IMP: Integrative Multi-species Prediction

Drosophila melanogaster

136 known processes

ik2 (Dmel_CG2615)

IkappaB kinase-like 2

(Aliases: IK2,Ik2/DmIKK,dIKK,l(2)38Ea,DmIKKepsilon,Dmel\CG2615,Dmik2,IKKepsilon,DmIKKepsilon/dIK2,APTX7,38D.31,CG2615,Ik2,IKK,dik2,Dik2,DIK2)

FLYBASE: FBgn0086657
Entrez: 35329
UniProtKB: Q9V3Y8

Process Predictions
Disease Predictions

ik2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
dendrite development	GO:0016358	204	1.000
dendrite morphogenesis	GO:0048813	199	0.994
cell migration	GO:0016477	238	0.991
epithelial cell migration	GO:0010631	148	0.977
regulation of multicellular organismal development	GO:2000026	414	0.969
cell maturation	GO:0048469	144	0.949
ovarian follicle cell development	GO:0030707	248	0.939
regulation of nervous system development	GO:0051960	248	0.927
neuromuscular junction development	GO:0007528	149	0.923
immune system process	GO:0002376	347	0.923	Mouse Fly
response to other organism	GO:0051707	293	0.920	Mouse Fly
small molecule metabolic process	GO:0044281	305	0.890
axonogenesis	GO:0007409	290	0.889
regulation of cell differentiation	GO:0045595	302	0.882
columnar cuboidal epithelial cell development	GO:0002066	249	0.873
purine ribonucleotide metabolic process	GO:0009150	145	0.873
ribose phosphate metabolic process	GO:0019693	145	0.864
regulation of neurogenesis	GO:0050767	158	0.858
chorion containing eggshell formation	GO:0007304	105	0.855
axon development	GO:0061564	297	0.847
immune response	GO:0006955	246	0.839	Mouse Fly
regulation of anatomical structure morphogenesis	GO:0022603	242	0.827
regulation of cell morphogenesis	GO:0022604	163	0.826
negative regulation of developmental process	GO:0051093	201	0.813
cell motility	GO:0048870	251	0.806
regulation of cell development	GO:0060284	215	0.796
organophosphate metabolic process	GO:0019637	195	0.783
epithelial cell development	GO:0002064	274	0.776
eye morphogenesis	GO:0048592	260	0.756
organonitrogen compound metabolic process	GO:1901564	318	0.751	Fly
neuron maturation	GO:0042551	31	0.748
chemotaxis	GO:0006935	249	0.738
ribonucleotide catabolic process	GO:0009261	109	0.716
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.701
male gamete generation	GO:0048232	201	0.699
neuron projection guidance	GO:0097485	241	0.696
ovarian follicle cell migration	GO:0007297	121	0.672
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.662
compound eye development	GO:0048749	307	0.641
actin filament based process	GO:0030029	220	0.630
gland development	GO:0048732	191	0.626
response to bacterium	GO:0009617	198	0.625	Mouse Fly
regulation of programmed cell death	GO:0043067	152	0.622
sensory organ morphogenesis	GO:0090596	260	0.610
axon guidance	GO:0007411	233	0.589
epithelium migration	GO:0090132	148	0.583
branching involved in open tracheal system development	GO:0060446	45	0.569
negative regulation of cell development	GO:0010721	62	0.565
compound eye morphogenesis	GO:0001745	249	0.530
regulation of cellular component biogenesis	GO:0044087	201	0.527
embryo development ending in birth or egg hatching	GO:0009792	152	0.524
purine nucleoside metabolic process	GO:0042278	127	0.520
synapse assembly	GO:0007416	143	0.515
death	GO:0016265	284	0.514
purine ribonucleoside metabolic process	GO:0046128	127	0.511
regulation of response to stress	GO:0080134	200	0.507	Mouse Fly
organic acid metabolic process	GO:0006082	103	0.492
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.483
nucleoside phosphate catabolic process	GO:1901292	110	0.478
endocytosis	GO:0006897	310	0.469
tissue morphogenesis	GO:0048729	297	0.450
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.447
negative regulation of neuroblast proliferation	GO:0007406	27	0.440
gastrulation involving germ band extension	GO:0010004	36	0.434
synaptic growth at neuromuscular junction	GO:0051124	119	0.433
nucleoside metabolic process	GO:0009116	127	0.425
regulation of localization	GO:0032879	275	0.421
regulation of immune system process	GO:0002682	176	0.420	Mouse Fly
