IMP: Integrative Multi-species Prediction

Drosophila melanogaster

54 known processes

B52 (Dmel_CG10851)

CG10851 gene product from transcript CG10851-RB

(Aliases: SRp55,l(3)s2249,rrm8,RSp55,SR55,B52/SRp55,B52/dSRp55,dSRp55,Rbp8,CG10851,Dmel\CG10851,E726,MabB52,E(Dfd),RRM8)

Entrez: 41670
FLYBASE: FBgn0004587
UniProtKB: P26686

Process Predictions
Disease Predictions

B52 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
cell death	GO:0008219	279	0.920	Human
mrna metabolic process	GO:0016071	124	0.850
gene silencing	GO:0016458	138	0.782
catabolic process	GO:0009056	409	0.726
establishment of localization in cell	GO:0051649	402	0.700
chromatin assembly	GO:0031497	48	0.665
cellular catabolic process	GO:0044248	372	0.657
heterocycle catabolic process	GO:0046700	166	0.651
positive regulation of cellular protein metabolic process	GO:0032270	118	0.561
posttranscriptional regulation of gene expression	GO:0010608	145	0.551
salivary gland development	GO:0007431	162	0.527
chromatin assembly or disassembly	GO:0006333	52	0.523
rna splicing via transesterification reactions	GO:0000375	73	0.499
positive regulation of macromolecule metabolic process	GO:0010604	405	0.487
intracellular transport	GO:0046907	228	0.484
gland development	GO:0048732	191	0.461
regulation of protein metabolic process	GO:0051246	256	0.455
posttranscriptional gene silencing	GO:0016441	46	0.450
vesicle mediated transport	GO:0016192	381	0.448
rna processing	GO:0006396	147	0.431
cellular macromolecule catabolic process	GO:0044265	136	0.405
nuclear division	GO:0000280	332	0.401
gland morphogenesis	GO:0022612	145	0.399
negative regulation of gene expression epigenetic	GO:0045814	77	0.398
histone acetylation	GO:0016573	38	0.389
endocytosis	GO:0006897	310	0.385
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	23	0.383
regulation of mrna splicing via spliceosome	GO:0048024	64	0.383
regulation of rna splicing	GO:0043484	69	0.378
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.375
regulation of mrna processing	GO:0050684	71	0.367
positive regulation of biosynthetic process	GO:0009891	316	0.360
mitotic nuclear division	GO:0007067	213	0.344
exocrine system development	GO:0035272	162	0.330
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.315
tissue death	GO:0016271	102	0.305
autophagy	GO:0006914	108	0.300
organelle assembly	GO:0070925	198	0.299
macromolecule catabolic process	GO:0009057	161	0.299
regulation of mitotic cell cycle	GO:0007346	190	0.288
mrna processing	GO:0006397	104	0.288
regulation of alternative mrna splicing via spliceosome	GO:0000381	60	0.274
appendage development	GO:0048736	401	0.272
histolysis	GO:0007559	102	0.266
spindle organization	GO:0007051	253	0.264
positive regulation of rna biosynthetic process	GO:1902680	266	0.263
developmental programmed cell death	GO:0010623	138	0.263
regulation of cell differentiation	GO:0045595	302	0.257	Human
macromolecular complex assembly	GO:0065003	256	0.256	Human
positive regulation of gene expression	GO:0010628	290	0.255
internal peptidyl lysine acetylation	GO:0018393	38	0.249
mitotic spindle organization	GO:0007052	220	0.223
mitotic cell cycle checkpoint	GO:0007093	88	0.223
negative regulation of signal transduction	GO:0009968	206	0.221
central nervous system development	GO:0007417	201	0.217
death	GO:0016265	284	0.217	Human
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.217
positive regulation of proteolysis	GO:0045862	52	0.216
induction of programmed cell death by ecdysone	GO:0035078	12	0.211
chromatin silencing	GO:0006342	76	0.208
gene silencing by rna	GO:0031047	57	0.205
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.201
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	73	0.197
regulation of cellular protein metabolic process	GO:0032268	243	0.192
protein dna complex subunit organization	GO:0071824	86	0.189
induction of programmed cell death by hormones	GO:0035081	12	0.184
