Drosophila melanogaster

109 known processes

tio (Dmel_CG12630)

tiptop

(Aliases: Tio,Dmel\CG12630,CG12630)

tio biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
compound eye developmentGO:00487493070.345
body morphogenesisGO:001017120.306
imaginal disc derived appendage developmentGO:00487373990.305
Fly
regionalizationGO:00030024160.263
growthGO:00400073590.260
transcription from rna polymerase ii promoterGO:00063663680.246
glial cell migrationGO:0008347310.211
epithelial cell differentiationGO:00308553220.202
axis specificationGO:00097981670.200
tissue morphogenesisGO:00487292970.191
vesicle mediated transportGO:00161923810.185
epithelial cell developmentGO:00020642740.181
neurological system processGO:00508773580.176
Mouse
negative regulation of rna metabolic processGO:00512532510.171
positive regulation of cellular biosynthetic processGO:00313283160.171
developmental inductionGO:003112830.161
positive regulation of rna metabolic processGO:00512542710.159
appendage morphogenesisGO:00351073970.156
Fly
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.151
morphogenesis of an epitheliumGO:00020092760.149
eye developmentGO:00016543230.143
positive regulation of biosynthetic processGO:00098913160.140
regulation of cell developmentGO:00602842150.139
sensory organ morphogenesisGO:00905962600.137
Mouse
photoreceptor cell differentiationGO:00465301700.132
male gamete generationGO:00482322010.130
negative regulation of cellular biosynthetic processGO:00313272770.130
establishment of localization in cellGO:00516494020.127
positive regulation of nucleobase containing compound metabolic processGO:00459353320.125
regulation of transcription from rna polymerase ii promoterGO:00063573780.125
post embryonic appendage morphogenesisGO:00351203850.124
Fly
eye morphogenesisGO:00485922600.124
positive regulation of gene expressionGO:00106282900.122
negative regulation of transcription dna templatedGO:00458922370.122
positive regulation of nitrogen compound metabolic processGO:00511733540.121
compound eye morphogenesisGO:00017452490.120
negative regulation of gene expressionGO:00106293870.120
negative regulation of nitrogen compound metabolic processGO:00511722650.115
positive regulation of macromolecule biosynthetic processGO:00105572830.115
head developmentGO:00603221350.111
regulation of multicellular organismal developmentGO:20000264140.111
developmental growthGO:00485892800.107
negative regulation of nucleobase containing compound metabolic processGO:00459342610.106
camera type eye developmentGO:004301040.104
positive regulation of transcription dna templatedGO:00458932660.103
establishment or maintenance of cell polarityGO:00071631670.103
camera type eye morphogenesisGO:004859320.103
cellular macromolecule localizationGO:00707272200.099
positive regulation of macromolecule metabolic processGO:00106044050.097
positive regulation of rna biosynthetic processGO:19026802660.097
gland developmentGO:00487321910.095
negative regulation of cell differentiationGO:00455961430.094
forebrain developmentGO:003090020.093
intracellular transportGO:00469072280.092
single organism intracellular transportGO:19025822070.092
cytoplasmic transportGO:00164821300.091
retina development in camera type eyeGO:006004140.091
protein localizationGO:00081042840.091
muscle cell differentiationGO:00426921030.089
Mouse
appendage developmentGO:00487364010.089
Fly
eye antennal disc developmentGO:0035214600.089
Fly
columnar cuboidal epithelial cell developmentGO:00020662490.089
anterior posterior pattern specificationGO:00099521360.085
Mouse
positive regulation of nucleic acid templated transcriptionGO:19035082660.083
negative regulation of cellular metabolic processGO:00313243820.082
neural retina developmentGO:000340740.077
regulation of cell differentiationGO:00455953020.077
Mouse
synaptic transmissionGO:00072682880.077
syncytium formationGO:0006949430.076
stem cell proliferationGO:0072089880.075
single organism behaviorGO:00447083910.073
myoblast fusionGO:0007520430.071
gliogenesisGO:0042063800.070
chorion containing eggshell formationGO:00073041050.068
negative regulation of developmental processGO:00510932010.068
negative regulation of nucleic acid templated transcriptionGO:19035072400.068
cell motilityGO:00488702510.065
regulation of anatomical structure morphogenesisGO:00226032420.064
