Drosophila melanogaster

18 known processes

Def (Dmel_CG1385)

Defensin

(Aliases: CG1385,Dmel\CG1385,143607_at,def,DEF)

Def biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
response to external biotic stimulusGO:00432072930.078
defense response to other organismGO:00985422250.076
response to biotic stimulusGO:00096072940.075
response to other organismGO:00517072930.070
defense responseGO:00069523000.067
immune system processGO:00023763470.066
organonitrogen compound metabolic processGO:19015643180.055
defense response to bacteriumGO:00427421780.051
appendage developmentGO:00487364010.047
response to bacteriumGO:00096171980.045
immune responseGO:00069552460.045
positive regulation of response to stimulusGO:00485843230.044
imaginal disc derived appendage morphogenesisGO:00351143950.043
imaginal disc derived wing morphogenesisGO:00074763370.042
antibacterial humoral responseGO:0019731440.042
response to abiotic stimulusGO:00096283410.039
imaginal disc derived appendage developmentGO:00487373990.038
antimicrobial humoral responseGO:0019730990.038
small molecule metabolic processGO:00442813050.038
innate immune responseGO:00450871440.038
deathGO:00162652840.037
wing disc morphogenesisGO:00074723440.037
cell deathGO:00082192790.036
appendage morphogenesisGO:00351073970.036
post embryonic appendage morphogenesisGO:00351203850.035
neurological system processGO:00508773580.034
humoral immune responseGO:00069591170.034
catabolic processGO:00090564090.033
defense response to gram negative bacteriumGO:0050829940.033
organic substance catabolic processGO:19015753080.033
programmed cell deathGO:00125012570.032
body morphogenesisGO:001017120.032
cellular catabolic processGO:00442483720.032
nuclear divisionGO:00002803320.032
defense response to gram positive bacteriumGO:0050830410.031
response to organic substanceGO:00100332840.030
oxoacid metabolic processGO:00434361030.030
regulation of response to stressGO:00801342000.030
single organism behaviorGO:00447083910.030
response to lipopolysaccharideGO:003249640.030
positive regulation of cellular biosynthetic processGO:00313283160.029
positive regulation of biosynthetic processGO:00098913160.029
salivary gland developmentGO:00074311620.028
carboxylic acid metabolic processGO:0019752920.028
organic acid metabolic processGO:00060821030.028
exocrine system developmentGO:00352721620.028
vesicle mediated transportGO:00161923810.028
gland morphogenesisGO:00226121450.028
regulation of defense responseGO:00313471020.027
regulation of multicellular organismal developmentGO:20000264140.027
regionalizationGO:00030024160.027
protein modification processGO:00362114380.027
regulation of cell cycleGO:00517262910.026
columnar cuboidal epithelial cell differentiationGO:00020652560.026
epithelial cell developmentGO:00020642740.026
single organism catabolic processGO:00447122280.026
endocytosisGO:00068973100.026
epithelial cell differentiationGO:00308553220.026
tissue deathGO:00162711020.026
negative regulation of response to stimulusGO:00485852580.026
negative regulation of cellular metabolic processGO:00313243820.025
regulation of immune responseGO:00507761180.025
positive regulation of nitrogen compound metabolic processGO:00511733540.025
columnar cuboidal epithelial cell developmentGO:00020662490.025
response to organophosphorusGO:004668320.025
compound eye developmentGO:00487493070.025
cellular protein modification processGO:00064644380.024
negative regulation of gene expressionGO:00106293870.024
phosphorylationGO:00163102940.024
ethanolamine containing compound metabolic processGO:004243940.024
regulation of cellular amine metabolic processGO:003323830.024
single organism biosynthetic processGO:00447112060.024
cellular amino acid metabolic processGO:0006520610.024
carbohydrate derivative metabolic processGO:19011352170.023
cellular amine metabolic processGO:0044106120.023
taxisGO:00423303040.023
establishment of localization in cellGO:00516494020.023
amine metabolic processGO:0009308120.023
pattern recognition receptor signaling pathwayGO:000222120.023
macromolecule catabolic processGO:00090571610.023
