IMP: Integrative Multi-species Prediction

Drosophila melanogaster

0 known processes

Aly (Dmel_CG1101)

CG1101 gene product from transcript CG1101-RA

(Aliases: dmREF1,l(3)02267,cg1101,REF1,CG1101,Dmel\CG1101,ref1,BcDNA:LD24793,DmREF1)

Entrez: 44029
FLYBASE: FBgn0010774
UniProtKB: Q9V3E7

Process Predictions
Disease Predictions

Aly biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
cell division	GO:0051301	248	0.893
cell migration	GO:0016477	238	0.642
cell motility	GO:0048870	251	0.628
epithelial cell migration	GO:0010631	148	0.409
nuclear division	GO:0000280	332	0.371
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.360
negative regulation of rna metabolic process	GO:0051253	251	0.299
protein localization	GO:0008104	284	0.290
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.281
negative regulation of signal transduction	GO:0009968	206	0.254
establishment of localization in cell	GO:0051649	402	0.242
cellular protein localization	GO:0034613	160	0.237
negative regulation of cellular metabolic process	GO:0031324	382	0.236
response to radiation	GO:0009314	155	0.229
negative regulation of gene expression	GO:0010629	387	0.223
cytokinesis	GO:0000910	90	0.213
epithelium migration	GO:0090132	148	0.212
reproductive behavior	GO:0019098	122	0.210
regulation of organelle organization	GO:0033043	196	0.200
positive regulation of macromolecule metabolic process	GO:0010604	405	0.195
negative regulation of signaling	GO:0023057	219	0.194
regulation of localization	GO:0032879	275	0.190
cellular response to dna damage stimulus	GO:0006974	223	0.185
tissue migration	GO:0090130	155	0.180
cellular catabolic process	GO:0044248	372	0.176
transcription from rna polymerase ii promoter	GO:0006366	368	0.172
cell proliferation	GO:0008283	299	0.165
death	GO:0016265	284	0.155
negative regulation of cell communication	GO:0010648	223	0.149
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.149
meiotic cell cycle process	GO:1903046	132	0.147
meiotic cell cycle	GO:0051321	171	0.146
intracellular protein transport	GO:0006886	104	0.143
negative regulation of response to stimulus	GO:0048585	258	0.138
regulation of cell cycle	GO:0051726	291	0.137
organelle fission	GO:0048285	340	0.133
cellular macromolecule localization	GO:0070727	220	0.126
single organism intracellular transport	GO:1902582	207	0.125
negative regulation of cellular biosynthetic process	GO:0031327	277	0.123
cellular macromolecule catabolic process	GO:0044265	136	0.119
epithelial cell differentiation	GO:0030855	322	0.117
macromolecule catabolic process	GO:0009057	161	0.115
positive regulation of biosynthetic process	GO:0009891	316	0.115
catabolic process	GO:0009056	409	0.114
localization of cell	GO:0051674	257	0.109
negative regulation of meiotic cell cycle	GO:0051447	2	0.106
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.105
endocytosis	GO:0006897	310	0.104
meiotic nuclear division	GO:0007126	151	0.098
dna integrity checkpoint	GO:0031570	81	0.098
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.097
positive regulation of response to stimulus	GO:0048584	323	0.095
mitotic spindle organization	GO:0007052	220	0.094
single organism behavior	GO:0044708	391	0.092
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.090
regulation of cell cycle process	GO:0010564	181	0.085
regulation of meiosis	GO:0040020	3	0.083
intracellular transport	GO:0046907	228	0.082
dna damage checkpoint	GO:0000077	78	0.081
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.079
multi multicellular organism process	GO:0044706	123	0.079
regulation of cellular amine metabolic process	GO:0033238	3	0.078
reproductive system development	GO:0061458	74	0.078
ameboidal type cell migration	GO:0001667	151	0.076
multi organism behavior	GO:0051705	175	0.076
