IMP: Integrative Multi-species Prediction

Drosophila melanogaster

99 known processes

Lrrk (Dmel_CG5483)

Leucine-rich repeat kinase

(Aliases: dLRRK,Dmel\CG5483,CG5483,LRRK,CT17358,lrrk)

Entrez: 42447
FLYBASE: FBgn0038816
UniProtKB: Q9VDJ9

Process Predictions
Disease Predictions

Lrrk biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
neuromuscular junction development	GO:0007528	149	0.922
synaptic transmission	GO:0007268	288	0.884
cellular protein modification process	GO:0006464	438	0.543
cilium assembly	GO:0042384	38	0.458
protein modification by small protein conjugation or removal	GO:0070647	106	0.457	Human
adult locomotory behavior	GO:0008344	76	0.443
negative regulation of nervous system development	GO:0051961	92	0.442
dna metabolic process	GO:0006259	227	0.441
sperm mitochondrion organization	GO:0030382	7	0.394
tube development	GO:0035295	244	0.394
regulation of cellular component biogenesis	GO:0044087	201	0.366
synaptic growth at neuromuscular junction	GO:0051124	119	0.341
regulation of neuron projection development	GO:0010975	69	0.323	Human Mouse
adult behavior	GO:0030534	137	0.319
establishment of organelle localization	GO:0051656	122	0.317
cell growth	GO:0016049	108	0.306	Worm
organelle localization	GO:0051640	148	0.289
signal release	GO:0023061	49	0.289	Human
synapse organization	GO:0050808	196	0.283
protein modification process	GO:0036211	438	0.263
regulation of synaptic transmission	GO:0050804	69	0.259
single organism cellular localization	GO:1902580	180	0.246
regionalization	GO:0003002	416	0.244
negative regulation of cell communication	GO:0010648	223	0.243
purine nucleotide metabolic process	GO:0006163	146	0.223	Human
aromatic compound catabolic process	GO:0019439	166	0.207	Human
homeostatic process	GO:0042592	199	0.203	Human Mouse
ribose phosphate metabolic process	GO:0019693	145	0.202	Human
locomotory behavior	GO:0007626	176	0.202	Mouse
regulation of neurotransmitter levels	GO:0001505	38	0.201	Human
ribonucleotide metabolic process	GO:0009259	145	0.196	Human
developmental growth	GO:0048589	280	0.193	Worm
cation transmembrane transport	GO:0098655	88	0.188
ribonucleoside metabolic process	GO:0009119	127	0.187	Human
growth	GO:0040007	359	0.186	Worm
cellular response to dna damage stimulus	GO:0006974	223	0.184
vesicle localization	GO:0051648	55	0.184
glycosyl compound metabolic process	GO:1901657	127	0.173	Human
synapse assembly	GO:0007416	143	0.173
nucleotide metabolic process	GO:0009117	161	0.171	Human
synaptic vesicle transport	GO:0048489	50	0.171
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.171	Human
purine ribonucleotide metabolic process	GO:0009150	145	0.170	Human
regulation of nervous system development	GO:0051960	248	0.168
catabolic process	GO:0009056	409	0.166	Human Mouse
nucleobase containing compound catabolic process	GO:0034655	165	0.157	Human
nucleoside catabolic process	GO:0009164	112	0.155	Human
macromolecular complex assembly	GO:0065003	256	0.143
organic substance catabolic process	GO:1901575	308	0.142	Human Mouse
regulation of growth	GO:0040008	233	0.139
purine nucleotide catabolic process	GO:0006195	109	0.138	Human
dendrite development	GO:0016358	204	0.137	Human Mouse
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.133
regulation of secretion by cell	GO:1903530	39	0.131	Human
synaptic vesicle localization	GO:0097479	53	0.128
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.124	Human
organelle fission	GO:0048285	340	0.124
protein localization	GO:0008104	284	0.121	Human Mouse Worm
brain development	GO:0007420	120	0.121	Human
axonogenesis	GO:0007409	290	0.119	Worm
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.118	Human
