Drosophila melanogaster

173 known processes

R (Dmel_CG1956)

Roughened

(Aliases: rap1,Dras3,Dras62B,l(3)62Bf,DRap,RasIII,RAP1,CG1956,l(3)R,ras3,Dmel\CG1956,BEST:GH18528,ras 3,C-ras3,Ras3,Rap,DRap1,E(faf),Rap1,D-Rap1)

R biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
ovarian follicle cell migrationGO:00072971210.984
embryonic development via the syncytial blastodermGO:00017001480.939
dorsal closureGO:0007391790.914
border follicle cell migrationGO:00072981130.882
tissue morphogenesisGO:00487292970.848
wing disc morphogenesisGO:00074723440.755
embryonic hemopoiesisGO:0035162260.735
tissue migrationGO:00901301550.726
photoreceptor cell differentiationGO:00465301700.703
epithelium migrationGO:00901321480.681
compound eye developmentGO:00487493070.617
establishment of ommatidial planar polarityGO:0042067490.588
purine ribonucleoside metabolic processGO:00461281270.509
embryonic morphogenesisGO:00485982060.499
compound eye photoreceptor developmentGO:0042051780.449
epithelial cell migrationGO:00106311480.390
negative regulation of cell communicationGO:00106482230.349
Mouse
morphogenesis of a polarized epitheliumGO:0001738930.335
oocyte differentiationGO:00099941450.329
embryo development ending in birth or egg hatchingGO:00097921520.291
imaginal disc derived appendage developmentGO:00487373990.278
photoreceptor cell developmentGO:0042461960.257
regulation of phosphate metabolic processGO:00192202100.251
Mouse Rat
eye morphogenesisGO:00485922600.248
morphogenesis of an epitheliumGO:00020092760.245
r7 cell differentiationGO:0045466430.244
regulation of catabolic processGO:00098941700.236
Rat
eye photoreceptor cell developmentGO:0042462810.232
catabolic processGO:00090564090.224
imaginal disc derived wing morphogenesisGO:00074763370.219
organic substance catabolic processGO:19015753080.189
purine nucleoside triphosphate catabolic processGO:00091461080.176
oocyte axis specificationGO:00073091080.176
positive regulation of macromolecule metabolic processGO:00106044050.173
Rat
purine nucleoside metabolic processGO:00422781270.173
axis specificationGO:00097981670.172
Zebrafish
oocyte constructionGO:00073081120.172
positive regulation of nitrogen compound metabolic processGO:00511733540.171
Rat
cellular response to nutrient levelsGO:0031669620.170
post embryonic appendage morphogenesisGO:00351203850.165
carbohydrate derivative catabolic processGO:19011361180.165
compound eye photoreceptor cell differentiationGO:00017511400.160
ribonucleoside metabolic processGO:00091191270.157
cation transportGO:00068121100.156
regulation of hemocyte differentiationGO:0045610220.154
response to organic cyclic compoundGO:0014070890.152
Human
cell maturationGO:00484691440.144
morphogenesis of follicular epitheliumGO:0016333360.143
regulation of cytoskeleton organizationGO:0051493890.137
germarium derived egg chamber formationGO:00072931010.136
purine ribonucleoside triphosphate metabolic processGO:00092051190.134
head involutionGO:0008258350.129
regulation of cell proliferationGO:00421271630.126
gastrulationGO:0007369700.125
gtp metabolic processGO:0046039720.112
cell recognitionGO:00080371020.109
regulation of cell differentiationGO:00455953020.108
r7 cell fate commitmentGO:0007465120.106
cellular catabolic processGO:00442483720.103
regulation of protein serine threonine kinase activityGO:0071900250.102
homeostatic processGO:00425921990.098
ameboidal type cell migrationGO:00016671510.091
regulation of cellular catabolic processGO:00313291570.091
Rat
purine nucleoside catabolic processGO:00061521120.091
membrane invaginationGO:0010324110.090
ovarian follicle cell developmentGO:00307072480.086
digestive tract morphogenesisGO:00485461270.084
signal transduction downstream of smoothenedGO:000722750.083
appendage morphogenesisGO:00351073970.080
second mitotic wave involved in compound eye morphogenesisGO:001633070.076
purine nucleotide catabolic processGO:00061951090.076
nucleoside triphosphate metabolic processGO:00091411200.075
cellular response to starvationGO:0009267610.074
compound eye morphogenesisGO:00017452490.074
positive regulation of cellular catabolic processGO:0031331950.072
Rat
negative regulation of homeostatic processGO:003284520.072
phagocytosis engulfmentGO:0006911110.071
ovarian follicle cell stalk formationGO:0030713170.071
adherens junction organizationGO:0034332270.071
regulation of protein kinase activityGO:0045859510.071
Rat
positive regulation of protein phosphorylationGO:0001934340.069
Rat
gtp catabolic processGO:0006184720.068
rho protein signal transductionGO:0007266140.067
