IMP: Integrative Multi-species Prediction

Drosophila melanogaster

180 known processes

usp (Dmel_CG4380)

ultraspiracle

(Aliases: EG:22E5.1,DmUsp,DmUSP,dmUSP,CF1/USP,2C,cf1,Dmel\CG4380,Usp,XR2C,USP,NR2B4,CG4380,l(1)2Cf,l(1)usp,CF1,dUSP,CF1/Usp,Cf1)

Entrez: 31165
FLYBASE: FBgn0003964
UniProtKB: M9PGS2
UniProtKB: P20153

Process Predictions
Disease Predictions

usp biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
cell maturation	GO:0048469	144	0.993
blastoderm segmentation	GO:0007350	159	0.991	Fly
mushroom body development	GO:0016319	70	0.986
axis specification	GO:0009798	167	0.979	Fly
eye morphogenesis	GO:0048592	260	0.970
epithelium migration	GO:0090132	148	0.964
oocyte construction	GO:0007308	112	0.963
epithelial cell differentiation	GO:0030855	322	0.957
developmental maturation	GO:0021700	172	0.955
oocyte development	GO:0048599	124	0.953
localization of cell	GO:0051674	257	0.951
embryonic pattern specification	GO:0009880	174	0.948	Fly
response to abiotic stimulus	GO:0009628	341	0.946
tissue morphogenesis	GO:0048729	297	0.925
cell motility	GO:0048870	251	0.903
ovarian follicle cell migration	GO:0007297	121	0.897
border follicle cell migration	GO:0007298	113	0.888
digestive tract morphogenesis	GO:0048546	127	0.883
photoreceptor cell differentiation	GO:0046530	170	0.880
epithelial cell development	GO:0002064	274	0.876
oocyte differentiation	GO:0009994	145	0.854
stem cell division	GO:0017145	69	0.851	Fly
ameboidal type cell migration	GO:0001667	151	0.845
oocyte axis specification	GO:0007309	108	0.840
regulation of actin filament based process	GO:0032970	42	0.826
tube morphogenesis	GO:0035239	191	0.799
epithelial cell migration	GO:0010631	148	0.793
response to sterol	GO:0036314	34	0.792
muscle structure development	GO:0061061	224	0.782
regulation of actin cytoskeleton organization	GO:0032956	42	0.781
negative regulation of developmental process	GO:0051093	201	0.773
response to wounding	GO:0009611	94	0.771	Fly
locomotory behavior	GO:0007626	176	0.767	Fly
single organism cellular localization	GO:1902580	180	0.763
eye development	GO:0001654	323	0.762
eye photoreceptor cell differentiation	GO:0001754	145	0.748
cell migration	GO:0016477	238	0.742
cell adhesion	GO:0007155	136	0.735
regulation of apoptotic process	GO:0042981	130	0.724
sensory organ morphogenesis	GO:0090596	260	0.715
compound eye photoreceptor cell differentiation	GO:0001751	140	0.715
cellular ketone metabolic process	GO:0042180	24	0.705
regulation of cell development	GO:0060284	215	0.702	Fly
positive regulation of cellular amine metabolic process	GO:0033240	0	0.699
cell substrate adhesion	GO:0031589	10	0.698
regulation of cellular localization	GO:0060341	136	0.691
tissue migration	GO:0090130	155	0.677
actomyosin structure organization	GO:0031032	56	0.666
actin filament based process	GO:0030029	220	0.664
negative regulation of cell differentiation	GO:0045596	143	0.656
regulation of anatomical structure morphogenesis	GO:0022603	242	0.648	Fly
nuclear division	GO:0000280	332	0.644
morphogenesis of an epithelium	GO:0002009	276	0.637
stem cell proliferation	GO:0072089	88	0.636	Fly
single organism behavior	GO:0044708	391	0.628	Fly
establishment of localization in cell	GO:0051649	402	0.622	Fly
head development	GO:0060322	135	0.604
cellular macromolecule localization	GO:0070727	220	0.585
nucleotide metabolic process	GO:0009117	161	0.569
photoreceptor cell development	GO:0042461	96	0.565
segmentation	GO:0035282	207	0.561	Fly
digestive system development	GO:0055123	149	0.558
apoptotic process	GO:0006915	159	0.555
programmed cell death	GO:0012501	257	0.545
cellular response to organic cyclic compound	GO:0071407	32	0.537
ion transport	GO:0006811	145	0.536
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.532
muscle cell development	GO:0055001	50	0.515
aging	GO:0007568	143	0.513
multicellular organismal aging	GO:0010259	140	0.502
brain development	GO:0007420	120	0.500
