Drosophila melanogaster

192 known processes

lok (Dmel_CG10895)

loki

(Aliases: mnk,chk2,MNK,Dmnk-L,CHK-2,CG10895,10895,DmCHk2,CHK2,DmChk2,Dmnk-S,Dmnk,Dmchk2,Dmel\CG10895,chk,Chk2,38B.4,chk2/lok,LOKI/CHK2,Dmnk/DChk2)

lok biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular response to dna damage stimulusGO:00069742231.000
double strand break repairGO:0006302260.996
Human
recombinational repairGO:0000725130.994
double strand break repair via nonhomologous end joiningGO:000630350.994
dna duplex unwindingGO:0032508160.994
negative regulation of cell cycle phase transitionGO:19019881030.992
dna metabolic processGO:00062592270.992
reciprocal meiotic recombinationGO:0007131190.989
mitotic dna integrity checkpointGO:0044774750.988
dna repairGO:0006281540.986
non recombinational repairGO:000072670.982
cell cycle checkpointGO:0000075950.982
negative regulation of mitotic cell cycleGO:00459301090.981
mitotic dna damage checkpointGO:0044773740.975
dna damage checkpointGO:0000077780.972
negative regulation of mitotic cell cycle phase transitionGO:19019911030.972
double strand break repair via homologous recombinationGO:0000724130.970
mitotic g2 m transition checkpointGO:0044818700.966
dna integrity checkpointGO:0031570810.964
negative regulation of cell cycle processGO:00109481090.963
agingGO:00075681430.953
dna recombinationGO:0006310320.949
g2 dna damage checkpointGO:0031572690.930
regulation of mitotic cell cycleGO:00073461900.916
meiotic nuclear divisionGO:00071261510.912
Worm
dna geometric changeGO:0032392160.902
negative regulation of cell cycleGO:00457861160.886
meiotic cell cycle processGO:19030461320.879
Worm
mitotic cell cycle checkpointGO:0007093880.875
dna double strand break processingGO:000072930.860
double strand break repair via synthesis dependent strand annealingGO:004500360.858
chromatin modificationGO:00165681470.849
anatomical structure homeostasisGO:0060249970.848
meiosis iGO:0007127590.842
regulation of mitotic cell cycle phase transitionGO:19019901300.841
negative regulation of nucleobase containing compound metabolic processGO:00459342610.837
Human
mitotic g2 dna damage checkpointGO:0007095690.834
response to uvGO:0009411240.823
response to abiotic stimulusGO:00096283410.820
regulation of protein metabolic processGO:00512462560.805
regulation of cell cycle processGO:00105641810.800
regulation of cell cycle phase transitionGO:19019871300.800
nucleotide excision repairGO:000628980.788
response to ionizing radiationGO:0010212320.788
regulation of cell cycleGO:00517262910.783
cell proliferationGO:00082832990.782
determination of adult lifespanGO:00083401370.768
regulation of autophagyGO:0010506620.752
telomere organizationGO:0032200210.745
reciprocal dna recombinationGO:0035825190.739
cell divisionGO:00513012480.715
cell cycle phase transitionGO:00447701400.689
regulation of response to stressGO:00801342000.664
chromatin organizationGO:00063252070.650
negative regulation of cellular biosynthetic processGO:00313272770.577
Human
regulation of dna recombinationGO:000001840.574
chromosome organizationGO:00512763600.570
response to oxidative stressGO:0006979860.566
regulation of dna metabolic processGO:0051052340.566
response to radiationGO:00093141550.556
negative regulation of gene expressionGO:00106293870.553
multicellular organismal agingGO:00102591400.550
telomere maintenanceGO:0000723210.533
negative regulation of nitrogen compound metabolic processGO:00511722650.521
Human
response to light stimulusGO:00094161240.518
female meiotic divisionGO:0007143700.507
negative regulation of cellular metabolic processGO:00313243820.497
Human
regulation of dna repairGO:000628250.495
regulation of transcription from rna polymerase ii promoterGO:00063573780.462
dna synthesis involved in dna repairGO:000073150.447
positive regulation of rna biosynthetic processGO:19026802660.442
regulation of gene expression epigeneticGO:00400291280.439
dna conformation changeGO:00711031050.438
mitotic cell cycle phase transitionGO:00447721380.422
translesion synthesisGO:001998520.411
nuclear divisionGO:00002803320.409
Human Worm
negative regulation of biosynthetic processGO:00098902770.404
Human
embryo development ending in birth or egg hatchingGO:00097921520.395
Worm
negative regulation of developmental processGO:00510932010.391
chromatin remodelingGO:0006338720.358
positive regulation of cellular biosynthetic processGO:00313283160.348
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630110.342
