IMP: Integrative Multi-species Prediction

Drosophila melanogaster

146 known processes

htl (Dmel_CG7223)

heartless

(Aliases: DmHD-38,DFGF-R2,DFGF-R1,Dmel\CG7223,DPR3,dtk1,DFR-1,FR1,FGF-R2,i150,Tk1,HTL/FGFR1,Dtk1,FGFR,j372,EMS2,DFR1/DFGF-R2,CT39172,DTRK(FR1),DFR1,Fr1,FGFR2,i79,CG7223,Dfr1,CT22273,Htl,Dfr-1,HD-38,i100)

FLYBASE: FBgn0010389
Entrez: 42160
UniProtKB: Q07407

Process Predictions
Disease Predictions

htl biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
muscle structure development	GO:0061061	224	0.999
muscle attachment	GO:0016203	36	0.997
mesoderm development	GO:0007498	78	0.997
cell migration	GO:0016477	238	0.996
glial cell migration	GO:0008347	31	0.991
skeletal muscle organ development	GO:0060538	48	0.987
muscle organ development	GO:0007517	127	0.986
cell motility	GO:0048870	251	0.985
localization of cell	GO:0051674	257	0.981
gliogenesis	GO:0042063	80	0.978
tube development	GO:0035295	244	0.971
nephrocyte differentiation	GO:0061319	12	0.971
mesoderm morphogenesis	GO:0048332	22	0.969
regulation of cell development	GO:0060284	215	0.967	Human Mouse Rat Fly
regulation of multicellular organismal development	GO:2000026	414	0.962	Human Zebrafish Mouse Rat Fly
myoblast fusion	GO:0007520	43	0.946
neuron projection guidance	GO:0097485	241	0.937	Worm
chemotaxis	GO:0006935	249	0.936	Worm
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.932
axonogenesis	GO:0007409	290	0.926	Mouse Worm Fly
regulation of neurogenesis	GO:0050767	158	0.922	Human Mouse Rat Fly
embryonic organ development	GO:0048568	50	0.917	Human Mouse
regulation of phosphorus metabolic process	GO:0051174	210	0.908	Human Mouse Rat Fly
heart development	GO:0007507	82	0.906
larval visceral muscle development	GO:0007523	9	0.906
mesoderm formation	GO:0001707	21	0.902
muscle cell differentiation	GO:0042692	103	0.887
embryonic morphogenesis	GO:0048598	206	0.866
pericardial nephrocyte differentiation	GO:0061320	9	0.849
tube morphogenesis	GO:0035239	191	0.810
urogenital system development	GO:0001655	72	0.788
formation of primary germ layer	GO:0001704	24	0.786
tissue morphogenesis	GO:0048729	297	0.781
mesodermal cell fate commitment	GO:0001710	7	0.779
embryonic heart tube development	GO:0035050	22	0.778
renal filtration cell differentiation	GO:0061318	12	0.775
developmental growth involved in morphogenesis	GO:0060560	65	0.770	Mouse Fly
appendage morphogenesis	GO:0035107	397	0.769	Mouse
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.760	Human Zebrafish Mouse Rat Worm
regulation of phosphate metabolic process	GO:0019220	210	0.754	Human Mouse Rat Fly
cellular protein modification process	GO:0006464	438	0.748	Human Zebrafish Mouse Rat Worm Fly
glial cell development	GO:0021782	27	0.732	Mouse
cellular response to chemical stimulus	GO:0070887	199	0.730	Human Zebrafish Mouse Rat Worm
multi organism behavior	GO:0051705	175	0.728	Worm
protein modification process	GO:0036211	438	0.718	Human Zebrafish Mouse Rat Worm Fly
phosphorylation	GO:0016310	294	0.714	Human Zebrafish Mouse Rat Worm Fly
wing disc morphogenesis	GO:0007472	344	0.714
appendage development	GO:0048736	401	0.707	Mouse
circulatory system development	GO:0072359	82	0.706
epithelial cell migration	GO:0010631	148	0.699	Fly
positive regulation of molecular function	GO:0044093	136	0.696	Human Fly
larval somatic muscle development	GO:0007526	19	0.684
cardiovascular system development	GO:0072358	82	0.683
syncytium formation by plasma membrane fusion	GO:0000768	43	0.674
positive regulation of phosphate metabolic process	GO:0045937	139	0.647	Human Mouse Rat Fly
ameboidal type cell migration	GO:0001667	151	0.647
post embryonic appendage morphogenesis	GO:0035120	385	0.641
synapse organization	GO:0050808	196	0.628	Mouse
