IMP: Integrative Multi-species Prediction

Drosophila melanogaster

188 known processes

mts (Dmel_CG7109)

microtubule star

(Aliases: PP2A 28D,MTS/PP2A,PP2A[[C]],PP2Ac,l(2)s5286,PP2a 28D,dPP2A,Mts,PP2A C,l(2)02496,PP2a,Pp2A,PP2,Dmel\CG7109,PP2A,DmPp2A-28D,CG7109,5559,PP2A-C,Pp2A-28D,ER2-6)

Entrez: 45959
FLYBASE: FBgn0004177
UniProtKB: P23696
UniProtKB: X2JDI1

Process Predictions
Disease Predictions

mts biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
negative regulation of gene expression	GO:0010629	387	0.915	Rat
organelle fission	GO:0048285	340	0.784
regulation of cellular protein metabolic process	GO:0032268	243	0.782	Human Rat
positive regulation of cellular protein metabolic process	GO:0032270	118	0.757	Human Rat
imaginal disc derived appendage development	GO:0048737	399	0.735
negative regulation of cellular metabolic process	GO:0031324	382	0.691	Rat
regulation of protein metabolic process	GO:0051246	256	0.679	Human Rat
regulation of cellular catabolic process	GO:0031329	157	0.664
regulation of catabolic process	GO:0009894	170	0.655	Rat
regulation of intracellular signal transduction	GO:1902531	236	0.563	Rat
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.555	Rat
actin filament based process	GO:0030029	220	0.527
death	GO:0016265	284	0.517	Mouse Rat
determination of adult lifespan	GO:0008340	137	0.507
positive regulation of catabolic process	GO:0009896	105	0.488
establishment of localization in cell	GO:0051649	402	0.475	Rat
homeostatic process	GO:0042592	199	0.463	Rat
intracellular transport	GO:0046907	228	0.451	Rat
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.423
regulation of molecular function	GO:0065009	217	0.401
protein modification process	GO:0036211	438	0.367
dendrite morphogenesis	GO:0048813	199	0.359
asymmetric neuroblast division	GO:0055059	33	0.351
spindle organization	GO:0007051	253	0.348
single organism intracellular transport	GO:1902582	207	0.336	Rat
negative regulation of cellular biosynthetic process	GO:0031327	277	0.327	Rat
cellular catabolic process	GO:0044248	372	0.327
appendage morphogenesis	GO:0035107	397	0.306
cellular homeostasis	GO:0019725	80	0.284	Rat
regulation of gene expression epigenetic	GO:0040029	128	0.276
cell death	GO:0008219	279	0.275	Mouse Rat
ubiquitin dependent protein catabolic process	GO:0006511	78	0.271	Mouse
regulation of cell cycle	GO:0051726	291	0.270
cell cycle phase transition	GO:0044770	140	0.266
imaginal disc derived wing morphogenesis	GO:0007476	337	0.263
axonogenesis	GO:0007409	290	0.251
endocytosis	GO:0006897	310	0.246
compound eye morphogenesis	GO:0001745	249	0.245
neuroblast division	GO:0055057	35	0.243
mitotic spindle organization	GO:0007052	220	0.237	Worm
gene silencing by rna	GO:0031047	57	0.237
protein localization	GO:0008104	284	0.229	Rat
apoptotic cell clearance	GO:0043277	14	0.227
dendrite development	GO:0016358	204	0.225
regulation of proteolysis	GO:0030162	87	0.219	Rat
regulation of cytoskeleton organization	GO:0051493	89	0.212
positive regulation of proteolysis	GO:0045862	52	0.207	Rat
regulation of nervous system development	GO:0051960	248	0.207
membrane invagination	GO:0010324	11	0.203
cellular protein modification process	GO:0006464	438	0.202
posttranscriptional gene silencing by rna	GO:0035194	45	0.201
gene silencing	GO:0016458	138	0.199
cell division	GO:0051301	248	0.196
non sensory hair organization	GO:0035316	47	0.190
regulation of phosphate metabolic process	GO:0019220	210	0.189	Human Rat
positive regulation of molecular function	GO:0044093	136	0.180	Human Rat
oocyte microtubule cytoskeleton organization	GO:0016325	35	0.178
nuclear division	GO:0000280	332	0.173