compound eye morphogenesis	GO:0001745	249	0.498
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.478	Fly
striated muscle cell development	GO:0055002	50	0.468
organelle fission	GO:0048285	340	0.468
regulation of actin filament length	GO:0030832	27	0.467
anterior posterior pattern specification	GO:0009952	136	0.466	Fly
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.463	Fly
positive regulation of developmental process	GO:0051094	143	0.456	Fly
regulation of transport	GO:0051049	181	0.441
eye photoreceptor cell development	GO:0042462	81	0.429
camera type eye development	GO:0043010	4	0.427
chemical homeostasis	GO:0048878	92	0.425
regulation of cell adhesion	GO:0030155	27	0.414
intracellular steroid hormone receptor signaling pathway	GO:0030518	12	0.409
immune system process	GO:0002376	347	0.408	Fly
regulation of mitotic cell cycle	GO:0007346	190	0.407
body morphogenesis	GO:0010171	2	0.407
urogenital system development	GO:0001655	72	0.406
purine nucleoside catabolic process	GO:0006152	112	0.400
regulation of programmed cell death	GO:0043067	152	0.397
cell death	GO:0008219	279	0.397
dendrite development	GO:0016358	204	0.397
response to ecdysone	GO:0035075	34	0.396
regulation of actin polymerization or depolymerization	GO:0008064	27	0.392
ribonucleoside metabolic process	GO:0009119	127	0.385
developmental growth	GO:0048589	280	0.381	Fly
actin cytoskeleton organization	GO:0030036	206	0.376
compound eye development	GO:0048749	307	0.372
cellular response to organic substance	GO:0071310	132	0.371
male gamete generation	GO:0048232	201	0.366
growth	GO:0040007	359	0.359	Fly
metal ion transport	GO:0030001	74	0.353
maternal determination of anterior posterior axis embryo	GO:0008358	74	0.349
regionalization	GO:0003002	416	0.348	Fly
single organism intracellular transport	GO:1902582	207	0.346
regulation of cytoskeleton organization	GO:0051493	89	0.338
regulation of cell differentiation	GO:0045595	302	0.337	Fly
dorsal ventral axis specification	GO:0009950	66	0.321
regulation of organelle organization	GO:0033043	196	0.318
open tracheal system development	GO:0007424	204	0.316
regulation of protein transport	GO:0051223	57	0.315
regulation of localization	GO:0032879	275	0.314	Fly
response to endogenous stimulus	GO:0009719	119	0.313
detection of stimulus	GO:0051606	156	0.312
compound eye photoreceptor development	GO:0042051	78	0.304
response to alcohol	GO:0097305	95	0.304
cellular component assembly involved in morphogenesis	GO:0010927	151	0.302
embryonic axis specification	GO:0000578	107	0.298	Fly
oocyte dorsal ventral axis specification	GO:0007310	34	0.295
cellular amine metabolic process	GO:0044106	12	0.283
response to organic cyclic compound	GO:0014070	89	0.280
secretion by cell	GO:0032940	101	0.279	Fly
cellular response to oxygen containing compound	GO:1901701	79	0.279
negative regulation of cell communication	GO:0010648	223	0.275
actin polymerization or depolymerization	GO:0008154	31	0.273
dorsal ventral pattern formation	GO:0009953	133	0.271
renal system development	GO:0072001	72	0.270
wing disc morphogenesis	GO:0007472	344	0.267	Fly
muscle cell differentiation	GO:0042692	103	0.266
embryo development ending in birth or egg hatching	GO:0009792	152	0.261
negative regulation of response to stimulus	GO:0048585	258	0.256
organic acid metabolic process	GO:0006082	103	0.256
cellular response to ketone	GO:1901655	17	0.255
ribose phosphate metabolic process	GO:0019693	145	0.248
intracellular protein transport	GO:0006886	104	0.239
digestive tract development	GO:0048565	149	0.239
ovarian follicle cell development	GO:0030707	248	0.237
lipid metabolic process	GO:0006629	121	0.234
cholesterol homeostasis	GO:0042632	3	0.233
anterior posterior axis specification embryo	GO:0008595	103	0.232	Fly
homeostatic process	GO:0042592	199	0.226
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.217
post embryonic appendage morphogenesis	GO:0035120	385	0.215	Fly
