IMP: Integrative Multi-species Prediction

Drosophila melanogaster

122 known processes

Sh (Dmel_CG12348)

Shaker

(Aliases: EKO,Dmel\CG12348,Sha,Shw,BcDNA:GH03046,V-I,SH,sh,CG17860,CG12348,CG7640,F-c,minisleep)

Entrez: 32780
FLYBASE: FBgn0003380
UniProtKB: M9PHG6
UniProtKB: M9NGK2
UniProtKB: E1JJQ5
UniProtKB: P08510
UniProtKB: M9PJQ4

Process Predictions
Disease Predictions

Sh biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
ion transport	GO:0006811	145	0.489
cation transport	GO:0006812	110	0.423
cation transmembrane transport	GO:0098655	88	0.421
locomotory behavior	GO:0007626	176	0.363
ion transmembrane transport	GO:0034220	122	0.292
response to abiotic stimulus	GO:0009628	341	0.167
synaptic transmission	GO:0007268	288	0.158
learning	GO:0007612	75	0.154
response to organic substance	GO:0010033	284	0.143	Rat
adult behavior	GO:0030534	137	0.138
single organism behavior	GO:0044708	391	0.136
synapse organization	GO:0050808	196	0.130
transmembrane transport	GO:0055085	139	0.129
establishment of localization in cell	GO:0051649	402	0.125
metal ion transport	GO:0030001	74	0.109	Human Mouse Rat Fly
adult locomotory behavior	GO:0008344	76	0.107
associative learning	GO:0008306	65	0.104
sensory organ morphogenesis	GO:0090596	260	0.100
axonogenesis	GO:0007409	290	0.093
sleep	GO:0030431	49	0.091
monovalent inorganic cation transport	GO:0015672	40	0.085	Human Mouse Rat Fly
neurological system process	GO:0050877	358	0.083
inorganic cation transmembrane transport	GO:0098662	61	0.082	Human Mouse Rat Fly
eye development	GO:0001654	323	0.077
telencephalon development	GO:0021537	2	0.076
compound eye development	GO:0048749	307	0.075
learning or memory	GO:0007611	141	0.072
cognition	GO:0050890	141	0.071
neuromuscular synaptic transmission	GO:0007274	67	0.068
eye morphogenesis	GO:0048592	260	0.061
protein complex biogenesis	GO:0070271	201	0.060	Rat
forebrain development	GO:0030900	2	0.060
response to light stimulus	GO:0009416	124	0.059
regulation of excitatory postsynaptic membrane potential	GO:0060079	3	0.058
regulation of synaptic transmission	GO:0050804	69	0.055
cellular response to nutrient levels	GO:0031669	62	0.050
homeostatic process	GO:0042592	199	0.050	Rat
response to other organism	GO:0051707	293	0.048
protein localization	GO:0008104	284	0.048
cellular response to lipopolysaccharide	GO:0071222	3	0.046
endocytosis	GO:0006897	310	0.045
cell adhesion	GO:0007155	136	0.044
circulatory system development	GO:0072359	82	0.043
response to external biotic stimulus	GO:0043207	293	0.042
response to sterol	GO:0036314	34	0.041
negative regulation of cellular metabolic process	GO:0031324	382	0.039
muscle structure development	GO:0061061	224	0.038
developmental growth	GO:0048589	280	0.037
anatomical structure homeostasis	GO:0060249	97	0.037
protein complex assembly	GO:0006461	200	0.037	Rat
axon development	GO:0061564	297	0.037
photoreceptor cell differentiation	GO:0046530	170	0.036
response to lipopolysaccharide	GO:0032496	4	0.036
cellular response to chemical stimulus	GO:0070887	199	0.036
organonitrogen compound metabolic process	GO:1901564	318	0.035
cellular response to dna damage stimulus	GO:0006974	223	0.035
dna metabolic process	GO:0006259	227	0.035
response to alkaloid	GO:0043279	26	0.035
eye photoreceptor cell differentiation	GO:0001754	145	0.034
central nervous system development	GO:0007417	201	0.033
vesicle mediated transport	GO:0016192	381	0.033
response to alcohol	GO:0097305	95	0.033
protein heterooligomerization	GO:0051291	4	0.033
cellular response to molecule of bacterial origin	GO:0071219	3	0.033
flight behavior	GO:0007629	26	0.033
regulation of membrane potential	GO:0042391	35	0.032
membrane depolarization	GO:0051899	4	0.032
cellular homeostasis	GO:0019725	80	0.032	Rat
eye photoreceptor cell development	GO:0042462	81	0.032
circadian sleep wake cycle process	GO:0022410	24	0.032
dna repair	GO:0006281	54	0.031
