IMP: Integrative Multi-species Prediction

Drosophila melanogaster

88 known processes

Nacalpha (Dmel_CG8759)

Nascent polypeptide associated complex protein alpha subunit

(Aliases: alpha-NAC,NAC,NACalpha,alphaNAC,l(2)04329,Dmel\CG8759,CG8759,aic)

Entrez: 36409
FLYBASE: FBgn0086904
UniProtKB: Q94518

Process Predictions
Disease Predictions

Nacalpha biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
proteolysis	GO:0006508	192	0.593
regulation of localization	GO:0032879	275	0.477
macromolecular complex assembly	GO:0065003	256	0.369
dendrite development	GO:0016358	204	0.340
positive regulation of biosynthetic process	GO:0009891	316	0.329	Mouse
regulation of embryonic development	GO:0045995	68	0.291
positive regulation of response to stimulus	GO:0048584	323	0.256
response to abiotic stimulus	GO:0009628	341	0.247
single organism catabolic process	GO:0044712	228	0.223
regulation of multicellular organismal development	GO:2000026	414	0.216
regulation of embryonic pattern specification	GO:1902875	27	0.205
regulation of translation	GO:0006417	56	0.200
regulation of cell differentiation	GO:0045595	302	0.195
protein complex biogenesis	GO:0070271	201	0.192
death	GO:0016265	284	0.190	Mouse
translation	GO:0006412	69	0.178
positive regulation of cell communication	GO:0010647	250	0.173
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.156	Mouse
brain development	GO:0007420	120	0.145
regulation of cell death	GO:0010941	173	0.140	Mouse
intracellular transport	GO:0046907	228	0.138
body morphogenesis	GO:0010171	2	0.136	Worm
regulation of cellular ketone metabolic process	GO:0010565	3	0.135
head development	GO:0060322	135	0.126
positive regulation of developmental process	GO:0051094	143	0.123	Mouse
organophosphate metabolic process	GO:0019637	195	0.121
positive regulation of signaling	GO:0023056	243	0.120
cell proliferation	GO:0008283	299	0.115	Mouse
imaginal disc derived wing morphogenesis	GO:0007476	337	0.115
vesicle mediated transport	GO:0016192	381	0.111
positive regulation of multicellular organismal process	GO:0051240	143	0.109	Mouse
small molecule metabolic process	GO:0044281	305	0.109
purine ribonucleotide catabolic process	GO:0009154	109	0.107
regulation of cellular component biogenesis	GO:0044087	201	0.105
dendrite morphogenesis	GO:0048813	199	0.105
carboxylic acid metabolic process	GO:0019752	92	0.097
programmed cell death	GO:0012501	257	0.097	Mouse
regulation of oocyte development	GO:0060281	27	0.095
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.095	Mouse
positive regulation of gene expression	GO:0010628	290	0.093	Mouse
intracellular signal transduction	GO:0035556	300	0.088
regulation of neurogenesis	GO:0050767	158	0.086
axon development	GO:0061564	297	0.084
organic substance catabolic process	GO:1901575	308	0.083
cellular ketone metabolic process	GO:0042180	24	0.081
cell death	GO:0008219	279	0.081	Mouse
positive regulation of cellular biosynthetic process	GO:0031328	316	0.081	Mouse
regulation of cellular localization	GO:0060341	136	0.079
regulation of protein metabolic process	GO:0051246	256	0.075
regulation of mrna splicing via spliceosome	GO:0048024	64	0.074
purine nucleoside catabolic process	GO:0006152	112	0.072
cellular catabolic process	GO:0044248	372	0.072
nucleotide metabolic process	GO:0009117	161	0.071
regulation of apoptotic process	GO:0042981	130	0.070	Mouse
negative regulation of gene expression	GO:0010629	387	0.068	Mouse
apoptotic process	GO:0006915	159	0.065	Mouse
positive regulation of signal transduction	GO:0009967	223	0.063
nucleotide catabolic process	GO:0009166	109	0.063
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.062	Mouse
organonitrogen compound metabolic process	GO:1901564	318	0.062
translational initiation	GO:0006413	11	0.061
appendage morphogenesis	GO:0035107	397	0.060
regulation of transport	GO:0051049	181	0.060
negative regulation of cellular metabolic process	GO:0031324	382	0.059	Mouse
protein localization	GO:0008104	284	0.058
rna localization	GO:0006403	115	0.057
cytoplasmic transport	GO:0016482	130	0.056
endocytosis	GO:0006897	310	0.055
tissue morphogenesis	GO:0048729	297	0.055
reproductive structure development	GO:0048608	74	0.054	Worm
dna metabolic process	GO:0006259	227	0.054
glycosyl compound metabolic process	GO:1901657	127	0.053