growth	GO:0040007	359	0.628	Zebrafish Mouse Fly
synaptic growth at neuromuscular junction	GO:0051124	119	0.627
regulation of neuron differentiation	GO:0045664	103	0.626	Human Mouse Rat Fly
intracellular signal transduction	GO:0035556	300	0.612	Human Mouse Rat Fly
positive regulation of nervous system development	GO:0051962	69	0.601	Human Mouse Rat
cardiocyte differentiation	GO:0035051	29	0.597
stem cell differentiation	GO:0048863	117	0.585
renal system development	GO:0072001	72	0.557
imaginal disc derived wing morphogenesis	GO:0007476	337	0.551
motor neuron axon guidance	GO:0008045	58	0.547
amine metabolic process	GO:0009308	12	0.542
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.531	Human Mouse Rat
digestive tract development	GO:0048565	149	0.529
cell adhesion	GO:0007155	136	0.522
striated muscle cell differentiation	GO:0051146	90	0.505
actin cytoskeleton organization	GO:0030036	206	0.504
regulation of cell cell adhesion	GO:0022407	21	0.494
positive regulation of macromolecule metabolic process	GO:0010604	405	0.487	Human Mouse Rat Fly
developmental growth	GO:0048589	280	0.480	Zebrafish Mouse Fly
cardioblast differentiation	GO:0010002	20	0.479
regulation of nervous system development	GO:0051960	248	0.476	Human Mouse Rat Fly
organic acid metabolic process	GO:0006082	103	0.474	Human Mouse
regulation of cell differentiation	GO:0045595	302	0.468	Human Zebrafish Mouse Rat Fly
morphogenesis of embryonic epithelium	GO:0016331	94	0.463	Mouse
mesodermal cell differentiation	GO:0048333	7	0.463
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.461	Mouse Rat
protein phosphorylation	GO:0006468	169	0.459	Human Zebrafish Mouse Rat Worm Fly
gastrulation	GO:0007369	70	0.457
compound eye development	GO:0048749	307	0.445
regulation of phosphorylation	GO:0042325	147	0.444	Human Mouse Rat Fly
regulation of protein metabolic process	GO:0051246	256	0.443	Human Mouse Fly
heart morphogenesis	GO:0003007	32	0.443	Mouse
synapse assembly	GO:0007416	143	0.441
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.435	Mouse
regulation of protein modification process	GO:0031399	112	0.434	Human Mouse Fly
regulation of phosphatidylinositol 3 kinase activity	GO:0043551	2	0.433	Human
regulation of cellular protein metabolic process	GO:0032268	243	0.425	Human Mouse Fly
regulation of anatomical structure morphogenesis	GO:0022603	242	0.424
imaginal disc derived appendage development	GO:0048737	399	0.424
cellular amine metabolic process	GO:0044106	12	0.423
cell migration involved in gastrulation	GO:0042074	9	0.419
positive regulation of phosphorus metabolic process	GO:0010562	139	0.414	Human Mouse Rat Fly
connective tissue development	GO:0061448	3	0.414	Mouse
gland morphogenesis	GO:0022612	145	0.413	Mouse
skeletal muscle fiber development	GO:0048741	3	0.410
neurological system process	GO:0050877	358	0.408	Mouse Rat
oocyte development	GO:0048599	124	0.404
actin filament based process	GO:0030029	220	0.404
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.390
dorsal closure	GO:0007391	79	0.388
regulation of cellular amino acid metabolic process	GO:0006521	0	0.383
regulation of intracellular signal transduction	GO:1902531	236	0.383	Human Mouse Rat Fly
single organismal cell cell adhesion	GO:0016337	45	0.379
neuromuscular junction development	GO:0007528	149	0.378	Mouse
bmp signaling pathway	GO:0030509	27	0.377
kidney development	GO:0001822	3	0.372	Mouse
axon development	GO:0061564	297	0.372	Mouse Worm Fly
cellular lipid metabolic process	GO:0044255	83	0.371	Human
syncytium formation	GO:0006949	43	0.366
single organism biosynthetic process	GO:0044711	206	0.365	Human Mouse
salivary gland development	GO:0007431	162	0.362	Mouse
