IMP: Integrative Multi-species Prediction

Drosophila melanogaster

69 known processes

Nek2 (Dmel_CG17256)

CG17256 gene product from transcript CG17256-RA

(Aliases: Dmel\CG17256,NEK2,DmNek2,Dm Nek2,CG17256)

FLYBASE: FBgn0029970
Entrez: 31696
UniProtKB: Q9W3N8

Process Predictions
Disease Predictions

Nek2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
centrosome cycle	GO:0007098	137	0.976	Human
centrosome organization	GO:0051297	163	0.915	Human
centrosome duplication	GO:0051298	121	0.862
microtubule organizing center organization	GO:0031023	168	0.761	Human
mitotic spindle organization	GO:0007052	220	0.678	Mouse
spindle organization	GO:0007051	253	0.674	Mouse
mitotic nuclear division	GO:0007067	213	0.638
organelle localization	GO:0051640	148	0.527
mitotic spindle stabilization	GO:0043148	6	0.330
regulation of cell cycle	GO:0051726	291	0.325
mitotic sister chromatid segregation	GO:0000070	87	0.292	Mouse
single fertilization	GO:0007338	24	0.239
protein complex assembly	GO:0006461	200	0.235	Mouse
sister chromatid segregation	GO:0000819	92	0.234	Mouse
regulation of mitotic cell cycle	GO:0007346	190	0.224
regulation of mitosis	GO:0007088	56	0.204
microtubule anchoring	GO:0034453	11	0.195	Human
regulation of microtubule cytoskeleton organization	GO:0070507	41	0.186	Human
microtubule based movement	GO:0007018	51	0.181
negative regulation of cell cycle	GO:0045786	116	0.169
nucleus localization	GO:0051647	34	0.164
protein complex biogenesis	GO:0070271	201	0.157	Mouse
macromolecular complex assembly	GO:0065003	256	0.155	Mouse
spindle assembly involved in mitosis	GO:0090307	50	0.148	Mouse
single organism intracellular transport	GO:1902582	207	0.147
organelle assembly	GO:0070925	198	0.147	Mouse
pronuclear migration	GO:0035046	4	0.135
cytoskeleton dependent cytokinesis	GO:0061640	81	0.131
developmental maturation	GO:0021700	172	0.130
cytokinesis	GO:0000910	90	0.130
attachment of spindle microtubules to kinetochore	GO:0008608	5	0.130	Human
cell division	GO:0051301	248	0.128
maintenance of location in cell	GO:0051651	28	0.126	Human
mitotic cell cycle embryonic	GO:0045448	38	0.126
protein localization	GO:0008104	284	0.125	Human
oocyte differentiation	GO:0009994	145	0.123
meiotic cytokinesis	GO:0033206	33	0.121
nuclear division	GO:0000280	332	0.118
meiotic spindle organization	GO:0000212	36	0.112
cellular macromolecule localization	GO:0070727	220	0.111	Human
asymmetric cell division	GO:0008356	37	0.103
regulation of cell division	GO:0051302	72	0.101
regulation of microtubule based process	GO:0032886	49	0.097	Human
growth	GO:0040007	359	0.094
regulation of cytoskeleton organization	GO:0051493	89	0.093	Human
regulation of phosphorus metabolic process	GO:0051174	210	0.092
cytoskeleton dependent intracellular transport	GO:0030705	44	0.092
single organism cellular localization	GO:1902580	180	0.086
cell maturation	GO:0048469	144	0.084
maintenance of protein location in cell	GO:0032507	26	0.083	Human
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.081
cytokinetic process	GO:0032506	27	0.081
establishment of localization in cell	GO:0051649	402	0.081
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.078
regulation of synapse assembly	GO:0051963	94	0.077
mitotic spindle midzone assembly	GO:0051256	1	0.076
regulation of spindle elongation	GO:0032887	1	0.075
regulation of cell cycle phase transition	GO:1901987	130	0.075
spindle assembly involved in meiosis	GO:0090306	20	0.074
regulation of mitotic sister chromatid segregation	GO:0033047	28	0.072
establishment or maintenance of cell polarity	GO:0007163	167	0.065
regulation of organelle organization	GO:0033043	196	0.064
positive regulation of developmental process	GO:0051094	143	0.064