regulation of cell developmentGO:00602842150.067
Mouse Rat
intracellular signal transductionGO:00355563000.065
ras protein signal transductionGO:0007265880.063
dna replicationGO:0006260480.060
hemocyte differentiationGO:0042386380.059
r7 cell developmentGO:0045467140.058
wound healingGO:0042060750.056
guanosine containing compound catabolic processGO:1901069740.056
regulation of apoptotic processGO:00429811300.055
regulation of tube architecture open tracheal systemGO:0035152680.053
regulation of cell morphogenesisGO:00226041630.053
kidney developmentGO:000182230.053
regulation of immune system processGO:00026821760.053
compound eye cone cell differentiationGO:0042675130.053
carbohydrate derivative metabolic processGO:19011352170.052
epidermal growth factor receptor signaling pathwayGO:0007173580.052
response to nitrogen compoundGO:1901698900.052
Human
regulation of phosphorus metabolic processGO:00511742100.051
Mouse Rat
regulation of epidermal growth factor receptor signaling pathwayGO:0042058420.050
eye developmentGO:00016543230.049
regulation of hormone levelsGO:0010817400.049
eye photoreceptor cell differentiationGO:00017541450.049
negative regulation of cellular metabolic processGO:00313243820.049
mapk cascadeGO:00001651070.046
Mouse Rat
positive regulation of transferase activityGO:0051347260.046
Rat
regulation of transferase activityGO:0051338580.045
Rat
cell divisionGO:00513012480.045
endodermal cell fate commitmentGO:000171130.045
establishment of planar polarityGO:0001736870.045
hemocyte migrationGO:0035099190.044
immune system processGO:00023763470.043
regionalizationGO:00030024160.042
Zebrafish
developmental maturationGO:00217001720.041
oocyte localization involved in germarium derived egg chamber formationGO:0030720120.041
regulation of embryonic developmentGO:0045995680.040
regulation of ras protein signal transductionGO:0046578930.040
Rat
dorsal ventral axis specification ovarian follicular epitheliumGO:0008069130.040
micropyle formationGO:004684440.040
chemical homeostasisGO:0048878920.040
positive regulation of phosphorylationGO:0042327870.039
Mouse Rat
epithelial cell developmentGO:00020642740.039
Human
small gtpase mediated signal transductionGO:0007264880.039
oocyte developmentGO:00485991240.038
tube developmentGO:00352952440.038
cellular nitrogen compound catabolic processGO:00442701650.038
embryonic organ developmentGO:0048568500.038
anatomical structure homeostasisGO:0060249970.037
open tracheal system developmentGO:00074242040.037
digestive system developmentGO:00551231490.037
regulation of cyclin dependent protein serine threonine kinase activityGO:000007930.036
response to other organismGO:00517072930.035
positive regulation of nucleotide metabolic processGO:0045981550.035
Rat
cellular ketone metabolic processGO:0042180240.035
cuticle developmentGO:0042335860.035
Worm
glycosyl compound metabolic processGO:19016571270.035
gland developmentGO:00487321910.034
embryonic pattern specificationGO:00098801740.034
Zebrafish
ribonucleotide metabolic processGO:00092591450.034
regulation of cellular response to stressGO:0080135890.034
morphogenesis of embryonic epitheliumGO:0016331940.034
ommatidial rotationGO:0016318200.034
chitin based embryonic cuticle biosynthetic processGO:0008362160.033
appendage developmentGO:00487364010.033
purine containing compound metabolic processGO:00725211550.033
purine ribonucleotide metabolic processGO:00091501450.033
regulation of gtpase activityGO:0043087440.033
Rat
compound eye retinal cell programmed cell deathGO:0046667230.032
negative regulation of erk1 and erk2 cascadeGO:007037330.032
response to woundingGO:0009611940.032
regulation of map kinase activityGO:0043405170.032
response to endogenous stimulusGO:00097191190.031
Human Rat
protein catabolic processGO:00301631010.031
immune responseGO:00069552460.030
jnk cascadeGO:0007254500.030
maintenance of protein location in cellGO:0032507260.030
digestive tract developmentGO:00485651490.029
purine nucleoside triphosphate metabolic processGO:00091441190.029
energy derivation by oxidation of organic compoundsGO:0015980320.029
columnar cuboidal epithelial cell differentiationGO:00020652560.029
germarium derived female germ line cyst encapsulationGO:003070880.028
regulation of kinase activityGO:0043549530.028
Rat
cellular component assembly involved in morphogenesisGO:00109271510.028
ion homeostasisGO:0050801550.027
nucleoside phosphate metabolic processGO:00067531620.027
regulation of mapk cascadeGO:0043408920.027
Mouse Rat
regulation of phosphorylationGO:00423251470.027
Mouse Rat
axon developmentGO:00615642970.026