regulation of cellular ketone metabolic process	GO:0010565	3	0.362	Human Mouse
nephron development	GO:0072006	3	0.351
cell fate specification	GO:0001708	71	0.350	Zebrafish Mouse Fly
regulation of developmental growth	GO:0048638	174	0.349	Mouse Fly
oocyte differentiation	GO:0009994	145	0.347
taxis	GO:0042330	304	0.345	Worm
digestive tract morphogenesis	GO:0048546	127	0.341
purine containing compound metabolic process	GO:0072521	155	0.339
positive regulation of gliogenesis	GO:0014015	5	0.336
regulation of reproductive process	GO:2000241	54	0.332	Mouse
embryonic development via the syncytial blastoderm	GO:0001700	148	0.329
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.325	Mouse
axon guidance	GO:0007411	233	0.324	Worm
visceral muscle development	GO:0007522	14	0.320
regulation of peptidyl tyrosine phosphorylation	GO:0050730	10	0.318	Human Mouse
response to organic substance	GO:0010033	284	0.315	Human Zebrafish Mouse Rat Worm
organonitrogen compound metabolic process	GO:1901564	318	0.310
regulation of mapk cascade	GO:0043408	92	0.309	Human Mouse Rat Fly
small molecule metabolic process	GO:0044281	305	0.300	Human Mouse
glial cell differentiation	GO:0010001	35	0.298
regulation of organ morphogenesis	GO:2000027	78	0.298	Mouse
anatomical structure homeostasis	GO:0060249	97	0.297	Zebrafish
myotube cell development	GO:0014904	3	0.291
regulation of cellular catabolic process	GO:0031329	157	0.289
determination of muscle attachment site	GO:0016204	7	0.284
digestive system development	GO:0055123	149	0.282
transmembrane transport	GO:0055085	139	0.281
oxoacid metabolic process	GO:0043436	103	0.281	Human Mouse
regulation of synapse structure and activity	GO:0050803	128	0.278
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.277
regulation of cellular amine metabolic process	GO:0033238	3	0.269
cellular response to amino acid stimulus	GO:0071230	6	0.267
regulation of erbb signaling pathway	GO:1901184	42	0.262
cellular amino acid metabolic process	GO:0006520	61	0.255
regulation of localization	GO:0032879	275	0.253
somatic muscle development	GO:0007525	66	0.252
regulation of epithelial cell proliferation	GO:0050678	4	0.249	Mouse Rat
signal transduction by phosphorylation	GO:0023014	107	0.249	Human Mouse Rat Fly
endodermal cell differentiation	GO:0035987	3	0.245
regulation of catabolic process	GO:0009894	170	0.242
positive regulation of cellular component organization	GO:0051130	156	0.240	Mouse Rat
embryonic pattern specification	GO:0009880	174	0.240	Mouse
positive regulation of phagocytosis	GO:0050766	3	0.237
positive regulation of cell proliferation	GO:0008284	47	0.236	Human Mouse Rat
glycosyl compound catabolic process	GO:1901658	112	0.233
positive regulation of protein metabolic process	GO:0051247	128	0.232	Human Mouse Fly
single organism cell adhesion	GO:0098602	47	0.231
head development	GO:0060322	135	0.230	Zebrafish Mouse Rat
positive regulation of glial cell proliferation	GO:0060252	5	0.230
sex differentiation	GO:0007548	81	0.226
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.223	Human Zebrafish Mouse Rat Worm
tissue migration	GO:0090130	155	0.219
response to fibroblast growth factor	GO:0071774	10	0.219	Human Zebrafish Mouse Rat Worm
positive regulation of cellular amine metabolic process	GO:0033240	0	0.215
determination of bilateral symmetry	GO:0009855	13	0.213	Zebrafish
regulation of cell proliferation	GO:0042127	163	0.211	Human Mouse Rat
regulation of actin filament based process	GO:0032970	42	0.210
positive regulation of phosphorylation	GO:0042327	87	0.209	Human Mouse Rat Fly
regulation of cellular component biogenesis	GO:0044087	201	0.206
extracellular structure organization	GO:0043062	46	0.205	Human
