IMP: Integrative Multi-species Prediction

Drosophila melanogaster

102 known processes

sev (Dmel_CG18085)

sevenless

(Aliases: HD-265,SEV,CT3980,Dmel\CG18085,Sev,DROSEV1,DmHD-265,7LES,7less,DROSEV,sev(AC)[[14]],CG18085)

Entrez: 32039
FLYBASE: FBgn0003366
UniProtKB: P13368

Process Predictions
Disease Predictions

sev biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
compound eye photoreceptor fate commitment	GO:0001752	36	0.995
photoreceptor cell differentiation	GO:0046530	170	0.993
compound eye development	GO:0048749	307	0.983
eye photoreceptor cell differentiation	GO:0001754	145	0.975
compound eye photoreceptor cell differentiation	GO:0001751	140	0.966
r7 cell differentiation	GO:0045466	43	0.953
eye morphogenesis	GO:0048592	260	0.924
compound eye morphogenesis	GO:0001745	249	0.920
photoreceptor cell fate commitment	GO:0046552	41	0.916
eye development	GO:0001654	323	0.912
learning or memory	GO:0007611	141	0.905	Fly
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.859	Fly
taxis	GO:0042330	304	0.845	Fly
neurological system process	GO:0050877	358	0.825	Fly
transcription from rna polymerase ii promoter	GO:0006366	368	0.819
positive regulation of biosynthetic process	GO:0009891	316	0.816
sensory organ morphogenesis	GO:0090596	260	0.805
negative regulation of transcription dna templated	GO:0045892	237	0.787
eye photoreceptor cell fate commitment	GO:0042706	37	0.761
central nervous system development	GO:0007417	201	0.735
tissue migration	GO:0090130	155	0.723
cellular response to light stimulus	GO:0071482	37	0.714
chromatin organization	GO:0006325	207	0.711
regulation of epithelial cell proliferation	GO:0050678	4	0.676
negative regulation of rna biosynthetic process	GO:1902679	240	0.675
learning	GO:0007612	75	0.663	Fly
sensory perception	GO:0007600	196	0.661
imaginal disc derived appendage development	GO:0048737	399	0.648
rhodopsin mediated signaling pathway	GO:0016056	21	0.640
compound eye cone cell fate commitment	GO:0042676	5	0.636
positive regulation of cellular biosynthetic process	GO:0031328	316	0.629
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.627	Fly
brain development	GO:0007420	120	0.622
developmental growth	GO:0048589	280	0.618	Fly
eye photoreceptor cell development	GO:0042462	81	0.615	Fly
respiratory system development	GO:0060541	213	0.606
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.602
compound eye photoreceptor development	GO:0042051	78	0.598	Fly
response to organic substance	GO:0010033	284	0.593	Fly
regulation of neurogenesis	GO:0050767	158	0.579
chemotaxis	GO:0006935	249	0.573	Fly
appendage development	GO:0048736	401	0.530
detection of stimulus	GO:0051606	156	0.528
negative regulation of gene expression	GO:0010629	387	0.526	Mouse
establishment of ommatidial planar polarity	GO:0042067	49	0.518
epithelial cell migration	GO:0010631	148	0.495
chromosome organization	GO:0051276	360	0.494
neuron fate commitment	GO:0048663	50	0.491
positive regulation of cell communication	GO:0010647	250	0.489	Fly
response to abiotic stimulus	GO:0009628	341	0.484	Fly
detection of light stimulus	GO:0009583	58	0.477
synapse organization	GO:0050808	196	0.476
cognition	GO:0050890	141	0.469	Fly
detection of visible light	GO:0009584	38	0.467
cellular response to abiotic stimulus	GO:0071214	58	0.461
regulation of organ morphogenesis	GO:2000027	78	0.450
regulation of multicellular organismal development	GO:2000026	414	0.445
regionalization	GO:0003002	416	0.444
response to radiation	GO:0009314	155	0.436
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.428
positive regulation of response to stimulus	GO:0048584	323	0.424	Fly
head development	GO:0060322	135	0.419
tissue morphogenesis	GO:0048729	297	0.395
intracellular signal transduction	GO:0035556	300	0.390	Human Mouse Fly
negative regulation of multicellular organismal process	GO:0051241	142	0.388	Fly
associative learning	GO:0008306	65	0.386	Fly
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.386
