Drosophila melanogaster

138 known processes

heph (Dmel_CG31000)

hephaestus

(Aliases: dmPTB,CG2094,ema,dPTB,Dmel\CG31000,CG31000,ptb,Ptb,PTB,CG2290,l(3)j11B9,l(3)03429)

heph biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.981
imaginal disc derived appendage developmentGO:00487373990.964
imaginal disc derived appendage morphogenesisGO:00351143950.963
regulation of transcription from rna polymerase ii promoterGO:00063573780.920
positive regulation of gene expressionGO:00106282900.905
appendage developmentGO:00487364010.891
imaginal disc derived wing morphogenesisGO:00074763370.872
negative regulation of gene expressionGO:00106293870.872
negative regulation of biosynthetic processGO:00098902770.861
spermatogenesisGO:00072832000.858
spermatid differentiationGO:00485151140.846
post embryonic appendage morphogenesisGO:00351203850.839
forebrain developmentGO:003090020.836
wing disc morphogenesisGO:00074723440.834
spermatid developmentGO:0007286980.817
negative regulation of transcription from rna polymerase ii promoterGO:00001221190.809
appendage morphogenesisGO:00351073970.804
imaginal disc derived wing margin morphogenesisGO:0008587410.780
positive regulation of macromolecule biosynthetic processGO:00105572830.742
positive regulation of cellular biosynthetic processGO:00313283160.725
positive regulation of rna metabolic processGO:00512542710.725
regionalizationGO:00030024160.696
Zebrafish
positive regulation of macromolecule metabolic processGO:00106044050.684
positive regulation of nucleic acid templated transcriptionGO:19035082660.667
establishment of localization in cellGO:00516494020.666
Zebrafish
male gamete generationGO:00482322010.611
positive regulation of nitrogen compound metabolic processGO:00511733540.604
positive regulation of rna biosynthetic processGO:19026802660.577
posttranscriptional regulation of gene expressionGO:00106081450.573
positive regulation of nucleobase containing compound metabolic processGO:00459353320.564
cell cycle phase transitionGO:00447701400.556
mrna metabolic processGO:00160711240.541
Human Mouse
adult behaviorGO:00305341370.496
positive regulation of transcription dna templatedGO:00458932660.493
negative regulation of nitrogen compound metabolic processGO:00511722650.488
Human Mouse
chromatin organizationGO:00063252070.478
regulation of gene expression epigeneticGO:00400291280.457
intracellular transportGO:00469072280.446
transcription from rna polymerase ii promoterGO:00063663680.397
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.387
macromolecular complex assemblyGO:00650032560.378
Mouse
organelle fissionGO:00482853400.373
negative regulation of cellular biosynthetic processGO:00313272770.352
negative regulation of rna biosynthetic processGO:19026792400.351
regulation of g1 s transition of mitotic cell cycleGO:2000045230.337
sperm individualizationGO:0007291480.320
photoreceptor cell developmentGO:0042461960.305
negative regulation of nucleobase containing compound metabolic processGO:00459342610.299
Human Mouse
asymmetric stem cell divisionGO:0098722490.296
regulation of cell proliferationGO:00421271630.296
Mouse
regulation of cell cycleGO:00517262910.286
dendrite developmentGO:00163582040.280
negative regulation of rna metabolic processGO:00512532510.260
Human Mouse
protein localizationGO:00081042840.259
muscle structure developmentGO:00610612240.254
Human
neural precursor cell proliferationGO:0061351750.246
Mouse
regulation of cell cycle processGO:00105641810.241
single organism cellular localizationGO:19025801800.239
negative regulation of cell cycle phase transitionGO:19019881030.237
regulation of mitotic cell cycleGO:00073461900.236
mrna processingGO:00063971040.234
Human Mouse
negative regulation of mitotic cell cycle phase transitionGO:19019911030.230
negative regulation of transcription dna templatedGO:00458922370.224