purine containing compound metabolic process	GO:0072521	155	0.116	Human
cellular macromolecule localization	GO:0070727	220	0.115	Human Mouse Worm
regulation of localization	GO:0032879	275	0.115
cellular catabolic process	GO:0044248	372	0.113	Human Mouse
regulation of dendrite morphogenesis	GO:0048814	28	0.112	Human Mouse
neuron neuron synaptic transmission	GO:0007270	14	0.111	Mouse
regulation of multicellular organismal development	GO:2000026	414	0.111
purine nucleoside metabolic process	GO:0042278	127	0.111	Human
positive regulation of signal transduction	GO:0009967	223	0.108	Human Mouse
nucleoside triphosphate metabolic process	GO:0009141	120	0.106	Human
cell death	GO:0008219	279	0.105	Human
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.104
tube morphogenesis	GO:0035239	191	0.104
nucleoside triphosphate catabolic process	GO:0009143	108	0.104	Human
response to organonitrogen compound	GO:0010243	75	0.104	Human
nuclear division	GO:0000280	332	0.103
regulation of neurogenesis	GO:0050767	158	0.101	Human Mouse
cellular component assembly involved in morphogenesis	GO:0010927	151	0.101
regulation of cell projection organization	GO:0031344	92	0.101	Human Mouse
regulation of vesicle mediated transport	GO:0060627	59	0.101
programmed cell death	GO:0012501	257	0.100	Human
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.100	Human
regulation of phosphorus metabolic process	GO:0051174	210	0.099	Human Mouse
organophosphate catabolic process	GO:0046434	112	0.097	Human
death	GO:0016265	284	0.095	Human
exocytosis	GO:0006887	28	0.093	Human
establishment of vesicle localization	GO:0051650	51	0.092
negative regulation of gene expression epigenetic	GO:0045814	77	0.090
response to oxygen containing compound	GO:1901700	200	0.089	Human
positive regulation of cellular component organization	GO:0051130	156	0.089
regulation of cellular protein metabolic process	GO:0032268	243	0.088	Human Mouse
positive regulation of cell communication	GO:0010647	250	0.087	Human Mouse
organophosphate metabolic process	GO:0019637	195	0.084	Human
mitochondrion organization	GO:0007005	65	0.084
regulation of transport	GO:0051049	181	0.083
protein ubiquitination	GO:0016567	70	0.081	Human
regulation of cellular amino acid metabolic process	GO:0006521	0	0.081
cellular nitrogen compound catabolic process	GO:0044270	165	0.078	Human
chromosome segregation	GO:0007059	157	0.076
ribonucleotide catabolic process	GO:0009261	109	0.075	Human
negative regulation of signal transduction	GO:0009968	206	0.075
cellular protein localization	GO:0034613	160	0.075	Human Mouse Worm
positive regulation of biosynthetic process	GO:0009891	316	0.073
cellular response to oxygen containing compound	GO:1901701	79	0.072	Human
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.072
single organism membrane organization	GO:0044802	93	0.072
organonitrogen compound metabolic process	GO:1901564	318	0.071	Human
response to organic substance	GO:0010033	284	0.071	Human
small molecule metabolic process	GO:0044281	305	0.071	Human
positive regulation of multicellular organismal process	GO:0051240	143	0.070
negative regulation of cellular metabolic process	GO:0031324	382	0.070	Human Mouse
synaptic vesicle endocytosis	GO:0048488	28	0.069
nucleoside monophosphate metabolic process	GO:0009123	52	0.068
heterocycle catabolic process	GO:0046700	166	0.068	Human
nucleoside phosphate metabolic process	GO:0006753	162	0.068	Human
dorsal ventral pattern formation	GO:0009953	133	0.068
transmembrane transport	GO:0055085	139	0.067
regulation of programmed cell death	GO:0043067	152	0.067	Human
cell division	GO:0051301	248	0.067
regulation of protein ubiquitination	GO:0031396	22	0.066	Human
