IMP: Integrative Multi-species Prediction

Drosophila melanogaster

51 known processes

Cad74A (Dmel_CG6445)

CG6445 gene product from transcript CG6445-RB

(Aliases: Dmel\CG6445,CT20086,CG6445,cad74A,Cad74B,DCad74B)

FLYBASE: FBgn0036715
Entrez: 39936
UniProtKB: Q9VVG0

Process Predictions
Disease Predictions

Cad74A biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
ovarian follicle cell development	GO:0030707	248	0.678
epithelial cell differentiation	GO:0030855	322	0.354
epithelial cell development	GO:0002064	274	0.236
chorion containing eggshell formation	GO:0007304	105	0.232
columnar cuboidal epithelial cell development	GO:0002066	249	0.167
organonitrogen compound metabolic process	GO:1901564	318	0.128
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.111
cellular component assembly involved in morphogenesis	GO:0010927	151	0.095
small molecule metabolic process	GO:0044281	305	0.082
cilium assembly	GO:0042384	38	0.080
compound eye development	GO:0048749	307	0.079	Fly
cell projection assembly	GO:0030031	94	0.074
dorsal appendage formation	GO:0046843	47	0.074
eggshell formation	GO:0030703	105	0.074
sensory organ morphogenesis	GO:0090596	260	0.073	Fly
tissue morphogenesis	GO:0048729	297	0.073	Fly
eye morphogenesis	GO:0048592	260	0.073	Fly
regionalization	GO:0003002	416	0.069	Fly
carbohydrate derivative metabolic process	GO:1901135	217	0.068
establishment or maintenance of cell polarity	GO:0007163	167	0.067	Fly
regulation of tube architecture open tracheal system	GO:0035152	68	0.063	Fly
intracellular signal transduction	GO:0035556	300	0.058	Fly
compound eye morphogenesis	GO:0001745	249	0.058	Fly
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.056
lateral inhibition	GO:0046331	206	0.055
cellular protein modification process	GO:0006464	438	0.055
photoreceptor cell differentiation	GO:0046530	170	0.053	Fly
protein modification process	GO:0036211	438	0.052
cell division	GO:0051301	248	0.050
morphogenesis of an epithelium	GO:0002009	276	0.050	Fly
nucleoside metabolic process	GO:0009116	127	0.046
regulation of cellular component biogenesis	GO:0044087	201	0.046	Fly
regulation of growth	GO:0040008	233	0.045
response to abiotic stimulus	GO:0009628	341	0.045
ameboidal type cell migration	GO:0001667	151	0.044
tissue migration	GO:0090130	155	0.043
organophosphate metabolic process	GO:0019637	195	0.041
ribose phosphate metabolic process	GO:0019693	145	0.041
regulation of cell differentiation	GO:0045595	302	0.039	Fly
immune system process	GO:0002376	347	0.039
cilium organization	GO:0044782	41	0.038
appendage development	GO:0048736	401	0.038
nucleoside catabolic process	GO:0009164	112	0.038
nucleoside triphosphate metabolic process	GO:0009141	120	0.038
purine nucleoside catabolic process	GO:0006152	112	0.038
cell motility	GO:0048870	251	0.037
regulation of cell development	GO:0060284	215	0.037	Fly
nucleotide metabolic process	GO:0009117	161	0.037
single organism catabolic process	GO:0044712	228	0.037
eye photoreceptor cell differentiation	GO:0001754	145	0.036	Fly
ovarian follicle cell migration	GO:0007297	121	0.035
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.035
post embryonic appendage morphogenesis	GO:0035120	385	0.035
body morphogenesis	GO:0010171	2	0.034
regulation of catalytic activity	GO:0050790	185	0.034
phosphorylation	GO:0016310	294	0.033
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.033
embryonic pattern specification	GO:0009880	174	0.033	Fly
establishment of tissue polarity	GO:0007164	87	0.032	Fly
regulation of phosphorus metabolic process	GO:0051174	210	0.032
eggshell chorion assembly	GO:0007306	66	0.032
