IMP: Integrative Multi-species Prediction

Drosophila melanogaster

78 known processes

frc (Dmel_CG3874)

fringe connection

(Aliases: FRC,dFRC,l(3)S070006,UST74C,Dmel\CG3874,UDP-GlcNAc/UDP-GlcUA,anon-WO0172774.5,anon-WO0172774.7,l(3)10098,ust74C,l(3)L6750,CG3874,l(3)00073,l(3)j2E3,l(3)02619)

FLYBASE: FBgn0042641
Entrez: 39943
UniProtKB: B7Z066
UniProtKB: Q95YI5

Process Predictions
Disease Predictions

frc biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
embryonic morphogenesis	GO:0048598	206	0.973
tube development	GO:0035295	244	0.947
eye development	GO:0001654	323	0.884
compound eye development	GO:0048749	307	0.883
imaginal disc derived wing hair organization	GO:0035317	45	0.866
tissue morphogenesis	GO:0048729	297	0.846	Worm
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.836
morphogenesis of a polarized epithelium	GO:0001738	93	0.819
digestive system development	GO:0055123	149	0.815
axon guidance	GO:0007411	233	0.795
tube morphogenesis	GO:0035239	191	0.782
digestive tract development	GO:0048565	149	0.751
formation of primary germ layer	GO:0001704	24	0.737
gastrulation	GO:0007369	70	0.730
establishment of tissue polarity	GO:0007164	87	0.724
regionalization	GO:0003002	416	0.719
cell motility	GO:0048870	251	0.700
taxis	GO:0042330	304	0.685
cell junction assembly	GO:0034329	42	0.661
imaginal disc derived wing morphogenesis	GO:0007476	337	0.647
wing disc morphogenesis	GO:0007472	344	0.592
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.587
sensory organ morphogenesis	GO:0090596	260	0.561
regulation of cell proliferation	GO:0042127	163	0.554
non sensory hair organization	GO:0035316	47	0.529
sensory perception	GO:0007600	196	0.514
embryonic development via the syncytial blastoderm	GO:0001700	148	0.504
sensory perception of sound	GO:0007605	56	0.485
embryo development ending in birth or egg hatching	GO:0009792	152	0.484	Mouse Worm
establishment of planar polarity	GO:0001736	87	0.478
cell migration	GO:0016477	238	0.471
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.459
sensory perception of mechanical stimulus	GO:0050954	72	0.453
establishment or maintenance of apical basal cell polarity	GO:0035088	34	0.453
mesoderm development	GO:0007498	78	0.417
appendage morphogenesis	GO:0035107	397	0.411
establishment of imaginal disc derived wing hair orientation	GO:0001737	24	0.395
establishment or maintenance of bipolar cell polarity	GO:0061245	34	0.390
carbohydrate derivative metabolic process	GO:1901135	217	0.387	Mouse
imaginal disc derived leg morphogenesis	GO:0007480	80	0.365
single organism cellular localization	GO:1902580	180	0.364
regulation of multicellular organismal development	GO:2000026	414	0.351
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.346
regulation of cell cycle	GO:0051726	291	0.335
transcription from rna polymerase ii promoter	GO:0006366	368	0.332
eye morphogenesis	GO:0048592	260	0.325
protein modification process	GO:0036211	438	0.325
regulation of cellular catabolic process	GO:0031329	157	0.324
positive regulation of rna metabolic process	GO:0051254	271	0.324
respiratory system development	GO:0060541	213	0.323
regulation of anatomical structure morphogenesis	GO:0022603	242	0.322
cell death	GO:0008219	279	0.295
cell proliferation	GO:0008283	299	0.294
digestive tract morphogenesis	GO:0048546	127	0.294
establishment of localization in cell	GO:0051649	402	0.291
developmental pigmentation	GO:0048066	68	0.287
compound eye morphogenesis	GO:0001745	249	0.286
positive regulation of transcription dna templated	GO:0045893	266	0.281
forebrain development	GO:0030900	2	0.275
appendage development	GO:0048736	401	0.273
mesoderm morphogenesis	GO:0048332	22	0.271
multi organism behavior	GO:0051705	175	0.269	Worm
head development	GO:0060322	135	0.266
cellular protein localization	GO:0034613	160	0.266
axon development	GO:0061564	297	0.255
localization of cell	GO:0051674	257	0.254
hair cell differentiation	GO:0035315	47	0.247
embryonic organ development	GO:0048568	50	0.247
