IMP: Integrative Multi-species Prediction

Drosophila melanogaster

66 known processes

Uba2 (Dmel_CG7528)

Smt3 activating enzyme 2

(Aliases: sip2,uba2,CG7528,DmSAE2,Sae2,Ubc2,DmUba2,dUba2,L36,SAE2,UBA2,DmSae2,Dmuba2,Dmel\CG7528)

Entrez: 44496
FLYBASE: FBgn0029113
UniProtKB: Q7KUA4

Process Predictions
Disease Predictions

Uba2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
negative regulation of cellular metabolic process	GO:0031324	382	0.938
negative regulation of transcription dna templated	GO:0045892	237	0.850
establishment of localization in cell	GO:0051649	402	0.675
negative regulation of biosynthetic process	GO:0009890	277	0.597
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.489
chromosome organization	GO:0051276	360	0.405
cell proliferation	GO:0008283	299	0.343
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.335
regulation of phosphate metabolic process	GO:0019220	210	0.331
cellular protein modification process	GO:0006464	438	0.323
ecdysone mediated induction of salivary gland cell autophagic cell death	GO:0035072	12	0.305
endocytosis	GO:0006897	310	0.290
programmed cell death	GO:0012501	257	0.281
induction of programmed cell death by ecdysone	GO:0035078	12	0.275
induction of programmed cell death	GO:0012502	12	0.253
eye development	GO:0001654	323	0.252
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.242
negative regulation of cellular biosynthetic process	GO:0031327	277	0.240
negative regulation of response to stimulus	GO:0048585	258	0.224
eye morphogenesis	GO:0048592	260	0.222
induction of programmed cell death by hormones	GO:0035081	12	0.215
regulation of apoptotic process	GO:0042981	130	0.206
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.189
negative regulation of catalytic activity	GO:0043086	42	0.173
regulation of response to stress	GO:0080134	200	0.173
retina morphogenesis in camera type eye	GO:0060042	2	0.160
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.159
nucleobase containing small molecule metabolic process	GO:0055086	174	0.154
negative regulation of cellular protein metabolic process	GO:0032269	85	0.149
organic substance catabolic process	GO:1901575	308	0.145
intracellular transport	GO:0046907	228	0.142
regulation of catalytic activity	GO:0050790	185	0.131
negative regulation of gene expression	GO:0010629	387	0.124
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.123
positive regulation of response to stimulus	GO:0048584	323	0.116
glycosyl compound catabolic process	GO:1901658	112	0.109
nucleoside phosphate catabolic process	GO:1901292	110	0.104
regulation of catabolic process	GO:0009894	170	0.101
cellular response to dna damage stimulus	GO:0006974	223	0.101
regulation of cell proliferation	GO:0042127	163	0.099
nucleotide metabolic process	GO:0009117	161	0.098
death	GO:0016265	284	0.094
peptidyl amino acid modification	GO:0018193	105	0.092
tube morphogenesis	GO:0035239	191	0.091
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.089
regulation of cell death	GO:0010941	173	0.088
immune response	GO:0006955	246	0.083
cell cycle phase transition	GO:0044770	140	0.081
regulation of gene expression epigenetic	GO:0040029	128	0.075
purine ribonucleoside catabolic process	GO:0046130	112	0.074
mitotic sister chromatid cohesion	GO:0007064	6	0.074
immune system process	GO:0002376	347	0.073
protein modification process	GO:0036211	438	0.071
regulation of hydrolase activity	GO:0051336	97	0.070
regulation of erbb signaling pathway	GO:1901184	42	0.070
stem cell differentiation	GO:0048863	117	0.069
positive regulation of biosynthetic process	GO:0009891	316	0.067
small molecule metabolic process	GO:0044281	305	0.067
proteolysis	GO:0006508	192	0.067
negative regulation of signal transduction	GO:0009968	206	0.067
negative regulation of rna biosynthetic process	GO:1902679	240	0.067
