IMP: Integrative Multi-species Prediction

Drosophila melanogaster

219 known processes

Abl (Dmel_CG4032)

Abl tyrosine kinase

(Aliases: dAbl,DROTKABL3,Abl1,CG4032,Dsrc7,AblK,Ableson,cAbl,DAbl,4674,abl,l(3)73Ba,D-abl,c-abl,Dabl,l(3)04674,ABL,l(3)c-abl,Ddash/abl,Dmel\CG4032,C-abl,Dash,D-ash,Am ABL,abl1)

Entrez: 45821
FLYBASE: FBgn0000017
UniProtKB: M9PFI5
UniProtKB: M9PFI8
UniProtKB: M9PI83
UniProtKB: M9PCT8
UniProtKB: P00522
UniProtKB: M9PFS1
UniProtKB: M9PCU1
UniProtKB: M9PFX0
UniProtKB: A8JNU2
UniProtKB: X2JGR4

Process Predictions
Disease Predictions

Abl biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
axon development	GO:0061564	297	0.999
axonogenesis	GO:0007409	290	0.999
neuron projection guidance	GO:0097485	241	0.998
taxis	GO:0042330	304	0.993
axon guidance	GO:0007411	233	0.989
motor neuron axon guidance	GO:0008045	58	0.979
regulation of nervous system development	GO:0051960	248	0.956
regulation of dendrite morphogenesis	GO:0048814	28	0.951
developmental growth	GO:0048589	280	0.913
regulation of cell development	GO:0060284	215	0.878	Human Mouse Rat
regulation of cell projection organization	GO:0031344	92	0.856	Human Mouse Rat
negative regulation of gene expression	GO:0010629	387	0.854
regulation of cell differentiation	GO:0045595	302	0.853	Human Mouse Rat
regulation of localization	GO:0032879	275	0.825
neuromuscular junction development	GO:0007528	149	0.816
positive regulation of cell migration	GO:0030335	2	0.811
cell migration	GO:0016477	238	0.798
dorsal ventral axon guidance	GO:0033563	2	0.793
growth	GO:0040007	359	0.787
regulation of multicellular organismal development	GO:2000026	414	0.783
regulation of neuron differentiation	GO:0045664	103	0.780	Human Mouse Rat
synaptic transmission	GO:0007268	288	0.766
synapse assembly	GO:0007416	143	0.761
regulation of cell morphogenesis	GO:0022604	163	0.731
negative regulation of cell communication	GO:0010648	223	0.730	Mouse Worm
regulation of axon extension involved in axon guidance	GO:0048841	4	0.725
membrane organization	GO:0061024	112	0.723	Worm
chemotaxis	GO:0006935	249	0.719
positive regulation of cell motility	GO:2000147	3	0.698
eye development	GO:0001654	323	0.682
regulation of dendrite development	GO:0050773	37	0.668	Rat
positive regulation of macromolecule metabolic process	GO:0010604	405	0.647	Human
regulation of protein metabolic process	GO:0051246	256	0.618	Human
regulation of cellular protein metabolic process	GO:0032268	243	0.612	Human
dendrite morphogenesis	GO:0048813	199	0.607	Mouse
sensory organ morphogenesis	GO:0090596	260	0.594
regulation of cell proliferation	GO:0042127	163	0.584	Mouse Rat
regulation of cell adhesion	GO:0030155	27	0.580	Mouse
actomyosin structure organization	GO:0031032	56	0.572
substrate dependent cell migration	GO:0006929	3	0.566	Mouse
cell recognition	GO:0008037	102	0.550
negative regulation of cellular metabolic process	GO:0031324	382	0.545	Human Mouse
compound eye morphogenesis	GO:0001745	249	0.540
actin filament based process	GO:0030029	220	0.534	Mouse Rat
regulation of synapse assembly	GO:0051963	94	0.523
morphogenesis of embryonic epithelium	GO:0016331	94	0.512
regulation of cellular component biogenesis	GO:0044087	201	0.507
regulation of molecular function	GO:0065009	217	0.503	Human Mouse
macromolecular complex assembly	GO:0065003	256	0.503	Rat
cellular protein modification process	GO:0006464	438	0.502
dorsal closure	GO:0007391	79	0.488
negative regulation of response to stimulus	GO:0048585	258	0.474	Mouse Worm
endocytosis	GO:0006897	310	0.463	Mouse Worm
multi organism reproductive behavior	GO:0044705	121	0.454
