IMP: Integrative Multi-species Prediction

Drosophila melanogaster

23 known processes

hk (Dmel_CG10653)

hook

(Aliases: CG10653,Dmel\CG10653,dHk)

Entrez: 35169
FLYBASE: FBgn0001202
UniProtKB: Q24185

Process Predictions
Disease Predictions

hk biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
locomotory behavior	GO:0007626	176	0.837
membrane fusion	GO:0061025	42	0.819
response to starvation	GO:0042594	97	0.805
single organism behavior	GO:0044708	391	0.781
establishment of localization in cell	GO:0051649	402	0.748
endosome to lysosome transport	GO:0008333	7	0.681
single organism membrane fusion	GO:0044801	42	0.529
synaptic vesicle endocytosis	GO:0048488	28	0.470
single organism intracellular transport	GO:1902582	207	0.444
organelle fusion	GO:0048284	46	0.365
cellular response to extracellular stimulus	GO:0031668	64	0.361
regulation of cell differentiation	GO:0045595	302	0.314
entrainment of circadian clock	GO:0009649	16	0.313
cellular response to starvation	GO:0009267	61	0.283
determination of adult lifespan	GO:0008340	137	0.256
synaptic vesicle recycling	GO:0036465	28	0.241
regulation of nervous system development	GO:0051960	248	0.223
organelle membrane fusion	GO:0090174	16	0.214
synaptic transmission	GO:0007268	288	0.200
purine ribonucleotide metabolic process	GO:0009150	145	0.195
positive regulation of rna biosynthetic process	GO:1902680	266	0.194
purine containing compound metabolic process	GO:0072521	155	0.190
macroautophagy	GO:0016236	42	0.188
autophagic vacuole fusion	GO:0000046	15	0.186
synaptic vesicle localization	GO:0097479	53	0.186
adult behavior	GO:0030534	137	0.184
cell death	GO:0008219	279	0.172
establishment of synaptic vesicle localization	GO:0097480	50	0.168
aging	GO:0007568	143	0.164
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.151
multi organism reproductive behavior	GO:0044705	121	0.151
ribonucleotide metabolic process	GO:0009259	145	0.141
regulation of autophagy	GO:0010506	62	0.128
adult locomotory behavior	GO:0008344	76	0.127
endocytosis	GO:0006897	310	0.127
regulation of cell cycle process	GO:0010564	181	0.123
gliogenesis	GO:0042063	80	0.119
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.113
lysosomal transport	GO:0007041	13	0.112
cellular response to nutrient levels	GO:0031669	62	0.102
regulation of catabolic process	GO:0009894	170	0.101
cell proliferation	GO:0008283	299	0.097
neuroblast proliferation	GO:0007405	74	0.097
organelle localization	GO:0051640	148	0.096
multicellular organismal aging	GO:0010259	140	0.095
regulation of growth	GO:0040008	233	0.094
establishment of protein localization to organelle	GO:0072594	62	0.092
regulation of mitotic cell cycle	GO:0007346	190	0.089
positive regulation of response to stimulus	GO:0048584	323	0.084
regulation of catalytic activity	GO:0050790	185	0.081
regulation of cell death	GO:0010941	173	0.078
regulation of protein transport	GO:0051223	57	0.078
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.077
cytoplasmic transport	GO:0016482	130	0.076
regulation of phosphorus metabolic process	GO:0051174	210	0.075
endosomal transport	GO:0016197	44	0.074
secretion	GO:0046903	109	0.073
negative regulation of developmental process	GO:0051093	201	0.072
regulation of molecular function	GO:0065009	217	0.071
death	GO:0016265	284	0.071
developmental programmed cell death	GO:0010623	138	0.070
positive regulation of hydrolase activity	GO:0051345	78	0.069
regulation of cell development	GO:0060284	215	0.068
programmed cell death	GO:0012501	257	0.066
cellular catabolic process	GO:0044248	372	0.065
negative regulation of developmental growth	GO:0048640	64	0.064
notch receptor processing	GO:0007220	13	0.064
organophosphate metabolic process	GO:0019637	195	0.062
organelle assembly	GO:0070925	198	0.059
