IMP: Integrative Multi-species Prediction

Drosophila melanogaster

47 known processes

AnnIX (Dmel_CG5730)

Annexin IX

(Aliases: Anx B9,AnxB9,annexin,Ann,CG5730,Dmel\CG5730)

Entrez: 42492
FLYBASE: FBgn0000083
UniProtKB: P22464

Process Predictions
Disease Predictions

AnnIX biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
cellular response to light stimulus	GO:0071482	37	0.174
cellular response to high light intensity	GO:0071486	1	0.130
actin filament organization	GO:0007015	126	0.126
cell proliferation	GO:0008283	299	0.111	Mouse
regulation of anatomical structure morphogenesis	GO:0022603	242	0.100	Mouse Fly
response to abiotic stimulus	GO:0009628	341	0.098	Mouse
vesicle mediated transport	GO:0016192	381	0.093
regulation of cell death	GO:0010941	173	0.089
response to high light intensity	GO:0009644	1	0.086
dorsal ventral pattern formation	GO:0009953	133	0.085
immune system process	GO:0002376	347	0.082
cellular response to abiotic stimulus	GO:0071214	58	0.081
cell adhesion	GO:0007155	136	0.074	Fly
regulation of multicellular organismal development	GO:2000026	414	0.070
biological adhesion	GO:0022610	138	0.067	Fly
endocytosis	GO:0006897	310	0.066
cell motility	GO:0048870	251	0.060
growth	GO:0040007	359	0.060
positive regulation of biosynthetic process	GO:0009891	316	0.060
regulation of cell differentiation	GO:0045595	302	0.057
negative regulation of cellular metabolic process	GO:0031324	382	0.055
peptide metabolic process	GO:0006518	80	0.052
regulation of protein metabolic process	GO:0051246	256	0.051
establishment or maintenance of cell polarity	GO:0007163	167	0.049
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.047
multicellular organismal aging	GO:0010259	140	0.046
positive regulation of rna metabolic process	GO:0051254	271	0.046
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.045
aging	GO:0007568	143	0.045
regulation of cell morphogenesis	GO:0022604	163	0.044	Mouse Fly
negative regulation of gene expression	GO:0010629	387	0.043
positive regulation of cellular biosynthetic process	GO:0031328	316	0.043
regulation of cell proliferation	GO:0042127	163	0.042
body morphogenesis	GO:0010171	2	0.041
positive regulation of transcription dna templated	GO:0045893	266	0.040
positive regulation of immune system process	GO:0002684	68	0.037
positive regulation of rna biosynthetic process	GO:1902680	266	0.036
cellular response to radiation	GO:0071478	52	0.036
transcription from rna polymerase ii promoter	GO:0006366	368	0.034
embryo development ending in birth or egg hatching	GO:0009792	152	0.033
actin cytoskeleton organization	GO:0030036	206	0.031
epithelial cell differentiation	GO:0030855	322	0.031
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.031
regulation of anatomical structure size	GO:0090066	163	0.030
determination of adult lifespan	GO:0008340	137	0.029
response to radiation	GO:0009314	155	0.028
developmental growth	GO:0048589	280	0.028
regulation of cell shape	GO:0008360	113	0.027	Mouse Fly
glycosyl compound metabolic process	GO:1901657	127	0.027
regionalization	GO:0003002	416	0.027
regulation of immune system process	GO:0002682	176	0.027
immune effector process	GO:0002252	98	0.026
protein localization	GO:0008104	284	0.026
positive regulation of multicellular organismal process	GO:0051240	143	0.026
epithelial cell development	GO:0002064	274	0.026
regulation of cell development	GO:0060284	215	0.026
organonitrogen compound metabolic process	GO:1901564	318	0.025
centrosome organization	GO:0051297	163	0.025
regulation of catabolic process	GO:0009894	170	0.025
cellular amide metabolic process	GO:0043603	80	0.025
negative regulation of cell communication	GO:0010648	223	0.025
nucleoside metabolic process	GO:0009116	127	0.025
cellular response to light intensity	GO:0071484	1	0.025
negative regulation of cell differentiation	GO:0045596	143	0.025
kidney development	GO:0001822	3	0.024
immune response	GO:0006955	246	0.024
homeostatic process	GO:0042592	199	0.023	Mouse
phosphorylation	GO:0016310	294	0.023
negative regulation of molecular function	GO:0044092	51	0.023
regulation of cell cycle	GO:0051726	291	0.023
localization of cell	GO:0051674	257	0.023
regulation of wnt signaling pathway	GO:0030111	68	0.023
nucleoside triphosphate metabolic process	GO:0009141	120	0.022
regulation of cellular protein metabolic process	GO:0032268	243	0.022
positive regulation of cell communication	GO:0010647	250	0.022
regulation of phosphate metabolic process	GO:0019220	210	0.022
regulation of phosphorus metabolic process	GO:0051174	210	0.021
regulation of cellular catabolic process	GO:0031329	157	0.021
cellular component assembly involved in morphogenesis	GO:0010927	151	0.021
embryonic development via the syncytial blastoderm	GO:0001700	148	0.021
small gtpase mediated signal transduction	GO:0007264	88	0.021
negative regulation of signal transduction	GO:0009968	206	0.020
proteolysis	GO:0006508	192	0.020
tube morphogenesis	GO:0035239	191	0.020
dendrite morphogenesis	GO:0048813	199	0.020
response to organic substance	GO:0010033	284	0.020	Rat
dendrite development	GO:0016358	204	0.019
regulation of cell projection organization	GO:0031344	92	0.019
response to inorganic substance	GO:0010035	44	0.019	Rat
death	GO:0016265	284	0.019
positive regulation of developmental process	GO:0051094	143	0.019
eggshell formation	GO:0030703	105	0.019
purine ribonucleoside metabolic process	GO:0046128	127	0.018
negative regulation of response to stimulus	GO:0048585	258	0.018