positive regulation of signaling	GO:0023056	243	0.451	Mouse
ovarian follicle cell development	GO:0030707	248	0.450
axon extension involved in axon guidance	GO:0048846	10	0.446
regulation of axonogenesis	GO:0050770	32	0.444
regulation of cell migration	GO:0030334	22	0.443	Worm
axon extension	GO:0048675	32	0.440
positive regulation of cellular component organization	GO:0051130	156	0.424	Human Mouse Rat
positive regulation of nervous system development	GO:0051962	69	0.416	Human Mouse Rat
dendrite development	GO:0016358	204	0.411	Mouse Rat
positive regulation of cell adhesion	GO:0045785	10	0.410
negative regulation of growth	GO:0045926	84	0.404
cortical actin cytoskeleton organization	GO:0030866	24	0.403
regulation of growth	GO:0040008	233	0.403
synapse organization	GO:0050808	196	0.400
embryo development ending in birth or egg hatching	GO:0009792	152	0.399
cell adhesion	GO:0007155	136	0.399	Mouse
locomotory behavior	GO:0007626	176	0.392
protein localization	GO:0008104	284	0.388
regulation of cell death	GO:0010941	173	0.387	Human Mouse Rat Worm
vesicle mediated transport	GO:0016192	381	0.386	Mouse Worm
regulation of cell shape	GO:0008360	113	0.383
axon choice point recognition	GO:0016198	26	0.381
regulation of catalytic activity	GO:0050790	185	0.372	Human
regulation of developmental growth	GO:0048638	174	0.372
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.363
cytokinesis	GO:0000910	90	0.354
regulation of protein modification process	GO:0031399	112	0.353	Human
regulation of phosphorus metabolic process	GO:0051174	210	0.351	Human Mouse
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.349
cortical cytoskeleton organization	GO:0030865	29	0.345
cell division	GO:0051301	248	0.345
positive regulation of cell projection organization	GO:0031346	29	0.344	Human Mouse Rat
cell proliferation	GO:0008283	299	0.333	Mouse Rat
regulation of protein polymerization	GO:0032271	28	0.331
regulation of response to stress	GO:0080134	200	0.330	Human Mouse Rat Worm
maintenance of protein location in cell	GO:0032507	26	0.329
cell growth	GO:0016049	108	0.328	Mouse
positive regulation of cellular component biogenesis	GO:0044089	80	0.328
developmental maturation	GO:0021700	172	0.318	Mouse
regulation of neuron projection development	GO:0010975	69	0.310	Human Mouse Rat
cytoskeleton dependent cytokinesis	GO:0061640	81	0.305
regulation of cellular component movement	GO:0051270	42	0.303	Worm
regulation of phosphorylation	GO:0042325	147	0.287	Human Mouse
renal filtration	GO:0097205	7	0.283
germarium derived egg chamber formation	GO:0007293	101	0.277
positive regulation of response to stimulus	GO:0048584	323	0.275	Mouse Rat
immune system process	GO:0002376	347	0.273	Mouse
protein modification process	GO:0036211	438	0.272
negative regulation of cellular component organization	GO:0051129	108	0.270
regulation of cell motility	GO:2000145	23	0.269	Worm
cell projection assembly	GO:0030031	94	0.265	Mouse
regulation of intracellular signal transduction	GO:1902531	236	0.262	Mouse Worm
chorion containing eggshell formation	GO:0007304	105	0.260
single organism cellular localization	GO:1902580	180	0.260
regulation of cytoskeleton organization	GO:0051493	89	0.258	Mouse
negative regulation of catalytic activity	GO:0043086	42	0.257	Human
axon midline choice point recognition	GO:0016199	26	0.253
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.252	Mouse
eye morphogenesis	GO:0048592	260	0.252
neuron recognition	GO:0008038	101	0.251
positive regulation of signal transduction	GO:0009967	223	0.248	Mouse