transcription from rna polymerase ii promoter	GO:0006366	368	0.066
cell migration	GO:0016477	238	0.066	Human
negative regulation of multicellular organismal process	GO:0051241	142	0.066
positive regulation of cellular biosynthetic process	GO:0031328	316	0.066
ribonucleoside catabolic process	GO:0042454	112	0.066	Human
embryonic development via the syncytial blastoderm	GO:0001700	148	0.066
single organism intracellular transport	GO:1902582	207	0.066	Human
mrna metabolic process	GO:0016071	124	0.065
atp metabolic process	GO:0046034	49	0.065
axon guidance	GO:0007411	233	0.065	Worm
establishment of localization in cell	GO:0051649	402	0.064
cellular macromolecular complex assembly	GO:0034622	153	0.063
organelle fusion	GO:0048284	46	0.063
synaptic vesicle recycling	GO:0036465	28	0.063
skin development	GO:0043588	65	0.063
cellular macromolecule catabolic process	GO:0044265	136	0.060	Mouse
purine ribonucleoside catabolic process	GO:0046130	112	0.059	Human
cellular homeostasis	GO:0019725	80	0.059
regulation of protein modification process	GO:0031399	112	0.058	Human Mouse
cellular amino acid metabolic process	GO:0006520	61	0.058
multicellular organismal aging	GO:0010259	140	0.058	Human
protein modification by small protein removal	GO:0070646	28	0.058
inositol lipid mediated signaling	GO:0048017	4	0.058
meiotic cell cycle process	GO:1903046	132	0.057
negative regulation of signaling	GO:0023057	219	0.057
establishment of synaptic vesicle localization	GO:0097480	50	0.056
cell motility	GO:0048870	251	0.056	Human
regulation of neuron differentiation	GO:0045664	103	0.056	Human Mouse
phosphorylation	GO:0016310	294	0.056
meiotic chromosome segregation	GO:0045132	59	0.055
positive regulation of neurogenesis	GO:0050769	41	0.055
regulation of apoptotic process	GO:0042981	130	0.055
phosphatidylinositol mediated signaling	GO:0048015	4	0.055
central nervous system development	GO:0007417	201	0.053	Human
single organism catabolic process	GO:0044712	228	0.053	Human
positive regulation of signaling	GO:0023056	243	0.052	Human Mouse
negative regulation of gene expression	GO:0010629	387	0.052	Human
intracellular transport	GO:0046907	228	0.052	Human
microtubule based transport	GO:0010970	42	0.052
apoptotic process	GO:0006915	159	0.051
membrane organization	GO:0061024	112	0.050
regulation of organelle organization	GO:0033043	196	0.050
chemotaxis	GO:0006935	249	0.050	Worm
posttranscriptional regulation of gene expression	GO:0010608	145	0.050
chromatin assembly	GO:0031497	48	0.049
regulation of catabolic process	GO:0009894	170	0.049	Human Mouse
purine ribonucleoside metabolic process	GO:0046128	127	0.049	Human
cilium organization	GO:0044782	41	0.049
purine containing compound catabolic process	GO:0072523	112	0.048	Human
neurotransmitter transport	GO:0006836	37	0.048	Human
epidermis development	GO:0008544	65	0.048
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.048
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.048	Mouse
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.047
protein complex biogenesis	GO:0070271	201	0.047
anatomical structure homeostasis	GO:0060249	97	0.047	Mouse
nucleoside metabolic process	GO:0009116	127	0.046	Human
carbohydrate derivative metabolic process	GO:1901135	217	0.045	Human
purine ribonucleotide catabolic process	GO:0009154	109	0.045	Human
intracellular protein transport	GO:0006886	104	0.044	Human
positive regulation of nervous system development	GO:0051962	69	0.043
cellular response to chemical stimulus	GO:0070887	199	0.043	Human
positive regulation of secretion by cell	GO:1903532	20	0.043
intracellular signal transduction	GO:0035556	300	0.043	Human Mouse