regulation of hydrolase activity	GO:0051336	97	0.173	Rat
tissue morphogenesis	GO:0048729	297	0.172
developmental growth	GO:0048589	280	0.169
canonical wnt signaling pathway	GO:0060070	21	0.167
protein polymerization	GO:0051258	42	0.162
vesicle mediated transport	GO:0016192	381	0.162
embryonic morphogenesis	GO:0048598	206	0.161
meiotic cell cycle	GO:0051321	171	0.157	Worm
ras protein signal transduction	GO:0007265	88	0.156	Rat
locomotory behavior	GO:0007626	176	0.156
proteolysis	GO:0006508	192	0.155	Mouse Rat
negative regulation of signal transduction	GO:0009968	206	0.154	Rat
imaginal disc derived wing hair site selection	GO:0035320	4	0.151
compound eye development	GO:0048749	307	0.150
regulation of catalytic activity	GO:0050790	185	0.146
positive regulation of cellular component organization	GO:0051130	156	0.145
establishment of imaginal disc derived wing hair orientation	GO:0001737	24	0.145
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.144	Rat
positive regulation of cellular catabolic process	GO:0031331	95	0.141
synapse organization	GO:0050808	196	0.139
negative regulation of cellular protein metabolic process	GO:0032269	85	0.136	Rat
posttranscriptional gene silencing	GO:0016441	46	0.133
cellular protein complex assembly	GO:0043623	71	0.133
positive regulation of protein metabolic process	GO:0051247	128	0.125	Human Rat
positive regulation of phosphate metabolic process	GO:0045937	139	0.116	Human Rat
single organism cellular localization	GO:1902580	180	0.116	Rat
meiotic spindle organization	GO:0000212	36	0.115	Worm
regulation of actin cytoskeleton organization	GO:0032956	42	0.111
cellular response to dna damage stimulus	GO:0006974	223	0.109
macromolecular complex assembly	GO:0065003	256	0.109
central nervous system development	GO:0007417	201	0.107
negative regulation of cell communication	GO:0010648	223	0.106	Rat
establishment of cell polarity	GO:0030010	40	0.105
regulation of protein modification process	GO:0031399	112	0.105	Human Rat
intracellular signal transduction	GO:0035556	300	0.102	Rat
intracellular protein transport	GO:0006886	104	0.101	Rat
regulation of mitotic cell cycle	GO:0007346	190	0.100
cortical cytoskeleton organization	GO:0030865	29	0.100
regulation of protein catabolic process	GO:0042176	55	0.096	Rat
appendage development	GO:0048736	401	0.092
regulation of multicellular organismal development	GO:2000026	414	0.090
positive regulation of phosphorylation	GO:0042327	87	0.090	Human
actin cytoskeleton organization	GO:0030036	206	0.089
circulatory system development	GO:0072359	82	0.085	Rat
regulation of organelle organization	GO:0033043	196	0.085
gland development	GO:0048732	191	0.084
guanosine containing compound metabolic process	GO:1901068	74	0.084
mapk cascade	GO:0000165	107	0.083
post embryonic appendage morphogenesis	GO:0035120	385	0.083
immune system development	GO:0002520	57	0.083
cellular macromolecule localization	GO:0070727	220	0.081	Rat
regulation of phosphorus metabolic process	GO:0051174	210	0.081	Human Rat
negative regulation of rna biosynthetic process	GO:1902679	240	0.080	Rat
chromosome segregation	GO:0007059	157	0.079
neuroblast proliferation	GO:0007405	74	0.079
cell motility	GO:0048870	251	0.078
regulation of localization	GO:0032879	275	0.077	Rat
hair cell differentiation	GO:0035315	47	0.076
mitotic cell cycle phase transition	GO:0044772	138	0.076
phagocytosis	GO:0006909	215	0.074
regulation of purine nucleotide catabolic process	GO:0033121	48	0.070
small gtpase mediated signal transduction	GO:0007264	88	0.069	Rat
aging	GO:0007568	143	0.069
multicellular organismal aging	GO:0010259	140	0.067
modification dependent macromolecule catabolic process	GO:0043632	79	0.067	Mouse