chromatin organization	GO:0006325	207	0.065
positive regulation of cysteine type endopeptidase activity	GO:2001056	24	0.065
compound eye development	GO:0048749	307	0.064
single organism catabolic process	GO:0044712	228	0.064
regulation of programmed cell death	GO:0043067	152	0.064
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.064
regulation of molecular function	GO:0065009	217	0.063
cell death	GO:0008219	279	0.062
camera type eye morphogenesis	GO:0048593	2	0.061
chromatin modification	GO:0016568	147	0.061
innate immune response	GO:0045087	144	0.060
purine ribonucleotide metabolic process	GO:0009150	145	0.059
vesicle mediated transport	GO:0016192	381	0.057
sister chromatid segregation	GO:0000819	92	0.055
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.053
regulation of cellular catabolic process	GO:0031329	157	0.052
regulation of phosphorylation	GO:0042325	147	0.050
nucleoside triphosphate metabolic process	GO:0009141	120	0.048
response to bacterium	GO:0009617	198	0.048
compound eye morphogenesis	GO:0001745	249	0.047
negative regulation of cell death	GO:0060548	81	0.047
phosphorylation	GO:0016310	294	0.046
regulation of phosphorus metabolic process	GO:0051174	210	0.046
negative regulation of signaling	GO:0023057	219	0.046
organelle assembly	GO:0070925	198	0.045
nucleoside catabolic process	GO:0009164	112	0.044
regulation of cell cycle phase transition	GO:1901987	130	0.044
nucleoside triphosphate catabolic process	GO:0009143	108	0.043
organonitrogen compound metabolic process	GO:1901564	318	0.042
single organism nuclear import	GO:1902593	51	0.041
negative regulation of protein metabolic process	GO:0051248	85	0.041
larval development	GO:0002164	104	0.041
defense response to other organism	GO:0098542	225	0.041
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.039
regulation of dna metabolic process	GO:0051052	34	0.039
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.038
germ line cyst formation	GO:0048134	44	0.038
negative regulation of cell development	GO:0010721	62	0.038
phagocytosis	GO:0006909	215	0.036
retinal cone cell differentiation	GO:0042670	2	0.035
negative regulation of rna metabolic process	GO:0051253	251	0.035
zymogen activation	GO:0031638	20	0.034
neuron apoptotic process	GO:0051402	17	0.034
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.034
aging	GO:0007568	143	0.033
positive regulation of transcription dna templated	GO:0045893	266	0.033
protein phosphorylation	GO:0006468	169	0.033
activation of cysteine type endopeptidase activity involved in apoptotic process	GO:0006919	16	0.033
cell cycle checkpoint	GO:0000075	95	0.032
regulation of cell cycle process	GO:0010564	181	0.032
negative regulation of molecular function	GO:0044092	51	0.032
ribonucleotide metabolic process	GO:0009259	145	0.031
response to alcohol	GO:0097305	95	0.031
nucleotide catabolic process	GO:0009166	109	0.031
protein processing	GO:0016485	68	0.030
carbohydrate derivative catabolic process	GO:1901136	118	0.030
response to external biotic stimulus	GO:0043207	293	0.030
regulation of meiosis	GO:0040020	3	0.030
regulation of protein metabolic process	GO:0051246	256	0.030
translation	GO:0006412	69	0.030
catabolic process	GO:0009056	409	0.030
regulation of mitotic sister chromatid segregation	GO:0033047	28	0.029
negative regulation of phosphorylation	GO:0042326	35	0.029
carbohydrate derivative metabolic process	GO:1901135	217	0.028
purine ribonucleoside metabolic process	GO:0046128	127	0.028
female germ line cyst formation	GO:0048135	42	0.028
dna metabolic process	GO:0006259	227	0.028
negative regulation of cell cycle phase transition	GO:1901988	103	0.028
germarium derived female germ line cyst formation	GO:0030727	42	0.027
ribose phosphate metabolic process	GO:0019693	145	0.027