intracellular signal transduction	GO:0035556	300	0.247	Human Mouse Worm
nucleus localization	GO:0051647	34	0.243
positive regulation of neurogenesis	GO:0050769	41	0.238	Human Mouse Rat
negative regulation of signaling	GO:0023057	219	0.238	Mouse Worm
regulation of axon guidance	GO:1902667	10	0.238
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.234
negative regulation of cell cycle	GO:0045786	116	0.232	Mouse
mitotic cytokinesis	GO:0000281	50	0.227
localization of cell	GO:0051674	257	0.226
cellular macromolecule localization	GO:0070727	220	0.226
negative regulation of cellular protein metabolic process	GO:0032269	85	0.226	Human
positive regulation of cytoskeleton organization	GO:0051495	21	0.224
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	12	0.222
actin cytoskeleton organization	GO:0030036	206	0.217	Mouse Rat
actin filament bundle organization	GO:0061572	28	0.216	Mouse
oocyte development	GO:0048599	124	0.215
morphogenesis of an epithelium	GO:0002009	276	0.214
establishment or maintenance of cytoskeleton polarity	GO:0030952	44	0.214
response to endogenous stimulus	GO:0009719	119	0.212	Rat
neuron projection extension	GO:1990138	32	0.208
oocyte differentiation	GO:0009994	145	0.208
oocyte microtubule cytoskeleton organization	GO:0016325	35	0.203
lamellipodium organization	GO:0097581	21	0.203
establishment of localization in cell	GO:0051649	402	0.198
positive regulation of cell communication	GO:0010647	250	0.198	Mouse
kidney development	GO:0001822	3	0.195
maintenance of location	GO:0051235	73	0.192
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.192
positive regulation of axonogenesis	GO:0050772	2	0.192
purine ribonucleotide catabolic process	GO:0009154	109	0.190
regulation of synaptic transmission	GO:0050804	69	0.190
protein phosphorylation	GO:0006468	169	0.187
neuroblast differentiation	GO:0014016	29	0.183
initiation of dorsal closure	GO:0007392	12	0.183
negative regulation of cellular biosynthetic process	GO:0031327	277	0.180
regulation of epithelial cell migration open tracheal system	GO:2000274	11	0.179
cell death	GO:0008219	279	0.179	Human Mouse Rat Worm
programmed cell death	GO:0012501	257	0.178	Human Mouse Rat Worm
positive regulation of cell development	GO:0010720	61	0.176	Human Mouse Rat
cellular response to chemical stimulus	GO:0070887	199	0.176	Human Mouse Rat
small molecule metabolic process	GO:0044281	305	0.172
regulation of actin filament based process	GO:0032970	42	0.169	Mouse
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.169
regulation of anatomical structure morphogenesis	GO:0022603	242	0.168
embryonic development via the syncytial blastoderm	GO:0001700	148	0.168
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.168
positive regulation of axon extension	GO:0045773	2	0.166
single organism membrane organization	GO:0044802	93	0.165
regulation of cellular ketone metabolic process	GO:0010565	3	0.164
endodermal cell differentiation	GO:0035987	3	0.163
developmental growth involved in morphogenesis	GO:0060560	65	0.163
regulation of cellular localization	GO:0060341	136	0.162
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.161
central nervous system development	GO:0007417	201	0.159
purine containing compound metabolic process	GO:0072521	155	0.157
spindle organization	GO:0007051	253	0.156
positive regulation of programmed cell death	GO:0043068	62	0.154	Human Mouse Rat
protein acetylation	GO:0006473	39	0.152
morphogenesis of a branching epithelium	GO:0061138	45	0.151
regulation of synapse structure and activity	GO:0050803	128	0.151
appendage development	GO:0048736	401	0.149