periodic partitioning	GO:0007365	29	0.246
imaginal disc derived appendage development	GO:0048737	399	0.244
larval development	GO:0002164	104	0.243	Worm
positive regulation of rna biosynthetic process	GO:1902680	266	0.240
regulation of molecular function	GO:0065009	217	0.237
neurological system process	GO:0050877	358	0.237
small molecule metabolic process	GO:0044281	305	0.236	Mouse
asymmetric protein localization involved in cell fate determination	GO:0045167	9	0.224
chemotaxis	GO:0006935	249	0.221
central nervous system development	GO:0007417	201	0.221
cellular polysaccharide metabolic process	GO:0044264	11	0.219
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.212
intracellular signal transduction	GO:0035556	300	0.211
glycosyl compound metabolic process	GO:1901657	127	0.209
nuclear division	GO:0000280	332	0.193
mesoderm formation	GO:0001707	21	0.193
organonitrogen compound metabolic process	GO:1901564	318	0.192	Mouse
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.189
gastrulation with mouth forming first	GO:0001703	36	0.185
body morphogenesis	GO:0010171	2	0.179
blastoderm segmentation	GO:0007350	159	0.176
nucleoside phosphate catabolic process	GO:1901292	110	0.174
anterior posterior pattern specification	GO:0009952	136	0.173
regulation of cytoskeleton organization	GO:0051493	89	0.173
ras protein signal transduction	GO:0007265	88	0.168
open tracheal system development	GO:0007424	204	0.168
regulation of catabolic process	GO:0009894	170	0.165
neuron projection guidance	GO:0097485	241	0.165
regulation of neurogenesis	GO:0050767	158	0.164
imaginal disc derived wing vein morphogenesis	GO:0008586	44	0.164
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.161
ameboidal type cell migration	GO:0001667	151	0.161
cellular catabolic process	GO:0044248	372	0.161
epithelial cell differentiation	GO:0030855	322	0.161
segmentation	GO:0035282	207	0.157
single organism behavior	GO:0044708	391	0.156
organic substance catabolic process	GO:1901575	308	0.156
endocytosis	GO:0006897	310	0.155
non canonical wnt signaling pathway	GO:0035567	8	0.155
reproductive structure development	GO:0048608	74	0.152
ion transmembrane transport	GO:0034220	122	0.149
catabolic process	GO:0009056	409	0.147
positive regulation of phosphate metabolic process	GO:0045937	139	0.146
protein localization	GO:0008104	284	0.146
protein targeting	GO:0006605	64	0.145
establishment of protein localization	GO:0045184	163	0.144
cell migration involved in gastrulation	GO:0042074	9	0.142
cellular macromolecule localization	GO:0070727	220	0.138
oxoacid metabolic process	GO:0043436	103	0.133	Mouse
establishment or maintenance of monopolar cell polarity	GO:0061339	15	0.132
compound eye photoreceptor cell differentiation	GO:0001751	140	0.130
embryonic pattern specification	GO:0009880	174	0.130
axonogenesis	GO:0007409	290	0.127
response to growth factor	GO:0070848	31	0.126
regulation of phosphate metabolic process	GO:0019220	210	0.126
regulation of protein localization	GO:0032880	76	0.122
intracellular protein transport	GO:0006886	104	0.121
regulation of protein modification process	GO:0031399	112	0.121
establishment or maintenance of epithelial cell apical basal polarity	GO:0045197	24	0.118
organic substance transport	GO:0071702	257	0.118
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.114
imaginal disc derived wing margin morphogenesis	GO:0008587	41	0.114
synaptic transmission	GO:0007268	288	0.113
morphogenesis of an epithelium	GO:0002009	276	0.113	Worm
regulation of ras protein signal transduction	GO:0046578	93	0.113
regulation of programmed cell death	GO:0043067	152	0.113
response to oxygen containing compound	GO:1901700	200	0.112
neuromuscular junction development	GO:0007528	149	0.112
response to organic substance	GO:0010033	284	0.111
post embryonic appendage morphogenesis	GO:0035120	385	0.111
leg disc morphogenesis	GO:0007478	80	0.111
regulation of microtubule based process	GO:0032886	49	0.111
