IMP: Integrative Multi-species Prediction

Drosophila melanogaster

9 known processes

UbcD4 (Dmel_CG8284)

Ubiquitin conjugating enzyme 4

(Aliases: Dmel\CG8284,CG8284,E2)

Entrez: 39133
FLYBASE: FBgn0015321
UniProtKB: P52486
UniProtKB: X2JAX3

Process Predictions
Disease Predictions

UbcD4 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
negative regulation of cellular biosynthetic process	GO:0031327	277	0.275
negative regulation of cellular metabolic process	GO:0031324	382	0.202
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.194
cellular response to dna damage stimulus	GO:0006974	223	0.167
organic substance catabolic process	GO:1901575	308	0.149	Yeast Mouse
negative regulation of rna biosynthetic process	GO:1902679	240	0.141
negative regulation of gene expression	GO:0010629	387	0.138
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.118
secretion	GO:0046903	109	0.113
transcription from rna polymerase ii promoter	GO:0006366	368	0.103
cellular protein modification process	GO:0006464	438	0.100	Human Yeast
catabolic process	GO:0009056	409	0.092	Yeast Mouse
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.090
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.089
negative regulation of biosynthetic process	GO:0009890	277	0.083
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.081
negative regulation of transcription dna templated	GO:0045892	237	0.080
lipid localization	GO:0010876	54	0.078
posttranscriptional regulation of gene expression	GO:0010608	145	0.064
small molecule metabolic process	GO:0044281	305	0.064
vesicle mediated transport	GO:0016192	381	0.064
positive regulation of macromolecule metabolic process	GO:0010604	405	0.063
macromolecule catabolic process	GO:0009057	161	0.059	Yeast Mouse
protein catabolic process	GO:0030163	101	0.058	Yeast Mouse
response to other organism	GO:0051707	293	0.058
response to nitrogen compound	GO:1901698	90	0.057
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.057
dna integrity checkpoint	GO:0031570	81	0.052
carboxylic acid metabolic process	GO:0019752	92	0.049
dna damage checkpoint	GO:0000077	78	0.047
defense response	GO:0006952	300	0.046
mitotic g2 dna damage checkpoint	GO:0007095	69	0.045
phosphorylation	GO:0016310	294	0.044
intracellular signal transduction	GO:0035556	300	0.044
mitotic nuclear division	GO:0007067	213	0.044
cellular response to chemical stimulus	GO:0070887	199	0.042
positive regulation of biosynthetic process	GO:0009891	316	0.042
chromatin silencing	GO:0006342	76	0.041
imaginal disc derived wing morphogenesis	GO:0007476	337	0.041
regulation of gene silencing	GO:0060968	63	0.040
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.039
cellular macromolecule catabolic process	GO:0044265	136	0.039	Yeast Mouse
response to endogenous stimulus	GO:0009719	119	0.038
endocytosis	GO:0006897	310	0.038
positive regulation of rna metabolic process	GO:0051254	271	0.038
protein modification by small protein conjugation or removal	GO:0070647	106	0.037	Human Yeast
negative regulation of gene expression epigenetic	GO:0045814	77	0.035
regulation of protein metabolic process	GO:0051246	256	0.034	Mouse
response to radiation	GO:0009314	155	0.034
g2 dna damage checkpoint	GO:0031572	69	0.034
regulation of mitotic cell cycle	GO:0007346	190	0.032
regulation of intracellular signal transduction	GO:1902531	236	0.032
nuclear division	GO:0000280	332	0.032
organonitrogen compound metabolic process	GO:1901564	318	0.032
regulation of cell differentiation	GO:0045595	302	0.032
response to abiotic stimulus	GO:0009628	341	0.031
response to external biotic stimulus	GO:0043207	293	0.031
protein modification process	GO:0036211	438	0.031	Human Yeast
ras protein signal transduction	GO:0007265	88	0.031
histone modification	GO:0016570	106	0.030
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.030
protein k48 linked ubiquitination	GO:0070936	3	0.030	Human
positive regulation of cellular biosynthetic process	GO:0031328	316	0.029
cellular catabolic process	GO:0044248	372	0.029	Yeast Mouse
mitotic cell cycle checkpoint	GO:0007093	88	0.029