regulation of cell substrate adhesion	GO:0010810	2	0.149
regulation of organelle organization	GO:0033043	196	0.148	Mouse
developmental cell growth	GO:0048588	52	0.145	Mouse
spermatogenesis	GO:0007283	200	0.143	Worm
epidermis development	GO:0008544	65	0.143
peptidyl amino acid modification	GO:0018193	105	0.142
larval development	GO:0002164	104	0.141
response to organic substance	GO:0010033	284	0.140	Human Mouse Rat
regulation of lamellipodium organization	GO:1902743	15	0.137
mitotic nuclear division	GO:0007067	213	0.136
endodermal cell fate commitment	GO:0001711	3	0.135
gonad morphogenesis	GO:0035262	7	0.135
skin development	GO:0043588	65	0.134
actin filament organization	GO:0007015	126	0.134	Mouse Rat
negative regulation of biosynthetic process	GO:0009890	277	0.134
regulation of neurogenesis	GO:0050767	158	0.134	Human Mouse Rat
kidney epithelium development	GO:0072073	3	0.132
sensory perception	GO:0007600	196	0.132
neuroblast fate commitment	GO:0014017	19	0.131
compound eye development	GO:0048749	307	0.129
regulation of cell cycle	GO:0051726	291	0.129	Mouse
regulation of response to external stimulus	GO:0032101	115	0.129
hair cell differentiation	GO:0035315	47	0.128
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.127
positive regulation of cellular biosynthetic process	GO:0031328	316	0.127
imaginal disc derived appendage development	GO:0048737	399	0.126
establishment or maintenance of cell polarity	GO:0007163	167	0.126
maintenance of location in cell	GO:0051651	28	0.126
single organism behavior	GO:0044708	391	0.125	Mouse Rat
regulation of cellular amine metabolic process	GO:0033238	3	0.124
regulation of cellular response to stress	GO:0080135	89	0.122	Human Mouse Rat Worm
positive regulation of cell differentiation	GO:0045597	64	0.122	Human Mouse Rat
hemocyte migration	GO:0035099	19	0.121
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.121
body morphogenesis	GO:0010171	2	0.120
death	GO:0016265	284	0.119	Human Mouse Rat Worm
cellular protein localization	GO:0034613	160	0.118
regulation of lamellipodium assembly	GO:0010591	15	0.118
oocyte axis specification	GO:0007309	108	0.118
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.118	Mouse
small gtpase mediated signal transduction	GO:0007264	88	0.116	Mouse
secretion by cell	GO:0032940	101	0.115	Mouse
regulation of cellular amino acid metabolic process	GO:0006521	0	0.115
filopodium assembly	GO:0046847	33	0.114
positive regulation of axon guidance	GO:1902669	1	0.114
regulation of synapse organization	GO:0050807	110	0.113
compound eye retinal cell programmed cell death	GO:0046667	23	0.113
positive regulation of developmental process	GO:0051094	143	0.113	Human Mouse Rat
positive regulation of protein metabolic process	GO:0051247	128	0.112	Human
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.111
positive regulation of transcription dna templated	GO:0045893	266	0.110
glial cell migration	GO:0008347	31	0.110
axis specification	GO:0009798	167	0.109
jnk cascade	GO:0007254	50	0.109
nucleobase containing small molecule metabolic process	GO:0055086	174	0.108
regulation of protein transport	GO:0051223	57	0.108
mapk cascade	GO:0000165	107	0.108	Mouse
regulation of transferase activity	GO:0051338	58	0.108	Human
regulation of mapk cascade	GO:0043408	92	0.108	Mouse
negative regulation of developmental process	GO:0051093	201	0.107
protein complex assembly	GO:0006461	200	0.107	Rat
regulation of apoptotic process	GO:0042981	130	0.107	Human Mouse Rat Worm
blastoderm segmentation	GO:0007350	159	0.107
embryonic organ development	GO:0048568	50	0.106
purine nucleotide metabolic process	GO:0006163	146	0.105