regulation of dendrite morphogenesis	GO:0048814	28	0.065
notch signaling pathway	GO:0007219	120	0.065
positive regulation of phosphorus metabolic process	GO:0010562	139	0.065	Human Rat
membrane organization	GO:0061024	112	0.062	Worm
embryo development ending in birth or egg hatching	GO:0009792	152	0.062	Worm
regulation of cell cycle process	GO:0010564	181	0.062
neuron recognition	GO:0008038	101	0.062
apoptotic process	GO:0006915	159	0.061	Mouse Rat
gtp metabolic process	GO:0046039	72	0.059
response to extracellular stimulus	GO:0009991	116	0.059
intracellular mrna localization involved in pattern specification process	GO:0060810	56	0.058
regulation of protein polymerization	GO:0032271	28	0.058
chromosome organization	GO:0051276	360	0.057
regulation of phosphatase activity	GO:0010921	3	0.056	Rat
modification dependent protein catabolic process	GO:0019941	78	0.056	Mouse
proteasomal protein catabolic process	GO:0010498	59	0.056	Mouse
positive regulation of developmental process	GO:0051094	143	0.055	Worm
establishment of planar polarity	GO:0001736	87	0.055
cellular response to extracellular stimulus	GO:0031668	64	0.055
protein complex assembly	GO:0006461	200	0.054
salivary gland morphogenesis	GO:0007435	145	0.053
axon development	GO:0061564	297	0.053
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.053
establishment or maintenance of cell polarity	GO:0007163	167	0.053
oocyte microtubule cytoskeleton polarization	GO:0008103	22	0.052
cellular macromolecular complex assembly	GO:0034622	153	0.051
dorsal ventral pattern formation	GO:0009953	133	0.051
regulation of anatomical structure morphogenesis	GO:0022603	242	0.051
regulation of actin filament length	GO:0030832	27	0.050
regulation of actin polymerization or depolymerization	GO:0008064	27	0.050
positive regulation of cell communication	GO:0010647	250	0.050
positive regulation of response to stimulus	GO:0048584	323	0.049
cellular response to organic substance	GO:0071310	132	0.049	Rat
pole plasm assembly	GO:0007315	61	0.048
autophagic vacuole assembly	GO:0000045	2	0.047
protein maturation	GO:0051604	71	0.047
positive regulation of cell proliferation	GO:0008284	47	0.046
protein k48 linked ubiquitination	GO:0070936	3	0.045
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.043
actin polymerization or depolymerization	GO:0008154	31	0.043
cellular protein localization	GO:0034613	160	0.043	Rat
regulation of gtpase activity	GO:0043087	44	0.043
digestive system development	GO:0055123	149	0.043
wing disc morphogenesis	GO:0007472	344	0.043
notch receptor processing	GO:0007220	13	0.042
regulation of endopeptidase activity	GO:0052548	36	0.042	Rat
lipid localization	GO:0010876	54	0.042
phagocytosis engulfment	GO:0006911	11	0.041
single organism behavior	GO:0044708	391	0.041
asymmetric stem cell division	GO:0098722	49	0.041
germarium derived female germ line cyst formation	GO:0030727	42	0.041
cell proliferation	GO:0008283	299	0.040
regulation of notch signaling pathway	GO:0008593	100	0.040
regulation of cellular protein catabolic process	GO:1903362	44	0.038
regulation of cell development	GO:0060284	215	0.037
catabolic process	GO:0009056	409	0.037
dephosphorylation	GO:0016311	51	0.037
morphogenesis of a polarized epithelium	GO:0001738	93	0.036
actin filament organization	GO:0007015	126	0.036
epidermis development	GO:0008544	65	0.036
positive regulation of proteasomal protein catabolic process	GO:1901800	20	0.035
trna modification	GO:0006400	2	0.034
organophosphate biosynthetic process	GO:0090407	46	0.034
cellular response to endogenous stimulus	GO:0071495	80	0.034	Rat
exocrine system development	GO:0035272	162	0.034