positive regulation of axonogenesis	GO:0050772	2	0.212	Fly
negative regulation of cellular metabolic process	GO:0031324	382	0.209	Fly
vesicle mediated transport	GO:0016192	381	0.204
regulation of cellular amino acid metabolic process	GO:0006521	0	0.204
sterol homeostasis	GO:0055092	4	0.204
response to organonitrogen compound	GO:0010243	75	0.200
neuron maturation	GO:0042551	31	0.194
axonogenesis	GO:0007409	290	0.190	Fly
camera type eye morphogenesis	GO:0048593	2	0.190
negative regulation of signaling	GO:0023057	219	0.186
transforming growth factor beta receptor signaling pathway	GO:0007179	16	0.186
glycosyl compound catabolic process	GO:1901658	112	0.182
stem cell maintenance	GO:0019827	67	0.177
negative regulation of neural precursor cell proliferation	GO:2000178	27	0.177
regulation of cellular protein metabolic process	GO:0032268	243	0.177
small molecule metabolic process	GO:0044281	305	0.177
regulation of hormone levels	GO:0010817	40	0.177
nucleobase containing small molecule metabolic process	GO:0055086	174	0.176
cellular amino acid metabolic process	GO:0006520	61	0.175
negative regulation of programmed cell death	GO:0043069	72	0.174
inter male aggressive behavior	GO:0002121	60	0.171	Fly
establishment of protein localization to plasma membrane	GO:0090002	9	0.170
organonitrogen compound metabolic process	GO:1901564	318	0.168
regulation of cellular amine metabolic process	GO:0033238	3	0.167
regulation of protein localization	GO:0032880	76	0.166
purine containing compound metabolic process	GO:0072521	155	0.161
cell migration involved in gastrulation	GO:0042074	9	0.160
biological adhesion	GO:0022610	138	0.156
regulation of vesicle mediated transport	GO:0060627	59	0.155
positive regulation of multicellular organismal process	GO:0051240	143	0.154	Fly
actin filament polymerization	GO:0030041	27	0.154
nucleoside triphosphate catabolic process	GO:0009143	108	0.152
skeletal muscle organ development	GO:0060538	48	0.149
development of primary sexual characteristics	GO:0045137	50	0.148
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.147
regulation of secretion by cell	GO:1903530	39	0.147
death	GO:0016265	284	0.145
regulation of intracellular protein transport	GO:0033157	46	0.143
carboxylic acid metabolic process	GO:0019752	92	0.143
carbohydrate derivative catabolic process	GO:1901136	118	0.143
gastrulation	GO:0007369	70	0.142
circadian rhythm	GO:0007623	105	0.139	Fly
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.139	Fly
cell division	GO:0051301	248	0.138	Fly
rhabdomere development	GO:0042052	38	0.138
response to lipid	GO:0033993	38	0.135
learning or memory	GO:0007611	141	0.135
positive regulation of programmed cell death	GO:0043068	62	0.133
negative regulation of cellular biosynthetic process	GO:0031327	277	0.132	Fly
protein transport	GO:0015031	155	0.132
actin filament organization	GO:0007015	126	0.130
pupal development	GO:0035209	11	0.127
stem cell differentiation	GO:0048863	117	0.127
regulation of multicellular organismal development	GO:2000026	414	0.125	Fly
cytoplasmic transport	GO:0016482	130	0.124
positive regulation of developmental growth	GO:0048639	62	0.124	Fly
cell type specific apoptotic process	GO:0097285	38	0.123
reproductive structure development	GO:0048608	74	0.121
maintenance of protein location	GO:0045185	28	0.121
glycosyl compound metabolic process	GO:1901657	127	0.121
regulation of cell morphogenesis	GO:0022604	163	0.120	Fly
appendage morphogenesis	GO:0035107	397	0.119	Fly
regulation of phosphorus metabolic process	GO:0051174	210	0.119
gastrulation with mouth forming first	GO:0001703	36	0.118
response to nitrogen compound	GO:1901698	90	0.116
regulation of cell cell adhesion	GO:0022407	21	0.111
regulation of reproductive process	GO:2000241	54	0.108
larval development	GO:0002164	104	0.107
regulation of cellular component biogenesis	GO:0044087	201	0.105