organonitrogen compound metabolic process	GO:1901564	318	0.385
macromolecular complex assembly	GO:0065003	256	0.376
negative regulation of cellular metabolic process	GO:0031324	382	0.376	Fly
negative regulation of rna metabolic process	GO:0051253	251	0.368
erbb signaling pathway	GO:0038127	58	0.367
axonogenesis	GO:0007409	290	0.364	Fly
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.353
carboxylic acid metabolic process	GO:0019752	92	0.346
secretion	GO:0046903	109	0.341
response to light stimulus	GO:0009416	124	0.333
response to other organism	GO:0051707	293	0.332
catabolic process	GO:0009056	409	0.327	Worm Fly
response to oxygen containing compound	GO:1901700	200	0.327	Fly
cellular catabolic process	GO:0044248	372	0.320	Fly
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.312
regulation of cell differentiation	GO:0045595	302	0.312
oxoacid metabolic process	GO:0043436	103	0.311
negative regulation of biosynthetic process	GO:0009890	277	0.308
single organism biosynthetic process	GO:0044711	206	0.305
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.303
cell junction organization	GO:0034330	57	0.302
phototransduction	GO:0007602	52	0.295
organelle fission	GO:0048285	340	0.295
r7 cell development	GO:0045467	14	0.293
regulation of cellular catabolic process	GO:0031329	157	0.291	Fly
localization of cell	GO:0051674	257	0.285
ras protein signal transduction	GO:0007265	88	0.283
morphogenesis of a polarized epithelium	GO:0001738	93	0.280
regulation of nervous system development	GO:0051960	248	0.280
regulation of neuron differentiation	GO:0045664	103	0.279
negative regulation of response to stimulus	GO:0048585	258	0.277	Fly
growth	GO:0040007	359	0.275	Human Fly
epithelium migration	GO:0090132	148	0.271
axon guidance	GO:0007411	233	0.269	Fly
establishment of tissue polarity	GO:0007164	87	0.269
mitotic nuclear division	GO:0007067	213	0.269
response to oxidative stress	GO:0006979	86	0.268	Fly
stem cell differentiation	GO:0048863	117	0.263
r7 cell fate commitment	GO:0007465	12	0.262
mapk cascade	GO:0000165	107	0.262	Mouse Fly
covalent chromatin modification	GO:0016569	106	0.256
morphogenesis of an epithelium	GO:0002009	276	0.255
neuron projection guidance	GO:0097485	241	0.246	Fly
phosphorylation	GO:0016310	294	0.242
negative regulation of nervous system development	GO:0051961	92	0.241
negative regulation of signal transduction	GO:0009968	206	0.240
nuclear division	GO:0000280	332	0.239
immune system process	GO:0002376	347	0.236	Fly
columnar cuboidal epithelial cell development	GO:0002066	249	0.235	Mouse
cellular protein modification process	GO:0006464	438	0.232
immune response	GO:0006955	246	0.226
gliogenesis	GO:0042063	80	0.225
regulation of epithelial cell migration	GO:0010632	12	0.224
neurotransmitter secretion	GO:0007269	35	0.223
regulation of cell development	GO:0060284	215	0.223
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.219
detection of abiotic stimulus	GO:0009582	66	0.217
death	GO:0016265	284	0.216
negative regulation of cell cycle process	GO:0010948	109	0.211
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.210
regulation of anatomical structure morphogenesis	GO:0022603	242	0.207
cellular amino acid metabolic process	GO:0006520	61	0.207
appendage morphogenesis	GO:0035107	397	0.205
negative regulation of neurogenesis	GO:0050768	53	0.203
cell motility	GO:0048870	251	0.200
cellular response to chemical stimulus	GO:0070887	199	0.200	Fly
post embryonic appendage morphogenesis	GO:0035120	385	0.198
g protein coupled receptor signaling pathway	GO:0007186	136	0.198
regulation of phosphorus metabolic process	GO:0051174	210	0.196	Mouse Fly
negative regulation of cell development	GO:0010721	62	0.188
positive regulation of cellular protein metabolic process	GO:0032270	118	0.186	Fly
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.185
positive regulation of photoreceptor cell differentiation	GO:0046534	12	0.185
