IMP: Integrative Multi-species Prediction

Drosophila melanogaster

67 known processes

Max (Dmel_CG9648)

CG9648 gene product from transcript CG9648-RA

(Aliases: bHLHd9,MAX,Dmel\CG9648,CG9648,max,dmax,dMax)

Entrez: 40095
FLYBASE: FBgn0017578
UniProtKB: M9NDC9
UniProtKB: P91664

Process Predictions
Disease Predictions

Max biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.797
negative regulation of rna metabolic process	GO:0051253	251	0.573
negative regulation of cellular metabolic process	GO:0031324	382	0.526
negative regulation of transcription dna templated	GO:0045892	237	0.425
cellular catabolic process	GO:0044248	372	0.397
cell proliferation	GO:0008283	299	0.384
negative regulation of rna biosynthetic process	GO:1902679	240	0.380
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.293
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.280
intracellular transport	GO:0046907	228	0.276
positive regulation of rna metabolic process	GO:0051254	271	0.245
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.227
carboxylic acid metabolic process	GO:0019752	92	0.207
positive regulation of transcription dna templated	GO:0045893	266	0.206
negative regulation of gene expression	GO:0010629	387	0.204
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.200
macromolecular complex assembly	GO:0065003	256	0.196	Zebrafish Rat
regulation of cell cycle	GO:0051726	291	0.194
organic acid metabolic process	GO:0006082	103	0.191
growth	GO:0040007	359	0.182
regulation of cell cycle phase transition	GO:1901987	130	0.177
single organism intracellular transport	GO:1902582	207	0.162
transcription from rna polymerase ii promoter	GO:0006366	368	0.158
regulation of growth	GO:0040008	233	0.156
death	GO:0016265	284	0.152	Rat
mitotic dna damage checkpoint	GO:0044773	74	0.149
regulation of developmental growth	GO:0048638	174	0.148
g2 dna damage checkpoint	GO:0031572	69	0.146
cellular response to dna damage stimulus	GO:0006974	223	0.144
oxoacid metabolic process	GO:0043436	103	0.140
programmed cell death	GO:0012501	257	0.139	Rat
mitotic cell cycle checkpoint	GO:0007093	88	0.137
establishment of localization in cell	GO:0051649	402	0.135
negative regulation of cell cycle phase transition	GO:1901988	103	0.129
negative regulation of cellular biosynthetic process	GO:0031327	277	0.127
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.124
response to organic substance	GO:0010033	284	0.123	Rat
negative regulation of cell development	GO:0010721	62	0.123
asymmetric neuroblast division	GO:0055059	33	0.122
negative regulation of cell cycle process	GO:0010948	109	0.121
regulation of epithelial cell proliferation	GO:0050678	4	0.121
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.121
regionalization	GO:0003002	416	0.120	Zebrafish
positive regulation of growth	GO:0045927	75	0.117
positive regulation of gene expression	GO:0010628	290	0.115
regulation of cell cycle process	GO:0010564	181	0.114
regulation of programmed cell death	GO:0043067	152	0.110
epithelial cell differentiation	GO:0030855	322	0.106
tissue morphogenesis	GO:0048729	297	0.103
protein modification process	GO:0036211	438	0.099
eye development	GO:0001654	323	0.096	Rat
cell death	GO:0008219	279	0.095	Rat
mitotic g2 dna damage checkpoint	GO:0007095	69	0.095
cell cycle phase transition	GO:0044770	140	0.094
morphogenesis of an epithelium	GO:0002009	276	0.093
positive regulation of developmental growth	GO:0048639	62	0.093
response to endogenous stimulus	GO:0009719	119	0.092	Rat
positive regulation of biosynthetic process	GO:0009891	316	0.088
multi multicellular organism process	GO:0044706	123	0.086
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.085
negative regulation of biosynthetic process	GO:0009890	277	0.084
mitotic cell cycle phase transition	GO:0044772	138	0.082
