IMP: Integrative Multi-species Prediction

Drosophila melanogaster

217 known processes

th (Dmel_CG12284)

thread

(Aliases: Diap-1/Th,l(3)72Dc,D-iap1,l(3)S106503,diap1,E(rpr)3-1,Diap,DIAPI,dIap1,DIAP I,IAP1,Diap-1,dIAP1,DIAP-1,CG12284,0736/01,l(3)72CDe,l(3)S030605b,diap 1,dIAP-1,DIAP1,IAP,dIAP,Dmel\CG12284,l(3)j5C8,1065/03,diap-1,Iap1,D-IAP1,diap1/thread,l(3)S030605,diap,Diap2,Diap1,S048915,DIAP)

Entrez: 39753
FLYBASE: FBgn0260635
UniProtKB: M9PI74
UniProtKB: Q24306

Process Predictions
Disease Predictions

th biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
regulation of cysteine type endopeptidase activity	GO:2000116	27	0.992
regulation of endopeptidase activity	GO:0052548	36	0.982
positive regulation of cysteine type endopeptidase activity	GO:2001056	24	0.964
positive regulation of endopeptidase activity	GO:0010950	26	0.961
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	23	0.957
regulation of peptidase activity	GO:0052547	39	0.953
positive regulation of peptidase activity	GO:0010952	29	0.923
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	25	0.912
positive regulation of proteolysis	GO:0045862	52	0.864
execution phase of apoptosis	GO:0097194	7	0.831
activation of cysteine type endopeptidase activity	GO:0097202	17	0.758
spermatid differentiation	GO:0048515	114	0.743
positive regulation of compound eye retinal cell programmed cell death	GO:0046672	9	0.721
regulation of compound eye retinal cell programmed cell death	GO:0046669	18	0.716
developmental programmed cell death	GO:0010623	138	0.690
apoptotic signaling pathway	GO:0097190	27	0.688
activation of cysteine type endopeptidase activity involved in apoptotic process	GO:0006919	16	0.655
protein maturation	GO:0051604	71	0.652
regulation of protein metabolic process	GO:0051246	256	0.650
proteolysis	GO:0006508	192	0.648
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.581
regulation of apoptotic process	GO:0042981	130	0.576
positive regulation of macroautophagy	GO:0016239	8	0.573
positive regulation of retinal cell programmed cell death	GO:0046670	9	0.563
regulation of cell death	GO:0010941	173	0.524
establishment of localization in cell	GO:0051649	402	0.522
programmed cell death	GO:0012501	257	0.508
zymogen activation	GO:0031638	20	0.508
intrinsic apoptotic signaling pathway	GO:0097193	16	0.489
regulation of proteolysis	GO:0030162	87	0.466
cellular catabolic process	GO:0044248	372	0.457
tissue death	GO:0016271	102	0.447
cell death	GO:0008219	279	0.445
regulation of apoptotic signaling pathway	GO:2001233	10	0.439
defense response	GO:0006952	300	0.432
macroautophagy	GO:0016236	42	0.404
negative regulation of gene expression	GO:0010629	387	0.404
regulation of cellular catabolic process	GO:0031329	157	0.394
regulation of molecular function	GO:0065009	217	0.374
cellular response to extracellular stimulus	GO:0031668	64	0.373
gland morphogenesis	GO:0022612	145	0.369
negative regulation of programmed cell death	GO:0043069	72	0.353
cellularization	GO:0007349	90	0.349
response to ionizing radiation	GO:0010212	32	0.338
single organism catabolic process	GO:0044712	228	0.335
regulation of multi organism process	GO:0043900	131	0.330
regulation of programmed cell death	GO:0043067	152	0.324
ectopic germ cell programmed cell death	GO:0035234	8	0.318
regulation of response to extracellular stimulus	GO:0032104	18	0.315
peptide metabolic process	GO:0006518	80	0.311
dendrite development	GO:0016358	204	0.310
positive regulation of cellular protein metabolic process	GO:0032270	118	0.308
regulation of catabolic process	GO:0009894	170	0.308
humoral immune response	GO:0006959	117	0.308
positive regulation of response to nutrient levels	GO:0032109	8	0.306
spermatid development	GO:0007286	98	0.305
regulation of hydrolase activity	GO:0051336	97	0.298
cellular response to starvation	GO:0009267	61	0.298
peptidoglycan recognition protein signaling pathway	GO:0061057	16	0.291
protein transport	GO:0015031	155	0.290
negative regulation of signaling	GO:0023057	219	0.281
response to abiotic stimulus	GO:0009628	341	0.280