mitotic cell cycle phase transitionGO:00447721380.220
dendrite morphogenesisGO:00488131990.219
regulation of nuclear transcribed mrna poly a tail shorteningGO:006021140.217
rna splicingGO:0008380830.216
Human Mouse
tissue morphogenesisGO:00487292970.213
enzyme linked receptor protein signaling pathwayGO:00071671790.212
histone deubiquitinationGO:001657880.210
regulation of cell cycle phase transitionGO:19019871300.207
negative regulation of neuron deathGO:1901215180.204
cellular protein modification processGO:00064644380.203
regulation of nervous system developmentGO:00519602480.196
negative regulation of cellular metabolic processGO:00313243820.196
protein modification processGO:00362114380.196
positive regulation of biosynthetic processGO:00098913160.195
regulation of mitotic cell cycle phase transitionGO:19019901300.183
telencephalon developmentGO:002153720.182
memoryGO:0007613940.181
embryonic morphogenesisGO:00485982060.179
cell cycle g1 s phase transitionGO:0044843310.176
cystoblast divisionGO:0007282100.174
regulation of cellular protein metabolic processGO:00322682430.172
regulation of cell cycle g1 s phase transitionGO:1902806230.168
posttranscriptional gene silencingGO:0016441460.165
single organism intracellular transportGO:19025822070.164
single organism behaviorGO:00447083910.162
negative regulation of nucleic acid templated transcriptionGO:19035072400.159
locomotory behaviorGO:00076261760.158
g1 s transition of mitotic cell cycleGO:0000082310.157
regulation of localizationGO:00328792750.148
Zebrafish
head developmentGO:00603221350.148
cell divisionGO:00513012480.147
negative regulation of apoptotic processGO:0043066630.146
regulation of cell differentiationGO:00455953020.143
Human Rat
anterior posterior pattern specificationGO:00099521360.140
mitotic dna integrity checkpointGO:0044774750.136
neurological system processGO:00508773580.131
gene silencingGO:00164581380.131
immune system processGO:00023763470.129
eye morphogenesisGO:00485922600.129
cell cycle checkpointGO:0000075950.126
cell fate specificationGO:0001708710.126
adult locomotory behaviorGO:0008344760.124
asymmetric cell divisionGO:0008356370.123
regulation of cell developmentGO:00602842150.121
germarium derived female germ line cyst formationGO:0030727420.117
regulation of neurogenesisGO:00507671580.116
synaptic vesicle recyclingGO:0036465280.115
apposition of dorsal and ventral imaginal disc derived wing surfacesGO:0007475150.114
regulation of mrna 3 end processingGO:003144070.114
segmentationGO:00352822070.114
establishment of protein localizationGO:00451841630.110
regulation of neural precursor cell proliferationGO:2000177350.110
Mouse
protein targetingGO:0006605640.110
negative regulation of signal transductionGO:00099682060.108
Zebrafish
growthGO:00400073590.103
protein transportGO:00150311550.102
negative regulation of macromolecule biosynthetic processGO:00105582700.101
negative regulation of cell cycle processGO:00109481090.100
negative regulation of cellular component organizationGO:00511291080.097
cell fate determinationGO:0001709910.097
regulation of organelle organizationGO:00330431960.096
regulation of mrna processingGO:0050684710.093
Human Mouse
negative regulation of mitotic cell cycleGO:00459301090.092
regulation of nuclear transcribed mrna catabolic process deadenylation dependent decayGO:190015140.089
eye photoreceptor cell developmentGO:0042462810.087
rna interferenceGO:0016246270.087
regulation of gene silencingGO:0060968630.085
response to organic substanceGO:00100332840.083
synaptic vesicle endocytosisGO:0048488280.081
rna 3 end processingGO:0031123450.079
rna processingGO:00063961470.078
Human Mouse
histone lysine demethylationGO:007007660.077
regulation of response to stressGO:00801342000.077
regulation of developmental growthGO:00486381740.077
regulation of meiosisGO:004002030.076
cellular protein localizationGO:00346131600.075