chemotaxis	GO:0006935	249	0.184
positive regulation of cellular biosynthetic process	GO:0031328	316	0.182
regulation of gene expression epigenetic	GO:0040029	128	0.176
salivary gland morphogenesis	GO:0007435	145	0.175
organic substance catabolic process	GO:1901575	308	0.171
immune system process	GO:0002376	347	0.169	Mouse
posttranscriptional gene silencing by rna	GO:0035194	45	0.164
brain development	GO:0007420	120	0.162
protein localization	GO:0008104	284	0.161
single organism intracellular transport	GO:1902582	207	0.159
neuron projection guidance	GO:0097485	241	0.157
regulation of proteolysis	GO:0030162	87	0.156
cellular nitrogen compound catabolic process	GO:0044270	165	0.149
mitotic cytokinesis	GO:0000281	50	0.149
establishment of organelle localization	GO:0051656	122	0.147
wnt signaling pathway	GO:0016055	98	0.145
positive regulation of protein metabolic process	GO:0051247	128	0.144
histone h4 acetylation	GO:0043967	13	0.137
aromatic compound catabolic process	GO:0019439	166	0.137
positive regulation of endopeptidase activity	GO:0010950	26	0.134
regulation of wnt signaling pathway	GO:0030111	68	0.131
negative regulation of cell communication	GO:0010648	223	0.131
rna splicing	GO:0008380	83	0.128
regulation of immune effector process	GO:0002697	52	0.124
epithelial cell differentiation	GO:0030855	322	0.124	Human
male gamete generation	GO:0048232	201	0.120	Worm
positive regulation of developmental process	GO:0051094	143	0.119	Human Worm
regulation of mrna metabolic process	GO:1903311	72	0.118
regulation of cysteine type endopeptidase activity	GO:2000116	27	0.110
response to external biotic stimulus	GO:0043207	293	0.109
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.108	Human
organic substance transport	GO:0071702	257	0.108
rna interference	GO:0016246	27	0.107
negative regulation of developmental process	GO:0051093	201	0.105	Human
cell fate specification	GO:0001708	71	0.105
mitotic dna integrity checkpoint	GO:0044774	75	0.105
negative regulation of signaling	GO:0023057	219	0.101
regulation of catalytic activity	GO:0050790	185	0.101
ecdysone mediated induction of salivary gland cell autophagic cell death	GO:0035072	12	0.100
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.100
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.100
retina development in camera type eye	GO:0060041	4	0.099
induction of programmed cell death	GO:0012502	12	0.095
purine ribonucleoside metabolic process	GO:0046128	127	0.094
positive regulation of transcription dna templated	GO:0045893	266	0.094
positive regulation of catalytic activity	GO:0043085	118	0.094
organonitrogen compound metabolic process	GO:1901564	318	0.092
negative regulation of response to stimulus	GO:0048585	258	0.091
regulation of mitosis	GO:0007088	56	0.091
mrna splicing via spliceosome	GO:0000398	73	0.088
chromatin remodeling	GO:0006338	72	0.087
transcription from rna polymerase ii promoter	GO:0006366	368	0.087
nucleobase containing compound catabolic process	GO:0034655	165	0.086
negative regulation of cellular metabolic process	GO:0031324	382	0.086	Human
cellular response to dna damage stimulus	GO:0006974	223	0.084
chromatin modification	GO:0016568	147	0.083
regulation of cell development	GO:0060284	215	0.082
regulation of cell death	GO:0010941	173	0.082	Human
regulation of endopeptidase activity	GO:0052548	36	0.080
salivary gland cell autophagic cell death	GO:0035071	83	0.079
cellular amine metabolic process	GO:0044106	12	0.078
phagocytosis	GO:0006909	215	0.077
regulation of cell fate commitment	GO:0010453	29	0.077
axon development	GO:0061564	297	0.077
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.076
regulation of catabolic process	GO:0009894	170	0.076
rna catabolic process	GO:0006401	37	0.076
spermatogenesis	GO:0007283	200	0.075	Worm
regulation of phosphate metabolic process	GO:0019220	210	0.074
forebrain development	GO:0030900	2	0.074
