Drosophila melanogaster

56 known processes

fray (Dmel_CG7693)

frayed

(Aliases: STE20-like/SPAK,l(3)07551,dSTRAD,lag,Dmel\CG7693,4624,CG7693)

fray biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
negative regulation of signalingGO:00230572190.432
embryonic development via the syncytial blastodermGO:00017001480.296
negative regulation of cell communicationGO:00106482230.197
imaginal disc derived appendage morphogenesisGO:00351143950.169
organonitrogen compound metabolic processGO:19015643180.165
embryonic morphogenesisGO:00485982060.160
tube morphogenesisGO:00352391910.148
Worm
eye morphogenesisGO:00485922600.141
imaginal disc derived appendage developmentGO:00487373990.128
eye developmentGO:00016543230.127
regionalizationGO:00030024160.119
cellular protein modification processGO:00064644380.114
Human Mouse Rat Worm
organic acid metabolic processGO:00060821030.111
embryo development ending in birth or egg hatchingGO:00097921520.106
immune system processGO:00023763470.090
asymmetric stem cell divisionGO:0098722490.088
carboxylic acid metabolic processGO:0019752920.087
compound eye developmentGO:00487493070.081
peptidyl threonine phosphorylationGO:001810720.078
Human Mouse Worm
small molecule metabolic processGO:00442813050.078
sevenless signaling pathwayGO:004550040.075
digestive tract morphogenesisGO:00485461270.071
stem cell divisionGO:0017145690.070
neuroblast divisionGO:0055057350.068
imaginal disc derived wing morphogenesisGO:00074763370.067
ras protein signal transductionGO:0007265880.067
protein modification processGO:00362114380.064
Human Mouse Rat Worm
tissue morphogenesisGO:00487292970.064
Worm
memoryGO:0007613940.062
regulation of phosphate metabolic processGO:00192202100.062
Mouse
regulation of catalytic activityGO:00507901850.062
hemopoiesisGO:0030097460.061
positive regulation of catalytic activityGO:00430851180.059
digestive tract developmentGO:00485651490.057
establishment of localization in cellGO:00516494020.057
single organism behaviorGO:00447083910.056
appendage morphogenesisGO:00351073970.055
wing disc morphogenesisGO:00074723440.054
anatomical structure homeostasisGO:0060249970.054
developmental growthGO:00485892800.054
positive regulation of nitrogen compound metabolic processGO:00511733540.053
negative regulation of signal transductionGO:00099682060.052
positive regulation of molecular functionGO:00440931360.051
regulation of mitotic cell cycle phase transitionGO:19019901300.051
post embryonic appendage morphogenesisGO:00351203850.051
endocytosisGO:00068973100.050
short term memoryGO:0007614190.049
neurological system processGO:00508773580.049
synapse assemblyGO:00074161430.049
localization of cellGO:00516742570.049
positive regulation of gtpase activityGO:0043547430.047
regulation of cell cycleGO:00517262910.047
programmed cell deathGO:00125012570.047
regulation of cellular catabolic processGO:00313291570.047
deathGO:00162652840.046
small gtpase mediated signal transductionGO:0007264880.046
cell deathGO:00082192790.044
segmentationGO:00352822070.044
guanosine containing compound metabolic processGO:1901068740.043
oxoacid metabolic processGO:00434361030.043
regulation of ras protein signal transductionGO:0046578930.042
negative regulation of cellular protein metabolic processGO:0032269850.042
Mouse
regulation of small gtpase mediated signal transductionGO:0051056930.042
cell cell signaling involved in cell fate commitmentGO:00451682100.042
positive regulation of nucleotide catabolic processGO:0030813460.042
homeostatic processGO:00425921990.041
Mouse
regulation of nucleotide metabolic processGO:0006140620.040
tube developmentGO:00352952440.040
Worm
vesicle organizationGO:0016050440.040
apoptotic processGO:00069151590.040
negative regulation of response to stimulusGO:00485852580.039
response to abiotic stimulusGO:00096283410.039
Mouse
regulation of phosphorus metabolic processGO:00511742100.038
Mouse
cellular ketone metabolic processGO:0042180240.038
regulation of intracellular signal transductionGO:19025312360.037
intracellular transportGO:00469072280.037
sensory organ morphogenesisGO:00905962600.037
regulation of cellular protein metabolic processGO:00322682430.036
Mouse
compound eye morphogenesisGO:00017452490.036