organophosphate metabolic process	GO:0019637	195	0.029
single organism biosynthetic process	GO:0044711	206	0.028
male gamete generation	GO:0048232	201	0.028
nucleobase containing compound catabolic process	GO:0034655	165	0.028
intracellular transport	GO:0046907	228	0.028
positive regulation of protein metabolic process	GO:0051247	128	0.027
positive regulation of multicellular organismal process	GO:0051240	143	0.027
aging	GO:0007568	143	0.027
cellular response to organic substance	GO:0071310	132	0.027
negative regulation of mitotic cell cycle	GO:0045930	109	0.026
organelle fission	GO:0048285	340	0.026
positive regulation of rna biosynthetic process	GO:1902680	266	0.026
lipid metabolic process	GO:0006629	121	0.026
chromosome segregation	GO:0007059	157	0.025
single organism intracellular transport	GO:1902582	207	0.025
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.025
epithelial cell differentiation	GO:0030855	322	0.025
organic substance transport	GO:0071702	257	0.025
imaginal disc derived appendage development	GO:0048737	399	0.025
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.024	Yeast Mouse
photoreceptor cell differentiation	GO:0046530	170	0.024
ribonucleotide metabolic process	GO:0009259	145	0.024
positive regulation of phosphate metabolic process	GO:0045937	139	0.024
mitotic dna damage checkpoint	GO:0044773	74	0.023
establishment of localization in cell	GO:0051649	402	0.023
regulation of apoptotic process	GO:0042981	130	0.023
epithelial cell development	GO:0002064	274	0.023
gene silencing	GO:0016458	138	0.023
response to organonitrogen compound	GO:0010243	75	0.023
organic cyclic compound catabolic process	GO:1901361	168	0.023
negative regulation of rna metabolic process	GO:0051253	251	0.022
apoptotic process	GO:0006915	159	0.022
epithelial cell migration	GO:0010631	148	0.022
mitotic dna integrity checkpoint	GO:0044774	75	0.022
protein modification by small protein conjugation	GO:0032446	79	0.022	Human Yeast
regulation of response to stress	GO:0080134	200	0.022
dna metabolic process	GO:0006259	227	0.021
regulation of cell cycle	GO:0051726	291	0.021
proteolysis	GO:0006508	192	0.021	Yeast Mouse
programmed cell death	GO:0012501	257	0.021
response to biotic stimulus	GO:0009607	294	0.021
positive regulation of cellular protein metabolic process	GO:0032270	118	0.021
cell cell junction organization	GO:0045216	55	0.021
cellular nitrogen compound catabolic process	GO:0044270	165	0.020
macromolecular complex assembly	GO:0065003	256	0.020
negative regulation of programmed cell death	GO:0043069	72	0.020
positive regulation of developmental growth	GO:0048639	62	0.020
positive regulation of cellular catabolic process	GO:0031331	95	0.020
positive regulation of transcription dna templated	GO:0045893	266	0.019
stem cell maintenance	GO:0019827	67	0.019
developmental maturation	GO:0021700	172	0.019
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.019
response to organic substance	GO:0010033	284	0.019
regulation of cellular amine metabolic process	GO:0033238	3	0.019
response to light stimulus	GO:0009416	124	0.019
positive regulation of phosphorus metabolic process	GO:0010562	139	0.018
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.018
secretion by cell	GO:0032940	101	0.018
regulation of cell death	GO:0010941	173	0.018
regulation of gene expression epigenetic	GO:0040029	128	0.018
regulation of cellular localization	GO:0060341	136	0.018
rna processing	GO:0006396	147	0.018
regulation of localization	GO:0032879	275	0.018
negative regulation of developmental process	GO:0051093	201	0.018
chromosome organization	GO:0051276	360	0.017
cellular lipid metabolic process	GO:0044255	83	0.017
male meiosis	GO:0007140	52	0.017
negative regulation of multicellular organismal process	GO:0051241	142	0.017
oxoacid metabolic process	GO:0043436	103	0.017
regulation of developmental growth	GO:0048638	174	0.017
regulation of molecular function	GO:0065009	217	0.017
regulation of translation	GO:0006417	56	0.017
embryo development ending in birth or egg hatching	GO:0009792	152	0.017
cellular protein catabolic process	GO:0044257	83	0.016	Yeast Mouse
