IMP: Integrative Multi-species Prediction

Drosophila melanogaster

10 known processes

Hsp23 (Dmel_CG4463)

Heat shock protein 23

(Aliases: CG4463,23,hsp23,Hsp-23,HSP23/IAP,DmHsp23,HSP23,hsp23/22,hsp 23,hsp 23K,Dmel\CG4463,small hsp locus 67B,hsp 22K)

Entrez: 39077
FLYBASE: FBgn0001224
UniProtKB: M9NE68
UniProtKB: P02516

Process Predictions
Disease Predictions

Hsp23 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
appendage development	GO:0048736	401	0.655	Fly
negative regulation of reactive oxygen species metabolic process	GO:2000378	1	0.622	Rat
imaginal disc derived appendage development	GO:0048737	399	0.548	Fly
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.546	Fly
wing disc morphogenesis	GO:0007472	344	0.539	Fly
response to temperature stimulus	GO:0009266	106	0.459
response to heat	GO:0009408	63	0.370	Rat Fly
post embryonic appendage morphogenesis	GO:0035120	385	0.327	Fly
response to hydrogen peroxide	GO:0042542	11	0.326	Mouse Rat
appendage morphogenesis	GO:0035107	397	0.317	Fly
apoptotic process involved in morphogenesis	GO:0060561	3	0.294	Mouse
imaginal disc derived wing morphogenesis	GO:0007476	337	0.253	Fly
glutathione metabolic process	GO:0006749	37	0.209
defense response to bacterium	GO:0042742	178	0.182	Fly
growth	GO:0040007	359	0.179	Rat
defense response	GO:0006952	300	0.168	Fly
response to fungus	GO:0009620	50	0.161	Fly
epithelial cell differentiation	GO:0030855	322	0.153
response to endogenous stimulus	GO:0009719	119	0.146	Rat
response to bacterium	GO:0009617	198	0.119	Fly
cellular response to ionizing radiation	GO:0071479	15	0.119
heat shock mediated polytene chromosome puffing	GO:0035080	7	0.115
response to other organism	GO:0051707	293	0.112	Fly
cellular amide metabolic process	GO:0043603	80	0.108
negative regulation of cellular metabolic process	GO:0031324	382	0.107	Mouse Rat
defense response to other organism	GO:0098542	225	0.106	Fly
response to extracellular stimulus	GO:0009991	116	0.102	Fly
regulation of growth	GO:0040008	233	0.097	Rat
cellular modified amino acid metabolic process	GO:0006575	45	0.089
response to cold	GO:0009409	13	0.088
negative regulation of biosynthetic process	GO:0009890	277	0.086
response to abiotic stimulus	GO:0009628	341	0.083
regulation of protein metabolic process	GO:0051246	256	0.079	Mouse
response to reactive oxygen species	GO:0000302	24	0.076	Mouse Rat
macromolecular complex assembly	GO:0065003	256	0.075	Human Mouse
behavioral response to starvation	GO:0042595	6	0.075	Fly
cold acclimation	GO:0009631	8	0.074
chemotaxis	GO:0006935	249	0.071
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.069	Mouse
cellular protein complex assembly	GO:0043623	71	0.067	Mouse
intracellular signal transduction	GO:0035556	300	0.067	Mouse Rat
peptide metabolic process	GO:0006518	80	0.067
establishment of localization in cell	GO:0051649	402	0.065	Human
taxis	GO:0042330	304	0.065
actin cytoskeleton organization	GO:0030036	206	0.063
camera type eye morphogenesis	GO:0048593	2	0.063
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.062
camera type eye development	GO:0043010	4	0.061	Mouse
sensory perception	GO:0007600	196	0.061	Human
cellular response to gamma radiation	GO:0071480	10	0.059
stress activated mapk cascade	GO:0051403	52	0.058	Rat
positive regulation of macromolecule metabolic process	GO:0010604	405	0.057	Mouse
regulation of response to external stimulus	GO:0032101	115	0.056
intracellular transport	GO:0046907	228	0.056	Human
response to nutrient levels	GO:0031667	114	0.056	Fly
negative regulation of response to stimulus	GO:0048585	258	0.055	Mouse
negative regulation of rna biosynthetic process	GO:1902679	240	0.055
transcription from rna polymerase ii promoter	GO:0006366	368	0.055
regulation of cell death	GO:0010941	173	0.055	Human Mouse Rat
negative regulation of endopeptidase activity	GO:0010951	11	0.054	Mouse
detection of abiotic stimulus	GO:0009582	66	0.054
positive regulation of cell motility	GO:2000147	3	0.054
