IMP: Integrative Multi-species Prediction

Drosophila melanogaster

0 known processes

pes (Dmel_CG7228)

peste

(Aliases: CG7228,Dmel\CG7228,Pes)

Entrez: 34087
FLYBASE: FBgn0031969
UniProtKB: B7Z031
UniProtKB: M9PCW1

Process Predictions
Disease Predictions

pes biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
post embryonic appendage morphogenesis	GO:0035120	385	0.247
single organism biosynthetic process	GO:0044711	206	0.202	Rat Fly
organic acid metabolic process	GO:0006082	103	0.187
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.168
ion transmembrane transport	GO:0034220	122	0.142
lipid metabolic process	GO:0006629	121	0.122	Rat Fly
organonitrogen compound metabolic process	GO:1901564	318	0.121
wing disc morphogenesis	GO:0007472	344	0.116
oxoacid metabolic process	GO:0043436	103	0.107
carboxylic acid metabolic process	GO:0019752	92	0.104
imaginal disc derived appendage development	GO:0048737	399	0.094
imaginal disc derived wing morphogenesis	GO:0007476	337	0.091
appendage development	GO:0048736	401	0.088
negative regulation of cell communication	GO:0010648	223	0.083
regulation of response to stress	GO:0080134	200	0.077	Human
anion transport	GO:0006820	41	0.075
imaginal disc derived leg morphogenesis	GO:0007480	80	0.073
phosphorylation	GO:0016310	294	0.073
actin filament organization	GO:0007015	126	0.072
regulation of cellular ketone metabolic process	GO:0010565	3	0.071
endocytosis	GO:0006897	310	0.066	Human Rat Fly
regulation of localization	GO:0032879	275	0.065	Human Rat
small molecule metabolic process	GO:0044281	305	0.065
transmembrane transport	GO:0055085	139	0.065
regulation of protein metabolic process	GO:0051246	256	0.061
regulation of transport	GO:0051049	181	0.060	Rat
appendage morphogenesis	GO:0035107	397	0.060
leg disc development	GO:0035218	92	0.058
cell death	GO:0008219	279	0.057	Fly
regulation of actin filament based process	GO:0032970	42	0.057
ion transport	GO:0006811	145	0.054
actin cytoskeleton organization	GO:0030036	206	0.050
vesicle mediated transport	GO:0016192	381	0.050	Human Rat Fly
cellular amino acid metabolic process	GO:0006520	61	0.048
organonitrogen compound biosynthetic process	GO:1901566	117	0.047
regionalization	GO:0003002	416	0.046
actin filament based process	GO:0030029	220	0.045
negative regulation of response to stimulus	GO:0048585	258	0.045
catabolic process	GO:0009056	409	0.044
cellular protein modification process	GO:0006464	438	0.044
connective tissue development	GO:0061448	3	0.043
inorganic ion transmembrane transport	GO:0098660	73	0.043
purine containing compound metabolic process	GO:0072521	155	0.043
regulation of cytoskeleton organization	GO:0051493	89	0.041
regulation of cell death	GO:0010941	173	0.041
compound eye development	GO:0048749	307	0.040
regulation of cellular amine metabolic process	GO:0033238	3	0.040
organophosphate metabolic process	GO:0019637	195	0.039
positive regulation of endopeptidase activity	GO:0010950	26	0.039
regulation of phosphate metabolic process	GO:0019220	210	0.038
gland morphogenesis	GO:0022612	145	0.037	Fly
leg disc morphogenesis	GO:0007478	80	0.037
protein modification process	GO:0036211	438	0.037
response to alcohol	GO:0097305	95	0.035
compound eye photoreceptor cell differentiation	GO:0001751	140	0.035
lateral inhibition	GO:0046331	206	0.035
positive regulation of cysteine type endopeptidase activity	GO:2001056	24	0.035
stress activated mapk cascade	GO:0051403	52	0.035
cellular catabolic process	GO:0044248	372	0.034
salivary gland development	GO:0007431	162	0.034	Fly
purine nucleotide metabolic process	GO:0006163	146	0.034
positive regulation of response to stimulus	GO:0048584	323	0.034	Human
homeostatic process	GO:0042592	199	0.033
organic substance transport	GO:0071702	257	0.033	Human Rat Fly
monocarboxylic acid transport	GO:0015718	3	0.033
chemical homeostasis	GO:0048878	92	0.032
regulation of intracellular signal transduction	GO:1902531	236	0.032
regulation of anatomical structure size	GO:0090066	163	0.031
positive regulation of macromolecule metabolic process	GO:0010604	405	0.030
regulation of cell cycle	GO:0051726	291	0.030
cellular amine metabolic process	GO:0044106	12	0.030
apoptotic process	GO:0006915	159	0.030	Fly