neural precursor cell proliferationGO:0061351750.063
wnt signaling pathwayGO:0016055980.063
Fly
dorsal appendage formationGO:0046843470.062
brain developmentGO:00074201200.062
cellular component assembly involved in morphogenesisGO:00109271510.061
proteolysisGO:00065081920.061
cell cycle phase transitionGO:00447701400.060
endocytosisGO:00068973100.059
phagocytosisGO:00069092150.058
cell migrationGO:00164772380.058
embryo development ending in birth or egg hatchingGO:00097921520.058
Mouse Fly
dendrite morphogenesisGO:00488131990.057
negative regulation of rna biosynthetic processGO:19026792400.057
segmentationGO:00352822070.057
eye photoreceptor cell differentiationGO:00017541450.056
cell proliferationGO:00082832990.056
eggshell chorion assemblyGO:0007306660.055
telencephalon developmentGO:002153720.054
smoothened signaling pathwayGO:0007224490.053
circadian behaviorGO:0048512760.052
cell type specific apoptotic processGO:0097285380.052
negative regulation of cell communicationGO:00106482230.052
taxisGO:00423303040.052
regulation of cellular component biogenesisGO:00440872010.051
cell cell signaling involved in cell fate commitmentGO:00451682100.050
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.050
negative regulation of macromolecule biosynthetic processGO:00105582700.050
neuron projection guidanceGO:00974852410.048
salivary gland developmentGO:00074311620.047
negative regulation of multicellular organismal processGO:00512411420.047
negative regulation of response to stimulusGO:00485852580.047
single organism cellular localizationGO:19025801800.046
kidney developmentGO:000182230.046
Mouse
respiratory system developmentGO:00605412130.046
Mouse
regulation of neural precursor cell proliferationGO:2000177350.045
compound eye photoreceptor cell differentiationGO:00017511400.045
organic substance transportGO:00717022570.045
intracellular protein transportGO:00068861040.044
spermatogenesisGO:00072832000.044
ectodermal placode morphogenesisGO:007169740.044
nucleobase containing small molecule metabolic processGO:00550861740.044
establishment of protein localizationGO:00451841630.043
cell maturationGO:00484691440.042
apoptotic processGO:00069151590.042
programmed cell deathGO:00125012570.041
regulation of cell proliferationGO:00421271630.040
ectodermal placode formationGO:006078840.040
dorsal ventral pattern formationGO:00099531330.040
Fly
regulation of localizationGO:00328792750.040
embryonic morphogenesisGO:00485982060.039
Mouse Fly
proximal distal pattern formationGO:0009954150.038
Fly
regulation of multi organism processGO:00439001310.038
stem cell maintenanceGO:0019827670.037
imaginal disc derived appendage morphogenesisGO:00351143950.037
Fly
localization of cellGO:00516742570.037
imaginal disc derived wing morphogenesisGO:00074763370.037
Fly
myotube differentiationGO:0014902460.037
stem cell developmentGO:0048864790.037
mushroom body developmentGO:0016319700.036
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.036
negative regulation of nervous system developmentGO:0051961920.036
axon developmentGO:00615642970.035
protein targetingGO:0006605640.035
larval developmentGO:00021641040.034
protein transportGO:00150311550.034
rhythmic processGO:00485111060.034
central nervous system developmentGO:00074172010.033
oocyte constructionGO:00073081120.033
embryonic pattern specificationGO:00098801740.033
cellular catabolic processGO:00442483720.033
negative regulation of signal transductionGO:00099682060.033
negative regulation of biosynthetic processGO:00098902770.033
ovarian follicle cell developmentGO:00307072480.033
response to alcoholGO:0097305950.033
rhythmic behaviorGO:0007622760.033
regulation of neurogenesisGO:00507671580.033
muscle structure developmentGO:00610612240.032
Mouse
organonitrogen compound metabolic processGO:19015643180.032
response to woundingGO:0009611940.032
enzyme linked receptor protein signaling pathwayGO:00071671790.032
response to lipopolysaccharideGO:003249640.031
protein targeting to nucleusGO:0044744510.031
wing disc morphogenesisGO:00074723440.031
Fly
regulation of nervous system developmentGO:00519602480.030
negative regulation of cell developmentGO:0010721620.030
peripheral nervous system developmentGO:0007422520.030
dendrite developmentGO:00163582040.030
embryonic axis specificationGO:00005781070.029
regulation of stem cell proliferationGO:0072091400.029