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.104
gonad development	GO:0008406	50	0.104
reproductive system development	GO:0061458	74	0.104
male gamete generation	GO:0048232	201	0.103	Worm
maintenance of protein location	GO:0045185	28	0.101
forebrain development	GO:0030900	2	0.101
positive regulation of rna metabolic process	GO:0051254	271	0.101
negative regulation of rna biosynthetic process	GO:1902679	240	0.100
synaptic growth at neuromuscular junction	GO:0051124	119	0.099
establishment of nucleus localization	GO:0040023	26	0.099
positive regulation of filopodium assembly	GO:0051491	15	0.099
stress activated protein kinase signaling cascade	GO:0031098	55	0.098
neurotransmitter secretion	GO:0007269	35	0.098
regulation of cell cycle process	GO:0010564	181	0.097
embryonic morphogenesis	GO:0048598	206	0.096
regulation of notch signaling pathway	GO:0008593	100	0.096
rhythmic process	GO:0048511	106	0.095
cellular response to endogenous stimulus	GO:0071495	80	0.095	Rat
oocyte construction	GO:0007308	112	0.094
positive regulation of gene expression	GO:0010628	290	0.093
gastrulation	GO:0007369	70	0.093
protein catabolic process	GO:0030163	101	0.093
biological adhesion	GO:0022610	138	0.093	Mouse
cuticle development	GO:0042335	86	0.092
microtubule anchoring	GO:0034453	11	0.092
regulation of protein serine threonine kinase activity	GO:0071900	25	0.092	Human
retinal ganglion cell axon guidance	GO:0031290	12	0.092
epithelial cell differentiation	GO:0030855	322	0.091
regulation of cell cell adhesion	GO:0022407	21	0.091	Mouse
axonal defasciculation	GO:0007414	12	0.091
negative regulation of phosphorylation	GO:0042326	35	0.091	Human Mouse
phagocytosis	GO:0006909	215	0.091	Mouse Worm
intracellular transport	GO:0046907	228	0.091
peptidyl lysine acetylation	GO:0018394	39	0.091
positive regulation of catalytic activity	GO:0043085	118	0.088	Human
nuclear division	GO:0000280	332	0.087
phenol containing compound metabolic process	GO:0018958	57	0.086
g protein coupled receptor signaling pathway	GO:0007186	136	0.086
intracellular protein transport	GO:0006886	104	0.085
gliogenesis	GO:0042063	80	0.085	Mouse
regulation of epithelial cell migration	GO:0010632	12	0.085
organelle fission	GO:0048285	340	0.085
establishment of organelle localization	GO:0051656	122	0.085
signal release	GO:0023061	49	0.085
multi organism behavior	GO:0051705	175	0.084
negative regulation of signal transduction	GO:0009968	206	0.083	Mouse Worm
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.083
anterior posterior pattern specification	GO:0009952	136	0.082
regulation of locomotion	GO:0040012	42	0.081	Worm
digestive system development	GO:0055123	149	0.081
regulation of transport	GO:0051049	181	0.081
proteolysis	GO:0006508	192	0.080
gtp catabolic process	GO:0006184	72	0.079
regulation of protein kinase activity	GO:0045859	51	0.079	Human
lamellipodium assembly	GO:0030032	21	0.079
cellular amino acid metabolic process	GO:0006520	61	0.078
cellular response to growth factor stimulus	GO:0071363	30	0.078	Rat
organic substance transport	GO:0071702	257	0.078
dorsal appendage formation	GO:0046843	47	0.078
ribonucleotide catabolic process	GO:0009261	109	0.078
signal transduction by phosphorylation	GO:0023014	107	0.078	Mouse
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.077
cytoplasmic transport nurse cell to oocyte	GO:0007303	12	0.074
response to wounding	GO:0009611	94	0.074
ribose phosphate metabolic process	GO:0019693	145	0.073
phosphorylation	GO:0016310	294	0.073
lateral inhibition	GO:0046331	206	0.073