regulation of anatomical structure morphogenesis	GO:0022603	242	0.043	Human Mouse
positive regulation of phosphorus metabolic process	GO:0010562	139	0.043	Human Mouse
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.042	Human
meiotic nuclear division	GO:0007126	151	0.042
regulation of response to dna damage stimulus	GO:2001020	23	0.042
carbohydrate derivative catabolic process	GO:1901136	118	0.042	Human
regulation of protein localization	GO:0032880	76	0.041	Human
endosomal transport	GO:0016197	44	0.040
inorganic cation transmembrane transport	GO:0098662	61	0.040
negative regulation of neurogenesis	GO:0050768	53	0.040
regulation of cellular response to stress	GO:0080135	89	0.040	Human
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.040
spermatogenesis	GO:0007283	200	0.040
mapk cascade	GO:0000165	107	0.039	Human
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.039	Human
positive regulation of response to stimulus	GO:0048584	323	0.039	Human Mouse
organonitrogen compound catabolic process	GO:1901565	128	0.039	Human
purine nucleoside catabolic process	GO:0006152	112	0.039	Human
nucleobase containing small molecule metabolic process	GO:0055086	174	0.039	Human
regulation of anatomical structure size	GO:0090066	163	0.039	Mouse
positive regulation of jun kinase activity	GO:0043507	4	0.038
regulation of protein metabolic process	GO:0051246	256	0.037	Human Mouse
sister chromatid segregation	GO:0000819	92	0.037
cation homeostasis	GO:0055080	51	0.037
necrotic cell death	GO:0070265	1	0.037
forebrain development	GO:0030900	2	0.037	Human
organic cyclic compound catabolic process	GO:1901361	168	0.036	Human
organic substance transport	GO:0071702	257	0.035	Human
dendrite morphogenesis	GO:0048813	199	0.035	Human Mouse
positive regulation of rna biosynthetic process	GO:1902680	266	0.035
cellular ion homeostasis	GO:0006873	39	0.034
positive regulation of organelle organization	GO:0010638	65	0.034
regulation of molecular function	GO:0065009	217	0.033	Human
regulation of synapse assembly	GO:0051963	94	0.033
regulation of developmental growth	GO:0048638	174	0.033
ion transport	GO:0006811	145	0.033
cytoplasmic transport	GO:0016482	130	0.033	Human
vesicle mediated transport	GO:0016192	381	0.033
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.032
positive regulation of cellular component biogenesis	GO:0044089	80	0.032
regulation of phosphate metabolic process	GO:0019220	210	0.032	Human Mouse
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.031
neurotransmitter secretion	GO:0007269	35	0.031	Human
rna processing	GO:0006396	147	0.031
metal ion homeostasis	GO:0055065	44	0.030
establishment or maintenance of cell polarity	GO:0007163	167	0.030
nucleotide catabolic process	GO:0009166	109	0.030	Human
protein modification by small protein conjugation	GO:0032446	79	0.030	Human
male gamete generation	GO:0048232	201	0.030
cell projection assembly	GO:0030031	94	0.029
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.029
cellular response to endogenous stimulus	GO:0071495	80	0.029	Human
negative regulation of growth	GO:0045926	84	0.029
regulation of cell development	GO:0060284	215	0.029	Human Mouse
protein phosphorylation	GO:0006468	169	0.029
gene silencing	GO:0016458	138	0.029
negative regulation of cellular component organization	GO:0051129	108	0.029	Human
regulation of cellular localization	GO:0060341	136	0.028
negative regulation of cell development	GO:0010721	62	0.028
atp catabolic process	GO:0006200	38	0.028
developmental cell growth	GO:0048588	52	0.028	Worm
regulation of gene expression epigenetic	GO:0040029	128	0.028
regulation of protein kinase activity	GO:0045859	51	0.027	Human
