Drosophila melanogaster

125 known processes

Mical (Dmel_CG33208)

Molecule interacting with CasL

(Aliases: CG33190,CG18667,CG33208,MICAL,CG33186,CG18668,mical,CG18484,milch,Dmel\CG33208,CG11685,CG11687)

Mical biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
axon developmentGO:00615642971.000
synapse organizationGO:00508081961.000
motor neuron axon guidanceGO:0008045581.000
axonogenesisGO:00074092900.999
dendrite developmentGO:00163582040.997
neuron projection guidanceGO:00974852410.996
muscle structure developmentGO:00610612240.989
synapse assemblyGO:00074161430.984
dendrite morphogenesisGO:00488131990.977
chemotaxisGO:00069352490.944
photoreceptor cell axon guidanceGO:0072499230.935
axon guidanceGO:00074112330.933
regulation of cellular component biogenesisGO:00440872010.918
taxisGO:00423303040.915
actomyosin structure organizationGO:0031032560.911
regulation of cell projection organizationGO:0031344920.908
regulation of neuron projection developmentGO:0010975690.902
regulation of nervous system developmentGO:00519602480.893
actin filament based processGO:00300292200.891
muscle cell differentiationGO:00426921030.870
regulation of synaptic growth at neuromuscular junctionGO:0008582890.842
regulation of dendrite morphogenesisGO:0048814280.839
regulation of multicellular organismal developmentGO:20000264140.826
regulation of cell morphogenesis involved in differentiationGO:0010769610.824
positive regulation of cellular component organizationGO:00511301560.822
cellular macromolecular complex assemblyGO:00346221530.816
olfactory bulb axon guidanceGO:007167830.791
regulation of cell differentiationGO:00455953020.712
muscle attachmentGO:0016203360.697
regulation of cell morphogenesisGO:00226041630.684
regulation of synapse assemblyGO:0051963940.679
regulation of neuron differentiationGO:00456641030.675
macromolecular complex assemblyGO:00650032560.674
neuromuscular junction developmentGO:00075281490.654
regulation of anatomical structure morphogenesisGO:00226032420.646
synaptic growth at neuromuscular junctionGO:00511241190.644
striated muscle cell differentiationGO:0051146900.625
positive regulation of nervous system developmentGO:0051962690.622
positive regulation of dendrite morphogenesisGO:005077590.616
regulation of photoreceptor cell axon guidanceGO:200028950.610
myofibril assemblyGO:0030239360.560
regulation of cell developmentGO:00602842150.559
regulation of synapse structure and activityGO:00508031280.545
regulation of axon guidanceGO:1902667100.513
regulation of cytoskeleton organizationGO:0051493890.508
positive regulation of axonogenesisGO:005077220.506
cell motilityGO:00488702510.502
negative regulation of cell communicationGO:00106482230.494
sarcomere organizationGO:0045214260.491
protein complex biogenesisGO:00702712010.486
cell migrationGO:00164772380.470
regulation of neurogenesisGO:00507671580.435
regulation of axon extension involved in axon guidanceGO:004884140.424
neuron recognitionGO:00080381010.372
cellular protein complex assemblyGO:0043623710.357
axon extension involved in axon guidanceGO:0048846100.356
intracellular signal transductionGO:00355563000.354
regulation of axonogenesisGO:0050770320.348
somatic muscle developmentGO:0007525660.322
regulation of filopodium assemblyGO:0051489240.320
appendage developmentGO:00487364010.316
protein depolymerizationGO:0051261310.313
positive regulation of cellular component biogenesisGO:0044089800.310
protein complex assemblyGO:00064612000.305
dendrite guidanceGO:0070983210.301
actin filament organizationGO:00070151260.264
cell recognitionGO:00080371020.260
semaphorin plexin signaling pathwayGO:007152640.247
developmental growth involved in morphogenesisGO:0060560650.236
adult locomotory behaviorGO:0008344760.222
regulation of anatomical structure sizeGO:00900661630.212
regulation of synapse organizationGO:00508071100.212
regulation of localizationGO:00328792750.210
appendage morphogenesisGO:00351073970.200
positive regulation of actin filament polymerizationGO:0030838110.194
protein modification processGO:00362114380.189
positive regulation of biosynthetic processGO:00098913160.187
Human
actin polymerization or depolymerizationGO:0008154310.184
negative regulation of cellular component organizationGO:00511291080.180
positive regulation of cell morphogenesis involved in differentiationGO:0010770120.177
regulation of cellular component movementGO:0051270420.177
respiratory system developmentGO:00605412130.175
positive regulation of multicellular organismal processGO:00512401430.158
positive regulation of axon guidanceGO:190266910.151
