Drosophila melanogaster

99 known processes

Lrrk (Dmel_CG5483)

Leucine-rich repeat kinase

(Aliases: dLRRK,Dmel\CG5483,CG5483,LRRK,CT17358,lrrk)

Lrrk biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
neuromuscular junction developmentGO:00075281490.922
synaptic transmissionGO:00072682880.884
cellular protein modification processGO:00064644380.543
cilium assemblyGO:0042384380.458
protein modification by small protein conjugation or removalGO:00706471060.457
Human
adult locomotory behaviorGO:0008344760.443
negative regulation of nervous system developmentGO:0051961920.442
dna metabolic processGO:00062592270.441
sperm mitochondrion organizationGO:003038270.394
tube developmentGO:00352952440.394
regulation of cellular component biogenesisGO:00440872010.366
synaptic growth at neuromuscular junctionGO:00511241190.341
regulation of neuron projection developmentGO:0010975690.323
Human Mouse
adult behaviorGO:00305341370.319
establishment of organelle localizationGO:00516561220.317
cell growthGO:00160491080.306
Worm
organelle localizationGO:00516401480.289
signal releaseGO:0023061490.289
Human
synapse organizationGO:00508081960.283
protein modification processGO:00362114380.263
regulation of synaptic transmissionGO:0050804690.259
single organism cellular localizationGO:19025801800.246
regionalizationGO:00030024160.244
negative regulation of cell communicationGO:00106482230.243
purine nucleotide metabolic processGO:00061631460.223
Human
aromatic compound catabolic processGO:00194391660.207
Human
homeostatic processGO:00425921990.203
Human Mouse
ribose phosphate metabolic processGO:00196931450.202
Human
locomotory behaviorGO:00076261760.202
Mouse
regulation of neurotransmitter levelsGO:0001505380.201
Human
ribonucleotide metabolic processGO:00092591450.196
Human
developmental growthGO:00485892800.193
Worm
cation transmembrane transportGO:0098655880.188
ribonucleoside metabolic processGO:00091191270.187
Human
growthGO:00400073590.186
Worm
cellular response to dna damage stimulusGO:00069742230.184
vesicle localizationGO:0051648550.184
glycosyl compound metabolic processGO:19016571270.173
Human
synapse assemblyGO:00074161430.173
nucleotide metabolic processGO:00091171610.171
Human
synaptic vesicle transportGO:0048489500.171
purine ribonucleoside triphosphate metabolic processGO:00092051190.171
Human
purine ribonucleotide metabolic processGO:00091501450.170
Human
regulation of nervous system developmentGO:00519602480.168
catabolic processGO:00090564090.166
Human Mouse
nucleobase containing compound catabolic processGO:00346551650.157
Human
nucleoside catabolic processGO:00091641120.155
Human
macromolecular complex assemblyGO:00650032560.143
organic substance catabolic processGO:19015753080.142
Human Mouse
regulation of growthGO:00400082330.139
purine nucleotide catabolic processGO:00061951090.138
Human
dendrite developmentGO:00163582040.137
Human Mouse
purine nucleoside monophosphate metabolic processGO:0009126500.133
regulation of secretion by cellGO:1903530390.131
Human
synaptic vesicle localizationGO:0097479530.128
ribonucleoside triphosphate catabolic processGO:00092031080.124
Human
organelle fissionGO:00482853400.124
protein localizationGO:00081042840.121
Human Mouse Worm
brain developmentGO:00074201200.121
Human
axonogenesisGO:00074092900.119
Worm
purine nucleoside triphosphate metabolic processGO:00091441190.118
Human
purine containing compound metabolic processGO:00725211550.116
Human
cellular macromolecule localizationGO:00707272200.115
Human Mouse Worm
regulation of localizationGO:00328792750.115
cellular catabolic processGO:00442483720.113
Human Mouse
regulation of dendrite morphogenesisGO:0048814280.112
Human Mouse
neuron neuron synaptic transmissionGO:0007270140.111
Mouse
regulation of multicellular organismal developmentGO:20000264140.111
purine nucleoside metabolic processGO:00422781270.111
Human
positive regulation of signal transductionGO:00099672230.108
Human Mouse
nucleoside triphosphate metabolic processGO:00091411200.106
Human
cell deathGO:00082192790.105
Human