regulation of intracellular protein transport	GO:0033157	46	0.076
regulation of sister chromatid segregation	GO:0033045	28	0.075
organic substance transport	GO:0071702	257	0.074
proteolysis	GO:0006508	192	0.073
positive regulation of transcription dna templated	GO:0045893	266	0.073
response to light stimulus	GO:0009416	124	0.073
multicellular organismal reproductive behavior	GO:0033057	110	0.072
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.068
phagocytosis	GO:0006909	215	0.068
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.067
epithelial cell development	GO:0002064	274	0.067
regulation of cellular ketone metabolic process	GO:0010565	3	0.067
positive regulation of rna metabolic process	GO:0051254	271	0.067
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.066
regulation of wnt signaling pathway	GO:0030111	68	0.065
negative regulation of biosynthetic process	GO:0009890	277	0.065
single organism cellular localization	GO:1902580	180	0.065
vesicle mediated transport	GO:0016192	381	0.064
protein maturation	GO:0051604	71	0.063
multi organism reproductive behavior	GO:0044705	121	0.062
biological adhesion	GO:0022610	138	0.061
programmed cell death	GO:0012501	257	0.061
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.061
protein processing	GO:0016485	68	0.061
sex differentiation	GO:0007548	81	0.059
negative regulation of catabolic process	GO:0009895	36	0.059
regulation of mitotic cell cycle	GO:0007346	190	0.059
embryo development ending in birth or egg hatching	GO:0009792	152	0.057
neurological system process	GO:0050877	358	0.056
protein modification process	GO:0036211	438	0.056
lateral inhibition	GO:0046331	206	0.056
rna processing	GO:0006396	147	0.055
maintenance of protein location	GO:0045185	28	0.055
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.055
regulation of growth	GO:0040008	233	0.055
regulation of cell cycle phase transition	GO:1901987	130	0.054
cell adhesion	GO:0007155	136	0.054
camera type eye development	GO:0043010	4	0.053
maintenance of protein location in cell	GO:0032507	26	0.053
negative regulation of cell cycle phase transition	GO:1901988	103	0.052
cell death	GO:0008219	279	0.052
cullin deneddylation	GO:0010388	3	0.051
wnt protein secretion	GO:0061355	5	0.051
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.050
cytoskeleton dependent cytokinesis	GO:0061640	81	0.050
protein transport	GO:0015031	155	0.050
regulation of anatomical structure morphogenesis	GO:0022603	242	0.050
growth	GO:0040007	359	0.049
regulation of proteolysis	GO:0030162	87	0.049
single organism catabolic process	GO:0044712	228	0.048
negative regulation of transcription dna templated	GO:0045892	237	0.047
negative regulation of small gtpase mediated signal transduction	GO:0051058	13	0.047
regionalization	GO:0003002	416	0.046
macromolecular complex assembly	GO:0065003	256	0.045
regulation of locomotion	GO:0040012	42	0.044
regulation of programmed cell death	GO:0043067	152	0.044
mitotic cell cycle checkpoint	GO:0007093	88	0.043
compound eye morphogenesis	GO:0001745	249	0.043
appendage development	GO:0048736	401	0.043
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	73	0.042
positive regulation of rna biosynthetic process	GO:1902680	266	0.042
double strand break repair	GO:0006302	26	0.041
chemotaxis	GO:0006935	249	0.041
regulation of phosphorylation	GO:0042325	147	0.040
regulation of anatomical structure size	GO:0090066	163	0.040
negative regulation of cellular protein metabolic process	GO:0032269	85	0.040
protein dna complex subunit organization	GO:0071824	86	0.040
regulation of cellular amino acid metabolic process	GO:0006521	0	0.040
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.040
stem cell proliferation	GO:0072089	88	0.039
cell cycle checkpoint	GO:0000075	95	0.039
regulation of catabolic process	GO:0009894	170	0.039