centrosome separation	GO:0051299	20	0.063	Human
regulation of developmental growth	GO:0048638	174	0.063
intracellular protein transport	GO:0006886	104	0.062
regulation of growth	GO:0040008	233	0.061
mitotic spindle elongation	GO:0000022	81	0.061
open tracheal system development	GO:0007424	204	0.061
appendage morphogenesis	GO:0035107	397	0.059
microtubule cytoskeleton organization involved in mitosis	GO:1902850	52	0.059	Mouse
negative regulation of mitotic cell cycle	GO:0045930	109	0.058
purine nucleoside metabolic process	GO:0042278	127	0.057
regulation of mitotic spindle organization	GO:0060236	9	0.057
compound eye development	GO:0048749	307	0.055
cellular macromolecular complex assembly	GO:0034622	153	0.054
positive regulation of protein localization to nucleus	GO:1900182	21	0.053
spermatogenesis	GO:0007283	200	0.053
nucleobase containing small molecule metabolic process	GO:0055086	174	0.052
mitotic cell cycle checkpoint	GO:0007093	88	0.052
male meiosis cytokinesis	GO:0007112	26	0.051
regulation of intracellular transport	GO:0032386	64	0.051
organelle fission	GO:0048285	340	0.050
sensory perception of mechanical stimulus	GO:0050954	72	0.050
nuclear migration	GO:0007097	20	0.049
positive regulation of phosphorus metabolic process	GO:0010562	139	0.049
chromosome segregation	GO:0007059	157	0.047	Human Mouse
endomembrane system organization	GO:0010256	119	0.046
axis specification	GO:0009798	167	0.046
establishment of organelle localization	GO:0051656	122	0.044
regulation of spindle organization	GO:0090224	17	0.044
intracellular transport	GO:0046907	228	0.044
mitotic sister chromatid separation	GO:0051306	30	0.044
protein localization to nucleus	GO:0034504	55	0.041
protein phosphorylation	GO:0006468	169	0.041
female meiotic division	GO:0007143	70	0.041
intracellular signal transduction	GO:0035556	300	0.041
carbohydrate derivative metabolic process	GO:1901135	217	0.041
spindle assembly involved in female meiosis	GO:0007056	14	0.040
regulation of synapse organization	GO:0050807	110	0.040
establishment of cell polarity	GO:0030010	40	0.040
microtubule polymerization or depolymerization	GO:0031109	39	0.040
female meiosis i	GO:0007144	8	0.040
oocyte dorsal ventral axis specification	GO:0007310	34	0.039
establishment of chromosome localization	GO:0051303	20	0.039
regulation of protein metabolic process	GO:0051246	256	0.039
purine containing compound catabolic process	GO:0072523	112	0.039
phosphorylation	GO:0016310	294	0.039
small molecule metabolic process	GO:0044281	305	0.038
imaginal disc derived appendage development	GO:0048737	399	0.038
nucleocytoplasmic transport	GO:0006913	72	0.038
regulation of multicellular organismal development	GO:2000026	414	0.038
organophosphate metabolic process	GO:0019637	195	0.038
catabolic process	GO:0009056	409	0.038
single organism biosynthetic process	GO:0044711	206	0.037
endocytosis	GO:0006897	310	0.037
nucleotide catabolic process	GO:0009166	109	0.036
meiotic nuclear division	GO:0007126	151	0.035
chromosome movement towards spindle pole	GO:0051305	4	0.035
purine ribonucleotide catabolic process	GO:0009154	109	0.035
regulation of mitotic sister chromatid separation	GO:0010965	28	0.035
dephosphorylation	GO:0016311	51	0.035
neuronal stem cell division	GO:0036445	35	0.035
mitotic centrosome separation	GO:0007100	8	0.035
organic substance catabolic process	GO:1901575	308	0.034
dendrite morphogenesis	GO:0048813	199	0.034
protein transport	GO:0015031	155	0.034
mitotic cell cycle phase transition	GO:0044772	138	0.034
microtubule polymerization	GO:0046785	15	0.034
protein localization to organelle	GO:0033365	82	0.033
ribose phosphate metabolic process	GO:0019693	145	0.033