positive regulation of nitrogen compound metabolic processGO:00511733540.341
transcription from rna polymerase ii promoterGO:00063663680.334
regulation of response to dna damage stimulusGO:2001020230.328
negative regulation of transcription dna templatedGO:00458922370.319
cellular response to organic substanceGO:00713101320.319
organelle fissionGO:00482853400.313
Human Worm
meiotic cell cycleGO:00513211710.313
Worm
postreplication repairGO:000630120.309
response to organic substanceGO:00100332840.297
positive regulation of macromolecule metabolic processGO:00106044050.270
homeostatic processGO:00425921990.266
negative regulation of protein metabolic processGO:0051248850.265
cellular catabolic processGO:00442483720.264
Human
regulation of multicellular organismal developmentGO:20000264140.253
positive regulation of autophagyGO:0010508210.249
positive regulation of nucleobase containing compound metabolic processGO:00459353320.246
catabolic processGO:00090564090.241
Human
small molecule metabolic processGO:00442813050.239
dna replicationGO:0006260480.238
Human
positive regulation of macroautophagyGO:001623980.233
regulation of cellular response to stressGO:0080135890.232
negative regulation of gene expression epigeneticGO:0045814770.230
immune system processGO:00023763470.227
regulation of immune system processGO:00026821760.215
columnar cuboidal epithelial cell differentiationGO:00020652560.215
programmed cell deathGO:00125012570.212
regulation of cellular protein metabolic processGO:00322682430.210
regulation of phosphate metabolic processGO:00192202100.205
regulation of double strand break repairGO:200077930.205
cellular protein modification processGO:00064644380.203
single organism biosynthetic processGO:00447112060.202
Human
peptidyl amino acid modificationGO:00181931050.200
negative regulation of programmed cell deathGO:0043069720.187
regulation of cell divisionGO:0051302720.184
regulation of phosphorus metabolic processGO:00511742100.183
apoptotic processGO:00069151590.183
dna biosynthetic processGO:0071897240.182
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.178
Human
regulation of meiosisGO:004002030.175
embryonic morphogenesisGO:00485982060.174
regulation of protein modification processGO:00313991120.172
negative regulation of signalingGO:00230572190.169
gene silencingGO:00164581380.166
protein modification processGO:00362114380.166
oocyte maturationGO:000155630.164
positive regulation of response to stimulusGO:00485843230.162
regulation of catalytic activityGO:00507901850.161
macromolecular complex assemblyGO:00650032560.161
Human
eye developmentGO:00016543230.156
nuclear dna replicationGO:003326010.152
Human
immune responseGO:00069552460.147
positive regulation of immune system processGO:0002684680.143
columnar cuboidal epithelial cell developmentGO:00020662490.140
negative regulation of apoptotic processGO:0043066630.137
regulation of apoptotic processGO:00429811300.131
regulation of protein acetylationGO:190198370.130
positive regulation of biosynthetic processGO:00098913160.126
regulation of molecular functionGO:00650092170.124
negative regulation of macromolecule biosynthetic processGO:00105582700.123
Human
epithelial cell developmentGO:00020642740.123
telomere maintenance via recombinationGO:000072210.116
cellular response to ionizing radiationGO:0071479150.116
regulation of cell developmentGO:00602842150.113
cell cycle g2 m phase transitionGO:0044839220.113
Human
phosphorylationGO:00163102940.113
cell agingGO:000756920.112
positive regulation of transcription dna templatedGO:00458932660.111
regulation of programmed cell deathGO:00430671520.111
regulation of cell differentiationGO:00455953020.108
negative regulation of dna metabolic processGO:0051053120.106
Human
immune response activating signal transductionGO:000275720.104
positive regulation of macromolecule biosynthetic processGO:00105572830.103
deathGO:00162652840.098
mitotic recombinationGO:000631220.095
positive regulation of nucleic acid templated transcriptionGO:19035082660.095
cellular response to radiationGO:0071478520.092
ethanolamine containing compound metabolic processGO:004243940.089
regulation of macroautophagyGO:0016241150.088
ovarian follicle cell developmentGO:00307072480.087
meiotic chromosome segregationGO:0045132590.086
Worm
nucleoside triphosphate catabolic processGO:00091431080.085
epithelial cell differentiationGO:00308553220.085
positive regulation of immune responseGO:0050778630.083
positive regulation of rna metabolic processGO:00512542710.082