carbohydrate derivative catabolic process	GO:1901136	118	0.410
neuron remodeling	GO:0016322	29	0.408
branching morphogenesis of an epithelial tube	GO:0048754	45	0.406
positive regulation of macromolecule metabolic process	GO:0010604	405	0.404
ameboidal type cell migration	GO:0001667	151	0.398
border follicle cell migration	GO:0007298	113	0.394
epithelial cell differentiation	GO:0030855	322	0.392
regulation of cell cycle phase transition	GO:1901987	130	0.383
localization of cell	GO:0051674	257	0.383
regulation of cell cycle	GO:0051726	291	0.379
positive regulation of molecular function	GO:0044093	136	0.378
response to external biotic stimulus	GO:0043207	293	0.371	Mouse Fly
ribonucleoside metabolic process	GO:0009119	127	0.362
positive regulation of cell development	GO:0010720	61	0.354
regulation of synapse organization	GO:0050807	110	0.350
programmed cell death	GO:0012501	257	0.346
developmental programmed cell death	GO:0010623	138	0.346
nucleobase containing small molecule metabolic process	GO:0055086	174	0.342
taxis	GO:0042330	304	0.330
vesicle mediated transport	GO:0016192	381	0.322
digestive tract morphogenesis	GO:0048546	127	0.321
mitotic cell cycle phase transition	GO:0044772	138	0.314
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.308
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.303	Human Fly
regulation of molecular function	GO:0065009	217	0.302
salivary gland morphogenesis	GO:0007435	145	0.294
lateral inhibition	GO:0046331	206	0.294
mesenchymal cell differentiation	GO:0048762	1	0.292
synapse organization	GO:0050808	196	0.289
developmental growth	GO:0048589	280	0.289
dna repair	GO:0006281	54	0.275
regulation of cytoskeleton organization	GO:0051493	89	0.268
regulation of apoptotic process	GO:0042981	130	0.265
regulation of catabolic process	GO:0009894	170	0.264
exocrine system development	GO:0035272	162	0.263
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.260
regulation of embryonic development	GO:0045995	68	0.251
negative regulation of programmed cell death	GO:0043069	72	0.249
nucleoside phosphate metabolic process	GO:0006753	162	0.247
central nervous system development	GO:0007417	201	0.246
cell type specific apoptotic process	GO:0097285	38	0.245
regulation of cellular catabolic process	GO:0031329	157	0.236
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.230
ribonucleoside catabolic process	GO:0042454	112	0.228
innate immune response	GO:0045087	144	0.227	Mouse Fly
nucleoside triphosphate metabolic process	GO:0009141	120	0.227
purine nucleotide catabolic process	GO:0006195	109	0.217
jak stat cascade	GO:0007259	49	0.216
regulation of cell cycle process	GO:0010564	181	0.212
nucleotide metabolic process	GO:0009117	161	0.211
cellular nitrogen compound catabolic process	GO:0044270	165	0.208
negative regulation of nervous system development	GO:0051961	92	0.206
carbohydrate derivative metabolic process	GO:1901135	217	0.202
regulation of synapse assembly	GO:0051963	94	0.202
regulation of dendrite morphogenesis	GO:0048814	28	0.199
dna metabolic process	GO:0006259	227	0.197
aromatic compound catabolic process	GO:0019439	166	0.193
purine containing compound metabolic process	GO:0072521	155	0.192
hematopoietic or lymphoid organ development	GO:0048534	57	0.191
nucleoside triphosphate catabolic process	GO:0009143	108	0.189
glycosyl compound catabolic process	GO:1901658	112	0.186
spermatogenesis	GO:0007283	200	0.184
morphogenesis of a branching epithelium	GO:0061138	45	0.183
glycosyl compound metabolic process	GO:1901657	127	0.180
gastrulation with mouth forming first	GO:0001703	36	0.174
regulation of cellular response to stress	GO:0080135	89	0.172
negative regulation of cell differentiation	GO:0045596	143	0.170
chromosome organization	GO:0051276	360	0.170
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.169
actin filament bundle organization	GO:0061572	28	0.166
regulation of immune response	GO:0050776	118	0.166	Mouse Fly