phagocytosisGO:00069092150.023
killing of cells of other organismGO:003164010.023
positive regulation of cell communicationGO:00106472500.023
regulation of localizationGO:00328792750.023
histolysisGO:00075591020.023
positive regulation of macromolecule metabolic processGO:00106044050.023
organelle fissionGO:00482853400.023
sterol homeostasisGO:005509240.023
camera type eye developmentGO:004301040.023
eye developmentGO:00016543230.022
ovarian follicle cell developmentGO:00307072480.022
positive regulation of signalingGO:00230562430.022
organic substance transportGO:00717022570.022
autophagic cell deathGO:0048102830.022
intracellular signal transductionGO:00355563000.022
positive regulation of immune responseGO:0050778630.022
regulation of immune system processGO:00026821760.022
forebrain developmentGO:003090020.022
peptide metabolic processGO:0006518800.022
salivary gland cell autophagic cell deathGO:0035071830.022
negative regulation of signalingGO:00230572190.021
positive regulation of defense responseGO:0031349590.021
regulation of cellular ketone metabolic processGO:001056530.021
developmental programmed cell deathGO:00106231380.021
activation of innate immune responseGO:000221840.021
regulation of cell differentiationGO:00455953020.021
salivary gland morphogenesisGO:00074351450.021
chromosome segregationGO:00070591570.021
open tracheal system developmentGO:00074242040.021
spindle organizationGO:00070512530.021
transcription from rna polymerase ii promoterGO:00063663680.021
gland developmentGO:00487321910.021
lateral inhibitionGO:00463312060.020
protein localizationGO:00081042840.020
sensory perception of chemical stimulusGO:00076061160.020
negative regulation of cell communicationGO:00106482230.020
regulation of cellular amino acid metabolic processGO:000652100.020
positive regulation of nucleobase containing compound metabolic processGO:00459353320.020
positive regulation of signal transductionGO:00099672230.020
cellular response to chemical stimulusGO:00708871990.020
kidney developmentGO:000182230.020
multi organism behaviorGO:00517051750.020
growthGO:00400073590.020
anion homeostasisGO:005508130.020
macromolecular complex assemblyGO:00650032560.020
matingGO:00076181200.020
organonitrogen compound catabolic processGO:19015651280.019
chromosome organizationGO:00512763600.019
response to oxygen containing compoundGO:19017002000.019
salivary gland histolysisGO:0035070880.019
developmental growthGO:00485892800.019
negative regulation of signal transductionGO:00099682060.019
male gamete generationGO:00482322010.019
cell cell signaling involved in cell fate commitmentGO:00451682100.019
positive regulation of rna biosynthetic processGO:19026802660.019
organophosphate metabolic processGO:00196371950.019
response to monosaccharideGO:003428440.019
mitotic spindle organizationGO:00070522200.019
detection of stimulusGO:00516061560.018
lipopolysaccharide mediated signaling pathwayGO:003166310.018
respiratory system developmentGO:00605412130.018
regulation of intracellular signal transductionGO:19025312360.018
cell divisionGO:00513012480.018
cellular ketone metabolic processGO:0042180240.018
immune response regulating signaling pathwayGO:000276420.018
multi multicellular organism processGO:00447061230.018
organelle assemblyGO:00709251980.018
proteolysisGO:00065081920.018
negative regulation of developmental processGO:00510932010.018
localization of cellGO:00516742570.018
intracellular transportGO:00469072280.018
regulation of phosphorus metabolic processGO:00511742100.018
sensory perceptionGO:00076001960.018
positive regulation of cell migrationGO:003033520.018
cell proliferationGO:00082832990.018
segmentationGO:00352822070.018
synaptic transmissionGO:00072682880.018
response to radiationGO:00093141550.018
telencephalon developmentGO:002153720.018
positive regulation of macromolecule biosynthetic processGO:00105572830.018
regulation of molecular functionGO:00650092170.018
homeostatic processGO:00425921990.018
neutral lipid biosynthetic processGO:004646020.018
positive regulation of gene expressionGO:00106282900.018
mitotic nuclear divisionGO:00070672130.018