chorion containing eggshell formationGO:00073041050.082
cellular response to external stimulusGO:0071496660.081
spermatogenesisGO:00072832000.080
negative regulation of cellular protein metabolic processGO:0032269850.080
regulation of organelle organizationGO:00330431960.078
cell deathGO:00082192790.077
organelle localizationGO:00516401480.077
establishment of localization in cellGO:00516494020.075
regulation of transferase activityGO:0051338580.074
response to x rayGO:001016580.074
negative regulation of cell deathGO:0060548810.074
negative regulation of rna biosynthetic processGO:19026792400.072
spindle organizationGO:00070512530.070
Human
regulation of growthGO:00400082330.070
negative regulation of g2 m transition of mitotic cell cycleGO:001097280.068
negative regulation of response to stimulusGO:00485852580.068
negative regulation of phosphate metabolic processGO:0045936450.067
regulation of nervous system developmentGO:00519602480.066
growthGO:00400073590.065
response to endogenous stimulusGO:00097191190.065
response to nitrogen compoundGO:1901698900.065
regionalizationGO:00030024160.065
cell maturationGO:00484691440.065
mitotic nuclear divisionGO:00070672130.064
Human
negative regulation of meiotic cell cycleGO:005144720.063
regulation of developmental growthGO:00486381740.062
positive regulation of cysteine type endopeptidase activityGO:2001056240.061
organelle assemblyGO:00709251980.060
Human
protein complex assemblyGO:00064612000.060
Human
intracellular signal transductionGO:00355563000.059
telencephalon developmentGO:002153720.059
mitochondrion organizationGO:0007005650.059
positive regulation of peptidase activityGO:0010952290.058
sensory organ morphogenesisGO:00905962600.058
histone modificationGO:00165701060.057
cellular response to endogenous stimulusGO:0071495800.057
positive regulation of histone acetylationGO:003506630.056
negative regulation of rna metabolic processGO:00512532510.055
notch signaling pathwayGO:00072191200.053
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.053
immune response regulating signaling pathwayGO:000276420.052
negative regulation of cell differentiationGO:00455961430.052
neural precursor cell proliferationGO:0061351750.052
intracellular mrna localizationGO:0008298660.052
developmental maturationGO:00217001720.052
regulation of phosphorylationGO:00423251470.051
positive regulation of response to extracellular stimulusGO:003210680.049
negative regulation of cell communicationGO:00106482230.048
chromatin silencingGO:0006342760.048
heterocycle catabolic processGO:00467001660.048
response to oxygen containing compoundGO:19017002000.047
regulation of proteolysisGO:0030162870.047
g2 m transition of mitotic cell cycleGO:0000086190.046
Human
autophagyGO:00069141080.045
cellular response to chemical stimulusGO:00708871990.045
cellular response to oxygen containing compoundGO:1901701790.044
chromosome segregationGO:00070591570.043
Worm
mitotic cell cycle embryonicGO:0045448380.043
dna methylation or demethylationGO:004472840.042
ion transportGO:00068111450.042
cellular macromolecule localizationGO:00707272200.041
negative regulation of signal transductionGO:00099682060.041
signal transduction in response to dna damageGO:004277030.041
Human Mouse
female meiosis chromosome segregationGO:0016321330.040
nucleobase containing compound catabolic processGO:00346551650.039
regulation of cellular catabolic processGO:00313291570.039
response to organonitrogen compoundGO:0010243750.038
response to other organismGO:00517072930.037
regulation of protein kinase activityGO:0045859510.036
cellular response to extracellular stimulusGO:0031668640.036
negative regulation of multicellular organismal processGO:00512411420.035
regulation of cell deathGO:00109411730.035
negative regulation of nucleic acid templated transcriptionGO:19035072400.035
compound eye morphogenesisGO:00017452490.034
negative regulation of phosphorylationGO:0042326350.034
cytoplasm organizationGO:0007028640.033
cellular macromolecule catabolic processGO:00442651360.032
Human
stem cell divisionGO:0017145690.032
amine metabolic processGO:0009308120.032
protein phosphorylationGO:00064681690.031
renal system developmentGO:0072001720.031
regulation of protein phosphorylationGO:0001932640.031
regulation of cysteine type endopeptidase activityGO:2000116270.031
enzyme linked receptor protein signaling pathwayGO:00071671790.031
cellular nitrogen compound catabolic processGO:00442701650.030
response to organic cyclic compoundGO:0014070890.030
cell motilityGO:00488702510.030
