IMP: Integrative Multi-species Prediction

Drosophila melanogaster

47 known processes

rst (Dmel_CG4125)

roughest

(Aliases: Irre-C,irreC,irrecC-rst,irreC-rst,IrreC-Rst,Dmel\CG4125,IRREC/RST,IrreC/Rst,UB883,CG4125,rst/irrecC,IrrecC,IREE-C,rst-irrecC,Rst,IrreC-rst,CT13684,IrreC,rst-irreC)

FLYBASE: FBgn0003285
Entrez: 31290
UniProtKB: X2JCF8
UniProtKB: Q08180

Process Predictions
Disease Predictions

rst biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
myoblast fusion	GO:0007520	43	0.999	Fly
syncytium formation by plasma membrane fusion	GO:0000768	43	0.998	Fly
muscle cell differentiation	GO:0042692	103	0.983	Fly
striated muscle cell differentiation	GO:0051146	90	0.980	Fly
brain development	GO:0007420	120	0.968	Mouse Fly
eye development	GO:0001654	323	0.965
eye morphogenesis	GO:0048592	260	0.964
syncytium formation	GO:0006949	43	0.950	Fly
muscle structure development	GO:0061061	224	0.946
regulation of anatomical structure morphogenesis	GO:0022603	242	0.913	Fly
actin filament based process	GO:0030029	220	0.906	Mouse Fly
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.897
nephrocyte diaphragm assembly	GO:0036059	3	0.879	Fly
establishment of tissue polarity	GO:0007164	87	0.876	Fly
ommatidial rotation	GO:0016318	20	0.871
head development	GO:0060322	135	0.862	Mouse Fly
extracellular structure organization	GO:0043062	46	0.859	Zebrafish
negative regulation of signal transduction	GO:0009968	206	0.857	Fly
tube morphogenesis	GO:0035239	191	0.836	Fly
renal tubule development	GO:0061326	64	0.831	Fly
positive regulation of endopeptidase activity	GO:0010950	26	0.826	Fly
regulation of organ growth	GO:0046620	42	0.820	Fly
regulation of multicellular organismal development	GO:2000026	414	0.814
myotube differentiation	GO:0014902	46	0.804	Fly
respiratory system development	GO:0060541	213	0.803	Fly
establishment of planar polarity	GO:0001736	87	0.787	Fly
branching morphogenesis of an epithelial tube	GO:0048754	45	0.787	Fly
regulation of cell differentiation	GO:0045595	302	0.781	Fly
kidney development	GO:0001822	3	0.759	Zebrafish Mouse
central nervous system development	GO:0007417	201	0.743	Mouse Fly
nephron development	GO:0072006	3	0.722	Zebrafish Mouse
negative regulation of cell communication	GO:0010648	223	0.713	Fly
positive regulation of peptidase activity	GO:0010952	29	0.713	Fly
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.713	Fly
eye photoreceptor cell differentiation	GO:0001754	145	0.702	Fly
compound eye development	GO:0048749	307	0.699
morphogenesis of a polarized epithelium	GO:0001738	93	0.679	Fly
cellular component assembly involved in morphogenesis	GO:0010927	151	0.672	Fly
morphogenesis of a branching epithelium	GO:0061138	45	0.665	Fly
actin filament bundle assembly	GO:0051017	26	0.656	Fly
actin filament organization	GO:0007015	126	0.651	Mouse Fly
segmentation	GO:0035282	207	0.636
filtration diaphragm assembly	GO:0036058	4	0.635	Fly
adherens junction assembly	GO:0034333	11	0.633	Fly
fusion cell fate specification	GO:0035156	4	0.622	Fly
regulation of organ morphogenesis	GO:2000027	78	0.614
regulation of neuron differentiation	GO:0045664	103	0.606
morphogenesis of an epithelium	GO:0002009	276	0.573	Fly
epithelial tube morphogenesis	GO:0060562	88	0.561	Fly
eggshell formation	GO:0030703	105	0.554	Fly
regulation of endopeptidase activity	GO:0052548	36	0.552	Fly
regulation of cell development	GO:0060284	215	0.551	Fly
axonogenesis	GO:0007409	290	0.550
open tracheal system development	GO:0007424	204	0.540	Fly
tissue morphogenesis	GO:0048729	297	0.537	Fly