positive regulation of transport	GO:0051050	92	0.033
positive regulation of multicellular organismal process	GO:0051240	143	0.033
syncytial blastoderm mitotic cell cycle	GO:0035186	21	0.033
carbohydrate derivative catabolic process	GO:1901136	118	0.032
spindle assembly	GO:0051225	80	0.032	Mouse
cellular protein localization	GO:0034613	160	0.032	Human
positive regulation of transcription factor import into nucleus	GO:0042993	19	0.032
positive regulation of mitotic sister chromatid separation	GO:1901970	10	0.032
positive regulation of protein transport	GO:0051222	37	0.031
mitotic cytokinesis	GO:0000281	50	0.031
protein dna complex assembly	GO:0065004	63	0.031
cellular nitrogen compound catabolic process	GO:0044270	165	0.031
regionalization	GO:0003002	416	0.031
regulation of cellular localization	GO:0060341	136	0.031	Human
response to heat	GO:0009408	63	0.030
gastrulation	GO:0007369	70	0.030
glycosyl compound metabolic process	GO:1901657	127	0.030
wnt signaling pathway	GO:0016055	98	0.030
equator specification	GO:0045317	4	0.030
regulation of protein import into nucleus	GO:0042306	28	0.030
regulation of cytoplasmic transport	GO:1903649	47	0.030
cell cycle comprising mitosis without cytokinesis	GO:0033301	25	0.029
male gamete generation	GO:0048232	201	0.029
protein import	GO:0017038	55	0.029
maintenance of protein location	GO:0045185	28	0.029	Human
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.028
nuclear transport	GO:0051169	72	0.028
centriole assembly	GO:0098534	24	0.028
intracellular mrna localization involved in anterior posterior axis specification	GO:0060811	53	0.028
positive regulation of phosphate metabolic process	GO:0045937	139	0.028
positive regulation of nucleocytoplasmic transport	GO:0046824	24	0.027
cytoplasmic transport	GO:0016482	130	0.027
myotube differentiation	GO:0014902	46	0.027
single organism nuclear import	GO:1902593	51	0.027
developmental growth	GO:0048589	280	0.027
mitotic chromosome condensation	GO:0007076	22	0.027
single organism catabolic process	GO:0044712	228	0.027
golgi organization	GO:0007030	66	0.027
protein polymerization	GO:0051258	42	0.026
regulation of intracellular protein transport	GO:0033157	46	0.026
muscle organ development	GO:0007517	127	0.026
regulation of nuclear division	GO:0051783	58	0.026
neuron remodeling	GO:0016322	29	0.026
regulation of cytokinesis	GO:0032465	3	0.026
meiosis i	GO:0007127	59	0.026
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.026
dorsal ventral pattern formation	GO:0009953	133	0.025
response to organophosphorus	GO:0046683	2	0.025
nucleoside triphosphate catabolic process	GO:0009143	108	0.025
ribonucleoside catabolic process	GO:0042454	112	0.024
regulation of hydrolase activity	GO:0051336	97	0.024
regulation of catalytic activity	GO:0050790	185	0.024
organonitrogen compound catabolic process	GO:1901565	128	0.024
positive regulation of response to stimulus	GO:0048584	323	0.024
regulation of mapk cascade	GO:0043408	92	0.024
regulation of cyclin dependent protein serine threonine kinase activity	GO:0000079	3	0.024
positive regulation of intracellular protein transport	GO:0090316	30	0.024
organic substance transport	GO:0071702	257	0.024
regulation of transcription factor import into nucleus	GO:0042990	22	0.024
metaphase anaphase transition of mitotic cell cycle	GO:0007091	28	0.023
regulation of protein localization to nucleus	GO:1900180	29	0.023
nucleoside phosphate catabolic process	GO:1901292	110	0.022
positive regulation of signaling	GO:0023056	243	0.022
negative regulation of cell cycle process	GO:0010948	109	0.022
metaphase anaphase transition of cell cycle	GO:0044784	28	0.022
negative regulation of cellular component organization	GO:0051129	108	0.022	Human