wnt signaling pathway	GO:0016055	98	0.203	Mouse
regulation of cell projection organization	GO:0031344	92	0.200	Mouse Rat Worm Fly
immune response	GO:0006955	246	0.200
cellular protein localization	GO:0034613	160	0.194
negative regulation of cell differentiation	GO:0045596	143	0.192	Zebrafish Mouse Rat Fly
endodermal cell fate commitment	GO:0001711	3	0.190
positive regulation of cellular catabolic process	GO:0031331	95	0.188
negative regulation of erbb signaling pathway	GO:1901185	29	0.188
organ formation	GO:0048645	39	0.186	Mouse
negative regulation of nervous system development	GO:0051961	92	0.183	Mouse Fly
carboxylic acid metabolic process	GO:0019752	92	0.182	Human Mouse
developmental maturation	GO:0021700	172	0.181	Mouse
peripheral nervous system development	GO:0007422	52	0.180
blood circulation	GO:0008015	26	0.179
negative regulation of rna biosynthetic process	GO:1902679	240	0.178	Mouse
negative regulation of response to stimulus	GO:0048585	258	0.177	Mouse
sensory perception of mechanical stimulus	GO:0050954	72	0.177	Mouse
oviposition	GO:0018991	19	0.173	Worm
cellular component assembly involved in morphogenesis	GO:0010927	151	0.172	Zebrafish
regulation of molecular function	GO:0065009	217	0.170	Human Fly
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.169	Human Mouse Rat
positive regulation of muscle organ development	GO:0048636	6	0.168	Mouse
positive regulation of biosynthetic process	GO:0009891	316	0.167	Human Mouse Rat
myotube differentiation	GO:0014902	46	0.166
positive regulation of cellular component biogenesis	GO:0044089	80	0.164
regulation of synapse assembly	GO:0051963	94	0.162
ribonucleotide metabolic process	GO:0009259	145	0.161
multi multicellular organism process	GO:0044706	123	0.160	Worm
activation of rac gtpase activity	GO:0032863	3	0.160
transcription from rna polymerase ii promoter	GO:0006366	368	0.159	Mouse Rat
embryonic hemopoiesis	GO:0035162	26	0.159
purine nucleoside metabolic process	GO:0042278	127	0.157
negative regulation of fibroblast growth factor receptor signaling pathway	GO:0040037	2	0.156
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.155	Mouse Rat
chromatin organization	GO:0006325	207	0.155
negative regulation of cellular component organization	GO:0051129	108	0.154	Mouse Fly
malpighian tubule development	GO:0072002	64	0.153
positive regulation of cellular biosynthetic process	GO:0031328	316	0.152	Human Mouse Rat
cell chemotaxis	GO:0060326	6	0.152
actin filament bundle organization	GO:0061572	28	0.151
positive regulation of transcription dna templated	GO:0045893	266	0.151	Mouse Rat
regulation of cellular component movement	GO:0051270	42	0.149
muscle fiber development	GO:0048747	12	0.149
positive regulation of response to stimulus	GO:0048584	323	0.148
germ cell migration	GO:0008354	43	0.139
specification of symmetry	GO:0009799	13	0.139	Zebrafish
positive regulation of cell communication	GO:0010647	250	0.139	Human Mouse Rat Fly
cell fate commitment involved in formation of primary germ layer	GO:0060795	10	0.138
positive regulation of multicellular organismal process	GO:0051240	143	0.137	Human Mouse Rat
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.137
response to oxygen containing compound	GO:1901700	200	0.136
kidney epithelium development	GO:0072073	3	0.136	Mouse
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.136
negative regulation of biosynthetic process	GO:0009890	277	0.135	Mouse
cell fate determination	GO:0001709	91	0.135
morphogenesis of a polarized epithelium	GO:0001738	93	0.135
regulation of stress fiber assembly	GO:0051492	6	0.134
regulation of apoptotic process	GO:0042981	130	0.133	Mouse
salivary gland morphogenesis	GO:0007435	145	0.132	Mouse