establishment of protein localization to organelleGO:0072594620.072
organic substance transportGO:00717022570.070
gene silencing by rnaGO:0031047570.069
organelle localizationGO:00516401480.069
intracellular protein transportGO:00068861040.068
response to oxygen containing compoundGO:19017002000.068
negative regulation of translationGO:0017148280.068
mrna catabolic processGO:0006402330.067
protein import into nucleusGO:0006606510.066
imaginal disc derived leg segmentationGO:0036011260.065
protein localization to nucleusGO:0034504550.065
posttranscriptional gene silencing by rnaGO:0035194450.064
negative regulation of developmental processGO:00510932010.064
Human
ecdysone receptor mediated signaling pathwayGO:0035076110.064
regulation of growthGO:00400082330.064
cognitionGO:00508901410.063
sister chromatid segregationGO:0000819920.062
mucosal immune responseGO:0002385100.062
regulation of multicellular organismal developmentGO:20000264140.061
spindle organizationGO:00070512530.059
imaginal disc derived wing vein specificationGO:0007474480.059
multi organism behaviorGO:00517051750.058
dna damage checkpointGO:0000077780.057
nuclear importGO:0051170510.057
mitotic cell cycle embryonicGO:0045448380.057
protein phosphorylationGO:00064681690.057
regulation of cytoplasmic transportGO:1903649470.056
mitotic cell cycle checkpointGO:0007093880.056
peripheral nervous system developmentGO:0007422520.054
ribonucleoprotein complex assemblyGO:0022618230.053
Mouse
negative regulation of programmed cell deathGO:0043069720.052
mitotic nuclear divisionGO:00070672130.052
circadian behaviorGO:0048512760.052
male courtship behavior veined wing extensionGO:0048065220.051
negative regulation of cellular protein metabolic processGO:0032269850.051
cytoplasmic transportGO:00164821300.051
blastoderm segmentationGO:00073501590.051
protein catabolic processGO:00301631010.050
ribonucleoprotein complex subunit organizationGO:0071826280.050
Mouse
negative regulation of response to stimulusGO:00485852580.049
Zebrafish
macromolecule catabolic processGO:00090571610.048
brain developmentGO:00074201200.048
positive regulation of mitotic cell cycleGO:0045931340.048
dna packagingGO:0006323910.047
endocytosisGO:00068973100.047
sensory organ morphogenesisGO:00905962600.047
negative regulation of organelle organizationGO:0010639560.047
dna integrity checkpointGO:0031570810.046
heart developmentGO:0007507820.046
mitotic dna damage checkpointGO:0044773740.045
regulation of cellular response to stressGO:0080135890.045
enteroendocrine cell differentiationGO:003588310.045
regulation of molecular functionGO:00650092170.045
deathGO:00162652840.043
regulation of mrna catabolic processGO:006101350.043
chromatin modificationGO:00165681470.043
cell proliferationGO:00082832990.043
Mouse
regulation of cellular localizationGO:00603411360.043
Zebrafish
microtubule depolymerizationGO:0007019250.042
spermatocyte divisionGO:0048137130.042
compound eye photoreceptor developmentGO:0042051780.042
cellular macromolecule catabolic processGO:00442651360.042
positive regulation of wnt signaling pathwayGO:0030177250.042
oocyte microtubule cytoskeleton organizationGO:0016325350.042
heparin metabolic processGO:003020240.042
protein importGO:0017038550.041
histone modificationGO:00165701060.041
regulation of protein modification processGO:00313991120.041
eye developmentGO:00016543230.041
developmental growthGO:00485892800.040
eggshell chorion assemblyGO:0007306660.040
protein targeting to nucleusGO:0044744510.039
multicellular organismal agingGO:00102591400.038
chromosome condensationGO:0030261410.038
regulation of intracellular transportGO:0032386640.038
negative regulation of gene expression epigeneticGO:0045814770.038
learning or memoryGO:00076111410.037
epithelial cell differentiationGO:00308553220.037
positive regulation of mitotic cell cycle phase transitionGO:1901992200.037