positive regulation of response to stimulus	GO:0048584	323	0.074
ncrna metabolic process	GO:0034660	43	0.072
organelle fission	GO:0048285	340	0.071
negative regulation of gene expression	GO:0010629	387	0.070	Human
regulation of protein modification process	GO:0031399	112	0.070
nucleoside triphosphate metabolic process	GO:0009141	120	0.070
regulation of phosphorus metabolic process	GO:0051174	210	0.070
regulation of chromatin organization	GO:1902275	32	0.070
eye development	GO:0001654	323	0.069
regulation of cell cycle	GO:0051726	291	0.069	Rat
negative regulation of cell cycle process	GO:0010948	109	0.069
negative regulation of protein maturation	GO:1903318	31	0.068
regulation of nervous system development	GO:0051960	248	0.067
cellular response to oxygen containing compound	GO:1901701	79	0.067
phosphorylation	GO:0016310	294	0.067
regionalization	GO:0003002	416	0.066
nucleosome mobilization	GO:0042766	9	0.065
cellular response to chemical stimulus	GO:0070887	199	0.065
dna packaging	GO:0006323	91	0.065
salivary gland histolysis	GO:0035070	88	0.064
nucleotide metabolic process	GO:0009117	161	0.064
response to abiotic stimulus	GO:0009628	341	0.064
chromosome separation	GO:0051304	42	0.064
autophagic cell death	GO:0048102	83	0.063
canonical wnt signaling pathway	GO:0060070	21	0.063
positive regulation of rna metabolic process	GO:0051254	271	0.063
programmed cell death	GO:0012501	257	0.062
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.062
protein complex assembly	GO:0006461	200	0.062
alternative mrna splicing via spliceosome	GO:0000380	60	0.061
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.061
peptidyl lysine acetylation	GO:0018394	39	0.060
axonogenesis	GO:0007409	290	0.059
dna conformation change	GO:0071103	105	0.059
proteolysis	GO:0006508	192	0.059
cellular amino acid metabolic process	GO:0006520	61	0.058
establishment of protein localization	GO:0045184	163	0.058
apoptotic process	GO:0006915	159	0.056
negative regulation of cell differentiation	GO:0045596	143	0.056	Human
cellular protein localization	GO:0034613	160	0.055
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.055
negative regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032435	16	0.055
protein complex biogenesis	GO:0070271	201	0.054
amine metabolic process	GO:0009308	12	0.054
imaginal disc derived appendage development	GO:0048737	399	0.054
protein maturation	GO:0051604	71	0.053
imaginal disc derived wing morphogenesis	GO:0007476	337	0.053
axon guidance	GO:0007411	233	0.053
regulation of gene silencing	GO:0060968	63	0.052
cytoplasmic transport	GO:0016482	130	0.051
regulation of chromosome organization	GO:0033044	64	0.051
protein processing	GO:0016485	68	0.050
olfactory behavior	GO:0042048	97	0.049
negative regulation of protein processing	GO:0010955	31	0.049
regulation of cellular ketone metabolic process	GO:0010565	3	0.049
mitotic cell cycle phase transition	GO:0044772	138	0.048
cell migration	GO:0016477	238	0.048
dna integrity checkpoint	GO:0031570	81	0.048
cell division	GO:0051301	248	0.047
regulation of cell cycle phase transition	GO:1901987	130	0.047
chromatin organization	GO:0006325	207	0.047
positive regulation of molecular function	GO:0044093	136	0.047
internal protein amino acid acetylation	GO:0006475	38	0.047
negative regulation of proteolysis involved in cellular protein catabolic process	GO:1903051	17	0.046
nucleus organization	GO:0006997	45	0.046
regulation of cellular response to stress	GO:0080135	89	0.044
cell motility	GO:0048870	251	0.044
positive regulation of hydrolase activity	GO:0051345	78	0.044
protein modification process	GO:0036211	438	0.044
cellular macromolecular complex assembly	GO:0034622	153	0.044	Human
ras protein signal transduction	GO:0007265	88	0.044
response to biotic stimulus	GO:0009607	294	0.043
regulation of multicellular organismal development	GO:2000026	414	0.043	Human Worm
nucleoside phosphate metabolic process	GO:0006753	162	0.043