regulation of immune system process	GO:0002682	176	0.032
cellular catabolic process	GO:0044248	372	0.032
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.032
regulation of multi organism process	GO:0043900	131	0.031
positive regulation of cell communication	GO:0010647	250	0.031
nucleoside phosphate metabolic process	GO:0006753	162	0.031
cell maturation	GO:0048469	144	0.031
carboxylic acid metabolic process	GO:0019752	92	0.031
regulation of multicellular organismal development	GO:2000026	414	0.031	Fly
regulation of notch signaling pathway	GO:0008593	100	0.030	Fly
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.030
eye development	GO:0001654	323	0.030	Fly
regulation of cellular protein metabolic process	GO:0032268	243	0.029
positive regulation of multicellular organismal process	GO:0051240	143	0.029
nucleobase containing small molecule metabolic process	GO:0055086	174	0.029
positive regulation of signaling	GO:0023056	243	0.029
cytoplasmic transport nurse cell to oocyte	GO:0007303	12	0.029
endocytosis	GO:0006897	310	0.029
response to organic substance	GO:0010033	284	0.028
regulation of molecular function	GO:0065009	217	0.028
purine ribonucleoside metabolic process	GO:0046128	127	0.028
protein phosphorylation	GO:0006468	169	0.028
localization of cell	GO:0051674	257	0.027
oxoacid metabolic process	GO:0043436	103	0.027
purine containing compound metabolic process	GO:0072521	155	0.027
establishment of localization in cell	GO:0051649	402	0.027
appendage morphogenesis	GO:0035107	397	0.027
nucleoside triphosphate catabolic process	GO:0009143	108	0.027
purine nucleotide metabolic process	GO:0006163	146	0.027
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.027
notch signaling pathway	GO:0007219	120	0.027	Fly
positive regulation of catalytic activity	GO:0043085	118	0.027
epithelium migration	GO:0090132	148	0.027
establishment of planar polarity	GO:0001736	87	0.026	Fly
cytoplasmic transport	GO:0016482	130	0.026
anterior posterior pattern specification	GO:0009952	136	0.026
positive regulation of phosphate metabolic process	GO:0045937	139	0.026
positive regulation of response to stimulus	GO:0048584	323	0.026
kidney development	GO:0001822	3	0.026
glycosyl compound catabolic process	GO:1901658	112	0.026
cell proliferation	GO:0008283	299	0.026
organelle localization	GO:0051640	148	0.026
dna metabolic process	GO:0006259	227	0.026
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.026
cellular amino acid metabolic process	GO:0006520	61	0.026
positive regulation of developmental process	GO:0051094	143	0.025
purine nucleoside metabolic process	GO:0042278	127	0.025
negative regulation of response to stimulus	GO:0048585	258	0.025	Fly
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.025
organic substance catabolic process	GO:1901575	308	0.025
ribonucleoside catabolic process	GO:0042454	112	0.025
cilium morphogenesis	GO:0060271	39	0.025
compound eye photoreceptor cell differentiation	GO:0001751	140	0.025	Fly
organic acid metabolic process	GO:0006082	103	0.025
regulation of cellular amine metabolic process	GO:0033238	3	0.025
forebrain development	GO:0030900	2	0.025
imaginal disc derived appendage development	GO:0048737	399	0.024
blastoderm segmentation	GO:0007350	159	0.024	Fly
biological adhesion	GO:0022610	138	0.024
aromatic compound catabolic process	GO:0019439	166	0.024
positive regulation of cellular catabolic process	GO:0031331	95	0.024
organic cyclic compound catabolic process	GO:1901361	168	0.024
cell migration	GO:0016477	238	0.024
gland development	GO:0048732	191	0.024
axonogenesis	GO:0007409	290	0.024	Fly
