IMP: Integrative Multi-species Prediction

Drosophila melanogaster

180 known processes

Cul-4 (Dmel_CG8711)

Cullin-4

(Aliases: CG8711,DMcul-4,Cul4,CUL4,Dmel\CG8711,dCul4,cul-4)

Entrez: 35780
FLYBASE: FBgn0033260
UniProtKB: Q5BI50

Process Predictions
Disease Predictions

Cul-4 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
epithelial cell differentiation	GO:0030855	322	0.613
protein catabolic process	GO:0030163	101	0.559
macromolecule catabolic process	GO:0009057	161	0.462
cellular macromolecule catabolic process	GO:0044265	136	0.374	Mouse
regulation of catabolic process	GO:0009894	170	0.351
organelle fission	GO:0048285	340	0.318
protein modification by small protein conjugation or removal	GO:0070647	106	0.277	Human
protein ubiquitination	GO:0016567	70	0.233	Human
histone modification	GO:0016570	106	0.227	Human
ubiquitin dependent protein catabolic process	GO:0006511	78	0.208	Mouse
body morphogenesis	GO:0010171	2	0.201
cellular amino acid metabolic process	GO:0006520	61	0.183
cell cycle phase transition	GO:0044770	140	0.176
regulation of cellular ketone metabolic process	GO:0010565	3	0.174
positive regulation of catabolic process	GO:0009896	105	0.169
regulation of cell cycle process	GO:0010564	181	0.162
histone acetylation	GO:0016573	38	0.162
regulation of cellular amine metabolic process	GO:0033238	3	0.155
single organism cellular localization	GO:1902580	180	0.150
regulation of protein catabolic process	GO:0042176	55	0.140
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.138
organic substance catabolic process	GO:1901575	308	0.133
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.129	Mouse
transcription from rna polymerase ii promoter	GO:0006366	368	0.124
regulation of cellular amino acid metabolic process	GO:0006521	0	0.121
posttranscriptional gene silencing by rna	GO:0035194	45	0.116
male gamete generation	GO:0048232	201	0.115
covalent chromatin modification	GO:0016569	106	0.107	Human
regulation of cell cycle phase transition	GO:1901987	130	0.107
rna transport	GO:0050658	46	0.106
mitotic dna damage checkpoint	GO:0044773	74	0.104
cellular protein modification process	GO:0006464	438	0.096	Human
mrna metabolic process	GO:0016071	124	0.094
growth	GO:0040007	359	0.093
protein complex biogenesis	GO:0070271	201	0.087
positive regulation of protein metabolic process	GO:0051247	128	0.082
carboxylic acid metabolic process	GO:0019752	92	0.081
protein complex assembly	GO:0006461	200	0.077
spermatid differentiation	GO:0048515	114	0.074
cell proliferation	GO:0008283	299	0.074	Mouse
chromatin remodeling	GO:0006338	72	0.072
nuclear transcribed mrna catabolic process deadenylation dependent decay	GO:0000288	14	0.071
amine metabolic process	GO:0009308	12	0.070
proteolysis	GO:0006508	192	0.069	Mouse
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.067
regulation of cellular protein metabolic process	GO:0032268	243	0.060
nucleobase containing compound transport	GO:0015931	56	0.060
posttranscriptional gene silencing	GO:0016441	46	0.059
regulation of protein metabolic process	GO:0051246	256	0.058
mrna catabolic process	GO:0006402	33	0.057
regulation of cell morphogenesis	GO:0022604	163	0.056
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.055
modification dependent protein catabolic process	GO:0019941	78	0.053	Mouse
posttranscriptional regulation of gene expression	GO:0010608	145	0.052
positive regulation of protein catabolic process	GO:0045732	34	0.052
spermatid development	GO:0007286	98	0.049
cellular macromolecular complex assembly	GO:0034622	153	0.046
positive regulation of cellular protein metabolic process	GO:0032270	118	0.045
positive regulation of macromolecule metabolic process	GO:0010604	405	0.045
modification dependent macromolecule catabolic process	GO:0043632	79	0.044	Mouse