cellular response to organic substanceGO:00713101320.026
Human Rat
cortical actin cytoskeleton organizationGO:0030866240.026
imaginal disc derived appendage morphogenesisGO:00351143950.026
establishment of tissue polarityGO:0007164870.026
regulation of developmental growthGO:00486381740.025
regulation of proteasomal protein catabolic processGO:0061136390.025
regulation of rho protein signal transductionGO:0035023200.025
blastoderm segmentationGO:00073501590.025
positive regulation of cell differentiationGO:0045597640.025
Mouse Rat
dephosphorylationGO:0016311510.025
purine ribonucleotide catabolic processGO:00091541090.025
establishment or maintenance of bipolar cell polarityGO:0061245340.025
epithelial cell cell adhesionGO:009013660.024
negative regulation of protein depolymerizationGO:1901880230.024
cuticle pattern formationGO:0035017270.024
eggshell chorion assemblyGO:0007306660.024
regulation of protein catabolic processGO:0042176550.023
negative regulation of cellular biosynthetic processGO:00313272770.023
chaeta morphogenesisGO:0008407420.022
columnar cuboidal epithelial cell developmentGO:00020662490.022
dorsal closure spreading of leading edge cellsGO:000739540.022
regulation of viral genome replicationGO:004506940.022
cellular response to extracellular stimulusGO:0031668640.022
developmental growthGO:00485892800.022
reproductive system developmentGO:0061458740.021
tube morphogenesisGO:00352391910.021
cellular macromolecule localizationGO:00707272200.021
maintenance of apical basal cell polarityGO:003509080.021
response to abiotic stimulusGO:00096283410.020
cellular homeostasisGO:0019725800.020
regulation of intracellular signal transductionGO:19025312360.020
Mouse Rat
regulation of ras gtpase activityGO:0032318380.020
Rat
negative regulation of cellular protein metabolic processGO:0032269850.020
positive regulation of mitotic cell cycleGO:0045931340.020
regulation of catalytic activityGO:00507901850.019
Rat
epithelial cell differentiationGO:00308553220.019
Human
positive regulation of protein kinase activityGO:0045860250.019
Rat
negative regulation of response to stimulusGO:00485852580.019
heterocycle catabolic processGO:00467001660.019
asymmetric cell divisionGO:0008356370.019
regulation of rho gtpase activityGO:0032319200.019
positive regulation of catalytic activityGO:00430851180.019
Rat
regulation of cell cycleGO:00517262910.019
sensory organ morphogenesisGO:00905962600.019
negative regulation of epidermal growth factor receptor signaling pathwayGO:0042059290.019
regulation of compound eye retinal cell programmed cell deathGO:0046669180.019
positive regulation of nervous system developmentGO:0051962690.019
Mouse Rat
regulation of purine nucleotide catabolic processGO:0033121480.019
Rat
activation of protein kinase activityGO:0032147120.018
regulation of vesicle mediated transportGO:0060627590.018
Mouse
regulation of erk1 and erk2 cascadeGO:0070372390.018
Mouse Rat
developmental programmed cell deathGO:00106231380.018
negative regulation of wnt signaling pathwayGO:0030178280.018
nucleotide catabolic processGO:00091661090.018
organophosphate metabolic processGO:00196371950.018
positive regulation of catabolic processGO:00098961050.017
Rat
guanosine containing compound metabolic processGO:1901068740.017
positive regulation of protein serine threonine kinase activityGO:0071902150.017
organonitrogen compound metabolic processGO:19015643180.017
compound eye photoreceptor fate commitmentGO:0001752360.017
peptidyl threonine phosphorylationGO:001810720.017
eye antennal disc morphogenesisGO:0007455340.017
regulation of protein modification processGO:00313991120.017
Rat
nucleoside phosphate catabolic processGO:19012921100.017
protein phosphorylationGO:00064681690.016
Rat
establishment or maintenance of epithelial cell apical basal polarityGO:0045197240.016
regulation of protein metabolic processGO:00512462560.016
Rat
positive regulation of epithelial cell differentiationGO:003085810.016
positive regulation of nucleotide catabolic processGO:0030813460.016
Rat
hemopoiesisGO:0030097460.016
positive regulation of signalingGO:00230562430.016
Mouse Rat
negative regulation of signal transductionGO:00099682060.016
negative regulation of rna metabolic processGO:00512532510.016
positive regulation of response to stimulusGO:00485843230.015
Mouse Rat
nucleotide metabolic processGO:00091171610.015
establishment or maintenance of polarity of follicular epitheliumGO:0016334260.015
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.015
dorsal appendage formationGO:0046843470.015
regulation of response to external stimulusGO:00321011150.015