regulation of nucleocytoplasmic transport	GO:0046822	35	0.022
heterocycle catabolic process	GO:0046700	166	0.022
purine ribonucleoside catabolic process	GO:0046130	112	0.022
purine containing compound metabolic process	GO:0072521	155	0.022
neurological system process	GO:0050877	358	0.022
fat soluble vitamin metabolic process	GO:0006775	1	0.022
regulation of embryonic development	GO:0045995	68	0.022
purine nucleotide catabolic process	GO:0006195	109	0.022
programmed cell death	GO:0012501	257	0.022
cellular protein complex assembly	GO:0043623	71	0.021
glycosyl compound catabolic process	GO:1901658	112	0.021
jnk cascade	GO:0007254	50	0.021
centriole centriole cohesion	GO:0010457	5	0.021	Human
regulation of mitotic spindle elongation	GO:0032888	1	0.021
organophosphate catabolic process	GO:0046434	112	0.021
maintenance of location	GO:0051235	73	0.021	Human
cellular response to abiotic stimulus	GO:0071214	58	0.021
digestive tract morphogenesis	GO:0048546	127	0.021
positive regulation of mitotic metaphase anaphase transition	GO:0045842	10	0.021
regulation of mitotic metaphase anaphase transition	GO:0030071	26	0.020
protein import into nucleus	GO:0006606	51	0.020
regulation of cell cycle process	GO:0010564	181	0.020
negative regulation of developmental process	GO:0051093	201	0.020
proteasomal protein catabolic process	GO:0010498	59	0.020
microtubule based transport	GO:0010970	42	0.020
establishment of protein localization	GO:0045184	163	0.020
regulation of intracellular signal transduction	GO:1902531	236	0.020
positive regulation of catalytic activity	GO:0043085	118	0.020
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.019
regulation of nervous system development	GO:0051960	248	0.019
regulation of phosphate metabolic process	GO:0019220	210	0.019
tube development	GO:0035295	244	0.019
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.019
rna 3 end processing	GO:0031123	45	0.019
neuroblast proliferation	GO:0007405	74	0.019
cell adhesion	GO:0007155	136	0.019
spindle midzone assembly	GO:0051255	4	0.019
spindle assembly involved in female meiosis i	GO:0007057	5	0.019
nucleoside triphosphate metabolic process	GO:0009141	120	0.018
actin filament based process	GO:0030029	220	0.018
regulation of localization	GO:0032879	275	0.018	Human
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.018
cilium organization	GO:0044782	41	0.018
positive regulation of nfat protein import into nucleus	GO:0051533	16	0.018
embryonic pattern specification	GO:0009880	174	0.018
vesicle mediated transport	GO:0016192	381	0.018
dendrite development	GO:0016358	204	0.018
protein targeting	GO:0006605	64	0.018
ribonucleotide metabolic process	GO:0009259	145	0.018
synaptic transmission	GO:0007268	288	0.018
microtubule bundle formation	GO:0001578	27	0.018
spindle elongation	GO:0051231	83	0.018
aromatic compound catabolic process	GO:0019439	166	0.018
sensory perception	GO:0007600	196	0.018
segmentation	GO:0035282	207	0.018
ribonucleotide catabolic process	GO:0009261	109	0.018
purine ribonucleotide metabolic process	GO:0009150	145	0.018
nucleoside phosphate metabolic process	GO:0006753	162	0.017
mitotic g2 dna damage checkpoint	GO:0007095	69	0.017
sensory organ precursor cell division	GO:0045035	10	0.017
nuclear import	GO:0051170	51	0.017
mitotic g2 m transition checkpoint	GO:0044818	70	0.017
establishment of nucleus localization	GO:0040023	26	0.017
cell death	GO:0008219	279	0.017
cell motility	GO:0048870	251	0.017
actin filament organization	GO:0007015	126	0.017
axonogenesis	GO:0007409	290	0.017
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.017
organonitrogen compound metabolic process	GO:1901564	318	0.017
localization of cell	GO:0051674	257	0.017
