IMP: Integrative Multi-species Prediction

Drosophila melanogaster

27 known processes

Bro (Dmel_CG7960)

Brother

(Aliases: bro,Dmel\CG7960,CG7960,rpbeta1)

FLYBASE: FBgn0013755
Entrez: 38202
UniProtKB: Q24039

Process Predictions
Disease Predictions

Bro biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
appendage morphogenesis	GO:0035107	397	0.079
post embryonic appendage morphogenesis	GO:0035120	385	0.061
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.052
appendage development	GO:0048736	401	0.050
tube development	GO:0035295	244	0.049
dendrite morphogenesis	GO:0048813	199	0.044
eye development	GO:0001654	323	0.043
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.041
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.040
positive regulation of cellular biosynthetic process	GO:0031328	316	0.039
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.039
compound eye development	GO:0048749	307	0.039
photoreceptor cell differentiation	GO:0046530	170	0.038
compound eye morphogenesis	GO:0001745	249	0.038
regulation of immune system process	GO:0002682	176	0.037
embryonic morphogenesis	GO:0048598	206	0.037
tube morphogenesis	GO:0035239	191	0.036
ovarian follicle cell development	GO:0030707	248	0.035
neurological system process	GO:0050877	358	0.034
imaginal disc derived appendage development	GO:0048737	399	0.034
negative regulation of response to stimulus	GO:0048585	258	0.034
positive regulation of macromolecule metabolic process	GO:0010604	405	0.033
regulation of anatomical structure morphogenesis	GO:0022603	242	0.033
endocytosis	GO:0006897	310	0.033
catabolic process	GO:0009056	409	0.033
small molecule metabolic process	GO:0044281	305	0.032
axon development	GO:0061564	297	0.032
vesicle mediated transport	GO:0016192	381	0.032
cell division	GO:0051301	248	0.031
single organism behavior	GO:0044708	391	0.031
columnar cuboidal epithelial cell development	GO:0002066	249	0.031
gland development	GO:0048732	191	0.031
dendrite development	GO:0016358	204	0.030
imaginal disc derived wing morphogenesis	GO:0007476	337	0.030
cell proliferation	GO:0008283	299	0.030
negative regulation of signaling	GO:0023057	219	0.030
regionalization	GO:0003002	416	0.030
negative regulation of gene expression	GO:0010629	387	0.030
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.030
cell death	GO:0008219	279	0.029
protein modification process	GO:0036211	438	0.029
eye morphogenesis	GO:0048592	260	0.028
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.028
connective tissue development	GO:0061448	3	0.028
organonitrogen compound metabolic process	GO:1901564	318	0.028
regulation of cell cycle	GO:0051726	291	0.028
organic substance catabolic process	GO:1901575	308	0.027
wing disc morphogenesis	GO:0007472	344	0.027
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.026
negative regulation of signal transduction	GO:0009968	206	0.026
negative regulation of cellular biosynthetic process	GO:0031327	277	0.026
positive regulation of biosynthetic process	GO:0009891	316	0.026
embryonic development via the syncytial blastoderm	GO:0001700	148	0.025
sensory organ morphogenesis	GO:0090596	260	0.025
positive regulation of response to stimulus	GO:0048584	323	0.025
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.025
gastrulation involving germ band extension	GO:0010004	36	0.025
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.024
gastrulation with mouth forming first	GO:0001703	36	0.024
positive regulation of transcription dna templated	GO:0045893	266	0.024
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.023
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.023
tissue morphogenesis	GO:0048729	297	0.023
behavioral response to pain	GO:0048266	3	0.023
phagocytosis	GO:0006909	215	0.022