negative regulation of signalingGO:00230572190.151
regulation of actin filament polymerizationGO:0030833250.149
regulation of actin cytoskeleton organizationGO:0032956420.146
negative regulation of cytoskeleton organizationGO:0051494300.145
localization of cellGO:00516742570.142
negative regulation of growthGO:0045926840.140
negative regulation of multicellular organismal processGO:00512411420.133
positive regulation of cell projection organizationGO:0031346290.130
regulation of dendrite developmentGO:0050773370.128
positive regulation of developmental processGO:00510941430.128
positive regulation of synapse assemblyGO:0051965290.128
growthGO:00400073590.126
actin cytoskeleton organizationGO:00300362060.124
regulation of chemotaxisGO:0050920120.118
regulation of transcription from rna polymerase ii promoterGO:00063573780.116
Human
negative regulation of synaptic growth at neuromuscular junctionGO:0045886390.116
actin filament polymerizationGO:0030041270.115
tube developmentGO:00352952440.110
positive regulation of neuron differentiationGO:0045666260.110
positive regulation of cell communicationGO:00106472500.106
positive regulation of cell developmentGO:0010720610.104
regulation of locomotionGO:0040012420.098
chaeta morphogenesisGO:0008407420.098
regulation of neuron deathGO:1901214260.096
spermatid differentiationGO:00485151140.093
regulation of actin filament lengthGO:0030832270.093
protein localizationGO:00081042840.093
protein modification by small protein conjugationGO:0032446790.092
striated muscle myosin thick filament assemblyGO:007168830.092
regulation of actin filament based processGO:0032970420.090
regulation of protein phosphorylationGO:0001932640.086
Mouse
intracellular mrna localizationGO:0008298660.084
secretion by cellGO:00329401010.084
cell deathGO:00082192790.082
Mouse
regulation of vesicle mediated transportGO:0060627590.082
regulation of protein complex disassemblyGO:0043244290.080
larval developmentGO:00021641040.080
establishment of localization in cellGO:00516494020.079
receptor clusteringGO:004311330.078
negative regulation of synapse assemblyGO:0051964390.078
morphogenesis of an epitheliumGO:00020092760.076
regulation of growthGO:00400082330.074
axon choice point recognitionGO:0016198260.074
positive regulation of transportGO:0051050920.073
post embryonic appendage morphogenesisGO:00351203850.072
negative regulation of epidermal growth factor receptor signaling pathwayGO:0042059290.070
cellular protein complex disassemblyGO:0043624350.070
regulation of cell motilityGO:2000145230.069
axon midline choice point recognitionGO:0016199260.068
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178650.068
extrinsic apoptotic signaling pathwayGO:009719110.067
positive regulation of apoptotic signaling pathwayGO:200123540.067
organelle assemblyGO:00709251980.067
positive regulation of axon extensionGO:004577320.065
protein modification by small protein conjugation or removalGO:00706471060.065
negative regulation of developmental processGO:00510932010.063
positive regulation of neuron projection developmentGO:0010976140.063
positive regulation of signalingGO:00230562430.063
axonal defasciculationGO:0007414120.063
cell maturationGO:00484691440.062
organic substance catabolic processGO:19015753080.061
axon extensionGO:0048675320.061
locomotory behaviorGO:00076261760.059
embryonic development via the syncytial blastodermGO:00017001480.059
enzyme linked receptor protein signaling pathwayGO:00071671790.058
circulatory system developmentGO:0072359820.058
retinal ganglion cell axon guidanceGO:0031290120.058
epithelial cell differentiationGO:00308553220.057
transcription from rna polymerase ii promoterGO:00063663680.054
Human
negative regulation of nervous system developmentGO:0051961920.054
imaginal disc derived appendage morphogenesisGO:00351143950.054
positive regulation of signal transductionGO:00099672230.053
neuron projection extensionGO:1990138320.053
positive regulation of neurogenesisGO:0050769410.053
positive regulation of macromolecule metabolic processGO:00106044050.051
Human
regulation of cell migrationGO:0030334220.050
central nervous system developmentGO:00074172010.050
purine ribonucleoside monophosphate metabolic processGO:0009167500.050
purine ribonucleoside metabolic processGO:00461281270.050
protein ubiquitinationGO:0016567700.050
cellular catabolic processGO:00442483720.050
dorsal ventral axon guidanceGO:003356320.049
cell adhesionGO:00071551360.049
positive regulation of response to stimulusGO:00485843230.048
regulation of organelle organizationGO:00330431960.048
catabolic processGO:00090564090.048