digestive system development	GO:0055123	149	0.027
organic acid metabolic process	GO:0006082	103	0.027
embryo development ending in birth or egg hatching	GO:0009792	152	0.027
peptidyl amino acid modification	GO:0018193	105	0.026
positive regulation of cell migration	GO:0030335	2	0.026
eye development	GO:0001654	323	0.026
dorsal closure	GO:0007391	79	0.026
positive regulation of programmed cell death	GO:0043068	62	0.026	Human
head development	GO:0060322	135	0.026	Human
spermatid differentiation	GO:0048515	114	0.026
female meiotic division	GO:0007143	70	0.026
proteolysis	GO:0006508	192	0.025	Mouse
negative regulation of phosphorylation	GO:0042326	35	0.025	Mouse
regulation of cellular catabolic process	GO:0031329	157	0.025	Human Mouse
epithelial cell development	GO:0002064	274	0.025
glycosyl compound catabolic process	GO:1901658	112	0.025	Human
regulation of excitatory postsynaptic membrane potential	GO:0060079	3	0.025	Mouse
regulation of protein modification by small protein conjugation or removal	GO:1903320	25	0.024	Human
positive regulation of cell development	GO:0010720	61	0.024
protein complex assembly	GO:0006461	200	0.024
organelle assembly	GO:0070925	198	0.024
ribonucleoside monophosphate catabolic process	GO:0009158	39	0.024
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.023
positive regulation of intracellular signal transduction	GO:1902533	116	0.023	Human Mouse
mitochondrion degradation	GO:0000422	8	0.023
regulation of synapse organization	GO:0050807	110	0.023
positive regulation of protein modification process	GO:0031401	58	0.023	Human Mouse
regulation of cellular ketone metabolic process	GO:0010565	3	0.023
positive regulation of cell motility	GO:2000147	3	0.023
aging	GO:0007568	143	0.023	Human
cellular protein complex assembly	GO:0043623	71	0.022
establishment of protein localization	GO:0045184	163	0.022	Human
positive regulation of developmental process	GO:0051094	143	0.022
cytokinesis	GO:0000910	90	0.022
regulation of endocytosis	GO:0030100	37	0.021
modification dependent macromolecule catabolic process	GO:0043632	79	0.021	Mouse
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.021	Human
regulation of nucleoside metabolic process	GO:0009118	50	0.021	Human
negative regulation of response to stimulus	GO:0048585	258	0.021	Human
regulation of cell death	GO:0010941	173	0.021	Human
regulation of protein catabolic process	GO:0042176	55	0.021	Mouse
regulation of phosphorylation	GO:0042325	147	0.020	Human Mouse
regulation of synaptic vesicle endocytosis	GO:1900242	7	0.020
calcium ion transport	GO:0006816	24	0.020
localization of cell	GO:0051674	257	0.020	Human
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.020
regulation of response to stress	GO:0080134	200	0.020	Human
purine ribonucleoside monophosphate catabolic process	GO:0009169	38	0.020
positive regulation of transcription dna templated	GO:0045893	266	0.019
response to organic cyclic compound	GO:0014070	89	0.019	Human
phosphatidylinositol 3 kinase signaling	GO:0014065	4	0.019
macromolecule catabolic process	GO:0009057	161	0.018	Mouse
regulation of microtubule cytoskeleton organization	GO:0070507	41	0.018
negative regulation of cell differentiation	GO:0045596	143	0.018
protein polymerization	GO:0051258	42	0.018
negative regulation of organelle organization	GO:0010639	56	0.018	Human
cation transport	GO:0006812	110	0.018
stress activated mapk cascade	GO:0051403	52	0.018
dna packaging	GO:0006323	91	0.018
nitrogen compound transport	GO:0071705	85	0.018
cellular divalent inorganic cation homeostasis	GO:0072503	23	0.018
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.018	Human
epithelium migration	GO:0090132	148	0.018
