IMP: Integrative Multi-species Prediction

Drosophila melanogaster

0 known processes

Sirt7 (Dmel_CG11305)

CG11305 gene product from transcript CG11305-RA

(Aliases: Dmel\CG11305,CG11305,dSIRT7,D.mel5,dmSRT409)

Entrez: 43433
FLYBASE: FBgn0039631
UniProtKB: Q9VAQ1

Process Predictions
Disease Predictions

Sirt7 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
neurological system process	GO:0050877	358	0.210
positive regulation of macromolecule metabolic process	GO:0010604	405	0.171	Human
memory	GO:0007613	94	0.162
sensory perception	GO:0007600	196	0.149
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.123
mitotic cell cycle checkpoint	GO:0007093	88	0.121
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.105
positive regulation of rna biosynthetic process	GO:1902680	266	0.102	Human
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.095	Human Fly
appendage morphogenesis	GO:0035107	397	0.090
positive regulation of transcription dna templated	GO:0045893	266	0.088	Human
negative regulation of cellular biosynthetic process	GO:0031327	277	0.087	Human Fly
cellular protein modification process	GO:0006464	438	0.087	Human
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.083	Human
negative regulation of rna metabolic process	GO:0051253	251	0.077	Human Fly
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.077
regulation of cell cycle	GO:0051726	291	0.076
phosphorylation	GO:0016310	294	0.076
response to organic substance	GO:0010033	284	0.075
regulation of multicellular organismal development	GO:2000026	414	0.074
positive regulation of gene expression	GO:0010628	290	0.073	Human
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.073	Human
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.069	Human
negative regulation of cellular metabolic process	GO:0031324	382	0.068	Human Fly
protein modification process	GO:0036211	438	0.067	Human
developmental growth	GO:0048589	280	0.067
mitotic cell cycle phase transition	GO:0044772	138	0.066
cellular macromolecule localization	GO:0070727	220	0.066
regulation of phosphate metabolic process	GO:0019220	210	0.066
regulation of phosphorus metabolic process	GO:0051174	210	0.062
nuclear division	GO:0000280	332	0.062	Human
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.061	Human Fly
mitotic g2 dna damage checkpoint	GO:0007095	69	0.060
imaginal disc pattern formation	GO:0007447	91	0.057
actin cytoskeleton organization	GO:0030036	206	0.053
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.052	Human
imaginal disc derived appendage development	GO:0048737	399	0.052
catabolic process	GO:0009056	409	0.049
embryonic development via the syncytial blastoderm	GO:0001700	148	0.049
post embryonic appendage morphogenesis	GO:0035120	385	0.048
negative regulation of gene expression	GO:0010629	387	0.046	Human Fly
imaginal disc derived wing morphogenesis	GO:0007476	337	0.046
histone modification	GO:0016570	106	0.045	Human
response to abiotic stimulus	GO:0009628	341	0.044
mitotic g2 m transition checkpoint	GO:0044818	70	0.043
adult behavior	GO:0030534	137	0.042
cellular response to dna damage stimulus	GO:0006974	223	0.042
tube morphogenesis	GO:0035239	191	0.039
cell cycle phase transition	GO:0044770	140	0.039
appendage development	GO:0048736	401	0.039
embryonic morphogenesis	GO:0048598	206	0.038
chromatin modification	GO:0016568	147	0.038	Human
proteolysis	GO:0006508	192	0.037
developmental programmed cell death	GO:0010623	138	0.036
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.035	Human Fly
organonitrogen compound metabolic process	GO:1901564	318	0.035
wing disc morphogenesis	GO:0007472	344	0.035
response to oxygen containing compound	GO:1901700	200	0.035
open tracheal system development	GO:0007424	204	0.035
regionalization	GO:0003002	416	0.034
positive regulation of cellular biosynthetic process	GO:0031328	316	0.033	Human
cell death	GO:0008219	279	0.033
regulation of nervous system development	GO:0051960	248	0.032
negative regulation of cell cycle phase transition	GO:1901988	103	0.031
tube development	GO:0035295	244	0.031
positive regulation of catabolic process	GO:0009896	105	0.030
transcription from rna polymerase ii promoter	GO:0006366	368	0.030	Human
regulation of cell cycle phase transition	GO:1901987	130	0.029
growth	GO:0040007	359	0.028
negative regulation of biosynthetic process	GO:0009890	277	0.028	Human Fly
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.028	Human
response to alcohol	GO:0097305	95	0.027
covalent chromatin modification	GO:0016569	106	0.027	Human
cellular protein localization	GO:0034613	160	0.027
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.027
