IMP: Integrative Multi-species Prediction

Drosophila melanogaster

62 known processes

Pp2A-29B (Dmel_CG17291)

Protein phosphatase 2A at 29B

(Aliases: Dmel\CG17291,CG13383,dPP2A A,A/PR65,Pp2A,PP2A,CG33297,PR65,PP2A-A,DPR65,CG17291,PP2A-29B)

Entrez: 2768940
FLYBASE: FBgn0260439
UniProtKB: P36179
UniProtKB: M9NDI6
UniProtKB: H5V8B8
UniProtKB: M9MQH9

Process Predictions
Disease Predictions

Pp2A-29B biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability
establishment of organelle localization	GO:0051656	122	0.982
mitotic cell cycle checkpoint	GO:0007093	88	0.872
cellular response to dna damage stimulus	GO:0006974	223	0.740
dna damage checkpoint	GO:0000077	78	0.738
nuclear division	GO:0000280	332	0.731
organelle fission	GO:0048285	340	0.724
cell division	GO:0051301	248	0.712
cell cycle checkpoint	GO:0000075	95	0.711
embryo development ending in birth or egg hatching	GO:0009792	152	0.703
synaptic transmission	GO:0007268	288	0.698
negative regulation of cell cycle process	GO:0010948	109	0.674
single organism cellular localization	GO:1902580	180	0.653
establishment of localization in cell	GO:0051649	402	0.531
protein localization	GO:0008104	284	0.530
cellular protein localization	GO:0034613	160	0.525
mitotic nuclear division	GO:0007067	213	0.487
regulation of cell cycle	GO:0051726	291	0.478
protein complex biogenesis	GO:0070271	201	0.463
negative regulation of cell cycle phase transition	GO:1901988	103	0.457
cellular macromolecular complex assembly	GO:0034622	153	0.448
macromolecular complex assembly	GO:0065003	256	0.414
dna integrity checkpoint	GO:0031570	81	0.412
establishment of vesicle localization	GO:0051650	51	0.394
regulation of receptor mediated endocytosis	GO:0048259	9	0.393
mitotic g2 dna damage checkpoint	GO:0007095	69	0.376
cytoskeleton dependent cytokinesis	GO:0061640	81	0.375
mitotic dna integrity checkpoint	GO:0044774	75	0.360
meiotic cell cycle	GO:0051321	171	0.359
spindle assembly	GO:0051225	80	0.355
cullin deneddylation	GO:0010388	3	0.327
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.313
gliogenesis	GO:0042063	80	0.303
cellular macromolecule localization	GO:0070727	220	0.291
regulation of mitotic cell cycle	GO:0007346	190	0.286
protein complex assembly	GO:0006461	200	0.281
ion transport	GO:0006811	145	0.266
regulation of cell cycle process	GO:0010564	181	0.261
regulation of cell cycle phase transition	GO:1901987	130	0.251
organic substance catabolic process	GO:1901575	308	0.241
intracellular transport	GO:0046907	228	0.241
microtubule cytoskeleton organization involved in mitosis	GO:1902850	52	0.235
mitotic spindle organization	GO:0007052	220	0.231
death	GO:0016265	284	0.227
mitotic cell cycle phase transition	GO:0044772	138	0.226
spindle organization	GO:0007051	253	0.222
dendrite development	GO:0016358	204	0.219
axon development	GO:0061564	297	0.214
cellular protein complex assembly	GO:0043623	71	0.211
multicellular organismal aging	GO:0010259	140	0.201
g2 dna damage checkpoint	GO:0031572	69	0.201
mitotic g2 m transition checkpoint	GO:0044818	70	0.200
axonogenesis	GO:0007409	290	0.197
mitochondrion organization	GO:0007005	65	0.197
maintenance of location	GO:0051235	73	0.192
regulation of cellular component biogenesis	GO:0044087	201	0.192
regulation of cellular localization	GO:0060341	136	0.189
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.187
axon guidance	GO:0007411	233	0.179
morphogenesis of embryonic epithelium	GO:0016331	94	0.176
regulation of localization	GO:0032879	275	0.176
synaptic vesicle transport	GO:0048489	50	0.175
mitotic dna damage checkpoint	GO:0044773	74	0.175
intracellular protein transport	GO:0006886	104	0.172
vesicle localization	GO:0051648	55	0.167
regulation of meiosis	GO:0040020	3	0.166
maintenance of protein location in cell	GO:0032507	26	0.163
protein localization to organelle	GO:0033365	82	0.160
cell cycle phase transition	GO:0044770	140	0.151
synaptic vesicle localization	GO:0097479	53	0.148
establishment of synaptic vesicle localization	GO:0097480	50	0.146
protein polymerization	GO:0051258	42	0.146