central nervous system development	GO:0007417	201	0.038
regulation of protein metabolic process	GO:0051246	256	0.038
rna splicing	GO:0008380	83	0.038
nucleosome organization	GO:0034728	59	0.038
spindle organization	GO:0007051	253	0.037
regulation of cellular protein metabolic process	GO:0032268	243	0.037
mrna cis splicing via spliceosome	GO:0045292	1	0.037
immune system process	GO:0002376	347	0.036
compound eye development	GO:0048749	307	0.036
eye development	GO:0001654	323	0.036
synapse assembly	GO:0007416	143	0.036
positive regulation of protein secretion	GO:0050714	9	0.036
proteasomal protein catabolic process	GO:0010498	59	0.035
positive regulation of cell communication	GO:0010647	250	0.035
negative regulation of cell death	GO:0060548	81	0.034
dorsal ventral pattern formation	GO:0009953	133	0.034
negative regulation of cellular component organization	GO:0051129	108	0.034
taxis	GO:0042330	304	0.034
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.034
positive regulation of signaling	GO:0023056	243	0.034
regulation of protein localization	GO:0032880	76	0.034
regulation of response to stress	GO:0080134	200	0.033
reproductive structure development	GO:0048608	74	0.033
mrna splicing via spliceosome	GO:0000398	73	0.033
regulation of protein transport	GO:0051223	57	0.032
positive regulation of cellular protein metabolic process	GO:0032270	118	0.032
regulation of protein complex assembly	GO:0043254	42	0.032
negative regulation of protein metabolic process	GO:0051248	85	0.032
nuclear transport	GO:0051169	72	0.032
regulation of cell morphogenesis	GO:0022604	163	0.031
development of primary sexual characteristics	GO:0045137	50	0.031
cellular macromolecular complex assembly	GO:0034622	153	0.031
negative regulation of proteasomal protein catabolic process	GO:1901799	16	0.031
organic substance catabolic process	GO:1901575	308	0.030
detection of stimulus	GO:0051606	156	0.030
regulation of apoptotic process	GO:0042981	130	0.030
cellular nitrogen compound catabolic process	GO:0044270	165	0.030
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.029
regulation of cellular component biogenesis	GO:0044087	201	0.029
aromatic compound catabolic process	GO:0019439	166	0.029
positive regulation of protein metabolic process	GO:0051247	128	0.029
regulation of mrna splicing via spliceosome	GO:0048024	64	0.029
regulation of protein processing	GO:0070613	32	0.029
regulation of response to external stimulus	GO:0032101	115	0.029
amine metabolic process	GO:0009308	12	0.028
body morphogenesis	GO:0010171	2	0.028
ovarian follicle cell development	GO:0030707	248	0.027
response to abiotic stimulus	GO:0009628	341	0.027
regulation of cell division	GO:0051302	72	0.027
posttranscriptional regulation of gene expression	GO:0010608	145	0.027
wnt signaling pathway	GO:0016055	98	0.027
regulation of transport	GO:0051049	181	0.027
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.027
regulation of establishment of protein localization	GO:0070201	61	0.026
positive regulation of gene expression	GO:0010628	290	0.026
cytoplasmic transport	GO:0016482	130	0.026
regulation of phosphorus metabolic process	GO:0051174	210	0.026
positive regulation of cellular biosynthetic process	GO:0031328	316	0.025
mrna metabolic process	GO:0016071	124	0.024
organonitrogen compound metabolic process	GO:1901564	318	0.024
regulation of molecular function	GO:0065009	217	0.024
negative regulation of intracellular signal transduction	GO:1902532	57	0.024
regulation of multi organism process	GO:0043900	131	0.024
protein complex biogenesis	GO:0070271	201	0.023
axon development	GO:0061564	297	0.023
regulation of intracellular transport	GO:0032386	64	0.023
regulation of vesicle mediated transport	GO:0060627	59	0.023
regulation of alternative mrna splicing via spliceosome	GO:0000381	60	0.022