regulation of phosphate metabolic process	GO:0019220	210	0.058
positive regulation of multicellular organismal process	GO:0051240	143	0.057
regulation of cellular catabolic process	GO:0031329	157	0.057
positive regulation of rna metabolic process	GO:0051254	271	0.057
regulation of transport	GO:0051049	181	0.056
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.055
regulation of organelle organization	GO:0033043	196	0.054
regulation of vesicle mediated transport	GO:0060627	59	0.054
secretion by cell	GO:0032940	101	0.054
developmental growth	GO:0048589	280	0.053
negative regulation of molecular function	GO:0044092	51	0.053
compound eye development	GO:0048749	307	0.052
anatomical structure homeostasis	GO:0060249	97	0.052
nucleobase containing small molecule metabolic process	GO:0055086	174	0.051
mitotic cell cycle phase transition	GO:0044772	138	0.051
organonitrogen compound metabolic process	GO:1901564	318	0.051
regulation of hydrolase activity	GO:0051336	97	0.050
signal release	GO:0023061	49	0.048
protein targeting	GO:0006605	64	0.048
intracellular transport	GO:0046907	228	0.046
response to extracellular stimulus	GO:0009991	116	0.046
regulation of developmental growth	GO:0048638	174	0.045
dorsal ventral pattern formation	GO:0009953	133	0.045
homeostatic process	GO:0042592	199	0.044
mitotic dna damage checkpoint	GO:0044773	74	0.044
regulation of localization	GO:0032879	275	0.044
notch signaling pathway	GO:0007219	120	0.043
purine nucleotide metabolic process	GO:0006163	146	0.043
regulation of response to stress	GO:0080134	200	0.043
phenol containing compound metabolic process	GO:0018958	57	0.043
vesicle mediated transport	GO:0016192	381	0.042
immune system development	GO:0002520	57	0.042
regulation of programmed cell death	GO:0043067	152	0.041
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.041
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.041
regulation of multicellular organismal development	GO:2000026	414	0.040
negative regulation of response to stimulus	GO:0048585	258	0.040
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.039
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.038
glycosyl compound metabolic process	GO:1901657	127	0.037
negative regulation of cell communication	GO:0010648	223	0.034
regulation of cell cycle	GO:0051726	291	0.034
central nervous system development	GO:0007417	201	0.033
eye development	GO:0001654	323	0.033
purine containing compound biosynthetic process	GO:0072522	30	0.033
nucleotide metabolic process	GO:0009117	161	0.033
negative regulation of programmed cell death	GO:0043069	72	0.033
positive regulation of developmental process	GO:0051094	143	0.033
regulation of cellular response to stress	GO:0080135	89	0.033
small molecule metabolic process	GO:0044281	305	0.032
regulation of anatomical structure size	GO:0090066	163	0.032
forebrain development	GO:0030900	2	0.032
stem cell proliferation	GO:0072089	88	0.032
learning or memory	GO:0007611	141	0.032
eye pigment granule organization	GO:0008057	12	0.032
positive regulation of cell development	GO:0010720	61	0.031
cell cycle checkpoint	GO:0000075	95	0.031
response to nutrient levels	GO:0031667	114	0.031
dopamine biosynthetic process	GO:0042416	3	0.031
negative regulation of cell differentiation	GO:0045596	143	0.031
cellular response to external stimulus	GO:0071496	66	0.029
regulation of cellular component biogenesis	GO:0044087	201	0.029
establishment of vesicle localization	GO:0051650	51	0.029
negative regulation of nervous system development	GO:0051961	92	0.029
positive regulation of catabolic process	GO:0009896	105	0.029
early endosome to late endosome transport	GO:0045022	3	0.028
telencephalon development	GO:0021537	2	0.028
protein localization	GO:0008104	284	0.028
negative regulation of multicellular organismal process	GO:0051241	142	0.028