epithelial cell migration	GO:0010631	148	0.110
mesodermal cell migration	GO:0008078	7	0.109
establishment of monopolar cell polarity	GO:0061162	15	0.107
positive regulation of nucleoside metabolic process	GO:0045979	47	0.106
establishment of organelle localization	GO:0051656	122	0.105
positive regulation of catalytic activity	GO:0043085	118	0.105
cellular protein modification process	GO:0006464	438	0.105
camera type eye morphogenesis	GO:0048593	2	0.105
establishment or maintenance of cell polarity	GO:0007163	167	0.104
developmental growth	GO:0048589	280	0.104
axis specification	GO:0009798	167	0.102
regulation of localization	GO:0032879	275	0.102
purine nucleoside catabolic process	GO:0006152	112	0.102
positive regulation of gtp catabolic process	GO:0033126	43	0.101
guanosine containing compound catabolic process	GO:1901069	74	0.101
cellular response to dna damage stimulus	GO:0006974	223	0.101
developmental maturation	GO:0021700	172	0.101
single organism membrane organization	GO:0044802	93	0.100
peripheral nervous system development	GO:0007422	52	0.100
regulation of nervous system development	GO:0051960	248	0.097
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.097
developmental programmed cell death	GO:0010623	138	0.097
sex differentiation	GO:0007548	81	0.096
regulation of epithelial cell proliferation	GO:0050678	4	0.095
cell division	GO:0051301	248	0.094
regulation of organ morphogenesis	GO:2000027	78	0.093
retina development in camera type eye	GO:0060041	4	0.093
leg disc development	GO:0035218	92	0.092
reproductive system development	GO:0061458	74	0.092
chondroitin sulfate metabolic process	GO:0030204	2	0.092	Mouse
embryonic digestive tract development	GO:0048566	5	0.091
positive regulation of molecular function	GO:0044093	136	0.091
establishment of protein localization to organelle	GO:0072594	62	0.090
single organism nuclear import	GO:1902593	51	0.090
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	41	0.089
camera type eye development	GO:0043010	4	0.088
imaginal disc derived leg joint morphogenesis	GO:0016348	15	0.088
single organism catabolic process	GO:0044712	228	0.088
establishment of epithelial cell apical basal polarity	GO:0045198	10	0.087
dorsal closure	GO:0007391	79	0.086
glycosyl compound catabolic process	GO:1901658	112	0.086
response to endogenous stimulus	GO:0009719	119	0.085
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.084
cellular response to fibroblast growth factor stimulus	GO:0044344	10	0.084
neural precursor cell proliferation	GO:0061351	75	0.084
response to fibroblast growth factor	GO:0071774	10	0.083
epidermal cell differentiation	GO:0009913	51	0.083
negative regulation of cell cycle	GO:0045786	116	0.082
ribonucleotide metabolic process	GO:0009259	145	0.082
endoderm formation	GO:0001706	3	0.080
adult behavior	GO:0030534	137	0.080
notch signaling pathway	GO:0007219	120	0.080
positive regulation of cellular catabolic process	GO:0031331	95	0.080
regulation of phosphorus metabolic process	GO:0051174	210	0.080
positive regulation of nucleotide catabolic process	GO:0030813	46	0.079
protein transport	GO:0015031	155	0.079
germ band extension	GO:0007377	11	0.079
dorsal ventral pattern formation	GO:0009953	133	0.078
regulation of developmental pigmentation	GO:0048070	24	0.077
regulation of cell development	GO:0060284	215	0.076
glial cell differentiation	GO:0010001	35	0.076
lipid metabolic process	GO:0006629	121	0.076
regulation of apoptotic signaling pathway	GO:2001233	10	0.076
nucleoside metabolic process	GO:0009116	127	0.075
brain development	GO:0007420	120	0.075
heparan sulfate proteoglycan biosynthetic process polysaccharide chain biosynthetic process	GO:0015014	5	0.074
positive regulation of cellular component organization	GO:0051130	156	0.074
imaginal disc derived wing vein specification	GO:0007474	48	0.073
purine ribonucleoside metabolic process	GO:0046128	127	0.073
epithelial tube morphogenesis	GO:0060562	88	0.073
ion transport	GO:0006811	145	0.073