regulation of cell cycle processGO:00105641810.029
intracellular signal transductionGO:00355563000.029
protein importGO:0017038550.028
ectodermal placode developmentGO:007169640.028
morphogenesis of a polarized epitheliumGO:0001738930.027
wound healingGO:0042060750.027
response to organic substanceGO:00100332840.027
adult behaviorGO:00305341370.027
ocellus developmentGO:000805640.027
small molecule metabolic processGO:00442813050.027
positive regulation of signal transductionGO:00099672230.026
axonogenesisGO:00074092900.026
protein localization to organelleGO:0033365820.026
rna localizationGO:00064031150.026
stem cell differentiationGO:00488631170.026
photoreceptor cell fate commitmentGO:0046552410.025
tripartite regional subdivisionGO:00073511030.025
chemotaxisGO:00069352490.025
regulation of cell cycleGO:00517262910.025
regulation of wnt signaling pathwayGO:0030111680.025
regulation of embryonic pattern specificationGO:1902875270.024
gland morphogenesisGO:00226121450.024
carbohydrate derivative metabolic processGO:19011352170.024
regulation of neuron differentiationGO:00456641030.024
single organism nuclear importGO:1902593510.024
cellular protein localizationGO:00346131600.024
establishment of ommatidial planar polarityGO:0042067490.024
anterior posterior axis specificationGO:00099481090.024
entrainment of circadian clockGO:0009649160.024
developmental maturationGO:00217001720.024
spermatid differentiationGO:00485151140.024
regulation of developmental growthGO:00486381740.024
aromatic compound catabolic processGO:00194391660.023
ribose phosphate metabolic processGO:00196931450.023
positive regulation of cell communicationGO:00106472500.023
leg disc developmentGO:0035218920.023
Fly
chromosome organizationGO:00512763600.023
response to ethanolGO:0045471590.023
deathGO:00162652840.023
phosphorylationGO:00163102940.022
catabolic processGO:00090564090.022
ameboidal type cell migrationGO:00016671510.022
positive regulation of signalingGO:00230562430.022
organelle localizationGO:00516401480.022
circadian rhythmGO:00076231050.022
regulation of intracellular signal transductionGO:19025312360.022
response to oxygen containing compoundGO:19017002000.022
lateral inhibitionGO:00463312060.022
sensory perception of mechanical stimulusGO:0050954720.022
Mouse
nuclear importGO:0051170510.022
negative regulation of signalingGO:00230572190.022
cellular response to chemical stimulusGO:00708871990.021
connective tissue developmentGO:006144830.021
nuclear transportGO:0051169720.021
nephron tubule developmentGO:007208030.021
establishment of planar polarityGO:0001736870.021
negative regulation of wnt signaling pathwayGO:0030178280.021
memoryGO:0007613940.021
sperm individualizationGO:0007291480.021
pigmentationGO:0043473750.020
positive regulation of response to stimulusGO:00485843230.020
regulation of catabolic processGO:00098941700.020
establishment of tissue polarityGO:0007164870.020
apoptotic process involved in developmentGO:1902742200.020
regulation of organelle organizationGO:00330431960.020
cell deathGO:00082192790.020
imaginal disc derived wing vein specificationGO:0007474480.020
response to organophosphorusGO:004668320.019
establishment of protein localization to organelleGO:0072594620.019
syncytium formation by plasma membrane fusionGO:0000768430.019
regulation of phosphate metabolic processGO:00192202100.019
nucleoside phosphate metabolic processGO:00067531620.019
organophosphate metabolic processGO:00196371950.019
exocrine system developmentGO:00352721620.019
regulation of molecular functionGO:00650092170.019
peptide metabolic processGO:0006518800.019
embryonic organ developmentGO:0048568500.019
Mouse
response to other organismGO:00517072930.019
developmental programmed cell deathGO:00106231380.018
optic placode formationGO:000174340.018
regulation of protein metabolic processGO:00512462560.018
limb developmentGO:006017310.018
ribonucleoside triphosphate metabolic processGO:00091991190.018
ras protein signal transductionGO:0007265880.018
cellular protein modification processGO:00064644380.018
ribonucleoside metabolic processGO:00091191270.018
positive regulation of developmental processGO:00510941430.018
Mouse
response to biotic stimulusGO:00096072940.018
regulation of growthGO:00400082330.018
organic substance catabolic processGO:19015753080.018
protein modification processGO:00362114380.017