proteolysisGO:00065081920.030
negative regulation of cell cycle g2 m phase transitionGO:190275080.030
dna catabolic processGO:0006308160.029
protein import into nucleusGO:0006606510.029
positive regulation of gene expressionGO:00106282900.029
intrinsic apoptotic signaling pathwayGO:0097193160.028
aromatic compound catabolic processGO:00194391660.028
positive regulation of developmental processGO:00510941430.028
protein localizationGO:00081042840.028
response to biotic stimulusGO:00096072940.028
dorsal ventral pattern formationGO:00099531330.028
regulation of gene silencingGO:0060968630.028
cellular response to nitrogen compoundGO:1901699510.027
negative regulation of growthGO:0045926840.027
protein processingGO:0016485680.027
signal transduction by phosphorylationGO:00230141070.027
single organism catabolic processGO:00447122280.027
regulation of hydrolase activityGO:0051336970.027
regulation of cyclin dependent protein serine threonine kinase activityGO:000007930.027
regulation of protein serine threonine kinase activityGO:0071900250.026
camera type eye morphogenesisGO:004859320.026
covalent chromatin modificationGO:00165691060.026
regulation of nuclear divisionGO:0051783580.025
vesicle mediated transportGO:00161923810.025
compound eye photoreceptor cell differentiationGO:00017511400.025
immune system developmentGO:0002520570.025
protein dna complex subunit organizationGO:0071824860.024
dna packagingGO:0006323910.024
positive regulation of cell communicationGO:00106472500.024
germarium derived egg chamber formationGO:00072931010.024
regulation of immune responseGO:00507761180.024
negative regulation of nervous system developmentGO:0051961920.024
chromosome separationGO:0051304420.024
negative regulation of catalytic activityGO:0043086420.023
cellular amine metabolic processGO:0044106120.023
neuroblast proliferationGO:0007405740.023
stem cell proliferationGO:0072089880.022
carboxylic acid metabolic processGO:0019752920.022
photoreceptor cell differentiationGO:00465301700.022
meiotic chromosome separationGO:005130780.022
protein alkylationGO:0008213430.021
cellular ketone metabolic processGO:0042180240.021
protein transportGO:00150311550.021
germarium derived female germ line cyst formationGO:0030727420.021
developmental growthGO:00485892800.021
zymogen activationGO:0031638200.021
regulation of neurogenesisGO:00507671580.021
regulation of kinase activityGO:0043549530.021
organic acid metabolic processGO:00060821030.021
cellular amino acid metabolic processGO:0006520610.021
regulation of cellular ketone metabolic processGO:001056530.020
regulation of defense responseGO:00313471020.020
regulation of meiotic cell cycleGO:005144590.020
macromolecule methylationGO:0043414450.020
cellular response to hormone stimulusGO:0032870440.020
regulation of hemocyte proliferationGO:0035206370.020
positive regulation of multicellular organismal processGO:00512401430.019
histone h3 k9 acetylationGO:004397030.019
negative regulation of phosphorus metabolic processGO:0010563450.019
muscle structure developmentGO:00610612240.019
regulation of localizationGO:00328792750.019
dna amplificationGO:0006277110.019
oxoacid metabolic processGO:00434361030.018
regulation of cellular amino acid metabolic processGO:000652100.018
organophosphate metabolic processGO:00196371950.018
negative regulation of transcription from rna polymerase ii promoterGO:00001221190.018
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280230.018
positive regulation of endopeptidase activityGO:0010950260.018
eye morphogenesisGO:00485922600.018
nuclear importGO:0051170510.018
respiratory system developmentGO:00605412130.018
tube developmentGO:00352952440.018
regulation of cell substrate adhesionGO:001081020.018
sister chromatid cohesionGO:0007062180.018
regulation of response to extracellular stimulusGO:0032104180.018
cellular response to peptide hormone stimulusGO:0071375280.018
regulation of endopeptidase activityGO:0052548360.017
regulation of peptidase activityGO:0052547390.017
reproductive system developmentGO:0061458740.017
negative regulation of dna recombinationGO:004591020.017
negative regulation of oskar mrna translationGO:000731950.017
activation of cysteine type endopeptidase activityGO:0097202170.017
negative regulation of chromatin silencingGO:003193690.017
positive regulation of signalingGO:00230562430.017
regulation of mitosisGO:0007088560.017
smoothened signaling pathwayGO:0007224490.017
organic substance catabolic processGO:19015753080.017
Human