gtp metabolic process	GO:0046039	72	0.042
response to organic substance	GO:0010033	284	0.042
regulation of organ morphogenesis	GO:2000027	78	0.042	Human
ribose phosphate metabolic process	GO:0019693	145	0.042
regulation of immune system process	GO:0002682	176	0.041
compound eye development	GO:0048749	307	0.041
cognition	GO:0050890	141	0.041
compound eye morphogenesis	GO:0001745	249	0.040
mrna splice site selection	GO:0006376	1	0.040	Human
single organism nuclear import	GO:1902593	51	0.040
regulation of cellular catabolic process	GO:0031329	157	0.040
nucleocytoplasmic transport	GO:0006913	72	0.038
negative regulation of biosynthetic process	GO:0009890	277	0.038
positive regulation of cell death	GO:0010942	69	0.038
nucleosome organization	GO:0034728	59	0.038
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.037
histone h3 acetylation	GO:0043966	11	0.037
regulation of phosphorylation	GO:0042325	147	0.037
activation of cysteine type endopeptidase activity	GO:0097202	17	0.036
head development	GO:0060322	135	0.036
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.035
cytoskeleton dependent cytokinesis	GO:0061640	81	0.035
ribonucleoprotein complex biogenesis	GO:0022613	31	0.035	Human
developmental pigmentation	GO:0048066	68	0.034
positive regulation of cell differentiation	GO:0045597	64	0.034
regulation of molecular function	GO:0065009	217	0.034
positive regulation of signaling	GO:0023056	243	0.034
intracellular protein transport	GO:0006886	104	0.033
appendage morphogenesis	GO:0035107	397	0.033
regulation of cellular amine metabolic process	GO:0033238	3	0.032
regulation of response to stress	GO:0080134	200	0.032	Human
covalent chromatin modification	GO:0016569	106	0.032
development of primary sexual characteristics	GO:0045137	50	0.032	Worm
chromosome organization	GO:0051276	360	0.032
regulation of cellular amino acid metabolic process	GO:0006521	0	0.031
taxis	GO:0042330	304	0.031
mitotic g2 m transition checkpoint	GO:0044818	70	0.031
mitotic dna damage checkpoint	GO:0044773	74	0.031
positive regulation of peptidase activity	GO:0010952	29	0.030
protein modification by small protein removal	GO:0070646	28	0.030
purine nucleoside metabolic process	GO:0042278	127	0.030
negative regulation of mitotic cell cycle	GO:0045930	109	0.030
regulation of multi organism process	GO:0043900	131	0.029
muscle structure development	GO:0061061	224	0.029
purine ribonucleotide catabolic process	GO:0009154	109	0.029
dna damage checkpoint	GO:0000077	78	0.029
regulation of neurogenesis	GO:0050767	158	0.029
regulation of cellular protein catabolic process	GO:1903362	44	0.029
small molecule metabolic process	GO:0044281	305	0.028
regulation of protein catabolic process	GO:0042176	55	0.028
regulation of anatomical structure morphogenesis	GO:0022603	242	0.028	Human
intracellular steroid hormone receptor signaling pathway	GO:0030518	12	0.028
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.028
regulation of cellular localization	GO:0060341	136	0.028
purine containing compound metabolic process	GO:0072521	155	0.028
macromolecular complex disassembly	GO:0032984	37	0.028
protein acetylation	GO:0006473	39	0.028
morphogenesis of a polarized epithelium	GO:0001738	93	0.028
sex differentiation	GO:0007548	81	0.027	Worm
dna metabolic process	GO:0006259	227	0.027
regulation of organelle organization	GO:0033043	196	0.027
ribosome biogenesis	GO:0042254	8	0.027
small gtpase mediated signal transduction	GO:0007264	88	0.027
modification dependent protein catabolic process	GO:0019941	78	0.027
regulation of chromosome segregation	GO:0051983	32	0.027
protein catabolic process	GO:0030163	101	0.027
translational initiation	GO:0006413	11	0.027
positive regulation of cell communication	GO:0010647	250	0.026
reproductive system development	GO:0061458	74	0.026	Worm
protein acylation	GO:0043543	42	0.026
localization of cell	GO:0051674	257	0.026