regulation of cellular localizationGO:00603411360.046
positive regulation of nucleobase containing compound metabolic processGO:00459353320.045
Human
negative regulation of response to stimulusGO:00485852580.045
heart developmentGO:0007507820.044
regulation of behaviorGO:0050795750.043
regulation of cellular component sizeGO:0032535980.043
developmental growthGO:00485892800.043
secretionGO:00469031090.043
maintenance of locationGO:0051235730.043
imaginal disc derived appendage developmentGO:00487373990.042
sex differentiationGO:0007548810.042
single organism carbohydrate metabolic processGO:0044723720.041
cellular component assembly involved in morphogenesisGO:00109271510.041
muscle cell developmentGO:0055001500.041
organelle localizationGO:00516401480.040
regulation of microtubule cytoskeleton organizationGO:0070507410.040
positive regulation of filopodium assemblyGO:0051491150.040
purine nucleoside triphosphate metabolic processGO:00091441190.040
organophosphate metabolic processGO:00196371950.039
organonitrogen compound metabolic processGO:19015643180.039
single organism catabolic processGO:00447122280.038
spinal cord developmentGO:002151010.038
inositol lipid mediated signalingGO:004801740.038
negative regulation of axon extensionGO:003051730.038
establishment of protein localizationGO:00451841630.038
embryonic organ developmentGO:0048568500.037
eye developmentGO:00016543230.037
endocytosisGO:00068973100.037
cellular nitrogen compound catabolic processGO:00442701650.036
protein polymerizationGO:0051258420.036
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.036
Human
synaptic vesicle localizationGO:0097479530.035
negative regulation of cell developmentGO:0010721620.035
neuron deathGO:0070997270.034
negative regulation of signal transductionGO:00099682060.034
tissue morphogenesisGO:00487292970.034
positive regulation of cell motilityGO:200014730.034
eye antennal disc developmentGO:0035214600.034
regulation of actin polymerization or depolymerizationGO:0008064270.034
establishment of synaptic vesicle localizationGO:0097480500.033
substrate dependent cell migrationGO:000692930.033
cell growthGO:00160491080.033
compound eye developmentGO:00487493070.033
actin filament bundle organizationGO:0061572280.033
synaptic vesicle recyclingGO:0036465280.032
hematopoietic progenitor cell differentiationGO:000224410.031
negative regulation of protein metabolic processGO:0051248850.031
Mouse
filopodium assemblyGO:0046847330.031
cellular protein modification processGO:00064644380.031
neuron projection extension involved in neuron projection guidanceGO:1902284100.031
single organism intracellular transportGO:19025822070.031
ribonucleotide catabolic processGO:00092611090.031
protein transportGO:00150311550.031
protein phosphorylationGO:00064681690.030
Mouse
flight behaviorGO:0007629260.030
regulation of developmental growthGO:00486381740.029
morphogenesis of a branching structureGO:0001763450.029
regulation of cell shapeGO:00083601130.029
oocyte differentiationGO:00099941450.029
positive regulation of protein complex assemblyGO:0031334220.029
central nervous system projection neuron axonogenesisGO:002195260.029
semaphorin plexin signaling pathway involved in regulation of photoreceptor cell axon guidanceGO:200030520.028
adult behaviorGO:00305341370.028
purine ribonucleoside triphosphate metabolic processGO:00092051190.028
regulation of intracellular signal transductionGO:19025312360.028
positive regulation of developmental growthGO:0048639620.028
body morphogenesisGO:001017120.028
neuron remodelingGO:0016322290.028
positive regulation of cell migrationGO:003033520.028
drinking behaviorGO:004275620.027
negative regulation of gene expressionGO:00106293870.027
Mouse
chaeta developmentGO:0022416970.027
regulation of transforming growth factor beta receptor signaling pathwayGO:001701560.027
blood circulationGO:0008015260.027
positive regulation of synaptic growth at neuromuscular junctionGO:0045887260.027
response to organic substanceGO:00100332840.026
small molecule metabolic processGO:00442813050.026
central nervous system neuron axonogenesisGO:002195570.026
anatomical structure homeostasisGO:0060249970.026
heterocycle catabolic processGO:00467001660.026
nucleotide catabolic processGO:00091661090.026
erbb signaling pathwayGO:0038127580.026
regulation of cellular protein metabolic processGO:00322682430.025
Mouse
muscle thin filament assemblyGO:007168950.025
purine ribonucleoside catabolic processGO:00461301120.025
organic substance transportGO:00717022570.025
protein catabolic processGO:00301631010.025
hair cell differentiationGO:0035315470.024