compound eye photoreceptor development	GO:0042051	78	0.022
epithelial cell development	GO:0002064	274	0.022
regulation of cell differentiation	GO:0045595	302	0.022
lateral inhibition	GO:0046331	206	0.021
transcription from rna polymerase ii promoter	GO:0006366	368	0.021
digestive tract development	GO:0048565	149	0.021
cellular protein modification process	GO:0006464	438	0.021
cellular catabolic process	GO:0044248	372	0.021
chemotaxis	GO:0006935	249	0.021
negative regulation of biosynthetic process	GO:0009890	277	0.021
camera type eye development	GO:0043010	4	0.021
carbohydrate derivative metabolic process	GO:1901135	217	0.020
negative regulation of cell communication	GO:0010648	223	0.020
spindle organization	GO:0007051	253	0.020
embryo development ending in birth or egg hatching	GO:0009792	152	0.020
oxoacid metabolic process	GO:0043436	103	0.020
organelle assembly	GO:0070925	198	0.020
response to oxygen containing compound	GO:1901700	200	0.020
axon guidance	GO:0007411	233	0.020
proteolysis	GO:0006508	192	0.020
synaptic transmission	GO:0007268	288	0.020
body morphogenesis	GO:0010171	2	0.020
cell migration	GO:0016477	238	0.020
regulation of cell proliferation	GO:0042127	163	0.020
regulation of cellular ketone metabolic process	GO:0010565	3	0.019
negative regulation of cellular metabolic process	GO:0031324	382	0.019
eye photoreceptor cell differentiation	GO:0001754	145	0.019
regulation of cell development	GO:0060284	215	0.019
amine metabolic process	GO:0009308	12	0.019
nuclear division	GO:0000280	332	0.019
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.019
salivary gland morphogenesis	GO:0007435	145	0.019
regulation of cellular protein metabolic process	GO:0032268	243	0.019
regulation of cellular amine metabolic process	GO:0033238	3	0.019
positive regulation of rna biosynthetic process	GO:1902680	266	0.019
taxis	GO:0042330	304	0.019
cellular response to organic substance	GO:0071310	132	0.019
programmed cell death	GO:0012501	257	0.019
positive regulation of signaling	GO:0023056	243	0.018
exocrine system development	GO:0035272	162	0.018
developmental programmed cell death	GO:0010623	138	0.018
forebrain development	GO:0030900	2	0.018
negative regulation of developmental process	GO:0051093	201	0.018
cellular component assembly involved in morphogenesis	GO:0010927	151	0.018
positive regulation of signal transduction	GO:0009967	223	0.018
negative regulation of rna metabolic process	GO:0051253	251	0.018
negative regulation of rna biosynthetic process	GO:1902679	240	0.018
chromosome organization	GO:0051276	360	0.018
photoreceptor cell development	GO:0042461	96	0.018
single organism catabolic process	GO:0044712	228	0.018
digestive tract morphogenesis	GO:0048546	127	0.018
carboxylic acid metabolic process	GO:0019752	92	0.018
cellular response to chemical stimulus	GO:0070887	199	0.018
ethanolamine containing compound metabolic process	GO:0042439	4	0.018
regulation of cell cycle process	GO:0010564	181	0.018
retina development in camera type eye	GO:0060041	4	0.018
immune system process	GO:0002376	347	0.018
morphogenesis of an epithelium	GO:0002009	276	0.017
regulation of organ morphogenesis	GO:2000027	78	0.017
positive regulation of cell migration	GO:0030335	2	0.017
smoothened signaling pathway	GO:0007224	49	0.017
actin cytoskeleton organization	GO:0030036	206	0.017
salivary gland development	GO:0007431	162	0.017
organic acid metabolic process	GO:0006082	103	0.017
compound eye photoreceptor cell differentiation	GO:0001751	140	0.017
regulation of protein metabolic process	GO:0051246	256	0.017
regulation of multicellular organismal development	GO:2000026	414	0.017
muscle cell differentiation	GO:0042692	103	0.017
organic substance transport	GO:0071702	257	0.017
muscle structure development	GO:0061061	224	0.017