regulation of synaptic growth at neuromuscular junctionGO:0008582890.104
tube morphogenesisGO:00352391910.104
nucleoside triphosphate catabolic processGO:00091431080.104
Human
response to organonitrogen compoundGO:0010243750.104
Human
nuclear divisionGO:00002803320.103
regulation of neurogenesisGO:00507671580.101
Human Mouse
cellular component assembly involved in morphogenesisGO:00109271510.101
regulation of cell projection organizationGO:0031344920.101
Human Mouse
regulation of vesicle mediated transportGO:0060627590.101
programmed cell deathGO:00125012570.100
Human
ribonucleoside triphosphate metabolic processGO:00091991190.100
Human
regulation of phosphorus metabolic processGO:00511742100.099
Human Mouse
organophosphate catabolic processGO:00464341120.097
Human
deathGO:00162652840.095
Human
exocytosisGO:0006887280.093
Human
establishment of vesicle localizationGO:0051650510.092
negative regulation of gene expression epigeneticGO:0045814770.090
response to oxygen containing compoundGO:19017002000.089
Human
positive regulation of cellular component organizationGO:00511301560.089
regulation of cellular protein metabolic processGO:00322682430.088
Human Mouse
positive regulation of cell communicationGO:00106472500.087
Human Mouse
organophosphate metabolic processGO:00196371950.084
Human
mitochondrion organizationGO:0007005650.084
regulation of transportGO:00510491810.083
protein ubiquitinationGO:0016567700.081
Human
regulation of cellular amino acid metabolic processGO:000652100.081
cellular nitrogen compound catabolic processGO:00442701650.078
Human
chromosome segregationGO:00070591570.076
ribonucleotide catabolic processGO:00092611090.075
Human
negative regulation of signal transductionGO:00099682060.075
cellular protein localizationGO:00346131600.075
Human Mouse Worm
positive regulation of biosynthetic processGO:00098913160.073
cellular response to oxygen containing compoundGO:1901701790.072
Human
ribonucleoside monophosphate metabolic processGO:0009161510.072
single organism membrane organizationGO:0044802930.072
organonitrogen compound metabolic processGO:19015643180.071
Human
response to organic substanceGO:00100332840.071
Human
small molecule metabolic processGO:00442813050.071
Human
positive regulation of multicellular organismal processGO:00512401430.070
negative regulation of cellular metabolic processGO:00313243820.070
Human Mouse
synaptic vesicle endocytosisGO:0048488280.069
nucleoside monophosphate metabolic processGO:0009123520.068
heterocycle catabolic processGO:00467001660.068
Human
nucleoside phosphate metabolic processGO:00067531620.068
Human
dorsal ventral pattern formationGO:00099531330.068
transmembrane transportGO:00550851390.067
regulation of programmed cell deathGO:00430671520.067
Human
cell divisionGO:00513012480.067
regulation of protein ubiquitinationGO:0031396220.066
Human
transcription from rna polymerase ii promoterGO:00063663680.066
cell migrationGO:00164772380.066
Human
negative regulation of multicellular organismal processGO:00512411420.066
positive regulation of cellular biosynthetic processGO:00313283160.066
ribonucleoside catabolic processGO:00424541120.066
Human
embryonic development via the syncytial blastodermGO:00017001480.066
single organism intracellular transportGO:19025822070.066
Human
mrna metabolic processGO:00160711240.065
atp metabolic processGO:0046034490.065
axon guidanceGO:00074112330.065
Worm
establishment of localization in cellGO:00516494020.064
cellular macromolecular complex assemblyGO:00346221530.063
organelle fusionGO:0048284460.063
synaptic vesicle recyclingGO:0036465280.063
skin developmentGO:0043588650.063
cellular macromolecule catabolic processGO:00442651360.060
Mouse
purine ribonucleoside catabolic processGO:00461301120.059
Human
cellular homeostasisGO:0019725800.059
regulation of protein modification processGO:00313991120.058
Human Mouse
cellular amino acid metabolic processGO:0006520610.058
multicellular organismal agingGO:00102591400.058
Human
protein modification by small protein removalGO:0070646280.058
inositol lipid mediated signalingGO:004801740.058