multicellular organismal aging	GO:0010259	140	0.054	Fly
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.054
death	GO:0016265	284	0.054	Human Mouse Rat
regulation of cellular protein metabolic process	GO:0032268	243	0.053	Mouse
phosphorylation	GO:0016310	294	0.053	Mouse Rat
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.052
response to external biotic stimulus	GO:0043207	293	0.051	Fly
response to radiation	GO:0009314	155	0.051
regulation of cell growth	GO:0001558	43	0.051	Rat
regulation of cysteine type endopeptidase activity	GO:2000116	27	0.050	Mouse
regulation of programmed cell death	GO:0043067	152	0.049	Human Mouse Rat
sulfur compound metabolic process	GO:0006790	59	0.048
epithelial cell development	GO:0002064	274	0.047
regulation of intracellular signal transduction	GO:1902531	236	0.047	Mouse
cell growth	GO:0016049	108	0.047	Rat
negative regulation of cellular response to oxidative stress	GO:1900408	1	0.046	Mouse
response to biotic stimulus	GO:0009607	294	0.045	Fly
actin filament based process	GO:0030029	220	0.045
negative regulation of cell death	GO:0060548	81	0.045	Human Mouse Rat
aging	GO:0007568	143	0.043	Rat Fly
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.043
sensory perception of light stimulus	GO:0050953	12	0.043	Human
regulation of behavior	GO:0050795	75	0.043
translation	GO:0006412	69	0.042
apoptotic process	GO:0006915	159	0.042	Human Mouse Rat
cellular response to radiation	GO:0071478	52	0.041
programmed cell death	GO:0012501	257	0.041	Human Mouse Rat
negative regulation of cellular biosynthetic process	GO:0031327	277	0.041
regulation of response to stress	GO:0080134	200	0.041	Mouse
positive regulation of response to external stimulus	GO:0032103	44	0.041
detection of stimulus	GO:0051606	156	0.041
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	25	0.041	Mouse
defense response to fungus	GO:0050832	48	0.040	Fly
regulation of response to oxidative stress	GO:1902882	4	0.040	Mouse
regulation of apoptotic process	GO:0042981	130	0.040	Human Mouse Rat
negative regulation of cell communication	GO:0010648	223	0.040	Mouse
regulation of multicellular organismal development	GO:2000026	414	0.039
eye morphogenesis	GO:0048592	260	0.039
response to ionizing radiation	GO:0010212	32	0.038
cellular protein modification process	GO:0006464	438	0.038	Mouse
negative regulation of peptidase activity	GO:0010466	11	0.037	Mouse
positive regulation of cell migration	GO:0030335	2	0.037
cellular response to heat	GO:0034605	24	0.037
rna localization	GO:0006403	115	0.037
detection of external stimulus	GO:0009581	66	0.037
muscle system process	GO:0003012	21	0.036	Rat
protein phosphorylation	GO:0006468	169	0.036	Mouse
signal transduction by phosphorylation	GO:0023014	107	0.035	Rat
protein complex assembly	GO:0006461	200	0.035	Human Mouse
regulation of intracellular transport	GO:0032386	64	0.034	Human
oxoacid metabolic process	GO:0043436	103	0.033
negative regulation of apoptotic process	GO:0043066	63	0.033	Human Mouse Rat
response to organic cyclic compound	GO:0014070	89	0.033	Rat
dna damage checkpoint	GO:0000077	78	0.033
tissue homeostasis	GO:0001894	36	0.032
response to organic substance	GO:0010033	284	0.032	Rat
cellular amino acid metabolic process	GO:0006520	61	0.032
regulation of translation	GO:0006417	56	0.032
regulation of phosphorus metabolic process	GO:0051174	210	0.032	Mouse
negative regulation of growth	GO:0045926	84	0.032	Rat
response to oxygen containing compound	GO:1901700	200	0.031	Mouse Rat
regulation of cellular response to stress	GO:0080135	89	0.031	Mouse
regulation of cell cycle phase transition	GO:1901987	130	0.031
reactive oxygen species metabolic process	GO:0072593	22	0.031	Rat
response to hypoxia	GO:0001666	53	0.030
protein complex biogenesis	GO:0070271	201	0.030	Human Mouse
muscle organ development	GO:0007517	127	0.030	Mouse
microtubule polymerization or depolymerization	GO:0031109	39	0.030	Rat
negative regulation of gene expression	GO:0010629	387	0.030	Mouse