axon developmentGO:00615642970.018
response to hexoseGO:000974630.017
aromatic compound catabolic processGO:00194391660.017
regulation of cellular component biogenesisGO:00440872010.017
cellular response to lipopolysaccharideGO:007122230.017
rna processingGO:00063961470.017
regulation of transportGO:00510491810.017
response to glucoseGO:000974920.017
positive regulation of cell motilityGO:200014730.017
negative regulation of nitrogen compound metabolic processGO:00511722650.017
negative regulation of macromolecule biosynthetic processGO:00105582700.017
ras protein signal transductionGO:0007265880.017
cellular response to dna damage stimulusGO:00069742230.017
compound eye morphogenesisGO:00017452490.017
dendrite developmentGO:00163582040.017
cellular response to molecule of bacterial originGO:007121930.017
connective tissue developmentGO:006144830.017
nucleobase containing small molecule metabolic processGO:00550861740.017
cell cycle phase transitionGO:00447701400.017
single organism intracellular transportGO:19025822070.017
positive regulation of nucleic acid templated transcriptionGO:19035082660.017
negative regulation of biosynthetic processGO:00098902770.017
regulation of anatomical structure sizeGO:00900661630.017
cell motilityGO:00488702510.017
adult behaviorGO:00305341370.017
negative regulation of cellular biosynthetic processGO:00313272770.016
hormone catabolic processGO:004244730.016
multicellular organismal agingGO:00102591400.016
regulation of transcription from rna polymerase ii promoterGO:00063573780.016
axonogenesisGO:00074092900.016
mitotic cell cycle phase transitionGO:00447721380.016
innate immune response activating signal transductionGO:000275820.016
steroid catabolic processGO:000670610.016
regulation of innate immune responseGO:0045088710.016
small gtpase mediated signal transductionGO:0007264880.016
xenobiotic catabolic processGO:004217810.016
nucleoside phosphate metabolic processGO:00067531620.016
transmembrane transportGO:00550851390.016
protein complex assemblyGO:00064612000.016
protein complex biogenesisGO:00702712010.016
regulation of cellular protein metabolic processGO:00322682430.016
negative regulation of nucleic acid templated transcriptionGO:19035072400.016
glycerolipid catabolic processGO:004650330.016
apoptotic processGO:00069151590.016
positive regulation of rna metabolic processGO:00512542710.016
nucleotide metabolic processGO:00091171610.016
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.016
cellular nitrogen compound catabolic processGO:00442701650.016
cellular component assembly involved in morphogenesisGO:00109271510.016
acylglycerol catabolic processGO:004646430.016
regulation of phosphate metabolic processGO:00192202100.016
immune response activating signal transductionGO:000275720.016
positive regulation of transcription dna templatedGO:00458932660.016
negative regulation of nucleobase containing compound metabolic processGO:00459342610.016
nucleobase containing compound catabolic processGO:00346551650.016
multi organism reproductive behaviorGO:00447051210.016
axon guidanceGO:00074112330.015
neuron projection guidanceGO:00974852410.015
spermatogenesisGO:00072832000.015
regulation of protein metabolic processGO:00512462560.015
chemotaxisGO:00069352490.015
reproductive behaviorGO:00190981220.015
regulation of epithelial cell proliferationGO:005067840.015
vitamin biosynthetic processGO:000911010.015
regulation of cell cycle phase transitionGO:19019871300.015
regulation of mitotic cell cycle phase transitionGO:19019901300.015
organic cyclic compound catabolic processGO:19013611680.015
embryonic pattern specificationGO:00098801740.015
sensory organ morphogenesisGO:00905962600.015
ion transportGO:00068111450.015
cell migrationGO:00164772380.015
regulation of catalytic activityGO:00507901850.015
locomotory behaviorGO:00076261760.015
g protein coupled receptor signaling pathwayGO:00071861360.015
axis specificationGO:00097981670.015
heterocycle catabolic processGO:00467001660.015
gene silencingGO:00164581380.015
ameboidal type cell migrationGO:00016671510.015
central nervous system developmentGO:00074172010.015
