Drosophila melanogaster

49 known processes

Hsp27 (Dmel_CG4466)

Heat shock protein 27

(Aliases: hsp 27,Dmel\CG4466,CG4466,hsp27,hsp-27,27K,28,Dhsp27,DmHsp27,HSP27,Hsp28,hsp28,hsp26,small hsp locus 67B,anon-WO0140519.69,HSP28,hsp27/26)

Hsp27 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
negative regulation of reactive oxygen species metabolic processGO:200037810.906
Rat
response to nutrient levelsGO:00316671140.732
negative regulation of response to stimulusGO:00485852580.705
defense response to bacteriumGO:00427421780.688
response to heatGO:0009408630.666
Rat Fly
macromolecular complex assemblyGO:00650032560.657
Human
cellular response to radiationGO:0071478520.656
response to abiotic stimulusGO:00096283410.602
Rat Fly
response to starvationGO:0042594970.565
defense responseGO:00069523000.530
response to extracellular stimulusGO:00099911160.509
negative regulation of signal transductionGO:00099682060.493
regulation of response to stressGO:00801342000.482
post embryonic appendage morphogenesisGO:00351203850.418
imaginal disc derived appendage morphogenesisGO:00351143950.405
determination of adult lifespanGO:00083401370.402
imaginal disc derived wing morphogenesisGO:00074763370.389
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281250.382
response to oxidative stressGO:0006979860.380
Rat Fly
response to hydrogen peroxideGO:0042542110.379
Rat
response to temperature stimulusGO:00092661060.368
Rat Fly
negative regulation of gene expressionGO:00106293870.360
programmed cell deathGO:00125012570.355
Human Rat
cellular macromolecular complex assemblyGO:00346221530.350
multicellular organismal agingGO:00102591400.346
cellular response to abiotic stimulusGO:0071214580.326
regulation of growthGO:00400082330.324
Rat
regulation of endopeptidase activityGO:0052548360.322
cellular response to ionizing radiationGO:0071479150.321
negative regulation of signalingGO:00230572190.320
heat shock mediated polytene chromosome puffingGO:003508070.317
response to reactive oxygen speciesGO:0000302240.316
Rat
positive regulation of macromolecule metabolic processGO:00106044050.316
negative regulation of cellular metabolic processGO:00313243820.315
Rat
regulation of cellular response to oxidative stressGO:190040740.307
behavioral response to starvationGO:004259560.306
positive regulation of biosynthetic processGO:00098913160.295
negative regulation of cellular response to oxidative stressGO:190040810.287
cellular response to heatGO:0034605240.271
regulation of cysteine type endopeptidase activityGO:2000116270.269
negative regulation of cell communicationGO:00106482230.253
positive regulation of macromolecule biosynthetic processGO:00105572830.251
response to virusGO:0009615280.242
cellular protein modification processGO:00064644380.241
apoptotic process involved in morphogenesisGO:006056130.235
wing disc morphogenesisGO:00074723440.233
negative regulation of response to oxidative stressGO:190288310.232
negative regulation of transcription dna templatedGO:00458922370.224
protein complex biogenesisGO:00702712010.223
Human
regulation of response to oxidative stressGO:190288240.223
regulation of cellular component biogenesisGO:00440872010.209
regulation of peptidase activityGO:0052547390.205
camera type eye morphogenesisGO:004859320.202
response to external biotic stimulusGO:00432072930.202
regulation of protein metabolic processGO:00512462560.196
negative regulation of biosynthetic processGO:00098902770.193
defense response to other organismGO:00985422250.191
agingGO:00075681430.188
response to ionizing radiationGO:0010212320.184
regulation of i kappab kinase nf kappab signalingGO:004312220.181
intracellular signal transductionGO:00355563000.180
Rat
negative regulation of cellular biosynthetic processGO:00313272770.178
transcription from rna polymerase ii promoterGO:00063663680.177
muscle system processGO:0003012210.175
Rat
epithelial cell differentiationGO:00308553220.174
positive regulation of cellular biosynthetic processGO:00313283160.173
regulation of multicellular organismal developmentGO:20000264140.170
homeostatic processGO:00425921990.170
cellular protein complex assemblyGO:0043623710.167
regulation of cellular protein metabolic processGO:00322682430.162
deathGO:00162652840.158
Human Rat
innate immune responseGO:00450871440.155
epithelial cell developmentGO:00020642740.153
