IMP: Integrative Multi-species Prediction

Drosophila melanogaster

9 known processes

ClC-b (Dmel_CG8594)

Chloride channel-b

(Aliases: DmClCb,CG8594,DmClC-b,Dmel\CG8594)

FLYBASE: FBgn0033755
Entrez: 36381
UniProtKB: Q7JZ25

Process Predictions
Disease Predictions

ClC-b biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
sensory perception of touch	GO:0050975	11	0.853
single organism behavior	GO:0044708	391	0.627
ion transmembrane transport	GO:0034220	122	0.272
regulation of ion transport	GO:0043269	39	0.267
sensory perception of mechanical stimulus	GO:0050954	72	0.210
sensory perception	GO:0007600	196	0.196
growth	GO:0040007	359	0.140
learning or memory	GO:0007611	141	0.125
endocytosis	GO:0006897	310	0.118
organic substance transport	GO:0071702	257	0.113
regulation of growth	GO:0040008	233	0.092
cognition	GO:0050890	141	0.088
response to other organism	GO:0051707	293	0.088
locomotory behavior	GO:0007626	176	0.076
intracellular signal transduction	GO:0035556	300	0.075
phagocytosis	GO:0006909	215	0.071
vesicle mediated transport	GO:0016192	381	0.071
single organism membrane fusion	GO:0044801	42	0.070
positive regulation of signal transduction	GO:0009967	223	0.066
response to bacterium	GO:0009617	198	0.065
death	GO:0016265	284	0.065
positive regulation of response to stimulus	GO:0048584	323	0.064
neurological system process	GO:0050877	358	0.064
regulation of transport	GO:0051049	181	0.063
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.060
response to biotic stimulus	GO:0009607	294	0.060
cation transmembrane transport	GO:0098655	88	0.060
response to monosaccharide	GO:0034284	4	0.060
synaptic transmission	GO:0007268	288	0.059
metal ion homeostasis	GO:0055065	44	0.058
transmembrane transport	GO:0055085	139	0.055
ras protein signal transduction	GO:0007265	88	0.052
chemical homeostasis	GO:0048878	92	0.050
glycosyl compound metabolic process	GO:1901657	127	0.049
response to external biotic stimulus	GO:0043207	293	0.048
organic substance catabolic process	GO:1901575	308	0.047
response to pheromone	GO:0019236	19	0.047
regionalization	GO:0003002	416	0.044
regulation of localization	GO:0032879	275	0.043
programmed cell death	GO:0012501	257	0.043
digestive tract morphogenesis	GO:0048546	127	0.043
cation transport	GO:0006812	110	0.042
nucleoside phosphate metabolic process	GO:0006753	162	0.040
nitrogen compound transport	GO:0071705	85	0.040
apoptotic process	GO:0006915	159	0.039
organophosphate metabolic process	GO:0019637	195	0.039
purine ribonucleoside metabolic process	GO:0046128	127	0.039
cell death	GO:0008219	279	0.039
male courtship behavior	GO:0008049	63	0.038
regulation of anatomical structure size	GO:0090066	163	0.038
regulation of metal ion transport	GO:0010959	15	0.036
heterocycle catabolic process	GO:0046700	166	0.036
embryonic morphogenesis	GO:0048598	206	0.036
neuromuscular synaptic transmission	GO:0007274	67	0.035
regulation of synapse structure and activity	GO:0050803	128	0.034
determination of adult lifespan	GO:0008340	137	0.034
nucleotide metabolic process	GO:0009117	161	0.034
multi multicellular organism process	GO:0044706	123	0.034
regulation of nervous system development	GO:0051960	248	0.033
positive regulation of signaling	GO:0023056	243	0.033
small molecule metabolic process	GO:0044281	305	0.033
cation homeostasis	GO:0055080	51	0.033
cell migration	GO:0016477	238	0.033
regulation of anatomical structure morphogenesis	GO:0022603	242	0.033
defense response to other organism	GO:0098542	225	0.033
nucleoside metabolic process	GO:0009116	127	0.031
cellular response to chemical stimulus	GO:0070887	199	0.031
multicellular organismal reproductive behavior	GO:0033057	110	0.031
negative regulation of cellular metabolic process	GO:0031324	382	0.031
multi organism behavior	GO:0051705	175	0.029
gastrulation	GO:0007369	70	0.029
ion transport	GO:0006811	145	0.029
regulation of protein localization	GO:0032880	76	0.029
response to wounding	GO:0009611	94	0.028
regulation of cell death	GO:0010941	173	0.027
mechanosensory behavior	GO:0007638	12	0.027
defense response to bacterium	GO:0042742	178	0.027
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.027
defense response	GO:0006952	300	0.027
single organism carbohydrate metabolic process	GO:0044723	72	0.027
response to glucose	GO:0009749	2	0.027
anion transport	GO:0006820	41	0.026
detection of stimulus	GO:0051606	156	0.026
macromolecular complex assembly	GO:0065003	256	0.026