camera type eye development	GO:0043010	4	0.024
regulation of protein modification process	GO:0031399	112	0.023
regulation of phosphate metabolic process	GO:0019220	210	0.023
cell death	GO:0008219	279	0.023
response to bacterium	GO:0009617	198	0.023
nephron development	GO:0072006	3	0.023
positive regulation of macromolecule metabolic process	GO:0010604	405	0.023
single organismal cell cell adhesion	GO:0016337	45	0.023
cell adhesion	GO:0007155	136	0.023
regulation of neurogenesis	GO:0050767	158	0.023	Fly
positive regulation of hydrolase activity	GO:0051345	78	0.023
cellular macromolecule localization	GO:0070727	220	0.023
purine ribonucleotide metabolic process	GO:0009150	145	0.023
growth	GO:0040007	359	0.023
programmed cell death	GO:0012501	257	0.022
ion transport	GO:0006811	145	0.022
epithelial cell migration	GO:0010631	148	0.022
actin filament based process	GO:0030029	220	0.022
nucleotide catabolic process	GO:0009166	109	0.022
actin cytoskeleton organization	GO:0030036	206	0.022
ribonucleoside metabolic process	GO:0009119	127	0.022
regulation of immune response	GO:0050776	118	0.022
catabolic process	GO:0009056	409	0.022
wing disc morphogenesis	GO:0007472	344	0.022
morphogenesis of a polarized epithelium	GO:0001738	93	0.022	Fly
positive regulation of phosphorus metabolic process	GO:0010562	139	0.022
neurological system process	GO:0050877	358	0.021
kidney epithelium development	GO:0072073	3	0.021
embryonic morphogenesis	GO:0048598	206	0.021
regulation of intracellular signal transduction	GO:1902531	236	0.021
ribonucleotide metabolic process	GO:0009259	145	0.021
establishment of organelle localization	GO:0051656	122	0.021
positive regulation of molecular function	GO:0044093	136	0.021
cellular ketone metabolic process	GO:0042180	24	0.021
heterocycle catabolic process	GO:0046700	166	0.021
gland morphogenesis	GO:0022612	145	0.021
nucleobase containing compound catabolic process	GO:0034655	165	0.021
regulation of protein metabolic process	GO:0051246	256	0.021
purine ribonucleoside catabolic process	GO:0046130	112	0.021
defense response to other organism	GO:0098542	225	0.021
negative regulation of cytoskeleton organization	GO:0051494	30	0.021
negative regulation of signaling	GO:0023057	219	0.020	Fly
positive regulation of compound eye retinal cell programmed cell death	GO:0046672	9	0.020
developmental growth	GO:0048589	280	0.020
single organism biosynthetic process	GO:0044711	206	0.020
wing disc pattern formation	GO:0035222	66	0.020
phagocytosis	GO:0006909	215	0.020
organelle fission	GO:0048285	340	0.020
carbohydrate derivative catabolic process	GO:1901136	118	0.020
mesenchymal cell differentiation	GO:0048762	1	0.020
positive regulation of signal transduction	GO:0009967	223	0.020
nucleoside phosphate catabolic process	GO:1901292	110	0.020
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.020
regulation of cellular amino acid metabolic process	GO:0006521	0	0.020
regulation of hydrolase activity	GO:0051336	97	0.020
purine containing compound catabolic process	GO:0072523	112	0.019
detection of stimulus	GO:0051606	156	0.019
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.019
single organism cell adhesion	GO:0098602	47	0.019
organonitrogen compound biosynthetic process	GO:1901566	117	0.019
response to other organism	GO:0051707	293	0.019
oocyte anterior posterior axis specification	GO:0007314	72	0.019
death	GO:0016265	284	0.019
organonitrogen compound catabolic process	GO:1901565	128	0.019
glycosyl compound metabolic process	GO:1901657	127	0.019
anatomical structure homeostasis	GO:0060249	97	0.019
sensory perception	GO:0007600	196	0.019