asymmetric stem cell division	GO:0098722	49	0.073
nucleobase containing compound catabolic process	GO:0034655	165	0.072
kidney development	GO:0001822	3	0.072
skin development	GO:0043588	65	0.072
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.072
mesenchymal cell differentiation	GO:0048762	1	0.071
establishment of ommatidial planar polarity	GO:0042067	49	0.071
cell maturation	GO:0048469	144	0.071
guanosine containing compound metabolic process	GO:1901068	74	0.071
lipid localization	GO:0010876	54	0.069
regulation of cell shape	GO:0008360	113	0.068
compound eye photoreceptor fate commitment	GO:0001752	36	0.068
organonitrogen compound catabolic process	GO:1901565	128	0.068
endodermal cell fate commitment	GO:0001711	3	0.067
negative regulation of biosynthetic process	GO:0009890	277	0.065
cuticle development	GO:0042335	86	0.065
maintenance of apical basal cell polarity	GO:0035090	8	0.064
nuclear import	GO:0051170	51	0.064
gastrulation involving germ band extension	GO:0010004	36	0.064
carbohydrate derivative catabolic process	GO:1901136	118	0.063
negative regulation of response to stimulus	GO:0048585	258	0.063
embryonic digestive tract morphogenesis	GO:0048557	4	0.063
positive regulation of purine nucleotide metabolic process	GO:1900544	55	0.062
negative regulation of epithelial cell proliferation	GO:0050680	4	0.062
vesicle mediated transport	GO:0016192	381	0.061
wnt signaling pathway	GO:0016055	98	0.061
retina morphogenesis in camera type eye	GO:0060042	2	0.061
regulation of cell division	GO:0051302	72	0.061
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.060
growth	GO:0040007	359	0.059
nucleotide metabolic process	GO:0009117	161	0.059
glycoprotein metabolic process	GO:0009100	41	0.059	Mouse
cellular response to organic substance	GO:0071310	132	0.059
purine containing compound metabolic process	GO:0072521	155	0.058
positive regulation of developmental process	GO:0051094	143	0.058
regulation of microtubule cytoskeleton organization	GO:0070507	41	0.058
neuroblast proliferation	GO:0007405	74	0.057
cellular response to growth factor stimulus	GO:0071363	30	0.056
programmed cell death	GO:0012501	257	0.056
response to abiotic stimulus	GO:0009628	341	0.056
mitotic nuclear division	GO:0007067	213	0.055
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.055
regulation of nucleotide catabolic process	GO:0030811	48	0.055
regulation of establishment of planar polarity	GO:0090175	22	0.055
establishment or maintenance of cytoskeleton polarity	GO:0030952	44	0.055
negative regulation of rna metabolic process	GO:0051253	251	0.054
plasma membrane organization	GO:0007009	26	0.054
apoptotic process	GO:0006915	159	0.053
response to radiation	GO:0009314	155	0.053
cellular lipid metabolic process	GO:0044255	83	0.053
embryonic foregut morphogenesis	GO:0048617	3	0.052
positive regulation of phosphorus metabolic process	GO:0010562	139	0.052
stem cell differentiation	GO:0048863	117	0.052
positive regulation of cell development	GO:0010720	61	0.051
ribonucleoside catabolic process	GO:0042454	112	0.050
cell junction organization	GO:0034330	57	0.050
positive regulation of protein metabolic process	GO:0051247	128	0.049
gtp catabolic process	GO:0006184	72	0.049
regulation of muscle organ development	GO:0048634	13	0.049
regulation of cellular localization	GO:0060341	136	0.049
cardiovascular system development	GO:0072358	82	0.048
positive regulation of response to stimulus	GO:0048584	323	0.048
regulation of cell death	GO:0010941	173	0.048
small gtpase mediated signal transduction	GO:0007264	88	0.048
protein localization to nucleus	GO:0034504	55	0.048
regulation of intracellular signal transduction	GO:1902531	236	0.047
protein import	GO:0017038	55	0.047
positive regulation of cellular biosynthetic process	GO:0031328	316	0.046
regulation of notch signaling pathway	GO:0008593	100	0.046
pigmentation	GO:0043473	75	0.046
mushroom body development	GO:0016319	70	0.045
regulation of transport	GO:0051049	181	0.045