axis specification	GO:0009798	167	0.164
eggshell chorion assembly	GO:0007306	66	0.163
cellular response to dna damage stimulus	GO:0006974	223	0.160	Human
eye photoreceptor cell development	GO:0042462	81	0.159
protein complex biogenesis	GO:0070271	201	0.155
negative regulation of cell communication	GO:0010648	223	0.155
cell cycle phase transition	GO:0044770	140	0.153
negative regulation of neurogenesis	GO:0050768	53	0.152
regulation of axonogenesis	GO:0050770	32	0.152
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.151
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.149
digestive tract development	GO:0048565	149	0.149
cell death	GO:0008219	279	0.148
regulation of cell proliferation	GO:0042127	163	0.145
defense response to bacterium	GO:0042742	178	0.145	Mouse Fly
gastrulation	GO:0007369	70	0.144
cellular protein localization	GO:0034613	160	0.144
negative regulation of apoptotic process	GO:0043066	63	0.144
apoptotic process	GO:0006915	159	0.139
purine nucleoside catabolic process	GO:0006152	112	0.137
protein localization	GO:0008104	284	0.136
regulation of mitotic cell cycle	GO:0007346	190	0.135
digestive system development	GO:0055123	149	0.135
muscle organ development	GO:0007517	127	0.134
response to biotic stimulus	GO:0009607	294	0.134	Mouse Fly
purine containing compound catabolic process	GO:0072523	112	0.132
chaeta development	GO:0022416	97	0.132
developmental maturation	GO:0021700	172	0.131
dorsal appendage formation	GO:0046843	47	0.130
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.129	Human
regulation of gliogenesis	GO:0014013	11	0.128
regulation of cell death	GO:0010941	173	0.127
embryonic morphogenesis	GO:0048598	206	0.127
purine ribonucleotide catabolic process	GO:0009154	109	0.124
defense response	GO:0006952	300	0.123	Mouse Fly
actin cytoskeleton organization	GO:0030036	206	0.122
cellular response to extracellular stimulus	GO:0031668	64	0.122
positive regulation of developmental process	GO:0051094	143	0.120
regulation of growth	GO:0040008	233	0.118
larval development	GO:0002164	104	0.118
negative regulation of cell cycle	GO:0045786	116	0.116
syncytium formation	GO:0006949	43	0.116
phosphorylation	GO:0016310	294	0.113
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.113	Human
peptidyl tyrosine phosphorylation	GO:0018108	24	0.113
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.111	Human
dorsal closure	GO:0007391	79	0.111
gland morphogenesis	GO:0022612	145	0.110
macromolecular complex assembly	GO:0065003	256	0.109
defense response to other organism	GO:0098542	225	0.109	Mouse Fly
salivary gland development	GO:0007431	162	0.105
cell growth	GO:0016049	108	0.104
cellular component assembly involved in morphogenesis	GO:0010927	151	0.101
negative regulation of cellular component organization	GO:0051129	108	0.100
regulation of innate immune response	GO:0045088	71	0.100	Mouse Fly
endomembrane system organization	GO:0010256	119	0.096
phagocytosis	GO:0006909	215	0.095
regulation of gene expression epigenetic	GO:0040029	128	0.095
anterior posterior axis specification embryo	GO:0008595	103	0.093
neuroblast proliferation	GO:0007405	74	0.093
organic cyclic compound catabolic process	GO:1901361	168	0.091
regulation of stem cell proliferation	GO:0072091	40	0.090
meiosis i	GO:0007127	59	0.090
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.089
regulation of compound eye cone cell fate specification	GO:0042682	4	0.089
negative regulation of cell death	GO:0060548	81	0.088
mitotic spindle organization	GO:0007052	220	0.088
gliogenesis	GO:0042063	80	0.088
regulation of cellular localization	GO:0060341	136	0.087
regulation of vesicle mediated transport	GO:0060627	59	0.086
single organism catabolic process	GO:0044712	228	0.086
antimicrobial humoral response	GO:0019730	99	0.084	Fly
regulation of proteolysis	GO:0030162	87	0.084
positive regulation of rna biosynthetic process	GO:1902680	266	0.083	Human
intracellular signal transduction	GO:0035556	300	0.083	Human Mouse
