IMP: Integrative Multi-species Prediction

Drosophila melanogaster

16 known processes

Socs16D (Dmel_CG8146)

Suppressor of Cytokine Signaling at 16D

(Aliases: socs16D,CG8146,Socs 16D,SOCS,dmSocs16D,Dmel\CG8146,SOCS16D,Socs16E)

FLYBASE: FBgn0030869
Entrez: 32760
UniProtKB: Q9VX18
UniProtKB: M9PHY7

Process Predictions
Disease Predictions

Socs16D biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
learning or memory	GO:0007611	141	0.104	Fly
single organism behavior	GO:0044708	391	0.092	Fly
positive regulation of cell communication	GO:0010647	250	0.078	Fly
locomotory behavior	GO:0007626	176	0.070
cellular catabolic process	GO:0044248	372	0.069
memory	GO:0007613	94	0.064	Fly
regulation of phosphate metabolic process	GO:0019220	210	0.064
organic substance catabolic process	GO:1901575	308	0.063
regulation of phosphorus metabolic process	GO:0051174	210	0.063
phosphorylation	GO:0016310	294	0.063
adult behavior	GO:0030534	137	0.061
lateral inhibition	GO:0046331	206	0.054
organonitrogen compound metabolic process	GO:1901564	318	0.053
protein modification process	GO:0036211	438	0.053	Mouse
positive regulation of signaling	GO:0023056	243	0.051	Fly
organelle fission	GO:0048285	340	0.047
positive regulation of response to stimulus	GO:0048584	323	0.046	Fly
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.046
small molecule metabolic process	GO:0044281	305	0.046
defense response	GO:0006952	300	0.046
macromolecular complex assembly	GO:0065003	256	0.046
wing disc morphogenesis	GO:0007472	344	0.045	Fly
cellular macromolecule catabolic process	GO:0044265	136	0.044
catabolic process	GO:0009056	409	0.044
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.043	Fly
positive regulation of macromolecule metabolic process	GO:0010604	405	0.043
regulation of cellular catabolic process	GO:0031329	157	0.043
regulation of molecular function	GO:0065009	217	0.042
cognition	GO:0050890	141	0.041	Fly
transmembrane transport	GO:0055085	139	0.041
localization of cell	GO:0051674	257	0.040	Mouse Fly
organic acid metabolic process	GO:0006082	103	0.039
organic substance transport	GO:0071702	257	0.039
taxis	GO:0042330	304	0.039
regulation of cellular component biogenesis	GO:0044087	201	0.038
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.038
establishment of localization in cell	GO:0051649	402	0.038
imaginal disc derived appendage development	GO:0048737	399	0.037	Fly
sensory organ morphogenesis	GO:0090596	260	0.037	Fly
compound eye morphogenesis	GO:0001745	249	0.037	Fly
meiotic nuclear division	GO:0007126	151	0.036
eye development	GO:0001654	323	0.036	Fly
regulation of catalytic activity	GO:0050790	185	0.036
compound eye development	GO:0048749	307	0.035	Fly
protein complex biogenesis	GO:0070271	201	0.035
ras protein signal transduction	GO:0007265	88	0.035
regulation of catabolic process	GO:0009894	170	0.035
macromolecule catabolic process	GO:0009057	161	0.034
histone modification	GO:0016570	106	0.034
protein complex assembly	GO:0006461	200	0.034
open tracheal system development	GO:0007424	204	0.033
negative regulation of cellular metabolic process	GO:0031324	382	0.033
chromatin organization	GO:0006325	207	0.033
appendage morphogenesis	GO:0035107	397	0.033	Fly
oxoacid metabolic process	GO:0043436	103	0.033
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.032
cellular protein modification process	GO:0006464	438	0.032	Mouse
chromosome organization	GO:0051276	360	0.032
actin filament based process	GO:0030029	220	0.031
post embryonic appendage morphogenesis	GO:0035120	385	0.031	Fly
spindle organization	GO:0007051	253	0.031
regulation of transport	GO:0051049	181	0.031
nuclear division	GO:0000280	332	0.031
microtubule based movement	GO:0007018	51	0.030
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.030
cellular macromolecular complex assembly	GO:0034622	153	0.029
positive regulation of phosphorus metabolic process	GO:0010562	139	0.029
actin cytoskeleton organization	GO:0030036	206	0.029
synaptic transmission	GO:0007268	288	0.029
regulation of organelle organization	GO:0033043	196	0.028
positive regulation of catalytic activity	GO:0043085	118	0.028
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.028
ion transmembrane transport	GO:0034220	122	0.028