positive regulation of cell proliferation	GO:0008284	47	0.184	Fly
wing disc morphogenesis	GO:0007472	344	0.184
regulation of response to stress	GO:0080134	200	0.183
cell migration	GO:0016477	238	0.181
regulation of intracellular signal transduction	GO:1902531	236	0.180	Human Mouse Fly
forebrain development	GO:0030900	2	0.180
camera type eye development	GO:0043010	4	0.179
positive regulation of phosphorylation	GO:0042327	87	0.179	Fly
epithelial cell differentiation	GO:0030855	322	0.178	Mouse
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.175	Mouse
photoreceptor cell development	GO:0042461	96	0.174	Fly
organic substance catabolic process	GO:1901575	308	0.174	Worm
cellular response to radiation	GO:0071478	52	0.174
negative regulation of cell communication	GO:0010648	223	0.174	Fly
protein modification process	GO:0036211	438	0.172
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.171
response to monosaccharide	GO:0034284	4	0.170
regulation of reproductive process	GO:2000241	54	0.169
establishment of planar polarity	GO:0001736	87	0.168
dna metabolic process	GO:0006259	227	0.166
developmental maturation	GO:0021700	172	0.166	Fly
embryonic development via the syncytial blastoderm	GO:0001700	148	0.165	Fly
neuroblast proliferation	GO:0007405	74	0.164
tube development	GO:0035295	244	0.160	Fly
regulation of localization	GO:0032879	275	0.158	Mouse
pigmentation	GO:0043473	75	0.156
developmental pigmentation	GO:0048066	68	0.155
response to organic cyclic compound	GO:0014070	89	0.154	Fly
response to biotic stimulus	GO:0009607	294	0.153
protein complex assembly	GO:0006461	200	0.151
organic substance transport	GO:0071702	257	0.151
positive regulation of signaling	GO:0023056	243	0.150	Fly
axon development	GO:0061564	297	0.148	Fly
negative regulation of cell differentiation	GO:0045596	143	0.147
regulation of r7 cell differentiation	GO:0045676	15	0.145
ovarian follicle cell development	GO:0030707	248	0.143
protein localization	GO:0008104	284	0.143
positive regulation of signal transduction	GO:0009967	223	0.143	Fly
regulation of cellular protein metabolic process	GO:0032268	243	0.142	Fly
open tracheal system development	GO:0007424	204	0.142
heart development	GO:0007507	82	0.142
protein complex biogenesis	GO:0070271	201	0.142
chromatin modification	GO:0016568	147	0.140
regulation of protein kinase activity	GO:0045859	51	0.140	Fly
cellular response to oxygen containing compound	GO:1901701	79	0.139	Fly
positive regulation of r7 cell differentiation	GO:0045678	7	0.135
negative regulation of cellular biosynthetic process	GO:0031327	277	0.134
proteolysis	GO:0006508	192	0.134
establishment of localization in cell	GO:0051649	402	0.133
cell cell junction organization	GO:0045216	55	0.131
negative regulation of apoptotic process	GO:0043066	63	0.131
renal tubule morphogenesis	GO:0061333	44	0.131
regulation of cellular response to stress	GO:0080135	89	0.131
cuticle development	GO:0042335	86	0.130	Worm
regulation of membrane potential	GO:0042391	35	0.127
cellular response to nitrogen compound	GO:1901699	51	0.127	Fly
ameboidal type cell migration	GO:0001667	151	0.126
response to external biotic stimulus	GO:0043207	293	0.126
regulation of cellular component movement	GO:0051270	42	0.126
memory	GO:0007613	94	0.126
hindbrain development	GO:0030902	2	0.124
response to hormone	GO:0009725	45	0.123	Fly
eggshell formation	GO:0030703	105	0.121
reproductive structure development	GO:0048608	74	0.120	Fly
dorsal ventral pattern formation	GO:0009953	133	0.120
cardiocyte differentiation	GO:0035051	29	0.118
negative regulation of cell cycle	GO:0045786	116	0.117
positive regulation of macromolecule metabolic process	GO:0010604	405	0.115	Fly
regulation of cellular amino acid metabolic process	GO:0006521	0	0.115
regulation of photoreceptor cell differentiation	GO:0046532	34	0.114
wound healing	GO:0042060	75	0.114
tracheal outgrowth open tracheal system	GO:0007426	18	0.114