positive regulation of cellular biosynthetic process	GO:0031328	316	0.079
male gamete generation	GO:0048232	201	0.079
small molecule metabolic process	GO:0044281	305	0.078
rna processing	GO:0006396	147	0.077
protein ubiquitination	GO:0016567	70	0.076
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.075
eye morphogenesis	GO:0048592	260	0.075
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.073
positive regulation of rna biosynthetic process	GO:1902680	266	0.073
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.072
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.072
negative regulation of nervous system development	GO:0051961	92	0.071
sulfur compound metabolic process	GO:0006790	59	0.070
spermatogenesis	GO:0007283	200	0.066
wnt signaling pathway	GO:0016055	98	0.065
catabolic process	GO:0009056	409	0.064
negative regulation of multicellular organismal process	GO:0051241	142	0.062
circadian behavior	GO:0048512	76	0.062
positive regulation of signaling	GO:0023056	243	0.061
negative regulation of mitotic cell cycle	GO:0045930	109	0.058
regulation of protein metabolic process	GO:0051246	256	0.058
positive regulation of wnt signaling pathway	GO:0030177	25	0.057
aging	GO:0007568	143	0.057
organonitrogen compound metabolic process	GO:1901564	318	0.057
cellular macromolecular complex assembly	GO:0034622	153	0.057
negative regulation of programmed cell death	GO:0043069	72	0.056
cellular amino acid metabolic process	GO:0006520	61	0.055
positive regulation of protein deacetylation	GO:0090312	2	0.054
nuclear division	GO:0000280	332	0.054
nuclear export	GO:0051168	24	0.053
organelle fission	GO:0048285	340	0.053
compound eye development	GO:0048749	307	0.052
endocytosis	GO:0006897	310	0.051
response to abiotic stimulus	GO:0009628	341	0.051
cell migration	GO:0016477	238	0.050
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.050
mitotic g2 m transition checkpoint	GO:0044818	70	0.049
positive regulation of signal transduction	GO:0009967	223	0.049
positive regulation of cell communication	GO:0010647	250	0.049
negative regulation of epithelial cell proliferation	GO:0050680	4	0.048
neuromuscular junction development	GO:0007528	149	0.047
cellular lipid metabolic process	GO:0044255	83	0.047
positive regulation of macromolecule metabolic process	GO:0010604	405	0.047
taxis	GO:0042330	304	0.047
positive regulation of programmed cell death	GO:0043068	62	0.047
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.046
regulation of cell proliferation	GO:0042127	163	0.046
dna integrity checkpoint	GO:0031570	81	0.046
cell cycle checkpoint	GO:0000075	95	0.046
cell division	GO:0051301	248	0.045
negative regulation of cell cycle	GO:0045786	116	0.044
body morphogenesis	GO:0010171	2	0.044
macromolecule catabolic process	GO:0009057	161	0.043
columnar cuboidal epithelial cell development	GO:0002066	249	0.043
gland development	GO:0048732	191	0.042
stem cell differentiation	GO:0048863	117	0.042
positive regulation of response to stimulus	GO:0048584	323	0.041
head development	GO:0060322	135	0.041
regulation of mitotic cell cycle	GO:0007346	190	0.040
neurological system process	GO:0050877	358	0.039
dna replication	GO:0006260	48	0.039
response to extracellular stimulus	GO:0009991	116	0.039	Rat
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.038
single organism biosynthetic process	GO:0044711	206	0.038
regulation of phosphate metabolic process	GO:0019220	210	0.038
organic substance transport	GO:0071702	257	0.037
regulation of nervous system development	GO:0051960	248	0.037
negative regulation of response to stimulus	GO:0048585	258	0.037
neuronal stem cell division	GO:0036445	35	0.037
dna damage checkpoint	GO:0000077	78	0.036
regulation of wnt signaling pathway	GO:0030111	68	0.036
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.035