cell growth	GO:0016049	108	0.045
epithelial cell morphogenesis	GO:0003382	25	0.045
gliogenesis	GO:0042063	80	0.045
chitin based cuticle development	GO:0040003	49	0.044
centrosome organization	GO:0051297	163	0.044
oocyte construction	GO:0007308	112	0.044
epithelial cell development	GO:0002064	274	0.044
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.044
regulation of cell differentiation	GO:0045595	302	0.043
intracellular transport	GO:0046907	228	0.043
epithelial cell proliferation	GO:0050673	15	0.043
epidermis development	GO:0008544	65	0.043
apical constriction	GO:0003383	18	0.043
negative regulation of notch signaling pathway	GO:0045746	41	0.042
cellular response to chemical stimulus	GO:0070887	199	0.042
protein import into nucleus	GO:0006606	51	0.042
apical constriction involved in gastrulation	GO:0003384	7	0.042
nucleoside triphosphate catabolic process	GO:0009143	108	0.042
ribonucleotide catabolic process	GO:0009261	109	0.042
muscle structure development	GO:0061061	224	0.041
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.041
photoreceptor cell fate commitment	GO:0046552	41	0.041
telencephalon development	GO:0021537	2	0.041
cellular amine metabolic process	GO:0044106	12	0.041
establishment of spindle localization	GO:0051293	22	0.041
negative regulation of growth	GO:0045926	84	0.040
neuron fate commitment	GO:0048663	50	0.040
immune system process	GO:0002376	347	0.040
negative regulation of cellular metabolic process	GO:0031324	382	0.040
regulation of apoptotic process	GO:0042981	130	0.040
gonad development	GO:0008406	50	0.040
single organismal cell cell adhesion	GO:0016337	45	0.039
microtubule cytoskeleton organization involved in mitosis	GO:1902850	52	0.039
establishment of cell polarity	GO:0030010	40	0.039
negative regulation of multicellular organismal process	GO:0051241	142	0.039
multi organism reproductive behavior	GO:0044705	121	0.039	Worm
mesenchymal cell development	GO:0014031	1	0.038
eye photoreceptor cell fate commitment	GO:0042706	37	0.038
cellular nitrogen compound catabolic process	GO:0044270	165	0.038
regulation of protein transport	GO:0051223	57	0.038
regulation of cellular response to stress	GO:0080135	89	0.038
maintenance of cell polarity	GO:0030011	18	0.038
nucleotide catabolic process	GO:0009166	109	0.038
cardioblast cell fate specification	GO:0042685	9	0.038
development of primary sexual characteristics	GO:0045137	50	0.037
negative regulation of developmental process	GO:0051093	201	0.037
regulation of cell morphogenesis	GO:0022604	163	0.037
cell fate specification	GO:0001708	71	0.037
positive regulation of hydrolase activity	GO:0051345	78	0.037
cytoplasmic transport	GO:0016482	130	0.037
negative regulation of programmed cell death	GO:0043069	72	0.037
trachea development	GO:0060438	29	0.036
glycoprotein biosynthetic process	GO:0009101	41	0.036	Mouse
regulation of establishment of protein localization	GO:0070201	61	0.036
purine ribonucleoside catabolic process	GO:0046130	112	0.036
cation transport	GO:0006812	110	0.036
regulation of intracellular transport	GO:0032386	64	0.035
amine metabolic process	GO:0009308	12	0.035
regulation of embryonic development	GO:0045995	68	0.035
phosphorylation	GO:0016310	294	0.035
endodermal cell differentiation	GO:0035987	3	0.035
regulation of organelle organization	GO:0033043	196	0.035
nucleoside triphosphate metabolic process	GO:0009141	120	0.034
nucleobase containing small molecule metabolic process	GO:0055086	174	0.034
imaginal disc pattern formation	GO:0007447	91	0.034
protein targeting to nucleus	GO:0044744	51	0.034
regulation of intracellular protein transport	GO:0033157	46	0.034
spindle organization	GO:0007051	253	0.033
imaginal disc derived leg segmentation	GO:0036011	26	0.033
actin cytoskeleton organization	GO:0030036	206	0.033
proteasomal protein catabolic process	GO:0010498	59	0.033
positive regulation of nucleotide metabolic process	GO:0045981	55	0.033
immune system development	GO:0002520	57	0.033