positive regulation of rna metabolic process	GO:0051254	271	0.017
positive regulation of cellular protein metabolic process	GO:0032270	118	0.017
leg disc development	GO:0035218	92	0.017
segmentation	GO:0035282	207	0.017
muscle organ development	GO:0007517	127	0.017
organophosphate metabolic process	GO:0019637	195	0.016
regulation of mitotic cell cycle	GO:0007346	190	0.016
gland morphogenesis	GO:0022612	145	0.016
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.016
biological adhesion	GO:0022610	138	0.016
regulation of organelle organization	GO:0033043	196	0.016
hematopoietic progenitor cell differentiation	GO:0002244	1	0.016
response to abiotic stimulus	GO:0009628	341	0.016
cell motility	GO:0048870	251	0.016
establishment of localization in cell	GO:0051649	402	0.016
gastrulation	GO:0007369	70	0.016
developmental maturation	GO:0021700	172	0.016
cholesterol transport	GO:0030301	2	0.016
macromolecular complex assembly	GO:0065003	256	0.016
r7 cell differentiation	GO:0045466	43	0.016
positive regulation of protein metabolic process	GO:0051247	128	0.016
organelle fission	GO:0048285	340	0.016
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.015
actin filament organization	GO:0007015	126	0.015
cellular amine metabolic process	GO:0044106	12	0.015
single organism biosynthetic process	GO:0044711	206	0.015
phosphorylation	GO:0016310	294	0.015
cellular ketone metabolic process	GO:0042180	24	0.015
spermatogenesis	GO:0007283	200	0.015
positive regulation of gene expression	GO:0010628	290	0.015
regulation of intracellular signal transduction	GO:1902531	236	0.015
positive regulation of cell motility	GO:2000147	3	0.015
homeostatic process	GO:0042592	199	0.015
regulation of gene expression epigenetic	GO:0040029	128	0.015
axonogenesis	GO:0007409	290	0.015
macromolecule catabolic process	GO:0009057	161	0.015
ras protein signal transduction	GO:0007265	88	0.015
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.015
cellular homeostasis	GO:0019725	80	0.014
heterocycle catabolic process	GO:0046700	166	0.014
axis specification	GO:0009798	167	0.014
regulation of phosphorus metabolic process	GO:0051174	210	0.014
response to lipopolysaccharide	GO:0032496	4	0.014
digestive system development	GO:0055123	149	0.014
protein complex biogenesis	GO:0070271	201	0.014
regulation of nervous system development	GO:0051960	248	0.014
positive regulation of lipid storage	GO:0010884	4	0.014
dorsal ventral pattern formation	GO:0009953	133	0.014
localization of cell	GO:0051674	257	0.014
regulation of cellular amino acid metabolic process	GO:0006521	0	0.014
immune response activating signal transduction	GO:0002757	2	0.014
response to organophosphorus	GO:0046683	2	0.014
response to wounding	GO:0009611	94	0.014
limb development	GO:0060173	1	0.014
response to ecdysone	GO:0035075	34	0.014
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.014
dorsal closure	GO:0007391	79	0.014
organonitrogen compound biosynthetic process	GO:1901566	117	0.014
regulation of protein modification process	GO:0031399	112	0.014
regulation of neuron differentiation	GO:0045664	103	0.014
eye photoreceptor cell development	GO:0042462	81	0.014
epithelial cell migration	GO:0010631	148	0.013
negative regulation of nervous system development	GO:0051961	92	0.013
cellular amino acid metabolic process	GO:0006520	61	0.013
endomembrane system organization	GO:0010256	119	0.013
salivary gland cell autophagic cell death	GO:0035071	83	0.013
intracellular signal transduction	GO:0035556	300	0.013
response to organic substance	GO:0010033	284	0.013
regulation of molecular function	GO:0065009	217	0.013
wnt signaling pathway	GO:0016055	98	0.013
response to copper ion	GO:0046688	4	0.013
sterol homeostasis	GO:0055092	4	0.013