sensory perception of smellGO:0007608800.015
purine ribonucleotide metabolic processGO:00091501450.015
chemosensory behaviorGO:00076351060.015
regulation of mitotic cell cycleGO:00073461900.015
fat soluble vitamin metabolic processGO:000677510.014
negative regulation of rna metabolic processGO:00512532510.014
hindbrain developmentGO:003090220.014
cellular macromolecule catabolic processGO:00442651360.014
antimicrobial peptide productionGO:0002775460.014
cellular amide metabolic processGO:0043603800.014
meiotic cell cycleGO:00513211710.014
organonitrogen compound biosynthetic processGO:19015661170.014
regulation of cell developmentGO:00602842150.014
response to fungusGO:0009620500.014
morphogenesis of an epitheliumGO:00020092760.014
negative regulation of cell differentiationGO:00455961430.014
negative regulation of rna biosynthetic processGO:19026792400.014
establishment of protein localizationGO:00451841630.014
cell recognitionGO:00080371020.014
enzyme linked receptor protein signaling pathwayGO:00071671790.014
eye morphogenesisGO:00485922600.014
regulation of cellular catabolic processGO:00313291570.014
regulation of nervous system developmentGO:00519602480.014
protein phosphorylationGO:00064681690.014
single organism cellular localizationGO:19025801800.014
kidney epithelium developmentGO:007207330.014
positive regulation of cellular amine metabolic processGO:003324000.014
purine containing compound metabolic processGO:00725211550.014
carbohydrate derivative catabolic processGO:19011361180.014
regulation of cell deathGO:00109411730.014
developmental maturationGO:00217001720.014
polyol biosynthetic processGO:004617330.014
regulation of cell cycle processGO:00105641810.014
blastoderm segmentationGO:00073501590.014
negative regulation of transcription dna templatedGO:00458922370.014
tissue morphogenesisGO:00487292970.014
cation transportGO:00068121100.014
tube developmentGO:00352952440.014
cellular response to organic substanceGO:00713101320.014
positive regulation of lipid storageGO:001088440.014
purine nucleotide metabolic processGO:00061631460.014
negative regulation of multicellular organismal processGO:00512411420.014
response to endogenous stimulusGO:00097191190.014
posttranscriptional regulation of gene expressionGO:00106081450.014
l glutamate importGO:005193810.014
response to light stimulusGO:00094161240.014
vitamin metabolic processGO:000676620.014
regulation of growthGO:00400082330.014
triglyceride biosynthetic processGO:001943220.014
cholesterol homeostasisGO:004263230.013
nephron epithelium developmentGO:007200930.013
microtubule organizing center organizationGO:00310231680.013
mesenchymal cell differentiationGO:004876210.013
regulation of synapse structure and activityGO:00508031280.013
ribose phosphate metabolic processGO:00196931450.013
purine ribonucleoside metabolic processGO:00461281270.013
protein transportGO:00150311550.013
biological adhesionGO:00226101380.013
regulation of antimicrobial peptide biosynthetic processGO:0002805380.013
dorsal ventral pattern formationGO:00099531330.013
regulation of mapk cascadeGO:0043408920.013
limb developmentGO:006017310.013
phosphatidylethanolamine metabolic processGO:004633710.013
nucleoside metabolic processGO:00091161270.013
regulation of anatomical structure morphogenesisGO:00226032420.013
multicellular organismal reproductive behaviorGO:00330571100.013
defense response to fungusGO:0050832480.013
fat soluble vitamin biosynthetic processGO:004236210.013
acetylcholine metabolic processGO:000829120.013
retina development in camera type eyeGO:006004140.013
regulation of catabolic processGO:00098941700.013
dendrite morphogenesisGO:00488131990.013
positive regulation of cellular amino acid metabolic processGO:004576400.013
dna metabolic processGO:00062592270.013
amide biosynthetic processGO:0043604420.013
ribonucleotide metabolic processGO:00092591450.013
mating behaviorGO:00076171060.013
regulation of gene expression epigeneticGO:00400291280.013
positive regulation of molecular functionGO:00440931360.013
regulation of programmed cell deathGO:00430671520.013