positive regulation of catalytic activity	GO:0043085	118	0.018	Human
ion transmembrane transport	GO:0034220	122	0.018
chromatin modification	GO:0016568	147	0.018
protein deubiquitination	GO:0016579	17	0.017
negative regulation of developmental process	GO:0051093	201	0.017
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.017	Mouse
vesicle organization	GO:0016050	44	0.017
negative regulation of protein metabolic process	GO:0051248	85	0.017	Human Mouse
membrane fusion	GO:0061025	42	0.017
synaptic vesicle exocytosis	GO:0016079	16	0.017	Human
cellular response to organic substance	GO:0071310	132	0.017	Human
organ growth	GO:0035265	56	0.017
response to endogenous stimulus	GO:0009719	119	0.017	Human
peptidyl tyrosine phosphorylation	GO:0018108	24	0.017	Mouse
actin filament bundle assembly	GO:0051017	26	0.017
regulation of dna metabolic process	GO:0051052	34	0.017
cellular response to nutrient levels	GO:0031669	62	0.017
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.016
terminal button organization	GO:0072553	19	0.016
microtubule polymerization or depolymerization	GO:0031109	39	0.016
modification dependent protein catabolic process	GO:0019941	78	0.016	Mouse
oxidation reduction process	GO:0055114	123	0.016	Human
camera type eye morphogenesis	GO:0048593	2	0.016
microtubule based movement	GO:0007018	51	0.016
response to nitrogen compound	GO:1901698	90	0.016	Human
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.016	Human
nucleoside monophosphate catabolic process	GO:0009125	39	0.016
autophagy	GO:0006914	108	0.016	Human Mouse
endomembrane system organization	GO:0010256	119	0.016
regulation of cell differentiation	GO:0045595	302	0.016	Human Mouse
negative regulation of cellular catabolic process	GO:0031330	34	0.016	Human
translation	GO:0006412	69	0.015
meiotic cell cycle	GO:0051321	171	0.015
response to oxidative stress	GO:0006979	86	0.015	Human Worm
imaginal disc pattern formation	GO:0007447	91	0.015
eye morphogenesis	GO:0048592	260	0.015
sensory organ morphogenesis	GO:0090596	260	0.015
regulation of cellular amine metabolic process	GO:0033238	3	0.015
mrna catabolic process	GO:0006402	33	0.015
protein localization to organelle	GO:0033365	82	0.015	Human
positive regulation of catabolic process	GO:0009896	105	0.015	Human Mouse
regulation of response to oxidative stress	GO:1902882	4	0.015	Human
hindbrain development	GO:0030902	2	0.015
spinal cord development	GO:0021510	1	0.015
positive regulation of molecular function	GO:0044093	136	0.014	Human
positive regulation of synapse assembly	GO:0051965	29	0.014
actin filament based process	GO:0030029	220	0.014
steroid biosynthetic process	GO:0006694	16	0.014
developmental growth involved in morphogenesis	GO:0060560	65	0.014	Worm
regulation of meiosis	GO:0040020	3	0.014
carboxylic acid metabolic process	GO:0019752	92	0.014
heterochromatin organization	GO:0070828	25	0.014
regulation of purine nucleotide catabolic process	GO:0033121	48	0.014	Human
mitotic spindle organization	GO:0007052	220	0.014
small rna loading onto risc	GO:0070922	6	0.014
regulation of protein polymerization	GO:0032271	28	0.013
regulation of synaptic plasticity	GO:0048167	14	0.013
regulation of synaptic activity	GO:0060025	9	0.013
ras protein signal transduction	GO:0007265	88	0.013
blastoderm segmentation	GO:0007350	159	0.013
microtubule depolymerization	GO:0007019	25	0.013
gene silencing by rna	GO:0031047	57	0.013
regulation of intracellular signal transduction	GO:1902531	236	0.013	Human Mouse
production of small rna involved in gene silencing by rna	GO:0070918	15	0.013
regulation of erbb signaling pathway	GO:1901184	42	0.013
regulation of synaptic vesicle transport	GO:1902803	10	0.013