organic acid metabolic process	GO:0006082	103	0.114
guanosine containing compound catabolic process	GO:1901069	74	0.113
positive regulation of multicellular organismal process	GO:0051240	143	0.112
small gtpase mediated signal transduction	GO:0007264	88	0.111
regulation of programmed cell death	GO:0043067	152	0.111
centrosome cycle	GO:0007098	137	0.110
response to toxic substance	GO:0009636	22	0.110
epithelial tube morphogenesis	GO:0060562	88	0.108
regulation of immune system process	GO:0002682	176	0.106	Fly
chorion containing eggshell formation	GO:0007304	105	0.105
regulation of phosphorylation	GO:0042325	147	0.104	Mouse Fly
regulation of reactive oxygen species metabolic process	GO:2000377	8	0.104	Fly
deactivation of rhodopsin mediated signaling	GO:0016059	17	0.104
small molecule metabolic process	GO:0044281	305	0.102
erk1 and erk2 cascade	GO:0070371	39	0.099	Mouse Fly
response to alcohol	GO:0097305	95	0.099
phototransduction visible light	GO:0007603	27	0.099
positive regulation of phosphate metabolic process	GO:0045937	139	0.098	Fly
compound eye retinal cell programmed cell death	GO:0046667	23	0.095
regulation of synapse structure and activity	GO:0050803	128	0.095
positive regulation of protein modification process	GO:0031401	58	0.094	Fly
regulation of phosphate metabolic process	GO:0019220	210	0.094	Mouse Fly
oxidation reduction process	GO:0055114	123	0.092
signal release	GO:0023061	49	0.092
positive regulation of transcription dna templated	GO:0045893	266	0.091
response to wounding	GO:0009611	94	0.090
negative regulation of cell death	GO:0060548	81	0.090
positive regulation of gtp catabolic process	GO:0033126	43	0.090
heart process	GO:0003015	37	0.088
compound eye cone cell differentiation	GO:0042675	13	0.088
lipid metabolic process	GO:0006629	121	0.088	Fly
response to reactive oxygen species	GO:0000302	24	0.087
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.087
regulation of mapk cascade	GO:0043408	92	0.087	Mouse Fly
peptidyl amino acid modification	GO:0018193	105	0.087
regulation of molecular function	GO:0065009	217	0.086	Fly
larval development	GO:0002164	104	0.086
digestive system development	GO:0055123	149	0.085	Fly
stem cell development	GO:0048864	79	0.084
digestive tract morphogenesis	GO:0048546	127	0.083
positive regulation of protein metabolic process	GO:0051247	128	0.083	Fly
synapse assembly	GO:0007416	143	0.083
protein transport	GO:0015031	155	0.083
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.082
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.082
visual perception	GO:0007601	9	0.081
apoptotic process	GO:0006915	159	0.080
regulation of response to external stimulus	GO:0032101	115	0.080
adherens junction organization	GO:0034332	27	0.080
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.080
reproductive system development	GO:0061458	74	0.079	Fly
meiotic cell cycle	GO:0051321	171	0.079
epithelial cell migration open tracheal system	GO:0007427	32	0.078
centrosome duplication	GO:0051298	121	0.078
cellular macromolecular complex assembly	GO:0034622	153	0.078
regulation of growth	GO:0040008	233	0.077	Fly
germ cell migration	GO:0008354	43	0.076
amine metabolic process	GO:0009308	12	0.075
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.074
homeostatic process	GO:0042592	199	0.074	Fly
organic hydroxy compound biosynthetic process	GO:1901617	21	0.074
actin cytoskeleton organization	GO:0030036	206	0.073
positive regulation of rna biosynthetic process	GO:1902680	266	0.073
branching morphogenesis of an epithelial tube	GO:0048754	45	0.073
neurotransmitter transport	GO:0006836	37	0.073
regulation of system process	GO:0044057	36	0.073	Fly
axis specification	GO:0009798	167	0.073
kidney development	GO:0001822	3	0.072
positive regulation of molecular function	GO:0044093	136	0.072	Fly
gland morphogenesis	GO:0022612	145	0.072
retinal cell programmed cell death	GO:0046666	25	0.072
retina development in camera type eye	GO:0060041	4	0.071