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.033
establishment of monopolar cell polarity	GO:0061162	15	0.033
synapse assembly	GO:0007416	143	0.033
positive regulation of protein polymerization	GO:0032273	14	0.033
negative regulation of protein metabolic process	GO:0051248	85	0.033	Rat
regulation of microtubule based process	GO:0032886	49	0.032
rhythmic process	GO:0048511	106	0.032
establishment of mitotic spindle localization	GO:0040001	17	0.032
organophosphate catabolic process	GO:0046434	112	0.031
regulation of gene silencing	GO:0060968	63	0.031
posttranscriptional regulation of gene expression	GO:0010608	145	0.031
glycosyl compound metabolic process	GO:1901657	127	0.030
negative regulation of catalytic activity	GO:0043086	42	0.030
head development	GO:0060322	135	0.030
meiotic nuclear division	GO:0007126	151	0.030
negative regulation of molecular function	GO:0044092	51	0.030	Rat
regulation of cell differentiation	GO:0045595	302	0.029
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.029
intrinsic apoptotic signaling pathway in response to dna damage	GO:0008630	11	0.029
chemotaxis	GO:0006935	249	0.029
regulation of meiosis	GO:0040020	3	0.028
ribonucleotide catabolic process	GO:0009261	109	0.028
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.028
brain development	GO:0007420	120	0.028
generation of precursor metabolites and energy	GO:0006091	42	0.028
immune system process	GO:0002376	347	0.028
establishment of proximal distal cell polarity	GO:0022606	4	0.028
stem cell proliferation	GO:0072089	88	0.027
anterior posterior axis specification embryo	GO:0008595	103	0.027
cortical actin cytoskeleton organization	GO:0030866	24	0.027
cellular response to organonitrogen compound	GO:0071417	36	0.027	Rat
regulation of ras protein signal transduction	GO:0046578	93	0.027	Rat
regulation of protein phosphorylation	GO:0001932	64	0.026	Human Rat
positive regulation of gene expression	GO:0010628	290	0.025
dna damage checkpoint	GO:0000077	78	0.025
axon guidance	GO:0007411	233	0.025
oocyte development	GO:0048599	124	0.025
anterior posterior pattern specification	GO:0009952	136	0.025
regulation of microtubule cytoskeleton organization	GO:0070507	41	0.025
regulation of protein complex assembly	GO:0043254	42	0.024
tissue death	GO:0016271	102	0.024
regulation of endocytosis	GO:0030100	37	0.024
establishment of organelle localization	GO:0051656	122	0.024
taxis	GO:0042330	304	0.023
neuron projection guidance	GO:0097485	241	0.023
eye development	GO:0001654	323	0.023
establishment of spindle orientation	GO:0051294	18	0.023
regulation of cell shape	GO:0008360	113	0.023
nucleotide metabolic process	GO:0009117	161	0.023
purine containing compound metabolic process	GO:0072521	155	0.023
gland morphogenesis	GO:0022612	145	0.023
long term memory	GO:0007616	62	0.022
microtubule based movement	GO:0007018	51	0.022
macromolecule catabolic process	GO:0009057	161	0.022	Mouse Rat
regulation of anatomical structure size	GO:0090066	163	0.022
muscle structure development	GO:0061061	224	0.022
mitotic nuclear division	GO:0007067	213	0.022
regulation of cell cycle phase transition	GO:1901987	130	0.022
regulation of actin filament polymerization	GO:0030833	25	0.022
morphogenesis of embryonic epithelium	GO:0016331	94	0.022
oocyte axis specification	GO:0007309	108	0.021
regulation of proteasomal protein catabolic process	GO:0061136	39	0.021
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.021	Rat
programmed cell death	GO:0012501	257	0.021	Mouse Rat
positive regulation of cell migration	GO:0030335	2	0.021
organophosphate metabolic process	GO:0019637	195	0.021