meiotic cell cycle processGO:19030461320.057
negative regulation of signalingGO:00230572190.057
establishment of synaptic vesicle localizationGO:0097480500.056
cell motilityGO:00488702510.056
Human
regulation of neuron differentiationGO:00456641030.056
Human Mouse
phosphorylationGO:00163102940.056
meiotic chromosome segregationGO:0045132590.055
positive regulation of neurogenesisGO:0050769410.055
regulation of apoptotic processGO:00429811300.055
phosphatidylinositol mediated signalingGO:004801540.055
central nervous system developmentGO:00074172010.053
Human
single organism catabolic processGO:00447122280.053
Human
positive regulation of signalingGO:00230562430.052
Human Mouse
negative regulation of gene expressionGO:00106293870.052
Human
intracellular transportGO:00469072280.052
Human
microtubule based transportGO:0010970420.052
apoptotic processGO:00069151590.051
membrane organizationGO:00610241120.050
regulation of organelle organizationGO:00330431960.050
chemotaxisGO:00069352490.050
Worm
posttranscriptional regulation of gene expressionGO:00106081450.050
chromatin assemblyGO:0031497480.049
regulation of catabolic processGO:00098941700.049
Human Mouse
purine ribonucleoside metabolic processGO:00461281270.049
Human
cilium organizationGO:0044782410.049
purine containing compound catabolic processGO:00725231120.048
Human
neurotransmitter transportGO:0006836370.048
Human
epidermis developmentGO:0008544650.048
purine ribonucleoside monophosphate metabolic processGO:0009167500.048
proteolysis involved in cellular protein catabolic processGO:0051603830.048
Mouse
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.047
protein complex biogenesisGO:00702712010.047
anatomical structure homeostasisGO:0060249970.047
Mouse
nucleoside metabolic processGO:00091161270.046
Human
carbohydrate derivative metabolic processGO:19011352170.045
Human
purine ribonucleotide catabolic processGO:00091541090.045
Human
intracellular protein transportGO:00068861040.044
Human
positive regulation of nervous system developmentGO:0051962690.043
cellular response to chemical stimulusGO:00708871990.043
Human
positive regulation of secretion by cellGO:1903532200.043
intracellular signal transductionGO:00355563000.043
Human Mouse
regulation of anatomical structure morphogenesisGO:00226032420.043
Human Mouse
positive regulation of phosphorus metabolic processGO:00105621390.043
Human Mouse
positive regulation of nucleobase containing compound metabolic processGO:00459353320.042
Human
meiotic nuclear divisionGO:00071261510.042
regulation of response to dna damage stimulusGO:2001020230.042
carbohydrate derivative catabolic processGO:19011361180.042
Human
regulation of protein localizationGO:0032880760.041
Human
endosomal transportGO:0016197440.040
inorganic cation transmembrane transportGO:0098662610.040
negative regulation of neurogenesisGO:0050768530.040
regulation of cellular response to stressGO:0080135890.040
Human
positive regulation of cellular amino acid metabolic processGO:004576400.040
spermatogenesisGO:00072832000.040
mapk cascadeGO:00001651070.039
Human
negative regulation of nucleobase containing compound metabolic processGO:00459342610.039
Human
positive regulation of response to stimulusGO:00485843230.039
Human Mouse
organonitrogen compound catabolic processGO:19015651280.039
Human
purine nucleoside catabolic processGO:00061521120.039
Human
nucleobase containing small molecule metabolic processGO:00550861740.039
Human
regulation of anatomical structure sizeGO:00900661630.039
Mouse
positive regulation of jun kinase activityGO:004350740.038
regulation of protein metabolic processGO:00512462560.037
Human Mouse
sister chromatid segregationGO:0000819920.037
cation homeostasisGO:0055080510.037
necrotic cell deathGO:007026510.037
forebrain developmentGO:003090020.037
Human
organic cyclic compound catabolic processGO:19013611680.036
Human
organic substance transportGO:00717022570.035
Human
dendrite morphogenesisGO:00488131990.035
Human Mouse
positive regulation of rna biosynthetic processGO:19026802660.035