organelle assembly	GO:0070925	198	0.052	Zebrafish
purine ribonucleoside metabolic process	GO:0046128	127	0.051
cellular protein localization	GO:0034613	160	0.051
ribose phosphate metabolic process	GO:0019693	145	0.051
establishment of protein localization	GO:0045184	163	0.051
pole plasm mrna localization	GO:0019094	49	0.049
nuclear division	GO:0000280	332	0.049	Worm
positive regulation of macromolecule metabolic process	GO:0010604	405	0.048	Mouse
organic substance transport	GO:0071702	257	0.048
posttranscriptional regulation of gene expression	GO:0010608	145	0.047
carbohydrate derivative catabolic process	GO:1901136	118	0.046
tube morphogenesis	GO:0035239	191	0.046
carbohydrate derivative metabolic process	GO:1901135	217	0.046
post embryonic appendage morphogenesis	GO:0035120	385	0.046
rna splicing via transesterification reactions	GO:0000375	73	0.045
purine nucleotide metabolic process	GO:0006163	146	0.044
histolysis	GO:0007559	102	0.044
protein dna complex subunit organization	GO:0071824	86	0.043
response to temperature stimulus	GO:0009266	106	0.043
membrane organization	GO:0061024	112	0.043
central nervous system development	GO:0007417	201	0.043
taxis	GO:0042330	304	0.042
negative regulation of programmed cell death	GO:0043069	72	0.042	Mouse
purine ribonucleoside catabolic process	GO:0046130	112	0.042
purine nucleoside metabolic process	GO:0042278	127	0.041
positive regulation of rna biosynthetic process	GO:1902680	266	0.041	Mouse
single organism carbohydrate metabolic process	GO:0044723	72	0.041
cell adhesion	GO:0007155	136	0.041
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.040	Mouse
purine containing compound catabolic process	GO:0072523	112	0.040
positive regulation of cell proliferation	GO:0008284	47	0.040	Mouse
positive regulation of rna metabolic process	GO:0051254	271	0.038	Mouse
negative regulation of cellular biosynthetic process	GO:0031327	277	0.038	Mouse
positive regulation of protein metabolic process	GO:0051247	128	0.038
protein complex assembly	GO:0006461	200	0.038
gland morphogenesis	GO:0022612	145	0.037
negative regulation of biosynthetic process	GO:0009890	277	0.037	Mouse
axonogenesis	GO:0007409	290	0.036
negative regulation of rna metabolic process	GO:0051253	251	0.035	Mouse
cellular lipid metabolic process	GO:0044255	83	0.035
cellular macromolecule localization	GO:0070727	220	0.034
neurological system process	GO:0050877	358	0.034
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.034
organic cyclic compound catabolic process	GO:1901361	168	0.034
tube development	GO:0035295	244	0.033
tissue death	GO:0016271	102	0.033
regulation of cell proliferation	GO:0042127	163	0.033	Mouse
regionalization	GO:0003002	416	0.032
exocrine system development	GO:0035272	162	0.032
purine containing compound metabolic process	GO:0072521	155	0.032
salivary gland development	GO:0007431	162	0.032
protein targeting	GO:0006605	64	0.032
intracellular mrna localization involved in anterior posterior axis specification	GO:0060811	53	0.031
phagocytosis	GO:0006909	215	0.031
regulation of programmed cell death	GO:0043067	152	0.031	Mouse
regulation of molecular function	GO:0065009	217	0.031
oxoacid metabolic process	GO:0043436	103	0.031
reproductive system development	GO:0061458	74	0.031	Worm
gliogenesis	GO:0042063	80	0.030
rna processing	GO:0006396	147	0.030
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.030
regulation of cellular catabolic process	GO:0031329	157	0.029
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.029
protein transport	GO:0015031	155	0.029
negative regulation of developmental process	GO:0051093	201	0.029
catabolic process	GO:0009056	409	0.029
glycosyl compound catabolic process	GO:1901658	112	0.028
regulation of rna splicing	GO:0043484	69	0.028
regulation of intracellular signal transduction	GO:1902531	236	0.028
heterocycle catabolic process	GO:0046700	166	0.028
actin filament based process	GO:0030029	220	0.028	Zebrafish
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.027
organophosphate catabolic process	GO:0046434	112	0.027
single organism cellular localization	GO:1902580	180	0.027
nucleoside catabolic process	GO:0009164	112	0.027
salivary gland cell autophagic cell death	GO:0035071	83	0.026
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.026
intracellular receptor signaling pathway	GO:0030522	19	0.026