negative regulation of rna biosynthetic process	GO:1902679	240	0.026	Human Fly
eye morphogenesis	GO:0048592	260	0.026
regulation of mapk cascade	GO:0043408	92	0.025
regulation of cellular amino acid metabolic process	GO:0006521	0	0.025
regulation of molecular function	GO:0065009	217	0.025
chromatin organization	GO:0006325	207	0.025	Human
organelle fission	GO:0048285	340	0.025	Human
regulation of phosphorylation	GO:0042325	147	0.024
spindle organization	GO:0007051	253	0.024
positive regulation of phosphorylation	GO:0042327	87	0.023
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.023
chromosome organization	GO:0051276	360	0.023	Human
protein modification by small protein conjugation or removal	GO:0070647	106	0.023
organic substance catabolic process	GO:1901575	308	0.023
tissue death	GO:0016271	102	0.023
regulation of mitotic cell cycle	GO:0007346	190	0.023
response to radiation	GO:0009314	155	0.022
regulation of cellular protein metabolic process	GO:0032268	243	0.022
telencephalon development	GO:0021537	2	0.022
maintenance of protein location in cell	GO:0032507	26	0.022
mitotic dna damage checkpoint	GO:0044773	74	0.022
learning or memory	GO:0007611	141	0.021
regulation of cell cycle process	GO:0010564	181	0.021
cellular macromolecule catabolic process	GO:0044265	136	0.021
regulation of cellular ketone metabolic process	GO:0010565	3	0.021
camera type eye development	GO:0043010	4	0.021
organic cyclic compound catabolic process	GO:1901361	168	0.020
regulation of intracellular signal transduction	GO:1902531	236	0.020
gene silencing	GO:0016458	138	0.020	Fly
single organism behavior	GO:0044708	391	0.020
positive regulation of signaling	GO:0023056	243	0.020
protein ubiquitination	GO:0016567	70	0.020
positive regulation of rna metabolic process	GO:0051254	271	0.020	Human
mitotic dna integrity checkpoint	GO:0044774	75	0.019
regulation of cell fate commitment	GO:0010453	29	0.019
response to ecdysone	GO:0035075	34	0.019
regulation of anatomical structure morphogenesis	GO:0022603	242	0.019
dorsal ventral pattern formation	GO:0009953	133	0.018
protein complex assembly	GO:0006461	200	0.018
leg disc development	GO:0035218	92	0.018
response to endogenous stimulus	GO:0009719	119	0.018
peptidyl amino acid modification	GO:0018193	105	0.017
positive regulation of phosphate metabolic process	GO:0045937	139	0.017
protein complex biogenesis	GO:0070271	201	0.017
negative regulation of mitotic cell cycle	GO:0045930	109	0.017
dna damage checkpoint	GO:0000077	78	0.017
response to other organism	GO:0051707	293	0.017
ras protein signal transduction	GO:0007265	88	0.017
cellular catabolic process	GO:0044248	372	0.017
purine nucleotide metabolic process	GO:0006163	146	0.017
mapk cascade	GO:0000165	107	0.017
body morphogenesis	GO:0010171	2	0.017
small gtpase mediated signal transduction	GO:0007264	88	0.017
response to external biotic stimulus	GO:0043207	293	0.017
axis specification	GO:0009798	167	0.016
regulation of cellular amine metabolic process	GO:0033238	3	0.016
negative regulation of developmental process	GO:0051093	201	0.016
mating behavior	GO:0007617	106	0.016
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.016	Human Fly
regulation of protein modification process	GO:0031399	112	0.016
anterior posterior axis specification	GO:0009948	109	0.016
g2 dna damage checkpoint	GO:0031572	69	0.016
modification dependent macromolecule catabolic process	GO:0043632	79	0.016
negative regulation of response to stimulus	GO:0048585	258	0.016
glycosyl compound catabolic process	GO:1901658	112	0.016
positive regulation of cellular amine metabolic process	GO:0033240	0	0.016
cell motility	GO:0048870	251	0.016
cellular protein catabolic process	GO:0044257	83	0.016
anterior posterior pattern specification	GO:0009952	136	0.016
taxis	GO:0042330	304	0.016
axon guidance	GO:0007411	233	0.016
aromatic compound catabolic process	GO:0019439	166	0.015
response to biotic stimulus	GO:0009607	294	0.015
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.015
multi multicellular organism process	GO:0044706	123	0.015
meiosis i	GO:0007127	59	0.015
autophagic cell death	GO:0048102	83	0.015
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.015
carbohydrate derivative metabolic process	GO:1901135	217	0.015
negative regulation of cell cycle	GO:0045786	116	0.015
actin filament organization	GO:0007015	126	0.015
eye development	GO:0001654	323	0.015
connective tissue development	GO:0061448	3	0.015
modification dependent protein catabolic process	GO:0019941	78	0.015
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.015
death	GO:0016265	284	0.015