cellular ion homeostasisGO:0006873390.034
positive regulation of organelle organizationGO:0010638650.034
regulation of molecular functionGO:00650092170.033
Human
regulation of synapse assemblyGO:0051963940.033
regulation of developmental growthGO:00486381740.033
ion transportGO:00068111450.033
cytoplasmic transportGO:00164821300.033
Human
vesicle mediated transportGO:00161923810.033
positive regulation of nucleic acid templated transcriptionGO:19035082660.032
positive regulation of cellular component biogenesisGO:0044089800.032
regulation of phosphate metabolic processGO:00192202100.032
Human Mouse
regulation of transcription from rna polymerase ii promoterGO:00063573780.031
neurotransmitter secretionGO:0007269350.031
Human
rna processingGO:00063961470.031
metal ion homeostasisGO:0055065440.030
establishment or maintenance of cell polarityGO:00071631670.030
nucleotide catabolic processGO:00091661090.030
Human
protein modification by small protein conjugationGO:0032446790.030
Human
male gamete generationGO:00482322010.030
cell projection assemblyGO:0030031940.029
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.029
cellular response to endogenous stimulusGO:0071495800.029
Human
negative regulation of growthGO:0045926840.029
regulation of cell developmentGO:00602842150.029
Human Mouse
protein phosphorylationGO:00064681690.029
gene silencingGO:00164581380.029
negative regulation of cellular component organizationGO:00511291080.029
Human
regulation of cellular localizationGO:00603411360.028
negative regulation of cell developmentGO:0010721620.028
atp catabolic processGO:0006200380.028
developmental cell growthGO:0048588520.028
Worm
regulation of gene expression epigeneticGO:00400291280.028
regulation of protein kinase activityGO:0045859510.027
Human
digestive system developmentGO:00551231490.027
organic acid metabolic processGO:00060821030.027
embryo development ending in birth or egg hatchingGO:00097921520.027
peptidyl amino acid modificationGO:00181931050.026
positive regulation of cell migrationGO:003033520.026
eye developmentGO:00016543230.026
dorsal closureGO:0007391790.026
positive regulation of programmed cell deathGO:0043068620.026
Human
head developmentGO:00603221350.026
Human
spermatid differentiationGO:00485151140.026
female meiotic divisionGO:0007143700.026
proteolysisGO:00065081920.025
Mouse
negative regulation of phosphorylationGO:0042326350.025
Mouse
regulation of cellular catabolic processGO:00313291570.025
Human Mouse
epithelial cell developmentGO:00020642740.025
glycosyl compound catabolic processGO:19016581120.025
Human
regulation of excitatory postsynaptic membrane potentialGO:006007930.025
Mouse
regulation of protein modification by small protein conjugation or removalGO:1903320250.024
Human
positive regulation of cell developmentGO:0010720610.024
protein complex assemblyGO:00064612000.024
organelle assemblyGO:00709251980.024
ribonucleoside monophosphate catabolic processGO:0009158390.024
columnar cuboidal epithelial cell differentiationGO:00020652560.023
positive regulation of intracellular signal transductionGO:19025331160.023
Human Mouse
mitochondrion degradationGO:000042280.023
regulation of synapse organizationGO:00508071100.023
positive regulation of protein modification processGO:0031401580.023
Human Mouse
regulation of cellular ketone metabolic processGO:001056530.023
positive regulation of cell motilityGO:200014730.023
agingGO:00075681430.023
Human
cellular protein complex assemblyGO:0043623710.022
establishment of protein localizationGO:00451841630.022
Human
positive regulation of developmental processGO:00510941430.022
cytokinesisGO:0000910900.022
regulation of endocytosisGO:0030100370.021
modification dependent macromolecule catabolic processGO:0043632790.021
Mouse
purine ribonucleoside triphosphate catabolic processGO:00092071080.021
Human
regulation of nucleoside metabolic processGO:0009118500.021
Human
negative regulation of response to stimulusGO:00485852580.021
Human
regulation of cell deathGO:00109411730.021
Human
regulation of protein catabolic processGO:0042176550.021