regulation of transport	GO:0051049	181	0.017
regulation of cellular protein metabolic process	GO:0032268	243	0.016
mapk cascade	GO:0000165	107	0.016
forebrain development	GO:0030900	2	0.016
negative regulation of cell cycle g2 m phase transition	GO:1902750	8	0.016
eggshell formation	GO:0030703	105	0.016
axon development	GO:0061564	297	0.016
cellular protein modification process	GO:0006464	438	0.016
embryonic morphogenesis	GO:0048598	206	0.016
positive regulation of intracellular transport	GO:0032388	42	0.016
stem cell division	GO:0017145	69	0.016
regulation of epithelial cell proliferation	GO:0050678	4	0.015
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.015
regulation of protein localization	GO:0032880	76	0.015	Human
regulation of microtubule depolymerization	GO:0031114	24	0.015
cell growth	GO:0016049	108	0.015
response to temperature stimulus	GO:0009266	106	0.015
purine ribonucleoside metabolic process	GO:0046128	127	0.015
blastoderm segmentation	GO:0007350	159	0.015
nucleotide metabolic process	GO:0009117	161	0.015
positive regulation of protein metabolic process	GO:0051247	128	0.015
purine ribonucleoside monophosphate catabolic process	GO:0009169	38	0.015
regulation of locomotion	GO:0040012	42	0.015
wing disc morphogenesis	GO:0007472	344	0.015
negative regulation of g2 m transition of mitotic cell cycle	GO:0010972	8	0.015
salivary gland cell autophagic cell death	GO:0035071	83	0.015
negative regulation of cell cycle phase transition	GO:1901988	103	0.015
mitotic sister chromatid cohesion	GO:0007064	6	0.015
chromosome separation	GO:0051304	42	0.015
gtp metabolic process	GO:0046039	72	0.015
regulation of molecular function	GO:0065009	217	0.015	Mouse
negative regulation of microtubule depolymerization	GO:0007026	21	0.015
eye photoreceptor cell differentiation	GO:0001754	145	0.014	Zebrafish
neural precursor cell proliferation	GO:0061351	75	0.014
cellular catabolic process	GO:0044248	372	0.014
regulation of centrosome cycle	GO:0046605	7	0.014
macromolecule catabolic process	GO:0009057	161	0.014
purine nucleotide metabolic process	GO:0006163	146	0.014
positive regulation of metaphase anaphase transition of cell cycle	GO:1902101	10	0.014
neuromuscular junction development	GO:0007528	149	0.014
establishment of protein localization to organelle	GO:0072594	62	0.014
mitotic metaphase plate congression	GO:0007080	13	0.014
embryonic development via the syncytial blastoderm	GO:0001700	148	0.014
regulation of metaphase anaphase transition of cell cycle	GO:1902099	26	0.014
compound eye morphogenesis	GO:0001745	249	0.014
appendage development	GO:0048736	401	0.014
dna conformation change	GO:0071103	105	0.014
organic cyclic compound catabolic process	GO:1901361	168	0.014
positive regulation of catabolic process	GO:0009896	105	0.013
regulation of phosphorylation	GO:0042325	147	0.013
cellular protein complex disassembly	GO:0043624	35	0.013
establishment of spindle orientation	GO:0051294	18	0.013
germarium derived egg chamber formation	GO:0007293	101	0.013
synapse organization	GO:0050808	196	0.013
spindle assembly involved in male meiosis	GO:0007053	5	0.013
dna integrity checkpoint	GO:0031570	81	0.013
skeletal muscle organ development	GO:0060538	48	0.013
g2 m transition of mitotic cell cycle	GO:0000086	19	0.013
negative regulation of phosphorus metabolic process	GO:0010563	45	0.013
negative regulation of growth	GO:0045926	84	0.013
signal transduction by phosphorylation	GO:0023014	107	0.013
small gtpase mediated signal transduction	GO:0007264	88	0.013
regulation of cell morphogenesis	GO:0022604	163	0.013
carboxylic acid metabolic process	GO:0019752	92	0.013
eye morphogenesis	GO:0048592	260	0.013	Zebrafish