positive regulation of programmed cell death	GO:0043068	62	0.277
positive regulation of macromolecule metabolic process	GO:0010604	405	0.276
single organism intracellular transport	GO:1902582	207	0.275
spermatogenesis	GO:0007283	200	0.271
intrinsic apoptotic signaling pathway in response to dna damage	GO:0008630	11	0.271
retinal cell programmed cell death	GO:0046666	25	0.270
cellular macromolecule catabolic process	GO:0044265	136	0.264
salivary gland cell autophagic cell death	GO:0035071	83	0.262
melanin metabolic process	GO:0006582	47	0.261
regulation of defense response	GO:0031347	102	0.258
pigment metabolic process	GO:0042440	84	0.257
histolysis	GO:0007559	102	0.256
positive regulation of cell death	GO:0010942	69	0.253
apoptotic process	GO:0006915	159	0.248
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.237
macromolecular complex assembly	GO:0065003	256	0.231
regulation of catalytic activity	GO:0050790	185	0.231
regulation of response to nutrient levels	GO:0032107	18	0.229
exocrine system development	GO:0035272	162	0.226
protein catabolic process	GO:0030163	101	0.225
male gamete generation	GO:0048232	201	0.219
response to radiation	GO:0009314	155	0.215
response to external biotic stimulus	GO:0043207	293	0.211
salivary gland morphogenesis	GO:0007435	145	0.211
protein processing	GO:0016485	68	0.210
autophagy	GO:0006914	108	0.207
death	GO:0016265	284	0.206
compound eye retinal cell programmed cell death	GO:0046667	23	0.205
regulation of cellular protein metabolic process	GO:0032268	243	0.203
cellular response to nutrient levels	GO:0031669	62	0.202
positive regulation of autophagy	GO:0010508	21	0.200
response to starvation	GO:0042594	97	0.199
sperm individualization	GO:0007291	48	0.198
positive regulation of rna metabolic process	GO:0051254	271	0.197
determination of adult lifespan	GO:0008340	137	0.196
eye development	GO:0001654	323	0.191
positive regulation of response to extracellular stimulus	GO:0032106	8	0.190
negative regulation of cell communication	GO:0010648	223	0.187
catabolic process	GO:0009056	409	0.187
positive regulation of hydrolase activity	GO:0051345	78	0.185
defense response to virus	GO:0051607	23	0.184
autophagic cell death	GO:0048102	83	0.183
regulation of macroautophagy	GO:0016241	15	0.182
negative regulation of cell cycle process	GO:0010948	109	0.180
salivary gland development	GO:0007431	162	0.179
negative regulation of apoptotic process	GO:0043066	63	0.179
immune response	GO:0006955	246	0.177
positive regulation of biosynthetic process	GO:0009891	316	0.176
regulation of organ morphogenesis	GO:2000027	78	0.174
cell type specific apoptotic process	GO:0097285	38	0.174
response to biotic stimulus	GO:0009607	294	0.173
cellular response to external stimulus	GO:0071496	66	0.170
homeostatic process	GO:0042592	199	0.168
eye morphogenesis	GO:0048592	260	0.168
protein k48 linked ubiquitination	GO:0070936	3	0.163
macromolecule catabolic process	GO:0009057	161	0.159
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.157
regulation of humoral immune response	GO:0002920	51	0.155
response to extracellular stimulus	GO:0009991	116	0.153
antimicrobial humoral response	GO:0019730	99	0.152
immune system process	GO:0002376	347	0.151
antimicrobial peptide production	GO:0002775	46	0.142
cellular response to abiotic stimulus	GO:0071214	58	0.141
regulation of cell differentiation	GO:0045595	302	0.139
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.138
melanization defense response	GO:0035006	45	0.136
response to bacterium	GO:0009617	198	0.136
regulation of anatomical structure morphogenesis	GO:0022603	242	0.134
defense response to bacterium	GO:0042742	178	0.134
multicellular organismal aging	GO:0010259	140	0.133
negative regulation of cell cycle phase transition	GO:1901988	103	0.131
positive regulation of cellular biosynthetic process	GO:0031328	316	0.131
defense response to other organism	GO:0098542	225	0.123
organonitrogen compound metabolic process	GO:1901564	318	0.123
cellular amide metabolic process	GO:0043603	80	0.122
