IMP: Integrative Multi-species Prediction

Drosophila melanogaster

0 known processes

LvpH (Dmel_CG8696)

Larval visceral protein H

(Aliases: Dmel\CG8696,H,CG8696,V)

FLYBASE: FBgn0002570
Entrez: 35824
UniProtKB: P07190

Process Predictions
Disease Predictions

LvpH biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
branched chain amino acid transport	GO:0015803	3	0.855	Fly
leucine import	GO:0060356	3	0.821	Fly
phospholipid homeostasis	GO:0055091	1	0.810
phosphatidic acid metabolic process	GO:0046473	1	0.619
oligosaccharide transport	GO:0015772	2	0.611
triglyceride catabolic process	GO:0019433	3	0.569
cholesterol homeostasis	GO:0042632	3	0.495
positive regulation of lipid storage	GO:0010884	4	0.446
ethanolamine containing compound metabolic process	GO:0042439	4	0.429
positive regulation of sequestering of triglyceride	GO:0010890	1	0.408
heparan sulfate proteoglycan metabolic process	GO:0030201	10	0.371
regulation of sterol transport	GO:0032371	1	0.370
disaccharide transport	GO:0015766	2	0.348
response to cold	GO:0009409	13	0.345
cholesterol transport	GO:0030301	2	0.329
alditol phosphate metabolic process	GO:0052646	2	0.315
single organism catabolic process	GO:0044712	228	0.312	Yeast
catabolic process	GO:0009056	409	0.301	Yeast
disaccharide metabolic process	GO:0005984	4	0.291	Yeast
cellular carbohydrate catabolic process	GO:0044275	2	0.272	Yeast
response to temperature stimulus	GO:0009266	106	0.272
appendage morphogenesis	GO:0035107	397	0.269
organic substance transport	GO:0071702	257	0.259	Fly
anion homeostasis	GO:0055081	3	0.251
glycerolipid catabolic process	GO:0046503	3	0.247
phosphatidylethanolamine metabolic process	GO:0046337	1	0.239
immune response	GO:0006955	246	0.222
cellular modified amino acid metabolic process	GO:0006575	45	0.203
regulation of lipid storage	GO:0010883	22	0.187
acylglycerol catabolic process	GO:0046464	3	0.183
neutral lipid biosynthetic process	GO:0046460	2	0.176
neutral lipid catabolic process	GO:0046461	3	0.175
proteoglycan metabolic process	GO:0006029	10	0.172
organic substance catabolic process	GO:1901575	308	0.171	Yeast
carbohydrate catabolic process	GO:0016052	7	0.160	Yeast
maintenance of location	GO:0051235	73	0.157
immune system process	GO:0002376	347	0.148
triglyceride biosynthetic process	GO:0019432	2	0.147
wing disc morphogenesis	GO:0007472	344	0.146
vesicle mediated transport	GO:0016192	381	0.141
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.141
sterol homeostasis	GO:0055092	4	0.137
appendage development	GO:0048736	401	0.137
imaginal disc derived appendage development	GO:0048737	399	0.131
lipid storage	GO:0019915	38	0.120
amino acid transport	GO:0006865	12	0.114	Fly
endocytosis	GO:0006897	310	0.113
response to abiotic stimulus	GO:0009628	341	0.109
gland development	GO:0048732	191	0.106
imaginal disc derived wing morphogenesis	GO:0007476	337	0.105
glycoprotein biosynthetic process	GO:0009101	41	0.104
cation transport	GO:0006812	110	0.104	Fly
macromolecular complex assembly	GO:0065003	256	0.103
defense response	GO:0006952	300	0.103
response to copper ion	GO:0046688	4	0.097
oligosaccharide metabolic process	GO:0009311	18	0.096	Yeast
leucine transport	GO:0015820	3	0.093	Fly
post embryonic appendage morphogenesis	GO:0035120	385	0.093
cellular carbohydrate metabolic process	GO:0044262	22	0.089	Yeast
homeostatic process	GO:0042592	199	0.088
organic hydroxy compound metabolic process	GO:1901615	83	0.087
organonitrogen compound metabolic process	GO:1901564	318	0.087
protein complex biogenesis	GO:0070271	201	0.084
carboxylic acid transport	GO:0046942	18	0.084	Fly
organelle fission	GO:0048285	340	0.083
phagocytosis	GO:0006909	215	0.083
meiosis i	GO:0007127	59	0.080
male meiosis	GO:0007140	52	0.080
small molecule metabolic process	GO:0044281	305	0.079