heterocycle catabolic process	GO:0046700	166	0.027
response to monosaccharide	GO:0034284	4	0.027
positive regulation of transport	GO:0051050	92	0.027
positive regulation of rna metabolic process	GO:0051254	271	0.026
positive regulation of molecular function	GO:0044093	136	0.026
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.026	Mouse Fly
negative regulation of gene expression	GO:0010629	387	0.026
positive regulation of signal transduction	GO:0009967	223	0.026	Fly
photoreceptor cell differentiation	GO:0046530	170	0.026	Fly
single organism catabolic process	GO:0044712	228	0.026
positive regulation of biosynthetic process	GO:0009891	316	0.026
nucleoside phosphate metabolic process	GO:0006753	162	0.025
regulation of localization	GO:0032879	275	0.025
eye morphogenesis	GO:0048592	260	0.025	Fly
proteolysis	GO:0006508	192	0.025
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.025
cell motility	GO:0048870	251	0.025	Mouse Fly
intracellular transport	GO:0046907	228	0.025
purine ribonucleoside catabolic process	GO:0046130	112	0.025
immune response	GO:0006955	246	0.025
learning	GO:0007612	75	0.025
multi organism behavior	GO:0051705	175	0.025
positive regulation of cellular biosynthetic process	GO:0031328	316	0.024
regulation of neurogenesis	GO:0050767	158	0.024	Fly
endocytosis	GO:0006897	310	0.024
regulation of phosphorylation	GO:0042325	147	0.024
anion homeostasis	GO:0055081	3	0.024
negative regulation of protein metabolic process	GO:0051248	85	0.024
ribonucleotide catabolic process	GO:0009261	109	0.024
long term memory	GO:0007616	62	0.024	Fly
cell adhesion	GO:0007155	136	0.023
regulation of cytoskeleton organization	GO:0051493	89	0.023
negative regulation of signaling	GO:0023057	219	0.023	Fly
purine containing compound metabolic process	GO:0072521	155	0.023
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.023
cell proliferation	GO:0008283	299	0.023
regulation of hydrolase activity	GO:0051336	97	0.023
chromatin modification	GO:0016568	147	0.023
programmed cell death	GO:0012501	257	0.023
nucleobase containing small molecule metabolic process	GO:0055086	174	0.023
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.022
aromatic compound catabolic process	GO:0019439	166	0.022
neurological system process	GO:0050877	358	0.022	Fly
vesicle mediated transport	GO:0016192	381	0.022
regulation of nucleoside metabolic process	GO:0009118	50	0.022
chemotaxis	GO:0006935	249	0.022
ribonucleoside catabolic process	GO:0042454	112	0.022
small gtpase mediated signal transduction	GO:0007264	88	0.022
cellular response to dna damage stimulus	GO:0006974	223	0.022
regulation of epidermal growth factor receptor signaling pathway	GO:0042058	42	0.022	Fly
carbohydrate derivative metabolic process	GO:1901135	217	0.022
regulation of cellular protein metabolic process	GO:0032268	243	0.022
chemosensory behavior	GO:0007635	106	0.022
purine containing compound catabolic process	GO:0072523	112	0.022
regulation of notch signaling pathway	GO:0008593	100	0.021
organophosphate metabolic process	GO:0019637	195	0.021
homeostatic process	GO:0042592	199	0.021
positive regulation of catabolic process	GO:0009896	105	0.021
response to other organism	GO:0051707	293	0.021
purine ribonucleotide catabolic process	GO:0009154	109	0.021
positive regulation of phosphate metabolic process	GO:0045937	139	0.021
regulation of nervous system development	GO:0051960	248	0.021	Fly
amine metabolic process	GO:0009308	12	0.021
response to nutrient levels	GO:0031667	114	0.021
regulation of anatomical structure morphogenesis	GO:0022603	242	0.021	Fly
regulation of behavior	GO:0050795	75	0.021
purine nucleotide metabolic process	GO:0006163	146	0.021
response to abiotic stimulus	GO:0009628	341	0.021
ion transport	GO:0006811	145	0.021
response to hexose	GO:0009746	3	0.020
body morphogenesis	GO:0010171	2	0.020
regulation of protein metabolic process	GO:0051246	256	0.020
ribose phosphate metabolic process	GO:0019693	145	0.020
cation transport	GO:0006812	110	0.020
positive regulation of purine nucleotide metabolic process	GO:1900544	55	0.020
covalent chromatin modification	GO:0016569	106	0.020
negative regulation of cellular protein metabolic process	GO:0032269	85	0.020
positive regulation of rna biosynthetic process	GO:1902680	266	0.020