salivary gland histolysis	GO:0035070	88	0.121
regulation of cell cycle	GO:0051726	291	0.120
organic substance catabolic process	GO:1901575	308	0.120
negative regulation of cellular protein metabolic process	GO:0032269	85	0.119
dendrite morphogenesis	GO:0048813	199	0.119
positive regulation of protein metabolic process	GO:0051247	128	0.119
protein localization	GO:0008104	284	0.117
positive regulation of developmental process	GO:0051094	143	0.117
regulation of immune effector process	GO:0002697	52	0.117
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.116
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.115
positive regulation of gene expression	GO:0010628	290	0.115
regulation of response to stress	GO:0080134	200	0.113
positive regulation of transcription dna templated	GO:0045893	266	0.112
synaptic transmission	GO:0007268	288	0.112
response to other organism	GO:0051707	293	0.112
regulation of cell cycle phase transition	GO:1901987	130	0.109
intracellular signal transduction	GO:0035556	300	0.108
regulation of execution phase of apoptosis	GO:1900117	5	0.108
protein complex assembly	GO:0006461	200	0.104
nurse cell apoptotic process	GO:0045476	17	0.104
positive regulation of apoptotic process	GO:0043065	47	0.103
mitotic cell cycle checkpoint	GO:0007093	88	0.100
regulation of autophagy	GO:0010506	62	0.099
regulation of response to external stimulus	GO:0032101	115	0.097
vesicle mediated transport	GO:0016192	381	0.096
protein heterooligomerization	GO:0051291	4	0.095
apoptotic process involved in development	GO:1902742	20	0.093
chemical homeostasis	GO:0048878	92	0.091
appendage morphogenesis	GO:0035107	397	0.091
negative regulation of cell death	GO:0060548	81	0.091
endocytosis	GO:0006897	310	0.088
secondary metabolic process	GO:0019748	75	0.088
regulation of defense response to bacterium	GO:1900424	30	0.086
protein complex biogenesis	GO:0070271	201	0.085
cellular protein catabolic process	GO:0044257	83	0.085
regulation of mitotic cell cycle	GO:0007346	190	0.084
intracellular transport	GO:0046907	228	0.084
head involution	GO:0008258	35	0.083
nucleobase containing compound catabolic process	GO:0034655	165	0.083
negative regulation of cellular metabolic process	GO:0031324	382	0.080
immune effector process	GO:0002252	98	0.080
positive regulation of transport	GO:0051050	92	0.079
negative regulation of mitotic cell cycle	GO:0045930	109	0.079
phenol containing compound metabolic process	GO:0018958	57	0.079
production of molecular mediator of immune response	GO:0002440	46	0.079
cellular response to dna damage stimulus	GO:0006974	223	0.077
negative regulation of response to stimulus	GO:0048585	258	0.077
regulation of cellular amide metabolic process	GO:0034248	39	0.076
regulation of immune response	GO:0050776	118	0.076
modification dependent macromolecule catabolic process	GO:0043632	79	0.076
establishment of protein localization	GO:0045184	163	0.075
neuromuscular synaptic transmission	GO:0007274	67	0.074
positive regulation of catalytic activity	GO:0043085	118	0.074
nucleobase containing small molecule metabolic process	GO:0055086	174	0.074
cell adhesion	GO:0007155	136	0.073
ubiquitin dependent protein catabolic process	GO:0006511	78	0.072
regulation of production of molecular mediator of immune response	GO:0002700	44	0.072
positive regulation of cell differentiation	GO:0045597	64	0.072
organic substance transport	GO:0071702	257	0.071
cellular response to sterol depletion	GO:0071501	3	0.071
negative regulation of cell cycle	GO:0045786	116	0.071
regulation of defense response to virus	GO:0050688	14	0.070
central nervous system development	GO:0007417	201	0.070
dna metabolic process	GO:0006259	227	0.069
cellular homeostasis	GO:0019725	80	0.069
regulation of synaptic transmission	GO:0050804	69	0.068
regulation of cell cycle process	GO:0010564	181	0.068
positive regulation of rna biosynthetic process	GO:1902680	266	0.066
growth	GO:0040007	359	0.066
compound eye morphogenesis	GO:0001745	249	0.066
cell cycle phase transition	GO:0044770	140	0.064
compound eye development	GO:0048749	307	0.064