skeletal muscle fiber development	GO:0048741	3	0.536
somatic muscle development	GO:0007525	66	0.531
post embryonic appendage morphogenesis	GO:0035120	385	0.526	Fly
compound eye morphogenesis	GO:0001745	249	0.519
regulation of programmed cell death	GO:0043067	152	0.514
adult chitin based cuticle development	GO:0008365	2	0.498	Fly
gland development	GO:0048732	191	0.493
regulation of nervous system development	GO:0051960	248	0.482	Fly
adult chitin based cuticle pattern formation	GO:0035018	1	0.475	Fly
positive regulation of signaling	GO:0023056	243	0.471	Fly
imaginal disc derived appendage development	GO:0048737	399	0.463	Fly
negative regulation of response to stimulus	GO:0048585	258	0.462	Fly
positive regulation of rna metabolic process	GO:0051254	271	0.462
cellular macromolecule localization	GO:0070727	220	0.459
cell adhesion	GO:0007155	136	0.458
compound eye photoreceptor cell differentiation	GO:0001751	140	0.453	Fly
axon guidance	GO:0007411	233	0.443
cell cell adhesion via plasma membrane adhesion molecules	GO:0098742	26	0.439
establishment of ommatidial planar polarity	GO:0042067	49	0.431	Fly
appendage morphogenesis	GO:0035107	397	0.429	Fly
protein localization	GO:0008104	284	0.428
myotube cell development	GO:0014904	3	0.427
regulation of phosphorylation	GO:0042325	147	0.416	Mouse
sensory organ morphogenesis	GO:0090596	260	0.413
regulation of anatomical structure size	GO:0090066	163	0.406	Mouse
regulation of cell fate specification	GO:0042659	27	0.406	Fly
regulation of cell morphogenesis	GO:0022604	163	0.402	Fly
positive regulation of cell development	GO:0010720	61	0.401
muscle organ development	GO:0007517	127	0.396
cellular protein localization	GO:0034613	160	0.391
ovarian follicle cell development	GO:0030707	248	0.390	Fly
neuron projection guidance	GO:0097485	241	0.389
photoreceptor cell differentiation	GO:0046530	170	0.389	Fly
immune response	GO:0006955	246	0.383
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.383
homophilic cell adhesion via plasma membrane adhesion molecules	GO:0007156	18	0.376
regulation of myoblast fusion	GO:1901739	6	0.375	Fly
stem cell proliferation	GO:0072089	88	0.373
actin cytoskeleton organization	GO:0030036	206	0.370	Mouse Fly
proteolysis	GO:0006508	192	0.367	Fly
oocyte differentiation	GO:0009994	145	0.352
dorsal closure	GO:0007391	79	0.348	Fly
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.343
growth	GO:0040007	359	0.332	Fly
single organism cell adhesion	GO:0098602	47	0.330	Mouse Fly
single organismal cell cell adhesion	GO:0016337	45	0.323	Mouse Fly
notch receptor processing	GO:0007220	13	0.320	Fly
actin filament bundle organization	GO:0061572	28	0.320	Fly
protein modification by small protein conjugation	GO:0032446	79	0.317
negative regulation of multicellular organismal process	GO:0051241	142	0.295	Fly
morphogenesis of embryonic epithelium	GO:0016331	94	0.289	Fly
regulation of protein metabolic process	GO:0051246	256	0.285	Mouse Fly
lateral inhibition	GO:0046331	206	0.284
kidney epithelium development	GO:0072073	3	0.282	Zebrafish
transcription from rna polymerase ii promoter	GO:0006366	368	0.272
regulation of neurogenesis	GO:0050767	158	0.264	Fly
negative regulation of cellular metabolic process	GO:0031324	382	0.263	Mouse
regulation of cellular component size	GO:0032535	98	0.254	Mouse
axon development	GO:0061564	297	0.254
taxis	GO:0042330	304	0.254
regulation of immune system process	GO:0002682	176	0.253
chorion containing eggshell formation	GO:0007304	105	0.251	Fly
urogenital system development	GO:0001655	72	0.248	Zebrafish Mouse Fly