morphogenesis of an epithelium	GO:0002009	276	0.026
nucleoside phosphate metabolic process	GO:0006753	162	0.026
salivary gland histolysis	GO:0035070	88	0.026
organelle fission	GO:0048285	340	0.025	Worm
cell redox homeostasis	GO:0045454	5	0.025
salivary gland morphogenesis	GO:0007435	145	0.025
determination of adult lifespan	GO:0008340	137	0.025	Worm
regulation of cell maturation	GO:1903429	27	0.025
nucleobase containing small molecule metabolic process	GO:0055086	174	0.024
mitotic spindle organization	GO:0007052	220	0.024
establishment of localization in cell	GO:0051649	402	0.024
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	73	0.024
appendage development	GO:0048736	401	0.024
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.023
regulation of cellular protein metabolic process	GO:0032268	243	0.023
imaginal disc derived appendage development	GO:0048737	399	0.023
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.023
protein processing	GO:0016485	68	0.023
negative regulation of signaling	GO:0023057	219	0.022
positive regulation of intracellular signal transduction	GO:1902533	116	0.022
regulation of phosphorus metabolic process	GO:0051174	210	0.022
regulation of pole plasm oskar mrna localization	GO:0007317	27	0.022
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.022	Mouse
establishment or maintenance of cell polarity	GO:0007163	167	0.022
regulation of cellular amine metabolic process	GO:0033238	3	0.021
homeostatic process	GO:0042592	199	0.021
biological adhesion	GO:0022610	138	0.021
mrna splicing via spliceosome	GO:0000398	73	0.021
response to starvation	GO:0042594	97	0.021
positive regulation of phosphate metabolic process	GO:0045937	139	0.020
retinal metabolic process	GO:0042574	2	0.020
regulation of mrna processing	GO:0050684	71	0.020
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.020	Mouse
oxidation reduction process	GO:0055114	123	0.020
immune response	GO:0006955	246	0.020
positive regulation of immune system process	GO:0002684	68	0.019
autophagic cell death	GO:0048102	83	0.019
spindle assembly involved in mitosis	GO:0090307	50	0.019
wing disc morphogenesis	GO:0007472	344	0.019
regulation of cellular amino acid metabolic process	GO:0006521	0	0.019
maintenance of location	GO:0051235	73	0.019	Worm
striated muscle myosin thick filament assembly	GO:0071688	3	0.019
immune system process	GO:0002376	347	0.019
nucleosome organization	GO:0034728	59	0.019
positive regulation of cellular protein metabolic process	GO:0032270	118	0.019
positive regulation of transport	GO:0051050	92	0.019
gland development	GO:0048732	191	0.019
positive regulation of phosphorylation	GO:0042327	87	0.018
cellular homeostasis	GO:0019725	80	0.018
negative regulation of transcription dna templated	GO:0045892	237	0.018	Mouse
protein maturation	GO:0051604	71	0.018
regulation of response to stress	GO:0080134	200	0.018
response to extracellular stimulus	GO:0009991	116	0.018
nucleoside triphosphate catabolic process	GO:0009143	108	0.018
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.018
regulation of proteolysis	GO:0030162	87	0.018
negative regulation of response to stimulus	GO:0048585	258	0.018
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.018
lipid metabolic process	GO:0006629	121	0.017
negative regulation of signal transduction	GO:0009968	206	0.017
cell aging	GO:0007569	2	0.017
notch signaling pathway	GO:0007219	120	0.017
purine ribonucleotide metabolic process	GO:0009150	145	0.017
intracellular mrna localization	GO:0008298	66	0.017
cellular amine metabolic process	GO:0044106	12	0.017
dorsal ventral pattern formation	GO:0009953	133	0.017
rrna processing	GO:0006364	3	0.016
protein modification by small protein conjugation	GO:0032446	79	0.016
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.016
regulation of cell development	GO:0060284	215	0.016
regulation of protein modification process	GO:0031399	112	0.016
response to bacterium	GO:0009617	198	0.016
intracellular mrna localization involved in pattern specification process	GO:0060810	56	0.016
response to other organism	GO:0051707	293	0.016
organic acid metabolic process	GO:0006082	103	0.016
multicellular organismal aging	GO:0010259	140	0.016	Worm
regulation of purine nucleotide metabolic process	GO:1900542	62	0.015