oocyte maturation	GO:0001556	3	0.028
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.028
response to decreased oxygen levels	GO:0036293	58	0.027
gtp catabolic process	GO:0006184	72	0.027
single organism catabolic process	GO:0044712	228	0.027
pigment granule organization	GO:0048753	12	0.027
response to organonitrogen compound	GO:0010243	75	0.026
catabolic process	GO:0009056	409	0.026
cellular homeostasis	GO:0019725	80	0.025
regulation of purine nucleotide catabolic process	GO:0033121	48	0.024
mitotic dna integrity checkpoint	GO:0044774	75	0.024
response to ethanol	GO:0045471	59	0.024
negative regulation of signal transduction	GO:0009968	206	0.023
brain development	GO:0007420	120	0.023
establishment of organelle localization	GO:0051656	122	0.023
purine nucleoside catabolic process	GO:0006152	112	0.021
positive regulation of transcription dna templated	GO:0045893	266	0.021
response to oxygen containing compound	GO:1901700	200	0.021
dna double strand break processing	GO:0000729	3	0.021
regulation of cell cycle phase transition	GO:1901987	130	0.021
regulation of steroid metabolic process	GO:0019218	2	0.021
dna damage checkpoint	GO:0000077	78	0.021
positive regulation of molecular function	GO:0044093	136	0.021
response to anesthetic	GO:0072347	9	0.021
centrosome cycle	GO:0007098	137	0.020
regulation of nurse cell apoptotic process	GO:0045477	9	0.020
neurological system process	GO:0050877	358	0.020
response to reactive oxygen species	GO:0000302	24	0.020
carbohydrate derivative metabolic process	GO:1901135	217	0.019
positive regulation of intracellular protein transport	GO:0090316	30	0.019
cellular response to dna damage stimulus	GO:0006974	223	0.019
purine nucleotide catabolic process	GO:0006195	109	0.019
regulation of response to external stimulus	GO:0032101	115	0.019
guanosine containing compound catabolic process	GO:1901069	74	0.019
regulation of nucleotide metabolic process	GO:0006140	62	0.019
cell cycle phase transition	GO:0044770	140	0.019
negative regulation of neuron apoptotic process	GO:0043524	14	0.019
axonogenesis	GO:0007409	290	0.019
protein targeting to nucleus	GO:0044744	51	0.019
response to temperature stimulus	GO:0009266	106	0.018
exocytosis	GO:0006887	28	0.018
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.018
tube development	GO:0035295	244	0.017
appendage segmentation	GO:0035285	26	0.017
taxis	GO:0042330	304	0.017
positive regulation of gene expression	GO:0010628	290	0.017
regulation of notch signaling pathway	GO:0008593	100	0.017
protein phosphorylation	GO:0006468	169	0.017
membrane organization	GO:0061024	112	0.017
negative regulation of cell death	GO:0060548	81	0.017
neuromuscular process	GO:0050905	21	0.017
phosphorylation	GO:0016310	294	0.017
purine ribonucleoside metabolic process	GO:0046128	127	0.017
regulation of cell cycle g1 s phase transition	GO:1902806	23	0.016
regulation of wnt signaling pathway	GO:0030111	68	0.016
regulation of neuron apoptotic process	GO:0043523	16	0.016
regulation of epithelial cell proliferation	GO:0050678	4	0.016
regulation of cell proliferation	GO:0042127	163	0.015
positive regulation of apoptotic process	GO:0043065	47	0.015
catecholamine metabolic process	GO:0006584	10	0.015
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.015
regulation of cellular localization	GO:0060341	136	0.015
positive regulation of biosynthetic process	GO:0009891	316	0.015
nucleoside phosphate metabolic process	GO:0006753	162	0.015
positive regulation of signal transduction	GO:0009967	223	0.015
regulation of apoptotic process	GO:0042981	130	0.015
purine nucleoside metabolic process	GO:0042278	127	0.015
head development	GO:0060322	135	0.015
cellular metal ion homeostasis	GO:0006875	31	0.015
regulation of intracellular protein transport	GO:0033157	46	0.014