dorsal ventral axis specification	GO:0009950	66	0.082
regulation of transport	GO:0051049	181	0.081
regulation of neuron projection development	GO:0010975	69	0.081
eye development	GO:0001654	323	0.080
regulation of cellular protein metabolic process	GO:0032268	243	0.080
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.076
peripheral nervous system neuron differentiation	GO:0048934	8	0.076
dna recombination	GO:0006310	32	0.076
compound eye photoreceptor cell differentiation	GO:0001751	140	0.075
protein complex assembly	GO:0006461	200	0.075
regulation of cellular amine metabolic process	GO:0033238	3	0.074
embryonic development via the syncytial blastoderm	GO:0001700	148	0.074
telencephalon development	GO:0021537	2	0.074
negative regulation of mitotic cell cycle	GO:0045930	109	0.074
positive regulation of phagocytosis engulfment	GO:0060100	1	0.073
imaginal disc fusion	GO:0046528	19	0.073
tracheal outgrowth open tracheal system	GO:0007426	18	0.070
oocyte axis specification	GO:0007309	108	0.069
nucleobase containing compound catabolic process	GO:0034655	165	0.069
negative regulation of cell cycle process	GO:0010948	109	0.068
morphogenesis of a branching structure	GO:0001763	45	0.068
regulation of embryonic cell shape	GO:0016476	30	0.068
carboxylic acid metabolic process	GO:0019752	92	0.067
cellular macromolecule localization	GO:0070727	220	0.067
anterior posterior pattern specification	GO:0009952	136	0.067
cell cycle checkpoint	GO:0000075	95	0.066
regulation of glial cell proliferation	GO:0060251	11	0.066
purine nucleotide metabolic process	GO:0006163	146	0.065
regulation of catalytic activity	GO:0050790	185	0.065
organophosphate catabolic process	GO:0046434	112	0.065
actin filament organization	GO:0007015	126	0.065
regionalization	GO:0003002	416	0.063
nucleotide catabolic process	GO:0009166	109	0.063
protein polymerization	GO:0051258	42	0.061
apical constriction	GO:0003383	18	0.060
tube development	GO:0035295	244	0.060
camera type eye development	GO:0043010	4	0.060
organonitrogen compound catabolic process	GO:1901565	128	0.060
proteolysis	GO:0006508	192	0.060
cellular response to chemical stimulus	GO:0070887	199	0.060
stem cell proliferation	GO:0072089	88	0.060
morphogenesis of embryonic epithelium	GO:0016331	94	0.059
immune system development	GO:0002520	57	0.059
positive regulation of catabolic process	GO:0009896	105	0.059
protein targeting to nucleus	GO:0044744	51	0.059
skeletal muscle organ development	GO:0060538	48	0.058
eye photoreceptor cell differentiation	GO:0001754	145	0.058
regulation of cellular amino acid metabolic process	GO:0006521	0	0.058
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.058
protein modification process	GO:0036211	438	0.057
positive regulation of catalytic activity	GO:0043085	118	0.056
rhabdomere development	GO:0042052	38	0.056
guanosine containing compound catabolic process	GO:1901069	74	0.056
cellular amino acid metabolic process	GO:0006520	61	0.055
negative regulation of multicellular organismal process	GO:0051241	142	0.054
body morphogenesis	GO:0010171	2	0.054
spermatid differentiation	GO:0048515	114	0.054
homeostatic process	GO:0042592	199	0.054
humoral immune response	GO:0006959	117	0.054	Fly
receptor mediated endocytosis	GO:0006898	21	0.053
response to transforming growth factor beta	GO:0071559	18	0.053
epithelial cell migration open tracheal system	GO:0007427	32	0.053
tube morphogenesis	GO:0035239	191	0.052
regulation of compound eye retinal cell programmed cell death	GO:0046669	18	0.051
respiratory system development	GO:0060541	213	0.051
response to abiotic stimulus	GO:0009628	341	0.051
detection of stimulus	GO:0051606	156	0.051
eggshell formation	GO:0030703	105	0.051
amine metabolic process	GO:0009308	12	0.050
regulation of actin filament length	GO:0030832	27	0.049
oxoacid metabolic process	GO:0043436	103	0.049
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.049
tissue death	GO:0016271	102	0.049