protein complex assembly	GO:0006461	200	0.022
negative regulation of rna biosynthetic process	GO:1902679	240	0.022
regulation of protein catabolic process	GO:0042176	55	0.022
regulation of cellular localization	GO:0060341	136	0.022
response to external biotic stimulus	GO:0043207	293	0.022
response to nutrient levels	GO:0031667	114	0.022
gliogenesis	GO:0042063	80	0.022
cell cycle phase transition	GO:0044770	140	0.022
secondary metabolic process	GO:0019748	75	0.022
negative regulation of cellular catabolic process	GO:0031330	34	0.022
developmental maturation	GO:0021700	172	0.021
cellular amine metabolic process	GO:0044106	12	0.021
maintenance of location	GO:0051235	73	0.021
phosphorylation	GO:0016310	294	0.021
protein targeting	GO:0006605	64	0.021
chromosome organization	GO:0051276	360	0.021
positive regulation of transport	GO:0051050	92	0.020
mitotic g2 dna damage checkpoint	GO:0007095	69	0.020
detection of stimulus involved in sensory perception	GO:0050906	92	0.020
negative regulation of organelle organization	GO:0010639	56	0.020
neuroblast proliferation	GO:0007405	74	0.020
organelle localization	GO:0051640	148	0.020
chromosome segregation	GO:0007059	157	0.020
dna metabolic process	GO:0006259	227	0.020
nucleobase containing compound catabolic process	GO:0034655	165	0.020
nucleoside phosphate metabolic process	GO:0006753	162	0.020
developmental growth	GO:0048589	280	0.020
chromatin assembly	GO:0031497	48	0.020
axonogenesis	GO:0007409	290	0.020
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.020
establishment of protein localization	GO:0045184	163	0.019
regulation of mrna metabolic process	GO:1903311	72	0.019
regulation of protein modification process	GO:0031399	112	0.019
positive regulation of signal transduction	GO:0009967	223	0.019
chromatin organization	GO:0006325	207	0.019
signal transduction by phosphorylation	GO:0023014	107	0.019
protein catabolic process	GO:0030163	101	0.019
cellular protein modification process	GO:0006464	438	0.019
rna catabolic process	GO:0006401	37	0.018
regulation of cell death	GO:0010941	173	0.018
regulation of mitosis	GO:0007088	56	0.018
stem cell division	GO:0017145	69	0.018
imaginal disc derived appendage development	GO:0048737	399	0.018
oviposition	GO:0018991	19	0.018
ras protein signal transduction	GO:0007265	88	0.018
male gamete generation	GO:0048232	201	0.017
regulation of cell proliferation	GO:0042127	163	0.017
regulation of cellular response to stress	GO:0080135	89	0.017
asymmetric stem cell division	GO:0098722	49	0.017
gland development	GO:0048732	191	0.017
regulation of phosphate metabolic process	GO:0019220	210	0.017
alternative mrna splicing via spliceosome	GO:0000380	60	0.017
cellular protein catabolic process	GO:0044257	83	0.017
head development	GO:0060322	135	0.017
multicellular organismal aging	GO:0010259	140	0.016
spinal cord development	GO:0021510	1	0.016
regulation of nuclear division	GO:0051783	58	0.016
rna splicing via transesterification reactions	GO:0000375	73	0.016
eye morphogenesis	GO:0048592	260	0.016
regulation of cellular catabolic process	GO:0031329	157	0.016
positive regulation of intracellular protein transport	GO:0090316	30	0.016
regulation of protein polymerization	GO:0032271	28	0.015
heterocycle catabolic process	GO:0046700	166	0.015
regulation of cellular protein catabolic process	GO:1903362	44	0.015
limb development	GO:0060173	1	0.015
protein localization to organelle	GO:0033365	82	0.015
negative regulation of cell cycle process	GO:0010948	109	0.015
chromatin modification	GO:0016568	147	0.015
regulation of cytoplasmic transport	GO:1903649	47	0.015
regulation of protein complex disassembly	GO:0043244	29	0.015
positive regulation of cellular amine metabolic process	GO:0033240	0	0.015