establishment of localization in cellGO:00516494020.151
Human
cellular response to oxidative stressGO:0034599280.135
regulation of anatomical structure morphogenesisGO:00226032420.134
appendage developmentGO:00487364010.133
negative regulation of protein modification processGO:0031400290.133
response to alcoholGO:0097305950.132
Rat
embryonic morphogenesisGO:00485982060.131
regulation of defense responseGO:00313471020.130
camera type eye developmentGO:004301040.129
cold acclimationGO:000963180.129
Fly
protein modification processGO:00362114380.128
response to radiationGO:00093141550.126
regulation of apoptotic processGO:00429811300.125
Human Rat
response to other organismGO:00517072930.120
nucleocytoplasmic transportGO:0006913720.119
actin filament based processGO:00300292200.119
positive regulation of nucleic acid templated transcriptionGO:19035082660.119
regulation of proteolysisGO:0030162870.111
imaginal disc derived appendage developmentGO:00487373990.108
regulation of protein kinase activityGO:0045859510.105
mitotic spindle organizationGO:00070522200.103
response to bacteriumGO:00096171980.101
response to organic cyclic compoundGO:0014070890.101
Rat
regulation of transcription from rna polymerase ii promoterGO:00063573780.098
regulation of apoptotic signaling pathwayGO:2001233100.096
positive regulation of protein metabolic processGO:00512471280.093
appendage morphogenesisGO:00351073970.093
protein complex assemblyGO:00064612000.092
Human
regulation of protein phosphorylationGO:0001932640.092
intracellular transportGO:00469072280.092
Human
sensory perceptionGO:00076001960.091
Human
response to hypoxiaGO:0001666530.090
Fly
i kappab kinase nf kappab signalingGO:000724960.090
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.089
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.088
cellular response to gamma radiationGO:0071480100.088
regulation of reactive oxygen species metabolic processGO:200037780.087
Rat
positive regulation of cellular component biogenesisGO:0044089800.087
negative regulation of nitrogen compound metabolic processGO:00511722650.087
regulation of cellular response to stressGO:0080135890.086
organelle assemblyGO:00709251980.085
defense response to fungusGO:0050832480.084
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280230.084
phosphorylationGO:00163102940.081
Rat
neurological system processGO:00508773580.080
Human
regulation of protein modification processGO:00313991120.079
mrna splicing via spliceosomeGO:0000398730.076
cellular response to chemical stimulusGO:00708871990.075
actin filament organizationGO:00070151260.072
response to biotic stimulusGO:00096072940.072
stress activated mapk cascadeGO:0051403520.071
Rat
apoptotic processGO:00069151590.070
Human Rat
regulation of intracellular transportGO:0032386640.069
Human
protein maturationGO:0051604710.067
mrna metabolic processGO:00160711240.066
negative regulation of apoptotic processGO:0043066630.066
Human Rat
mrna processingGO:00063971040.066
response to organic substanceGO:00100332840.066
Rat
positive regulation of endopeptidase activityGO:0010950260.065
positive regulation of cellular protein metabolic processGO:00322701180.064
response to oxygen containing compoundGO:19017002000.064
Rat
positive regulation of transcription dna templatedGO:00458932660.063
multicellular organismal homeostasisGO:0048871410.063
regulation of molecular functionGO:00650092170.061
negative regulation of developmental processGO:00510932010.060
muscle contractionGO:0006936130.060
Rat
positive regulation of nitrogen compound metabolic processGO:00511733540.060
regulation of response to external stimulusGO:00321011150.058
regulation of hydrolase activityGO:0051336970.056
negative regulation of cellular protein metabolic processGO:0032269850.056
protein phosphorylationGO:00064681690.055
regulation of catalytic activityGO:00507901850.055
nuclear importGO:0051170510.054
negative regulation of cell deathGO:0060548810.053
Human Rat
regulation of localizationGO:00328792750.052
Human
rna processingGO:00063961470.052
epithelial cell migrationGO:00106311480.050
regulation of transferase activityGO:0051338580.050
regulation of cell cycle g1 s phase transitionGO:1902806230.050
proteolysisGO:00065081920.050
positive regulation of hydrolase activityGO:0051345780.050
anatomical structure homeostasisGO:0060249970.049
regulation of programmed cell deathGO:00430671520.049