tube developmentGO:00352952440.037
nuclear divisionGO:00002803320.036
cellular response to abiotic stimulusGO:0071214580.036
negative regulation of protein metabolic processGO:0051248850.035
hemopoiesisGO:0030097460.035
rhythmic processGO:00485111060.035
regulation of protein transportGO:0051223570.035
nucleocytoplasmic transportGO:0006913720.034
nuclear transportGO:0051169720.034
neuroblast proliferationGO:0007405740.033
regulation of bmp signaling pathwayGO:0030510230.033
cellular component disassemblyGO:0022411460.033
regulation of catalytic activityGO:00507901850.032
axis specificationGO:00097981670.031
regulation of multi organism processGO:00439001310.031
Zebrafish
inter male aggressive behaviorGO:0002121600.031
positive regulation of apoptotic signaling pathwayGO:200123540.031
regulation of i kappab kinase nf kappab signalingGO:004312220.031
positive regulation of g2 m transition of mitotic cell cycleGO:001097120.031
translationGO:0006412690.031
regulation of rna splicingGO:0043484690.030
Human Mouse
neuroblast fate determinationGO:0007400120.030
homeostatic processGO:00425921990.029
Zebrafish
pole cell developmentGO:0007277260.029
regulation of protein stabilityGO:0031647430.028
positive regulation of cellular component organizationGO:00511301560.028
negative regulation of neurogenesisGO:0050768530.028
negative regulation of cell cycle g1 s phase transitionGO:1902807130.028
mitotic g2 dna damage checkpointGO:0007095690.028
methylationGO:0032259470.028
negative regulation of g1 s transition of mitotic cell cycleGO:2000134130.028
cellular response to chemical stimulusGO:00708871990.028
protein localization to organelleGO:0033365820.028
cellular response to radiationGO:0071478520.027
camera type eye developmentGO:004301040.027
stem cell differentiationGO:00488631170.027
extrinsic apoptotic signaling pathwayGO:009719110.027
positive regulation of cell cycle g2 m phase transitionGO:190275120.026
renal system developmentGO:0072001720.026
body morphogenesisGO:001017120.026
female germ line cyst formationGO:0048135420.025
single organism catabolic processGO:00447122280.025
meiotic spindle organizationGO:0000212360.025
chromosome organizationGO:00512763600.025
negative regulation of signalingGO:00230572190.025
Zebrafish
g2 dna damage checkpointGO:0031572690.024
regulation of mrna metabolic processGO:1903311720.024
Human Mouse
compound eye photoreceptor cell differentiationGO:00017511400.024
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178650.024
sensory organ precursor cell fate determinationGO:0016360190.024
synapse assemblyGO:00074161430.024
apoptotic process involved in morphogenesisGO:006056130.024
compound eye developmentGO:00487493070.023
negative regulation of cell deathGO:0060548810.023
columnar cuboidal epithelial cell differentiationGO:00020652560.023
aggressive behaviorGO:0002118630.023
digestive tract developmentGO:00485651490.023
positive regulation of response to stimulusGO:00485843230.023
maintenance of gastrointestinal epitheliumGO:003027730.023
Zebrafish
epithelial cell developmentGO:00020642740.023
compound eye morphogenesisGO:00017452490.022
negative regulation of nervous system developmentGO:0051961920.022
vesicle mediated transportGO:00161923810.022
Zebrafish
regulation of neuron differentiationGO:00456641030.022
modification dependent macromolecule catabolic processGO:0043632790.022
positive regulation of cell proliferationGO:0008284470.022
catabolic processGO:00090564090.022
response to organic cyclic compoundGO:0014070890.022
regulation of double strand break repairGO:200077930.022
membrane disassemblyGO:003039740.021
muscle cell differentiationGO:00426921030.021
Human
positive regulation of lipid catabolic processGO:005099610.021
determination of adult lifespanGO:00083401370.021
mitochondrion localizationGO:0051646170.021
negative regulation of protein depolymerizationGO:1901880230.021