sensory organ morphogenesis	GO:0090596	260	0.063
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.063
transcription from rna polymerase ii promoter	GO:0006366	368	0.062
positive regulation of multi organism process	GO:0043902	40	0.062
mitotic cell cycle phase transition	GO:0044772	138	0.061
regulation of cellular response to stress	GO:0080135	89	0.061
embryonic development via the syncytial blastoderm	GO:0001700	148	0.060
extrinsic apoptotic signaling pathway	GO:0097191	1	0.059
chromosome organization	GO:0051276	360	0.059
gland development	GO:0048732	191	0.059
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.058
regulation of immune system process	GO:0002682	176	0.057
regulation of antimicrobial peptide production	GO:0002784	44	0.056
mitotic nuclear division	GO:0007067	213	0.056
heterocycle catabolic process	GO:0046700	166	0.056
intracellular protein transport	GO:0006886	104	0.055
negative regulation of protein processing	GO:0010955	31	0.055
mitotic dna integrity checkpoint	GO:0044774	75	0.055
regulation of protein transport	GO:0051223	57	0.054
nucleocytoplasmic transport	GO:0006913	72	0.054
positive regulation of cell development	GO:0010720	61	0.054
cellular nitrogen compound catabolic process	GO:0044270	165	0.053
negative regulation of proteolysis	GO:0045861	31	0.052
regulation of cell development	GO:0060284	215	0.051
forebrain development	GO:0030900	2	0.048
cell cycle checkpoint	GO:0000075	95	0.048
biological adhesion	GO:0022610	138	0.048
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.047
cytoplasmic transport	GO:0016482	130	0.047
negative regulation of signal transduction	GO:0009968	206	0.047
embryo development ending in birth or egg hatching	GO:0009792	152	0.047
response to nutrient levels	GO:0031667	114	0.046
antibacterial peptide biosynthetic process	GO:0002780	22	0.045
neuron remodeling	GO:0016322	29	0.045
regulation of antimicrobial humoral response	GO:0002759	50	0.045
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.045
regulation of dna metabolic process	GO:0051052	34	0.044
purine nucleoside metabolic process	GO:0042278	127	0.044
regulation of protein localization	GO:0032880	76	0.044
modification dependent protein catabolic process	GO:0019941	78	0.044
regulation of response to wounding	GO:1903034	19	0.043
positive regulation of antibacterial peptide biosynthetic process	GO:0006963	20	0.043
regulation of protein processing	GO:0070613	32	0.043
membrane organization	GO:0061024	112	0.043
positive regulation of multicellular organismal process	GO:0051240	143	0.043
regulation of intracellular signal transduction	GO:1902531	236	0.043
positive regulation of cellular catabolic process	GO:0031331	95	0.043
regulation of multicellular organismal development	GO:2000026	414	0.042
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.041
single organism cellular localization	GO:1902580	180	0.041
positive regulation of signaling	GO:0023056	243	0.040
response to organic substance	GO:0010033	284	0.040
regulation of establishment of protein localization	GO:0070201	61	0.040
positive regulation of response to stimulus	GO:0048584	323	0.040
regulation of retinal cell programmed cell death	GO:0046668	18	0.039
alpha amino acid metabolic process	GO:1901605	20	0.039
microtubule organizing center organization	GO:0031023	168	0.039
negative regulation of endopeptidase activity	GO:0010951	11	0.039
cellular amino acid metabolic process	GO:0006520	61	0.038
regulation of growth	GO:0040008	233	0.038
response to x ray	GO:0010165	8	0.037
developmental maturation	GO:0021700	172	0.037
aromatic compound catabolic process	GO:0019439	166	0.037
positive regulation of protein transport	GO:0051222	37	0.037
positive regulation of cell communication	GO:0010647	250	0.037
cellular macromolecular complex assembly	GO:0034622	153	0.037
protein modification by small protein conjugation	GO:0032446	79	0.036
establishment or maintenance of cell polarity	GO:0007163	167	0.036
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.036
dna conformation change	GO:0071103	105	0.036