Human Rat
negative regulation of catalytic activityGO:0043086420.047
vesicle mediated transportGO:00161923810.047
organic substance catabolic processGO:19015753080.047
negative regulation of programmed cell deathGO:0043069720.046
Human Rat
regulation of developmental growthGO:00486381740.046
response to woundingGO:0009611940.046
response to endogenous stimulusGO:00097191190.045
Rat
negative regulation of intracellular signal transductionGO:1902532570.045
positive regulation of nucleobase containing compound metabolic processGO:00459353320.044
response to decreased oxygen levelsGO:0036293580.043
Fly
growthGO:00400073590.043
Rat
regulation of phosphate metabolic processGO:00192202100.041
regulation of transportGO:00510491810.041
Human
morphogenesis of an epitheliumGO:00020092760.041
muscle organ developmentGO:00075171270.041
positive regulation of multicellular organismal processGO:00512401430.041
muscle structure developmentGO:00610612240.041
enzyme linked receptor protein signaling pathwayGO:00071671790.041
actin cytoskeleton organizationGO:00300362060.040
rna splicingGO:0008380830.040
chromatin silencingGO:0006342760.040
regulation of cell cycleGO:00517262910.040
regulation of phosphorus metabolic processGO:00511742100.039
apoptotic signaling pathwayGO:0097190270.039
protein catabolic processGO:00301631010.039
regulation of gene silencingGO:0060968630.039
wound healingGO:0042060750.038
regulation of multi organism processGO:00439001310.038
regulation of intracellular signal transductionGO:19025312360.038
negative regulation of protein metabolic processGO:0051248850.038
apoptotic process involved in developmentGO:1902742200.037
response to inorganic substanceGO:0010035440.037
Rat
regulation of phosphorylationGO:00423251470.037
defense response to gram negative bacteriumGO:0050829940.037
protein modification by small protein conjugation or removalGO:00706471060.036
nitrogen compound transportGO:0071705850.036
protein k48 linked ubiquitinationGO:007093630.036
regulation of cell differentiationGO:00455953020.036
cell migrationGO:00164772380.036
cellular catabolic processGO:00442483720.035
positive regulation of rna metabolic processGO:00512542710.035
single organism nuclear importGO:1902593510.035
cellular lipid metabolic processGO:0044255830.034
sensory perception of light stimulusGO:0050953120.034
Human
cell growthGO:00160491080.034
Rat
positive regulation of catalytic activityGO:00430851180.034
regulation of innate immune responseGO:0045088710.034
positive regulation of developmental processGO:00510941430.033
molting cycleGO:0042303560.033
negative regulation of protein processingGO:0010955310.033
cellular response to organic substanceGO:00713101320.032
negative regulation of kinase activityGO:0033673160.032
visual perceptionGO:000760190.032
Human
catabolic processGO:00090564090.031
negative regulation of transferase activityGO:0051348180.031
positive regulation of cell communicationGO:00106472500.031
regionalizationGO:00030024160.031
protein localizationGO:00081042840.030
developmental maturationGO:00217001720.030
negative regulation of growthGO:0045926840.030
Rat
positive regulation of growthGO:0045927750.030
cell deathGO:00082192790.030
Human Rat
embryonic organ developmentGO:0048568500.030
regulation of autophagyGO:0010506620.029
nuclear transportGO:0051169720.029
developmental programmed cell deathGO:00106231380.029
negative regulation of rna biosynthetic processGO:19026792400.029
cellular response to dna damage stimulusGO:00069742230.029
positive regulation of apoptotic signaling pathwayGO:200123540.028
connective tissue developmentGO:006144830.028
protein targeting to nucleusGO:0044744510.028
negative regulation of multicellular organismal processGO:00512411420.028
intrinsic apoptotic signaling pathwayGO:0097193160.028
regulation of protein serine threonine kinase activityGO:0071900250.027
protein processingGO:0016485680.027
protein ubiquitinationGO:0016567700.026
negative regulation of endopeptidase activityGO:0010951110.026
eye developmentGO:00016543230.026
cell motilityGO:00488702510.025
negative regulation of macromolecule biosynthetic processGO:00105582700.025
regulation of cell deathGO:00109411730.025
Human Rat
eye morphogenesisGO:00485922600.025
embryo development ending in birth or egg hatchingGO:00097921520.025
localization of cellGO:00516742570.025