signal transduction by phosphorylation	GO:0023014	107	0.013	Human
regulation of wnt signaling pathway	GO:0030111	68	0.013
mrna processing	GO:0006397	104	0.013
positive regulation of purine nucleotide metabolic process	GO:1900544	55	0.013	Human
regulation of ras protein signal transduction	GO:0046578	93	0.013
purine nucleoside monophosphate catabolic process	GO:0009128	38	0.013
axon extension	GO:0048675	32	0.013	Worm
protein targeting	GO:0006605	64	0.012	Human
imaginal disc derived appendage development	GO:0048737	399	0.012
metal ion transport	GO:0030001	74	0.012
stress activated protein kinase signaling cascade	GO:0031098	55	0.012
response to temperature stimulus	GO:0009266	106	0.012
neuromuscular synaptic transmission	GO:0007274	67	0.012
apoptotic signaling pathway	GO:0097190	27	0.012
cytoskeleton dependent intracellular transport	GO:0030705	44	0.012
columnar cuboidal epithelial cell development	GO:0002066	249	0.012
regulation of cellular component size	GO:0032535	98	0.012
cellular ketone metabolic process	GO:0042180	24	0.012
regulation of cell morphogenesis	GO:0022604	163	0.012	Human Mouse
reproductive system development	GO:0061458	74	0.012
regulation of synaptic vesicle exocytosis	GO:2000300	3	0.012	Human
response to radiation	GO:0009314	155	0.012
regulation of synapse structure and activity	GO:0050803	128	0.012
regulation of protein complex assembly	GO:0043254	42	0.012
regulation of cell substrate adhesion	GO:0010810	2	0.012
carbohydrate derivative biosynthetic process	GO:1901137	85	0.012
positive regulation of protein complex assembly	GO:0031334	22	0.012
oxoacid metabolic process	GO:0043436	103	0.012
regulation of hemocyte proliferation	GO:0035206	37	0.011
ion homeostasis	GO:0050801	55	0.011	Human
negative regulation of catabolic process	GO:0009895	36	0.011	Human
regulation of actin filament bundle assembly	GO:0032231	8	0.011
positive regulation of mapk cascade	GO:0043410	63	0.011	Human
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.011	Mouse
posttranscriptional gene silencing	GO:0016441	46	0.011
secretion	GO:0046903	109	0.011	Human
ameboidal type cell migration	GO:0001667	151	0.011
germline stem cell asymmetric division	GO:0098728	15	0.011
positive regulation of macromolecule metabolic process	GO:0010604	405	0.011	Human Mouse
actin cytoskeleton organization	GO:0030036	206	0.011
extrinsic apoptotic signaling pathway	GO:0097191	1	0.011
regulation of insulin receptor signaling pathway	GO:0046626	17	0.011
mitotic nuclear division	GO:0007067	213	0.011
positive regulation of neuron differentiation	GO:0045666	26	0.011
regulation of organ growth	GO:0046620	42	0.011
sensory perception of smell	GO:0007608	80	0.011
neuron projection guidance	GO:0097485	241	0.011	Worm
regulation of jnk cascade	GO:0046328	40	0.011
embryonic pattern specification	GO:0009880	174	0.011
negative regulation of synaptic growth at neuromuscular junction	GO:0045886	39	0.010
periodic partitioning	GO:0007365	29	0.010
regulation of membrane potential	GO:0042391	35	0.010	Human Mouse
negative regulation of multi organism process	GO:0043901	29	0.010
actin filament organization	GO:0007015	126	0.010
camera type eye development	GO:0043010	4	0.010
dna conformation change	GO:0071103	105	0.010

Lrrk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability	Func Analog Org
nervous system disease	DOID:863	0.023	Human
central nervous system disease	DOID:331	0.023	Human
parkinson s disease	DOID:14330	0.023	Human
synucleinopathy	DOID:0050890	0.023	Human
neurodegenerative disease	DOID:1289	0.023	Human
disease of anatomical entity	DOID:7	0.023	Human

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