positive regulation of macromolecule metabolic process	GO:0010604	405	0.246	Fly
cell fate specification	GO:0001708	71	0.246	Fly
regulation of neuron projection development	GO:0010975	69	0.245
protein modification by small protein conjugation or removal	GO:0070647	106	0.242
regulation of epithelial cell proliferation	GO:0050678	4	0.241
nephron epithelium development	GO:0072009	3	0.239	Zebrafish
dendrite morphogenesis	GO:0048813	199	0.231
negative regulation of neurogenesis	GO:0050768	53	0.228	Fly
muscle tissue development	GO:0060537	30	0.219
epithelial cell differentiation	GO:0030855	322	0.218	Zebrafish Fly
organ growth	GO:0035265	56	0.212	Fly
regulation of phosphorus metabolic process	GO:0051174	210	0.212	Mouse
notch signaling pathway	GO:0007219	120	0.209	Fly
cell proliferation	GO:0008283	299	0.209
wing disc morphogenesis	GO:0007472	344	0.203	Fly
intracellular signal transduction	GO:0035556	300	0.202	Fly
skin development	GO:0043588	65	0.200
striated muscle tissue development	GO:0014706	27	0.200
regulation of proteolysis	GO:0030162	87	0.197	Fly
embryonic development via the syncytial blastoderm	GO:0001700	148	0.197	Fly
tube development	GO:0035295	244	0.197	Zebrafish Fly
spermatogenesis	GO:0007283	200	0.195	Fly
protein ubiquitination	GO:0016567	70	0.192
regulation of peptidase activity	GO:0052547	39	0.186	Fly
epithelial cell proliferation	GO:0050673	15	0.185
establishment of localization in cell	GO:0051649	402	0.181
germ band shortening	GO:0007390	19	0.180
regulation of wnt signaling pathway	GO:0030111	68	0.178
protein complex biogenesis	GO:0070271	201	0.175	Mouse
regulation of myotube differentiation	GO:0010830	6	0.173	Fly
renal system development	GO:0072001	72	0.173	Zebrafish Mouse Fly
embryonic organ development	GO:0048568	50	0.170
hemopoiesis	GO:0030097	46	0.168	Mouse
regulation of photoreceptor cell differentiation	GO:0046532	34	0.168
immune effector process	GO:0002252	98	0.167
heterophilic cell cell adhesion via plasma membrane cell adhesion molecules	GO:0007157	8	0.166	Fly
regulation of response to external stimulus	GO:0032101	115	0.164
regulation of catalytic activity	GO:0050790	185	0.162	Fly
regionalization	GO:0003002	416	0.161	Fly
imaginal disc derived wing morphogenesis	GO:0007476	337	0.160	Fly
dendrite development	GO:0016358	204	0.158
neuron migration	GO:0001764	5	0.157	Mouse
developmental growth involved in morphogenesis	GO:0060560	65	0.156
extracellular matrix organization	GO:0030198	32	0.152	Zebrafish
morphogenesis of a branching structure	GO:0001763	45	0.152	Worm Fly
embryonic pattern specification	GO:0009880	174	0.151
negative regulation of epithelial cell proliferation	GO:0050680	4	0.150
cell cell adhesion	GO:0098609	26	0.149
cellular response to oxygen containing compound	GO:1901701	79	0.147
contractile actin filament bundle assembly	GO:0030038	1	0.147	Fly
positive regulation of signal transduction	GO:0009967	223	0.145	Fly
neuron fate commitment	GO:0048663	50	0.142
appendage development	GO:0048736	401	0.140	Fly
apoptotic process	GO:0006915	159	0.138
visceral muscle development	GO:0007522	14	0.136	Fly
positive regulation of rna biosynthetic process	GO:1902680	266	0.135
biological adhesion	GO:0022610	138	0.134
positive regulation of response to stimulus	GO:0048584	323	0.130	Fly
negative regulation of cell differentiation	GO:0045596	143	0.130	Fly
regulation of actin cytoskeleton organization	GO:0032956	42	0.130	Mouse Fly
salivary gland morphogenesis	GO:0007435	145	0.127
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.127	Fly
regulation of actin filament based process	GO:0032970	42	0.126	Mouse Fly