programmed cell death	GO:0012501	257	0.144
cell death	GO:0008219	279	0.143
multicellular organismal reproductive behavior	GO:0033057	110	0.141
cytoplasmic transport	GO:0016482	130	0.137
lipid localization	GO:0010876	54	0.136
regulation of transmembrane transport	GO:0034762	27	0.133
asymmetric neuroblast division	GO:0055059	33	0.131
aging	GO:0007568	143	0.130
maintenance of protein location	GO:0045185	28	0.130
single organism catabolic process	GO:0044712	228	0.129
negative regulation of mitotic cell cycle	GO:0045930	109	0.122
mitotic spindle checkpoint	GO:0071174	11	0.119
determination of adult lifespan	GO:0008340	137	0.118
proteolysis	GO:0006508	192	0.116
glycosyl compound catabolic process	GO:1901658	112	0.116
growth	GO:0040007	359	0.115
protein modification process	GO:0036211	438	0.113
positive regulation of macromolecule metabolic process	GO:0010604	405	0.110
cellular catabolic process	GO:0044248	372	0.108
embryonic development via the syncytial blastoderm	GO:0001700	148	0.107
organic substance transport	GO:0071702	257	0.106
positive regulation of developmental process	GO:0051094	143	0.106
neuron recognition	GO:0008038	101	0.105
brain development	GO:0007420	120	0.100
neuroblast proliferation	GO:0007405	74	0.098
dna repair	GO:0006281	54	0.097
lateral inhibition	GO:0046331	206	0.096
maintenance of location in cell	GO:0051651	28	0.094
ribonucleoside catabolic process	GO:0042454	112	0.093
chemical homeostasis	GO:0048878	92	0.089
metal ion transport	GO:0030001	74	0.087
establishment of mitotic spindle localization	GO:0040001	17	0.085
membrane organization	GO:0061024	112	0.085
establishment of protein localization to organelle	GO:0072594	62	0.083
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.078
taxis	GO:0042330	304	0.078
posttranscriptional regulation of gene expression	GO:0010608	145	0.077
regulation of neurogenesis	GO:0050767	158	0.076
regulation of protein catabolic process	GO:0042176	55	0.076
protein phosphorylation	GO:0006468	169	0.074
larval development	GO:0002164	104	0.073
regulation of growth	GO:0040008	233	0.073
organelle localization	GO:0051640	148	0.071
reproductive system development	GO:0061458	74	0.071
signal transduction by phosphorylation	GO:0023014	107	0.071
negative regulation of phosphorus metabolic process	GO:0010563	45	0.070
endocytosis	GO:0006897	310	0.070
regulation of protein metabolic process	GO:0051246	256	0.068
imaginal disc growth	GO:0007446	37	0.068
actin filament based process	GO:0030029	220	0.066
regulation of cell division	GO:0051302	72	0.066
positive regulation of gene expression	GO:0010628	290	0.065
ubiquitin dependent protein catabolic process	GO:0006511	78	0.065
heterocycle catabolic process	GO:0046700	166	0.065
positive regulation of cell communication	GO:0010647	250	0.065
nucleoside catabolic process	GO:0009164	112	0.063
protein import	GO:0017038	55	0.062
vesicle mediated transport	GO:0016192	381	0.062
establishment of protein localization	GO:0045184	163	0.062
neuromuscular junction development	GO:0007528	149	0.061
purine nucleotide catabolic process	GO:0006195	109	0.058
response to bacterium	GO:0009617	198	0.058
carbohydrate derivative catabolic process	GO:1901136	118	0.055
regulation of catabolic process	GO:0009894	170	0.054
cytokinesis	GO:0000910	90	0.053
meiotic chromosome segregation	GO:0045132	59	0.051
neuron projection extension	GO:1990138	32	0.051
negative regulation of cell cycle	GO:0045786	116	0.048
regulation of synapse organization	GO:0050807	110	0.047
meiotic cytokinesis	GO:0033206	33	0.046
intracellular protein transmembrane transport	GO:0065002	4	0.045
response to light stimulus	GO:0009416	124	0.045
sex differentiation	GO:0007548	81	0.045
neuromuscular synaptic transmission	GO:0007274	67	0.044
protein import into nucleus	GO:0006606	51	0.043
meiotic nuclear division	GO:0007126	151	0.042
positive regulation of transport	GO:0051050	92	0.042
protein targeting	GO:0006605	64	0.041
dendrite morphogenesis	GO:0048813	199	0.041
regulation of neuron projection development	GO:0010975	69	0.041