imaginal disc derived wing hair organization	GO:0035317	45	0.020
establishment of mitotic spindle orientation	GO:0000132	13	0.020
macromolecular complex disassembly	GO:0032984	37	0.020	Worm
negative regulation of proteolysis	GO:0045861	31	0.020
regulation of cell division	GO:0051302	72	0.020
regulation of gtp catabolic process	GO:0033124	44	0.020
mitotic cell cycle embryonic	GO:0045448	38	0.019
positive regulation of organelle organization	GO:0010638	65	0.019
gtp catabolic process	GO:0006184	72	0.019
response to other organism	GO:0051707	293	0.019
purine containing compound catabolic process	GO:0072523	112	0.019
phosphorylation	GO:0016310	294	0.019	Human Rat
regulation of cellular component biogenesis	GO:0044087	201	0.019
hematopoietic or lymphoid organ development	GO:0048534	57	0.019
regulation of purine nucleotide metabolic process	GO:1900542	62	0.019
localization of cell	GO:0051674	257	0.019
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.018	Rat
establishment of spindle localization	GO:0051293	22	0.018
regionalization	GO:0003002	416	0.018
attachment of spindle microtubules to kinetochore	GO:0008608	5	0.018
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.018	Mouse
positive regulation of cell differentiation	GO:0045597	64	0.018
protein catabolic process	GO:0030163	101	0.018	Mouse Rat
positive regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032436	19	0.018
purine nucleoside metabolic process	GO:0042278	127	0.018
response to nutrient levels	GO:0031667	114	0.017
negative regulation of phosphorus metabolic process	GO:0010563	45	0.017	Rat
imaginal disc growth	GO:0007446	37	0.017
actin filament polymerization	GO:0030041	27	0.017
carbohydrate derivative metabolic process	GO:1901135	217	0.017
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.017
regulation of cell death	GO:0010941	173	0.017	Rat
regulation of protein serine threonine kinase activity	GO:0071900	25	0.017	Human
protein processing	GO:0016485	68	0.016
regulation of transport	GO:0051049	181	0.016	Rat
response to organic substance	GO:0010033	284	0.016	Rat
regulation of nuclear division	GO:0051783	58	0.016
skeletal muscle organ development	GO:0060538	48	0.016
somatic stem cell division	GO:0048103	37	0.016
hemocyte differentiation	GO:0042386	38	0.016
neuromuscular process	GO:0050905	21	0.016
regulation of mapk cascade	GO:0043408	92	0.016
regulation of mitotic sister chromatid segregation	GO:0033047	28	0.016
positive regulation of proteolysis involved in cellular protein catabolic process	GO:1903052	24	0.015
rna interference	GO:0016246	27	0.015
positive regulation of programmed cell death	GO:0043068	62	0.015	Rat
regulation of organ morphogenesis	GO:2000027	78	0.015
germ line cyst formation	GO:0048134	44	0.015
cellular macromolecule catabolic process	GO:0044265	136	0.015	Mouse
muscle organ development	GO:0007517	127	0.015
regulation of synapse structure and activity	GO:0050803	128	0.015
mrna 3 end processing	GO:0031124	28	0.015
regulation of system process	GO:0044057	36	0.015
regulation of cell proliferation	GO:0042127	163	0.015
microtubule organizing center organization	GO:0031023	168	0.014
single organism catabolic process	GO:0044712	228	0.014
single organism carbohydrate metabolic process	GO:0044723	72	0.014
organonitrogen compound metabolic process	GO:1901564	318	0.014
compound eye retinal cell programmed cell death	GO:0046667	23	0.014
cytoplasmic transport	GO:0016482	130	0.014	Rat
regulation of response to stress	GO:0080134	200	0.014
locomotor rhythm	GO:0045475	56	0.014
cellular chemical homeostasis	GO:0055082	40	0.013	Rat
establishment or maintenance of monopolar cell polarity	GO:0061339	15	0.013