cellular amine metabolic process	GO:0044106	12	0.020
ribonucleoside metabolic process	GO:0009119	127	0.019
microtubule based transport	GO:0010970	42	0.019
cellular macromolecule localization	GO:0070727	220	0.019
regulation of cellular amine metabolic process	GO:0033238	3	0.019
imaginal disc derived wing morphogenesis	GO:0007476	337	0.019	Fly
regulation of cell projection organization	GO:0031344	92	0.019
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.019
regulation of ras protein signal transduction	GO:0046578	93	0.019
telencephalon development	GO:0021537	2	0.019	Mouse
male gamete generation	GO:0048232	201	0.019
negative regulation of cell communication	GO:0010648	223	0.019	Fly
carboxylic acid metabolic process	GO:0019752	92	0.019
purine ribonucleoside metabolic process	GO:0046128	127	0.019
regulation of mapk cascade	GO:0043408	92	0.019
meiotic cell cycle	GO:0051321	171	0.019
regionalization	GO:0003002	416	0.018
negative regulation of response to stimulus	GO:0048585	258	0.018	Fly
positive regulation of cellular catabolic process	GO:0031331	95	0.018
gtp metabolic process	GO:0046039	72	0.018
organic cyclic compound catabolic process	GO:1901361	168	0.018
purine nucleotide catabolic process	GO:0006195	109	0.018
cell division	GO:0051301	248	0.018
regulation of nucleotide catabolic process	GO:0030811	48	0.018
purine ribonucleotide metabolic process	GO:0009150	145	0.017
regulation of cellular ketone metabolic process	GO:0010565	3	0.017
regulation of synaptic transmission	GO:0050804	69	0.017
negative regulation of cellular component organization	GO:0051129	108	0.017
biological adhesion	GO:0022610	138	0.017
endomembrane system organization	GO:0010256	119	0.017
regulation of intracellular signal transduction	GO:1902531	236	0.017	Fly
ribonucleotide metabolic process	GO:0009259	145	0.017
appendage development	GO:0048736	401	0.017	Fly
pigmentation	GO:0043473	75	0.017	Fly
regulation of cellular amino acid metabolic process	GO:0006521	0	0.017
protein phosphorylation	GO:0006468	169	0.017
anterior posterior pattern specification	GO:0009952	136	0.017
regulation of membrane potential	GO:0042391	35	0.017
columnar cuboidal epithelial cell development	GO:0002066	249	0.016	Fly
membrane depolarization	GO:0051899	4	0.016
regulation of cellular localization	GO:0060341	136	0.016
chromosome segregation	GO:0007059	157	0.016
positive regulation of developmental process	GO:0051094	143	0.016
dendrite development	GO:0016358	204	0.016
actin filament organization	GO:0007015	126	0.016
cytoskeleton dependent intracellular transport	GO:0030705	44	0.016
regulation of growth	GO:0040008	233	0.016
developmental pigmentation	GO:0048066	68	0.016	Fly
regulation of neuron differentiation	GO:0045664	103	0.016	Fly
protein localization	GO:0008104	284	0.016
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.016
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.016
regulation of purine nucleotide catabolic process	GO:0033121	48	0.016
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.016
nucleus localization	GO:0051647	34	0.016
purine nucleoside metabolic process	GO:0042278	127	0.015
myotube cell development	GO:0014904	3	0.015
nucleotide metabolic process	GO:0009117	161	0.015
organonitrogen compound catabolic process	GO:1901565	128	0.015
chemical homeostasis	GO:0048878	92	0.015
nucleobase containing compound catabolic process	GO:0034655	165	0.015
male meiosis	GO:0007140	52	0.015
forebrain development	GO:0030900	2	0.015	Mouse
positive regulation of intracellular signal transduction	GO:1902533	116	0.015
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.015
intracellular signal transduction	GO:0035556	300	0.015
signal transduction by phosphorylation	GO:0023014	107	0.015
response to glucose	GO:0009749	2	0.015
peptide metabolic process	GO:0006518	80	0.015
aggressive behavior	GO:0002118	63	0.015
nucleotide catabolic process	GO:0009166	109	0.015
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.015
developmental maturation	GO:0021700	172	0.015
triglyceride biosynthetic process	GO:0019432	2	0.015
secretion	GO:0046903	109	0.015
dendrite morphogenesis	GO:0048813	199	0.015
regulation of cell morphogenesis	GO:0022604	163	0.015
regulation of cell substrate adhesion	GO:0010810	2	0.015