oocyte developmentGO:00485991240.017
oocyte axis specificationGO:00073091080.017
regulation of epithelial cell differentiationGO:003085640.017
regulation of transportGO:00510491810.017
single organism catabolic processGO:00447122280.017
macromolecule catabolic processGO:00090571610.017
organic cyclic compound catabolic processGO:19013611680.017
axon guidanceGO:00074112330.016
neuron fate commitmentGO:0048663500.016
nucleotide metabolic processGO:00091171610.016
neuroblast differentiationGO:0014016290.016
organelle assemblyGO:00709251980.016
nucleoside triphosphate metabolic processGO:00091411200.016
cell fate specification involved in pattern specificationGO:006057380.016
nucleoside metabolic processGO:00091161270.016
eggshell formationGO:00307031050.016
retina morphogenesis in camera type eyeGO:006004220.016
purine ribonucleotide metabolic processGO:00091501450.016
cellular amine metabolic processGO:0044106120.015
optic lobe placode formationGO:000174440.015
regulation of embryonic developmentGO:0045995680.015
defense response to other organismGO:00985422250.015
posttranscriptional regulation of gene expressionGO:00106081450.015
carbohydrate derivative catabolic processGO:19011361180.015
negative regulation of transcription from rna polymerase ii promoterGO:00001221190.015
nucleocytoplasmic transportGO:0006913720.015
spermatid developmentGO:0007286980.015
regulation of reproductive processGO:2000241540.015
mesoderm developmentGO:0007498780.015
organonitrogen compound catabolic processGO:19015651280.015
regulation of cellular protein metabolic processGO:00322682430.015
oocyte differentiationGO:00099941450.015
adult locomotory behaviorGO:0008344760.015
oocyte anterior posterior axis specificationGO:0007314720.015
imaginal disc derived wing margin morphogenesisGO:0008587410.015
extrinsic apoptotic signaling pathwayGO:009719110.015
maternal determination of anterior posterior axis embryoGO:0008358740.015
bolwig s organ developmentGO:005503480.014
blood circulationGO:0008015260.014
response to bacteriumGO:00096171980.014
homeostatic processGO:00425921990.014
salivary gland histolysisGO:0035070880.014
purine ribonucleoside catabolic processGO:00461301120.014
purine nucleotide catabolic processGO:00061951090.014
histolysisGO:00075591020.014
regulation of proteolysisGO:0030162870.014
covalent chromatin modificationGO:00165691060.014
antennal developmentGO:0007469250.014
response to hexoseGO:000974630.014
hematopoietic progenitor cell differentiationGO:000224410.014
ribonucleotide catabolic processGO:00092611090.014
regulation of phosphorus metabolic processGO:00511742100.014
anterior posterior axis specification embryoGO:00085951030.014
ribonucleoside catabolic processGO:00424541120.014
regulation of cell morphogenesisGO:00226041630.014
establishment of organelle localizationGO:00516561220.014
response to endogenous stimulusGO:00097191190.013
columnar cuboidal epithelial cell differentiationGO:00020652560.013
kidney morphogenesisGO:006099330.013
Mouse
tissue deathGO:00162711020.013
nucleoside catabolic processGO:00091641120.013
positive regulation of cellular catabolic processGO:0031331950.013
regulation of insulin like growth factor receptor signaling pathwayGO:004356730.013
locomotory behaviorGO:00076261760.013
purine nucleoside metabolic processGO:00422781270.013
intracellular mrna localization involved in pattern specification processGO:0060810560.013
negative regulation of developmental growthGO:0048640640.013
purine nucleoside catabolic processGO:00061521120.013
positive regulation of phosphorus metabolic processGO:00105621390.013
nephron developmentGO:007200630.013
regulation of cell morphogenesis involved in differentiationGO:0010769610.013
cellular nitrogen compound catabolic processGO:00442701650.013
multicellular organismal reproductive behaviorGO:00330571100.013
antimicrobial humoral responseGO:0019730990.013
response to external biotic stimulusGO:00432072930.013
learning or memoryGO:00076111410.013
regulation of cellular ketone metabolic processGO:001056530.013
cell fate specificationGO:0001708710.013
defense response to bacteriumGO:00427421780.013
purine nucleotide metabolic processGO:00061631460.013
reproductive system developmentGO:0061458740.013
organelle fissionGO:00482853400.013
nucleobase containing compound catabolic processGO:00346551650.012