organic substance catabolic process	GO:1901575	308	0.030
regulation of defense response	GO:0031347	102	0.029	Human
regulation of catabolic process	GO:0009894	170	0.029
negative regulation of signal transduction	GO:0009968	206	0.029
cellular lipid metabolic process	GO:0044255	83	0.029	Fly
intracellular signal transduction	GO:0035556	300	0.029
sodium dependent phosphate transport	GO:0044341	2	0.029
positive regulation of catabolic process	GO:0009896	105	0.029
cell recognition	GO:0008037	102	0.029	Human Rat
regulation of immune system process	GO:0002682	176	0.029	Human
jnk cascade	GO:0007254	50	0.029
positive regulation of rho gtpase activity	GO:0032321	19	0.029
nucleobase containing small molecule metabolic process	GO:0055086	174	0.028
chromatin organization	GO:0006325	207	0.028
small molecule biosynthetic process	GO:0044283	37	0.028
regulation of mapk cascade	GO:0043408	92	0.028
regulation of immune response	GO:0050776	118	0.027	Human
carbohydrate derivative metabolic process	GO:1901135	217	0.026
regulation of phosphorus metabolic process	GO:0051174	210	0.026
nucleoside metabolic process	GO:0009116	127	0.026
phosphate ion transport	GO:0006817	4	0.026
response to radiation	GO:0009314	155	0.026	Fly
monovalent inorganic cation transport	GO:0015672	40	0.026
response to light stimulus	GO:0009416	124	0.025	Fly
single organism catabolic process	GO:0044712	228	0.025
glycosyl compound metabolic process	GO:1901657	127	0.024
regulation of actin cytoskeleton organization	GO:0032956	42	0.024
eye photoreceptor cell differentiation	GO:0001754	145	0.024
exocrine system development	GO:0035272	162	0.024	Fly
negative regulation of signaling	GO:0023057	219	0.023
response to organic substance	GO:0010033	284	0.023	Human
positive regulation of transport	GO:0051050	92	0.023
regulation of molecular function	GO:0065009	217	0.023	Human
regulation of apoptotic process	GO:0042981	130	0.023
regulation of anatomical structure morphogenesis	GO:0022603	242	0.023
purine ribonucleoside metabolic process	GO:0046128	127	0.022
rho protein signal transduction	GO:0007266	14	0.022
cellular response to chemical stimulus	GO:0070887	199	0.022	Human
cellular ketone metabolic process	GO:0042180	24	0.021
developmental programmed cell death	GO:0010623	138	0.021	Fly
peptide metabolic process	GO:0006518	80	0.021
regulation of organelle organization	GO:0033043	196	0.021
purine ribonucleotide metabolic process	GO:0009150	145	0.021
actin filament bundle organization	GO:0061572	28	0.021
peptidyl amino acid modification	GO:0018193	105	0.021
salivary gland morphogenesis	GO:0007435	145	0.021	Fly
positive regulation of cellular catabolic process	GO:0031331	95	0.021
regulation of cell cycle process	GO:0010564	181	0.020
death	GO:0016265	284	0.020	Fly
regulation of cellular protein metabolic process	GO:0032268	243	0.020
programmed cell death	GO:0012501	257	0.020	Fly
synaptic transmission	GO:0007268	288	0.020
nitrogen compound transport	GO:0071705	85	0.020
positive regulation of programmed cell death	GO:0043068	62	0.020
organic acid transport	GO:0015849	18	0.019
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.019
response to oxygen containing compound	GO:1901700	200	0.019	Human
positive regulation of cell communication	GO:0010647	250	0.019
positive regulation of signaling	GO:0023056	243	0.019
immune system process	GO:0002376	347	0.019	Human Fly
carbohydrate derivative catabolic process	GO:1901136	118	0.019
cellular macromolecule localization	GO:0070727	220	0.019
amine metabolic process	GO:0009308	12	0.019
notch signaling pathway	GO:0007219	120	0.019
negative regulation of phosphorus metabolic process	GO:0010563	45	0.019
stress activated protein kinase signaling cascade	GO:0031098	55	0.018
regulation of multicellular organismal development	GO:2000026	414	0.018
response to biotic stimulus	GO:0009607	294	0.018	Human
protein phosphorylation	GO:0006468	169	0.018
regulation of stress activated mapk cascade	GO:0032872	41	0.018
positive regulation of peptidase activity	GO:0010952	29	0.018
mapk cascade	GO:0000165	107	0.018
positive regulation of molecular function	GO:0044093	136	0.018	Human
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.017
centrosome organization	GO:0051297	163	0.017