embryonic morphogenesis	GO:0048598	206	0.126	Fly
positive regulation of cell projection organization	GO:0031346	29	0.126
larval development	GO:0002164	104	0.125	Fly
regulation of cell size	GO:0008361	63	0.124
cuticle pattern formation	GO:0035017	27	0.122	Fly
regulation of cellular protein metabolic process	GO:0032268	243	0.121	Mouse Fly
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.121	Fly
regulation of cell fate commitment	GO:0010453	29	0.121	Fly
wnt signaling pathway	GO:0016055	98	0.121
regulation of actin polymerization or depolymerization	GO:0008064	27	0.120	Mouse
death	GO:0016265	284	0.119
camera type eye development	GO:0043010	4	0.119
positive regulation of biosynthetic process	GO:0009891	316	0.118
regulation of r7 cell differentiation	GO:0045676	15	0.117
positive regulation of gene expression	GO:0010628	290	0.116
positive regulation of cellular protein metabolic process	GO:0032270	118	0.115	Fly
response to wounding	GO:0009611	94	0.115	Fly
larval visceral muscle development	GO:0007523	9	0.115	Fly
negative regulation of fusion cell fate specification	GO:0035157	2	0.115	Fly
regulation of defense response	GO:0031347	102	0.111
regulation of molecular function	GO:0065009	217	0.111	Fly
regulation of apoptotic signaling pathway	GO:2001233	10	0.111
regulation of protein localization	GO:0032880	76	0.110
positive regulation of transcription dna templated	GO:0045893	266	0.110
cell cell junction organization	GO:0045216	55	0.109	Fly
specification of organ identity	GO:0010092	3	0.108
hematopoietic or lymphoid organ development	GO:0048534	57	0.108	Mouse
negative regulation of gene expression	GO:0010629	387	0.107
compound eye photoreceptor fate commitment	GO:0001752	36	0.107
negative regulation of cell development	GO:0010721	62	0.106	Fly
organophosphate metabolic process	GO:0019637	195	0.105
hindbrain development	GO:0030902	2	0.104
positive regulation of developmental process	GO:0051094	143	0.101
positive regulation of cell differentiation	GO:0045597	64	0.101
epithelial cell type specification open tracheal system	GO:0035153	11	0.101	Fly
positive regulation of hydrolase activity	GO:0051345	78	0.099	Fly
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.098
secretion	GO:0046903	109	0.097
regulation of cellular component biogenesis	GO:0044087	201	0.097	Mouse
malpighian tubule morphogenesis	GO:0007443	44	0.096
regulation of epidermal growth factor receptor signaling pathway	GO:0042058	42	0.094	Fly
single organism catabolic process	GO:0044712	228	0.093
regulation of cell death	GO:0010941	173	0.093
compound eye retinal cell programmed cell death	GO:0046667	23	0.093
synapse organization	GO:0050808	196	0.093	Worm
chromosome organization	GO:0051276	360	0.092
negative regulation of developmental process	GO:0051093	201	0.092	Fly
positive regulation of cell death	GO:0010942	69	0.092
actin filament polymerization	GO:0030041	27	0.090	Mouse
regulation of phosphate metabolic process	GO:0019220	210	0.090	Mouse
mapk cascade	GO:0000165	107	0.090
nucleobase containing small molecule metabolic process	GO:0055086	174	0.090
positive regulation of programmed cell death	GO:0043068	62	0.089
extrinsic apoptotic signaling pathway	GO:0097191	1	0.087
cell death	GO:0008219	279	0.087
regulation of muscle tissue development	GO:1901861	5	0.087
peptidyl amino acid modification	GO:0018193	105	0.085
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.085
cuticle development	GO:0042335	86	0.084	Fly
negative regulation of protein phosphorylation	GO:0001933	17	0.084	Mouse
secretion by cell	GO:0032940	101	0.083