response to organic cyclic compound	GO:0014070	89	0.015
cognition	GO:0050890	141	0.014
negative regulation of transcription dna templated	GO:0045892	237	0.014	Human Fly
phagocytosis	GO:0006909	215	0.014
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.014
locomotory behavior	GO:0007626	176	0.014
carboxylic acid metabolic process	GO:0019752	92	0.014
negative regulation of cell cycle process	GO:0010948	109	0.014
ribonucleotide catabolic process	GO:0009261	109	0.014
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.014	Human
negative regulation of cell differentiation	GO:0045596	143	0.014
negative regulation of multicellular organismal process	GO:0051241	142	0.014
homeostatic process	GO:0042592	199	0.014
kidney development	GO:0001822	3	0.014
positive regulation of mapk cascade	GO:0043410	63	0.014
dna integrity checkpoint	GO:0031570	81	0.014
detection of stimulus involved in sensory perception	GO:0050906	92	0.014
cellular response to organic substance	GO:0071310	132	0.013
positive regulation of signal transduction	GO:0009967	223	0.013
regulation of embryonic development	GO:0045995	68	0.013
response to light stimulus	GO:0009416	124	0.013
macromolecule catabolic process	GO:0009057	161	0.013
regulation of catalytic activity	GO:0050790	185	0.013
intracellular signal transduction	GO:0035556	300	0.013
regulation of ras protein signal transduction	GO:0046578	93	0.013
heart development	GO:0007507	82	0.013
dna repair	GO:0006281	54	0.012
signal transduction by phosphorylation	GO:0023014	107	0.012
cellular ketone metabolic process	GO:0042180	24	0.012
tracheal outgrowth open tracheal system	GO:0007426	18	0.012
regulation of response to external stimulus	GO:0032101	115	0.012
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.012
apoptotic process	GO:0006915	159	0.012
positive regulation of phosphorus metabolic process	GO:0010562	139	0.012
wing disc pattern formation	GO:0035222	66	0.012
negative regulation of cell death	GO:0060548	81	0.012
gland development	GO:0048732	191	0.012
protein acetylation	GO:0006473	39	0.012
tissue morphogenesis	GO:0048729	297	0.011
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.011	Human Fly
histolysis	GO:0007559	102	0.011
regulation of cell differentiation	GO:0045595	302	0.011
ribose phosphate metabolic process	GO:0019693	145	0.011
cellular amino acid metabolic process	GO:0006520	61	0.011
purine nucleoside metabolic process	GO:0042278	127	0.011
cellular response to endogenous stimulus	GO:0071495	80	0.011
imaginal disc derived leg morphogenesis	GO:0007480	80	0.011
negative regulation of programmed cell death	GO:0043069	72	0.011
internal protein amino acid acetylation	GO:0006475	38	0.011
retina development in camera type eye	GO:0060041	4	0.011
positive regulation of developmental process	GO:0051094	143	0.011
regulation of neuron differentiation	GO:0045664	103	0.011
proteasomal protein catabolic process	GO:0010498	59	0.011
actin filament based process	GO:0030029	220	0.011
negative regulation of nervous system development	GO:0051961	92	0.011
g protein coupled receptor signaling pathway	GO:0007186	136	0.011
meiotic cell cycle process	GO:1903046	132	0.011
regulation of growth	GO:0040008	233	0.011
embryonic organ development	GO:0048568	50	0.011
cell migration	GO:0016477	238	0.011
gland morphogenesis	GO:0022612	145	0.011
regulation of developmental growth	GO:0048638	174	0.011
positive regulation of protein metabolic process	GO:0051247	128	0.011
carbohydrate derivative catabolic process	GO:1901136	118	0.011
positive regulation of cell communication	GO:0010647	250	0.011
salivary gland cell autophagic cell death	GO:0035071	83	0.011
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.011
sensory organ morphogenesis	GO:0090596	260	0.011
cardiovascular system development	GO:0072358	82	0.010
epithelial cell development	GO:0002064	274	0.010
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.010
cellular response to light stimulus	GO:0071482	37	0.010
protein modification by small protein conjugation	GO:0032446	79	0.010
cell proliferation	GO:0008283	299	0.010
localization of cell	GO:0051674	257	0.010
positive regulation of cellular protein metabolic process	GO:0032270	118	0.010
oxoacid metabolic process	GO:0043436	103	0.010
positive regulation of cellular component organization	GO:0051130	156	0.010
muscle organ development	GO:0007517	127	0.010
mitotic nuclear division	GO:0007067	213	0.010	Human

Sirt7 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.028
disease of cellular proliferation	DOID:14566	0.018
cancer	DOID:162	0.012
organ system cancer	DOID:0050686	0.012

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