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	23	0.027
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.027
nucleoside phosphate metabolic process	GO:0006753	162	0.027
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.025
single organism intracellular transport	GO:1902582	207	0.025
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	GO:0070059	4	0.025
response to temperature stimulus	GO:0009266	106	0.025
positive regulation of defense response to bacterium	GO:1900426	23	0.024
regulation of chromatin modification	GO:1903308	28	0.024
protein maturation	GO:0051604	71	0.024
purine containing compound metabolic process	GO:0072521	155	0.024
ribonucleotide catabolic process	GO:0009261	109	0.024
negative regulation of phosphorus metabolic process	GO:0010563	45	0.024
purine nucleotide metabolic process	GO:0006163	146	0.023
dna replication	GO:0006260	48	0.023
wnt signaling pathway	GO:0016055	98	0.023
purine containing compound catabolic process	GO:0072523	112	0.023
mitotic nuclear division	GO:0007067	213	0.023
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.023
atp metabolic process	GO:0046034	49	0.023
erbb signaling pathway	GO:0038127	58	0.023
mitotic sister chromatid separation	GO:0051306	30	0.022
mrna metabolic process	GO:0016071	124	0.022
regulation of defense response	GO:0031347	102	0.022
nuclear division	GO:0000280	332	0.022
organelle localization	GO:0051640	148	0.022
negative regulation of cell differentiation	GO:0045596	143	0.022
purine nucleoside catabolic process	GO:0006152	112	0.022
purine nucleotide catabolic process	GO:0006195	109	0.022
regulation of cell cycle	GO:0051726	291	0.021
retina development in camera type eye	GO:0060041	4	0.021
neural retina development	GO:0003407	4	0.021
regulation of proteolysis	GO:0030162	87	0.021
homeostatic process	GO:0042592	199	0.021
sensory organ morphogenesis	GO:0090596	260	0.021
regulation of immune response	GO:0050776	118	0.021
negative regulation of apoptotic process	GO:0043066	63	0.021
regulation of mitotic cell cycle	GO:0007346	190	0.020
nucleoside monophosphate metabolic process	GO:0009123	52	0.020
gene silencing	GO:0016458	138	0.020
cell cycle g2 m phase transition	GO:0044839	22	0.020
negative regulation of cell cycle process	GO:0010948	109	0.020
protein localization	GO:0008104	284	0.020
appendage development	GO:0048736	401	0.020
regulation of metaphase anaphase transition of cell cycle	GO:1902099	26	0.019
cellular catabolic process	GO:0044248	372	0.019
regulation of cell differentiation	GO:0045595	302	0.019
positive regulation of cell communication	GO:0010647	250	0.019
positive regulation of gene expression	GO:0010628	290	0.019
negative regulation of programmed cell death	GO:0043069	72	0.019
tissue morphogenesis	GO:0048729	297	0.019
regulation of cell development	GO:0060284	215	0.018
heart development	GO:0007507	82	0.018
ribonucleoside catabolic process	GO:0042454	112	0.018
oxoacid metabolic process	GO:0043436	103	0.018
purine ribonucleotide catabolic process	GO:0009154	109	0.018
positive regulation of nucleotide metabolic process	GO:0045981	55	0.018
regulation of innate immune response	GO:0045088	71	0.018
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	73	0.017
single organism biosynthetic process	GO:0044711	206	0.017
negative regulation of phosphate metabolic process	GO:0045936	45	0.017
apoptotic process	GO:0006915	159	0.017
regulation of autophagy	GO:0010506	62	0.017
mitotic cell cycle phase transition	GO:0044772	138	0.017
positive regulation of signaling	GO:0023056	243	0.017
organophosphate metabolic process	GO:0019637	195	0.017
mitotic sister chromatid segregation	GO:0000070	87	0.017
regulation of cellular protein metabolic process	GO:0032268	243	0.017
negative regulation of cell communication	GO:0010648	223	0.017
regulation of gtp catabolic process	GO:0033124	44	0.017