neuron neuron synaptic transmission	GO:0007270	14	0.071
imaginal disc derived wing morphogenesis	GO:0007476	337	0.071
negative regulation of mitotic cell cycle	GO:0045930	109	0.070
kidney morphogenesis	GO:0060993	3	0.070
single organism behavior	GO:0044708	391	0.070	Fly
regulation of behavior	GO:0050795	75	0.069	Fly
negative regulation of signaling	GO:0023057	219	0.069	Fly
morphogenesis of a branching structure	GO:0001763	45	0.069
cellular macromolecule localization	GO:0070727	220	0.068
camera type eye morphogenesis	GO:0048593	2	0.068
nucleoside triphosphate metabolic process	GO:0009141	120	0.068
regulation of cell cycle	GO:0051726	291	0.068
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.067
response to insulin	GO:0032868	29	0.067	Fly
activation of protein kinase activity	GO:0032147	12	0.067	Fly
regulation of cellular ketone metabolic process	GO:0010565	3	0.066
cellular response to extracellular stimulus	GO:0031668	64	0.065
cell division	GO:0051301	248	0.065	Fly
carboxylic acid transport	GO:0046942	18	0.065
regulation of protein metabolic process	GO:0051246	256	0.065	Fly
cellular response to growth factor stimulus	GO:0071363	30	0.065
nitrogen compound transport	GO:0071705	85	0.065
positive regulation of phosphorus metabolic process	GO:0010562	139	0.065	Fly
response to organonitrogen compound	GO:0010243	75	0.065	Fly
response to glucose	GO:0009749	2	0.064
cellular response to external stimulus	GO:0071496	66	0.064
developmental programmed cell death	GO:0010623	138	0.063
pigment metabolic process	GO:0042440	84	0.063
single organism catabolic process	GO:0044712	228	0.063
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.063
regulation of axonogenesis	GO:0050770	32	0.063
secretion by cell	GO:0032940	101	0.062
muscle structure development	GO:0061061	224	0.062	Fly
glycosyl compound metabolic process	GO:1901657	127	0.062
purine nucleoside metabolic process	GO:0042278	127	0.062
regulation of cellular amine metabolic process	GO:0033238	3	0.062
regulation of multicellular organism growth	GO:0040014	40	0.061	Fly
regulation of cell proliferation	GO:0042127	163	0.061	Fly
positive regulation of intracellular signal transduction	GO:1902533	116	0.061	Fly
negative regulation of developmental process	GO:0051093	201	0.061
regulation of compound eye retinal cell programmed cell death	GO:0046669	18	0.060
pigment biosynthetic process	GO:0046148	36	0.060
cellular response to dna damage stimulus	GO:0006974	223	0.060	Fly
purine ribonucleoside metabolic process	GO:0046128	127	0.060
response to endogenous stimulus	GO:0009719	119	0.060	Fly
cellular nitrogen compound catabolic process	GO:0044270	165	0.059
sex differentiation	GO:0007548	81	0.059	Fly
microtubule organizing center organization	GO:0031023	168	0.059
regulation of transferase activity	GO:0051338	58	0.059	Fly
cell adhesion	GO:0007155	136	0.058
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.057
olfactory learning	GO:0008355	56	0.057	Fly
circulatory system development	GO:0072359	82	0.056
phenol containing compound biosynthetic process	GO:0046189	6	0.055
regulation of epidermal growth factor receptor signaling pathway	GO:0042058	42	0.055
regulation of cell death	GO:0010941	173	0.055
nucleotide catabolic process	GO:0009166	109	0.055
cell cycle checkpoint	GO:0000075	95	0.055
specification of organ identity	GO:0010092	3	0.054
negative regulation of epidermal growth factor receptor signaling pathway	GO:0042059	29	0.053
regulation of cell cycle process	GO:0010564	181	0.053
response to growth factor	GO:0070848	31	0.052
cellular response to organic substance	GO:0071310	132	0.052	Fly
epithelial cell development	GO:0002064	274	0.052	Mouse
positive regulation of catalytic activity	GO:0043085	118	0.052	Fly
response to hexose	GO:0009746	3	0.052
regulation of cellular localization	GO:0060341	136	0.052
negative regulation of cell proliferation	GO:0008285	69	0.051
cell death	GO:0008219	279	0.051