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.048
limb development	GO:0060173	1	0.047
histolysis	GO:0007559	102	0.046
morphogenesis of an epithelium	GO:0002009	276	0.046
regulation of execution phase of apoptosis	GO:1900117	5	0.045
cellular ketone metabolic process	GO:0042180	24	0.045
positive regulation of rna metabolic process	GO:0051254	271	0.045	Human
developmental growth involved in morphogenesis	GO:0060560	65	0.045
dna methylation or demethylation	GO:0044728	4	0.045
regulation of retinal cell programmed cell death	GO:0046668	18	0.044
tripartite regional subdivision	GO:0007351	103	0.044
mitotic dna damage checkpoint	GO:0044773	74	0.044
meiotic cell cycle process	GO:1903046	132	0.043
positive regulation of cellular component biogenesis	GO:0044089	80	0.043
mitotic cell cycle checkpoint	GO:0007093	88	0.043
salivary gland cell autophagic cell death	GO:0035071	83	0.043
protein palmitoylation	GO:0018345	2	0.042
heterocycle catabolic process	GO:0046700	166	0.042
regulation of cellular component size	GO:0032535	98	0.041
organic substance transport	GO:0071702	257	0.041
regulation of cell projection organization	GO:0031344	92	0.040
golgi organization	GO:0007030	66	0.040
germarium derived female germ line cyst encapsulation	GO:0030708	8	0.040
lipid localization	GO:0010876	54	0.039
purine ribonucleoside catabolic process	GO:0046130	112	0.039
cytoplasmic transport	GO:0016482	130	0.039
negative regulation of gene expression	GO:0010629	387	0.039	Mouse
cell activation	GO:0001775	9	0.039	Mouse
positive regulation of immune response	GO:0050778	63	0.039	Mouse Fly
tricarboxylic acid metabolic process	GO:0072350	1	0.039
growth	GO:0040007	359	0.039
cell fate determination	GO:0001709	91	0.038
gtp metabolic process	GO:0046039	72	0.038
regulation of intracellular signal transduction	GO:1902531	236	0.038	Human
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	12	0.038
terminal branching open tracheal system	GO:0007430	17	0.037
compound eye photoreceptor development	GO:0042051	78	0.037
ribonucleotide metabolic process	GO:0009259	145	0.037
regulation of neuron differentiation	GO:0045664	103	0.036
response to lipopolysaccharide	GO:0032496	4	0.036
head involution	GO:0008258	35	0.036
regulation of rho protein signal transduction	GO:0035023	20	0.036
tissue migration	GO:0090130	155	0.036
regulation of cell shape	GO:0008360	113	0.036
catabolic process	GO:0009056	409	0.035	Fly
epithelial tube morphogenesis	GO:0060562	88	0.035
nucleoside catabolic process	GO:0009164	112	0.035
nuclear import	GO:0051170	51	0.035
oocyte construction	GO:0007308	112	0.035
positive regulation of intracellular signal transduction	GO:1902533	116	0.035	Human
chaeta morphogenesis	GO:0008407	42	0.035
regulation of actin filament polymerization	GO:0030833	25	0.035
wound healing	GO:0042060	75	0.034
inter male aggressive behavior	GO:0002121	60	0.034
regulation of dendrite development	GO:0050773	37	0.034
regulation of actin polymerization or depolymerization	GO:0008064	27	0.034
response to decreased oxygen levels	GO:0036293	58	0.034
gene silencing	GO:0016458	138	0.033
cellular catabolic process	GO:0044248	372	0.033
photoreceptor cell development	GO:0042461	96	0.032
dna replication	GO:0006260	48	0.032
secretion by cell	GO:0032940	101	0.032
intracellular mrna localization involved in pattern specification process	GO:0060810	56	0.032
positive regulation of transcription dna templated	GO:0045893	266	0.032	Human
organic substance catabolic process	GO:1901575	308	0.032	Fly
photoreceptor cell differentiation	GO:0046530	170	0.032
embryonic axis specification	GO:0000578	107	0.031
purine nucleoside monophosphate catabolic process	GO:0009128	38	0.031
cellular macromolecular complex assembly	GO:0034622	153	0.031
cellular amine metabolic process	GO:0044106	12	0.031
regulation of cell size	GO:0008361	63	0.031
regulation of protein metabolic process	GO:0051246	256	0.031
chromatin organization	GO:0006325	207	0.031
positive regulation of signal transduction	GO:0009967	223	0.030	Human