positive regulation of histone deacetylation	GO:0031065	2	0.035
central nervous system development	GO:0007417	201	0.035
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.035
somatic stem cell division	GO:0048103	37	0.035
muscle organ development	GO:0007517	127	0.035
mitotic dna integrity checkpoint	GO:0044774	75	0.035
negative regulation of wnt signaling pathway	GO:0030178	28	0.035
lipid metabolic process	GO:0006629	121	0.035
regulation of neurogenesis	GO:0050767	158	0.034
positive regulation of cell death	GO:0010942	69	0.034
multi organism reproductive behavior	GO:0044705	121	0.034
wing disc pattern formation	GO:0035222	66	0.034
regulation of cellular ketone metabolic process	GO:0010565	3	0.034
organic substance catabolic process	GO:1901575	308	0.033
regulation of synapse organization	GO:0050807	110	0.033
larval development	GO:0002164	104	0.033
secretion by cell	GO:0032940	101	0.033
purine ribonucleoside biosynthetic process	GO:0046129	3	0.032
sensory organ morphogenesis	GO:0090596	260	0.032
imaginal disc pattern formation	GO:0007447	91	0.032
neuroblast proliferation	GO:0007405	74	0.032
muscle structure development	GO:0061061	224	0.031
developmental programmed cell death	GO:0010623	138	0.031
negative regulation of cell proliferation	GO:0008285	69	0.031
response to ethanol	GO:0045471	59	0.031
single organism catabolic process	GO:0044712	228	0.031
cell motility	GO:0048870	251	0.031
negative regulation of cell differentiation	GO:0045596	143	0.030
multi organism behavior	GO:0051705	175	0.030
vesicle mediated transport	GO:0016192	381	0.030
ras protein signal transduction	GO:0007265	88	0.029
ameboidal type cell migration	GO:0001667	151	0.029
epithelial cell migration	GO:0010631	148	0.029
ribonucleoside biosynthetic process	GO:0042455	3	0.028
regulation of histone deacetylation	GO:0031063	2	0.028
regulation of localization	GO:0032879	275	0.028
cell cycle arrest	GO:0007050	4	0.028
cortical cytoskeleton organization	GO:0030865	29	0.028
cellular ketone metabolic process	GO:0042180	24	0.028
negative regulation of developmental process	GO:0051093	201	0.027
cellular protein modification process	GO:0006464	438	0.027
adult behavior	GO:0030534	137	0.027
regulation of cell death	GO:0010941	173	0.027
negative regulation of neurogenesis	GO:0050768	53	0.027
dorsal ventral pattern formation	GO:0009953	133	0.027	Zebrafish
cellular nitrogen compound catabolic process	GO:0044270	165	0.026
reproductive behavior	GO:0019098	122	0.026
regulation of multicellular organism growth	GO:0040014	40	0.026
response to starvation	GO:0042594	97	0.026	Rat
cellular response to chemical stimulus	GO:0070887	199	0.026	Rat
stem cell proliferation	GO:0072089	88	0.025
response to organic cyclic compound	GO:0014070	89	0.025
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.025
stem cell development	GO:0048864	79	0.025
cytoplasmic transport	GO:0016482	130	0.025
stem cell division	GO:0017145	69	0.024
organic hydroxy compound metabolic process	GO:1901615	83	0.024
metarhodopsin inactivation	GO:0016060	5	0.024
post embryonic appendage morphogenesis	GO:0035120	385	0.024
glycosyl compound metabolic process	GO:1901657	127	0.023
camera type eye development	GO:0043010	4	0.023	Rat
mesenchymal cell differentiation	GO:0048762	1	0.023
skeletal muscle tissue development	GO:0007519	13	0.023
hematopoietic progenitor cell differentiation	GO:0002244	1	0.023
homeostatic process	GO:0042592	199	0.023
gland morphogenesis	GO:0022612	145	0.023
secretion	GO:0046903	109	0.022
mesenchymal cell development	GO:0014031	1	0.022
salivary gland development	GO:0007431	162	0.022
regulation of cellular amine metabolic process	GO:0033238	3	0.022
signal transduction in response to dna damage	GO:0042770	3	0.022
transforming growth factor beta receptor signaling pathway	GO:0007179	16	0.022