regulation of mitotic cell cycle	GO:0007346	190	0.033
carbohydrate derivative biosynthetic process	GO:1901137	85	0.032	Mouse
septate junction assembly	GO:0019991	26	0.032
ribonucleoside metabolic process	GO:0009119	127	0.032
nucleocytoplasmic transport	GO:0006913	72	0.031
cellular amino acid metabolic process	GO:0006520	61	0.031
regulation of catalytic activity	GO:0050790	185	0.031
cell adhesion	GO:0007155	136	0.031
male gonad development	GO:0008584	9	0.031
positive regulation of gtpase activity	GO:0043547	43	0.031
histone modification	GO:0016570	106	0.030
purine nucleotide catabolic process	GO:0006195	109	0.030
glial cell development	GO:0021782	27	0.030
cellular response to endogenous stimulus	GO:0071495	80	0.030
regulation of membrane potential	GO:0042391	35	0.030
actin filament based process	GO:0030029	220	0.029
negative regulation of rna biosynthetic process	GO:1902679	240	0.029
extracellular matrix organization	GO:0030198	32	0.029
unidimensional cell growth	GO:0009826	15	0.029
endomembrane system organization	GO:0010256	119	0.029
establishment or maintenance of polarity of follicular epithelium	GO:0016334	26	0.029
muscle organ development	GO:0007517	127	0.029
limb development	GO:0060173	1	0.028
gtp metabolic process	GO:0046039	72	0.028
cell cell junction organization	GO:0045216	55	0.028
hematopoietic or lymphoid organ development	GO:0048534	57	0.028
cell elongation involved in imaginal disc derived wing morphogenesis	GO:0090254	5	0.028
positive regulation of protein transport	GO:0051222	37	0.028
stem cell division	GO:0017145	69	0.028
positive regulation of purine nucleotide catabolic process	GO:0033123	46	0.028
developmental growth involved in morphogenesis	GO:0060560	65	0.028
fibroblast growth factor receptor signaling pathway	GO:0008543	10	0.027
regulation of ras gtpase activity	GO:0032318	38	0.027
synapse assembly	GO:0007416	143	0.027
synaptic growth at neuromuscular junction	GO:0051124	119	0.027
regulation of cellular protein metabolic process	GO:0032268	243	0.027
organophosphate biosynthetic process	GO:0090407	46	0.027
male gamete generation	GO:0048232	201	0.027
regulation of cell cycle process	GO:0010564	181	0.026
dorsal ventral axis specification	GO:0009950	66	0.026
establishment of mitotic spindle localization	GO:0040001	17	0.026
positive regulation of signaling	GO:0023056	243	0.026
convergent extension	GO:0060026	2	0.026
wing disc pattern formation	GO:0035222	66	0.026
sulfur compound metabolic process	GO:0006790	59	0.026	Mouse
positive regulation of transport	GO:0051050	92	0.026
negative regulation of cellular component organization	GO:0051129	108	0.026
regulation of cellular amine metabolic process	GO:0033238	3	0.026
purine ribonucleotide catabolic process	GO:0009154	109	0.026
cuticle pattern formation	GO:0035017	27	0.026
macromolecule catabolic process	GO:0009057	161	0.025
regulation of kinase activity	GO:0043549	53	0.025
negative regulation of synaptic growth at neuromuscular junction	GO:0045886	39	0.025
positive regulation of cell differentiation	GO:0045597	64	0.025
positive regulation of protein modification process	GO:0031401	58	0.025
nucleoside catabolic process	GO:0009164	112	0.025
establishment of protein localization to plasma membrane	GO:0090002	9	0.025
morphogenesis of follicular epithelium	GO:0016333	36	0.025
death	GO:0016265	284	0.025
actin filament based movement	GO:0030048	26	0.025
positive regulation of multicellular organismal process	GO:0051240	143	0.024
purine nucleotide metabolic process	GO:0006163	146	0.024
salivary gland development	GO:0007431	162	0.024
gland morphogenesis	GO:0022612	145	0.024
gland development	GO:0048732	191	0.024
circulatory system development	GO:0072359	82	0.024
determination of dorsal ventral asymmetry	GO:0048262	3	0.024
oocyte differentiation	GO:0009994	145	0.024
positive regulation of nervous system development	GO:0051962	69	0.024
regulation of phosphorylation	GO:0042325	147	0.024