tripartite regional subdivision	GO:0007351	103	0.105	Fly
muscle organ development	GO:0007517	127	0.105
catabolic process	GO:0009056	409	0.104
nucleoside catabolic process	GO:0009164	112	0.104
determination of adult lifespan	GO:0008340	137	0.104
negative regulation of cell adhesion	GO:0007162	9	0.103
multicellular organismal homeostasis	GO:0048871	41	0.102
regulation of cell substrate adhesion	GO:0010810	2	0.101
spermatogenesis	GO:0007283	200	0.101
nucleoside phosphate catabolic process	GO:1901292	110	0.101
sleep	GO:0030431	49	0.100
lipid catabolic process	GO:0016042	21	0.100
intracellular transport	GO:0046907	228	0.099
oxoacid metabolic process	GO:0043436	103	0.099
cation transport	GO:0006812	110	0.098
protein localization to plasma membrane	GO:0072659	13	0.098
cell matrix adhesion	GO:0007160	6	0.096
carbohydrate derivative metabolic process	GO:1901135	217	0.096
regulation of cellular ketone metabolic process	GO:0010565	3	0.095
purine ribonucleotide catabolic process	GO:0009154	109	0.095
dendrite morphogenesis	GO:0048813	199	0.094
negative regulation of signal transduction	GO:0009968	206	0.094
negative regulation of gene expression	GO:0010629	387	0.091	Fly
organic hydroxy compound metabolic process	GO:1901615	83	0.089
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.089	Fly
response to peptide hormone	GO:0043434	29	0.089
convergent extension involved in gastrulation	GO:0060027	2	0.088
negative regulation of apoptotic process	GO:0043066	63	0.088
response to oxygen containing compound	GO:1901700	200	0.088
negative regulation of transcription dna templated	GO:0045892	237	0.087	Fly
regulation of cellular catabolic process	GO:0031329	157	0.087
sex differentiation	GO:0007548	81	0.086
cellular response to endogenous stimulus	GO:0071495	80	0.086
negative regulation of cell death	GO:0060548	81	0.086
reproductive system development	GO:0061458	74	0.085
positive regulation of reactive oxygen species metabolic process	GO:2000379	0	0.085
detection of external stimulus	GO:0009581	66	0.085
gonad development	GO:0008406	50	0.085
oocyte anterior posterior axis specification	GO:0007314	72	0.085
regulation of cellular component movement	GO:0051270	42	0.082	Fly
imaginal disc derived wing morphogenesis	GO:0007476	337	0.082	Fly
oocyte microtubule cytoskeleton organization	GO:0016325	35	0.081
neural precursor cell proliferation	GO:0061351	75	0.081	Fly
kidney morphogenesis	GO:0060993	3	0.080
negative regulation of cell cell adhesion	GO:0022408	8	0.079
cellular homeostasis	GO:0019725	80	0.079
organophosphate metabolic process	GO:0019637	195	0.079
negative regulation of biosynthetic process	GO:0009890	277	0.076	Fly
regulation of cell death	GO:0010941	173	0.075
cytokinesis	GO:0000910	90	0.074
regulation of metal ion transport	GO:0010959	15	0.074
negative regulation of neuroblast proliferation	GO:0007406	27	0.074
protein localization	GO:0008104	284	0.073
multicellular organismal reproductive behavior	GO:0033057	110	0.072
myofibril assembly	GO:0030239	36	0.071
stress fiber assembly	GO:0043149	6	0.071
mitotic spindle organization	GO:0007052	220	0.071
kidney development	GO:0001822	3	0.071
neuron remodeling	GO:0016322	29	0.070
regulation of stem cell proliferation	GO:0072091	40	0.070
negative regulation of rna metabolic process	GO:0051253	251	0.069	Fly
response to hypoxia	GO:0001666	53	0.069
intracellular mrna localization	GO:0008298	66	0.069
cellular catabolic process	GO:0044248	372	0.069
phagocytosis	GO:0006909	215	0.068
cell junction organization	GO:0034330	57	0.068
regulation of cell cycle process	GO:0010564	181	0.068
convergent extension	GO:0060026	2	0.067
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.066	Fly
male mating behavior	GO:0060179	70	0.066
regulation of ion transport	GO:0043269	39	0.066
proteolysis	GO:0006508	192	0.066
positive regulation of cell death	GO:0010942	69	0.066
purine nucleotide catabolic process	GO:0006195	109	0.064