cellular amine metabolic process	GO:0044106	12	0.044
chromosome organization	GO:0051276	360	0.044	Human
regulation of cell shape	GO:0008360	113	0.043
catabolic process	GO:0009056	409	0.043
protein modification process	GO:0036211	438	0.042	Human
ovarian follicle cell development	GO:0030707	248	0.041
regionalization	GO:0003002	416	0.040
rna localization	GO:0006403	115	0.040
cellular protein complex assembly	GO:0043623	71	0.040
protein modification by small protein conjugation	GO:0032446	79	0.038	Human
embryo development ending in birth or egg hatching	GO:0009792	152	0.037
negative regulation of response to stimulus	GO:0048585	258	0.036
columnar cuboidal epithelial cell development	GO:0002066	249	0.036
regulation of mitotic cell cycle	GO:0007346	190	0.036
positive regulation of signal transduction	GO:0009967	223	0.036
organic acid metabolic process	GO:0006082	103	0.035
regulation of catalytic activity	GO:0050790	185	0.034
cellular ketone metabolic process	GO:0042180	24	0.034
regulation of growth	GO:0040008	233	0.033
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.032
establishment of rna localization	GO:0051236	47	0.032
spermatogenesis	GO:0007283	200	0.032
dna templated transcription initiation	GO:0006352	25	0.031
vesicle mediated transport	GO:0016192	381	0.031
oxoacid metabolic process	GO:0043436	103	0.030
negative regulation of mitotic cell cycle	GO:0045930	109	0.029
chaeta development	GO:0022416	97	0.029
regulation of organelle organization	GO:0033043	196	0.027
positive regulation of cellular catabolic process	GO:0031331	95	0.027
peptidyl amino acid modification	GO:0018193	105	0.027
ribonucleoprotein complex biogenesis	GO:0022613	31	0.027
aging	GO:0007568	143	0.026
small molecule metabolic process	GO:0044281	305	0.026
protein targeting to nucleus	GO:0044744	51	0.025
organic substance transport	GO:0071702	257	0.025
single organism intracellular transport	GO:1902582	207	0.024
regulation of cell development	GO:0060284	215	0.024
gene silencing by rna	GO:0031047	57	0.024
regulation of cellular catabolic process	GO:0031329	157	0.023
proteasomal protein catabolic process	GO:0010498	59	0.023	Mouse
gliogenesis	GO:0042063	80	0.022
regulation of nervous system development	GO:0051960	248	0.022
cellular cation homeostasis	GO:0030003	38	0.022
peptidyl threonine phosphorylation	GO:0018107	2	0.022
regulation of intracellular signal transduction	GO:1902531	236	0.022
positive regulation of cellular amine metabolic process	GO:0033240	0	0.022
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.021
heterocycle catabolic process	GO:0046700	166	0.021
nucleobase containing compound catabolic process	GO:0034655	165	0.021
positive regulation of signaling	GO:0023056	243	0.021
protein acetylation	GO:0006473	39	0.021
nuclear transcribed mrna catabolic process	GO:0000956	24	0.021
transcription initiation from rna polymerase ii promoter	GO:0006367	25	0.020
nucleocytoplasmic transport	GO:0006913	72	0.020
imaginal disc pattern formation	GO:0007447	91	0.020
positive regulation of cell communication	GO:0010647	250	0.020
histone h2a acetylation	GO:0043968	1	0.020
rna interference	GO:0016246	27	0.020
mitotic nuclear division	GO:0007067	213	0.020
cell growth	GO:0016049	108	0.020
response to external biotic stimulus	GO:0043207	293	0.020
regulation of protein complex assembly	GO:0043254	42	0.019
wnt signaling pathway	GO:0016055	98	0.019
reproductive structure development	GO:0048608	74	0.018
single organism biosynthetic process	GO:0044711	206	0.018
anterior posterior axis specification	GO:0009948	109	0.018
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.018
protein localization to organelle	GO:0033365	82	0.018
regulation of translation	GO:0006417	56	0.018
translation	GO:0006412	69	0.018