protein localization	GO:0008104	284	0.026
nucleobase containing small molecule metabolic process	GO:0055086	174	0.025
developmental growth	GO:0048589	280	0.025
negative regulation of cellular component organization	GO:0051129	108	0.025
organic acid metabolic process	GO:0006082	103	0.025
negative regulation of response to stimulus	GO:0048585	258	0.025
regulation of intracellular signal transduction	GO:1902531	236	0.025
regulation of developmental growth	GO:0048638	174	0.025
carbohydrate derivative metabolic process	GO:1901135	217	0.025
body morphogenesis	GO:0010171	2	0.023
g2 dna damage checkpoint	GO:0031572	69	0.022
regulation of behavior	GO:0050795	75	0.022
tube morphogenesis	GO:0035239	191	0.022
purine nucleoside metabolic process	GO:0042278	127	0.022
cellular protein complex assembly	GO:0043623	71	0.022
vacuole organization	GO:0007033	8	0.022
response to hexose	GO:0009746	3	0.022
small gtpase mediated signal transduction	GO:0007264	88	0.021
metal ion transport	GO:0030001	74	0.021
ribonucleoside catabolic process	GO:0042454	112	0.021
positive regulation of transport	GO:0051050	92	0.021
actin filament based movement	GO:0030048	26	0.021
regulation of phosphorus metabolic process	GO:0051174	210	0.021
calcium ion transport	GO:0006816	24	0.021
embryo development ending in birth or egg hatching	GO:0009792	152	0.021
multicellular organismal aging	GO:0010259	140	0.021
cellular nitrogen compound catabolic process	GO:0044270	165	0.020
single organism catabolic process	GO:0044712	228	0.020
negative regulation of cell death	GO:0060548	81	0.020
regulation of apoptotic process	GO:0042981	130	0.020
learning	GO:0007612	75	0.019
aging	GO:0007568	143	0.019
protein transport	GO:0015031	155	0.019
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.019
positive regulation of cell communication	GO:0010647	250	0.019
regulation of hemocyte proliferation	GO:0035206	37	0.019
sensory perception of pain	GO:0019233	4	0.019
carboxylic acid transport	GO:0046942	18	0.019
amino acid transport	GO:0006865	12	0.019
divalent inorganic cation transport	GO:0072511	30	0.019
ribonucleotide metabolic process	GO:0009259	145	0.019
nucleoside triphosphate metabolic process	GO:0009141	120	0.019
ion homeostasis	GO:0050801	55	0.019
nucleoside catabolic process	GO:0009164	112	0.018
response to osmotic stress	GO:0006970	14	0.018
wound healing	GO:0042060	75	0.018
cell type specific apoptotic process	GO:0097285	38	0.018
organonitrogen compound metabolic process	GO:1901564	318	0.017
forebrain development	GO:0030900	2	0.017
monovalent inorganic cation transport	GO:0015672	40	0.017
ribonucleoside metabolic process	GO:0009119	127	0.017
meiotic nuclear division	GO:0007126	151	0.017
neuron recognition	GO:0008038	101	0.017
sensory perception of chemical stimulus	GO:0007606	116	0.017
larval locomotory behavior	GO:0008345	27	0.017
response to organic substance	GO:0010033	284	0.017
regulation of cell differentiation	GO:0045595	302	0.017
ovarian follicle cell development	GO:0030707	248	0.016
carboxylic acid metabolic process	GO:0019752	92	0.016
aggressive behavior	GO:0002118	63	0.016
secretion	GO:0046903	109	0.016
nucleoside phosphate catabolic process	GO:1901292	110	0.016
purine containing compound catabolic process	GO:0072523	112	0.016
positive regulation of rna metabolic process	GO:0051254	271	0.016
regulation of ras protein signal transduction	GO:0046578	93	0.015
columnar cuboidal epithelial cell development	GO:0002066	249	0.015
cellular catabolic process	GO:0044248	372	0.015
regulation of cellular component biogenesis	GO:0044087	201	0.015
detection of mechanical stimulus involved in sensory perception of pain	GO:0050966	2	0.015
translation	GO:0006412	69	0.015
response to acid chemical	GO:0001101	25	0.015
phosphorylation	GO:0016310	294	0.015
regulation of neuron death	GO:1901214	26	0.015
protein complex biogenesis	GO:0070271	201	0.015
membrane organization	GO:0061024	112	0.015
rna transport	GO:0050658	46	0.015
epiboly	GO:0090504	2	0.015
carbohydrate derivative catabolic process	GO:1901136	118	0.015
homeostatic process	GO:0042592	199	0.015
positive regulation of cellular biosynthetic process	GO:0031328	316	0.015
central nervous system development	GO:0007417	201	0.015
positive regulation of transcription dna templated	GO:0045893	266	0.015
ribonucleotide catabolic process	GO:0009261	109	0.015
monocarboxylic acid transport	GO:0015718	3	0.015
behavioral response to pain	GO:0048266	3	0.014