genital disc development	GO:0035215	44	0.078
cellular protein modification process	GO:0006464	438	0.078	Mouse
negative regulation of cell cycle process	GO:0010948	109	0.077
hippo signaling	GO:0035329	20	0.076	Fly
mushroom body development	GO:0016319	70	0.075	Fly
embryo development ending in birth or egg hatching	GO:0009792	152	0.075	Fly
regulation of actin filament polymerization	GO:0030833	25	0.074	Mouse
positive regulation of protein metabolic process	GO:0051247	128	0.074	Fly
regulation of cysteine type endopeptidase activity	GO:2000116	27	0.074
malpighian tubule development	GO:0072002	64	0.073	Fly
stem cell maintenance	GO:0019827	67	0.072
positive regulation of proteolysis	GO:0045862	52	0.071	Fly
regulation of immune response	GO:0050776	118	0.069
protein maturation	GO:0051604	71	0.069
immune system process	GO:0002376	347	0.069	Mouse
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.069
protein complex assembly	GO:0006461	200	0.068	Mouse
regulation of response to stress	GO:0080134	200	0.068
eye photoreceptor cell fate commitment	GO:0042706	37	0.068
response to nutrient levels	GO:0031667	114	0.067
cellular protein complex assembly	GO:0043623	71	0.067	Mouse
protein modification process	GO:0036211	438	0.067	Mouse
telencephalon development	GO:0021537	2	0.067
mesoderm development	GO:0007498	78	0.066
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.066
regulation of protein phosphorylation	GO:0001932	64	0.066	Mouse
aging	GO:0007568	143	0.064
eggshell chorion assembly	GO:0007306	66	0.064	Fly
regulation of cell cell adhesion	GO:0022407	21	0.064
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.063
negative regulation of developmental growth	GO:0048640	64	0.063	Fly
stress activated protein kinase signaling cascade	GO:0031098	55	0.063
programmed cell death	GO:0012501	257	0.063
posttranscriptional regulation of gene expression	GO:0010608	145	0.063
forebrain development	GO:0030900	2	0.063
positive regulation of neuron differentiation	GO:0045666	26	0.062
maintenance of location	GO:0051235	73	0.060
cell division	GO:0051301	248	0.060
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.060
regulation of protein kinase activity	GO:0045859	51	0.060
negative regulation of cell death	GO:0060548	81	0.060
inter male aggressive behavior	GO:0002121	60	0.059	Mouse Fly
regulation of transferase activity	GO:0051338	58	0.059
regulation of cytoskeleton organization	GO:0051493	89	0.057	Mouse Fly
negative regulation of cellular protein metabolic process	GO:0032269	85	0.057	Mouse
regulation of synapse structure and activity	GO:0050803	128	0.056
regulation of hydrolase activity	GO:0051336	97	0.056	Fly
inositol lipid mediated signaling	GO:0048017	4	0.056
multi organism behavior	GO:0051705	175	0.055	Mouse Fly
substrate dependent cell migration	GO:0006929	3	0.054
eye photoreceptor cell development	GO:0042462	81	0.053
chaeta development	GO:0022416	97	0.052
regulation of growth	GO:0040008	233	0.052	Fly
centrosome duplication	GO:0051298	121	0.052
anterior posterior pattern specification	GO:0009952	136	0.051
regulation of localization	GO:0032879	275	0.051
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.051
positive regulation of immune system process	GO:0002684	68	0.051
digestive tract morphogenesis	GO:0048546	127	0.050
negative regulation of signaling	GO:0023057	219	0.050	Fly
positive regulation of neuron apoptotic process	GO:0043525	1	0.050
negative regulation of rna biosynthetic process	GO:1902679	240	0.049
establishment or maintenance of cell polarity	GO:0007163	167	0.049	Fly
response to organic substance	GO:0010033	284	0.049