camera type eye development	GO:0043010	4	0.073
regulation of cell growth	GO:0001558	43	0.073
negative regulation of phosphate metabolic process	GO:0045936	45	0.073	Human Mouse
single organism cell adhesion	GO:0098602	47	0.072	Mouse
regulation of cell projection assembly	GO:0060491	30	0.072
positive regulation of protein modification process	GO:0031401	58	0.071	Human
columnar cuboidal epithelial cell development	GO:0002066	249	0.071
negative regulation of erbb signaling pathway	GO:1901185	29	0.071
brain development	GO:0007420	120	0.071	Mouse
regulation of wnt signaling pathway	GO:0030111	68	0.071	Mouse
regulation of establishment of protein localization	GO:0070201	61	0.071
tissue morphogenesis	GO:0048729	297	0.070
organophosphate metabolic process	GO:0019637	195	0.070
neurotransmitter transport	GO:0006836	37	0.070
negative regulation of developmental growth	GO:0048640	64	0.069
positive regulation of locomotion	GO:0040017	8	0.069
endoderm formation	GO:0001706	3	0.069
negative regulation of rna metabolic process	GO:0051253	251	0.069
regulation of stress activated protein kinase signaling cascade	GO:0070302	42	0.069
post embryonic appendage morphogenesis	GO:0035120	385	0.069
positive regulation of molecular function	GO:0044093	136	0.069	Human Mouse
eye photoreceptor cell development	GO:0042462	81	0.069
regulation of kinase activity	GO:0043549	53	0.068	Human
cellular homeostasis	GO:0019725	80	0.068	Human Mouse
actin filament bundle assembly	GO:0051017	26	0.068	Mouse
nucleotide metabolic process	GO:0009117	161	0.068
regulation of axon extension	GO:0030516	8	0.068
telencephalon development	GO:0021537	2	0.068
cell fate determination	GO:0001709	91	0.068
regulation of proteolysis	GO:0030162	87	0.067
regulation of compound eye retinal cell programmed cell death	GO:0046669	18	0.067
reproductive behavior	GO:0019098	122	0.067
single organismal cell cell adhesion	GO:0016337	45	0.067	Mouse
cellular ketone metabolic process	GO:0042180	24	0.067
protein transport	GO:0015031	155	0.067
organelle localization	GO:0051640	148	0.066
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.066
regulation of cellular protein catabolic process	GO:1903362	44	0.065
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	41	0.065
positive regulation of cell proliferation	GO:0008284	47	0.065	Mouse Rat
positive regulation of rna biosynthetic process	GO:1902680	266	0.065
cellular protein complex assembly	GO:0043623	71	0.065	Rat
stem cell development	GO:0048864	79	0.064
nuclear migration	GO:0007097	20	0.064
eggshell formation	GO:0030703	105	0.064
positive regulation of jun kinase activity	GO:0043507	4	0.063
macromolecule catabolic process	GO:0009057	161	0.063
positive regulation of phosphorus metabolic process	GO:0010562	139	0.063	Human Mouse
negative regulation of epithelial cell proliferation	GO:0050680	4	0.063
positive regulation of neuron differentiation	GO:0045666	26	0.062	Human Mouse Rat
positive regulation of lipid metabolic process	GO:0045834	4	0.062
negative regulation of cell cycle process	GO:0010948	109	0.062
cytoplasmic transport	GO:0016482	130	0.061
compound eye photoreceptor cell differentiation	GO:0001751	140	0.060
imaginal disc derived wing morphogenesis	GO:0007476	337	0.060
internal protein amino acid acetylation	GO:0006475	38	0.060
negative regulation of cytoskeleton organization	GO:0051494	30	0.059
transcription from rna polymerase ii promoter	GO:0006366	368	0.059
negative regulation of protein modification process	GO:0031400	29	0.059	Human
organonitrogen compound metabolic process	GO:1901564	318	0.059
hemopoiesis	GO:0030097	46	0.058	Mouse