glycosyl compound metabolic process	GO:1901657	127	0.041
developmental cell growth	GO:0048588	52	0.041
regulation of nuclear division	GO:0051783	58	0.041
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.040
nucleoside phosphate catabolic process	GO:1901292	110	0.040
male gamete generation	GO:0048232	201	0.039
positive regulation of lipid biosynthetic process	GO:0046889	3	0.039
regulation of protein modification process	GO:0031399	112	0.039
nucleobase containing compound transport	GO:0015931	56	0.038
protein localization to nucleus	GO:0034504	55	0.038
developmental growth	GO:0048589	280	0.037
protein deneddylation	GO:0000338	8	0.037
single organism nuclear import	GO:1902593	51	0.037
neural precursor cell proliferation	GO:0061351	75	0.037
protein transport	GO:0015031	155	0.037
mitochondrion distribution	GO:0048311	10	0.037
apoptotic process	GO:0006915	159	0.037
organic cyclic compound catabolic process	GO:1901361	168	0.036
aromatic compound catabolic process	GO:0019439	166	0.036
regulation of protein localization to plasma membrane	GO:1903076	7	0.035
regulation of neuron differentiation	GO:0045664	103	0.035
dorsal closure	GO:0007391	79	0.035
regulation of cellular response to stress	GO:0080135	89	0.035
regulation of protein complex assembly	GO:0043254	42	0.034
organophosphate catabolic process	GO:0046434	112	0.034
transmembrane transport	GO:0055085	139	0.034
synapse assembly	GO:0007416	143	0.034
regulation of synapse structure and activity	GO:0050803	128	0.034
single organism intracellular transport	GO:1902582	207	0.034
single organism membrane organization	GO:0044802	93	0.033
macromolecule catabolic process	GO:0009057	161	0.033
protein modification by small protein conjugation or removal	GO:0070647	106	0.033
nucleotide catabolic process	GO:0009166	109	0.033
spindle localization	GO:0051653	22	0.033
ribonucleoside metabolic process	GO:0009119	127	0.032
regulation of hemocyte proliferation	GO:0035206	37	0.032
regulation of developmental growth	GO:0048638	174	0.032
nucleobase containing compound catabolic process	GO:0034655	165	0.032
regulation of protein stability	GO:0031647	43	0.032
purine containing compound catabolic process	GO:0072523	112	0.032
nucleoside triphosphate catabolic process	GO:0009143	108	0.031
neuron projection guidance	GO:0097485	241	0.031
nitrogen compound transport	GO:0071705	85	0.031
regulation of cell death	GO:0010941	173	0.031
imaginal disc derived appendage development	GO:0048737	399	0.031
positive regulation of multicellular organismal process	GO:0051240	143	0.030
regulation of cytoplasmic transport	GO:1903649	47	0.030
spermatid differentiation	GO:0048515	114	0.029
positive regulation of nucleocytoplasmic transport	GO:0046824	24	0.029
regulation of multicellular organismal development	GO:2000026	414	0.029
epithelial cell differentiation	GO:0030855	322	0.029
negative regulation of phosphate metabolic process	GO:0045936	45	0.029
establishment of rna localization	GO:0051236	47	0.029
salivary gland development	GO:0007431	162	0.028
rna processing	GO:0006396	147	0.028
head development	GO:0060322	135	0.028
peptidyl threonine modification	GO:0018210	3	0.027
establishment of spindle localization	GO:0051293	22	0.027
regulation of synaptic plasticity	GO:0048167	14	0.027
posttranscriptional gene silencing	GO:0016441	46	0.027
catabolic process	GO:0009056	409	0.027
modification dependent protein catabolic process	GO:0019941	78	0.027
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.026
ribonucleoside monophosphate catabolic process	GO:0009158	39	0.026
purine nucleoside catabolic process	GO:0006152	112	0.025
positive regulation of intracellular transport	GO:0032388	42	0.025
regulation of cellular protein metabolic process	GO:0032268	243	0.025
phosphorylation	GO:0016310	294	0.025
autophagy	GO:0006914	108	0.024
lipid storage	GO:0019915	38	0.024
synaptic growth at neuromuscular junction	GO:0051124	119	0.024
mesenchymal cell development	GO:0014031	1	0.024
mapk cascade	GO:0000165	107	0.024
regulation of phosphorus metabolic process	GO:0051174	210	0.024