cuticle pattern formationGO:0035017270.021
positive regulation of molecular functionGO:00440931360.020
endomembrane system organizationGO:00102561190.020
signal transduction by p53 class mediatorGO:007233160.020
regulation of programmed cell deathGO:00430671520.020
gland developmentGO:00487321910.020
female meiosis iGO:000714480.020
small molecule metabolic processGO:00442813050.020
nuclear body organizationGO:003057560.020
negative regulation of epidermal growth factor receptor signaling pathwayGO:0042059290.020
regulation of protein localization to nucleusGO:1900180290.020
cellular macromolecule localizationGO:00707272200.019
response to sterolGO:0036314340.019
regulation of protein metabolic processGO:00512462560.019
signal transduction in response to dna damageGO:004277030.019
regulation of transferase activityGO:0051338580.019
regulation of catabolic processGO:00098941700.019
imaginal disc growthGO:0007446370.019
male courtship behaviorGO:0008049630.019
sensory neuron axon guidanceGO:009737420.019
sex comb developmentGO:004549880.019
phagocytosisGO:00069092150.019
muscle organ developmentGO:00075171270.018
regulation of apoptotic processGO:00429811300.018
ecdysone mediated induction of salivary gland cell autophagic cell deathGO:0035072120.018
circulatory system processGO:0003013370.018
mitochondrion distributionGO:0048311100.018
mitotic g2 m transition checkpointGO:0044818700.018
positive regulation of cell developmentGO:0010720610.018
negative regulation of cell cycleGO:00457861160.018
negative regulation of erk1 and erk2 cascadeGO:007037330.018
protein modification by small protein conjugation or removalGO:00706471060.018
cell cycle g2 m phase transitionGO:0044839220.018
appendage segmentationGO:0035285260.017
response to external biotic stimulusGO:00432072930.017
stem cell proliferationGO:0072089880.017
rna export from nucleusGO:0006405120.017
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.017
meiotic cell cycle processGO:19030461320.017
multi multicellular organism processGO:00447061230.017
regulation of epithelial cell differentiationGO:003085640.017
positive regulation of multicellular organismal processGO:00512401430.016
regulation of phosphorylationGO:00423251470.016
cellular response to dna damage stimulusGO:00069742230.016
pronuclear migrationGO:003504640.016
response to hypoxiaGO:0001666530.016
nuclear transcribed mrna poly a tail shorteningGO:0000289120.016
negative regulation of meiotic cell cycleGO:005144720.016
embryonic axis specificationGO:00005781070.016
peptidyl threonine phosphorylationGO:001810720.016
positive regulation of signalingGO:00230562430.016
organ growthGO:0035265560.016
mitochondrion organizationGO:0007005650.016
cellular nitrogen compound catabolic processGO:00442701650.016
regulation of synaptic growth at neuromuscular junctionGO:0008582890.016
phosphorylationGO:00163102940.016
positive regulation of organelle organizationGO:0010638650.016
mesoderm formationGO:0001707210.016
cellular response to light stimulusGO:0071482370.016
taxisGO:00423303040.015
chaeta morphogenesisGO:0008407420.015
larval developmentGO:00021641040.015
agingGO:00075681430.015
regulation of protein kinase activityGO:0045859510.015
regulation of nucleocytoplasmic transportGO:0046822350.015
positive regulation of developmental processGO:00510941430.015
somatic stem cell divisionGO:0048103370.015
negative regulation of cell proliferationGO:0008285690.015
morphogenesis of embryonic epitheliumGO:0016331940.015
sperm axoneme assemblyGO:0007288130.015
imaginal disc derived wing vein morphogenesisGO:0008586440.015
response to ecdysoneGO:0035075340.015
apoptotic processGO:00069151590.014
modification dependent protein catabolic processGO:0019941780.014
gliogenesisGO:0042063800.014
negative regulation of epithelial cell migrationGO:001063310.014
meiotic g2 mi transitionGO:000831530.014
