IMP: Integrative Multi-species Prediction

Drosophila melanogaster

14 known processes

CG11876 (Dmel_CG11876)

CG11876 gene product from transcript CG11876-RA

(Aliases: Dmel\CG11876,PDHB,E1beta)

FLYBASE: FBgn0039635
Entrez: 43437
UniProtKB: Q7K5K3
UniProtKB: Q8IML6

Process Predictions
Disease Predictions

CG11876 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
nucleotide metabolic process	GO:0009117	161	0.632
nucleobase containing small molecule metabolic process	GO:0055086	174	0.607
single organism biosynthetic process	GO:0044711	206	0.527	Human Yeast Rat
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.524
mitochondrion organization	GO:0007005	65	0.515
small molecule metabolic process	GO:0044281	305	0.505	Human Yeast Rat
organophosphate metabolic process	GO:0019637	195	0.459
atp metabolic process	GO:0046034	49	0.427
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.403
organonitrogen compound metabolic process	GO:1901564	318	0.399
ribose phosphate metabolic process	GO:0019693	145	0.370
nucleoside triphosphate metabolic process	GO:0009141	120	0.352
carbohydrate derivative metabolic process	GO:1901135	217	0.346
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.318
glycosyl compound metabolic process	GO:1901657	127	0.302
nucleoside phosphate metabolic process	GO:0006753	162	0.294
ribonucleotide metabolic process	GO:0009259	145	0.292
purine nucleoside metabolic process	GO:0042278	127	0.283
ribonucleoside metabolic process	GO:0009119	127	0.273
ribose phosphate biosynthetic process	GO:0046390	28	0.254
nucleoside monophosphate metabolic process	GO:0009123	52	0.251
purine nucleotide metabolic process	GO:0006163	146	0.206
purine containing compound biosynthetic process	GO:0072522	30	0.186
membrane organization	GO:0061024	112	0.180
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.173
purine containing compound metabolic process	GO:0072521	155	0.172
cellular respiration	GO:0045333	26	0.156	Human
purine ribonucleoside metabolic process	GO:0046128	127	0.153
monocarboxylic acid metabolic process	GO:0032787	29	0.150	Human Yeast Rat
nicotinamide nucleotide metabolic process	GO:0046496	2	0.149
purine ribonucleotide biosynthetic process	GO:0009152	28	0.147
organonitrogen compound biosynthetic process	GO:1901566	117	0.140
nucleoside metabolic process	GO:0009116	127	0.130
establishment of localization in cell	GO:0051649	402	0.120
organophosphate biosynthetic process	GO:0090407	46	0.116
ribonucleoside triphosphate biosynthetic process	GO:0009201	2	0.114
purine ribonucleotide metabolic process	GO:0009150	145	0.103
atp biosynthetic process	GO:0006754	2	0.101
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.092
organic acid metabolic process	GO:0006082	103	0.092	Human Yeast Rat
carbohydrate derivative biosynthetic process	GO:1901137	85	0.091
catabolic process	GO:0009056	409	0.086
exocrine system development	GO:0035272	162	0.086
transmembrane transport	GO:0055085	139	0.085
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.084
negative regulation of biosynthetic process	GO:0009890	277	0.083
ribonucleoside biosynthetic process	GO:0042455	3	0.080
single organism membrane organization	GO:0044802	93	0.077
response to abiotic stimulus	GO:0009628	341	0.073
gland development	GO:0048732	191	0.073
generation of precursor metabolites and energy	GO:0006091	42	0.072	Human
regulation of protein metabolic process	GO:0051246	256	0.070
purine ribonucleoside monophosphate biosynthetic process	GO:0009168	3	0.069
cell death	GO:0008219	279	0.067
purine nucleotide biosynthetic process	GO:0006164	29	0.065
oxidation reduction process	GO:0055114	123	0.063	Human Yeast Rat
oxoacid metabolic process	GO:0043436	103	0.060	Human Yeast Rat
pyridine nucleotide metabolic process	GO:0019362	2	0.060
aging	GO:0007568	143	0.059
carboxylic acid metabolic process	GO:0019752	92	0.056	Human Yeast Rat
nucleoside phosphate biosynthetic process	GO:1901293	34	0.054
intracellular transport	GO:0046907	228	0.054
embryo development ending in birth or egg hatching	GO:0009792	152	0.052
regulation of cellular protein metabolic process	GO:0032268	243	0.052
protein complex assembly	GO:0006461	200	0.051
response to organic substance	GO:0010033	284	0.048
energy derivation by oxidation of organic compounds	GO:0015980	32	0.048	Human
tube morphogenesis	GO:0035239	191	0.048
central nervous system development	GO:0007417	201	0.047