cellular component disassembly	GO:0022411	46	0.064
regulation of actin filament polymerization	GO:0030833	25	0.063
retina development in camera type eye	GO:0060041	4	0.062
establishment of protein localization to membrane	GO:0090150	11	0.062
positive regulation of phosphate metabolic process	GO:0045937	139	0.061
macromolecular complex assembly	GO:0065003	256	0.060
response to decreased oxygen levels	GO:0036293	58	0.060
intracellular mrna localization involved in pattern specification process	GO:0060810	56	0.060
positive regulation of apoptotic process	GO:0043065	47	0.060
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.059	Fly
neurological system process	GO:0050877	358	0.059
cellular chemical homeostasis	GO:0055082	40	0.059
ribonucleotide catabolic process	GO:0009261	109	0.059
response to inorganic substance	GO:0010035	44	0.058
peptidyl amino acid modification	GO:0018193	105	0.058
respiratory system development	GO:0060541	213	0.058
response to ketone	GO:1901654	34	0.058
organic substance transport	GO:0071702	257	0.056
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.056
positive regulation of dendrite morphogenesis	GO:0050775	9	0.055
regulation of secretion	GO:0051046	44	0.054
positive regulation of cell projection organization	GO:0031346	29	0.054	Fly
striated muscle cell differentiation	GO:0051146	90	0.054
purine nucleoside metabolic process	GO:0042278	127	0.053
multi organism reproductive behavior	GO:0044705	121	0.052
regulation of cell cycle	GO:0051726	291	0.052	Fly
taxis	GO:0042330	304	0.052	Fly
germ cell migration	GO:0008354	43	0.052
pole plasm oskar mrna localization	GO:0045451	46	0.051
nucleoside metabolic process	GO:0009116	127	0.051
regulation of neural precursor cell proliferation	GO:2000177	35	0.051
intracellular mrna localization involved in anterior posterior axis specification	GO:0060811	53	0.051
detection of light stimulus	GO:0009583	58	0.051
regulation of intracellular transport	GO:0032386	64	0.050
negative regulation of cellular component organization	GO:0051129	108	0.050
maintenance of protein location in cell	GO:0032507	26	0.050
organic substance catabolic process	GO:1901575	308	0.050
nuclear export	GO:0051168	24	0.049
negative regulation of molecular function	GO:0044092	51	0.049
endocytosis	GO:0006897	310	0.049
organophosphate catabolic process	GO:0046434	112	0.049
positive regulation of cell differentiation	GO:0045597	64	0.048	Fly
positive regulation of secretion	GO:0051047	22	0.048
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.048	Fly
amine metabolic process	GO:0009308	12	0.048
purine nucleotide metabolic process	GO:0006163	146	0.048
humoral immune response	GO:0006959	117	0.048
cognition	GO:0050890	141	0.048
aromatic compound catabolic process	GO:0019439	166	0.048
hindgut development	GO:0061525	58	0.047
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.046
cellular response to nitrogen compound	GO:1901699	51	0.046
nucleoside phosphate metabolic process	GO:0006753	162	0.046
positive regulation of organelle organization	GO:0010638	65	0.045
regulation of cytoplasmic transport	GO:1903649	47	0.045
cell fate determination	GO:0001709	91	0.044
secretion	GO:0046903	109	0.044	Fly
nucleotide catabolic process	GO:0009166	109	0.044
actin filament bundle organization	GO:0061572	28	0.044
nuclear import	GO:0051170	51	0.044
protein complex assembly	GO:0006461	200	0.043
regulation of lipid metabolic process	GO:0019216	15	0.043
regulation of embryonic development	GO:0045995	68	0.043
maintenance of location	GO:0051235	73	0.042
purine ribonucleoside metabolic process	GO:0046128	127	0.042
negative regulation of cell development	GO:0010721	62	0.042
regulation of establishment of protein localization to plasma membrane	GO:0090003	7	0.042
nuclear transport	GO:0051169	72	0.042
mitotic nuclear division	GO:0007067	213	0.042
cellular macromolecular complex assembly	GO:0034622	153	0.042
circadian behavior	GO:0048512	76	0.041	Fly