nucleoside phosphate metabolic process	GO:0006753	162	0.024
germ cell migration	GO:0008354	43	0.024
wnt signaling pathway planar cell polarity pathway	GO:0060071	6	0.023
exocrine system development	GO:0035272	162	0.023
tissue homeostasis	GO:0001894	36	0.023
organic hydroxy compound metabolic process	GO:1901615	83	0.023
positive regulation of catabolic process	GO:0009896	105	0.023
stem cell proliferation	GO:0072089	88	0.023
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.023
organic cyclic compound catabolic process	GO:1901361	168	0.023
heterocycle catabolic process	GO:0046700	166	0.023
oocyte axis specification	GO:0007309	108	0.023
establishment of protein localization to membrane	GO:0090150	11	0.022
epithelial cell migration open tracheal system	GO:0007427	32	0.022
chondroitin sulfate proteoglycan metabolic process	GO:0050654	3	0.022	Mouse
regulation of purine nucleotide metabolic process	GO:1900542	62	0.022
protein localization to organelle	GO:0033365	82	0.022
enteroendocrine cell differentiation	GO:0035883	1	0.022
renal system development	GO:0072001	72	0.022
organelle fission	GO:0048285	340	0.022
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.022
detection of external stimulus	GO:0009581	66	0.022
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.022
organophosphate catabolic process	GO:0046434	112	0.022
regulation of cell motility	GO:2000145	23	0.022
limb morphogenesis	GO:0035108	1	0.021
response to nitrogen compound	GO:1901698	90	0.021
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.021
phenol containing compound metabolic process	GO:0018958	57	0.021
epithelial cell cell adhesion	GO:0090136	6	0.021
protein localization to membrane	GO:0072657	19	0.021
mitotic spindle organization	GO:0007052	220	0.021
development of primary male sexual characteristics	GO:0046546	9	0.021
female gonad development	GO:0008585	12	0.021
inorganic cation transmembrane transport	GO:0098662	61	0.021
biological adhesion	GO:0022610	138	0.020
peptidyl tyrosine modification	GO:0018212	24	0.020
purine ribonucleotide metabolic process	GO:0009150	145	0.020
skeletal muscle organ development	GO:0060538	48	0.020
positive regulation of signal transduction	GO:0009967	223	0.020
ribose phosphate metabolic process	GO:0019693	145	0.020
cardioblast cell fate commitment	GO:0042684	14	0.020
positive regulation of ras gtpase activity	GO:0032320	36	0.020
instar larval development	GO:0002168	55	0.020
negative regulation of cell proliferation	GO:0008285	69	0.020
regulation of mapk cascade	GO:0043408	92	0.020
genitalia development	GO:0048806	26	0.020
neuronal stem cell division	GO:0036445	35	0.019
tissue migration	GO:0090130	155	0.019
photoreceptor cell differentiation	GO:0046530	170	0.019
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.019
smoothened signaling pathway	GO:0007224	49	0.019
cellular response to peptide	GO:1901653	28	0.019
embryonic heart tube development	GO:0035050	22	0.019
apical junction assembly	GO:0043297	32	0.019
cell proliferation involved in imaginal disc derived wing morphogenesis	GO:0090255	2	0.019
negative regulation of cell death	GO:0060548	81	0.019
negative regulation of protein metabolic process	GO:0051248	85	0.019
locomotory behavior	GO:0007626	176	0.019
positive regulation of gene expression	GO:0010628	290	0.018
intracellular mrna localization involved in anterior posterior axis specification	GO:0060811	53	0.018
protein phosphorylation	GO:0006468	169	0.018
negative regulation of cell fate commitment	GO:0010454	17	0.018
heart development	GO:0007507	82	0.018
convergent extension involved in gastrulation	GO:0060027	2	0.018

frc disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.097
cancer	DOID:162	0.041
disease of anatomical entity	DOID:7	0.035
organ system cancer	DOID:0050686	0.033
heart disease	DOID:114	0.020
tetralogy of fallot	DOID:6419	0.020
cardiovascular system disease	DOID:1287	0.020
congenital heart disease	DOID:1682	0.020

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