response to hyperoxia	GO:0055093	3	0.051
regulation of mitotic cell cycle	GO:0007346	190	0.051
protein catabolic process	GO:0030163	101	0.051	Worm
negative regulation of cellular component organization	GO:0051129	108	0.051
regulation of synaptic transmission	GO:0050804	69	0.051	Fly
adult behavior	GO:0030534	137	0.051
cell growth	GO:0016049	108	0.050	Human Fly
response to extracellular stimulus	GO:0009991	116	0.050
detection of external stimulus	GO:0009581	66	0.050
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.049
programmed cell death	GO:0012501	257	0.049
response to decreased oxygen levels	GO:0036293	58	0.049	Fly
endomembrane system organization	GO:0010256	119	0.049
dna integrity checkpoint	GO:0031570	81	0.049
gonad development	GO:0008406	50	0.049	Fly
regulation of hydrolase activity	GO:0051336	97	0.049
establishment or maintenance of polarity of follicular epithelium	GO:0016334	26	0.049
tube morphogenesis	GO:0035239	191	0.049
reproductive behavior	GO:0019098	122	0.048	Fly
regulation of erbb signaling pathway	GO:1901184	42	0.048
epithelial cell proliferation	GO:0050673	15	0.048
regulation of cellular component biogenesis	GO:0044087	201	0.047
regulation of retinal cell programmed cell death	GO:0046668	18	0.047
regulation of catalytic activity	GO:0050790	185	0.047	Fly
regulation of protein phosphorylation	GO:0001932	64	0.047	Fly
body morphogenesis	GO:0010171	2	0.047
cellular protein catabolic process	GO:0044257	83	0.047
cellular amine metabolic process	GO:0044106	12	0.047
macromolecule catabolic process	GO:0009057	161	0.046	Worm
single organism cellular localization	GO:1902580	180	0.046
protein phosphorylation	GO:0006468	169	0.046
positive regulation of rna metabolic process	GO:0051254	271	0.046
establishment of protein localization	GO:0045184	163	0.046
muscle organ development	GO:0007517	127	0.045	Fly
negative regulation of cell cycle phase transition	GO:1901988	103	0.044
eggshell chorion assembly	GO:0007306	66	0.044
regulation of organelle organization	GO:0033043	196	0.043
stem cell proliferation	GO:0072089	88	0.043
developmental growth involved in morphogenesis	GO:0060560	65	0.043
morphogenesis of follicular epithelium	GO:0016333	36	0.043
embryonic axis specification	GO:0000578	107	0.043
nucleoside phosphate metabolic process	GO:0006753	162	0.042
positive regulation of developmental process	GO:0051094	143	0.042
gtp catabolic process	GO:0006184	72	0.042
cellular response to endogenous stimulus	GO:0071495	80	0.042	Fly
positive regulation of immune system process	GO:0002684	68	0.042
cranial nerve development	GO:0021545	1	0.042
cellular protein localization	GO:0034613	160	0.042
male gamete generation	GO:0048232	201	0.042	Mouse Fly
negative regulation of epithelial cell proliferation	GO:0050680	4	0.042
defense response	GO:0006952	300	0.041
positive regulation of protein phosphorylation	GO:0001934	34	0.041	Fly
amino acid transport	GO:0006865	12	0.041
alpha amino acid metabolic process	GO:1901605	20	0.041
organic cyclic compound catabolic process	GO:1901361	168	0.041
synaptic transmission	GO:0007268	288	0.041	Fly
negative regulation of kinase activity	GO:0033673	16	0.040
glycosyl compound catabolic process	GO:1901658	112	0.040
purine nucleotide catabolic process	GO:0006195	109	0.040
positive regulation of histone deacetylation	GO:0031065	2	0.040
dendrite morphogenesis	GO:0048813	199	0.040
organonitrogen compound biosynthetic process	GO:1901566	117	0.040
regulation of anatomical structure size	GO:0090066	163	0.040	Fly
salivary gland morphogenesis	GO:0007435	145	0.039
response to lipopolysaccharide	GO:0032496	4	0.039
renal system development	GO:0072001	72	0.039
centrosome organization	GO:0051297	163	0.039
cellular response to lipid	GO:0071396	20	0.039
embryonic pattern specification	GO:0009880	174	0.039
regulation of cell fate specification	GO:0042659	27	0.039
gland development	GO:0048732	191	0.039
regulation of muscle organ development	GO:0048634	13	0.039