response to radiation	GO:0009314	155	0.022
lateral inhibition	GO:0046331	206	0.022
regulation of response to stress	GO:0080134	200	0.021
regulation of cellular protein metabolic process	GO:0032268	243	0.021
appendage development	GO:0048736	401	0.021
positive regulation of multicellular organismal process	GO:0051240	143	0.021
regulation of cellular component biogenesis	GO:0044087	201	0.021
regulation of phosphorus metabolic process	GO:0051174	210	0.021
nitrogen compound transport	GO:0071705	85	0.020
chaeta development	GO:0022416	97	0.020
intracellular signal transduction	GO:0035556	300	0.020
response to carbon dioxide	GO:0010037	4	0.020
regulation of multicellular organismal development	GO:2000026	414	0.020
exocrine system development	GO:0035272	162	0.020
positive regulation of mitotic cell cycle phase transition	GO:1901992	20	0.020
regulation of cellular amino acid metabolic process	GO:0006521	0	0.020
synaptic growth at neuromuscular junction	GO:0051124	119	0.020
regulation of apoptotic process	GO:0042981	130	0.019
peptidyl threonine phosphorylation	GO:0018107	2	0.019
neural precursor cell proliferation	GO:0061351	75	0.019
dna metabolic process	GO:0006259	227	0.019
positive regulation of multicellular organism growth	GO:0040018	21	0.019
regulation of peptidyl lysine acetylation	GO:2000756	7	0.019
cortical actin cytoskeleton organization	GO:0030866	24	0.019
regulation of nuclear division	GO:0051783	58	0.019
epithelial cell proliferation	GO:0050673	15	0.019
negative regulation of cellular component organization	GO:0051129	108	0.019
apoptotic process	GO:0006915	159	0.019	Rat
organic cyclic compound catabolic process	GO:1901361	168	0.018
positive regulation of cellular amine metabolic process	GO:0033240	0	0.018
gliogenesis	GO:0042063	80	0.017
epithelial cell development	GO:0002064	274	0.017
regulation of protein ubiquitination	GO:0031396	22	0.017
actin filament based process	GO:0030029	220	0.017
neuron projection guidance	GO:0097485	241	0.017
regulation of hydrolase activity	GO:0051336	97	0.017
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.017
developmental growth	GO:0048589	280	0.017
response to alcohol	GO:0097305	95	0.017
response to oxygen containing compound	GO:1901700	200	0.016	Rat
single organism behavior	GO:0044708	391	0.016
leg disc development	GO:0035218	92	0.016
localization of cell	GO:0051674	257	0.016
appendage morphogenesis	GO:0035107	397	0.016
establishment of imaginal disc derived wing hair orientation	GO:0001737	24	0.016
intracellular protein transport	GO:0006886	104	0.016
notch signaling pathway	GO:0007219	120	0.016
regulation of catalytic activity	GO:0050790	185	0.016
positive regulation of transport	GO:0051050	92	0.016
gene silencing	GO:0016458	138	0.015
mushroom body development	GO:0016319	70	0.015
leg disc morphogenesis	GO:0007478	80	0.015
aromatic compound catabolic process	GO:0019439	166	0.015
imaginal disc derived leg morphogenesis	GO:0007480	80	0.015
carbohydrate derivative catabolic process	GO:1901136	118	0.015
negative regulation of synaptic growth at neuromuscular junction	GO:0045886	39	0.015
heterocycle catabolic process	GO:0046700	166	0.015
dorsal ventral pattern formation imaginal disc	GO:0007450	51	0.015
neuroblast division	GO:0055057	35	0.015
actin cytoskeleton organization	GO:0030036	206	0.015
wing disc dorsal ventral pattern formation	GO:0048190	47	0.015
regulation of immune system process	GO:0002682	176	0.015
eye photoreceptor cell fate commitment	GO:0042706	37	0.015
ribonucleotide catabolic process	GO:0009261	109	0.015
peptidyl amino acid modification	GO:0018193	105	0.014
mitotic nuclear division	GO:0007067	213	0.014
transmission of nerve impulse	GO:0019226	12	0.014
nucleocytoplasmic transport	GO:0006913	72	0.014