regulation of cell development	GO:0060284	215	0.012
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.012
cystoblast division	GO:0007282	10	0.012
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.012
positive regulation of hydrolase activity	GO:0051345	78	0.012
regulation of protein phosphorylation	GO:0001932	64	0.012
oocyte axis specification	GO:0007309	108	0.012
negative regulation of rna biosynthetic process	GO:1902679	240	0.012
synaptic growth at neuromuscular junction	GO:0051124	119	0.012
regulation of purine nucleotide catabolic process	GO:0033121	48	0.012
ribonucleoside metabolic process	GO:0009119	127	0.012
regulation of neuron projection development	GO:0010975	69	0.012
response to biotic stimulus	GO:0009607	294	0.012
asymmetric neuroblast division	GO:0055059	33	0.012
cytokinetic cell separation	GO:0000920	1	0.012
regulation of response to stress	GO:0080134	200	0.012
lipid metabolic process	GO:0006629	121	0.012
regulation of gtp catabolic process	GO:0033124	44	0.012
negative regulation of phosphorylation	GO:0042326	35	0.012
immune response activating signal transduction	GO:0002757	2	0.012
formation of anatomical boundary	GO:0048859	37	0.012
response to radiation	GO:0009314	155	0.012
regulation of cellular component biogenesis	GO:0044087	201	0.012
regulation of nucleotide metabolic process	GO:0006140	62	0.011
regulation of anatomical structure size	GO:0090066	163	0.011
positive regulation of phosphorylation	GO:0042327	87	0.011
negative regulation of rna metabolic process	GO:0051253	251	0.011
regulation of protein transport	GO:0051223	57	0.011
regulation of proteolysis	GO:0030162	87	0.011
tripartite regional subdivision	GO:0007351	103	0.011
calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules	GO:0016339	9	0.011
endomitotic cell cycle	GO:0007113	7	0.011
synapse assembly	GO:0007416	143	0.011
nucleoside metabolic process	GO:0009116	127	0.011
phagocytosis	GO:0006909	215	0.011
digestive tract development	GO:0048565	149	0.011
positive regulation of protein kinase activity	GO:0045860	25	0.011
regulation of programmed cell death	GO:0043067	152	0.011
cell cycle checkpoint	GO:0000075	95	0.011
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.011
nucleoside catabolic process	GO:0009164	112	0.011
response to ionizing radiation	GO:0010212	32	0.011
negative regulation of developmental growth	GO:0048640	64	0.011
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.011
response to oxidative stress	GO:0006979	86	0.011
single organism cell adhesion	GO:0098602	47	0.011
nucleoside monophosphate catabolic process	GO:0009125	39	0.011
protein modification process	GO:0036211	438	0.011
chromosome localization	GO:0050000	20	0.011
regulation of establishment of protein localization	GO:0070201	61	0.011
regulation of protein targeting	GO:1903533	29	0.011
regulation of kinase activity	GO:0043549	53	0.011
photoreceptor cell development	GO:0042461	96	0.010	Zebrafish
regulation of catabolic process	GO:0009894	170	0.010
oocyte maturation	GO:0001556	3	0.010
negative regulation of phosphate metabolic process	GO:0045936	45	0.010
actin cytoskeleton organization	GO:0030036	206	0.010
regulation of neurogenesis	GO:0050767	158	0.010
segment polarity determination	GO:0007367	25	0.010
protein targeting to nucleus	GO:0044744	51	0.010
chemotaxis	GO:0006935	249	0.010
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.010
cellular lipid metabolic process	GO:0044255	83	0.010
cell migration	GO:0016477	238	0.010
negative regulation of gene expression	GO:0010629	387	0.010

Nek2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.023
cancer	DOID:162	0.018
organ system cancer	DOID:0050686	0.018

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