signal transduction by phosphorylation	GO:0023014	107	0.039	Mouse Fly
negative regulation of programmed cell death	GO:0043069	72	0.038
positive regulation of gene expression	GO:0010628	290	0.038
cell cycle phase transition	GO:0044770	140	0.038
embryo development ending in birth or egg hatching	GO:0009792	152	0.038	Worm Fly
purine ribonucleoside catabolic process	GO:0046130	112	0.038
chemical homeostasis	GO:0048878	92	0.038
axon target recognition	GO:0007412	16	0.038
urogenital system development	GO:0001655	72	0.037
l glutamate import	GO:0051938	1	0.037
feeding behavior	GO:0007631	50	0.037	Fly
histone modification	GO:0016570	106	0.037
dorsal appendage formation	GO:0046843	47	0.037
positive regulation of lipid metabolic process	GO:0045834	4	0.037
regulation of protein modification process	GO:0031399	112	0.037	Fly
long term memory	GO:0007616	62	0.037
nephron development	GO:0072006	3	0.036
circadian rhythm	GO:0007623	105	0.036	Fly
regulation of ras protein signal transduction	GO:0046578	93	0.036
oocyte differentiation	GO:0009994	145	0.036
negative regulation of intracellular signal transduction	GO:1902532	57	0.035
guanosine containing compound metabolic process	GO:1901068	74	0.035
mitotic cytokinesis	GO:0000281	50	0.035
response to bacterium	GO:0009617	198	0.035
regulation of locomotion	GO:0040012	42	0.035
spindle assembly involved in mitosis	GO:0090307	50	0.035
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.035
organophosphate catabolic process	GO:0046434	112	0.035
spindle organization	GO:0007051	253	0.034
purine ribonucleotide catabolic process	GO:0009154	109	0.034
organic acid transport	GO:0015849	18	0.034
imaginal disc derived wing vein morphogenesis	GO:0008586	44	0.034
positive regulation of growth	GO:0045927	75	0.034	Fly
connective tissue development	GO:0061448	3	0.034
malpighian tubule development	GO:0072002	64	0.033
mitotic spindle organization	GO:0007052	220	0.033
cytoplasmic transport	GO:0016482	130	0.033
regulation of sequestering of calcium ion	GO:0051282	3	0.033
lateral inhibition	GO:0046331	206	0.033
cellular chemical homeostasis	GO:0055082	40	0.033
compound eye pigmentation	GO:0048072	17	0.032
negative regulation of erbb signaling pathway	GO:1901185	29	0.032
cellular protein complex assembly	GO:0043623	71	0.032
developmental induction	GO:0031128	3	0.032
protein targeting	GO:0006605	64	0.032
nucleoside triphosphate catabolic process	GO:0009143	108	0.032
regulation of map kinase activity	GO:0043405	17	0.031	Fly
embryonic morphogenesis	GO:0048598	206	0.031	Fly
branching involved in open tracheal system development	GO:0060446	45	0.031
anterior posterior axis specification embryo	GO:0008595	103	0.031
development of primary sexual characteristics	GO:0045137	50	0.031	Fly
nucleotide metabolic process	GO:0009117	161	0.031
ribonucleotide catabolic process	GO:0009261	109	0.031
blood circulation	GO:0008015	26	0.031
carbohydrate derivative catabolic process	GO:1901136	118	0.031
response to hydrogen peroxide	GO:0042542	11	0.031
dorsal ventral axis specification	GO:0009950	66	0.031
response to nitrogen compound	GO:1901698	90	0.031	Fly
regulation of developmental growth	GO:0048638	174	0.031	Fly
anterior posterior pattern specification	GO:0009952	136	0.030
stem cell maintenance	GO:0019827	67	0.030
multicellular organismal reproductive behavior	GO:0033057	110	0.030	Fly
transposition rna mediated	GO:0032197	3	0.030
ribonucleotide metabolic process	GO:0009259	145	0.030
epithelial cell proliferation involved in renal tubule morphogenesis	GO:2001013	11	0.030
regulation of organ formation	GO:0003156	3	0.030
response to temperature stimulus	GO:0009266	106	0.030
gastrulation	GO:0007369	70	0.030
regulation of embryonic development	GO:0045995	68	0.030

sev disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	cardiovascular system disease	DOID:1287	0	0.126
	disease of anatomical entity	DOID:7	0	0.126

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