ameboidal type cell migrationGO:00016671510.025
negative regulation of phosphate metabolic processGO:0045936450.024
negative regulation of cell differentiationGO:00455961430.024
chromosome organizationGO:00512763600.024
response to gamma radiationGO:0010332170.024
microtubule polymerization or depolymerizationGO:0031109390.024
Rat
positive regulation of rna biosynthetic processGO:19026802660.023
negative regulation of protein phosphorylationGO:0001933170.023
protein importGO:0017038550.023
reactive oxygen species metabolic processGO:0072593220.023
Rat
multi organism reproductive behaviorGO:00447051210.023
response to nitrogen compoundGO:1901698900.023
negative regulation of molecular functionGO:0044092510.023
negative regulation of transcription from rna polymerase ii promoterGO:00001221190.022
jak stat cascadeGO:0007259490.022
positive regulation of cell deathGO:0010942690.022
microtubule organizing center organizationGO:00310231680.022
regulation of response to biotic stimulusGO:0002831630.021
activation of cysteine type endopeptidase activity involved in apoptotic processGO:0006919160.021
intracellular protein transportGO:00068861040.021
positive regulation of response to stimulusGO:00485843230.021
response to organonitrogen compoundGO:0010243750.021
protein deubiquitinationGO:0016579170.021
regulation of kinase activityGO:0043549530.021
rna splicing via transesterification reactionsGO:0000375730.021
regulation of cell cycle processGO:00105641810.021
regulation of nervous system developmentGO:00519602480.021
brain developmentGO:00074201200.020
regulation of catabolic processGO:00098941700.020
macromolecule catabolic processGO:00090571610.020
tissue homeostasisGO:0001894360.020
columnar cuboidal epithelial cell developmentGO:00020662490.020
regulation of g1 s transition of mitotic cell cycleGO:2000045230.020
positive regulation of phosphorylationGO:0042327870.020
muscle cell differentiationGO:00426921030.020
negative regulation of peptidase activityGO:0010466110.020
larval developmentGO:00021641040.019
positive regulation of developmental growthGO:0048639620.019
rna splicing via transesterification reactions with bulged adenosine as nucleophileGO:0000377730.019
immune system processGO:00023763470.019
columnar cuboidal epithelial cell differentiationGO:00020652560.019
positive regulation of signal transductionGO:00099672230.018
positive regulation of cell migrationGO:003033520.018
cellular amide metabolic processGO:0043603800.018
compound eye morphogenesisGO:00017452490.018
cell agingGO:000756920.018
regulation of immune responseGO:00507761180.018
positive regulation of peptidase activityGO:0010952290.018
antimicrobial peptide productionGO:0002775460.018
spermatogenesisGO:00072832000.018
regulation of meiosisGO:004002030.017
regulation of defense response to virus by hostGO:0050691100.017
biosynthetic process of antibacterial peptides active against gram negative bacteriaGO:0002812140.017
positive regulation of phosphorus metabolic processGO:00105621390.017
regulation of system processGO:0044057360.017
Rat
synaptic transmissionGO:00072682880.017
adult chitin containing cuticle pigmentationGO:0048085160.017
taxisGO:00423303040.016
ion transportGO:00068111450.016
positive regulation of phosphate metabolic processGO:00459371390.016
antimicrobial humoral responseGO:0019730990.016
dna damage checkpointGO:0000077780.016
negative regulation of phosphorylationGO:0042326350.016
chromatin remodelingGO:0006338720.016
establishment of protein localizationGO:00451841630.015
defense response to virusGO:0051607230.015
response to growth factorGO:0070848310.015
positive regulation of programmed cell deathGO:0043068620.015
positive regulation of cysteine type endopeptidase activityGO:2001056240.015
negative regulation of nucleic acid templated transcriptionGO:19035072400.015
regulation of defense response to bacteriumGO:1900424300.015
activation of cysteine type endopeptidase activityGO:0097202170.015
establishment of rna localizationGO:0051236470.015
chemotaxisGO:00069352490.015
negative regulation of nucleobase containing compound metabolic processGO:00459342610.015
cell cycle arrestGO:000705040.015
negative regulation of protein maturationGO:1903318310.014
central nervous system developmentGO:00074172010.014
negative regulation of cysteine type endopeptidase activity involved in apoptotic processGO:004315420.014