negative regulation of response to oxidative stress	GO:1902883	1	0.029	Mouse
regulation of system process	GO:0044057	36	0.029	Rat
muscle structure development	GO:0061061	224	0.029	Mouse
regulation of transport	GO:0051049	181	0.029	Human
response to oxidative stress	GO:0006979	86	0.029	Mouse Rat Fly
negative regulation of transcription dna templated	GO:0045892	237	0.029
columnar cuboidal epithelial cell development	GO:0002066	249	0.028
stress activated protein kinase signaling cascade	GO:0031098	55	0.028	Rat
regulation of cell differentiation	GO:0045595	302	0.028
biological adhesion	GO:0022610	138	0.028
response to alcohol	GO:0097305	95	0.027	Rat
autophagy	GO:0006914	108	0.027
cell cycle checkpoint	GO:0000075	95	0.027
response to light stimulus	GO:0009416	124	0.027
spermatogenesis	GO:0007283	200	0.027
muscle contraction	GO:0006936	13	0.027	Rat
male courtship behavior	GO:0008049	63	0.026
rna processing	GO:0006396	147	0.026
regulation of molecular function	GO:0065009	217	0.026	Mouse
actin filament organization	GO:0007015	126	0.026
negative regulation of signal transduction	GO:0009968	206	0.025	Mouse
regulation of anatomical structure morphogenesis	GO:0022603	242	0.025
visual perception	GO:0007601	9	0.025	Human
response to nitrogen compound	GO:1901698	90	0.025
anatomical structure homeostasis	GO:0060249	97	0.025
response to starvation	GO:0042594	97	0.024	Fly
mitotic dna integrity checkpoint	GO:0044774	75	0.024
organonitrogen compound metabolic process	GO:1901564	318	0.024
homeostatic process	GO:0042592	199	0.023
multicellular organismal homeostasis	GO:0048871	41	0.023
cellular macromolecular complex assembly	GO:0034622	153	0.023	Mouse
determination of adult lifespan	GO:0008340	137	0.023	Fly
negative regulation of programmed cell death	GO:0043069	72	0.023	Human Mouse Rat
sensory organ morphogenesis	GO:0090596	260	0.023
organic acid metabolic process	GO:0006082	103	0.023
regulation of cell cycle process	GO:0010564	181	0.023
posttranscriptional regulation of gene expression	GO:0010608	145	0.022
g2 dna damage checkpoint	GO:0031572	69	0.022
cell cycle phase transition	GO:0044770	140	0.022
regulation of chemotaxis	GO:0050920	12	0.022
positive regulation of biosynthetic process	GO:0009891	316	0.022	Mouse
response to wounding	GO:0009611	94	0.022
mitotic g2 dna damage checkpoint	GO:0007095	69	0.022
jak stat cascade	GO:0007259	49	0.021
mitotic g2 m transition checkpoint	GO:0044818	70	0.021
cellular response to organic substance	GO:0071310	132	0.021
negative regulation of protein metabolic process	GO:0051248	85	0.021	Mouse
neurological system process	GO:0050877	358	0.020	Human
regulation of reactive oxygen species metabolic process	GO:2000377	8	0.020	Rat
regulation of epithelial cell migration	GO:0010632	12	0.020
regulation of localization	GO:0032879	275	0.020	Human
cellular response to oxidative stress	GO:0034599	28	0.020	Mouse
polytene chromosome puffing	GO:0035079	7	0.019
negative regulation of transferase activity	GO:0051348	18	0.019	Mouse
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.019
ameboidal type cell migration	GO:0001667	151	0.019
regulation of defense response	GO:0031347	102	0.019
amine metabolic process	GO:0009308	12	0.019
response to gamma radiation	GO:0010332	17	0.019
regionalization	GO:0003002	416	0.019
mitotic nuclear division	GO:0007067	213	0.019
mitotic cell cycle checkpoint	GO:0007093	88	0.018
cell maturation	GO:0048469	144	0.018
positive regulation of cellular protein metabolic process	GO:0032270	118	0.018
negative regulation of cell cycle	GO:0045786	116	0.018
positive regulation of signal transduction	GO:0009967	223	0.018
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.018
cellular response to abiotic stimulus	GO:0071214	58	0.018
single organism behavior	GO:0044708	391	0.018
negative regulation of intracellular signal transduction	GO:1902532	57	0.018	Mouse
cell adhesion	GO:0007155	136	0.018