ras protein signal transduction	GO:0007265	88	0.018
phagocytosis	GO:0006909	215	0.018
positive regulation of cell proliferation	GO:0008284	47	0.018
inter male aggressive behavior	GO:0002121	60	0.018
negative regulation of cell death	GO:0060548	81	0.018
oxoacid metabolic process	GO:0043436	103	0.018
purine containing compound metabolic process	GO:0072521	155	0.018
wnt signaling pathway	GO:0016055	98	0.018
eye development	GO:0001654	323	0.018
chromosome organization	GO:0051276	360	0.018
protein maturation	GO:0051604	71	0.018
intracellular signal transduction	GO:0035556	300	0.017
chorion containing eggshell formation	GO:0007304	105	0.017
regulation of cellular localization	GO:0060341	136	0.017
cellular protein localization	GO:0034613	160	0.017
ribose phosphate metabolic process	GO:0019693	145	0.017
single organism intracellular transport	GO:1902582	207	0.017
generation of precursor metabolites and energy	GO:0006091	42	0.017
nucleobase containing small molecule metabolic process	GO:0055086	174	0.017
lateral inhibition	GO:0046331	206	0.017
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.017
negative regulation of multicellular organismal process	GO:0051241	142	0.017
cellular amino acid metabolic process	GO:0006520	61	0.017
tube development	GO:0035295	244	0.017
organic substance transport	GO:0071702	257	0.016
positive regulation of hemocyte proliferation	GO:0035208	4	0.016
cell migration	GO:0016477	238	0.016
regulation of programmed cell death	GO:0043067	152	0.016
innate immune response	GO:0045087	144	0.016
regulation of molecular function	GO:0065009	217	0.016
regulation of phosphorylation	GO:0042325	147	0.016
response to wounding	GO:0009611	94	0.015
regulation of nucleotide metabolic process	GO:0006140	62	0.015
mitotic nuclear division	GO:0007067	213	0.015
negative regulation of developmental process	GO:0051093	201	0.015
carbohydrate derivative metabolic process	GO:1901135	217	0.015
protein processing	GO:0016485	68	0.015
establishment of localization in cell	GO:0051649	402	0.015
membrane organization	GO:0061024	112	0.015	Rat
positive regulation of molecular function	GO:0044093	136	0.014
post embryonic appendage morphogenesis	GO:0035120	385	0.014
organonitrogen compound biosynthetic process	GO:1901566	117	0.014
cellular catabolic process	GO:0044248	372	0.014
ribonucleotide metabolic process	GO:0009259	145	0.014
cellular response to organic substance	GO:0071310	132	0.014
positive regulation of cellular catabolic process	GO:0031331	95	0.014
negative regulation of signaling	GO:0023057	219	0.014
positive regulation of gene expression	GO:0010628	290	0.013
regulation of localization	GO:0032879	275	0.013
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.013
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.013
positive regulation of signaling	GO:0023056	243	0.013
forebrain development	GO:0030900	2	0.013
carboxylic acid metabolic process	GO:0019752	92	0.013
organic acid metabolic process	GO:0006082	103	0.013
renal system development	GO:0072001	72	0.013
regulation of cellular component size	GO:0032535	98	0.013
morphogenesis of an epithelium	GO:0002009	276	0.013
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.013
nucleotide metabolic process	GO:0009117	161	0.013
establishment of protein localization	GO:0045184	163	0.013
positive regulation of cell death	GO:0010942	69	0.013
cell cycle arrest	GO:0007050	4	0.013
purine nucleoside metabolic process	GO:0042278	127	0.013
regulation of neurogenesis	GO:0050767	158	0.012
respiratory system development	GO:0060541	213	0.012
integrin mediated signaling pathway	GO:0007229	3	0.012
defense response	GO:0006952	300	0.012
connective tissue development	GO:0061448	3	0.012
positive regulation of phosphorus metabolic process	GO:0010562	139	0.012
regulation of proteolysis	GO:0030162	87	0.012
negative regulation of protein metabolic process	GO:0051248	85	0.012
negative regulation of cell proliferation	GO:0008285	69	0.012
regulation of organelle organization	GO:0033043	196	0.012
intracellular transport	GO:0046907	228	0.012
chemotaxis	GO:0006935	249	0.012
cellular response to chemical stimulus	GO:0070887	199	0.012
apoptotic process	GO:0006915	159	0.011
positive regulation of signal transduction	GO:0009967	223	0.011
response to ethanol	GO:0045471	59	0.011
positive regulation of wnt signaling pathway	GO:0030177	25	0.011
protein phosphorylation	GO:0006468	169	0.011
positive regulation of canonical wnt signaling pathway	GO:0090263	7	0.011
posttranscriptional regulation of gene expression	GO:0010608	145	0.011
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.011
small molecule metabolic process	GO:0044281	305	0.011
cell death	GO:0008219	279	0.011
positive regulation of cell migration	GO:0030335	2	0.011
regulation of catalytic activity	GO:0050790	185	0.011
urogenital system development	GO:0001655	72	0.011
positive regulation of cell projection organization	GO:0031346	29	0.011
organic substance catabolic process	GO:1901575	308	0.011
regulation of hydrolase activity	GO:0051336	97	0.011
substrate adhesion dependent cell spreading	GO:0034446	2	0.010
neural precursor cell proliferation	GO:0061351	75	0.010
regulation of toll signaling pathway	GO:0008592	17	0.010

AnnIX disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.019
disease of cellular proliferation	DOID:14566	0.013
musculoskeletal system disease	DOID:17	0.012

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