hemocyte differentiation	GO:0042386	38	0.035
antibacterial humoral response	GO:0019731	44	0.035
regulation of localization	GO:0032879	275	0.035
negative regulation of protein maturation	GO:1903318	31	0.035
post embryonic appendage morphogenesis	GO:0035120	385	0.035
innate immune response	GO:0045087	144	0.034
organelle fission	GO:0048285	340	0.034
positive regulation of humoral immune response	GO:0002922	28	0.033
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.033
secretion	GO:0046903	109	0.033
regulation of antibacterial peptide production	GO:0002786	22	0.033
cellular protein localization	GO:0034613	160	0.033
response to oxygen levels	GO:0070482	59	0.032
centrosome organization	GO:0051297	163	0.032
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.031
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.031
regulation of cellular localization	GO:0060341	136	0.031
regulation of transport	GO:0051049	181	0.031
anatomical structure homeostasis	GO:0060249	97	0.031
positive regulation of biosynthetic process of antibacterial peptides active against gram negative bacteria	GO:0006964	12	0.031
positive regulation of response to external stimulus	GO:0032103	44	0.031
mitotic dna damage checkpoint	GO:0044773	74	0.031
epithelial cell development	GO:0002064	274	0.031
cellular response to mechanical stimulus	GO:0071260	2	0.030
organic cyclic compound catabolic process	GO:1901361	168	0.030
protein modification by small protein conjugation or removal	GO:0070647	106	0.030
regulation of nervous system development	GO:0051960	248	0.030
regulation of neuromuscular synaptic transmission	GO:1900073	15	0.030
cell maturation	GO:0048469	144	0.030
response to virus	GO:0009615	28	0.029
amide biosynthetic process	GO:0043604	42	0.029
carboxylic acid metabolic process	GO:0019752	92	0.029
protein secretion	GO:0009306	45	0.029
purine containing compound metabolic process	GO:0072521	155	0.028
positive regulation of immune effector process	GO:0002699	28	0.028
defense response to gram negative bacterium	GO:0050829	94	0.028
s adenosylmethionine cycle	GO:0033353	3	0.028
small molecule metabolic process	GO:0044281	305	0.028
glycosyl compound metabolic process	GO:1901657	127	0.027
protein modification process	GO:0036211	438	0.027
centrosome duplication	GO:0051298	121	0.027
oxoacid metabolic process	GO:0043436	103	0.026
phagocytosis	GO:0006909	215	0.026
carbohydrate derivative metabolic process	GO:1901135	217	0.026
nucleoside metabolic process	GO:0009116	127	0.026
purine ribonucleoside metabolic process	GO:0046128	127	0.025
regulation of epidermal growth factor receptor signaling pathway	GO:0042058	42	0.025
organic acid metabolic process	GO:0006082	103	0.025
regulation of vesicle mediated transport	GO:0060627	59	0.025
negative regulation of catalytic activity	GO:0043086	42	0.025
negative regulation of protein metabolic process	GO:0051248	85	0.025
positive regulation of catabolic process	GO:0009896	105	0.025
regulation of cellular component biogenesis	GO:0044087	201	0.024
nuclear transport	GO:0051169	72	0.024
positive regulation of defense response to bacterium	GO:1900426	23	0.024
nuclear division	GO:0000280	332	0.024
regulation of response to biotic stimulus	GO:0002831	63	0.024
negative regulation of catabolic process	GO:0009895	36	0.024
positive regulation of antimicrobial peptide biosynthetic process	GO:0002807	26	0.023
cellular component disassembly	GO:0022411	46	0.023
protein targeting	GO:0006605	64	0.023
cytoskeleton dependent intracellular transport	GO:0030705	44	0.023
positive regulation of signal transduction	GO:0009967	223	0.023
cell cycle arrest	GO:0007050	4	0.023
cellular response to chemical stimulus	GO:0070887	199	0.023
positive regulation of molecular function	GO:0044093	136	0.023
negative regulation of cellular catabolic process	GO:0031330	34	0.023
antibacterial peptide production	GO:0002778	22	0.023
regulation of organelle organization	GO:0033043	196	0.023
cellular macromolecule localization	GO:0070727	220	0.022
nuclear import	GO:0051170	51	0.022