cellular macromolecule localizationGO:00707272200.013
camera type eye morphogenesisGO:004859320.013
glycosyl compound metabolic processGO:19016571270.013
regulation of multi organism processGO:00439001310.013
benzene containing compound metabolic processGO:004253730.013
chromatin organizationGO:00063252070.013
regulation of sequestering of triglycerideGO:001088930.013
cellular protein localizationGO:00346131600.013
eggshell formationGO:00307031050.013
establishment or maintenance of cell polarityGO:00071631670.013
nephron developmentGO:007200630.013
neuron recognitionGO:00080381010.013
meiotic cell cycle processGO:19030461320.013
centrosome organizationGO:00512971630.013
wnt signaling pathwayGO:0016055980.013
antimicrobial peptide biosynthetic processGO:0002777380.013
response to nitrogen compoundGO:1901698900.013
ribonucleoside metabolic processGO:00091191270.013
neutral lipid catabolic processGO:004646130.013
cellular response to ethanolGO:007136140.013
positive regulation of phosphorus metabolic processGO:00105621390.013
acetate ester metabolic processGO:190061920.013
detection of chemical stimulusGO:0009593930.012
cellular macromolecular complex assemblyGO:00346221530.012
detection of chemical stimulus involved in sensory perceptionGO:0050907750.012
purine nucleotide catabolic processGO:00061951090.012
positive regulation of catalytic activityGO:00430851180.012
regulation of cell proliferationGO:00421271630.012
regulation of organelle organizationGO:00330431960.012
ribonucleoside triphosphate metabolic processGO:00091991190.012
compound eye photoreceptor cell differentiationGO:00017511400.012
regulation of phosphorylationGO:00423251470.012
amine catabolic processGO:000931010.012
olfactory behaviorGO:0042048970.012
signal transduction by phosphorylationGO:00230141070.012
ribonucleotide catabolic processGO:00092611090.012
phospholipid homeostasisGO:005509110.012
purine nucleoside metabolic processGO:00422781270.012
determination of adult lifespanGO:00083401370.012
regulation of apoptotic processGO:00429811300.012
regulation of synapse organizationGO:00508071100.012
rna localizationGO:00064031150.012
nucleoside phosphate catabolic processGO:19012921100.012
estrogen metabolic processGO:000821010.012
cellular response to biotic stimulusGO:007121640.012
somatic muscle developmentGO:0007525660.012
response to temperature stimulusGO:00092661060.012
regulation of developmental growthGO:00486381740.012
response to copper ionGO:004668840.012
regulation of epithelial cell differentiationGO:003085640.012
glycosyl compound catabolic processGO:19016581120.012
neurotransmitter metabolic processGO:004213320.012
lipid metabolic processGO:00066291210.012
chaeta developmentGO:0022416970.012
purine nucleoside triphosphate metabolic processGO:00091441190.012
synapse assemblyGO:00074161430.012
maintenance of locationGO:0051235730.012
actin filament based processGO:00300292200.012
regulation of lipid transportGO:003236830.012
medium chain fatty acid metabolic processGO:005179110.012
triglyceride catabolic processGO:001943330.012
mesenchymal cell developmentGO:001403110.012
spermatid differentiationGO:00485151140.012
synapse organizationGO:00508081960.012
cytoplasmic transportGO:00164821300.012
actin cytoskeleton organizationGO:00300362060.012
acylglycerol biosynthetic processGO:004646320.012
immune effector processGO:0002252980.012
purine ribonucleoside catabolic processGO:00461301120.012
nucleoside triphosphate metabolic processGO:00091411200.012
protein modification by small protein conjugation or removalGO:00706471060.012
cell projection assemblyGO:0030031940.012
kidney morphogenesisGO:006099330.012
mrna metabolic processGO:00160711240.012
ribonucleoside catabolic processGO:00424541120.012
purine nucleoside triphosphate catabolic processGO:00091461080.012
response to nutrient levelsGO:00316671140.012
limb morphogenesisGO:003510810.012
mitotic sister chromatid segregationGO:0000070870.012
regulation of cell substrate adhesionGO:001081020.012
photoreceptor cell differentiationGO:00465301700.012
purine ribonucleotide catabolic processGO:00091541090.012
regulation of defense response to bacteriumGO:1900424300.012