cellular response to chemical stimulus	GO:0070887	199	0.018	Mouse
regulation of transferase activity	GO:0051338	58	0.017	Mouse
regulation of proteolysis	GO:0030162	87	0.017	Mouse
regulation of cellular ketone metabolic process	GO:0010565	3	0.017
small molecule metabolic process	GO:0044281	305	0.017
synapse organization	GO:0050808	196	0.017
negative regulation of kinase activity	GO:0033673	16	0.017	Mouse
pole plasm rna localization	GO:0007316	52	0.017
dna integrity checkpoint	GO:0031570	81	0.017
spermatid development	GO:0007286	98	0.017
positive regulation of developmental process	GO:0051094	143	0.017
positive regulation of signaling	GO:0023056	243	0.017
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.016
single organismal cell cell adhesion	GO:0016337	45	0.016
cellular amine metabolic process	GO:0044106	12	0.016
oocyte axis specification	GO:0007309	108	0.016
negative regulation of cell cycle phase transition	GO:1901988	103	0.016
negative regulation of signaling	GO:0023057	219	0.016	Mouse
developmental programmed cell death	GO:0010623	138	0.016	Mouse
carboxylic acid metabolic process	GO:0019752	92	0.016
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.016
mitotic dna damage checkpoint	GO:0044773	74	0.016
somatic muscle development	GO:0007525	66	0.016
histolysis	GO:0007559	102	0.016
positive regulation of response to stimulus	GO:0048584	323	0.016
regulation of hydrolase activity	GO:0051336	97	0.016	Mouse
negative regulation of rna metabolic process	GO:0051253	251	0.016
body morphogenesis	GO:0010171	2	0.016
positive regulation of multi organism process	GO:0043902	40	0.016
regulation of phosphate metabolic process	GO:0019220	210	0.016	Mouse
embryonic morphogenesis	GO:0048598	206	0.016
mesenchymal cell differentiation	GO:0048762	1	0.016
single organism cell adhesion	GO:0098602	47	0.016
regulation of catalytic activity	GO:0050790	185	0.015	Mouse
larval development	GO:0002164	104	0.015
open tracheal system development	GO:0007424	204	0.015
regulation of protein modification process	GO:0031399	112	0.015	Mouse
mitotic cell cycle phase transition	GO:0044772	138	0.015
positive regulation of cellular biosynthetic process	GO:0031328	316	0.015	Mouse
forebrain development	GO:0030900	2	0.015
dorsal ventral pattern formation	GO:0009953	133	0.014
negative regulation of phosphate metabolic process	GO:0045936	45	0.014	Mouse
negative regulation of cell differentiation	GO:0045596	143	0.014
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.014
embryonic pattern specification	GO:0009880	174	0.014
response to lipopolysaccharide	GO:0032496	4	0.014
intracellular mrna localization involved in pattern specification process	GO:0060810	56	0.014
cell death	GO:0008219	279	0.014	Human Mouse Rat
positive regulation of multicellular organismal process	GO:0051240	143	0.014	Mouse
response to organonitrogen compound	GO:0010243	75	0.014
proteolysis	GO:0006508	192	0.014	Mouse
response to methotrexate	GO:0031427	11	0.014
regulation of mitotic cell cycle	GO:0007346	190	0.014
axis specification	GO:0009798	167	0.014
salivary gland cell autophagic cell death	GO:0035071	83	0.013
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.013
spinal cord development	GO:0021510	1	0.013
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.013
wound healing	GO:0042060	75	0.013
positive regulation of chemotaxis	GO:0050921	2	0.013
oocyte differentiation	GO:0009994	145	0.013
response to virus	GO:0009615	28	0.013
regulation of cell cycle	GO:0051726	291	0.013
detection of light stimulus	GO:0009583	58	0.013
positive regulation of cellular amine metabolic process	GO:0033240	0	0.013
regulation of cellular amine metabolic process	GO:0033238	3	0.013
salivary gland histolysis	GO:0035070	88	0.013
positive regulation of phosphorus metabolic process	GO:0010562	139	0.013
mapk cascade	GO:0000165	107	0.013	Rat
limb development	GO:0060173	1	0.012
cytoplasmic transport	GO:0016482	130	0.012
regulation of multi organism process	GO:0043900	131	0.012