positive regulation of macromolecule metabolic processGO:00106044050.036
appendage developmentGO:00487364010.036
cell motilityGO:00488702510.035
proteasomal protein catabolic processGO:0010498590.035
histone modificationGO:00165701060.035
gastrulation with mouth forming firstGO:0001703360.035
regulation of nucleoside metabolic processGO:0009118500.035
learning or memoryGO:00076111410.034
catabolic processGO:00090564090.034
protein phosphorylationGO:00064681690.034
Human Mouse Rat Worm
rubidium ion transportGO:003582610.034
Human Mouse
actin cytoskeleton organizationGO:00300362060.033
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.033
positive regulation of transportGO:0051050920.033
Rat
positive regulation of hydrolase activityGO:0051345780.033
regulation of cell cycle phase transitionGO:19019871300.033
gland developmentGO:00487321910.033
regulation of hydrolase activityGO:0051336970.033
purine nucleoside catabolic processGO:00061521120.033
gastrulationGO:0007369700.033
cellular amine metabolic processGO:0044106120.032
somatic stem cell divisionGO:0048103370.032
actin filament based processGO:00300292200.031
cell growthGO:00160491080.031
leg disc developmentGO:0035218920.031
myotube cell developmentGO:001490430.030
eye photoreceptor cell differentiationGO:00017541450.030
regulation of apoptotic processGO:00429811300.030
protein transportGO:00150311550.029
somatic muscle developmentGO:0007525660.029
phosphorylationGO:00163102940.028
Human Mouse Rat Worm
positive regulation of response to stimulusGO:00485843230.028
regulation of cellular amine metabolic processGO:003323830.028
activation of cysteine type endopeptidase activityGO:0097202170.028
regulation of nervous system developmentGO:00519602480.028
positive regulation of nucleoside metabolic processGO:0045979470.028
organelle assemblyGO:00709251980.027
positive regulation of nucleic acid templated transcriptionGO:19035082660.027
negative regulation of protein metabolic processGO:0051248850.026
Mouse
cellular protein localizationGO:00346131600.026
imaginal disc derived wing vein specificationGO:0007474480.026
regulation of growthGO:00400082330.026
cellular amino acid metabolic processGO:0006520610.026
macromolecule catabolic processGO:00090571610.026
imaginal disc derived leg morphogenesisGO:0007480800.026
immune system developmentGO:0002520570.026
regulation of protein modification processGO:00313991120.026
Mouse
single organism cellular localizationGO:19025801800.025
camera type eye developmentGO:004301040.025
regulation of purine nucleotide metabolic processGO:1900542620.024
nucleoside phosphate metabolic processGO:00067531620.024
regulation of gtp catabolic processGO:0033124440.024
gland morphogenesisGO:00226121450.024
regulation of mitotic cell cycleGO:00073461900.024
regulation of vesicle mediated transportGO:0060627590.024
negative regulation of nitrogen compound metabolic processGO:00511722650.023
vesicle mediated transportGO:00161923810.023
establishment or maintenance of cell polarityGO:00071631670.023
regulation of phosphorylationGO:00423251470.023
Mouse
positive regulation of signalingGO:00230562430.023
mitotic spindle organizationGO:00070522200.023
enzyme linked receptor protein signaling pathwayGO:00071671790.023
mitotic dna integrity checkpointGO:0044774750.023
cellular response to dna damage stimulusGO:00069742230.023
regulation of transportGO:00510491810.022
Human Mouse Rat
negative regulation of erk1 and erk2 cascadeGO:007037330.022
negative regulation of cell cycle phase transitionGO:19019881030.022
regulation of gtpase activityGO:0043087440.022
gastrulation involving germ band extensionGO:0010004360.022
regulation of protein phosphorylationGO:0001932640.022
Mouse
cytokinesisGO:0000910900.022
regulation of organ morphogenesisGO:2000027780.022
response to radiationGO:00093141550.022
intracellular signal transductionGO:00355563000.022
Human Mouse
purine nucleoside triphosphate metabolic processGO:00091441190.022
organic substance catabolic processGO:19015753080.022
negative regulation of cellular metabolic processGO:00313243820.022
Mouse
proteolysis involved in cellular protein catabolic processGO:0051603830.022