nucleoside phosphate catabolic process	GO:1901292	110	0.025
multi organism behavior	GO:0051705	175	0.025
ribonucleoside metabolic process	GO:0009119	127	0.025
biological adhesion	GO:0022610	138	0.025
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.024
dna endoreduplication	GO:0042023	22	0.024
eye morphogenesis	GO:0048592	260	0.024
organophosphate metabolic process	GO:0019637	195	0.024
glycosyl compound metabolic process	GO:1901657	127	0.024
regulation of peptidase activity	GO:0052547	39	0.024
negative regulation of cell cycle phase transition	GO:1901988	103	0.024
actin cytoskeleton organization	GO:0030036	206	0.024
cellular protein catabolic process	GO:0044257	83	0.024
genitalia development	GO:0048806	26	0.024	Worm
regulation of proteasomal protein catabolic process	GO:0061136	39	0.024
retina morphogenesis in camera type eye	GO:0060042	2	0.023
positive regulation of phosphate metabolic process	GO:0045937	139	0.023
g2 dna damage checkpoint	GO:0031572	69	0.023
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.023
peptidyl lysine modification	GO:0018205	57	0.023
ribonucleoside catabolic process	GO:0042454	112	0.023
nucleosome assembly	GO:0006334	35	0.022
cytokinesis	GO:0000910	90	0.022
ribonucleotide catabolic process	GO:0009261	109	0.022
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.021
histone modification	GO:0016570	106	0.021
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.021
sensory organ morphogenesis	GO:0090596	260	0.021
limb development	GO:0060173	1	0.021
positive regulation of cell development	GO:0010720	61	0.021
nucleoside metabolic process	GO:0009116	127	0.020
positive regulation of cysteine type endopeptidase activity	GO:2001056	24	0.020
organic cyclic compound catabolic process	GO:1901361	168	0.020
negative regulation of chromosome segregation	GO:0051985	14	0.020
response to ecdysone	GO:0035075	34	0.020
negative regulation of proteasomal protein catabolic process	GO:1901799	16	0.020
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.020
purine ribonucleotide metabolic process	GO:0009150	145	0.020
positive regulation of growth	GO:0045927	75	0.019
negative regulation of catabolic process	GO:0009895	36	0.019
positive regulation of signal transduction	GO:0009967	223	0.019
protein phosphorylation	GO:0006468	169	0.019
neural retina development	GO:0003407	4	0.019
mitotic g2 dna damage checkpoint	GO:0007095	69	0.018
regulation of mitotic sister chromatid separation	GO:0010965	28	0.018
single organism cellular localization	GO:1902580	180	0.018
ncrna processing	GO:0034470	30	0.018
regulation of growth	GO:0040008	233	0.018	Worm
response to other organism	GO:0051707	293	0.018
positive regulation of translation	GO:0045727	12	0.018
regulation of cell cycle process	GO:0010564	181	0.018
regulation of hydrolase activity	GO:0051336	97	0.017
cellular response to decreased oxygen levels	GO:0036294	30	0.017
exocytosis	GO:0006887	28	0.017
cellular component disassembly	GO:0022411	46	0.017
regulation of notch signaling pathway	GO:0008593	100	0.017
dorsal ventral pattern formation	GO:0009953	133	0.017
regulation of translation	GO:0006417	56	0.016
spermatid differentiation	GO:0048515	114	0.016
muscle organ development	GO:0007517	127	0.016
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.016
purine nucleotide metabolic process	GO:0006163	146	0.016
negative regulation of rna biosynthetic process	GO:1902679	240	0.016
guanosine containing compound metabolic process	GO:1901068	74	0.016
camera type eye development	GO:0043010	4	0.016
mapk cascade	GO:0000165	107	0.016
dendrite development	GO:0016358	204	0.016
nucleobase containing small molecule metabolic process	GO:0055086	174	0.016
cell cycle checkpoint	GO:0000075	95	0.016
apoptotic signaling pathway	GO:0097190	27	0.016
positive regulation of mapk cascade	GO:0043410	63	0.015
regulation of intracellular signal transduction	GO:1902531	236	0.015