regulation of axon extension	GO:0030516	8	0.041	Fly
nitrogen compound transport	GO:0071705	85	0.040
regulation of cell matrix adhesion	GO:0001952	1	0.040
positive regulation of cellular biosynthetic process	GO:0031328	316	0.040
receptor mediated endocytosis	GO:0006898	21	0.040
cellular response to chemical stimulus	GO:0070887	199	0.040
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090100	9	0.040
protein localization to organelle	GO:0033365	82	0.040
collateral sprouting	GO:0048668	3	0.039
muscle tissue development	GO:0060537	30	0.039
phosphatidylinositol mediated signaling	GO:0048015	4	0.039
regulation of immune system process	GO:0002682	176	0.039	Fly
regulation of nervous system development	GO:0051960	248	0.039	Fly
single organism catabolic process	GO:0044712	228	0.039
response to organic substance	GO:0010033	284	0.039
response to monosaccharide	GO:0034284	4	0.039
regulation of lamellipodium organization	GO:1902743	15	0.038
actin filament based movement	GO:0030048	26	0.038
regulation of locomotion	GO:0040012	42	0.038	Fly
regulation of cellular component size	GO:0032535	98	0.037	Fly
regulation of response to external stimulus	GO:0032101	115	0.037	Fly
heterocycle catabolic process	GO:0046700	166	0.037
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.037
cytoplasm organization	GO:0007028	64	0.037
positive regulation of secretion by cell	GO:1903532	20	0.037
regulation of hydrolase activity	GO:0051336	97	0.036
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.036
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.035
ion homeostasis	GO:0050801	55	0.035
cellular response to dna damage stimulus	GO:0006974	223	0.035
cellular response to peptide	GO:1901653	28	0.035
regulation of protein depolymerization	GO:1901879	27	0.034
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.034
purine ribonucleotide metabolic process	GO:0009150	145	0.033
steroid metabolic process	GO:0008202	20	0.033
regulation of synaptic plasticity	GO:0048167	14	0.033
intracellular receptor signaling pathway	GO:0030522	19	0.033
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.033
organic cyclic compound catabolic process	GO:1901361	168	0.033
negative regulation of sequestering of calcium ion	GO:0051283	2	0.033
response to nutrient levels	GO:0031667	114	0.033
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.032
regulation of nucleocytoplasmic transport	GO:0046822	35	0.032
regulation of developmental growth	GO:0048638	174	0.032	Fly
response to temperature stimulus	GO:0009266	106	0.032
response to oxygen levels	GO:0070482	59	0.032
ecdysone receptor mediated signaling pathway	GO:0035076	11	0.032
extrinsic apoptotic signaling pathway	GO:0097191	1	0.032
positive regulation of cell migration	GO:0030335	2	0.032
antimicrobial humoral response	GO:0019730	99	0.031
anterior posterior axis specification	GO:0009948	109	0.031	Fly
positive regulation of protein transport	GO:0051222	37	0.031
rhythmic process	GO:0048511	106	0.031	Fly
cellular response to abiotic stimulus	GO:0071214	58	0.031
cellular protein complex assembly	GO:0043623	71	0.031
regulation of cell shape	GO:0008360	113	0.030
organonitrogen compound catabolic process	GO:1901565	128	0.030
connective tissue development	GO:0061448	3	0.030
pole plasm assembly	GO:0007315	61	0.030
larval behavior	GO:0030537	42	0.030
response to radiation	GO:0009314	155	0.030
regulation of cell motility	GO:2000145	23	0.030
regulation of hemocyte proliferation	GO:0035206	37	0.030	Fly
positive regulation of phosphorus metabolic process	GO:0010562	139	0.030
regulation of anatomical structure size	GO:0090066	163	0.029	Fly
organelle assembly	GO:0070925	198	0.029
regulation of dna binding	GO:0051101	10	0.029
establishment of protein localization	GO:0045184	163	0.029
actin filament depolymerization	GO:0030042	5	0.029
cellular response to ecdysone	GO:0071390	17	0.028
regulation of cell division	GO:0051302	72	0.028