cellular homeostasis	GO:0019725	80	0.015
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.015	Mouse Fly
notch signaling pathway	GO:0007219	120	0.015
anterior posterior axis specification	GO:0009948	109	0.015
establishment of organelle localization	GO:0051656	122	0.014
regulation of epithelial cell proliferation	GO:0050678	4	0.014
glycosyl compound metabolic process	GO:1901657	127	0.014
regulation of purine nucleotide metabolic process	GO:1900542	62	0.014
rna localization	GO:0006403	115	0.014
positive regulation of cellular component organization	GO:0051130	156	0.014
protein modification by small protein conjugation or removal	GO:0070647	106	0.014	Mouse
response to wounding	GO:0009611	94	0.014
head development	GO:0060322	135	0.014	Mouse
erbb signaling pathway	GO:0038127	58	0.014	Fly
regulation of multi organism process	GO:0043900	131	0.014
negative regulation of phosphate metabolic process	GO:0045936	45	0.014
regulation of developmental growth	GO:0048638	174	0.014
nucleoside phosphate catabolic process	GO:1901292	110	0.014
compound eye photoreceptor cell differentiation	GO:0001751	140	0.014	Fly
cytoplasmic transport	GO:0016482	130	0.014
cellular ketone metabolic process	GO:0042180	24	0.014
germarium derived egg chamber formation	GO:0007293	101	0.014
negative regulation of molecular function	GO:0044092	51	0.014
apoptotic process	GO:0006915	159	0.014
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.014
negative regulation of signal transduction	GO:0009968	206	0.014	Fly
positive regulation of phosphorylation	GO:0042327	87	0.014
positive regulation of nucleotide catabolic process	GO:0030813	46	0.014
glycosyl compound catabolic process	GO:1901658	112	0.014
mapk cascade	GO:0000165	107	0.013
anterior posterior axis specification embryo	GO:0008595	103	0.013
regulation of protein modification process	GO:0031399	112	0.013
morphogenesis of an epithelium	GO:0002009	276	0.013
eye photoreceptor cell differentiation	GO:0001754	145	0.013	Fly
regulation of synapse structure and activity	GO:0050803	128	0.013
rhythmic process	GO:0048511	106	0.013
olfactory behavior	GO:0042048	97	0.013
peptidyl threonine phosphorylation	GO:0018107	2	0.013
axis specification	GO:0009798	167	0.013
vesicle organization	GO:0016050	44	0.013
golgi vesicle transport	GO:0048193	27	0.013
death	GO:0016265	284	0.013
positive regulation of gene expression	GO:0010628	290	0.013
cellular amino acid metabolic process	GO:0006520	61	0.013
regulation of gtpase activity	GO:0043087	44	0.013
establishment or maintenance of cell polarity	GO:0007163	167	0.013
eye photoreceptor cell development	GO:0042462	81	0.013
positive regulation of cell migration	GO:0030335	2	0.013
compound eye photoreceptor development	GO:0042051	78	0.013
single organism intracellular transport	GO:1902582	207	0.012
skeletal muscle fiber development	GO:0048741	3	0.012
regulation of multicellular organismal development	GO:2000026	414	0.012	Fly
negative regulation of catalytic activity	GO:0043086	42	0.012
hindbrain development	GO:0030902	2	0.012	Mouse
single organism cellular localization	GO:1902580	180	0.012
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.012	Fly
positive regulation of multicellular organismal process	GO:0051240	143	0.012
ion homeostasis	GO:0050801	55	0.012
positive regulation of mapk cascade	GO:0043410	63	0.012
response to external biotic stimulus	GO:0043207	293	0.012
peptidyl amino acid modification	GO:0018193	105	0.012
maintenance of location	GO:0051235	73	0.012
rho protein signal transduction	GO:0007266	14	0.012
response to nitrogen compound	GO:1901698	90	0.012	Mouse
modification dependent macromolecule catabolic process	GO:0043632	79	0.012
regulation of gtp catabolic process	GO:0033124	44	0.012
positive regulation of ion transmembrane transporter activity	GO:0032414	4	0.012
developmental growth	GO:0048589	280	0.012
circadian behavior	GO:0048512	76	0.012
response to extracellular stimulus	GO:0009991	116	0.012
nucleoside triphosphate metabolic process	GO:0009141	120	0.012
neuron projection guidance	GO:0097485	241	0.012
cell death	GO:0008219	279	0.012
regulation of anatomical structure size	GO:0090066	163	0.012
blastoderm segmentation	GO:0007350	159	0.012
kidney epithelium development	GO:0072073	3	0.012