developmental growth	GO:0048589	280	0.013
negative regulation of transcription dna templated	GO:0045892	237	0.013
cell maturation	GO:0048469	144	0.013
regulation of compound eye retinal cell programmed cell death	GO:0046669	18	0.013
regulation of apoptotic process	GO:0042981	130	0.013
organonitrogen compound catabolic process	GO:1901565	128	0.013
positive regulation of cell communication	GO:0010647	250	0.013
kidney development	GO:0001822	3	0.013
lipid metabolic process	GO:0006629	121	0.013
morphogenesis of a polarized epithelium	GO:0001738	93	0.013
negative regulation of cell differentiation	GO:0045596	143	0.013
mitotic spindle organization	GO:0007052	220	0.013
negative regulation of mitotic cell cycle	GO:0045930	109	0.013
eggshell formation	GO:0030703	105	0.013
hindbrain development	GO:0030902	2	0.013
cation transmembrane transport	GO:0098655	88	0.013
cholesterol homeostasis	GO:0042632	3	0.013
tissue migration	GO:0090130	155	0.013
nucleobase containing compound catabolic process	GO:0034655	165	0.013
mesenchymal cell development	GO:0014031	1	0.013
tissue death	GO:0016271	102	0.013
negative regulation of multicellular organismal process	GO:0051241	142	0.013
morphogenesis of embryonic epithelium	GO:0016331	94	0.013
regulation of localization	GO:0032879	275	0.012
telencephalon development	GO:0021537	2	0.012
intracellular transport	GO:0046907	228	0.012
death	GO:0016265	284	0.012
defense response	GO:0006952	300	0.012
chromosome segregation	GO:0007059	157	0.012
meiotic cell cycle	GO:0051321	171	0.012
malpighian tubule development	GO:0072002	64	0.012
anatomical structure homeostasis	GO:0060249	97	0.012
regulation of catalytic activity	GO:0050790	185	0.012
response to monosaccharide	GO:0034284	4	0.012
regulation of anatomical structure size	GO:0090066	163	0.012
carbohydrate derivative catabolic process	GO:1901136	118	0.012
protein complex assembly	GO:0006461	200	0.012
aromatic compound catabolic process	GO:0019439	166	0.012
chorion containing eggshell formation	GO:0007304	105	0.012
neuron projection guidance	GO:0097485	241	0.012
embryonic hindgut morphogenesis	GO:0048619	48	0.012
autophagic cell death	GO:0048102	83	0.012
cellular macromolecule catabolic process	GO:0044265	136	0.012
defense response to bacterium	GO:0042742	178	0.012
regulation of transport	GO:0051049	181	0.012
small gtpase mediated signal transduction	GO:0007264	88	0.012
regulation of cell death	GO:0010941	173	0.012
protein modification by small protein conjugation or removal	GO:0070647	106	0.012
male gamete generation	GO:0048232	201	0.012
wound healing	GO:0042060	75	0.012
cell adhesion	GO:0007155	136	0.012
positive regulation of molecular function	GO:0044093	136	0.012
defense response to other organism	GO:0098542	225	0.012
neuron recognition	GO:0008038	101	0.012
limb morphogenesis	GO:0035108	1	0.012
regulation of sequestering of triglyceride	GO:0010889	3	0.012
stem cell differentiation	GO:0048863	117	0.012
histolysis	GO:0007559	102	0.012
response to nutrient levels	GO:0031667	114	0.011
open tracheal system development	GO:0007424	204	0.011
gene silencing	GO:0016458	138	0.011
water homeostasis	GO:0030104	3	0.011
regulation of lipid transport	GO:0032368	3	0.011
posttranscriptional regulation of gene expression	GO:0010608	145	0.011
protein ubiquitination	GO:0016567	70	0.011
leg disc morphogenesis	GO:0007478	80	0.011
spinal cord development	GO:0021510	1	0.011
ameboidal type cell migration	GO:0001667	151	0.011
positive regulation of phosphorus metabolic process	GO:0010562	139	0.011
imaginal disc derived wing vein specification	GO:0007474	48	0.011
cell junction organization	GO:0034330	57	0.011
organophosphate catabolic process	GO:0046434	112	0.011
immune response regulating signaling pathway	GO:0002764	2	0.011
sensory perception of pain	GO:0019233	4	0.011