negative regulation of cell migrationGO:003033650.024
positive regulation of organelle organizationGO:0010638650.024
regulation of axon extensionGO:003051680.024
regulation of phosphorus metabolic processGO:00511742100.024
Mouse
regulation of mitotic cell cycle phase transitionGO:19019901300.024
antennal morphogenesisGO:0048800140.024
embryo development ending in birth or egg hatchingGO:00097921520.024
cytoskeleton dependent intracellular transportGO:0030705440.024
cellular macromolecule localizationGO:00707272200.024
regulation of neuron apoptotic processGO:0043523160.024
vesicle localizationGO:0051648550.024
regulation of apoptotic processGO:00429811300.023
Mouse
regulation of secretion by cellGO:1903530390.023
regulation of catalytic activityGO:00507901850.023
Mouse
forebrain developmentGO:003090020.023
regulation of response to stressGO:00801342000.022
eye antennal disc morphogenesisGO:0007455340.022
ribonucleoside triphosphate metabolic processGO:00091991190.022
positive regulation of growthGO:0045927750.022
regulation of excitatory postsynaptic membrane potentialGO:006007930.022
signal transduction in response to dna damageGO:004277030.022
positive regulation of cell differentiationGO:0045597640.022
regulation of protein polymerizationGO:0032271280.021
regulation of cell growthGO:0001558430.021
cellular protein localizationGO:00346131600.021
cranial nerve developmentGO:002154510.021
modification dependent macromolecule catabolic processGO:0043632790.021
integrin mediated signaling pathwayGO:000722930.021
synaptic vesicle exocytosisGO:0016079160.021
positive regulation of nucleic acid templated transcriptionGO:19035082660.021
Human
neurotransmitter gated ion channel clusteringGO:007257820.020
regulation of extent of cell growthGO:006138780.020
regulation of cell projection assemblyGO:0060491300.020
nerve developmentGO:002167560.020
regulation of mitotic cell cycleGO:00073461900.020
mapk cascadeGO:00001651070.020
muscle organ developmentGO:00075171270.020
regulation of cellular response to stressGO:0080135890.019
imaginal disc derived wing morphogenesisGO:00074763370.019
epithelial tube morphogenesisGO:0060562880.019
nucleoside monophosphate catabolic processGO:0009125390.019
microtubule polymerization or depolymerizationGO:0031109390.019
negative regulation of protein depolymerizationGO:1901880230.019
cardiovascular system developmentGO:0072358820.019
organophosphate catabolic processGO:00464341120.019
establishment of nucleus localizationGO:0040023260.018
single organism cellular localizationGO:19025801800.018
regulation of protein localizationGO:0032880760.018
bmp signaling pathwayGO:0030509270.018
transmembrane transportGO:00550851390.018
phosphorylationGO:00163102940.018
Mouse
regulation of synaptic transmissionGO:0050804690.017
collateral sproutingGO:004866830.017
regulation of cellular amine metabolic processGO:003323830.017
organic cyclic compound catabolic processGO:19013611680.017
compound eye morphogenesisGO:00017452490.017
positive regulation of cell deathGO:0010942690.017
positive regulation of cytoskeleton organizationGO:0051495210.017
branching morphogenesis of an epithelial tubeGO:0048754450.017
regulation of cell substrate adhesionGO:001081020.017
purine ribonucleotide metabolic processGO:00091501450.017
formation of anatomical boundaryGO:0048859370.017
cytoplasmic transportGO:00164821300.017
negative regulation of molecular functionGO:0044092510.017
Mouse
positive regulation of wnt signaling pathwayGO:0030177250.016
glycoprotein metabolic processGO:0009100410.016
regulation of microtubule polymerization or depolymerizationGO:0031110270.016
regulation of cell cycleGO:00517262910.016
positive regulation of intracellular signal transductionGO:19025331160.016
positive regulation of protein polymerizationGO:0032273140.016
salivary gland boundary specificationGO:000743280.016
cell projection assemblyGO:0030031940.016
maintenance of protein location in cellGO:0032507260.016
synaptic transmissionGO:00072682880.016
protein secretionGO:0009306450.016
striated muscle cell developmentGO:0055002500.015
actin filament bundle assemblyGO:0051017260.015
cytoplasmic microtubule organizationGO:0031122220.015
carbohydrate derivative catabolic processGO:19011361180.015
purine nucleotide catabolic processGO:00061951090.015
developmental cell growthGO:0048588520.015
deathGO:00162652840.015
Mouse
regulation of muscle organ developmentGO:0048634130.015
purine nucleoside monophosphate metabolic processGO:0009126500.015
cell cell adhesion via plasma membrane adhesion moleculesGO:0098742260.015
gliogenesisGO:0042063800.015