cellular cation homeostasis	GO:0030003	38	0.012
kidney development	GO:0001822	3	0.012
connective tissue development	GO:0061448	3	0.012
cellular nitrogen compound catabolic process	GO:0044270	165	0.011
tissue morphogenesis	GO:0048729	297	0.011
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.011	Fly
positive regulation of nucleotide metabolic process	GO:0045981	55	0.011
organelle localization	GO:0051640	148	0.011
response to lipopolysaccharide	GO:0032496	4	0.011
guanosine containing compound catabolic process	GO:1901069	74	0.011
single organism membrane organization	GO:0044802	93	0.011
mitotic cytokinesis	GO:0000281	50	0.011
dna metabolic process	GO:0006259	227	0.011
camera type eye development	GO:0043010	4	0.011
regulation of erbb signaling pathway	GO:1901184	42	0.011	Fly
positive regulation of purine nucleotide catabolic process	GO:0033123	46	0.011
positive regulation of gtpase activity	GO:0043547	43	0.011
regulation of cellular component movement	GO:0051270	42	0.011
protein catabolic process	GO:0030163	101	0.011
cation homeostasis	GO:0055080	51	0.011
negative regulation of rna metabolic process	GO:0051253	251	0.011
adult locomotory behavior	GO:0008344	76	0.011
cellular response to hexose stimulus	GO:0071331	1	0.011
defense response to bacterium	GO:0042742	178	0.011
salivary gland development	GO:0007431	162	0.011
cellular protein localization	GO:0034613	160	0.011
cytoplasm organization	GO:0007028	64	0.011
gtp catabolic process	GO:0006184	72	0.011
regulation of organ morphogenesis	GO:2000027	78	0.011	Fly
negative regulation of cell cycle process	GO:0010948	109	0.011
cell migration	GO:0016477	238	0.011	Mouse Fly
regulation of embryonic development	GO:0045995	68	0.011
brain development	GO:0007420	120	0.011	Mouse
instar larval development	GO:0002168	55	0.011
nitrogen compound transport	GO:0071705	85	0.011
polyol biosynthetic process	GO:0046173	3	0.011
detection of stimulus involved in sensory perception	GO:0050906	92	0.011
axonogenesis	GO:0007409	290	0.011
mesenchymal cell development	GO:0014031	1	0.011
regulation of synapse organization	GO:0050807	110	0.011
embryonic pattern specification	GO:0009880	174	0.011
guanosine containing compound metabolic process	GO:1901068	74	0.011
epithelial cell migration	GO:0010631	148	0.011	Fly
establishment of nucleus localization	GO:0040023	26	0.011
nucleoside metabolic process	GO:0009116	127	0.011
negative regulation of epithelial cell proliferation	GO:0050680	4	0.011
detection of stimulus	GO:0051606	156	0.010
cytokinesis	GO:0000910	90	0.010
response to copper ion	GO:0046688	4	0.010
tube morphogenesis	GO:0035239	191	0.010
regulation of gene expression epigenetic	GO:0040029	128	0.010
nucleoside catabolic process	GO:0009164	112	0.010
eye pigmentation	GO:0048069	43	0.010	Fly
carbohydrate derivative catabolic process	GO:1901136	118	0.010
translation	GO:0006412	69	0.010
associative learning	GO:0008306	65	0.010
negative regulation of multicellular organismal process	GO:0051241	142	0.010	Fly
stem cell differentiation	GO:0048863	117	0.010	Fly
aging	GO:0007568	143	0.010
growth	GO:0040007	359	0.010
chitin based cuticle development	GO:0040003	49	0.010
epithelium migration	GO:0090132	148	0.010	Fly
humoral immune response	GO:0006959	117	0.010
detection of abiotic stimulus	GO:0009582	66	0.010
ovarian follicle cell development	GO:0030707	248	0.010	Fly
circadian rhythm	GO:0007623	105	0.010
establishment of synaptic vesicle localization	GO:0097480	50	0.010
germarium derived oocyte differentiation	GO:0030706	29	0.010
amide biosynthetic process	GO:0043604	42	0.010
positive regulation of organelle organization	GO:0010638	65	0.010

Socs16D disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.048
cardiovascular system disease	DOID:1287	0.027
nervous system disease	DOID:863	0.021
vascular disease	DOID:178	0.019
disease of cellular proliferation	DOID:14566	0.018
cancer	DOID:162	0.018
artery disease	DOID:0050828	0.014
organ system cancer	DOID:0050686	0.011
carbohydrate metabolism disease	DOID:0050013	0.010
diabetes mellitus	DOID:9351	0.010
disease of metabolism	DOID:0014667	0.010
acquired metabolic disease	DOID:0060158	0.010
glucose metabolism disease	DOID:4194	0.010

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