regulation of phosphorylation	GO:0042325	147	0.019
response to ionizing radiation	GO:0010212	32	0.018
regulation of cellular ketone metabolic process	GO:0010565	3	0.018
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.018
regulation of cell death	GO:0010941	173	0.018
purine ribonucleotide catabolic process	GO:0009154	109	0.018
developmental maturation	GO:0021700	172	0.018
sensory perception of mechanical stimulus	GO:0050954	72	0.018
positive regulation of cell differentiation	GO:0045597	64	0.018
response to lipopolysaccharide	GO:0032496	4	0.018
imaginal disc derived wing morphogenesis	GO:0007476	337	0.018
anion homeostasis	GO:0055081	3	0.018
oocyte construction	GO:0007308	112	0.018
vesicle mediated transport	GO:0016192	381	0.018
humoral immune response	GO:0006959	117	0.018
regulation of localization	GO:0032879	275	0.017
oocyte differentiation	GO:0009994	145	0.017
microtubule polymerization or depolymerization	GO:0031109	39	0.017
adult behavior	GO:0030534	137	0.017
cellular nitrogen compound catabolic process	GO:0044270	165	0.017
segmentation	GO:0035282	207	0.017	Fly
ras protein signal transduction	GO:0007265	88	0.017
macromolecular complex assembly	GO:0065003	256	0.017
open tracheal system development	GO:0007424	204	0.017	Fly
organophosphate catabolic process	GO:0046434	112	0.017
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.017
salivary gland morphogenesis	GO:0007435	145	0.017
response to external biotic stimulus	GO:0043207	293	0.017
cytoskeleton dependent cytokinesis	GO:0061640	81	0.016
regulation of nervous system development	GO:0051960	248	0.016	Fly
spindle organization	GO:0007051	253	0.016
regulation of programmed cell death	GO:0043067	152	0.016
small gtpase mediated signal transduction	GO:0007264	88	0.016
cellular component disassembly	GO:0022411	46	0.016
imaginal disc pattern formation	GO:0007447	91	0.016
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.016
cellular protein complex disassembly	GO:0043624	35	0.016
positive regulation of phosphorylation	GO:0042327	87	0.016
homeostatic process	GO:0042592	199	0.016
regulation of cell proliferation	GO:0042127	163	0.016
negative regulation of cell communication	GO:0010648	223	0.016	Fly
positive regulation of transport	GO:0051050	92	0.016
negative regulation of cell cycle	GO:0045786	116	0.016
regulation of cytoskeleton organization	GO:0051493	89	0.016
immune response regulating signaling pathway	GO:0002764	2	0.016
retina development in camera type eye	GO:0060041	4	0.015
response to oxygen containing compound	GO:1901700	200	0.015
hair cell differentiation	GO:0035315	47	0.015
morphogenesis of follicular epithelium	GO:0016333	36	0.015
protein localization	GO:0008104	284	0.015
purine nucleotide catabolic process	GO:0006195	109	0.015
nephron epithelium development	GO:0072009	3	0.015
regulation of cell projection organization	GO:0031344	92	0.015	Fly
protein complex disassembly	GO:0043241	36	0.015
immune effector process	GO:0002252	98	0.015
centrosome organization	GO:0051297	163	0.015
gtp metabolic process	GO:0046039	72	0.015
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.014	Fly
oocyte development	GO:0048599	124	0.014
negative regulation of programmed cell death	GO:0043069	72	0.014
ribonucleotide catabolic process	GO:0009261	109	0.014
mapk cascade	GO:0000165	107	0.014
cytokinesis	GO:0000910	90	0.014
cellular amine metabolic process	GO:0044106	12	0.014
guanosine containing compound metabolic process	GO:1901068	74	0.014
oocyte axis specification	GO:0007309	108	0.014
single organism cellular localization	GO:1902580	180	0.014
positive regulation of mapk cascade	GO:0043410	63	0.014