autophagic cell deathGO:0048102830.012
cellular macromolecule catabolic processGO:00442651360.012
equator specificationGO:004531740.012
nephron epithelium developmentGO:007200930.012
gonad developmentGO:0008406500.012
nephron morphogenesisGO:007202830.012
cell adhesionGO:00071551360.012
positive regulation of hydrolase activityGO:0051345780.012
blastoderm segmentationGO:00073501590.012
macromolecular complex assemblyGO:00650032560.012
single organism biosynthetic processGO:00447112060.012
regenerationGO:0031099160.012
chromatin modificationGO:00165681470.012
ribonucleotide metabolic processGO:00092591450.012
purine containing compound catabolic processGO:00725231120.012
cellular response to organic substanceGO:00713101320.012
cellularizationGO:0007349900.012
ribonucleoside triphosphate catabolic processGO:00092031080.012
heterocycle catabolic processGO:00467001660.012
leg disc morphogenesisGO:0007478800.012
endodermal cell differentiationGO:003598730.012
protein dna complex assemblyGO:0065004630.012
cellular amino acid metabolic processGO:0006520610.012
oxoacid metabolic processGO:00434361030.012
positive regulation of molecular functionGO:00440931360.012
positive regulation of cell migrationGO:003033520.012
cellular protein catabolic processGO:0044257830.012
nephron tubule morphogenesisGO:007207830.012
negative regulation of cellular protein metabolic processGO:0032269850.011
negative regulation of epithelial cell proliferationGO:005068040.011
response to nutrient levelsGO:00316671140.011
multi organism reproductive behaviorGO:00447051210.011
hindbrain developmentGO:003090220.011
cytoplasm organizationGO:0007028640.011
carboxylic acid metabolic processGO:0019752920.011
cardiovascular system developmentGO:0072358820.011
notch signaling pathwayGO:00072191200.011
optic lobe placode developmentGO:0001748100.011
proteasomal protein catabolic processGO:0010498590.011
outflow tract morphogenesisGO:000315140.011
sensory neuron axon guidanceGO:009737420.011
positive regulation of cell motilityGO:200014730.011
spinal cord developmentGO:002151010.011
salivary gland cell autophagic cell deathGO:0035071830.011
multi organism behaviorGO:00517051750.011
establishment or maintenance of microtubule cytoskeleton polarityGO:0030951410.011
regulation of hydrolase activityGO:0051336970.011
regulation of pole plasm oskar mrna localizationGO:0007317270.011
purine ribonucleoside metabolic processGO:00461281270.011
purine ribonucleoside triphosphate metabolic processGO:00092051190.011
multicellular organism growthGO:0035264460.011
protein phosphorylationGO:00064681690.011
response to gravityGO:0009629260.011
dorsal ventral axis specificationGO:0009950660.011
purine ribonucleotide catabolic processGO:00091541090.011
limb morphogenesisGO:003510810.011
adult walking behaviorGO:000762890.011
r7 cell differentiationGO:0045466430.011
regulation of cellular amine metabolic processGO:003323830.011
purine ribonucleoside triphosphate catabolic processGO:00092071080.011
positive regulation of catabolic processGO:00098961050.011
tube developmentGO:00352952440.011
actin cytoskeleton organizationGO:00300362060.010
synaptic transmission gabaergicGO:005193210.010
protein import into nucleus translocationGO:000006060.010
male meiosisGO:0007140520.010
regulation of oocyte developmentGO:0060281270.010
regulation of immune system processGO:00026821760.010
mitotic spindle organizationGO:00070522200.010
multi multicellular organism processGO:00447061230.010
regulation of cellular catabolic processGO:00313291570.010
regulation of cellular component sizeGO:0032535980.010
photoreceptor cell developmentGO:0042461960.010
response to abiotic stimulusGO:00096283410.010
developmental pigmentationGO:0048066680.010
carbohydrate metabolic processGO:0005975820.010
regulation of epithelial cell proliferationGO:005067840.010
circulatory system developmentGO:0072359820.010
pyridine nucleotide metabolic processGO:001936220.010
neuron neuron synaptic transmissionGO:0007270140.010
amine metabolic processGO:0009308120.010
cranial nerve developmentGO:002154510.010

tio disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.025
disease of anatomical entityDOID:700.025
physical disorderDOID:008001500.021
congenital nervous system abnormalityDOID:249000.021
sensory system diseaseDOID:005015500.015
eye diseaseDOID:561400.014
eye and adnexa diseaseDOID:149200.014