neural precursor cell proliferation	GO:0061351	75	0.014
negative regulation of apoptotic process	GO:0043066	63	0.014
endomembrane system organization	GO:0010256	119	0.014
regulation of nucleoside metabolic process	GO:0009118	50	0.014
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.014
organic substance transport	GO:0071702	257	0.014
regulation of purine nucleotide metabolic process	GO:1900542	62	0.014
positive regulation of macromolecule metabolic process	GO:0010604	405	0.014
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.014
regulation of protein targeting	GO:1903533	29	0.014
regulation of protein metabolic process	GO:0051246	256	0.014
axon guidance	GO:0007411	233	0.014
negative regulation of signaling	GO:0023057	219	0.013
organonitrogen compound catabolic process	GO:1901565	128	0.013
nucleoside triphosphate catabolic process	GO:0009143	108	0.013
regulation of necrotic cell death	GO:0010939	1	0.013
nucleoside catabolic process	GO:0009164	112	0.013
compound eye morphogenesis	GO:0001745	249	0.013
purine ribonucleoside catabolic process	GO:0046130	112	0.013
intracellular protein transport	GO:0006886	104	0.013
negative regulation of biosynthetic process	GO:0009890	277	0.013
regulation of intracellular signal transduction	GO:1902531	236	0.013
leg disc morphogenesis	GO:0007478	80	0.013
entrainment of circadian clock by photoperiod	GO:0043153	9	0.013
positive regulation of cell death	GO:0010942	69	0.012
positive regulation of protein transport	GO:0051222	37	0.012
regulation of synapse assembly	GO:0051963	94	0.012
regulation of nucleotide catabolic process	GO:0030811	48	0.012
protein catabolic process	GO:0030163	101	0.012
purine containing compound catabolic process	GO:0072523	112	0.012
positive regulation of cellular catabolic process	GO:0031331	95	0.012
regulation of circadian rhythm	GO:0042752	49	0.012
positive regulation of neuron apoptotic process	GO:0043525	1	0.012
positive regulation of phosphorus metabolic process	GO:0010562	139	0.012
growth	GO:0040007	359	0.012
regulation of g1 s transition of mitotic cell cycle	GO:2000045	23	0.012
larval development	GO:0002164	104	0.012
negative regulation of rna metabolic process	GO:0051253	251	0.012
ribonucleoside catabolic process	GO:0042454	112	0.011
lysosome organization	GO:0007040	4	0.011
organonitrogen compound biosynthetic process	GO:1901566	117	0.011
regulation of synaptic vesicle transport	GO:1902803	10	0.011
cell maturation	GO:0048469	144	0.011
organic hydroxy compound metabolic process	GO:1901615	83	0.011
regulation of cytoskeleton organization	GO:0051493	89	0.011
cell cycle arrest	GO:0007050	4	0.011
vesicle localization	GO:0051648	55	0.011
response to calcium ion	GO:0051592	1	0.011
negative regulation of mitotic cell cycle	GO:0045930	109	0.011
cellular pigmentation	GO:0033059	12	0.011
negative regulation of cell proliferation	GO:0008285	69	0.011
camera type eye morphogenesis	GO:0048593	2	0.011
imaginal disc pattern formation	GO:0007447	91	0.011
neuron maturation	GO:0042551	31	0.011
cell growth	GO:0016049	108	0.010
flight behavior	GO:0007629	26	0.010
positive regulation of cell communication	GO:0010647	250	0.010
wnt signaling pathway	GO:0016055	98	0.010
regulation of synaptic transmission	GO:0050804	69	0.010
purine ribonucleoside monophosphate biosynthetic process	GO:0009168	3	0.010

hk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
cancer	DOID:162	0.028
organ system cancer	DOID:0050686	0.028
disease of cellular proliferation	DOID:14566	0.028
disease of anatomical entity	DOID:7	0.027
nervous system disease	DOID:863	0.017
central nervous system disease	DOID:331	0.017
neurodegenerative disease	DOID:1289	0.017
synucleinopathy	DOID:0050890	0.013

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