positive regulation of protein secretion	GO:0050714	9	0.022
dna packaging	GO:0006323	91	0.022
ribonucleoside metabolic process	GO:0009119	127	0.022
morphogenesis of embryonic epithelium	GO:0016331	94	0.022
actin filament organization	GO:0007015	126	0.022
mitotic spindle organization	GO:0007052	220	0.022
columnar cuboidal epithelial cell development	GO:0002066	249	0.022
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.022
brain development	GO:0007420	120	0.021
cellular protein modification process	GO:0006464	438	0.021
regulation of synapse organization	GO:0050807	110	0.021
peptide biosynthetic process	GO:0043043	42	0.021
secretion by cell	GO:0032940	101	0.021
regulation of cell shape	GO:0008360	113	0.021
regulation of cell proliferation	GO:0042127	163	0.020
negative regulation of molecular function	GO:0044092	51	0.020
spindle organization	GO:0007051	253	0.020
positive regulation of antimicrobial peptide production	GO:0002225	28	0.020
positive regulation of antibacterial peptide production	GO:0002803	20	0.020
regulation of antibacterial peptide biosynthetic process	GO:0002808	22	0.020
posttranscriptional regulation of gene expression	GO:0010608	145	0.019
mitochondrion organization	GO:0007005	65	0.019
regulation of proteasomal protein catabolic process	GO:0061136	39	0.019
neuron maturation	GO:0042551	31	0.019
protein ubiquitination	GO:0016567	70	0.019
positive regulation of intracellular signal transduction	GO:1902533	116	0.019
regulation of synapse structure and activity	GO:0050803	128	0.019
neuron apoptotic process	GO:0051402	17	0.019
negative regulation of intracellular signal transduction	GO:1902532	57	0.019
translation	GO:0006412	69	0.018
lateral inhibition	GO:0046331	206	0.018
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.018
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.018
nucleoside phosphate metabolic process	GO:0006753	162	0.018
regulation of erbb signaling pathway	GO:1901184	42	0.018
positive regulation of defense response	GO:0031349	59	0.018
regulation of antimicrobial peptide biosynthetic process	GO:0002805	38	0.018
single organism behavior	GO:0044708	391	0.018
membrane depolarization	GO:0051899	4	0.018
negative regulation of synaptic transmission	GO:0050805	12	0.018
regulation of cellular amine metabolic process	GO:0033238	3	0.017
positive regulation of i kappab kinase nf kappab signaling	GO:0043123	1	0.017
locomotory behavior	GO:0007626	176	0.017
neuron death	GO:0070997	27	0.017
regulation of cellular protein catabolic process	GO:1903362	44	0.017
proteasomal protein catabolic process	GO:0010498	59	0.017
negative regulation of organelle organization	GO:0010639	56	0.016
response to gamma radiation	GO:0010332	17	0.016
signal transduction in response to dna damage	GO:0042770	3	0.016
chromosome segregation	GO:0007059	157	0.016
cellular protein complex assembly	GO:0043623	71	0.016
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	GO:0070059	4	0.016
response to organic cyclic compound	GO:0014070	89	0.016
nucleotide metabolic process	GO:0009117	161	0.016
gtp metabolic process	GO:0046039	72	0.015
response to hypoxia	GO:0001666	53	0.015
response to lipid	GO:0033993	38	0.015
regulation of neurogenesis	GO:0050767	158	0.015
response to wounding	GO:0009611	94	0.015
response to alcohol	GO:0097305	95	0.015
imaginal disc derived appendage development	GO:0048737	399	0.015
centrosome cycle	GO:0007098	137	0.015
positive regulation of immune system process	GO:0002684	68	0.015
chromatin assembly or disassembly	GO:0006333	52	0.015
regulation of protein catabolic process	GO:0042176	55	0.015
organic hydroxy compound metabolic process	GO:1901615	83	0.015
response to decreased oxygen levels	GO:0036293	58	0.015
g1 s transition of mitotic cell cycle	GO:0000082	31	0.014
positive regulation of exocytosis	GO:0045921	4	0.014
dna damage checkpoint	GO:0000077	78	0.014
biosynthetic process of antibacterial peptides active against gram negative bacteria	GO:0002812	14	0.014
chromatin organization	GO:0006325	207	0.014
synaptic growth at neuromuscular junction	GO:0051124	119	0.014