positive regulation of macromolecule metabolic process	GO:0010604	405	0.028
mating	GO:0007618	120	0.028
regulation of circadian rhythm	GO:0042752	49	0.028
protein targeting	GO:0006605	64	0.028
regulation of catalytic activity	GO:0050790	185	0.028
negative regulation of rna biosynthetic process	GO:1902679	240	0.028	Fly
regulation of protein localization to plasma membrane	GO:1903076	7	0.027
guanosine containing compound catabolic process	GO:1901069	74	0.027
positive regulation of cell motility	GO:2000147	3	0.027
tissue homeostasis	GO:0001894	36	0.027
rho protein signal transduction	GO:0007266	14	0.027
plasma membrane organization	GO:0007009	26	0.027
carbohydrate metabolic process	GO:0005975	82	0.027
response to virus	GO:0009615	28	0.026
gtp catabolic process	GO:0006184	72	0.026
dna integrity checkpoint	GO:0031570	81	0.026
regulation of purine nucleotide metabolic process	GO:1900542	62	0.026
apoptotic signaling pathway	GO:0097190	27	0.026
regulation of molecular function	GO:0065009	217	0.026
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.026
stem cell development	GO:0048864	79	0.025
ribonucleotide metabolic process	GO:0009259	145	0.025
regulation of establishment of protein localization	GO:0070201	61	0.025
ribonucleoside catabolic process	GO:0042454	112	0.025
regulation of behavior	GO:0050795	75	0.025	Fly
morphogenesis of a polarized epithelium	GO:0001738	93	0.025
salivary gland development	GO:0007431	162	0.025
regulation of peptide hormone secretion	GO:0090276	5	0.025
positive regulation of rna biosynthetic process	GO:1902680	266	0.025
negative regulation of cellular protein metabolic process	GO:0032269	85	0.025
synaptic transmission	GO:0007268	288	0.024
positive regulation of response to stimulus	GO:0048584	323	0.024	Fly
regulation of blood circulation	GO:1903522	21	0.024
single organism carbohydrate metabolic process	GO:0044723	72	0.024
purine ribonucleoside catabolic process	GO:0046130	112	0.024
positive regulation of signaling	GO:0023056	243	0.024
central nervous system development	GO:0007417	201	0.024
single organism membrane organization	GO:0044802	93	0.024
regulation of proteolysis	GO:0030162	87	0.023
phosphorylation	GO:0016310	294	0.023
neuroblast proliferation	GO:0007405	74	0.023	Fly
regulation of neuroblast proliferation	GO:1902692	34	0.023
nucleobase containing compound catabolic process	GO:0034655	165	0.023
immune system development	GO:0002520	57	0.022
retina morphogenesis in camera type eye	GO:0060042	2	0.022
olfactory behavior	GO:0042048	97	0.022
cellular protein localization	GO:0034613	160	0.022
nucleocytoplasmic transport	GO:0006913	72	0.022
regulation of actin filament depolymerization	GO:0030834	3	0.022
nucleoside monophosphate catabolic process	GO:0009125	39	0.022
developmental programmed cell death	GO:0010623	138	0.021
exocrine system development	GO:0035272	162	0.021
macromolecule catabolic process	GO:0009057	161	0.021
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.021
regulation of synaptic transmission	GO:0050804	69	0.021
maintenance of location in cell	GO:0051651	28	0.021
negative regulation of peptide secretion	GO:0002792	1	0.021
axon guidance	GO:0007411	233	0.021	Fly
rhythmic behavior	GO:0007622	76	0.021	Fly
regulation of protein metabolic process	GO:0051246	256	0.021
intrinsic apoptotic signaling pathway in response to dna damage	GO:0008630	11	0.020
gland morphogenesis	GO:0022612	145	0.020
lipid localization	GO:0010876	54	0.020
columnar cuboidal epithelial cell development	GO:0002066	249	0.020
atp metabolic process	GO:0046034	49	0.020
golgi to plasma membrane transport	GO:0006893	8	0.020
positive regulation of transport	GO:0051050	92	0.020
mitotic cell cycle phase transition	GO:0044772	138	0.019

usp disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.031
	nervous system disease	DOID:863	0	0.020

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