nucleobase containing compound catabolic process	GO:0034655	165	0.015
cardiovascular system development	GO:0072358	82	0.015	Mouse
positive regulation of neurogenesis	GO:0050769	41	0.015
nucleoside metabolic process	GO:0009116	127	0.015
response to external biotic stimulus	GO:0043207	293	0.015
lipid storage	GO:0019915	38	0.015	Worm
negative regulation of cell communication	GO:0010648	223	0.015
carbohydrate metabolic process	GO:0005975	82	0.015
cellular response to dna damage stimulus	GO:0006974	223	0.014
ribonucleoside metabolic process	GO:0009119	127	0.014
response to nutrient levels	GO:0031667	114	0.014
generation of precursor metabolites and energy	GO:0006091	42	0.014
larval development	GO:0002164	104	0.014	Worm
positive regulation of ion transmembrane transporter activity	GO:0032414	4	0.014
glial cell proliferation	GO:0014009	13	0.014
chromatin organization	GO:0006325	207	0.014
nucleocytoplasmic transport	GO:0006913	72	0.014
cell cycle checkpoint	GO:0000075	95	0.014
mitotic nuclear division	GO:0007067	213	0.014
negative regulation of molecular function	GO:0044092	51	0.013
regulation of phosphate metabolic process	GO:0019220	210	0.013
cellular macromolecular complex assembly	GO:0034622	153	0.013
establishment of protein localization to organelle	GO:0072594	62	0.013
response to biotic stimulus	GO:0009607	294	0.013
regulation of mitotic cell cycle	GO:0007346	190	0.013
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.013	Mouse
aromatic compound catabolic process	GO:0019439	166	0.013
negative regulation of cell death	GO:0060548	81	0.013	Mouse
jak stat cascade	GO:0007259	49	0.013
muscle structure development	GO:0061061	224	0.013	Zebrafish Mouse
spindle organization	GO:0007051	253	0.013
purine nucleotide catabolic process	GO:0006195	109	0.013
neuron projection guidance	GO:0097485	241	0.013
regulation of catabolic process	GO:0009894	170	0.013
fluid transport	GO:0042044	19	0.012
intracellular protein transport	GO:0006886	104	0.012
regulation of transmembrane transporter activity	GO:0022898	6	0.012
regulation of nervous system development	GO:0051960	248	0.012
cellular macromolecule catabolic process	GO:0044265	136	0.012
developmental programmed cell death	GO:0010623	138	0.012
circulatory system development	GO:0072359	82	0.012	Mouse
ribonucleoprotein complex assembly	GO:0022618	23	0.012
cellular amino acid metabolic process	GO:0006520	61	0.012
cellular nitrogen compound catabolic process	GO:0044270	165	0.012
amine metabolic process	GO:0009308	12	0.012
tripartite regional subdivision	GO:0007351	103	0.012
regulation of behavior	GO:0050795	75	0.012
negative regulation of cell cycle	GO:0045786	116	0.012
developmental growth	GO:0048589	280	0.012	Mouse
apoptotic signaling pathway	GO:0097190	27	0.012
regulation of catalytic activity	GO:0050790	185	0.012
mrna processing	GO:0006397	104	0.011
protein dna complex assembly	GO:0065004	63	0.011
sesquiterpenoid metabolic process	GO:0006714	3	0.011
stem cell differentiation	GO:0048863	117	0.011
regulation of mrna metabolic process	GO:1903311	72	0.011
atp metabolic process	GO:0046034	49	0.011
mrna metabolic process	GO:0016071	124	0.011
response to water deprivation	GO:0009414	4	0.011
centrosome duplication	GO:0051298	121	0.011
nucleoside monophosphate metabolic process	GO:0009123	52	0.011
multi organism behavior	GO:0051705	175	0.011
ribonucleotide catabolic process	GO:0009261	109	0.011
ribonucleotide metabolic process	GO:0009259	145	0.011
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.011	Mouse
eye development	GO:0001654	323	0.011
stem cell maintenance	GO:0019827	67	0.010
response to decreased oxygen levels	GO:0036293	58	0.010
single organism intracellular transport	GO:1902582	207	0.010
nucleoside triphosphate metabolic process	GO:0009141	120	0.010
growth	GO:0040007	359	0.010	Mouse
oocyte construction	GO:0007308	112	0.010
regulation of neuron differentiation	GO:0045664	103	0.010
negative regulation of apoptotic process	GO:0043066	63	0.010	Mouse
anterior posterior axis specification	GO:0009948	109	0.010

Nacalpha disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
musculoskeletal system disease	DOID:17	0.114
disease of anatomical entity	DOID:7	0.114
muscular disease	DOID:0080000	0.017
muscle tissue disease	DOID:66	0.017

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