extracellular structure organization	GO:0043062	46	0.014
single organism cellular localization	GO:1902580	180	0.014
cellular protein localization	GO:0034613	160	0.014
regulation of protein modification process	GO:0031399	112	0.014
regulation of phosphorylation	GO:0042325	147	0.014
protein transport	GO:0015031	155	0.014
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	4	0.014
amine metabolic process	GO:0009308	12	0.014
cellular response to radiation	GO:0071478	52	0.014
brain development	GO:0007420	120	0.013
morphogenesis of embryonic epithelium	GO:0016331	94	0.013
regulation of cell development	GO:0060284	215	0.013
axon guidance	GO:0007411	233	0.013
response to nitrogen compound	GO:1901698	90	0.013	Rat
negative regulation of protein metabolic process	GO:0051248	85	0.013
negative regulation of compound eye retinal cell programmed cell death	GO:0046673	7	0.013
response to insulin	GO:0032868	29	0.013	Rat
multicellular organismal signaling	GO:0035637	12	0.013
response to decreased oxygen levels	GO:0036293	58	0.013
protein modification by small protein conjugation or removal	GO:0070647	106	0.013
cellular response to organic substance	GO:0071310	132	0.013	Rat
ensheathment of neurons	GO:0007272	10	0.013
heart contraction	GO:0060047	26	0.013
epithelium migration	GO:0090132	148	0.013
ion transport	GO:0006811	145	0.012
regulation of protein deacetylation	GO:0090311	2	0.012
cellular response to nutrient levels	GO:0031669	62	0.012	Rat
heart process	GO:0003015	37	0.012
enteroendocrine cell differentiation	GO:0035883	1	0.012
cell aging	GO:0007569	2	0.012
organonitrogen compound catabolic process	GO:1901565	128	0.012
cellular response to carbon dioxide	GO:0071244	2	0.012
respiratory system development	GO:0060541	213	0.012
chemotaxis	GO:0006935	249	0.012
purine nucleoside catabolic process	GO:0006152	112	0.012
regulation of protein acetylation	GO:1901983	7	0.012
histone acetylation	GO:0016573	38	0.012
ovarian follicle cell development	GO:0030707	248	0.012
positive regulation of developmental process	GO:0051094	143	0.012
forebrain development	GO:0030900	2	0.012
cellular response to oxygen levels	GO:0071453	30	0.012
ribonucleoprotein complex biogenesis	GO:0022613	31	0.011
connective tissue development	GO:0061448	3	0.011
negative regulation of cellular protein metabolic process	GO:0032269	85	0.011
associative learning	GO:0008306	65	0.011
learning	GO:0007612	75	0.011
response to temperature stimulus	GO:0009266	106	0.011
purine nucleotide metabolic process	GO:0006163	146	0.011
negative regulation of cell death	GO:0060548	81	0.011
small gtpase mediated signal transduction	GO:0007264	88	0.011
regulation of anatomical structure morphogenesis	GO:0022603	242	0.011
protein complex biogenesis	GO:0070271	201	0.011	Zebrafish Rat
rrna processing	GO:0006364	3	0.011
renal tubule morphogenesis	GO:0061333	44	0.011
regulation of cellular catabolic process	GO:0031329	157	0.011
cellular amine metabolic process	GO:0044106	12	0.010
regulation of purine nucleotide biosynthetic process	GO:1900371	14	0.010
response to nutrient levels	GO:0031667	114	0.010	Rat
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	4	0.010
sperm individualization	GO:0007291	48	0.010
regulation of reproductive process	GO:2000241	54	0.010
camera type eye morphogenesis	GO:0048593	2	0.010
positive regulation of cellular protein metabolic process	GO:0032270	118	0.010
negative regulation of neuroblast proliferation	GO:0007406	27	0.010
nucleobase containing compound transport	GO:0015931	56	0.010
blood circulation	GO:0008015	26	0.010

Max disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
central nervous system disease	DOID:331	0.011
disease of anatomical entity	DOID:7	0.011
nervous system disease	DOID:863	0.011

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network