response to hexose	GO:0009746	3	0.017
signal transduction by phosphorylation	GO:0023014	107	0.017
eye morphogenesis	GO:0048592	260	0.017
sulfur compound metabolic process	GO:0006790	59	0.017
response to external biotic stimulus	GO:0043207	293	0.017	Human
inorganic cation transmembrane transport	GO:0098662	61	0.017
negative regulation of cellular metabolic process	GO:0031324	382	0.017
gland development	GO:0048732	191	0.017	Fly
response to other organism	GO:0051707	293	0.017	Human
dorsal ventral pattern formation	GO:0009953	133	0.017
regulation of cell proliferation	GO:0042127	163	0.017
synaptic target recognition	GO:0008039	45	0.017
skin development	GO:0043588	65	0.017
nucleotide metabolic process	GO:0009117	161	0.017
ribonucleotide metabolic process	GO:0009259	145	0.017
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.017
morphogenesis of an epithelium	GO:0002009	276	0.016
positive regulation of hydrolase activity	GO:0051345	78	0.016
negative regulation of wnt signaling pathway	GO:0030178	28	0.016
positive regulation of signal transduction	GO:0009967	223	0.016
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.016
response to abiotic stimulus	GO:0009628	341	0.016	Fly
segmentation	GO:0035282	207	0.016
regulation of hydrolase activity	GO:0051336	97	0.016
positive regulation of cellular component organization	GO:0051130	156	0.016
regulation of programmed cell death	GO:0043067	152	0.016
regulation of notch signaling pathway	GO:0008593	100	0.016
cell motility	GO:0048870	251	0.016
regulation of catalytic activity	GO:0050790	185	0.015	Human
regulation of cellular response to stress	GO:0080135	89	0.015
nucleoside triphosphate catabolic process	GO:0009143	108	0.015
regulation of mitotic cell cycle	GO:0007346	190	0.015
negative regulation of growth	GO:0045926	84	0.015
positive regulation of purine nucleotide metabolic process	GO:1900544	55	0.015
centrosome duplication	GO:0051298	121	0.015
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.015
negative regulation of intracellular signal transduction	GO:1902532	57	0.015
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.015
positive regulation of catalytic activity	GO:0043085	118	0.015	Human
phagocytosis	GO:0006909	215	0.015	Human Rat Fly
regulation of jnk cascade	GO:0046328	40	0.015
regulation of phosphorylation	GO:0042325	147	0.015
actin filament bundle assembly	GO:0051017	26	0.015
regulation of growth	GO:0040008	233	0.015
positive regulation of cellular protein metabolic process	GO:0032270	118	0.014
lipid modification	GO:0030258	24	0.014
regulation of peptidase activity	GO:0052547	39	0.014
ras protein signal transduction	GO:0007265	88	0.014
regulation of cell development	GO:0060284	215	0.014
anion homeostasis	GO:0055081	3	0.014
nucleotide catabolic process	GO:0009166	109	0.014
defense response to other organism	GO:0098542	225	0.014
compound eye morphogenesis	GO:0001745	249	0.014
positive regulation of apoptotic process	GO:0043065	47	0.014
mesenchymal cell differentiation	GO:0048762	1	0.014
cell division	GO:0051301	248	0.014
cell proliferation	GO:0008283	299	0.014
epithelium migration	GO:0090132	148	0.014
eye development	GO:0001654	323	0.014
ribose phosphate metabolic process	GO:0019693	145	0.014
negative regulation of phosphate metabolic process	GO:0045936	45	0.014
positive regulation of cell death	GO:0010942	69	0.013
neuron fate commitment	GO:0048663	50	0.013
salivary gland histolysis	GO:0035070	88	0.013	Fly
negative regulation of phosphorylation	GO:0042326	35	0.013
glycosyl compound catabolic process	GO:1901658	112	0.013
positive regulation of multicellular organismal process	GO:0051240	143	0.013
regulation of epithelial cell differentiation	GO:0030856	4	0.013
negative regulation of protein metabolic process	GO:0051248	85	0.013
regulation of cell differentiation	GO:0045595	302	0.013
organonitrogen compound catabolic process	GO:1901565	128	0.013
tissue death	GO:0016271	102	0.013	Fly
nucleoside phosphate metabolic process	GO:0006753	162	0.013
sensory organ morphogenesis	GO:0090596	260	0.013
autophagy	GO:0006914	108	0.013
cellular response to starvation	GO:0009267	61	0.013
regulation of protein localization	GO:0032880	76	0.013
cell growth	GO:0016049	108	0.012