organelle localization	GO:0051640	148	0.030
protein catabolic process	GO:0030163	101	0.029	Fly
regulation of neuroblast proliferation	GO:1902692	34	0.029
positive regulation of cellular component organization	GO:0051130	156	0.029
positive regulation of proteolysis	GO:0045862	52	0.029
germarium derived egg chamber formation	GO:0007293	101	0.029
cell recognition	GO:0008037	102	0.029
phagocytosis engulfment	GO:0006911	11	0.029
regulation of anatomical structure size	GO:0090066	163	0.029
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.028	Human
spermatid development	GO:0007286	98	0.028
cell division	GO:0051301	248	0.028
protein localization to nucleus	GO:0034504	55	0.028
forebrain development	GO:0030900	2	0.028
positive regulation of immune system process	GO:0002684	68	0.027	Mouse Fly
positive regulation of cell migration	GO:0030335	2	0.027
apoptotic signaling pathway	GO:0097190	27	0.027	Human
cortical actin cytoskeleton organization	GO:0030866	24	0.027
regulation of chromosome organization	GO:0033044	64	0.026
negative regulation of stem cell proliferation	GO:2000647	30	0.026
regulation of cell cycle g1 s phase transition	GO:1902806	23	0.026
r7 cell differentiation	GO:0045466	43	0.026
initiation of dorsal closure	GO:0007392	12	0.026
embryonic digestive tract development	GO:0048566	5	0.025
establishment or maintenance of cytoskeleton polarity	GO:0030952	44	0.025
embryonic pattern specification	GO:0009880	174	0.025
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.025
regulation of neural precursor cell proliferation	GO:2000177	35	0.025
negative regulation of cellular metabolic process	GO:0031324	382	0.025
protein import into nucleus	GO:0006606	51	0.025
brain development	GO:0007420	120	0.024
hemocyte development	GO:0007516	7	0.024
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.024
locomotory behavior	GO:0007626	176	0.024
embryonic digestive tract morphogenesis	GO:0048557	4	0.023
oocyte microtubule cytoskeleton organization	GO:0016325	35	0.023
cortical cytoskeleton organization	GO:0030865	29	0.023
developmental cell growth	GO:0048588	52	0.023
regulation of synapse structure and activity	GO:0050803	128	0.023
execution phase of apoptosis	GO:0097194	7	0.023
regulation of actin filament based process	GO:0032970	42	0.023
regulation of organ morphogenesis	GO:2000027	78	0.023
positive regulation of multicellular organismal process	GO:0051240	143	0.023	Human Mouse
muscle cell differentiation	GO:0042692	103	0.022
sex differentiation	GO:0007548	81	0.022
regulation of response to external stimulus	GO:0032101	115	0.022	Fly
response to wounding	GO:0009611	94	0.022
ion transport	GO:0006811	145	0.022
muscle structure development	GO:0061061	224	0.022
dna biosynthetic process	GO:0071897	24	0.021
actin filament bundle assembly	GO:0051017	26	0.021
response to ionizing radiation	GO:0010212	32	0.021
positive regulation of cellular protein metabolic process	GO:0032270	118	0.021
segmentation	GO:0035282	207	0.021
oocyte nucleus localization involved in oocyte dorsal ventral axis specification	GO:0051663	12	0.020
cellular protein modification process	GO:0006464	438	0.020
regulation of jak stat cascade	GO:0046425	43	0.020
retinal cone cell differentiation	GO:0042670	2	0.020
regulation of cell motility	GO:2000145	23	0.020
gtp catabolic process	GO:0006184	72	0.020
regulation of protein acetylation	GO:1901983	7	0.020
establishment of protein localization	GO:0045184	163	0.020
negative regulation of cell proliferation	GO:0008285	69	0.020
organelle assembly	GO:0070925	198	0.020
positive regulation of cell communication	GO:0010647	250	0.020	Human
cellular protein complex assembly	GO:0043623	71	0.020
positive regulation of dendrite morphogenesis	GO:0050775	9	0.020
regulation of phosphate metabolic process	GO:0019220	210	0.019
regulation of response to dna damage stimulus	GO:2001020	23	0.019
chemical homeostasis	GO:0048878	92	0.019
actin polymerization or depolymerization	GO:0008154	31	0.019