regulation of organelle organization	GO:0033043	196	0.047
pyridine containing compound metabolic process	GO:0072524	3	0.046
ion transport	GO:0006811	145	0.045
ion transmembrane transport	GO:0034220	122	0.044
oxidoreduction coenzyme metabolic process	GO:0006733	2	0.044
cell division	GO:0051301	248	0.044
glycosyl compound biosynthetic process	GO:1901659	3	0.044
nucleotide biosynthetic process	GO:0009165	34	0.044
purine nucleoside monophosphate biosynthetic process	GO:0009127	3	0.043
regulation of molecular function	GO:0065009	217	0.043
thioester metabolic process	GO:0035383	3	0.042	Human Yeast Rat
acyl coa biosynthetic process	GO:0071616	2	0.042	Human Yeast Rat
developmental programmed cell death	GO:0010623	138	0.042
purine ribonucleoside biosynthetic process	GO:0046129	3	0.042
ribonucleoside monophosphate biosynthetic process	GO:0009156	3	0.041
protein complex biogenesis	GO:0070271	201	0.040
negative regulation of cellular metabolic process	GO:0031324	382	0.040
ribonucleotide biosynthetic process	GO:0009260	28	0.040
negative regulation of gene expression	GO:0010629	387	0.039
cellular catabolic process	GO:0044248	372	0.038
death	GO:0016265	284	0.038
determination of adult lifespan	GO:0008340	137	0.037
organic substance catabolic process	GO:1901575	308	0.037
larval development	GO:0002164	104	0.037
negative regulation of developmental process	GO:0051093	201	0.036
salivary gland development	GO:0007431	162	0.035
vesicle mediated transport	GO:0016192	381	0.035
negative regulation of cellular biosynthetic process	GO:0031327	277	0.034
gland morphogenesis	GO:0022612	145	0.033
tricarboxylic acid metabolic process	GO:0072350	1	0.033
cation transport	GO:0006812	110	0.032
intracellular signal transduction	GO:0035556	300	0.032
histolysis	GO:0007559	102	0.032
immune response	GO:0006955	246	0.031
single organism catabolic process	GO:0044712	228	0.031
reactive oxygen species metabolic process	GO:0072593	22	0.030
regulation of cell cycle phase transition	GO:1901987	130	0.030
pyruvate metabolic process	GO:0006090	7	0.030	Human Yeast Rat
growth	GO:0040007	359	0.029
regulation of catalytic activity	GO:0050790	185	0.029
regulation of catabolic process	GO:0009894	170	0.029
salivary gland morphogenesis	GO:0007435	145	0.029
phosphorylation	GO:0016310	294	0.028
negative regulation of cellular protein metabolic process	GO:0032269	85	0.028
positive regulation of molecular function	GO:0044093	136	0.027
cellular response to organic substance	GO:0071310	132	0.027
multicellular organismal aging	GO:0010259	140	0.025
electron transport chain	GO:0022900	14	0.025
macromolecular complex assembly	GO:0065003	256	0.024
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.024
programmed cell death	GO:0012501	257	0.024
negative regulation of cellular component organization	GO:0051129	108	0.024
atp synthesis coupled electron transport	GO:0042773	8	0.023
detection of light stimulus	GO:0009583	58	0.023
cellular component assembly involved in morphogenesis	GO:0010927	151	0.023
nucleoside triphosphate biosynthetic process	GO:0009142	2	0.022
spermatogenesis	GO:0007283	200	0.022
cell growth	GO:0016049	108	0.021
single organism membrane fusion	GO:0044801	42	0.021
single organism behavior	GO:0044708	391	0.020
negative regulation of multicellular organismal process	GO:0051241	142	0.020
brain development	GO:0007420	120	0.020
positive regulation of signaling	GO:0023056	243	0.019
head development	GO:0060322	135	0.019
proteolysis	GO:0006508	192	0.018
inorganic cation transmembrane transport	GO:0098662	61	0.018
respiratory electron transport chain	GO:0022904	11	0.017
lipid biosynthetic process	GO:0008610	46	0.017
cation transmembrane transport	GO:0098655	88	0.017
organic substance transport	GO:0071702	257	0.017
positive regulation of macromolecule metabolic process	GO:0010604	405	0.017
oxidative phosphorylation	GO:0006119	9	0.017
nucleoside monophosphate biosynthetic process	GO:0009124	4	0.017
negative regulation of protein metabolic process	GO:0051248	85	0.017
chromosome organization	GO:0051276	360	0.016
regulation of cell death	GO:0010941	173	0.016
cellular macromolecular complex assembly	GO:0034622	153	0.016
regulation of proteolysis	GO:0030162	87	0.016
acyl coa metabolic process	GO:0006637	3	0.016	Human Yeast Rat
actin cytoskeleton organization	GO:0030036	206	0.016
organic cyclic compound catabolic process	GO:1901361	168	0.015
purine nucleoside triphosphate biosynthetic process	GO:0009145	2	0.015