body morphogenesis	GO:0010171	2	0.012
monocarboxylic acid metabolic process	GO:0032787	29	0.012
nucleobase containing compound catabolic process	GO:0034655	165	0.012
microtubule organizing center organization	GO:0031023	168	0.012
chromatin modification	GO:0016568	147	0.012
ribonucleoside metabolic process	GO:0009119	127	0.012
developmental growth	GO:0048589	280	0.012
organic anion transport	GO:0015711	28	0.012
membrane organization	GO:0061024	112	0.012
small gtpase mediated signal transduction	GO:0007264	88	0.012
defense response to gram negative bacterium	GO:0050829	94	0.012
positive regulation of cellular biosynthetic process	GO:0031328	316	0.012
negative regulation of cell proliferation	GO:0008285	69	0.012
single organism intracellular transport	GO:1902582	207	0.012
embryonic morphogenesis	GO:0048598	206	0.012
neuron recognition	GO:0008038	101	0.012
hindgut development	GO:0061525	58	0.012
ribonucleoside catabolic process	GO:0042454	112	0.012
regulation of cellular component size	GO:0032535	98	0.012
myotube cell development	GO:0014904	3	0.012
neurological system process	GO:0050877	358	0.012
protein localization	GO:0008104	284	0.012
eye photoreceptor cell fate commitment	GO:0042706	37	0.012
negative regulation of cellular biosynthetic process	GO:0031327	277	0.012
intracellular transport	GO:0046907	228	0.012
cellular homeostasis	GO:0019725	80	0.011
cellular modified amino acid metabolic process	GO:0006575	45	0.011
histolysis	GO:0007559	102	0.011	Fly
response to ethanol	GO:0045471	59	0.011
positive regulation of proteolysis	GO:0045862	52	0.011
localization of cell	GO:0051674	257	0.011
positive regulation of phosphorus metabolic process	GO:0010562	139	0.011
one carbon metabolic process	GO:0006730	3	0.011
response to bacterium	GO:0009617	198	0.011	Human
organelle localization	GO:0051640	148	0.011
sterol homeostasis	GO:0055092	4	0.011
lipid storage	GO:0019915	38	0.011	Human
embryonic development via the syncytial blastoderm	GO:0001700	148	0.011
gtp catabolic process	GO:0006184	72	0.011
regulation of gtp catabolic process	GO:0033124	44	0.011
nucleoside phosphate catabolic process	GO:1901292	110	0.011
chaeta development	GO:0022416	97	0.011
innate immune response	GO:0045087	144	0.011
cellular response to dna damage stimulus	GO:0006974	223	0.011
regulation of cellular localization	GO:0060341	136	0.011
ameboidal type cell migration	GO:0001667	151	0.011
muscle structure development	GO:0061061	224	0.011
regulation of proteolysis	GO:0030162	87	0.011
wing disc pattern formation	GO:0035222	66	0.011
positive regulation of phosphate metabolic process	GO:0045937	139	0.011
positive regulation of lipid metabolic process	GO:0045834	4	0.011
male gamete generation	GO:0048232	201	0.011
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.011
negative regulation of developmental process	GO:0051093	201	0.011
negative regulation of cellular protein metabolic process	GO:0032269	85	0.011
fatty acid metabolic process	GO:0006631	20	0.011
compound eye photoreceptor fate commitment	GO:0001752	36	0.011
single organism behavior	GO:0044708	391	0.010
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.010
nuclear division	GO:0000280	332	0.010
cellular response to molecule of bacterial origin	GO:0071219	3	0.010	Human
protein transport	GO:0015031	155	0.010
lipid localization	GO:0010876	54	0.010	Human Rat Fly
purine nucleoside catabolic process	GO:0006152	112	0.010
proteolysis	GO:0006508	192	0.010
cation transmembrane transport	GO:0098655	88	0.010
aromatic compound catabolic process	GO:0019439	166	0.010
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.010
hindgut morphogenesis	GO:0007442	58	0.010
glycerolipid metabolic process	GO:0046486	34	0.010
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.010
extrinsic apoptotic signaling pathway	GO:0097191	1	0.010

pes disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.027
sensory system disease	DOID:0050155	0.015
nervous system disease	DOID:863	0.015
disease of cellular proliferation	DOID:14566	0.011
organ system cancer	DOID:0050686	0.011
cancer	DOID:162	0.011
eye disease	DOID:5614	0.011
eye and adnexa disease	DOID:1492	0.011

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