regulation of striated muscle tissue development	GO:0016202	5	0.049
regulation of dendrite morphogenesis	GO:0048814	28	0.049
endodermal cell fate commitment	GO:0001711	3	0.048
defense response	GO:0006952	300	0.047
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.047
positive regulation of developmental growth	GO:0048639	62	0.047
compound eye photoreceptor development	GO:0042051	78	0.047
pigmentation	GO:0043473	75	0.046
glutamate secretion	GO:0014047	1	0.046
cellular catabolic process	GO:0044248	372	0.046
purine containing compound metabolic process	GO:0072521	155	0.045
chemotaxis	GO:0006935	249	0.045
regulation of smoothened signaling pathway	GO:0008589	28	0.045
positive regulation of cell communication	GO:0010647	250	0.044	Fly
regulation of erbb signaling pathway	GO:1901184	42	0.044	Fly
protein processing	GO:0016485	68	0.044
cell maturation	GO:0048469	144	0.044
regulation of muscle organ development	GO:0048634	13	0.043
axis specification	GO:0009798	167	0.043
innate immune response	GO:0045087	144	0.043
camera type eye morphogenesis	GO:0048593	2	0.043
membrane organization	GO:0061024	112	0.043
developmental growth	GO:0048589	280	0.042	Fly
salivary gland development	GO:0007431	162	0.042
positive regulation of cellular biosynthetic process	GO:0031328	316	0.042
compound eye cone cell differentiation	GO:0042675	13	0.042
blastoderm segmentation	GO:0007350	159	0.042
circadian rhythm	GO:0007623	105	0.042
epithelial cell development	GO:0002064	274	0.042	Zebrafish Fly
heart development	GO:0007507	82	0.042
regulation of cell cycle process	GO:0010564	181	0.041
vesicle mediated transport	GO:0016192	381	0.041
regulation of cellular ketone metabolic process	GO:0010565	3	0.041
regulation of apoptotic process	GO:0042981	130	0.040
regulation of stress activated protein kinase signaling cascade	GO:0070302	42	0.039
positive regulation of cell migration	GO:0030335	2	0.039
regulation of cell adhesion	GO:0030155	27	0.039
phosphatidylinositol 3 kinase signaling	GO:0014065	4	0.039
positive regulation of cell motility	GO:2000147	3	0.039
negative regulation of epidermal growth factor receptor signaling pathway	GO:0042059	29	0.039	Fly
organonitrogen compound metabolic process	GO:1901564	318	0.039
skeletal muscle organ development	GO:0060538	48	0.039
cell cycle phase transition	GO:0044770	140	0.038
negative regulation of biosynthetic process	GO:0009890	277	0.038
endocytosis	GO:0006897	310	0.038
developmental maturation	GO:0021700	172	0.038
stem cell development	GO:0048864	79	0.038
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.037	Fly
organic substance transport	GO:0071702	257	0.037
phosphorylation	GO:0016310	294	0.037	Mouse
cellular macromolecular complex assembly	GO:0034622	153	0.037	Mouse
response to abiotic stimulus	GO:0009628	341	0.037
regulation of intracellular signal transduction	GO:1902531	236	0.036	Fly
negative regulation of programmed cell death	GO:0043069	72	0.036
leg disc morphogenesis	GO:0007478	80	0.036
retina development in camera type eye	GO:0060041	4	0.036
regulation of striated muscle cell differentiation	GO:0051153	8	0.036	Fly
cell junction assembly	GO:0034329	42	0.035	Fly
negative regulation of cell cell adhesion	GO:0022408	8	0.035
regulation of cellular amine metabolic process	GO:0033238	3	0.035
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.035
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.035
positive regulation of protein kinase activity	GO:0045860	25	0.035
regulation of cell shape	GO:0008360	113	0.035	Fly
catabolic process	GO:0009056	409	0.035