response to endogenous stimulus	GO:0009719	119	0.011
positive regulation of cellular amine metabolic process	GO:0033240	0	0.011
positive regulation of cellular component organization	GO:0051130	156	0.011
nucleobase containing small molecule metabolic process	GO:0055086	174	0.011
response to other organism	GO:0051707	293	0.011
regulation of cellular component size	GO:0032535	98	0.011
cellular response to dna damage stimulus	GO:0006974	223	0.011
cytoskeleton dependent cytokinesis	GO:0061640	81	0.011
purine ribonucleotide metabolic process	GO:0009150	145	0.011
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.011
g protein coupled receptor signaling pathway	GO:0007186	136	0.011
cellular macromolecule localization	GO:0070727	220	0.011
nucleoside phosphate metabolic process	GO:0006753	162	0.011
asymmetric stem cell division	GO:0098722	49	0.011
wing disc pattern formation	GO:0035222	66	0.011
growth	GO:0040007	359	0.011
organic cyclic compound catabolic process	GO:1901361	168	0.011
regulation of hydrolase activity	GO:0051336	97	0.011
negative regulation of cell cycle process	GO:0010948	109	0.011
central nervous system development	GO:0007417	201	0.011
purine nucleotide metabolic process	GO:0006163	146	0.011
imaginal disc derived leg morphogenesis	GO:0007480	80	0.011
protein maturation	GO:0051604	71	0.011
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.011
regulation of programmed cell death	GO:0043067	152	0.010
negative regulation of gene expression epigenetic	GO:0045814	77	0.010
cytokinesis	GO:0000910	90	0.010
formation of anatomical boundary	GO:0048859	37	0.010
maintenance of location	GO:0051235	73	0.010
negative regulation of cell cycle	GO:0045786	116	0.010
positive regulation of developmental process	GO:0051094	143	0.010
regulation of notch signaling pathway	GO:0008593	100	0.010
apoptotic process	GO:0006915	159	0.010
ribonucleotide catabolic process	GO:0009261	109	0.010
cellular response to molecule of bacterial origin	GO:0071219	3	0.010
single organism cellular localization	GO:1902580	180	0.010
synapse assembly	GO:0007416	143	0.010
epithelial cell differentiation	GO:0030855	322	0.010
regulation of developmental growth	GO:0048638	174	0.010
epithelial tube morphogenesis	GO:0060562	88	0.010
phospholipid homeostasis	GO:0055091	1	0.010
cellular response to biotic stimulus	GO:0071216	4	0.010
reproductive system development	GO:0061458	74	0.010
negative regulation of cell death	GO:0060548	81	0.010
hemocyte differentiation	GO:0042386	38	0.010
response to radiation	GO:0009314	155	0.010
single organism intracellular transport	GO:1902582	207	0.010
regulation of response to stress	GO:0080134	200	0.010
mesenchymal cell differentiation	GO:0048762	1	0.010
mrna metabolic process	GO:0016071	124	0.010
meiotic nuclear division	GO:0007126	151	0.010
cellular nitrogen compound catabolic process	GO:0044270	165	0.010
detection of stimulus	GO:0051606	156	0.010
positive regulation of programmed cell death	GO:0043068	62	0.010
stem cell division	GO:0017145	69	0.010
chromatin organization	GO:0006325	207	0.010

Bro disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.040
nervous system disease	DOID:863	0.022
disease of cellular proliferation	DOID:14566	0.018
organ system cancer	DOID:0050686	0.017
cancer	DOID:162	0.017
disease of metabolism	DOID:0014667	0.017
inherited metabolic disorder	DOID:655	0.015
sensory system disease	DOID:0050155	0.013
eye disease	DOID:5614	0.012
eye and adnexa disease	DOID:1492	0.012
acquired metabolic disease	DOID:0060158	0.011
glucose metabolism disease	DOID:4194	0.011
carbohydrate metabolism disease	DOID:0050013	0.011
diabetes mellitus	DOID:9351	0.011
cardiovascular system disease	DOID:1287	0.011

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