regulation of catalytic activity	GO:0050790	185	0.130	Human Fly
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.128	Mouse Rat
positive regulation of cell development	GO:0010720	61	0.128	Human Mouse Rat
formation of anatomical boundary	GO:0048859	37	0.128
defense response	GO:0006952	300	0.128
digestive tract mesoderm development	GO:0007502	5	0.125
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.125
skeletal muscle tissue development	GO:0007519	13	0.122
cation homeostasis	GO:0055080	51	0.122
formation of organ boundary	GO:0010160	30	0.121
camera type eye morphogenesis	GO:0048593	2	0.121	Mouse
regulation of actin cytoskeleton organization	GO:0032956	42	0.119
striated muscle tissue development	GO:0014706	27	0.118	Zebrafish Mouse
actin filament organization	GO:0007015	126	0.116
nucleobase containing small molecule metabolic process	GO:0055086	174	0.116
cellular ketone metabolic process	GO:0042180	24	0.115	Human Mouse
cardiac cell fate commitment	GO:0060911	17	0.115
ion transmembrane transport	GO:0034220	122	0.114
rhythmic behavior	GO:0007622	76	0.114
peptidyl tyrosine modification	GO:0018212	24	0.114	Human Zebrafish Mouse Rat Fly
establishment of tissue polarity	GO:0007164	87	0.113
positive regulation of lipid metabolic process	GO:0045834	4	0.112	Human
convergent extension involved in gastrulation	GO:0060027	2	0.111
regulation of ras gtpase activity	GO:0032318	38	0.111
regulation of hydrolase activity	GO:0051336	97	0.110	Human
single organism behavior	GO:0044708	391	0.110
multi organism reproductive behavior	GO:0044705	121	0.110	Worm
positive regulation of hydrolase activity	GO:0051345	78	0.110	Human
actomyosin structure organization	GO:0031032	56	0.109
negative regulation of cellular metabolic process	GO:0031324	382	0.109	Mouse
organelle assembly	GO:0070925	198	0.108	Zebrafish
positive regulation of phagocytosis engulfment	GO:0060100	1	0.107
inositol lipid mediated signaling	GO:0048017	4	0.107
negative regulation of transcription dna templated	GO:0045892	237	0.107	Mouse
aging	GO:0007568	143	0.106
positive regulation of cell motility	GO:2000147	3	0.105
cellular response to oxygen containing compound	GO:1901701	79	0.105
negative regulation of developmental process	GO:0051093	201	0.104	Zebrafish Mouse Rat Fly
epithelial cell morphogenesis involved in gastrulation	GO:0003381	7	0.104
death	GO:0016265	284	0.104	Human Mouse
nephron epithelium development	GO:0072009	3	0.103
cgmp metabolic process	GO:0046068	11	0.102
regionalization	GO:0003002	416	0.102	Zebrafish Mouse
body morphogenesis	GO:0010171	2	0.101
ribose phosphate metabolic process	GO:0019693	145	0.099
cellular macromolecule localization	GO:0070727	220	0.099
mesodermal cell migration	GO:0008078	7	0.099
negative regulation of rna metabolic process	GO:0051253	251	0.099	Mouse
biological adhesion	GO:0022610	138	0.098
regulation of epithelial cell migration open tracheal system	GO:2000274	11	0.097
epithelium migration	GO:0090132	148	0.096	Fly
cell maturation	GO:0048469	144	0.096	Mouse
regulation of synapse organization	GO:0050807	110	0.095
renal filtration	GO:0097205	7	0.095
purine nucleotide metabolic process	GO:0006163	146	0.092
regulation of neuron projection development	GO:0010975	69	0.092	Mouse Rat Fly
regulation of cell growth	GO:0001558	43	0.092	Fly
negative regulation of protein phosphorylation	GO:0001933	17	0.091
response to growth factor	GO:0070848	31	0.091	Human Zebrafish Mouse Rat Worm
response to organonitrogen compound	GO:0010243	75	0.091
purine ribonucleotide metabolic process	GO:0009150	145	0.091
homeostatic process	GO:0042592	199	0.091	Zebrafish Mouse
regulation of transferase activity	GO:0051338	58	0.090	Human Fly
positive regulation of behavior	GO:0048520	19	0.090
