Drosophila melanogaster

139 known processes

Topors (Dmel_CG15104)

Topoisomerase I-interacting protein

(Aliases: dTopors,dtopors,CG15104,Dmel\CG15104)

Topors biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
organelle localizationGO:00516401480.468
protein complex assemblyGO:00064612000.324
macromolecular complex assemblyGO:00650032560.318
protein complex biogenesisGO:00702712010.308
transcription from rna polymerase ii promoterGO:00063663680.289
positive regulation of nitrogen compound metabolic processGO:00511733540.247
Mouse
chromosome organizationGO:00512763600.213
cellular protein modification processGO:00064644380.162
positive regulation of nucleobase containing compound metabolic processGO:00459353320.159
Mouse
regulation of transcription from rna polymerase ii promoterGO:00063573780.155
dna metabolic processGO:00062592270.151
developmental programmed cell deathGO:00106231380.137
organelle fissionGO:00482853400.136
establishment of localization in cellGO:00516494020.119
protein modification processGO:00362114380.115
positive regulation of macromolecule metabolic processGO:00106044050.114
Human Mouse
negative regulation of macromolecule biosynthetic processGO:00105582700.107
spindle organizationGO:00070512530.099
organelle assemblyGO:00709251980.087
determination of adult lifespanGO:00083401370.087
transcription initiation from rna polymerase ii promoterGO:0006367250.076
rna polymerase ii transcriptional preinitiation complex assemblyGO:0051123200.075
cellular macromolecular complex assemblyGO:00346221530.072
protein dna complex assemblyGO:0065004630.071
phosphorylationGO:00163102940.067
cellular catabolic processGO:00442483720.065
dna templated transcriptional preinitiation complex assemblyGO:0070897200.065
protein dna complex subunit organizationGO:0071824860.065
histolysisGO:00075591020.065
cell proliferationGO:00082832990.064
Mouse
negative regulation of gene expressionGO:00106293870.063
photoreceptor cell differentiationGO:00465301700.063
single organism intracellular transportGO:19025822070.061
negative regulation of nitrogen compound metabolic processGO:00511722650.061
regulation of anatomical structure morphogenesisGO:00226032420.060
dna templated transcription initiationGO:0006352250.054
tissue deathGO:00162711020.054
positive regulation of cellular catabolic processGO:0031331950.052
positive regulation of canonical wnt signaling pathwayGO:009026370.051
nuclear divisionGO:00002803320.050
cytoplasmic transportGO:00164821300.046
negative regulation of nucleobase containing compound metabolic processGO:00459342610.045
regulation of protein phosphorylationGO:0001932640.044
spermatid differentiationGO:00485151140.043
positive regulation of cellular component organizationGO:00511301560.042
cellular protein localizationGO:00346131600.041
Human
intracellular transportGO:00469072280.040
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.039
covalent chromatin modificationGO:00165691060.038
regulation of dna replicationGO:0006275130.038
histone modificationGO:00165701060.037
catabolic processGO:00090564090.037
negative regulation of biosynthetic processGO:00098902770.037
single organism cellular localizationGO:19025801800.037
centrosome cycleGO:00070981370.035
establishment of organelle localizationGO:00516561220.035
regulation of protein metabolic processGO:00512462560.035
Human
positive regulation of biosynthetic processGO:00098913160.035
Mouse
sister chromatid segregationGO:0000819920.034
mitotic spindle organizationGO:00070522200.033
deathGO:00162652840.032
Human Mouse
nucleoside phosphate catabolic processGO:19012921100.032
meiotic cell cycle processGO:19030461320.032
axis specificationGO:00097981670.032
regulation of protein modification processGO:00313991120.032
Human
positive regulation of organelle organizationGO:0010638650.032
nucleotide metabolic processGO:00091171610.031
cellular macromolecule localizationGO:00707272200.031
Human
intracellular signal transductionGO:00355563000.030
Human Mouse
purine ribonucleoside triphosphate catabolic processGO:00092071080.030
positive regulation of phosphorus metabolic processGO:00105621390.030
negative regulation of transcription dna templatedGO:00458922370.030
negative regulation of rna metabolic processGO:00512532510.030