regulation of tube length open tracheal system	GO:0035159	24	0.014	Fly
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.014
protein modification by small protein conjugation or removal	GO:0070647	106	0.014
response to biotic stimulus	GO:0009607	294	0.014
positive regulation of cell motility	GO:2000147	3	0.014
positive regulation of cell migration	GO:0030335	2	0.014
intracellular transport	GO:0046907	228	0.014
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.014
chaeta development	GO:0022416	97	0.014
regulation of developmental growth	GO:0048638	174	0.014
mitotic cytokinesis	GO:0000281	50	0.014
positive regulation of cell development	GO:0010720	61	0.014
regulation of ras protein signal transduction	GO:0046578	93	0.014
positive regulation of retinal cell programmed cell death	GO:0046670	9	0.014
single organism intracellular transport	GO:1902582	207	0.014
gtp catabolic process	GO:0006184	72	0.014
camera type eye morphogenesis	GO:0048593	2	0.014
developmental programmed cell death	GO:0010623	138	0.014
proteolysis	GO:0006508	192	0.014
regulation of microtubule based process	GO:0032886	49	0.014
regulation of cell cycle	GO:0051726	291	0.014
regulation of catabolic process	GO:0009894	170	0.014
microtubule based transport	GO:0010970	42	0.014
negative regulation of notch signaling pathway	GO:0045746	41	0.013	Fly
anterior posterior axis specification	GO:0009948	109	0.013
exocrine system development	GO:0035272	162	0.013
synaptic transmission	GO:0007268	288	0.013	Fly
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.013
monocarboxylic acid transport	GO:0015718	3	0.013
positive regulation of cell death	GO:0010942	69	0.013
amine metabolic process	GO:0009308	12	0.013
actomyosin contractile ring organization	GO:0044837	10	0.013
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	4	0.013
taxis	GO:0042330	304	0.013	Fly
transcription from rna polymerase ii promoter	GO:0006366	368	0.013
signal transduction by phosphorylation	GO:0023014	107	0.013
defense response	GO:0006952	300	0.013
innate immune response	GO:0045087	144	0.013
protein complex biogenesis	GO:0070271	201	0.013
respiratory system development	GO:0060541	213	0.013	Fly
regulation of cell cycle process	GO:0010564	181	0.013
negative regulation of signal transduction	GO:0009968	206	0.013	Fly
cellular lipid metabolic process	GO:0044255	83	0.013
mesenchymal cell development	GO:0014031	1	0.013
organic substance transport	GO:0071702	257	0.013
positive regulation of nucleotide catabolic process	GO:0030813	46	0.013
regulation of mapk cascade	GO:0043408	92	0.012
lipid metabolic process	GO:0006629	121	0.012
sensory perception of sound	GO:0007605	56	0.012
positive regulation of intracellular signal transduction	GO:1902533	116	0.012
dna methylation	GO:0006306	4	0.012
cuticle development	GO:0042335	86	0.012
kidney morphogenesis	GO:0060993	3	0.012
positive regulation of immune system process	GO:0002684	68	0.012
chaeta morphogenesis	GO:0008407	42	0.012
regulation of actin filament based process	GO:0032970	42	0.012
circulatory system process	GO:0003013	37	0.012
g protein coupled receptor signaling pathway	GO:0007186	136	0.012
positive regulation of protein metabolic process	GO:0051247	128	0.012
negative regulation of multicellular organismal process	GO:0051241	142	0.012
negative regulation of gene expression	GO:0010629	387	0.012
telencephalon development	GO:0021537	2	0.012
hematopoietic progenitor cell differentiation	GO:0002244	1	0.012
salivary gland development	GO:0007431	162	0.012
stem cell differentiation	GO:0048863	117	0.012
dorsal ventral pattern formation	GO:0009953	133	0.012