Mouse
regulation of phosphorylationGO:00423251470.020
Human Mouse
regulation of synaptic vesicle endocytosisGO:190024270.020
calcium ion transportGO:0006816240.020
localization of cellGO:00516742570.020
Human
enzyme linked receptor protein signaling pathwayGO:00071671790.020
regulation of response to stressGO:00801342000.020
Human
purine ribonucleoside monophosphate catabolic processGO:0009169380.020
positive regulation of transcription dna templatedGO:00458932660.019
response to organic cyclic compoundGO:0014070890.019
Human
phosphatidylinositol 3 kinase signalingGO:001406540.019
macromolecule catabolic processGO:00090571610.018
Mouse
regulation of microtubule cytoskeleton organizationGO:0070507410.018
negative regulation of cell differentiationGO:00455961430.018
protein polymerizationGO:0051258420.018
negative regulation of organelle organizationGO:0010639560.018
Human
cation transportGO:00068121100.018
stress activated mapk cascadeGO:0051403520.018
dna packagingGO:0006323910.018
nitrogen compound transportGO:0071705850.018
cellular divalent inorganic cation homeostasisGO:0072503230.018
positive regulation of nitrogen compound metabolic processGO:00511733540.018
Human
epithelium migrationGO:00901321480.018
positive regulation of catalytic activityGO:00430851180.018
Human
ion transmembrane transportGO:00342201220.018
chromatin modificationGO:00165681470.018
protein deubiquitinationGO:0016579170.017
negative regulation of developmental processGO:00510932010.017
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161540.017
Mouse
vesicle organizationGO:0016050440.017
negative regulation of protein metabolic processGO:0051248850.017
Human Mouse
membrane fusionGO:0061025420.017
synaptic vesicle exocytosisGO:0016079160.017
Human
cellular response to organic substanceGO:00713101320.017
Human
organ growthGO:0035265560.017
response to endogenous stimulusGO:00097191190.017
Human
peptidyl tyrosine phosphorylationGO:0018108240.017
Mouse
actin filament bundle assemblyGO:0051017260.017
regulation of dna metabolic processGO:0051052340.017
cellular response to nutrient levelsGO:0031669620.017
positive regulation of apoptotic signaling pathwayGO:200123540.016
terminal button organizationGO:0072553190.016
microtubule polymerization or depolymerizationGO:0031109390.016
modification dependent protein catabolic processGO:0019941780.016
Mouse
oxidation reduction processGO:00551141230.016
Human
camera type eye morphogenesisGO:004859320.016
microtubule based movementGO:0007018510.016
response to nitrogen compoundGO:1901698900.016
Human
purine nucleoside triphosphate catabolic processGO:00091461080.016
Human
nucleoside monophosphate catabolic processGO:0009125390.016
autophagyGO:00069141080.016
Human Mouse
endomembrane system organizationGO:00102561190.016
regulation of cell differentiationGO:00455953020.016
Human Mouse
negative regulation of cellular catabolic processGO:0031330340.016
Human
translationGO:0006412690.015
meiotic cell cycleGO:00513211710.015
response to oxidative stressGO:0006979860.015
Human Worm
imaginal disc pattern formationGO:0007447910.015
eye morphogenesisGO:00485922600.015
sensory organ morphogenesisGO:00905962600.015
regulation of cellular amine metabolic processGO:003323830.015
mrna catabolic processGO:0006402330.015
protein localization to organelleGO:0033365820.015
Human
positive regulation of catabolic processGO:00098961050.015
Human Mouse
regulation of response to oxidative stressGO:190288240.015
Human
hindbrain developmentGO:003090220.015
spinal cord developmentGO:002151010.015
positive regulation of molecular functionGO:00440931360.014
Human
positive regulation of synapse assemblyGO:0051965290.014
actin filament based processGO:00300292200.014
steroid biosynthetic processGO:0006694160.014
developmental growth involved in morphogenesisGO:0060560650.014
Worm
regulation of meiosisGO:004002030.014
carboxylic acid metabolic processGO:0019752920.014
heterochromatin organizationGO:0070828250.014
regulation of purine nucleotide catabolic processGO:0033121480.014
Human