response to other organism	GO:0051707	293	0.024
regulation of transport	GO:0051049	181	0.024
regulation of notch signaling pathway	GO:0008593	100	0.023
translation	GO:0006412	69	0.023
plasma membrane organization	GO:0007009	26	0.023
nucleotide metabolic process	GO:0009117	161	0.023
rna transport	GO:0050658	46	0.023
oocyte differentiation	GO:0009994	145	0.023
nucleoside phosphate metabolic process	GO:0006753	162	0.023
fertilization	GO:0009566	26	0.023
purine containing compound metabolic process	GO:0072521	155	0.023
cellular protein modification process	GO:0006464	438	0.022
morphogenesis of an epithelium	GO:0002009	276	0.022
protein modification by small protein removal	GO:0070646	28	0.022
synapse organization	GO:0050808	196	0.022
gland morphogenesis	GO:0022612	145	0.021
salivary gland morphogenesis	GO:0007435	145	0.021
negative regulation of neuron death	GO:1901215	18	0.021
protein targeting to nucleus	GO:0044744	51	0.021
cell projection assembly	GO:0030031	94	0.021
cation transport	GO:0006812	110	0.021
cell motility	GO:0048870	251	0.021
compound eye photoreceptor cell differentiation	GO:0001751	140	0.020
spindle assembly involved in mitosis	GO:0090307	50	0.020
regulation of anatomical structure size	GO:0090066	163	0.020
nucleocytoplasmic transport	GO:0006913	72	0.020
carbohydrate derivative metabolic process	GO:1901135	217	0.020
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.019
central nervous system development	GO:0007417	201	0.019
regulation of molecular function	GO:0065009	217	0.019
positive regulation of signaling	GO:0023056	243	0.019
regulation of g protein coupled receptor protein signaling pathway	GO:0008277	23	0.019
actin cytoskeleton organization	GO:0030036	206	0.019
proteasomal protein catabolic process	GO:0010498	59	0.019
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.019
signal release	GO:0023061	49	0.019
cilium assembly	GO:0042384	38	0.019
forebrain development	GO:0030900	2	0.018
atp catabolic process	GO:0006200	38	0.018
establishment of nucleus localization	GO:0040023	26	0.018
organonitrogen compound catabolic process	GO:1901565	128	0.018
neurological system process	GO:0050877	358	0.018
regulation of intracellular transport	GO:0032386	64	0.018
developmental growth involved in morphogenesis	GO:0060560	65	0.018
purine ribonucleoside catabolic process	GO:0046130	112	0.018
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.017
negative regulation of intrinsic apoptotic signaling pathway	GO:2001243	1	0.017
regulation of mitosis	GO:0007088	56	0.017
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.017
rna localization	GO:0006403	115	0.017
cilium organization	GO:0044782	41	0.017
reproductive behavior	GO:0019098	122	0.017
terminal button organization	GO:0072553	19	0.017
exocytosis	GO:0006887	28	0.017
synaptic vesicle recycling	GO:0036465	28	0.017
regulation of cellular catabolic process	GO:0031329	157	0.017
cell recognition	GO:0008037	102	0.017
stress activated mapk cascade	GO:0051403	52	0.016
response to growth factor	GO:0070848	31	0.016
cell maturation	GO:0048469	144	0.016
organophosphate metabolic process	GO:0019637	195	0.016
organonitrogen compound metabolic process	GO:1901564	318	0.016
stress activated protein kinase signaling cascade	GO:0031098	55	0.016
negative regulation of catabolic process	GO:0009895	36	0.016
notch signaling pathway	GO:0007219	120	0.016
spermatogenesis	GO:0007283	200	0.016
purine ribonucleoside metabolic process	GO:0046128	127	0.016
positive regulation of endocytosis	GO:0045807	22	0.016
development of primary sexual characteristics	GO:0045137	50	0.016
positive regulation of cellular component organization	GO:0051130	156	0.016
tube development	GO:0035295	244	0.016
locomotory behavior	GO:0007626	176	0.015
cell proliferation	GO:0008283	299	0.015
chromosome segregation	GO:0007059	157	0.015
cellular component assembly involved in morphogenesis	GO:0010927	151	0.015
nuclear import	GO:0051170	51	0.015
nucleoside metabolic process	GO:0009116	127	0.015