nucleoside metabolic processGO:00091161270.015
regulation of cell shapeGO:00083601130.015
response to organophosphorusGO:004668320.015
Human
segmentationGO:00352822070.015
Zebrafish
neuron recognitionGO:00080381010.015
regulation of cellular amino acid metabolic processGO:000652100.015
erk1 and erk2 cascadeGO:0070371390.014
Mouse Rat
response to organonitrogen compoundGO:0010243750.014
Human
organic cyclic compound catabolic processGO:19013611680.014
regulation of nucleotide catabolic processGO:0030811480.014
Rat
nucleoside catabolic processGO:00091641120.014
negative regulation of protein metabolic processGO:0051248850.014
cell proliferationGO:00082832990.014
Mouse
positive regulation of gene expressionGO:00106282900.014
activation of jun kinase activityGO:000725730.014
purine containing compound catabolic processGO:00725231120.014
negative regulation of signalingGO:00230572190.014
Mouse
oocyte microtubule cytoskeleton polarizationGO:0008103220.014
hematopoietic or lymphoid organ developmentGO:0048534570.013
positive regulation of cell proliferationGO:0008284470.013
germ line cyst formationGO:0048134440.013
positive regulation of intracellular signal transductionGO:19025331160.013
Mouse Rat
establishment or maintenance of apical basal cell polarityGO:0035088340.013
dorsal ventral pattern formationGO:00099531330.013
single organism catabolic processGO:00447122280.013
regulation of notch signaling pathwayGO:00085931000.013
positive regulation of r7 cell differentiationGO:004567870.013
leg disc developmentGO:0035218920.013
positive regulation of nucleoside metabolic processGO:0045979470.013
Rat
ion transportGO:00068111450.012
negative regulation of autophagyGO:0010507160.012
gastrulation involving germ band extensionGO:0010004360.012
translationGO:0006412690.012
regulation of microtubule cytoskeleton organizationGO:0070507410.012
negative regulation of signal transduction by p53 class mediatorGO:190179710.012
salivary gland morphogenesisGO:00074351450.012
regulation of nervous system developmentGO:00519602480.012
Mouse Rat
convergent extension involved in gastrulationGO:006002720.012
negative regulation of protein phosphorylationGO:0001933170.012
cellular macromolecular complex assemblyGO:00346221530.012
ribonucleoside triphosphate catabolic processGO:00092031080.012
adherens junction assemblyGO:0034333110.012
cytoplasmic transportGO:00164821300.012
attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregationGO:005131610.012
positive regulation of gtpase activityGO:0043547430.012
Rat
morphogenesis of a branching epitheliumGO:0061138450.012
signal transduction by phosphorylationGO:00230141070.012
Mouse Rat
positive regulation of ras gtpase activityGO:0032320360.012
Rat
regulation of transportGO:00510491810.012
Mouse
respiratory system developmentGO:00605412130.012
cellular macromolecule catabolic processGO:00442651360.012
cell projection assemblyGO:0030031940.011
vesicle mediated transportGO:00161923810.011
Mouse
stress activated mapk cascadeGO:0051403520.011
regulation of hydrolase activityGO:0051336970.011
Rat
positive regulation of developmental processGO:00510941430.011
Mouse Rat
r3 r4 cell differentiationGO:0048056120.011
erbb signaling pathwayGO:0038127580.011
oocyte microtubule cytoskeleton organizationGO:0016325350.011
phagocytosisGO:00069092150.011
regulation of intracellular transportGO:0032386640.011
regulation of hemocyte proliferationGO:0035206370.011
neurological system processGO:00508773580.011
purine nucleotide metabolic processGO:00061631460.011
establishment of spindle orientationGO:0051294180.011
positive regulation of cell communicationGO:00106472500.010
Mouse Rat
maintenance of locationGO:0051235730.010
regulation of anatomical structure sizeGO:00900661630.010
positive regulation of cellular biosynthetic processGO:00313283160.010
regulation of proteolysis involved in cellular protein catabolic processGO:1903050440.010
regulation of meiosisGO:004002030.010
response to organic substanceGO:00100332840.010
Human Rat
oxidation reduction processGO:00551141230.010
regulation of anatomical structure morphogenesisGO:00226032420.010
torc1 signalingGO:0038202120.010
negative regulation of mapk cascadeGO:0043409230.010
r3 r4 cell fate commitmentGO:0007464100.010
epithelial cell migration open tracheal systemGO:0007427320.010
regulation of cell cycle processGO:00105641810.010
germline stem cell asymmetric divisionGO:0098728150.010

R disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.038
musculoskeletal system diseaseDOID:1700.021
connective tissue diseaseDOID:6500.013