eye photoreceptor cell differentiationGO:00017541450.012
negative regulation of cell cycle processGO:00109481090.012
female meiotic divisionGO:0007143700.012
sister chromatid segregationGO:0000819920.012
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.012
cellular homeostasisGO:0019725800.012
purine containing compound catabolic processGO:00725231120.012
hematopoietic progenitor cell differentiationGO:000224410.012
positive regulation of antimicrobial peptide productionGO:0002225280.012
choline metabolic processGO:001969510.012
cholesterol transportGO:003030120.011
regulation of cellular localizationGO:00603411360.011
positive regulation of catabolic processGO:00098961050.011
secondary metabolic processGO:0019748750.011
detection of stimulus involved in sensory perceptionGO:0050906920.011
purine ribonucleoside triphosphate metabolic processGO:00092051190.011
mrna processingGO:00063971040.011
purine nucleoside catabolic processGO:00061521120.011
positive regulation of antimicrobial humoral responseGO:0002760280.011
positive regulation of multicellular organismal processGO:00512401430.011
monocarboxylic acid transportGO:001571830.011
l amino acid importGO:004309220.011
meiotic nuclear divisionGO:00071261510.011
mapk cascadeGO:00001651070.011
agingGO:00075681430.011
cilium assemblyGO:0042384380.011
regulation of i kappab kinase nf kappab signalingGO:004312220.011
organophosphate catabolic processGO:00464341120.011
response to mercury ionGO:004668930.011
peptidyl threonine phosphorylationGO:001810720.011
pigmentationGO:0043473750.011
regulation of synapse assemblyGO:0051963940.011
apoptotic process involved in morphogenesisGO:006056130.011
nucleotide catabolic processGO:00091661090.011
regulation of antimicrobial peptide productionGO:0002784440.011
protein catabolic processGO:00301631010.011
anterior posterior pattern specificationGO:00099521360.011
cell cycle checkpointGO:0000075950.011
chromatin remodelingGO:0006338720.011
cellular response to hexose stimulusGO:007133110.011
positive regulation of apoptotic signaling pathwayGO:200123540.011
melanization defense responseGO:0035006450.011
androgen metabolic processGO:000820910.011
positive regulation of immune system processGO:0002684680.011
neuromuscular junction developmentGO:00075281490.011
glutathione metabolic processGO:0006749370.011
pyridine containing compound metabolic processGO:007252430.011
tube morphogenesisGO:00352391910.011
ribonucleoside triphosphate catabolic processGO:00092031080.011
endomembrane system organizationGO:00102561190.011
peripheral nervous system developmentGO:0007422520.011
choline catabolic processGO:004242610.011
head developmentGO:00603221350.011
cell adhesionGO:00071551360.011
spinal cord developmentGO:002151010.011
regulation of ras protein signal transductionGO:0046578930.011
notch signaling pathwayGO:00072191200.011
muscle structure developmentGO:00610612240.011
sulfur compound metabolic processGO:0006790590.011
regulation of antibacterial peptide productionGO:0002786220.011
drinking behaviorGO:004275620.011
ion transmembrane transportGO:00342201220.011

Def disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.042
disease of metabolismDOID:001466700.022
nervous system diseaseDOID:86300.019
inherited metabolic disorderDOID:65500.018
cardiovascular system diseaseDOID:128700.017
acquired metabolic diseaseDOID:006015800.016
vascular diseaseDOID:17800.016
artery diseaseDOID:005082800.016
hypertensionDOID:1076300.016
glucose metabolism diseaseDOID:419400.014
diabetes mellitusDOID:935100.014
carbohydrate metabolism diseaseDOID:005001300.014
hypotrichosisDOID:453500.013
integumentary system diseaseDOID:1600.013
hair diseaseDOID:42100.013
type 2 diabetes mellitusDOID:935200.012
musculoskeletal system diseaseDOID:1700.012
essential hypertensionDOID:1082500.012
urinary system diseaseDOID:1800.012
sensory system diseaseDOID:005015500.012
kidney diseaseDOID:55700.012
disease of cellular proliferationDOID:1456600.012
cancerDOID:16200.012
organ system cancerDOID:005068600.011
eye diseaseDOID:561400.011
eye and adnexa diseaseDOID:149200.011