embryonic pattern specificationGO:00098801740.014
positive regulation of intracellular transportGO:0032388420.014
oxoacid metabolic processGO:00434361030.014
regulation of cellular response to growth factor stimulusGO:0090287130.014
regulation of transportGO:00510491810.014
Zebrafish
learningGO:0007612750.014
mrna 3 end processingGO:0031124280.014
regulation of dna repairGO:000628250.013
cardiovascular system developmentGO:0072358820.013
muscle cell fate specificationGO:004269470.013
antennal developmentGO:0007469250.013
positive regulation of transportGO:0051050920.013
Zebrafish
meiotic cell cycleGO:00513211710.013
dorsal appendage formationGO:0046843470.013
regulation of kinase activityGO:0043549530.013
response to decreased oxygen levelsGO:0036293580.013
non canonical wnt signaling pathwayGO:003556780.013
negative regulation of neural precursor cell proliferationGO:2000178270.013
cellular macromolecular complex assemblyGO:00346221530.013
Mouse
cell agingGO:000756920.013
centriole assemblyGO:0098534240.013
protein complex biogenesisGO:00702712010.012
regulation of blood circulationGO:1903522210.012
organonitrogen compound metabolic processGO:19015643180.012
spinal cord developmentGO:002151010.012
meiotic cell cycle phase transitionGO:004477140.012
synaptic transmissionGO:00072682880.012
intracellular steroid hormone receptor signaling pathwayGO:0030518120.012
regulation of protein localizationGO:0032880760.012
regulation of cell fate specificationGO:0042659270.012
epithelial cell migration open tracheal systemGO:0007427320.012
smoothened signaling pathwayGO:0007224490.012
anterior posterior axis specificationGO:00099481090.012
positive regulation of multi organism processGO:0043902400.012
Zebrafish
endodermal cell fate commitmentGO:000171130.012
deactivation of rhodopsin mediated signalingGO:0016059170.012
histone h3 k27 methylationGO:007073460.012
dorsal ventral pattern formationGO:00099531330.012
Zebrafish
regulation of compound eye cone cell fate specificationGO:004268240.012
developmental programmed cell deathGO:00106231380.011
retinal ganglion cell axon guidanceGO:0031290120.011
negative regulation of chromosome organizationGO:2001251190.011
positive regulation of phosphorylationGO:0042327870.011
protein ubiquitinationGO:0016567700.011
regulation of cell deathGO:00109411730.011
positive regulation of cell cycle phase transitionGO:1901989200.011
regulation of embryonic developmentGO:0045995680.011
immune system developmentGO:0002520570.011
regulation of intracellular protein transportGO:0033157460.011
axon target recognitionGO:0007412160.011
male meiosisGO:0007140520.011
regulation of phosphorus metabolic processGO:00511742100.011
morphogenesis of an epitheliumGO:00020092760.011
regulation of dendrite morphogenesisGO:0048814280.011
positive regulation of mrna processingGO:005068540.011
camera type eye morphogenesisGO:004859320.011
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161540.011
regulation of cellular response to hypoxiaGO:190003730.011
cellular component assembly involved in morphogenesisGO:00109271510.011
heparan sulfate proteoglycan biosynthetic process polysaccharide chain biosynthetic processGO:001501450.011
neuroblast fate commitmentGO:0014017190.011
mitotic sister chromatid segregationGO:0000070870.011
mesenchymal cell differentiationGO:004876210.011
rhythmic behaviorGO:0007622760.010
regulation of glial cell differentiationGO:004568510.010
response to ketoneGO:1901654340.010
regulation of actin cytoskeleton organizationGO:0032956420.010
g2 m transition of mitotic cell cycleGO:0000086190.010
ubiquitin dependent protein catabolic processGO:0006511780.010
regulation of sister chromatid cohesionGO:000706320.010
regulation of cell morphogenesis involved in differentiationGO:0010769610.010
nucleus organizationGO:0006997450.010

heph disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org