negative regulation of protein metabolic process	GO:0051248	85	0.015
receptor mediated endocytosis	GO:0006898	21	0.015
developmental programmed cell death	GO:0010623	138	0.014
purine ribonucleotide catabolic process	GO:0009154	109	0.014
establishment of cell polarity	GO:0030010	40	0.014
purine nucleoside metabolic process	GO:0042278	127	0.014
nuclear transport	GO:0051169	72	0.014
positive regulation of cellular biosynthetic process	GO:0031328	316	0.014
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.014
regulation of microtubule based process	GO:0032886	49	0.014
microtubule anchoring	GO:0034453	11	0.014
regulation of cellular protein catabolic process	GO:1903362	44	0.014
ribonucleotide catabolic process	GO:0009261	109	0.014
cellular response to chemical stimulus	GO:0070887	199	0.013
positive regulation of neurogenesis	GO:0050769	41	0.013
response to starvation	GO:0042594	97	0.013
energy derivation by oxidation of organic compounds	GO:0015980	32	0.013
cellular nitrogen compound catabolic process	GO:0044270	165	0.013
lipid transport	GO:0006869	18	0.013
positive regulation of chromatin modification	GO:1903310	17	0.013
germarium derived egg chamber formation	GO:0007293	101	0.013
epithelial cell development	GO:0002064	274	0.013
regulation of phosphate metabolic process	GO:0019220	210	0.013
response to radiation	GO:0009314	155	0.013
regulation of pathway restricted smad protein phosphorylation	GO:0060393	1	0.013
organelle fusion	GO:0048284	46	0.012
positive regulation of response to stimulus	GO:0048584	323	0.012
ovarian follicle cell migration	GO:0007297	121	0.012
regulation of protein targeting	GO:1903533	29	0.012
regulation of protein localization	GO:0032880	76	0.012
protein catabolic process	GO:0030163	101	0.012
eye development	GO:0001654	323	0.012
mesenchymal cell differentiation	GO:0048762	1	0.012
body morphogenesis	GO:0010171	2	0.012
dna dependent dna replication maintenance of fidelity	GO:0045005	0	0.012
regulation of establishment of protein localization	GO:0070201	61	0.012
regulation of intracellular protein transport	GO:0033157	46	0.012
protein processing	GO:0016485	68	0.012
gonad development	GO:0008406	50	0.012
negative regulation of catalytic activity	GO:0043086	42	0.012
regulation of nucleocytoplasmic transport	GO:0046822	35	0.012
positive regulation of nervous system development	GO:0051962	69	0.012
genitalia development	GO:0048806	26	0.012
imaginal disc derived wing margin morphogenesis	GO:0008587	41	0.011
regulation of neuronal synaptic plasticity	GO:0048168	8	0.011
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.011
mitochondrial fission	GO:0000266	8	0.011
hair cell differentiation	GO:0035315	47	0.011
oxoacid metabolic process	GO:0043436	103	0.011
meiotic cell cycle process	GO:1903046	132	0.011
sister chromatid segregation	GO:0000819	92	0.011
response to extracellular stimulus	GO:0009991	116	0.011
negative regulation of cellular protein metabolic process	GO:0032269	85	0.011
response to biotic stimulus	GO:0009607	294	0.011
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.011
regulation of microtubule cytoskeleton organization	GO:0070507	41	0.011
eye photoreceptor cell differentiation	GO:0001754	145	0.011
trna modification	GO:0006400	2	0.011
nucleic acid transport	GO:0050657	46	0.010
r7 cell differentiation	GO:0045466	43	0.010
negative regulation of neurogenesis	GO:0050768	53	0.010
regulation of catalytic activity	GO:0050790	185	0.010
regulation of cell development	GO:0060284	215	0.010
embryonic morphogenesis	GO:0048598	206	0.010
regulation of mitotic sister chromatid segregation	GO:0033047	28	0.010
protein localization to plasma membrane	GO:0072659	13	0.010
regulation of mapk cascade	GO:0043408	92	0.010
mitotic sister chromatid segregation	GO:0000070	87	0.010

Pp2A-29B disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
nervous system disease	DOID:863	0.030
disease of anatomical entity	DOID:7	0.030
neurodegenerative disease	DOID:1289	0.014
central nervous system disease	DOID:331	0.014

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