nucleotide catabolic process	GO:0009166	109	0.014
purine nucleoside monophosphate catabolic process	GO:0009128	38	0.014
epiboly involved in wound healing	GO:0090505	2	0.014
localization of cell	GO:0051674	257	0.014
establishment of localization in cell	GO:0051649	402	0.014
organelle fission	GO:0048285	340	0.014
divalent metal ion transport	GO:0070838	26	0.014
regulation of organelle organization	GO:0033043	196	0.014
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.014
organelle fusion	GO:0048284	46	0.014
associative learning	GO:0008306	65	0.014
catabolic process	GO:0009056	409	0.014
mapk cascade	GO:0000165	107	0.013
purine ribonucleoside catabolic process	GO:0046130	112	0.013
purine containing compound metabolic process	GO:0072521	155	0.013
organic acid transport	GO:0015849	18	0.013
organic anion transport	GO:0015711	28	0.013
gtp catabolic process	GO:0006184	72	0.013
protein polymerization	GO:0051258	42	0.013
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.013
connective tissue development	GO:0061448	3	0.013
regulation of vesicle mediated transport	GO:0060627	59	0.013
pharynx development	GO:0060465	1	0.013
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.013
regulation of cell morphogenesis	GO:0022604	163	0.013
negative regulation of cell communication	GO:0010648	223	0.013
drinking behavior	GO:0042756	2	0.013
chemotaxis	GO:0006935	249	0.013
immune system process	GO:0002376	347	0.012
biological adhesion	GO:0022610	138	0.012
response to oxygen containing compound	GO:1901700	200	0.012
camera type eye morphogenesis	GO:0048593	2	0.012
protein modification process	GO:0036211	438	0.012
limb development	GO:0060173	1	0.012
organophosphate catabolic process	GO:0046434	112	0.012
larval development	GO:0002164	104	0.012
hindbrain development	GO:0030902	2	0.012
anion transmembrane transport	GO:0098656	26	0.012
regulation of programmed cell death	GO:0043067	152	0.012
establishment of protein localization	GO:0045184	163	0.012
glycosyl compound catabolic process	GO:1901658	112	0.012
membrane fusion	GO:0061025	42	0.012
lipid modification	GO:0030258	24	0.012
positive regulation of phosphate metabolic process	GO:0045937	139	0.012
negative regulation of biosynthetic process	GO:0009890	277	0.012
response to decreased oxygen levels	GO:0036293	58	0.012
organic cyclic compound catabolic process	GO:1901361	168	0.012
nucleobase containing compound catabolic process	GO:0034655	165	0.012
digestive system development	GO:0055123	149	0.012
g protein coupled receptor signaling pathway	GO:0007186	136	0.011
organonitrogen compound catabolic process	GO:1901565	128	0.011
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.011
retina development in camera type eye	GO:0060041	4	0.011
cellular component assembly involved in morphogenesis	GO:0010927	151	0.011
positive regulation of multicellular organismal process	GO:0051240	143	0.011
regulation of mapk cascade	GO:0043408	92	0.011
rrna processing	GO:0006364	3	0.011
regulation of endocytosis	GO:0030100	37	0.011
actin filament organization	GO:0007015	126	0.011
regulation of system process	GO:0044057	36	0.011
epithelial cell differentiation	GO:0030855	322	0.011
actin cytoskeleton organization	GO:0030036	206	0.011
positive regulation of intracellular signal transduction	GO:1902533	116	0.011
neuron death	GO:0070997	27	0.011
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.011
protein complex assembly	GO:0006461	200	0.011
mating	GO:0007618	120	0.011
carbohydrate derivative biosynthetic process	GO:1901137	85	0.010
response to salt stress	GO:0009651	11	0.010
adult locomotory behavior	GO:0008344	76	0.010
organelle assembly	GO:0070925	198	0.010
cell motility	GO:0048870	251	0.010
positive regulation of biosynthetic process	GO:0009891	316	0.010
negative regulation of nervous system development	GO:0051961	92	0.010
ribose phosphate metabolic process	GO:0019693	145	0.010
cellular response to dna damage stimulus	GO:0006974	223	0.010
negative regulation of signaling	GO:0023057	219	0.010

ClC-b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of anatomical entity	DOID:7	0.145	Human
lower respiratory tract disease	DOID:0050161	0.033
bronchial disease	DOID:1176	0.033
respiratory system disease	DOID:1579	0.033
nervous system disease	DOID:863	0.025
central nervous system disease	DOID:331	0.014
disease of metabolism	DOID:0014667	0.011

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