regulation of synapse structure and activityGO:00508031280.022
cognitionGO:00508901410.021
periodic partitioningGO:0007365290.021
asymmetric neuroblast divisionGO:0055059330.021
positive regulation of purine nucleotide catabolic processGO:0033123460.021
photoreceptor cell differentiationGO:00465301700.021
cellular catabolic processGO:00442483720.021
single organism membrane fusionGO:0044801420.020
notch signaling pathwayGO:00072191200.020
positive regulation of phosphate metabolic processGO:00459371390.020
wnt signaling pathwayGO:0016055980.020
negative regulation of apoptotic processGO:0043066630.020
eye photoreceptor cell developmentGO:0042462810.020
dephosphorylationGO:0016311510.020
morphogenesis of an epitheliumGO:00020092760.020
Worm
positive regulation of cell communicationGO:00106472500.020
positive regulation of cellular catabolic processGO:0031331950.020
regulation of developmental growthGO:00486381740.020
neuronal stem cell divisionGO:0036445350.020
mitotic cell cycle checkpointGO:0007093880.020
mitotic nuclear divisionGO:00070672130.019
response to endogenous stimulusGO:00097191190.019
epithelial cell differentiationGO:00308553220.019
lateral inhibitionGO:00463312060.019
germ line stem cell niche homeostasisGO:006025050.019
regulation of nucleotide catabolic processGO:0030811480.019
response to organic substanceGO:00100332840.019
purine nucleotide metabolic processGO:00061631460.019
negative regulation of mitotic cell cycle phase transitionGO:19019911030.019
regulation of r7 cell differentiationGO:0045676150.019
purine nucleoside metabolic processGO:00422781270.019
dna damage checkpointGO:0000077780.019
regulation of cellular component biogenesisGO:00440872010.019
regulation of cellular ketone metabolic processGO:001056530.019
negative regulation of programmed cell deathGO:0043069720.018
establishment of planar polarityGO:0001736870.018
cytoplasmic transportGO:00164821300.018
exocrine system developmentGO:00352721620.018
hematopoietic or lymphoid organ developmentGO:0048534570.018
regulation of actin polymerization or depolymerizationGO:0008064270.018
regulation of programmed cell deathGO:00430671520.018
positive regulation of rna metabolic processGO:00512542710.018
cell migrationGO:00164772380.018
protein processingGO:0016485680.018
negative regulation of intracellular signal transductionGO:1902532570.018
positive regulation of developmental processGO:00510941430.018
positive regulation of peptidase activityGO:0010952290.017
erk1 and erk2 cascadeGO:0070371390.017
regulation of epidermal growth factor receptor signaling pathwayGO:0042058420.017
nuclear divisionGO:00002803320.017
imaginal disc derived wing vein morphogenesisGO:0008586440.017
positive regulation of purine nucleotide metabolic processGO:1900544550.017
protein catabolic processGO:00301631010.017
blastoderm segmentationGO:00073501590.017
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280230.017
regulation of immune system processGO:00026821760.017
positive regulation of cellular amino acid metabolic processGO:004576400.017
peptidyl amino acid modificationGO:00181931050.017
Human Mouse Worm
regulation of cellular amino acid metabolic processGO:000652100.016
peptidyl threonine modificationGO:001821030.016
Human Mouse Worm
carbohydrate derivative metabolic processGO:19011352170.016
adult somatic muscle developmentGO:0007527140.016
urogenital system developmentGO:0001655720.016
negative regulation of protein tyrosine kinase activityGO:006109950.016
phagocytosisGO:00069092150.016
purine ribonucleoside triphosphate metabolic processGO:00092051190.016
digestive system developmentGO:00551231490.016
negative regulation of catabolic processGO:0009895360.016
regulation of cell morphogenesis involved in differentiationGO:0010769610.016
single organism intracellular transportGO:19025822070.016
compound eye photoreceptor cell differentiationGO:00017511400.016
cell fate determinationGO:0001709910.016
developmental growth involved in morphogenesisGO:0060560650.016
microtubule based transportGO:0010970420.016
positive regulation of developmental growthGO:0048639620.016
organic substance transportGO:00717022570.015
positive regulation of synaptic growth at neuromuscular junctionGO:0045887260.015