regulation of nervous system development	GO:0051960	248	0.031
response to insecticide	GO:0017085	14	0.031
inorganic ion transmembrane transport	GO:0098660	73	0.031	Human Mouse Rat Fly
transcription from rna polymerase ii promoter	GO:0006366	368	0.030
dendrite development	GO:0016358	204	0.030
regulation of molecular function	GO:0065009	217	0.030
circadian sleep wake cycle	GO:0042745	28	0.029
circadian behavior	GO:0048512	76	0.029
single organism biosynthetic process	GO:0044711	206	0.029
cellular response to biotic stimulus	GO:0071216	4	0.029
positive regulation of biosynthetic process	GO:0009891	316	0.028
dendrite morphogenesis	GO:0048813	199	0.028
macromolecular complex assembly	GO:0065003	256	0.028	Rat
sensory perception of chemical stimulus	GO:0007606	116	0.028
potassium ion transport	GO:0006813	20	0.028	Human Mouse Rat Fly
heart development	GO:0007507	82	0.028
neuron recognition	GO:0008038	101	0.027
muscle organ development	GO:0007517	127	0.027
circadian sleep wake cycle sleep	GO:0050802	23	0.027
response to nitrogen compound	GO:1901698	90	0.027
compound eye morphogenesis	GO:0001745	249	0.027
organic substance transport	GO:0071702	257	0.027
response to oxygen containing compound	GO:1901700	200	0.026	Rat
cellular response to organic substance	GO:0071310	132	0.025
mrna processing	GO:0006397	104	0.025
phagocytosis	GO:0006909	215	0.025
response to organonitrogen compound	GO:0010243	75	0.025
axon guidance	GO:0007411	233	0.024
positive regulation of rna biosynthetic process	GO:1902680	266	0.024
response to toxic substance	GO:0009636	22	0.024
establishment of protein localization	GO:0045184	163	0.024
rhythmic process	GO:0048511	106	0.024
muscle contraction	GO:0006936	13	0.024
response to decreased oxygen levels	GO:0036293	58	0.023	Rat
brain development	GO:0007420	120	0.023
response to endogenous stimulus	GO:0009719	119	0.023
nuclear division	GO:0000280	332	0.023
behavioral response to ethanol	GO:0048149	49	0.022
imaginal disc derived wing morphogenesis	GO:0007476	337	0.022
biological adhesion	GO:0022610	138	0.022
membrane organization	GO:0061024	112	0.022
regulation of phosphorylation	GO:0042325	147	0.022
response to oxidative stress	GO:0006979	86	0.021	Rat
regulation of multicellular organismal development	GO:2000026	414	0.021
regulation of localization	GO:0032879	275	0.021
negative regulation of developmental process	GO:0051093	201	0.021
organelle fission	GO:0048285	340	0.021
single organism membrane organization	GO:0044802	93	0.020
regulation of cell cycle	GO:0051726	291	0.020	Rat
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.020
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.020
divalent metal ion transport	GO:0070838	26	0.020
striated muscle cell differentiation	GO:0051146	90	0.020
regulation of ion transport	GO:0043269	39	0.020
regulation of transport	GO:0051049	181	0.020
positive regulation of cellular biosynthetic process	GO:0031328	316	0.020
protein transport	GO:0015031	155	0.020
oxoacid metabolic process	GO:0043436	103	0.019
aging	GO:0007568	143	0.019
molting cycle	GO:0042303	56	0.019
regulation of secretion	GO:0051046	44	0.019
establishment or maintenance of cell polarity	GO:0007163	167	0.019
response to organic cyclic compound	GO:0014070	89	0.019
posttranscriptional regulation of gene expression	GO:0010608	145	0.019
negative regulation of response to stimulus	GO:0048585	258	0.019
developmental maturation	GO:0021700	172	0.019
regulation of neuron differentiation	GO:0045664	103	0.019
regulation of developmental growth	GO:0048638	174	0.018
memory	GO:0007613	94	0.018
meiotic cell cycle	GO:0051321	171	0.018
secretion	GO:0046903	109	0.018
chemotaxis	GO:0006935	249	0.018
photoreceptor cell development	GO:0042461	96	0.018
rna processing	GO:0006396	147	0.018
regulation of cellular localization	GO:0060341	136	0.018
carboxylic acid metabolic process	GO:0019752	92	0.018
response to bacterium	GO:0009617	198	0.018