endosomal transport	GO:0016197	44	0.014
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.014
regulation of cell cycle g1 s phase transition	GO:1902806	23	0.014
response to lipopolysaccharide	GO:0032496	4	0.014
adult behavior	GO:0030534	137	0.014
positive regulation of production of molecular mediator of immune response	GO:0002702	28	0.014
necrotic cell death	GO:0070265	1	0.014
regulation of intracellular transport	GO:0032386	64	0.014
negative regulation of rna biosynthetic process	GO:1902679	240	0.014
ovarian follicle cell development	GO:0030707	248	0.014
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.014
cytoskeleton dependent cytokinesis	GO:0061640	81	0.014
photoreceptor cell differentiation	GO:0046530	170	0.013
ras protein signal transduction	GO:0007265	88	0.013
antimicrobial peptide biosynthetic process	GO:0002777	38	0.013
regulation of cytoplasmic transport	GO:1903649	47	0.013
response to organophosphorus	GO:0046683	2	0.013
dna integrity checkpoint	GO:0031570	81	0.013
microtubule based transport	GO:0010970	42	0.013
organophosphate metabolic process	GO:0019637	195	0.013
cell migration	GO:0016477	238	0.013
synapse organization	GO:0050808	196	0.013
negative regulation of cellular biosynthetic process	GO:0031327	277	0.013
single organism membrane organization	GO:0044802	93	0.013
sister chromatid segregation	GO:0000819	92	0.012
regulation of phosphate metabolic process	GO:0019220	210	0.012
larval midgut cell programmed cell death	GO:0035096	19	0.012
small gtpase mediated signal transduction	GO:0007264	88	0.012
cell cycle g1 s phase transition	GO:0044843	31	0.012
negative regulation of immune response	GO:0050777	39	0.012
phagocytosis engulfment	GO:0006911	11	0.012
actin filament based process	GO:0030029	220	0.012
protein targeting to nucleus	GO:0044744	51	0.012
ribose phosphate metabolic process	GO:0019693	145	0.012
negative regulation of neuromuscular synaptic transmission	GO:1900074	7	0.012
regulation of intracellular protein transport	GO:0033157	46	0.012
regulation of biosynthetic process of antibacterial peptides active against gram negative bacteria	GO:0002813	14	0.012
regulation of mitosis	GO:0007088	56	0.012
actin cytoskeleton organization	GO:0030036	206	0.012
regulation of chromosome organization	GO:0033044	64	0.012
protein localization to organelle	GO:0033365	82	0.012
multi organism reproductive behavior	GO:0044705	121	0.012
negative regulation of transcription dna templated	GO:0045892	237	0.012
wing disc morphogenesis	GO:0007472	344	0.012
regulation of protein complex assembly	GO:0043254	42	0.011
cell proliferation	GO:0008283	299	0.011
single organism nuclear import	GO:1902593	51	0.011
lipid homeostasis	GO:0055088	33	0.011
developmental pigmentation	GO:0048066	68	0.011
cell motility	GO:0048870	251	0.011
negative regulation of rna metabolic process	GO:0051253	251	0.011
negative regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032435	16	0.011
mitotic sister chromatid segregation	GO:0000070	87	0.011
cytokinesis	GO:0000910	90	0.011
cell division	GO:0051301	248	0.011
sulfur compound metabolic process	GO:0006790	59	0.011
er nucleus signaling pathway	GO:0006984	9	0.011
regulation of nucleocytoplasmic transport	GO:0046822	35	0.011
gtp catabolic process	GO:0006184	72	0.011
regulation of cellular amino acid metabolic process	GO:0006521	0	0.011
organonitrogen compound biosynthetic process	GO:1901566	117	0.011
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.010
negative regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043154	2	0.010
protein import into nucleus	GO:0006606	51	0.010
erbb signaling pathway	GO:0038127	58	0.010
regulation of phosphorus metabolic process	GO:0051174	210	0.010
gonad development	GO:0008406	50	0.010
sex differentiation	GO:0007548	81	0.010

th disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.073
nervous system disease	DOID:863	0.015
neurodegenerative disease	DOID:1289	0.012
central nervous system disease	DOID:331	0.012

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