morphogenesis of an epithelium	GO:0002009	276	0.090	Zebrafish Mouse Fly
response to endogenous stimulus	GO:0009719	119	0.090	Human Zebrafish Mouse Rat Worm
oocyte maturation	GO:0001556	3	0.090
segmentation	GO:0035282	207	0.090
cardiac cell fate determination	GO:0060913	3	0.089
neuron recognition	GO:0008038	101	0.089
positive regulation of cell migration	GO:0030335	2	0.088
cardioblast cell fate determination	GO:0007510	3	0.088
ventral cord development	GO:0007419	16	0.087
negative regulation of phosphate metabolic process	GO:0045936	45	0.087
negative regulation of signaling	GO:0023057	219	0.084	Mouse
negative regulation of multicellular organismal process	GO:0051241	142	0.084	Zebrafish Mouse Rat Fly
nucleoside triphosphate metabolic process	GO:0009141	120	0.084
organophosphate metabolic process	GO:0019637	195	0.084	Human
regulation of response to stress	GO:0080134	200	0.084
activation of protein kinase activity	GO:0032147	12	0.083	Fly
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.083
regulation of protein phosphorylation	GO:0001932	64	0.083	Human Mouse Fly
rho protein signal transduction	GO:0007266	14	0.083
regulation of cell motility	GO:2000145	23	0.082
positive regulation of developmental process	GO:0051094	143	0.081	Human Mouse Rat
ion transport	GO:0006811	145	0.081
regulation of growth	GO:0040008	233	0.080	Mouse Fly
regulation of cellular component size	GO:0032535	98	0.080	Fly
cellular catabolic process	GO:0044248	372	0.079
regulation of epithelial cell migration	GO:0010632	12	0.079
regulation of purine nucleotide metabolic process	GO:1900542	62	0.077
nucleotide metabolic process	GO:0009117	161	0.077
carbohydrate derivative metabolic process	GO:1901135	217	0.076
central nervous system development	GO:0007417	201	0.076
chorion containing eggshell formation	GO:0007304	105	0.075
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	4	0.074	Human Mouse
regulation of anatomical structure size	GO:0090066	163	0.074	Fly
cellular response to growth factor stimulus	GO:0071363	30	0.074	Human Zebrafish Mouse Rat Worm
cranial nerve development	GO:0021545	1	0.074	Zebrafish
peptidyl amino acid modification	GO:0018193	105	0.073	Human Zebrafish Mouse Rat Fly
regulation of wnt signaling pathway	GO:0030111	68	0.073	Mouse
regulation of cell cycle	GO:0051726	291	0.072	Mouse
mesodermal cell fate specification	GO:0007501	2	0.072	Mouse
response to biotic stimulus	GO:0009607	294	0.072
regulation of protein kinase activity	GO:0045859	51	0.071	Human Fly
reproductive system development	GO:0061458	74	0.071
actin cytoskeleton reorganization	GO:0031532	22	0.071
blastoderm segmentation	GO:0007350	159	0.071
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.070	Mouse
response to ethanol	GO:0045471	59	0.070
small gtpase mediated signal transduction	GO:0007264	88	0.068
camera type eye development	GO:0043010	4	0.068	Mouse
forebrain development	GO:0030900	2	0.067	Mouse Rat
regulation of locomotion	GO:0040012	42	0.067
regulation of cell migration	GO:0030334	22	0.067
actin filament bundle assembly	GO:0051017	26	0.067
pericardium morphogenesis	GO:0003344	2	0.066
regulation of cell death	GO:0010941	173	0.066	Mouse
nucleoside metabolic process	GO:0009116	127	0.065
positive regulation of protein complex assembly	GO:0031334	22	0.065
epithelial cell migration open tracheal system	GO:0007427	32	0.065	Fly
regulation of bmp signaling pathway	GO:0030510	23	0.065
positive regulation of catabolic process	GO:0009896	105	0.064
reproductive structure development	GO:0048608	74	0.064
positive regulation of catalytic activity	GO:0043085	118	0.064	Human Fly
purine ribonucleoside metabolic process	GO:0046128	127	0.064
synaptic transmission	GO:0007268	288	0.063	Mouse