cell motility	GO:0048870	251	0.058
head development	GO:0060322	135	0.058	Mouse
regionalization	GO:0003002	416	0.057
spinal cord development	GO:0021510	1	0.056
secretion	GO:0046903	109	0.056	Mouse
protein complex biogenesis	GO:0070271	201	0.056	Rat
regulation of microtubule based process	GO:0032886	49	0.056
positive regulation of cellular protein metabolic process	GO:0032270	118	0.056	Human
negative regulation of proteolysis	GO:0045861	31	0.055
stress activated mapk cascade	GO:0051403	52	0.055
anterior posterior axis specification	GO:0009948	109	0.055
cell cycle arrest	GO:0007050	4	0.055
peptidyl lysine modification	GO:0018205	57	0.055
axon regeneration	GO:0031103	8	0.055
mitotic cell cycle phase transition	GO:0044772	138	0.054
oocyte anterior posterior axis specification	GO:0007314	72	0.054
open tracheal system development	GO:0007424	204	0.053
cellular catabolic process	GO:0044248	372	0.052
cellular macromolecular complex assembly	GO:0034622	153	0.051	Rat
mitotic spindle organization	GO:0007052	220	0.051
positive regulation of transport	GO:0051050	92	0.051
leg disc morphogenesis	GO:0007478	80	0.051
protein polymerization	GO:0051258	42	0.051	Rat
amine metabolic process	GO:0009308	12	0.050
collateral sprouting	GO:0048668	3	0.050	Mouse
epidermal cell differentiation	GO:0009913	51	0.050
smoothened signaling pathway	GO:0007224	49	0.050
nucleoside phosphate metabolic process	GO:0006753	162	0.049
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.049
epithelial cell development	GO:0002064	274	0.049
dorsal closure elongation of leading edge cells	GO:0007394	10	0.049
purine nucleoside catabolic process	GO:0006152	112	0.048
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.048
negative regulation of phosphorus metabolic process	GO:0010563	45	0.048	Human Mouse
catabolic process	GO:0009056	409	0.048
positive regulation of phosphate metabolic process	GO:0045937	139	0.048	Human Mouse
homeostatic process	GO:0042592	199	0.048	Human Mouse
positive regulation of cell growth	GO:0030307	19	0.047
negative regulation of neurogenesis	GO:0050768	53	0.047
internal peptidyl lysine acetylation	GO:0018393	38	0.047
protein maturation	GO:0051604	71	0.047
regulation of microtubule polymerization or depolymerization	GO:0031110	27	0.047
nucleoside catabolic process	GO:0009164	112	0.046
leg disc development	GO:0035218	92	0.046
regulation of hydrolase activity	GO:0051336	97	0.046	Human
regulation of protein localization	GO:0032880	76	0.046
single organism catabolic process	GO:0044712	228	0.046
oocyte dorsal ventral axis specification	GO:0007310	34	0.046
aging	GO:0007568	143	0.046	Mouse
dorsal ventral axis specification	GO:0009950	66	0.045
oocyte localization involved in germarium derived egg chamber formation	GO:0030720	12	0.045
tube development	GO:0035295	244	0.045
ribonucleoside metabolic process	GO:0009119	127	0.045
regulation of cell size	GO:0008361	63	0.044
myoblast proliferation	GO:0051450	3	0.044
negative regulation of cell development	GO:0010721	62	0.044
regulation of jnk cascade	GO:0046328	40	0.043
regulation of embryonic development	GO:0045995	68	0.043
immune response regulating signaling pathway	GO:0002764	2	0.043	Mouse
single organism intracellular transport	GO:1902582	207	0.043
regulation of epithelial cell proliferation	GO:0050678	4	0.043
protein processing	GO:0016485	68	0.042
intracellular mrna localization involved in pattern specification process	GO:0060810	56	0.042
regulation of retinal cell programmed cell death	GO:0046668	18	0.042
regulation of chemotaxis	GO:0050920	12	0.042
wound healing	GO:0042060	75	0.042