positive regulation of nucleobase containing compound metabolic processGO:00459353320.015
organelle fissionGO:00482853400.015
positive regulation of photoreceptor cell differentiationGO:0046534120.015
vesicle fusionGO:0006906190.015
muscle organ developmentGO:00075171270.015
regulation of cellular protein catabolic processGO:1903362440.015
positive regulation of rna biosynthetic processGO:19026802660.015
negative regulation of photoreceptor cell differentiationGO:004653380.015
regulation of proteolysisGO:0030162870.015
erbb signaling pathwayGO:0038127580.015
purine ribonucleoside triphosphate catabolic processGO:00092071080.015
negative regulation of smoothened signaling pathwayGO:0045879160.015
compound eye photoreceptor developmentGO:0042051780.015
regulation of lipid transportGO:003236830.015
purine ribonucleotide catabolic processGO:00091541090.015
centriole replicationGO:0007099240.015
regulation of cell cycle processGO:00105641810.015
regulation of anatomical structure morphogenesisGO:00226032420.015
organonitrogen compound catabolic processGO:19015651280.015
purine containing compound catabolic processGO:00725231120.014
positive regulation of cellular protein metabolic processGO:00322701180.014
growthGO:00400073590.014
regulation of multicellular organism growthGO:0040014400.014
positive regulation of signal transductionGO:00099672230.014
axon guidanceGO:00074112330.014
organic cyclic compound catabolic processGO:19013611680.014
purine ribonucleotide metabolic processGO:00091501450.014
body morphogenesisGO:001017120.014
regulation of cytoskeleton organizationGO:0051493890.014
cell divisionGO:00513012480.014
negative regulation of transferase activityGO:0051348180.014
positive regulation of transcription dna templatedGO:00458932660.014
negative regulation of epithelial cell migrationGO:001063310.014
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.014
cell cell junction assemblyGO:0007043380.014
head involutionGO:0008258350.014
dorsal ventral pattern formationGO:00099531330.014
regulation of molecular functionGO:00650092170.014
Human Mouse
regulation of photoreceptor cell differentiationGO:0046532340.014
inorganic cation transmembrane transportGO:0098662610.014
Human Mouse
head developmentGO:00603221350.014
positive regulation of cellular biosynthetic processGO:00313283160.014
phototransductionGO:0007602520.014
nucleocytoplasmic transportGO:0006913720.014
regulation of embryonic developmentGO:0045995680.014
single organism biosynthetic processGO:00447112060.013
tissue deathGO:00162711020.013
cellular response to growth factor stimulusGO:0071363300.013
taxisGO:00423303040.013
chromosome organizationGO:00512763600.013
regulation of notch signaling pathwayGO:00085931000.013
protein maturationGO:0051604710.013
negative regulation of erbb signaling pathwayGO:1901185290.013
smad protein import into nucleusGO:0007184110.013
single organismal cell cell adhesionGO:0016337450.013
ribonucleoside triphosphate metabolic processGO:00091991190.013
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161540.013
cytoskeleton dependent cytokinesisGO:0061640810.013
positive regulation of cell cycle g2 m phase transitionGO:190275120.013
positive regulation of gtp catabolic processGO:0033126430.013
negative regulation of phosphorylationGO:0042326350.013
Mouse
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434370.013
nucleoside triphosphate metabolic processGO:00091411200.013
developmental cell growthGO:0048588520.013
ubiquitin dependent protein catabolic processGO:0006511780.013
positive regulation of macromolecule biosynthetic processGO:00105572830.013
nucleoside metabolic processGO:00091161270.013
microtubule organizing center organizationGO:00310231680.013
water homeostasisGO:003010430.013
negative regulation of r7 cell differentiationGO:004567720.013
convergent extensionGO:006002620.012
embryonic pattern specificationGO:00098801740.012
compound eye retinal cell programmed cell deathGO:0046667230.012
regulation of catabolic processGO:00098941700.012
transcription from rna polymerase ii promoterGO:00063663680.012
mitotic g2 m transition checkpointGO:0044818700.012
cellular macromolecule localizationGO:00707272200.012