negative regulation of cellular component organization	GO:0051129	108	0.012
regulation of apoptotic process	GO:0042981	130	0.012
establishment or maintenance of cytoskeleton polarity	GO:0030952	44	0.012
defense response to bacterium	GO:0042742	178	0.012
rna methylation	GO:0001510	2	0.012
heterochromatin organization	GO:0070828	25	0.012
mitotic spindle organization	GO:0007052	220	0.012
positive regulation of immune response	GO:0050778	63	0.012
cellular response to dna damage stimulus	GO:0006974	223	0.012
embryonic axis specification	GO:0000578	107	0.012
immune response activating signal transduction	GO:0002757	2	0.012
positive regulation of cellular protein metabolic process	GO:0032270	118	0.012
positive regulation of gene expression	GO:0010628	290	0.012
response to radiation	GO:0009314	155	0.012
connective tissue development	GO:0061448	3	0.012
nuclear division	GO:0000280	332	0.012
tube morphogenesis	GO:0035239	191	0.012
rhythmic process	GO:0048511	106	0.011
regulation of anatomical structure morphogenesis	GO:0022603	242	0.011	Fly
pigmentation	GO:0043473	75	0.011
leg disc development	GO:0035218	92	0.011
axon development	GO:0061564	297	0.011	Fly
epidermis development	GO:0008544	65	0.011
skeletal muscle fiber development	GO:0048741	3	0.011
tube development	GO:0035295	244	0.011
mitotic nuclear division	GO:0007067	213	0.011
positive regulation of purine nucleotide catabolic process	GO:0033123	46	0.011
dna methylation or demethylation	GO:0044728	4	0.011
regulation of transport	GO:0051049	181	0.011
pole plasm assembly	GO:0007315	61	0.011
peptide metabolic process	GO:0006518	80	0.011
regulation of endocytosis	GO:0030100	37	0.011
positive regulation of protein modification process	GO:0031401	58	0.011
protein depolymerization	GO:0051261	31	0.011
regulation of epithelial cell differentiation	GO:0030856	4	0.011
regulation of cellular localization	GO:0060341	136	0.011
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.011
regulation of organelle organization	GO:0033043	196	0.011
imaginal disc derived leg morphogenesis	GO:0007480	80	0.011
regulation of reproductive process	GO:2000241	54	0.011
neuron projection guidance	GO:0097485	241	0.011	Fly
autophagic cell death	GO:0048102	83	0.011
molting cycle chitin based cuticle	GO:0007591	56	0.010
chemotaxis	GO:0006935	249	0.010	Fly
water homeostasis	GO:0030104	3	0.010
regulation of mitotic cell cycle	GO:0007346	190	0.010
positive regulation of gtp catabolic process	GO:0033126	43	0.010
protein heterooligomerization	GO:0051291	4	0.010
positive regulation of biosynthetic process	GO:0009891	316	0.010
protein complex assembly	GO:0006461	200	0.010
regulation of cell substrate adhesion	GO:0010810	2	0.010
regulation of neuron differentiation	GO:0045664	103	0.010	Fly
non sensory hair organization	GO:0035316	47	0.010
mrna processing	GO:0006397	104	0.010
regulation of actin cytoskeleton organization	GO:0032956	42	0.010
somatic muscle development	GO:0007525	66	0.010
regulation of cell morphogenesis	GO:0022604	163	0.010	Fly
positive regulation of transcription dna templated	GO:0045893	266	0.010
ribonucleoside monophosphate catabolic process	GO:0009158	39	0.010
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.010
cellular response to chemical stimulus	GO:0070887	199	0.010
positive regulation of cellular amine metabolic process	GO:0033240	0	0.010

Cad74A disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.027
nervous system disease	DOID:863	0.013
disease of metabolism	DOID:0014667	0.010
inherited metabolic disorder	DOID:655	0.010

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