encapsulation of foreign target	GO:0035010	38	0.013
cellular carbohydrate metabolic process	GO:0044262	22	0.013
regulation of protein dephosphorylation	GO:0035304	5	0.013	Rat
female germ line cyst formation	GO:0048135	42	0.013
positive regulation of hydrolase activity	GO:0051345	78	0.013	Rat
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.013
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.013	Rat
regulation of embryonic development	GO:0045995	68	0.013
organic cyclic compound catabolic process	GO:1901361	168	0.013
developmental programmed cell death	GO:0010623	138	0.013
regulation of protein deacetylation	GO:0090311	2	0.013
regulation of cell projection assembly	GO:0060491	30	0.013
mitotic sister chromatid segregation	GO:0000070	87	0.013
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.013
purine ribonucleotide metabolic process	GO:0009150	145	0.013
cellular metal ion homeostasis	GO:0006875	31	0.012
regulation of neuroblast proliferation	GO:1902692	34	0.012
salivary gland development	GO:0007431	162	0.012
heterocycle catabolic process	GO:0046700	166	0.012
blastoderm segmentation	GO:0007350	159	0.012
positive regulation of cell motility	GO:2000147	3	0.012
cellular protein catabolic process	GO:0044257	83	0.012	Mouse
engulfment of apoptotic cell	GO:0043652	6	0.012
regulation of protein export from nucleus	GO:0046825	3	0.012
positive regulation of catalytic activity	GO:0043085	118	0.012	Human Rat
positive regulation of macromolecule metabolic process	GO:0010604	405	0.012	Human Rat
embryonic development via the syncytial blastoderm	GO:0001700	148	0.012
erk1 and erk2 cascade	GO:0070371	39	0.012
regulation of nucleotide metabolic process	GO:0006140	62	0.012
stem cell division	GO:0017145	69	0.012
regulation of intracellular transport	GO:0032386	64	0.012	Rat
regulation of actin filament based process	GO:0032970	42	0.012
developmental maturation	GO:0021700	172	0.012
negative regulation of neurogenesis	GO:0050768	53	0.011
guanosine containing compound catabolic process	GO:1901069	74	0.011
cellular response to chemical stimulus	GO:0070887	199	0.011	Rat
detection of abiotic stimulus	GO:0009582	66	0.011
embryonic axis specification	GO:0000578	107	0.011
regulation of transferase activity	GO:0051338	58	0.011	Human
positive regulation of cell development	GO:0010720	61	0.011
positive regulation of signal transduction	GO:0009967	223	0.011
negative regulation of rna metabolic process	GO:0051253	251	0.011	Rat
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	41	0.011
vacuole organization	GO:0007033	8	0.011
regulation of cellular localization	GO:0060341	136	0.011	Rat
pole plasm oskar mrna localization	GO:0045451	46	0.011
autophagy	GO:0006914	108	0.011
skin development	GO:0043588	65	0.011
establishment or maintenance of cytoskeleton polarity	GO:0030952	44	0.011
wnt signaling pathway	GO:0016055	98	0.011
positive regulation of apoptotic process	GO:0043065	47	0.011	Rat
organelle localization	GO:0051640	148	0.011
purine ribonucleoside metabolic process	GO:0046128	127	0.011
photoreceptor cell development	GO:0042461	96	0.010
negative regulation of imaginal disc growth	GO:0045571	8	0.010
oocyte anterior posterior axis specification	GO:0007314	72	0.010
organic substance catabolic process	GO:1901575	308	0.010	Mouse Rat
defense response	GO:0006952	300	0.010
synaptic growth at neuromuscular junction	GO:0051124	119	0.010
positive regulation of neurogenesis	GO:0050769	41	0.010
nucleocytoplasmic transport	GO:0006913	72	0.010	Rat

mts disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.012
	nervous system disease	DOID:863	0	0.012

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