
positive regulation of transcription dna templated	GO:0045893	266	0.011
regulation of cellular ketone metabolic process	GO:0010565	3	0.011
intracellular signal transduction	GO:0035556	300	0.011
response to copper ion	GO:0046688	4	0.011
cellular amine metabolic process	GO:0044106	12	0.011
cellular protein localization	GO:0034613	160	0.011
regulation of innate immune response	GO:0045088	71	0.011
stress activated protein kinase signaling cascade	GO:0031098	55	0.011
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.011
carbohydrate derivative biosynthetic process	GO:1901137	85	0.011
chromatin organization	GO:0006325	207	0.011
nucleocytoplasmic transport	GO:0006913	72	0.011
negative regulation of developmental process	GO:0051093	201	0.010
negative regulation of multicellular organismal process	GO:0051241	142	0.010
pattern recognition receptor signaling pathway	GO:0002221	2	0.010
chromosome segregation	GO:0007059	157	0.010
regulation of mapk cascade	GO:0043408	92	0.010
digestive system development	GO:0055123	149	0.010
endomembrane system organization	GO:0010256	119	0.010
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.010
sister chromatid segregation	GO:0000819	92	0.010
response to temperature stimulus	GO:0009266	106	0.010
regulation of phosphorylation	GO:0042325	147	0.010
spindle organization	GO:0007051	253	0.010
positive regulation of immune response	GO:0050778	63	0.010
regulation of cellular amine metabolic process	GO:0033238	3	0.010
mrna metabolic process	GO:0016071	124	0.010

Tina-1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.032
disease of metabolism	DOID:0014667	0.024
inherited metabolic disorder	DOID:655	0.019
urinary system disease	DOID:18	0.017
kidney disease	DOID:557	0.017
renal tubular transport disease	DOID:447	0.017
glucose metabolism disease	DOID:4194	0.015
carbohydrate metabolism disease	DOID:0050013	0.015
acquired metabolic disease	DOID:0060158	0.015
nervous system disease	DOID:863	0.011

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