endocytosisGO:00068973100.014
retina development in camera type eyeGO:006004140.014
cuticle developmentGO:0042335860.014
heterochromatin organizationGO:0070828250.014
negative regulation of defense responseGO:0031348350.014
regulation of synapse structure and activityGO:00508031280.013
mapk cascadeGO:00001651070.013
Rat
ribonucleoprotein complex assemblyGO:0022618230.013
response to oxygen levelsGO:0070482590.013
Fly
humoral immune responseGO:00069591170.013
stress activated protein kinase signaling cascadeGO:0031098550.013
Rat
regulation of cell cycle phase transitionGO:19019871300.013
positive regulation of apoptotic processGO:0043065470.013
response to uvGO:0009411240.013
sensory organ morphogenesisGO:00905962600.013
chromatin assembly or disassemblyGO:0006333520.013
positive regulation of i kappab kinase nf kappab signalingGO:004312310.013
regulation of nucleocytoplasmic transportGO:0046822350.013
spindle assemblyGO:0051225800.013
positive regulation of gene expressionGO:00106282900.012
positive regulation of protein modification processGO:0031401580.012
cellular response to growth factor stimulusGO:0071363300.012
centrosome organizationGO:00512971630.012
protein modification by small protein conjugationGO:0032446790.012
negative regulation of rna metabolic processGO:00512532510.012
response to hormoneGO:0009725450.012
Rat
forebrain developmentGO:003090020.012
organophosphate catabolic processGO:00464341120.012
response to lipidGO:0033993380.012
Rat
cellular protein catabolic processGO:0044257830.012
digestive tract morphogenesisGO:00485461270.012
spindle organizationGO:00070512530.012
cardiovascular system developmentGO:0072358820.011
positive regulation of molecular functionGO:00440931360.011
regulation of immune system processGO:00026821760.011
positive regulation of defense responseGO:0031349590.011
signal transduction by phosphorylationGO:00230141070.011
Rat
regulation of mitotic cell cycle phase transitionGO:19019901300.011
cytoplasmic transportGO:00164821300.011
regulation of synapse organizationGO:00508071100.011
regulation of cell developmentGO:00602842150.011
reproductive behaviorGO:00190981220.011
lipid metabolic processGO:00066291210.011
regulation of notch signaling pathwayGO:00085931000.011
organic substance transportGO:00717022570.011
negative regulation of phosphorus metabolic processGO:0010563450.011
positive regulation of signalingGO:00230562430.011
regulation of mitotic cell cycleGO:00073461900.011
positive regulation of catabolic processGO:00098961050.011
protein import into nucleusGO:0006606510.011
tissue migrationGO:00901301550.011
positive regulation of protein localization to nucleusGO:1900182210.010
chaeta developmentGO:0022416970.010
regulation of protein processingGO:0070613320.010
antibacterial humoral responseGO:0019731440.010
regulation of antibacterial peptide productionGO:0002786220.010
protein oligomerizationGO:0051259160.010
Human
nuclear divisionGO:00002803320.010
regulation of nucleotide metabolic processGO:0006140620.010
protein modification by small protein removalGO:0070646280.010
molting cycle chitin based cuticleGO:0007591560.010
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressGO:007005940.010
organophosphate metabolic processGO:00196371950.010
cellular response to extracellular stimulusGO:0031668640.010
cellular response to arsenic containing substanceGO:007124360.010

Hsp27 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
motor neuron diseaseDOID:23100.784
Human
disease of anatomical entityDOID:700.784
Human
central nervous system diseaseDOID:33100.784
Human
neurodegenerative diseaseDOID:128900.784
Human
nervous system diseaseDOID:86300.784
Human
distal hereditary motor neuropathyDOID:005058200.650
Human
motor neuritisDOID:68300.650
Human
charcot marie tooth disease type 2DOID:005053900.623
Human
neuropathyDOID:87000.623
Human
charcot marie tooth diseaseDOID:1059500.623
Human
neuromuscular diseaseDOID:44000.623
Human
muscular diseaseDOID:008000000.213
musculoskeletal system diseaseDOID:1700.213
cardiovascular system diseaseDOID:128700.117
muscle tissue diseaseDOID:6600.068
sensory system diseaseDOID:005015500.041
eye and adnexa diseaseDOID:149200.041
myopathyDOID:42300.033
cardiomyopathyDOID:005070000.011
heart diseaseDOID:11400.011
intrinsic cardiomyopathyDOID:006003600.011
dilated cardiomyopathyDOID:1293000.011