response to oxygen levels	GO:0070482	59	0.018	Rat
cell recognition	GO:0008037	102	0.018
regulation of protein metabolic process	GO:0051246	256	0.018
kidney development	GO:0001822	3	0.018
regulation of alternative mrna splicing via spliceosome	GO:0000381	60	0.018
compound eye photoreceptor development	GO:0042051	78	0.017
body morphogenesis	GO:0010171	2	0.017
negative regulation of gene expression	GO:0010629	387	0.017
negative regulation of cellular protein metabolic process	GO:0032269	85	0.017
oocyte construction	GO:0007308	112	0.017
appendage development	GO:0048736	401	0.017
programmed cell death	GO:0012501	257	0.017
response to nutrient levels	GO:0031667	114	0.017
axis specification	GO:0009798	167	0.017
synaptic growth at neuromuscular junction	GO:0051124	119	0.016
positive regulation of gene expression	GO:0010628	290	0.016
cellular response to external stimulus	GO:0071496	66	0.016
appendage morphogenesis	GO:0035107	397	0.016
negative regulation of signaling	GO:0023057	219	0.016
carbohydrate derivative metabolic process	GO:1901135	217	0.015
regulation of cell differentiation	GO:0045595	302	0.015
positive regulation of cell communication	GO:0010647	250	0.015
antimicrobial humoral response	GO:0019730	99	0.015
skeletal muscle organ development	GO:0060538	48	0.015
hindbrain development	GO:0030902	2	0.015
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.015
intracellular transport	GO:0046907	228	0.015
regulation of mrna metabolic process	GO:1903311	72	0.015
regulation of phosphate metabolic process	GO:0019220	210	0.015
cellular response to decreased oxygen levels	GO:0036294	30	0.015
camera type eye development	GO:0043010	4	0.015
cellular response to starvation	GO:0009267	61	0.015
segmentation	GO:0035282	207	0.014
secretion by cell	GO:0032940	101	0.014
multi multicellular organism process	GO:0044706	123	0.014
cell maturation	GO:0048469	144	0.014
regulation of neuron projection development	GO:0010975	69	0.014
regulation of secretion by cell	GO:1903530	39	0.014
regulation of cellular amino acid metabolic process	GO:0006521	0	0.014
organic acid metabolic process	GO:0006082	103	0.014
response to ethanol	GO:0045471	59	0.014
tube development	GO:0035295	244	0.014
organic substance catabolic process	GO:1901575	308	0.014
compound eye photoreceptor cell differentiation	GO:0001751	140	0.014
neurotransmitter secretion	GO:0007269	35	0.014
phosphorylation	GO:0016310	294	0.014
multicellular organismal signaling	GO:0035637	12	0.014	Human
cellular protein modification process	GO:0006464	438	0.014
transmission of nerve impulse	GO:0019226	12	0.014
negative regulation of rna biosynthetic process	GO:1902679	240	0.013
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.013
negative regulation of notch signaling pathway	GO:0045746	41	0.013
positive regulation of rna metabolic process	GO:0051254	271	0.013
cell death	GO:0008219	279	0.013
regulation of mitotic cell cycle	GO:0007346	190	0.013	Rat
regulation of cellular ketone metabolic process	GO:0010565	3	0.013
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.013
muscle system process	GO:0003012	21	0.013
taxis	GO:0042330	304	0.013
negative regulation of insulin secretion	GO:0046676	1	0.013
embryonic development via the syncytial blastoderm	GO:0001700	148	0.013
positive regulation of exocytosis	GO:0045921	4	0.013
carbohydrate derivative biosynthetic process	GO:1901137	85	0.013
organonitrogen compound biosynthetic process	GO:1901566	117	0.013
regulation of growth	GO:0040008	233	0.013
microtubule organizing center organization	GO:0031023	168	0.013
negative regulation of rna metabolic process	GO:0051253	251	0.013
cell division	GO:0051301	248	0.013
chemosensory behavior	GO:0007635	106	0.013
intracellular signal transduction	GO:0035556	300	0.013
regulation of mrna processing	GO:0050684	71	0.012
regulation of catalytic activity	GO:0050790	185	0.012
chemical homeostasis	GO:0048878	92	0.012	Rat