cytoplasmic transport	GO:0016482	130	0.017
regulation of protein modification process	GO:0031399	112	0.017
g protein coupled receptor signaling pathway	GO:0007186	136	0.017
positive regulation of response to stimulus	GO:0048584	323	0.017
regulation of proteolysis	GO:0030162	87	0.017
stem cell differentiation	GO:0048863	117	0.017	Mouse
meiotic cell cycle	GO:0051321	171	0.017
nuclear export	GO:0051168	24	0.017
adherens junction organization	GO:0034332	27	0.017
negative regulation of protein metabolic process	GO:0051248	85	0.016
cellular catabolic process	GO:0044248	372	0.016	Mouse
positive regulation of cellular component organization	GO:0051130	156	0.016
cell fate determination	GO:0001709	91	0.016
negative regulation of growth	GO:0045926	84	0.016
regulation of cellular component biogenesis	GO:0044087	201	0.016
response to hypoxia	GO:0001666	53	0.016
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.016
autophagic cell death	GO:0048102	83	0.015
response to lipopolysaccharide	GO:0032496	4	0.015
protein modification by small protein removal	GO:0070646	28	0.015
response to radiation	GO:0009314	155	0.015	Human
positive regulation of proteolysis	GO:0045862	52	0.015
regulation of wnt signaling pathway	GO:0030111	68	0.015
macromolecular complex assembly	GO:0065003	256	0.015
regulation of hydrolase activity	GO:0051336	97	0.015
regulation of cell cycle	GO:0051726	291	0.014
organonitrogen compound metabolic process	GO:1901564	318	0.014
regulation of mrna 3 end processing	GO:0031440	7	0.014
sex differentiation	GO:0007548	81	0.014
organelle inheritance	GO:0048308	2	0.014
negative regulation of developmental process	GO:0051093	201	0.013	Mouse
endocytosis	GO:0006897	310	0.013
purine ribonucleotide catabolic process	GO:0009154	109	0.013
protein localization to nucleus	GO:0034504	55	0.013
nucleic acid transport	GO:0050657	46	0.013
cellular protein catabolic process	GO:0044257	83	0.013	Mouse
positive regulation of hydrolase activity	GO:0051345	78	0.013
regulation of protein phosphorylation	GO:0001932	64	0.013
hematopoietic progenitor cell differentiation	GO:0002244	1	0.013
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.013
larval development	GO:0002164	104	0.013
protein localization	GO:0008104	284	0.012
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.012
regulation of notch signaling pathway	GO:0008593	100	0.012
rna catabolic process	GO:0006401	37	0.012
positive regulation of protein modification process	GO:0031401	58	0.012
wound healing	GO:0042060	75	0.012
regulation of neurogenesis	GO:0050767	158	0.012
compound eye development	GO:0048749	307	0.012
negative regulation of cellular protein metabolic process	GO:0032269	85	0.012
defense response to other organism	GO:0098542	225	0.011
jak stat cascade	GO:0007259	49	0.011
protein transport	GO:0015031	155	0.011
nephron epithelium development	GO:0072009	3	0.011
response to other organism	GO:0051707	293	0.011
protein dna complex assembly	GO:0065004	63	0.011
protein import into nucleus	GO:0006606	51	0.011
rna processing	GO:0006396	147	0.011
chromatin modification	GO:0016568	147	0.011	Human
regulation of cellular protein catabolic process	GO:1903362	44	0.011
eggshell chorion gene amplification	GO:0007307	9	0.010
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.010
formation of a compartment boundary	GO:0060288	4	0.010
meiotic nuclear division	GO:0007126	151	0.010
dsrna fragmentation	GO:0031050	15	0.010
phosphorylation	GO:0016310	294	0.010
phagocytosis	GO:0006909	215	0.010
mitotic cell cycle phase transition	GO:0044772	138	0.010
internal peptidyl lysine acetylation	GO:0018393	38	0.010

Cul-4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.034
	disease of cellular proliferation	DOID:14566	0	0.011

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