regulation of multicellular organismal development	GO:2000026	414	0.015
lipid metabolic process	GO:0006629	121	0.015
phagocytosis	GO:0006909	215	0.015
secretion by cell	GO:0032940	101	0.015
single organism cellular localization	GO:1902580	180	0.015
response to organic cyclic compound	GO:0014070	89	0.015
chromosome separation	GO:0051304	42	0.015
regionalization	GO:0003002	416	0.015
regulation of cellular catabolic process	GO:0031329	157	0.015
mitotic spindle organization	GO:0007052	220	0.015
chromatin organization	GO:0006325	207	0.015
monovalent inorganic cation transport	GO:0015672	40	0.015
endocytosis	GO:0006897	310	0.014
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.014
regulation of cell differentiation	GO:0045595	302	0.014
eggshell chorion assembly	GO:0007306	66	0.014
regulation of cellular amine metabolic process	GO:0033238	3	0.014
regulation of mitotic metaphase anaphase transition	GO:0030071	26	0.014
response to extracellular stimulus	GO:0009991	116	0.014
protein transport	GO:0015031	155	0.014
negative regulation of growth	GO:0045926	84	0.014
regulation of phosphorus metabolic process	GO:0051174	210	0.014
actin filament based process	GO:0030029	220	0.014
cell proliferation	GO:0008283	299	0.014
citrate metabolic process	GO:0006101	0	0.013
single organism intracellular transport	GO:1902582	207	0.013
mitochondrial fusion	GO:0008053	7	0.013
small molecule biosynthetic process	GO:0044283	37	0.013
establishment or maintenance of bipolar cell polarity	GO:0061245	34	0.013
cytoplasmic microtubule organization	GO:0031122	22	0.013
negative regulation of cell proliferation	GO:0008285	69	0.013
regulation of intracellular signal transduction	GO:1902531	236	0.013
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.013
sensory perception	GO:0007600	196	0.013
positive regulation of protein metabolic process	GO:0051247	128	0.013
synaptic transmission	GO:0007268	288	0.013
response to radiation	GO:0009314	155	0.012
response to organophosphorus	GO:0046683	2	0.012
cellular protein complex assembly	GO:0043623	71	0.012
regulation of metaphase anaphase transition of cell cycle	GO:1902099	26	0.012
purine containing compound catabolic process	GO:0072523	112	0.012
male gamete generation	GO:0048232	201	0.012
negative regulation of signaling	GO:0023057	219	0.012
urogenital system development	GO:0001655	72	0.012
epithelial tube morphogenesis	GO:0060562	88	0.012
mitotic nuclear division	GO:0007067	213	0.011
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.011
purine ribonucleoside triphosphate biosynthetic process	GO:0009206	2	0.011
regulation of growth	GO:0040008	233	0.011
regulation of membrane potential	GO:0042391	35	0.011
positive regulation of cell communication	GO:0010647	250	0.011
ribonucleotide catabolic process	GO:0009261	109	0.011
nucleoside biosynthetic process	GO:0009163	3	0.011
regulation of apoptotic process	GO:0042981	130	0.011
organophosphate catabolic process	GO:0046434	112	0.011
kidney development	GO:0001822	3	0.011
organonitrogen compound catabolic process	GO:1901565	128	0.011
protein processing	GO:0016485	68	0.011
response to nutrient levels	GO:0031667	114	0.011
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.011
neuroblast proliferation	GO:0007405	74	0.011
response to hypoxia	GO:0001666	53	0.011
regulation of programmed cell death	GO:0043067	152	0.011
renal system development	GO:0072001	72	0.011
mitochondrial atp synthesis coupled electron transport	GO:0042775	8	0.010
positive regulation of response to stimulus	GO:0048584	323	0.010
chaeta development	GO:0022416	97	0.010
regulation of phosphate metabolic process	GO:0019220	210	0.010
negative regulation of response to stimulus	GO:0048585	258	0.010
response to oxygen containing compound	GO:1901700	200	0.010
cellular nitrogen compound catabolic process	GO:0044270	165	0.010
cellular ketone metabolic process	GO:0042180	24	0.010
positive regulation of viral process	GO:0048524	2	0.010

CG11876 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.059
disease of cellular proliferation	DOID:14566	0.038
cancer	DOID:162	0.034
organ system cancer	DOID:0050686	0.034
disease of metabolism	DOID:0014667	0.029
nervous system disease	DOID:863	0.026
inherited metabolic disorder	DOID:655	0.018
eye and adnexa disease	DOID:1492	0.010
eye disease	DOID:5614	0.010
sensory system disease	DOID:0050155	0.010

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