response to organic substance	GO:0010033	284	0.016
embryonic organ development	GO:0048568	50	0.016
response to starvation	GO:0042594	97	0.016
cell growth	GO:0016049	108	0.015
regulation of sister chromatid segregation	GO:0033045	28	0.015
embryo development ending in birth or egg hatching	GO:0009792	152	0.015
glycosyl compound metabolic process	GO:1901657	127	0.015
metaphase anaphase transition of cell cycle	GO:0044784	28	0.015
negative regulation of cell cycle	GO:0045786	116	0.015
regulation of mitotic sister chromatid separation	GO:0010965	28	0.015
positive regulation of intracellular signal transduction	GO:1902533	116	0.015
reproductive structure development	GO:0048608	74	0.015
transcription from rna polymerase ii promoter	GO:0006366	368	0.015
defense response to gram negative bacterium	GO:0050829	94	0.015
regulation of cell division	GO:0051302	72	0.015
negative regulation of gene expression epigenetic	GO:0045814	77	0.015
rna processing	GO:0006396	147	0.014
defense response to bacterium	GO:0042742	178	0.014
response to extracellular stimulus	GO:0009991	116	0.014
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.014
regulation of multi organism process	GO:0043900	131	0.014
nucleocytoplasmic transport	GO:0006913	72	0.014
negative regulation of protein processing	GO:0010955	31	0.014
response to sterol	GO:0036314	34	0.014
ribonucleoside metabolic process	GO:0009119	127	0.014
gtp catabolic process	GO:0006184	72	0.013
negative regulation of developmental process	GO:0051093	201	0.013
intracellular signal transduction	GO:0035556	300	0.013
endomembrane system organization	GO:0010256	119	0.013
mitotic spindle organization	GO:0007052	220	0.013
metaphase anaphase transition of mitotic cell cycle	GO:0007091	28	0.013
chromatin silencing	GO:0006342	76	0.013
organelle membrane fusion	GO:0090174	16	0.013
positive regulation of protein modification process	GO:0031401	58	0.012
morphogenesis of a branching epithelium	GO:0061138	45	0.012
protein catabolic process	GO:0030163	101	0.012
nucleoside metabolic process	GO:0009116	127	0.012
posttranscriptional gene silencing	GO:0016441	46	0.012
carboxylic acid metabolic process	GO:0019752	92	0.012
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.012
neuron maturation	GO:0042551	31	0.012
response to ecdysone	GO:0035075	34	0.012
anatomical structure homeostasis	GO:0060249	97	0.012
nuclear export	GO:0051168	24	0.012
regulation of immune system process	GO:0002682	176	0.012
positive regulation of signal transduction	GO:0009967	223	0.012
regulation of nucleotide catabolic process	GO:0030811	48	0.011
reproductive system development	GO:0061458	74	0.011
positive regulation of molecular function	GO:0044093	136	0.011
purine nucleoside metabolic process	GO:0042278	127	0.011
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.011
positive regulation of cellular biosynthetic process	GO:0031328	316	0.011
organonitrogen compound catabolic process	GO:1901565	128	0.011
cellular macromolecular complex assembly	GO:0034622	153	0.011
regulation of organelle organization	GO:0033043	196	0.011
negative regulation of endopeptidase activity	GO:0010951	11	0.010
regulation of peptidase activity	GO:0052547	39	0.010
regulation of nucleotide metabolic process	GO:0006140	62	0.010
membrane organization	GO:0061024	112	0.010
negative regulation of proteolysis	GO:0045861	31	0.010
regulation of epidermal growth factor receptor signaling pathway	GO:0042058	42	0.010
positive regulation of catalytic activity	GO:0043085	118	0.010
nucleoside monophosphate catabolic process	GO:0009125	39	0.010
cell junction assembly	GO:0034329	42	0.010
organelle fission	GO:0048285	340	0.010

Uba2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of cellular proliferation	DOID:14566	0	0.011

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