dorsal ventral pattern formation	GO:0009953	133	0.016
cellular response to extracellular stimulus	GO:0031668	64	0.016
chromatin organization	GO:0006325	207	0.016
positive regulation of catabolic process	GO:0009896	105	0.016
regulation of cell cycle phase transition	GO:1901987	130	0.016
protein transport	GO:0015031	155	0.016
cell cycle checkpoint	GO:0000075	95	0.015
positive regulation of signal transduction	GO:0009967	223	0.015
eye development	GO:0001654	323	0.015
negative regulation of cell cycle process	GO:0010948	109	0.015
regulation of vesicle mediated transport	GO:0060627	59	0.015
epithelium migration	GO:0090132	148	0.015
small gtpase mediated signal transduction	GO:0007264	88	0.015
lateral inhibition	GO:0046331	206	0.015
regulation of phosphate metabolic process	GO:0019220	210	0.015
stem cell division	GO:0017145	69	0.014
cellular amino acid metabolic process	GO:0006520	61	0.014
regulation of phosphorus metabolic process	GO:0051174	210	0.014
regulation of cellular protein metabolic process	GO:0032268	243	0.014	Mouse
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.014
negative regulation of cell death	GO:0060548	81	0.014
positive regulation of protein modification process	GO:0031401	58	0.014
nucleobase containing small molecule metabolic process	GO:0055086	174	0.014
development of primary sexual characteristics	GO:0045137	50	0.014
regulation of cellular ketone metabolic process	GO:0010565	3	0.014
cell cycle phase transition	GO:0044770	140	0.014
body morphogenesis	GO:0010171	2	0.013
immune system process	GO:0002376	347	0.013
nucleotide metabolic process	GO:0009117	161	0.013
rna splicing	GO:0008380	83	0.013
negative regulation of cell communication	GO:0010648	223	0.013
stem cell differentiation	GO:0048863	117	0.013
covalent chromatin modification	GO:0016569	106	0.013
regulation of cell development	GO:0060284	215	0.013
cell maturation	GO:0048469	144	0.013
multicellular organismal aging	GO:0010259	140	0.013
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.013
developmental growth	GO:0048589	280	0.013
phagocytosis	GO:0006909	215	0.013
reproductive structure development	GO:0048608	74	0.013
positive regulation of cell communication	GO:0010647	250	0.012
tissue migration	GO:0090130	155	0.012
regulation of cell cycle process	GO:0010564	181	0.012
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.012
amine metabolic process	GO:0009308	12	0.012
positive regulation of signaling	GO:0023056	243	0.012
negative regulation of cell differentiation	GO:0045596	143	0.011
defense response to other organism	GO:0098542	225	0.011
homeostatic process	GO:0042592	199	0.011
rna splicing via transesterification reactions	GO:0000375	73	0.011
negative regulation of response to stimulus	GO:0048585	258	0.011
multi organism behavior	GO:0051705	175	0.011
developmental programmed cell death	GO:0010623	138	0.011
response to organic cyclic compound	GO:0014070	89	0.011
post embryonic appendage morphogenesis	GO:0035120	385	0.011
maintenance of location	GO:0051235	73	0.011
purine nucleotide metabolic process	GO:0006163	146	0.011
regulation of transport	GO:0051049	181	0.011
regulation of anatomical structure size	GO:0090066	163	0.011
proteasomal protein catabolic process	GO:0010498	59	0.011	Yeast Mouse
regulation of anatomical structure morphogenesis	GO:0022603	242	0.011
reproductive system development	GO:0061458	74	0.011
protein phosphorylation	GO:0006468	169	0.011
embryonic development via the syncytial blastoderm	GO:0001700	148	0.010
regulation of cell projection organization	GO:0031344	92	0.010
regulation of multicellular organismal development	GO:2000026	414	0.010
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.010
regulation of catabolic process	GO:0009894	170	0.010	Mouse
aromatic compound catabolic process	GO:0019439	166	0.010
carbohydrate metabolic process	GO:0005975	82	0.010
establishment of organelle localization	GO:0051656	122	0.010

UbcD4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.060
	nervous system disease	DOID:863	0	0.017

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