chromosome organization	GO:0051276	360	0.012
regulation of autophagy	GO:0010506	62	0.012
protein processing	GO:0016485	68	0.012	Mouse
negative regulation of mitotic cell cycle	GO:0045930	109	0.012
response to uv	GO:0009411	24	0.012
leg disc morphogenesis	GO:0007478	80	0.012
cellular response to extracellular stimulus	GO:0031668	64	0.012
regulation of cellular component biogenesis	GO:0044087	201	0.012
organic substance transport	GO:0071702	257	0.012
negative regulation of defense response	GO:0031348	35	0.012
regulation of cell development	GO:0060284	215	0.012
compound eye development	GO:0048749	307	0.012
phosphatidylethanolamine metabolic process	GO:0046337	1	0.012
tissue death	GO:0016271	102	0.012
mushroom body development	GO:0016319	70	0.012
regulation of phosphorylation	GO:0042325	147	0.012	Mouse
pigment biosynthetic process	GO:0046148	36	0.012
limb morphogenesis	GO:0035108	1	0.012
cellular response to nitrogen compound	GO:1901699	51	0.012
response to organophosphorus	GO:0046683	2	0.012
developmental maturation	GO:0021700	172	0.011
cellular biogenic amine catabolic process	GO:0042402	1	0.011
positive regulation of cell death	GO:0010942	69	0.011
imaginal disc derived leg morphogenesis	GO:0007480	80	0.011
epithelium migration	GO:0090132	148	0.011
macromolecule catabolic process	GO:0009057	161	0.011
negative regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043154	2	0.011	Mouse
memory	GO:0007613	94	0.011
lipopolysaccharide mediated signaling pathway	GO:0031663	1	0.011
cell cycle arrest	GO:0007050	4	0.011
embryonic organ development	GO:0048568	50	0.011
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.011	Mouse
positive regulation of cell communication	GO:0010647	250	0.011
gtp metabolic process	GO:0046039	72	0.011
positive regulation of melanization defense response	GO:0035008	1	0.011
negative regulation of molecular function	GO:0044092	51	0.011	Mouse
innate immune response	GO:0045087	144	0.011
apoptotic signaling pathway	GO:0097190	27	0.011	Mouse
catabolic process	GO:0009056	409	0.011
pole plasm oskar mrna localization	GO:0045451	46	0.011
positive regulation of rna biosynthetic process	GO:1902680	266	0.011
response to growth factor	GO:0070848	31	0.011
regulation of body fluid levels	GO:0050878	14	0.010
cellular response to oxygen containing compound	GO:1901701	79	0.010
response to endoplasmic reticulum stress	GO:0034976	28	0.010
phagocytosis	GO:0006909	215	0.010
regulation of defense response to bacterium	GO:1900424	30	0.010
cellular response to biotic stimulus	GO:0071216	4	0.010
adult behavior	GO:0030534	137	0.010
negative regulation of developmental process	GO:0051093	201	0.010
positive regulation of phosphate metabolic process	GO:0045937	139	0.010
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.010
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.010
salivary gland morphogenesis	GO:0007435	145	0.010

Hsp23 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability	Func Analog Org
neuropathy	DOID:870	0.529	Human
charcot marie tooth disease	DOID:10595	0.529	Human
nervous system disease	DOID:863	0.529	Human
disease of anatomical entity	DOID:7	0.529	Human
charcot marie tooth disease type 2	DOID:0050539	0.529	Human
neuromuscular disease	DOID:440	0.529	Human
central nervous system disease	DOID:331	0.358	Human
motor neuron disease	DOID:231	0.358	Human
neurodegenerative disease	DOID:1289	0.358	Human
musculoskeletal system disease	DOID:17	0.103
cardiovascular system disease	DOID:1287	0.103
muscle tissue disease	DOID:66	0.098
muscular disease	DOID:0080000	0.098
cardiomyopathy	DOID:0050700	0.067
heart disease	DOID:114	0.067
intrinsic cardiomyopathy	DOID:0060036	0.067
myopathy	DOID:423	0.067
eye disease	DOID:5614	0.066
eye and adnexa disease	DOID:1492	0.066
sensory system disease	DOID:0050155	0.066
dilated cardiomyopathy	DOID:12930	0.025
disease of cellular proliferation	DOID:14566	0.012
cancer	DOID:162	0.012

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