single organism carbohydrate metabolic process	GO:0044723	72	0.079	Yeast
cellular catabolic process	GO:0044248	372	0.078
protein complex assembly	GO:0006461	200	0.077
acylglycerol biosynthetic process	GO:0046463	2	0.076
anion transport	GO:0006820	41	0.075	Fly
innate immune response	GO:0045087	144	0.074
rhythmic process	GO:0048511	106	0.074
lipid homeostasis	GO:0055088	33	0.073
nitrogen compound transport	GO:0071705	85	0.070	Fly
response to other organism	GO:0051707	293	0.068
amine metabolic process	GO:0009308	12	0.068
carboxylic acid metabolic process	GO:0019752	92	0.068
cellular amino acid metabolic process	GO:0006520	61	0.068
neutral lipid metabolic process	GO:0006638	12	0.067
organic acid transport	GO:0015849	18	0.067	Fly
regulation of transport	GO:0051049	181	0.067
response to external biotic stimulus	GO:0043207	293	0.066
proteoglycan biosynthetic process	GO:0030166	10	0.066
defense response to other organism	GO:0098542	225	0.066
regulation of lipid transport	GO:0032368	3	0.066
regulation of cholesterol transport	GO:0032374	1	0.064
organophosphate metabolic process	GO:0019637	195	0.063
cell proliferation	GO:0008283	299	0.062
positive regulation of signal transduction	GO:0009967	223	0.062
neutral amino acid transport	GO:0015804	6	0.062	Fly
oxoacid metabolic process	GO:0043436	103	0.061
cellular amine metabolic process	GO:0044106	12	0.059
intracellular signal transduction	GO:0035556	300	0.059
response to biotic stimulus	GO:0009607	294	0.055
positive regulation of multicellular organismal process	GO:0051240	143	0.055
amino acid import	GO:0043090	5	0.054	Fly
growth	GO:0040007	359	0.054
trehalose transport	GO:0015771	1	0.050
positive regulation of signaling	GO:0023056	243	0.050
positive regulation of response to stimulus	GO:0048584	323	0.049
carbohydrate metabolic process	GO:0005975	82	0.049	Yeast
regulation of intracellular signal transduction	GO:1902531	236	0.049
response to oxygen containing compound	GO:1901700	200	0.048
carbohydrate derivative biosynthetic process	GO:1901137	85	0.048
meiotic nuclear division	GO:0007126	151	0.048
chemical homeostasis	GO:0048878	92	0.047
carbohydrate derivative metabolic process	GO:1901135	217	0.047
organic anion transport	GO:0015711	28	0.047	Fly
response to extracellular stimulus	GO:0009991	116	0.047
response to peptide hormone	GO:0043434	29	0.046
lipid localization	GO:0010876	54	0.045
cellular response to organic substance	GO:0071310	132	0.044
glycerolipid metabolic process	GO:0046486	34	0.043
response to organic cyclic compound	GO:0014070	89	0.043
sulfur compound metabolic process	GO:0006790	59	0.043
response to bacterium	GO:0009617	198	0.042
triglyceride homeostasis	GO:0070328	18	0.042
single organism biosynthetic process	GO:0044711	206	0.042
response to organic substance	GO:0010033	284	0.042
defense response to gram negative bacterium	GO:0050829	94	0.041
regulation of localization	GO:0032879	275	0.041
organophosphate catabolic process	GO:0046434	112	0.041
lipid catabolic process	GO:0016042	21	0.041
fatty acid biosynthetic process	GO:0006633	6	0.041
death	GO:0016265	284	0.041
response to nutrient levels	GO:0031667	114	0.041
cell death	GO:0008219	279	0.040
acylglycerol homeostasis	GO:0055090	19	0.039
tissue death	GO:0016271	102	0.038
lipid metabolic process	GO:0006629	121	0.038
organic acid metabolic process	GO:0006082	103	0.038
protein modification process	GO:0036211	438	0.036
pigment metabolic process	GO:0042440	84	0.035
negative regulation of response to stimulus	GO:0048585	258	0.033
positive regulation of cell communication	GO:0010647	250	0.033
cellular lipid catabolic process	GO:0044242	16	0.033
cellular biogenic amine metabolic process	GO:0006576	9	0.032
nuclear division	GO:0000280	332	0.032
regulation of sequestering of triglyceride	GO:0010889	3	0.031
response to decreased oxygen levels	GO:0036293	58	0.031