cell proliferation	GO:0008283	299	0.063	Human Zebrafish Mouse Rat
associative learning	GO:0008306	65	0.063
larval heart development	GO:0007508	6	0.062
regulation of cell morphogenesis	GO:0022604	163	0.062
inorganic cation transmembrane transport	GO:0098662	61	0.062
oocyte growth	GO:0001555	5	0.062
cellular response to endogenous stimulus	GO:0071495	80	0.062	Human Zebrafish Mouse Rat Worm
cellular protein complex assembly	GO:0043623	71	0.061
embryonic hindgut morphogenesis	GO:0048619	48	0.061
positive regulation of developmental growth	GO:0048639	62	0.061	Mouse
catabolic process	GO:0009056	409	0.061	Worm
nucleoside phosphate metabolic process	GO:0006753	162	0.059
sarcomere organization	GO:0045214	26	0.059
negative regulation of phosphorus metabolic process	GO:0010563	45	0.059
regulation of glial cell proliferation	GO:0060251	11	0.058
regulation of muscle cell differentiation	GO:0051147	8	0.058	Mouse
endoderm formation	GO:0001706	3	0.058
protein complex assembly	GO:0006461	200	0.057
renal tubule development	GO:0061326	64	0.057
regulation of kinase activity	GO:0043549	53	0.057	Human Fly
morphogenesis of a branching structure	GO:0001763	45	0.057	Mouse Fly
negative regulation of protein metabolic process	GO:0051248	85	0.057
positive regulation of growth	GO:0045927	75	0.056	Mouse
regulation of cellular localization	GO:0060341	136	0.056
myofibril assembly	GO:0030239	36	0.055
muscle cell development	GO:0055001	50	0.055
integrin mediated signaling pathway	GO:0007229	3	0.055
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.055	Human Mouse Rat
muscle organ morphogenesis	GO:0048644	7	0.055	Mouse
response to radiation	GO:0009314	155	0.055
cell substrate adhesion	GO:0031589	10	0.055
garland nephrocyte differentiation	GO:0061321	3	0.055
regulation of nucleotide metabolic process	GO:0006140	62	0.054
lymph gland development	GO:0048542	28	0.054
sensory perception of sound	GO:0007605	56	0.054	Mouse
stem cell division	GO:0017145	69	0.054	Mouse
reproductive behavior	GO:0019098	122	0.053	Worm
circulatory system process	GO:0003013	37	0.053
negative regulation of kinase activity	GO:0033673	16	0.053
negative regulation of cellular biosynthetic process	GO:0031327	277	0.053	Mouse
peptidyl tyrosine phosphorylation	GO:0018108	24	0.053	Human Zebrafish Mouse Rat Fly
cognition	GO:0050890	141	0.053
positive regulation of gene expression	GO:0010628	290	0.053	Mouse Rat
positive regulation of cellular protein metabolic process	GO:0032270	118	0.052	Human Mouse Fly
eggshell formation	GO:0030703	105	0.052
protein localization	GO:0008104	284	0.052
negative regulation of protein modification process	GO:0031400	29	0.050
mapk cascade	GO:0000165	107	0.050	Human Mouse Rat Fly
positive regulation of rna biosynthetic process	GO:1902680	266	0.050	Mouse Rat
hematopoietic or lymphoid organ development	GO:0048534	57	0.050
cyclic nucleotide metabolic process	GO:0009187	28	0.050
muscle cell fate commitment	GO:0042693	14	0.049
cellular response to organic substance	GO:0071310	132	0.049	Human Zebrafish Mouse Rat Worm
cation transmembrane transport	GO:0098655	88	0.049
sensory organ morphogenesis	GO:0090596	260	0.049	Mouse
cellular homeostasis	GO:0019725	80	0.049
malpighian tubule morphogenesis	GO:0007443	44	0.049
telencephalon development	GO:0021537	2	0.049	Rat
transmission of nerve impulse	GO:0019226	12	0.049	Mouse
metal ion transport	GO:0030001	74	0.048
open tracheal system development	GO:0007424	204	0.048	Fly
guanosine containing compound metabolic process	GO:1901068	74	0.048
muscle system process	GO:0003012	21	0.047
cell cell junction organization	GO:0045216	55	0.047
embryonic axis specification	GO:0000578	107	0.047
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.047