spermatogenesisGO:00072832000.029
mitotic nuclear divisionGO:00070672130.029
regulation of multicellular organismal developmentGO:20000264140.029
chromatin modificationGO:00165681470.029
vesicle mediated transportGO:00161923810.029
regulation of proteasomal protein catabolic processGO:0061136390.028
dorsal closureGO:0007391790.028
dna replicationGO:0006260480.028
positive regulation of phosphate metabolic processGO:00459371390.028
protein phosphorylationGO:00064681690.028
regulation of cellular component biogenesisGO:00440872010.027
organonitrogen compound metabolic processGO:19015643180.027
cellular macromolecule catabolic processGO:00442651360.027
organic substance catabolic processGO:19015753080.026
chromatin organizationGO:00063252070.026
protein transportGO:00150311550.026
cellular nitrogen compound catabolic processGO:00442701650.026
mitotic spindle elongationGO:0000022810.026
positive regulation of cellular component biogenesisGO:0044089800.025
purine ribonucleotide catabolic processGO:00091541090.025
eye developmentGO:00016543230.024
regulation of cell developmentGO:00602842150.023
salivary gland morphogenesisGO:00074351450.023
cellular amino acid metabolic processGO:0006520610.023
positive regulation of catabolic processGO:00098961050.023
localization of cellGO:00516742570.023
purine nucleoside metabolic processGO:00422781270.022
regulation of catabolic processGO:00098941700.022
gland developmentGO:00487321910.022
cellular response to chemical stimulusGO:00708871990.022
organic substance transportGO:00717022570.022
intracellular protein transportGO:00068861040.021
glycosyl compound catabolic processGO:19016581120.021
meiotic nuclear divisionGO:00071261510.021
regulation of cellular protein metabolic processGO:00322682430.021
Human
positive regulation of multicellular organismal processGO:00512401430.021
ribonucleoside triphosphate metabolic processGO:00091991190.021
purine nucleoside triphosphate catabolic processGO:00091461080.021
meiotic cell cycleGO:00513211710.021
spindle assembly involved in mitosisGO:0090307500.021
aromatic compound catabolic processGO:00194391660.020
regulation of nervous system developmentGO:00519602480.020
cellular response to dna damage stimulusGO:00069742230.020
regulation of phosphate metabolic processGO:00192202100.020
negative regulation of nucleic acid templated transcriptionGO:19035072400.020
ribose phosphate metabolic processGO:00196931450.020
regulation of cellular catabolic processGO:00313291570.019
regulation of phosphorus metabolic processGO:00511742100.019
multicellular organismal agingGO:00102591400.019
nucleoside triphosphate metabolic processGO:00091411200.019
regulation of intracellular signal transductionGO:19025312360.019
nuclear transportGO:0051169720.018
actin filament organizationGO:00070151260.018
regulation of cell differentiationGO:00455953020.018
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161540.018
Human
dorsal ventral axis specificationGO:0009950660.018
male gamete generationGO:00482322010.018
body morphogenesisGO:001017120.018
centrosome organizationGO:00512971630.018
organophosphate metabolic processGO:00196371950.017
response to organic cyclic compoundGO:0014070890.017
sensory organ morphogenesisGO:00905962600.017
dorsal ventral pattern formationGO:00099531330.017
negative regulation of rna biosynthetic processGO:19026792400.017
macromolecule catabolic processGO:00090571610.017
ras protein signal transductionGO:0007265880.016
nucleobase containing small molecule metabolic processGO:00550861740.016
regulation of cell morphogenesisGO:00226041630.016
negative regulation of cell cycleGO:00457861160.016
protein localizationGO:00081042840.016
Human
cell deathGO:00082192790.016
Human Mouse
regulation of protein complex assemblyGO:0043254420.016
salivary gland developmentGO:00074311620.016
actin cytoskeleton organizationGO:00300362060.016
positive regulation of cellular biosynthetic processGO:00313283160.016
Mouse
positive regulation of macromolecule biosynthetic processGO:00105572830.016
Mouse
regulation of ras protein signal transductionGO:0046578930.016
regulation of mitotic cell cycleGO:00073461900.016
purine nucleoside triphosphate metabolic processGO:00091441190.015
eye morphogenesisGO:00485922600.015
regulation of dna metabolic processGO:0051052340.015