mitotic g2 m transition checkpoint	GO:0044818	70	0.015
intracellular signal transduction	GO:0035556	300	0.014
circulatory system development	GO:0072359	82	0.014
retina morphogenesis in camera type eye	GO:0060042	2	0.014
brain development	GO:0007420	120	0.014
regulation of rna splicing	GO:0043484	69	0.014
retina development in camera type eye	GO:0060041	4	0.014
regulation of chromosome segregation	GO:0051983	32	0.014
purine ribonucleotide metabolic process	GO:0009150	145	0.014
response to extracellular stimulus	GO:0009991	116	0.014
dendrite morphogenesis	GO:0048813	199	0.014
modification dependent protein catabolic process	GO:0019941	78	0.014
dendrite development	GO:0016358	204	0.014
establishment of spindle localization	GO:0051293	22	0.014
establishment or maintenance of cell polarity	GO:0007163	167	0.014
secretion	GO:0046903	109	0.013
mrna catabolic process	GO:0006402	33	0.013
regulation of translation	GO:0006417	56	0.013
spindle localization	GO:0051653	22	0.013
positive regulation of phosphorylation	GO:0042327	87	0.013
ubiquitin dependent protein catabolic process	GO:0006511	78	0.013
regulation of proteasomal protein catabolic process	GO:0061136	39	0.013
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.012
purine nucleotide metabolic process	GO:0006163	146	0.012
cellular ketone metabolic process	GO:0042180	24	0.012
positive regulation of cellular component biogenesis	GO:0044089	80	0.012
single organism membrane organization	GO:0044802	93	0.012
salivary gland cell autophagic cell death	GO:0035071	83	0.012
compound eye photoreceptor cell differentiation	GO:0001751	140	0.012
regulation of cellular component movement	GO:0051270	42	0.012
histone modification	GO:0016570	106	0.012
peptidyl threonine phosphorylation	GO:0018107	2	0.012
positive regulation of catalytic activity	GO:0043085	118	0.012
regulation of cell differentiation	GO:0045595	302	0.012
ribonucleotide metabolic process	GO:0009259	145	0.012
mitotic cytokinesis	GO:0000281	50	0.012
eye photoreceptor cell differentiation	GO:0001754	145	0.011
regulation of embryonic development	GO:0045995	68	0.011
determination of adult lifespan	GO:0008340	137	0.011
purine containing compound metabolic process	GO:0072521	155	0.011
spermatid differentiation	GO:0048515	114	0.011
positive regulation of intracellular transport	GO:0032388	42	0.011
negative regulation of protein maturation	GO:1903318	31	0.011
meiotic dna double strand break formation	GO:0042138	1	0.011
modification dependent macromolecule catabolic process	GO:0043632	79	0.011
positive regulation of protein modification process	GO:0031401	58	0.011
mitotic dna integrity checkpoint	GO:0044774	75	0.011
photoreceptor cell differentiation	GO:0046530	170	0.011
salivary gland histolysis	GO:0035070	88	0.011
secretion by cell	GO:0032940	101	0.011
mitotic nuclear division	GO:0007067	213	0.011
cellular response to organic substance	GO:0071310	132	0.011
mrna processing	GO:0006397	104	0.011
negative regulation of mitotic cell cycle	GO:0045930	109	0.011
defense response	GO:0006952	300	0.011
ribonucleoprotein complex subunit organization	GO:0071826	28	0.010
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.010
apoptotic process	GO:0006915	159	0.010
ribonucleoprotein complex assembly	GO:0022618	23	0.010
single organism biosynthetic process	GO:0044711	206	0.010
spermatogenesis	GO:0007283	200	0.010
protein dna complex assembly	GO:0065004	63	0.010
gene silencing	GO:0016458	138	0.010
ion transport	GO:0006811	145	0.010
negative regulation of phosphorus metabolic process	GO:0010563	45	0.010
response to biotic stimulus	GO:0009607	294	0.010

Aly disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.026
nervous system disease	DOID:863	0.026
central nervous system disease	DOID:331	0.016

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