mitotic sister chromatid segregationGO:0000070870.017
ribonucleoside triphosphate metabolic processGO:00091991190.017
positive regulation of cellular amino acid metabolic processGO:004576400.017
stem cell differentiationGO:00488631170.017
regulation of catabolic processGO:00098941700.016
Human
response to inorganic substanceGO:0010035440.016
macromolecule catabolic processGO:00090571610.016
Human
negative regulation of cell divisionGO:0051782170.016
female germ line cyst formationGO:0048135420.016
g1 s transition of mitotic cell cycleGO:0000082310.016
positive regulation of cell developmentGO:0010720610.016
cellular response to light stimulusGO:0071482370.016
central nervous system developmentGO:00074172010.016
negative regulation of developmental growthGO:0048640640.015
cellular response to organonitrogen compoundGO:0071417360.015
meiotic dna double strand break processingGO:000070630.015
regulation of nucleocytoplasmic transportGO:0046822350.015
phagocytosisGO:00069092150.015
protein targeting to nucleusGO:0044744510.015
body morphogenesisGO:001017120.014
cellular response to biotic stimulusGO:007121640.014
regulation of smoothened signaling pathwayGO:0008589280.014
macroautophagyGO:0016236420.014
single organism intracellular transportGO:19025822070.014
nucleocytoplasmic transportGO:0006913720.014
innate immune responseGO:00450871440.014
regulation of g2 m transition of mitotic cell cycleGO:0010389150.014
cellular response to organic cyclic compoundGO:0071407320.014
regulation of protein transportGO:0051223570.013
transcription elongation from rna polymerase ii promoterGO:0006368180.013
nuclear transportGO:0051169720.013
regulation of epithelial cell proliferationGO:005067840.013
heart developmentGO:0007507820.013
defense response to other organismGO:00985422250.013
organic substance transportGO:00717022570.013
retina development in camera type eyeGO:006004140.013
regulation of chromatin silencingGO:0031935360.013
positive regulation of proteolysisGO:0045862520.013
positive regulation of catalytic activityGO:00430851180.013
positive regulation of cell sizeGO:0045793210.013
nucleoside metabolic processGO:00091161270.013
pronuclear migrationGO:003504640.013
positive regulation of cellular amine metabolic processGO:003324000.012
response to insulinGO:0032868290.012
maintenance of locationGO:0051235730.012
single organism behaviorGO:00447083910.012
response to alcoholGO:0097305950.012
positive regulation of cell cycleGO:0045787430.012
forebrain developmentGO:003090020.012
dna dependent dna replicationGO:0006261170.012
Human
connective tissue developmentGO:006144830.012
protein localization to nucleusGO:0034504550.012
internal peptidyl lysine acetylationGO:0018393380.011
immune effector processGO:0002252980.011
positive regulation of innate immune responseGO:0045089380.011
intracellular transportGO:00469072280.011
dendrite developmentGO:00163582040.011
compound eye developmentGO:00487493070.011
response to virusGO:0009615280.011
positive regulation of defense responseGO:0031349590.011
male pronucleus assemblyGO:003503960.011
regulation of intracellular signal transductionGO:19025312360.011
positive regulation of histone deacetylationGO:003106520.011
larval developmentGO:00021641040.011
cytoplasmic transportGO:00164821300.011
cell type specific apoptotic processGO:0097285380.011
regulation of response to biotic stimulusGO:0002831630.011
purine nucleotide metabolic processGO:00061631460.010
regulation of intracellular protein transportGO:0033157460.010
oocyte fate determinationGO:0030716270.010
purine nucleoside triphosphate catabolic processGO:00091461080.010
organic cyclic compound catabolic processGO:19013611680.010
ribonucleotide metabolic processGO:00092591450.010
positive regulation of organelle organizationGO:0010638650.010
regulation of protein export from nucleusGO:004682530.010
positive regulation of gene expression epigeneticGO:0045815160.010
regulation of transcription by chromatin organizationGO:003440130.010
activation of jun kinase activityGO:000725730.010
positive regulation of nervous system developmentGO:0051962690.010
negative regulation of intracellular signal transductionGO:1902532570.010
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.010
response to hormoneGO:0009725450.010

lok disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:1456600.038
Human
organ system cancerDOID:005068600.038
Human
cancerDOID:16200.038
Human
thoracic cancerDOID:509300.019
Human
disease of anatomical entityDOID:700.019