mitotic spindle organizationGO:00070522200.014
small rna loading onto riscGO:007092260.014
regulation of protein polymerizationGO:0032271280.013
regulation of synaptic plasticityGO:0048167140.013
regulation of synaptic activityGO:006002590.013
ras protein signal transductionGO:0007265880.013
blastoderm segmentationGO:00073501590.013
microtubule depolymerizationGO:0007019250.013
gene silencing by rnaGO:0031047570.013
regulation of intracellular signal transductionGO:19025312360.013
Human Mouse
production of small rna involved in gene silencing by rnaGO:0070918150.013
regulation of erbb signaling pathwayGO:1901184420.013
regulation of synaptic vesicle transportGO:1902803100.013
signal transduction by phosphorylationGO:00230141070.013
Human
regulation of wnt signaling pathwayGO:0030111680.013
mrna processingGO:00063971040.013
positive regulation of purine nucleotide metabolic processGO:1900544550.013
Human
regulation of ras protein signal transductionGO:0046578930.013
purine nucleoside monophosphate catabolic processGO:0009128380.013
axon extensionGO:0048675320.013
Worm
protein targetingGO:0006605640.012
Human
imaginal disc derived appendage developmentGO:00487373990.012
metal ion transportGO:0030001740.012
stress activated protein kinase signaling cascadeGO:0031098550.012
response to temperature stimulusGO:00092661060.012
neuromuscular synaptic transmissionGO:0007274670.012
apoptotic signaling pathwayGO:0097190270.012
cytoskeleton dependent intracellular transportGO:0030705440.012
columnar cuboidal epithelial cell developmentGO:00020662490.012
regulation of cellular component sizeGO:0032535980.012
cellular ketone metabolic processGO:0042180240.012
regulation of cell morphogenesisGO:00226041630.012
Human Mouse
reproductive system developmentGO:0061458740.012
regulation of synaptic vesicle exocytosisGO:200030030.012
Human
response to radiationGO:00093141550.012
regulation of synapse structure and activityGO:00508031280.012
regulation of protein complex assemblyGO:0043254420.012
regulation of cell substrate adhesionGO:001081020.012
carbohydrate derivative biosynthetic processGO:1901137850.012
positive regulation of protein complex assemblyGO:0031334220.012
oxoacid metabolic processGO:00434361030.012
regulation of hemocyte proliferationGO:0035206370.011
ion homeostasisGO:0050801550.011
Human
negative regulation of catabolic processGO:0009895360.011
Human
regulation of actin filament bundle assemblyGO:003223180.011
positive regulation of mapk cascadeGO:0043410630.011
Human
regulation of proteolysis involved in cellular protein catabolic processGO:1903050440.011
Mouse
posttranscriptional gene silencingGO:0016441460.011
secretionGO:00469031090.011
Human
ameboidal type cell migrationGO:00016671510.011
germline stem cell asymmetric divisionGO:0098728150.011
positive regulation of macromolecule metabolic processGO:00106044050.011
Human Mouse
actin cytoskeleton organizationGO:00300362060.011
extrinsic apoptotic signaling pathwayGO:009719110.011
regulation of insulin receptor signaling pathwayGO:0046626170.011
mitotic nuclear divisionGO:00070672130.011
positive regulation of neuron differentiationGO:0045666260.011
regulation of organ growthGO:0046620420.011
sensory perception of smellGO:0007608800.011
neuron projection guidanceGO:00974852410.011
Worm
regulation of jnk cascadeGO:0046328400.011
embryonic pattern specificationGO:00098801740.011
negative regulation of synaptic growth at neuromuscular junctionGO:0045886390.010
periodic partitioningGO:0007365290.010
regulation of membrane potentialGO:0042391350.010
Human Mouse
negative regulation of multi organism processGO:0043901290.010
actin filament organizationGO:00070151260.010
camera type eye developmentGO:004301040.010
dna conformation changeGO:00711031050.010

Lrrk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.023
Human
central nervous system diseaseDOID:33100.023
Human
parkinson s diseaseDOID:1433000.023
Human
synucleinopathyDOID:005089000.023
Human
neurodegenerative diseaseDOID:128900.023
Human
disease of anatomical entityDOID:700.023
Human