reproductive behaviorGO:00190981220.012
salivary gland developmentGO:00074311620.012
regulation of purine nucleotide catabolic processGO:0033121480.012
regulation of neurogenesisGO:00507671580.012
cell cycle phase transitionGO:00447701400.012
regulation of mapk cascadeGO:0043408920.012
regulation of rhodopsin mediated signaling pathwayGO:0022400170.012
regulation of cell proliferationGO:00421271630.012
positive regulation of cellular amine metabolic processGO:003324000.012
response to glucoseGO:000974920.012
aromatic compound catabolic processGO:00194391660.012
canonical wnt signaling pathwayGO:0060070210.012
regulation of transferase activityGO:0051338580.012
sulfur compound metabolic processGO:0006790590.012
purine nucleoside triphosphate catabolic processGO:00091461080.012
positive regulation of protein metabolic processGO:00512471280.012
olfactory learningGO:0008355560.012
cuticle pattern formationGO:0035017270.012
establishment of protein localizationGO:00451841630.012
regulation of defense responseGO:00313471020.012
Mouse
positive regulation of nucleocytoplasmic transportGO:0046824240.012
cell junction assemblyGO:0034329420.012
torc1 signalingGO:0038202120.012
guanosine containing compound catabolic processGO:1901069740.012
regulation of protein metabolic processGO:00512462560.012
Mouse
amine metabolic processGO:0009308120.012
ameboidal type cell migrationGO:00016671510.011
axis specificationGO:00097981670.011
negative regulation of gene expressionGO:00106293870.011
regulation of kinase activityGO:0043549530.011
mapk cascadeGO:00001651070.011
regulation of reproductive processGO:2000241540.011
ribonucleoside triphosphate catabolic processGO:00092031080.011
positive regulation of cell motilityGO:200014730.011
heterocycle catabolic processGO:00467001660.011
cell cycle checkpointGO:0000075950.011
positive regulation of growthGO:0045927750.011
skeletal muscle fiber developmentGO:004874130.011
regulation of erk1 and erk2 cascadeGO:0070372390.011
endomembrane system organizationGO:00102561190.011
salivary gland cell autophagic cell deathGO:0035071830.011
cellular lipid metabolic processGO:0044255830.011
regulation of epithelial cell proliferationGO:005067840.011
regulation of proteasomal protein catabolic processGO:0061136390.011
carbohydrate derivative catabolic processGO:19011361180.011
gtp metabolic processGO:0046039720.011
larval developmentGO:00021641040.011
endosomal transportGO:0016197440.011
negative regulation of transforming growth factor beta receptor signaling pathwayGO:003051240.011
negative regulation of cytoskeleton organizationGO:0051494300.011
olfactory behaviorGO:0042048970.011
negative regulation of proteolysisGO:0045861310.011
negative regulation of protein phosphorylationGO:0001933170.011
Mouse
regulation of protein catabolic processGO:0042176550.011
axis elongationGO:000340130.011
antennal morphogenesisGO:0048800140.011
biological adhesionGO:00226101380.011
regulation of rho protein signal transductionGO:0035023200.011
epithelial cell developmentGO:00020642740.011
wnt signaling pathway planar cell polarity pathwayGO:006007160.011
negative regulation of notch signaling pathwayGO:0045746410.010
regulation of protein kinase activityGO:0045859510.010
positive regulation of ras gtpase activityGO:0032320360.010
forebrain developmentGO:003090020.010
rho protein signal transductionGO:0007266140.010
photoreceptor cell fate commitmentGO:0046552410.010
cellular response to organic substanceGO:00713101320.010
negative regulation of epithelial cell proliferationGO:005068040.010
mitotic sister chromatid separationGO:0051306300.010
cell agingGO:000756920.010
columnar cuboidal epithelial cell developmentGO:00020662490.010
ribonucleotide catabolic processGO:00092611090.010
leg disc morphogenesisGO:0007478800.010
gtp catabolic processGO:0006184720.010
posttranscriptional regulation of gene expressionGO:00106081450.010
stem cell differentiationGO:00488631170.010
r7 cell fate commitmentGO:0007465120.010

fray disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
cancerDOID:16200.025
disease of cellular proliferationDOID:1456600.025
organ system cancerDOID:005068600.015
disease of anatomical entityDOID:700.015
nervous system diseaseDOID:86300.012