positive regulation of nervous system development	GO:0051962	69	0.034
imaginal disc derived wing vein morphogenesis	GO:0008586	44	0.034
microtubule organizing center organization	GO:0031023	168	0.034
positive regulation of phosphorus metabolic process	GO:0010562	139	0.034
regulation of circadian rhythm	GO:0042752	49	0.034
canonical wnt signaling pathway	GO:0060070	21	0.034
imaginal disc derived wing vein specification	GO:0007474	48	0.033
cell cell junction assembly	GO:0007043	38	0.033	Fly
regulation of developmental growth	GO:0048638	174	0.033	Fly
nephrocyte differentiation	GO:0061319	12	0.033	Fly
positive regulation of compound eye retinal cell programmed cell death	GO:0046672	9	0.033
determination of adult lifespan	GO:0008340	137	0.033
branching involved in open tracheal system development	GO:0060446	45	0.033	Fly
organic substance catabolic process	GO:1901575	308	0.033
regulation of protein transport	GO:0051223	57	0.032
negative regulation of catalytic activity	GO:0043086	42	0.032
immune system development	GO:0002520	57	0.032	Mouse
regeneration	GO:0031099	16	0.032
ribonucleoside metabolic process	GO:0009119	127	0.032
positive regulation of apoptotic process	GO:0043065	47	0.032
endomembrane system organization	GO:0010256	119	0.032
kidney morphogenesis	GO:0060993	3	0.032
purine ribonucleotide catabolic process	GO:0009154	109	0.032
positive regulation of cellular component biogenesis	GO:0044089	80	0.032	Mouse
cellular response to dna damage stimulus	GO:0006974	223	0.032
nucleoside metabolic process	GO:0009116	127	0.031
negative regulation of growth	GO:0045926	84	0.031	Fly
positive regulation of protein complex assembly	GO:0031334	22	0.031	Mouse
positive regulation of muscle organ development	GO:0048636	6	0.031
regulation of eye photoreceptor cell development	GO:0042478	13	0.031
regulation of cell cycle phase transition	GO:1901987	130	0.031
eye antennal disc development	GO:0035214	60	0.031
jnk cascade	GO:0007254	50	0.030
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	12	0.030
positive regulation of protein modification process	GO:0031401	58	0.030
regulation of cellular component movement	GO:0051270	42	0.030
protein localization to organelle	GO:0033365	82	0.030
renal filtration	GO:0097205	7	0.030	Fly
regulation of compound eye photoreceptor development	GO:0045314	12	0.029
regulation of imaginal disc growth	GO:0045570	26	0.029
nuclear division	GO:0000280	332	0.029
cell fate determination	GO:0001709	91	0.029
reproductive structure development	GO:0048608	74	0.029
regulation of cell motility	GO:2000145	23	0.029
regulation of canonical wnt signaling pathway	GO:0060828	15	0.029
germarium derived egg chamber formation	GO:0007293	101	0.029
regulation of muscle cell differentiation	GO:0051147	8	0.029	Fly
stress activated mapk cascade	GO:0051403	52	0.028
amine metabolic process	GO:0009308	12	0.028
intracellular transport	GO:0046907	228	0.028
nucleus localization	GO:0051647	34	0.028
phosphatidylinositol mediated signaling	GO:0048015	4	0.028
cellular response to organic substance	GO:0071310	132	0.028
cell growth	GO:0016049	108	0.028
wing disc pattern formation	GO:0035222	66	0.028
wound healing	GO:0042060	75	0.028	Fly
regulation of protein modification process	GO:0031399	112	0.028	Mouse
smoothened signaling pathway	GO:0007224	49	0.028
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	18	0.028
regulation of syncytium formation by plasma membrane fusion	GO:0060142	6	0.028	Fly
positive regulation of protein phosphorylation	GO:0001934	34	0.028
positive regulation of kinase activity	GO:0033674	25	0.028