dorsal ventral pattern formation	GO:0009953	133	0.019
cellular response to organic substance	GO:0071310	132	0.019
apical constriction involved in gastrulation	GO:0003384	7	0.019
positive regulation of cell differentiation	GO:0045597	64	0.019
positive regulation of biosynthetic process	GO:0009891	316	0.019	Human Mouse Fly
regulation of axon extension	GO:0030516	8	0.019
chromosome segregation	GO:0007059	157	0.019
regulation of developmental growth	GO:0048638	174	0.019
positive regulation of organelle organization	GO:0010638	65	0.018
single organism nuclear import	GO:1902593	51	0.018
regulation of protein localization	GO:0032880	76	0.018
salivary gland histolysis	GO:0035070	88	0.018
muscle attachment	GO:0016203	36	0.018
negative regulation of cellular protein metabolic process	GO:0032269	85	0.018
g1 s transition of mitotic cell cycle	GO:0000082	31	0.018
cellular homeostasis	GO:0019725	80	0.018
regulation of protein polymerization	GO:0032271	28	0.018
negative regulation of cell cycle g1 s phase transition	GO:1902807	13	0.018
asymmetric cell division	GO:0008356	37	0.018
regulation of multi organism process	GO:0043900	131	0.018	Fly
epithelial cell morphogenesis	GO:0003382	25	0.018
pupariation	GO:0035073	14	0.017
defense response to gram negative bacterium	GO:0050829	94	0.017
retina development in camera type eye	GO:0060041	4	0.017
mitotic cell cycle embryonic	GO:0045448	38	0.017
negative regulation of cell cycle phase transition	GO:1901988	103	0.017
glial cell differentiation	GO:0010001	35	0.017
regulation of peptidyl lysine acetylation	GO:2000756	7	0.017
meiotic nuclear division	GO:0007126	151	0.017
gonad development	GO:0008406	50	0.017
response to hypoxia	GO:0001666	53	0.017
mesenchymal cell development	GO:0014031	1	0.017
regulation of cysteine type endopeptidase activity	GO:2000116	27	0.017
positive regulation of actin filament polymerization	GO:0030838	11	0.017
actin filament polymerization	GO:0030041	27	0.017
posttranscriptional gene silencing	GO:0016441	46	0.016
positive regulation of response to stimulus	GO:0048584	323	0.016	Human Mouse Fly
regulation of locomotion	GO:0040012	42	0.016
positive regulation of synapse assembly	GO:0051965	29	0.016
protein acylation	GO:0043543	42	0.016
establishment of protein localization to organelle	GO:0072594	62	0.016
centrosome duplication	GO:0051298	121	0.016
blastoderm segmentation	GO:0007350	159	0.016
regulation of phosphatase activity	GO:0010921	3	0.016
protein modification by small protein conjugation or removal	GO:0070647	106	0.016
peripheral nervous system neuron development	GO:0048935	8	0.016
neuron projection extension involved in neuron projection guidance	GO:1902284	10	0.016
negative regulation of synaptic growth at neuromuscular junction	GO:0045886	39	0.015
regulation of secretion by cell	GO:1903530	39	0.015
positive regulation of protein complex assembly	GO:0031334	22	0.015
regulation of organelle organization	GO:0033043	196	0.015
regulation of epithelial cell proliferation	GO:0050678	4	0.015
mesodermal cell migration	GO:0008078	7	0.015
hematopoietic progenitor cell differentiation	GO:0002244	1	0.015
actomyosin structure organization	GO:0031032	56	0.015
cell proliferation	GO:0008283	299	0.015	Mouse
unidimensional cell growth	GO:0009826	15	0.015
stem cell development	GO:0048864	79	0.015
syncytium formation by plasma membrane fusion	GO:0000768	43	0.015
positive regulation of cellular amine metabolic process	GO:0033240	0	0.015
protein transport	GO:0015031	155	0.015
atp metabolic process	GO:0046034	49	0.015
muscle cell development	GO:0055001	50	0.015
organonitrogen compound biosynthetic process	GO:1901566	117	0.015	Fly
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	4	0.015
regulation of protein transport	GO:0051223	57	0.015
chromatin silencing	GO:0006342	76	0.015
meiotic cytokinesis	GO:0033206	33	0.014

ik2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org

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