regulation of protein processing	GO:0070613	32	0.015
meiotic nuclear division	GO:0007126	151	0.015
branch fusion open tracheal system	GO:0035147	17	0.015
protein dna complex assembly	GO:0065004	63	0.015
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.015
regulation of chromatin silencing	GO:0031935	36	0.015
regulation of heterochromatin assembly	GO:0031445	8	0.015
positive regulation of intracellular signal transduction	GO:1902533	116	0.014
body morphogenesis	GO:0010171	2	0.014	Worm
hindbrain development	GO:0030902	2	0.014
telencephalon development	GO:0021537	2	0.014
positive regulation of multi organism process	GO:0043902	40	0.014
glycosyl compound catabolic process	GO:1901658	112	0.014
negative regulation of cell cycle	GO:0045786	116	0.014
regulation of ras protein signal transduction	GO:0046578	93	0.014
ameboidal type cell migration	GO:0001667	151	0.014
negative regulation of protein catabolic process	GO:0042177	17	0.014
camera type eye morphogenesis	GO:0048593	2	0.014
gonad development	GO:0008406	50	0.013	Worm
nucleoside triphosphate catabolic process	GO:0009143	108	0.013
meiotic cell cycle process	GO:1903046	132	0.013
membrane organization	GO:0061024	112	0.013
nucleotide catabolic process	GO:0009166	109	0.013
positive regulation of nervous system development	GO:0051962	69	0.013
pupal development	GO:0035209	11	0.013
purine nucleoside catabolic process	GO:0006152	112	0.013
positive regulation of cellular amine metabolic process	GO:0033240	0	0.013
regulation of programmed cell death	GO:0043067	152	0.013
single organism carbohydrate metabolic process	GO:0044723	72	0.013
purine nucleotide catabolic process	GO:0006195	109	0.013
carbohydrate derivative catabolic process	GO:1901136	118	0.012
response to sterol	GO:0036314	34	0.012
golgi vesicle transport	GO:0048193	27	0.012
carboxylic acid metabolic process	GO:0019752	92	0.012
developmental growth	GO:0048589	280	0.012
carbohydrate metabolic process	GO:0005975	82	0.012
guanosine containing compound catabolic process	GO:1901069	74	0.012
antimicrobial humoral response	GO:0019730	99	0.012
chemosensory behavior	GO:0007635	106	0.012
single organism catabolic process	GO:0044712	228	0.012
regulation of meiosis	GO:0040020	3	0.012
chromosome segregation	GO:0007059	157	0.012
memory	GO:0007613	94	0.012
convergent extension	GO:0060026	2	0.011
regulation of chromatin modification	GO:1903308	28	0.011
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.011
protein heterooligomerization	GO:0051291	4	0.011
eye photoreceptor cell differentiation	GO:0001754	145	0.011
negative regulation of cellular catabolic process	GO:0031330	34	0.011
regulation of localization	GO:0032879	275	0.011
organic acid metabolic process	GO:0006082	103	0.011
tube fusion	GO:0035146	17	0.011
protein transport	GO:0015031	155	0.011
negative regulation of proteolysis	GO:0045861	31	0.011
cell cycle dna replication	GO:0044786	23	0.011
neuron fate commitment	GO:0048663	50	0.011
negative regulation of rna metabolic process	GO:0051253	251	0.011	Human
histone h4 k16 acetylation	GO:0043984	4	0.011
cell fate determination	GO:0001709	91	0.011
single organism behavior	GO:0044708	391	0.011
cellular ketone metabolic process	GO:0042180	24	0.011
transcription from rna polymerase iii promoter	GO:0006383	8	0.011
multicellular organismal reproductive behavior	GO:0033057	110	0.011
modification dependent macromolecule catabolic process	GO:0043632	79	0.010
regulation of protein maturation	GO:1903317	32	0.010
nuclear body organization	GO:0030575	6	0.010
establishment of protein localization to organelle	GO:0072594	62	0.010
spermatid development	GO:0007286	98	0.010
meiosis i	GO:0007127	59	0.010
regulation of response to biotic stimulus	GO:0002831	63	0.010

B52 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.036
nervous system disease	DOID:863	0.036
disease of cellular proliferation	DOID:14566	0.027

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