respiratory system developmentGO:00605412130.015
nucleus localizationGO:0051647340.015
salivary gland cell autophagic cell deathGO:0035071830.015
organic cyclic compound catabolic processGO:19013611680.015
negative regulation of neurogenesisGO:0050768530.015
kinetochore organizationGO:005138390.015
mitotic cell cycle checkpointGO:0007093880.015
nucleoside catabolic processGO:00091641120.015
positive regulation of protein modification processGO:0031401580.015
Human
positive regulation of response to stimulusGO:00485843230.015
establishment or maintenance of cell polarityGO:00071631670.014
fertilizationGO:0009566260.014
regulation of cell cycle phase transitionGO:19019871300.014
mitochondrion localizationGO:0051646170.014
establishment of protein localizationGO:00451841630.014
regulation of cellular amino acid metabolic processGO:000652100.014
regulation of cellular ketone metabolic processGO:001056530.014
regulation of cytoskeleton organizationGO:0051493890.014
regulation of neuron differentiationGO:00456641030.014
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.014
positive regulation of rna biosynthetic processGO:19026802660.014
Mouse
mitotic sister chromatid segregationGO:0000070870.014
centriole replicationGO:0007099240.013
embryonic morphogenesisGO:00485982060.013
imaginal disc derived appendage developmentGO:00487373990.013
spermatid developmentGO:0007286980.013
nucleocytoplasmic transportGO:0006913720.013
meiotic chromosome segregationGO:0045132590.013
cellular protein complex assemblyGO:0043623710.013
proteasomal protein catabolic processGO:0010498590.013
Human
regulation of transferase activityGO:0051338580.013
Human
single organism catabolic processGO:00447122280.013
regulation of kinase activityGO:0043549530.013
nucleobase containing compound catabolic processGO:00346551650.013
ribonucleotide metabolic processGO:00092591450.013
autophagic cell deathGO:0048102830.012
golgi vesicle transportGO:0048193270.012
leg disc morphogenesisGO:0007478800.012
ribonucleoside triphosphate catabolic processGO:00092031080.012
molting cycleGO:0042303560.012
sperm motilityGO:0030317120.012
multi multicellular organism processGO:00447061230.012
regionalizationGO:00030024160.012
agingGO:00075681430.012
cell cycle comprising mitosis without cytokinesisGO:0033301250.012
female meiotic divisionGO:0007143700.012
positive regulation of protein complex assemblyGO:0031334220.012
heterocycle catabolic processGO:00467001660.012
negative regulation of cell differentiationGO:00455961430.012
carbohydrate derivative catabolic processGO:19011361180.012
regulation of neurogenesisGO:00507671580.011
negative regulation of cellular biosynthetic processGO:00313272770.011
membrane organizationGO:00610241120.011
digestive system developmentGO:00551231490.011
purine ribonucleoside triphosphate metabolic processGO:00092051190.011
establishment or maintenance of cytoskeleton polarityGO:0030952440.011
embryo development ending in birth or egg hatchingGO:00097921520.011
synaptic vesicle endocytosisGO:0048488280.011
purine nucleotide metabolic processGO:00061631460.011
negative regulation of cellular metabolic processGO:00313243820.011
homeostatic processGO:00425921990.011
negative regulation of cellular component organizationGO:00511291080.011
regulation of cytoplasmic transportGO:1903649470.011
purine ribonucleotide metabolic processGO:00091501450.011
nucleoside triphosphate catabolic processGO:00091431080.011
regulation of multi organism processGO:00439001310.011
regulation of cellular amine metabolic processGO:003323830.011
microtubule organizing center organizationGO:00310231680.011
dna packagingGO:0006323910.010
exocrine system developmentGO:00352721620.010
ribonucleoside metabolic processGO:00091191270.010
regulation of establishment of protein localizationGO:0070201610.010
purine ribonucleoside catabolic processGO:00461301120.010
regulation of response to external stimulusGO:00321011150.010
positive regulation of cellular amine metabolic processGO:003324000.010
proteolysis involved in cellular protein catabolic processGO:0051603830.010

Topors disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:1456600.015
cancerDOID:16200.012
organ system cancerDOID:005068600.012
disease of anatomical entityDOID:700.010
Human