internal protein amino acid acetylation	GO:0006475	38	0.047
hemocyte migration	GO:0035099	19	0.047
torso signaling pathway	GO:0008293	21	0.047
sensory perception	GO:0007600	196	0.046	Mouse Rat
regulation of notch signaling pathway	GO:0008593	100	0.046
hindgut development	GO:0061525	58	0.046
regulation of lipid metabolic process	GO:0019216	15	0.046	Human Mouse
cellular response to nitrogen compound	GO:1901699	51	0.046
tripartite regional subdivision	GO:0007351	103	0.046
neuron death	GO:0070997	27	0.046	Mouse
multicellular organismal homeostasis	GO:0048871	41	0.046
muscle cell migration	GO:0014812	3	0.045
optokinetic behavior	GO:0007634	3	0.045
negative regulation of growth	GO:0045926	84	0.045	Mouse Fly
hindgut morphogenesis	GO:0007442	58	0.045
negative regulation of cellular protein metabolic process	GO:0032269	85	0.045
regulation of transmembrane transporter activity	GO:0022898	6	0.044
filopodium assembly	GO:0046847	33	0.044	Fly
anterior posterior pattern specification imaginal disc	GO:0007448	16	0.044
response to other organism	GO:0051707	293	0.044
regulation of nucleotide catabolic process	GO:0030811	48	0.044
positive regulation of rna metabolic process	GO:0051254	271	0.043	Mouse Rat
regulation of synaptic transmission	GO:0050804	69	0.043
regulation of proteolysis	GO:0030162	87	0.043	Human
fusion cell fate specification	GO:0035156	4	0.043
regulation of chemotaxis	GO:0050920	12	0.043
erbb signaling pathway	GO:0038127	58	0.043
eye antennal disc development	GO:0035214	60	0.042
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.042
cell growth	GO:0016049	108	0.042	Fly
anterior malpighian tubule development	GO:0061327	12	0.042
regulation of nucleotide biosynthetic process	GO:0030808	14	0.042
response to nitrogen compound	GO:1901698	90	0.041
heart contraction	GO:0060047	26	0.041
regulation of cell adhesion	GO:0030155	27	0.041
negative regulation of cell communication	GO:0010648	223	0.040	Mouse
positive regulation of nucleotide metabolic process	GO:0045981	55	0.040
regulation of actin polymerization or depolymerization	GO:0008064	27	0.040
negative regulation of epidermal growth factor receptor signaling pathway	GO:0042059	29	0.040
neural precursor cell proliferation	GO:0061351	75	0.040	Zebrafish Mouse
optic lobe placode formation	GO:0001744	4	0.040
axon midline choice point recognition	GO:0016199	26	0.040
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.039
covalent chromatin modification	GO:0016569	106	0.039
extrinsic apoptotic signaling pathway	GO:0097191	1	0.039	Human Mouse
regulation of organelle organization	GO:0033043	196	0.039	Mouse
cellular response to fibroblast growth factor stimulus	GO:0044344	10	0.039	Human Zebrafish Mouse Rat Worm
response to light stimulus	GO:0009416	124	0.038
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.038	Mouse
multicellular organismal signaling	GO:0035637	12	0.038	Mouse
exocrine system development	GO:0035272	162	0.038	Mouse
striated muscle cell development	GO:0055002	50	0.038
nephron tubule morphogenesis	GO:0072078	3	0.038
apposition of dorsal and ventral imaginal disc derived wing surfaces	GO:0007475	15	0.037
purine ribonucleoside catabolic process	GO:0046130	112	0.037

htl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of cellular proliferation	DOID:14566	0.292	Human
seminoma	DOID:4440	0.292	Human
germ cell cancer	DOID:2994	0.292	Human
cancer	DOID:162	0.292	Human
cell type cancer	DOID:0050687	0.292	Human
disease of anatomical entity	DOID:7	0.184	Human
heart disease	DOID:114	0.095
tetralogy of fallot	DOID:6419	0.095
cardiovascular system disease	DOID:1287	0.095	Human
congenital heart disease	DOID:1682	0.095

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