nucleotide catabolic process	GO:0009166	109	0.042
wing disc morphogenesis	GO:0007472	344	0.041
regulation of nucleotide metabolic process	GO:0006140	62	0.041
regulation of cellular component size	GO:0032535	98	0.041
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.041
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.041
positive regulation of proteolysis	GO:0045862	52	0.040
extrinsic apoptotic signaling pathway	GO:0097191	1	0.040
response to external biotic stimulus	GO:0043207	293	0.040	Mouse Worm
nucleoside metabolic process	GO:0009116	127	0.040
mesoderm development	GO:0007498	78	0.040
regulation of response to wounding	GO:1903034	19	0.040
positive regulation of protein complex assembly	GO:0031334	22	0.040
anatomical structure homeostasis	GO:0060249	97	0.039
vesicle localization	GO:0051648	55	0.039
positive regulation of biosynthetic process	GO:0009891	316	0.039
pole plasm oskar mrna localization	GO:0045451	46	0.039
hematopoietic or lymphoid organ development	GO:0048534	57	0.039	Mouse
negative regulation of cell differentiation	GO:0045596	143	0.039
regulation of microtubule cytoskeleton organization	GO:0070507	41	0.039
determination of adult lifespan	GO:0008340	137	0.038
compound eye photoreceptor development	GO:0042051	78	0.038
positive regulation of synapse assembly	GO:0051965	29	0.038
glycosyl compound catabolic process	GO:1901658	112	0.038
circadian behavior	GO:0048512	76	0.038
regulation of filopodium assembly	GO:0051489	24	0.038
positive regulation of catabolic process	GO:0009896	105	0.037
positive regulation of cellular amine metabolic process	GO:0033240	0	0.037
neuron projection extension involved in neuron projection guidance	GO:1902284	10	0.037
cellular response to dna damage stimulus	GO:0006974	223	0.037	Human Worm
axon target recognition	GO:0007412	16	0.037
cellularization	GO:0007349	90	0.037
ras protein signal transduction	GO:0007265	88	0.037	Mouse
hindbrain development	GO:0030902	2	0.037	Mouse
regulation of behavior	GO:0050795	75	0.037
regulation of phosphatase activity	GO:0010921	3	0.037
regulation of pole plasm oskar mrna localization	GO:0007317	27	0.036
negative regulation of transcription dna templated	GO:0045892	237	0.036
organic hydroxy compound metabolic process	GO:1901615	83	0.036
purine containing compound catabolic process	GO:0072523	112	0.036
adult behavior	GO:0030534	137	0.036
negative regulation of synaptic growth at neuromuscular junction	GO:0045886	39	0.036
negative regulation of cell migration	GO:0030336	5	0.036	Worm
response to metal ion	GO:0010038	23	0.036
pole plasm mrna localization	GO:0019094	49	0.036
stem cell proliferation	GO:0072089	88	0.036
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.035
negative regulation of protein metabolic process	GO:0051248	85	0.035	Human
positive regulation of nucleotide metabolic process	GO:0045981	55	0.035
organic cyclic compound catabolic process	GO:1901361	168	0.035
spermatid differentiation	GO:0048515	114	0.035
regulation of gtp catabolic process	GO:0033124	44	0.035
nucleoside triphosphate metabolic process	GO:0009141	120	0.035
negative regulation of synapse assembly	GO:0051964	39	0.035
negative regulation of epithelial cell migration	GO:0010633	1	0.034
regulation of mitotic cell cycle	GO:0007346	190	0.034	Mouse
regulation of protein processing	GO:0070613	32	0.034

Abl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
organ system cancer	DOID:0050686	0.250
disease of cellular proliferation	DOID:14566	0.250
cancer	DOID:162	0.250
disease of anatomical entity	DOID:7	0.189

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