embryo development ending in birth or egg hatching	GO:0009792	152	0.012
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.012
regulation of cellular amine metabolic process	GO:0033238	3	0.012
negative regulation of signal transduction	GO:0009968	206	0.012
regulation of cellular component size	GO:0032535	98	0.012
regulation of transmembrane transport	GO:0034762	27	0.012
catabolic process	GO:0009056	409	0.012
amine metabolic process	GO:0009308	12	0.012
calcium ion transport	GO:0006816	24	0.012
embryonic pattern specification	GO:0009880	174	0.012
muscle fiber development	GO:0048747	12	0.012
response to organophosphorus	GO:0046683	2	0.012
spinal cord development	GO:0021510	1	0.012
mitotic nuclear division	GO:0007067	213	0.012
positive regulation of signaling	GO:0023056	243	0.012
tripartite regional subdivision	GO:0007351	103	0.012
head development	GO:0060322	135	0.012
neuron neuron synaptic transmission	GO:0007270	14	0.012
oocyte axis specification	GO:0007309	108	0.012
mrna splicing via spliceosome	GO:0000398	73	0.012
growth	GO:0040007	359	0.012
regulation of cellular protein metabolic process	GO:0032268	243	0.012
cellular amino acid metabolic process	GO:0006520	61	0.012
sensory perception	GO:0007600	196	0.012
regulation of response to stress	GO:0080134	200	0.012
cellular response to carbohydrate stimulus	GO:0071322	4	0.011
cytokinesis	GO:0000910	90	0.011
purine containing compound metabolic process	GO:0072521	155	0.011
anterior posterior axis specification	GO:0009948	109	0.011
molting cycle process	GO:0022404	29	0.011
regionalization	GO:0003002	416	0.011
g protein coupled receptor signaling pathway	GO:0007186	136	0.011
post embryonic appendage morphogenesis	GO:0035120	385	0.011
retina development in camera type eye	GO:0060041	4	0.011
notch signaling pathway	GO:0007219	120	0.011
potassium ion transmembrane transport	GO:0071805	18	0.011	Human Mouse Rat Fly
positive regulation of molecular function	GO:0044093	136	0.011
synaptic transmission cholinergic	GO:0007271	9	0.011
organic cyclic compound catabolic process	GO:1901361	168	0.011
multicellular organism growth	GO:0035264	46	0.011
regulation of synapse assembly	GO:0051963	94	0.011
erbb signaling pathway	GO:0038127	58	0.011
synaptic vesicle localization	GO:0097479	53	0.011
sodium ion transport	GO:0006814	22	0.011
response to wounding	GO:0009611	94	0.011
ribose phosphate metabolic process	GO:0019693	145	0.011
negative regulation of homeostatic process	GO:0032845	2	0.011
rna splicing via transesterification reactions	GO:0000375	73	0.011
regulation of antimicrobial peptide biosynthetic process	GO:0002805	38	0.011
mitotic cytokinesis	GO:0000281	50	0.011
olfactory behavior	GO:0042048	97	0.011
multi organism behavior	GO:0051705	175	0.011
negative regulation of cellular biosynthetic process	GO:0031327	277	0.011
wing disc morphogenesis	GO:0007472	344	0.011
gravitaxis	GO:0042332	26	0.011
single organism catabolic process	GO:0044712	228	0.011
macromolecule catabolic process	GO:0009057	161	0.010
nucleoside phosphate metabolic process	GO:0006753	162	0.010
mrna metabolic process	GO:0016071	124	0.010
imaginal disc derived wing margin morphogenesis	GO:0008587	41	0.010
establishment of vesicle localization	GO:0051650	51	0.010
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.010
response to radiation	GO:0009314	155	0.010
asymmetric stem cell division	GO:0098722	49	0.010
rna localization	GO:0006403	115	0.010
sensory perception of smell	GO:0007608	80	0.010
cellular ketone metabolic process	GO:0042180	24	0.010
regulation of cell cycle process	GO:0010564	181	0.010	Rat
inositol lipid mediated signaling	GO:0048017	4	0.010

Sh disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of anatomical entity	DOID:7	0.024	Human
nervous system disease	DOID:863	0.013	Human
disease of metabolism	DOID:0014667	0.011
acquired metabolic disease	DOID:0060158	0.011

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network