regulation of protein complex assemblyGO:0043254420.015
negative regulation of organelle organizationGO:0010639560.015
carbohydrate derivative metabolic processGO:19011352170.014
nuclear transportGO:0051169720.014
hematopoietic or lymphoid organ developmentGO:0048534570.014
positive regulation of endocytosisGO:0045807220.014
outflow tract morphogenesisGO:000315140.014
photoreceptor cell developmentGO:0042461960.014
translationGO:0006412690.014
positive regulation of cellular amine metabolic processGO:003324000.014
negative regulation of rho protein signal transductionGO:003502410.014
synaptic target recognitionGO:0008039450.014
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090101180.014
regulation of cell matrix adhesionGO:000195210.014
regulation of microtubule based processGO:0032886490.014
nucleoside phosphate catabolic processGO:19012921100.014
regulation of rho protein signal transductionGO:0035023200.014
gonad developmentGO:0008406500.014
oxoacid metabolic processGO:00434361030.013
synaptic vesicle transportGO:0048489500.013
wnt signaling pathwayGO:0016055980.013
purine nucleoside catabolic processGO:00061521120.013
regulation of wnt signaling pathwayGO:0030111680.013
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092380.013
glycoprotein biosynthetic processGO:0009101410.013
open tracheal system developmentGO:00074242040.013
establishment of protein localization to organelleGO:0072594620.013
cellular amine metabolic processGO:0044106120.013
brain developmentGO:00074201200.013
ribonucleoside monophosphate catabolic processGO:0009158390.013
epidermis developmentGO:0008544650.013
regulation of cell deathGO:00109411730.013
Mouse
embryonic morphogenesisGO:00485982060.013
single organism membrane organizationGO:0044802930.013
regulation of establishment of protein localizationGO:0070201610.013
chromatin modificationGO:00165681470.013
dna packagingGO:0006323910.012
peptidyl amino acid modificationGO:00181931050.012
ribonucleoside triphosphate catabolic processGO:00092031080.012
organonitrogen compound catabolic processGO:19015651280.012
negative regulation of developmental growthGO:0048640640.012
negative regulation of cell deathGO:0060548810.012
Mouse
cell cell adhesionGO:0098609260.012
organelle fissionGO:00482853400.012
regulation of immune system processGO:00026821760.012
single organism behaviorGO:00447083910.012
striated muscle adaptationGO:001488810.012
regulation of secretionGO:0051046440.012
regulation of ion transportGO:0043269390.012
macromolecule catabolic processGO:00090571610.012
positive regulation of secretion by cellGO:1903532200.012
eye photoreceptor cell differentiationGO:00017541450.012
skeletal muscle adaptationGO:004350110.012
regulation of neurotransmitter levelsGO:0001505380.012
nucleoside triphosphate catabolic processGO:00091431080.012
regulation of endocytosisGO:0030100370.011
purine ribonucleotide catabolic processGO:00091541090.011
cell cycle arrestGO:000705040.011
negative regulation of protein polymerizationGO:003227270.011
cation transportGO:00068121100.011
purine nucleotide metabolic processGO:00061631460.011
negative regulation of protein modification processGO:0031400290.011
Mouse
nucleoside phosphate metabolic processGO:00067531620.011
intracellular protein transportGO:00068861040.011
negative regulation of neuron apoptotic processGO:0043524140.011
negative regulation of microtubule polymerization or depolymerizationGO:0031111210.011
atp metabolic processGO:0046034490.011
neuron apoptotic processGO:0051402170.011
regulation of erbb signaling pathwayGO:1901184420.010
intraspecies interaction between organismsGO:005170340.010
regulation of phosphorylationGO:00423251470.010
Mouse
matingGO:00076181200.010
chromosome organizationGO:00512763600.010
negative regulation of neuron deathGO:1901215180.010
negative regulation of epithelial cell migrationGO:001063310.010
compound eye photoreceptor cell differentiationGO:00017511400.010
cytosolic calcium ion transportGO:006040120.010
mitotic nuclear divisionGO:00070672130.010
positive regulation of cellular catabolic processGO:0031331950.010
atp catabolic processGO:0006200380.010

Mical disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.081
musculoskeletal system diseaseDOID:1700.035
disease of cellular proliferationDOID:1456600.027
cancerDOID:16200.027
cardiovascular system diseaseDOID:128700.026
organ system cancerDOID:005068600.017
nervous system diseaseDOID:86300.017
eye and adnexa diseaseDOID:149200.016
sensory system diseaseDOID:005015500.016
muscular diseaseDOID:008000000.015
myopathyDOID:42300.015
muscle tissue diseaseDOID:6600.015