negative regulation of phosphate metabolic process	GO:0045936	45	0.028	Mouse
regulation of secretion	GO:0051046	44	0.027
dna metabolic process	GO:0006259	227	0.027
regulation of axonogenesis	GO:0050770	32	0.027
protein catabolic process	GO:0030163	101	0.026
regulation of actin filament length	GO:0030832	27	0.026	Mouse
negative regulation of hippo signaling	GO:0035331	5	0.026	Fly
regulation of cellular response to growth factor stimulus	GO:0090287	13	0.026
cellular response to endogenous stimulus	GO:0071495	80	0.026
regulation of mitosis	GO:0007088	56	0.025
positive regulation of transferase activity	GO:0051347	26	0.025
regulation of chemotaxis	GO:0050920	12	0.025
single organism membrane organization	GO:0044802	93	0.025
regulation of cell cycle	GO:0051726	291	0.025
positive regulation of neuron projection development	GO:0010976	14	0.025
establishment of protein localization	GO:0045184	163	0.025
monocarboxylic acid transport	GO:0015718	3	0.025
endodermal cell differentiation	GO:0035987	3	0.024
macromolecule catabolic process	GO:0009057	161	0.024
tripartite regional subdivision	GO:0007351	103	0.024
branch fusion open tracheal system	GO:0035147	17	0.024	Fly
cell projection assembly	GO:0030031	94	0.024
oxoacid metabolic process	GO:0043436	103	0.024
negative regulation of cellular biosynthetic process	GO:0031327	277	0.024
sensory perception of mechanical stimulus	GO:0050954	72	0.023
regulation of cell migration	GO:0030334	22	0.023
leg disc development	GO:0035218	92	0.023
renal tubule morphogenesis	GO:0061333	44	0.023
cellular protein catabolic process	GO:0044257	83	0.023
nucleoside phosphate metabolic process	GO:0006753	162	0.023
cell type specific apoptotic process	GO:0097285	38	0.023
protein phosphorylation	GO:0006468	169	0.023	Mouse
regulation of dendrite development	GO:0050773	37	0.023
positive regulation of neurogenesis	GO:0050769	41	0.023
mitotic cell cycle phase transition	GO:0044772	138	0.023
negative regulation of cellular component organization	GO:0051129	108	0.022
digestive system development	GO:0055123	149	0.022
cellular amide metabolic process	GO:0043603	80	0.022
protein polymerization	GO:0051258	42	0.022	Mouse
mitotic sister chromatid segregation	GO:0000070	87	0.022
actin polymerization or depolymerization	GO:0008154	31	0.022	Mouse
regulation of cellular localization	GO:0060341	136	0.022
regulation of catabolic process	GO:0009894	170	0.022
positive regulation of catalytic activity	GO:0043085	118	0.022	Fly
homeostatic process	GO:0042592	199	0.022
cellular response to chemical stimulus	GO:0070887	199	0.021
columnar cuboidal epithelial cell development	GO:0002066	249	0.021	Fly
axon extension	GO:0048675	32	0.021
negative regulation of apoptotic process	GO:0043066	63	0.021
positive regulation of r7 cell differentiation	GO:0045678	7	0.021
positive regulation of mapk cascade	GO:0043410	63	0.021
negative regulation of wnt signaling pathway	GO:0030178	28	0.021
regulation of cell growth	GO:0001558	43	0.021
organic acid metabolic process	GO:0006082	103	0.021
regulation of autophagy	GO:0010506	62	0.021
positive regulation of response to external stimulus	GO:0032103	44	0.021
negative regulation of transforming growth factor beta receptor signaling pathway	GO:0030512	4	0.021
cell aging	GO:0007569	2	0.021

rst disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.098
cardiovascular system disease	DOID:1287	0.029
disease of cellular proliferation	DOID:14566	0.027
cancer	DOID:162	0.027
organ system cancer	DOID:0050686	0.027

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