response to lipid	GO:0033993	38	0.030
response to organonitrogen compound	GO:0010243	75	0.029
response to inorganic substance	GO:0010035	44	0.029
developmental programmed cell death	GO:0010623	138	0.029
meiotic cell cycle process	GO:1903046	132	0.028
secondary metabolic process	GO:0019748	75	0.028
response to nitrogen compound	GO:1901698	90	0.028
positive regulation of intracellular signal transduction	GO:1902533	116	0.028
ion transport	GO:0006811	145	0.027	Fly
cellular response to chemical stimulus	GO:0070887	199	0.027
response to oxygen levels	GO:0070482	59	0.027
salivary gland cell autophagic cell death	GO:0035071	83	0.027
regulation of defense response	GO:0031347	102	0.027
regulation of response to stress	GO:0080134	200	0.027
autophagic cell death	GO:0048102	83	0.026
small molecule biosynthetic process	GO:0044283	37	0.026
exocrine system development	GO:0035272	162	0.025
regulation of immune response	GO:0050776	118	0.025
regulation of cellular protein metabolic process	GO:0032268	243	0.025
response to fungus	GO:0009620	50	0.025
regulation of immune system process	GO:0002682	176	0.025
cellular protein modification process	GO:0006464	438	0.025
phosphorylation	GO:0016310	294	0.025
salivary gland development	GO:0007431	162	0.025
circadian rhythm	GO:0007623	105	0.024
regulation of cell cycle	GO:0051726	291	0.024
jak stat cascade	GO:0007259	49	0.024
phosphatidylcholine metabolic process	GO:0046470	3	0.024
positive regulation of transport	GO:0051050	92	0.024
triglyceride metabolic process	GO:0006641	12	0.023
epithelial cell differentiation	GO:0030855	322	0.022
response to wounding	GO:0009611	94	0.022
monocarboxylic acid transport	GO:0015718	3	0.022
glycoprotein metabolic process	GO:0009100	41	0.022
salivary gland morphogenesis	GO:0007435	145	0.022
programmed cell death	GO:0012501	257	0.021
camera type eye development	GO:0043010	4	0.021
phenol containing compound metabolic process	GO:0018958	57	0.021
regulation of organelle organization	GO:0033043	196	0.021
pigment biosynthetic process	GO:0046148	36	0.021
compound eye development	GO:0048749	307	0.021
monocarboxylic acid biosynthetic process	GO:0072330	7	0.020
heparan sulfate proteoglycan biosynthetic process	GO:0015012	10	0.020
fatty acid metabolic process	GO:0006631	20	0.020
morphogenesis of an epithelium	GO:0002009	276	0.020
immune response activating signal transduction	GO:0002757	2	0.020
gland morphogenesis	GO:0022612	145	0.020
immune effector process	GO:0002252	98	0.020
proteolysis	GO:0006508	192	0.020
regulation of protein metabolic process	GO:0051246	256	0.020
response to monosaccharide	GO:0034284	4	0.019
pigmentation	GO:0043473	75	0.019
regulation of multicellular organismal development	GO:2000026	414	0.019
response to transition metal nanoparticle	GO:1990267	9	0.019
regulation of cellular ketone metabolic process	GO:0010565	3	0.018
regulation of cellular catabolic process	GO:0031329	157	0.018
regulation of anatomical structure size	GO:0090066	163	0.018
developmental growth	GO:0048589	280	0.018
cellular ketone metabolic process	GO:0042180	24	0.018
response to acid chemical	GO:0001101	25	0.018
regulation of molecular function	GO:0065009	217	0.018
salivary gland histolysis	GO:0035070	88	0.017
positive regulation of macromolecule metabolic process	GO:0010604	405	0.017
cellularization	GO:0007349	90	0.017
response to peptide	GO:1901652	29	0.017
body morphogenesis	GO:0010171	2	0.017
lipid biosynthetic process	GO:0008610	46	0.017
regulation of catalytic activity	GO:0050790	185	0.017
organonitrogen compound catabolic process	GO:1901565	128	0.017
cellular lipid metabolic process	GO:0044255	83	0.017
regulation of catabolic process	GO:0009894	170	0.016
spermatogenesis	GO:0007283	200	0.016
meiotic cell cycle	GO:0051321	171	0.016
embryonic development via the syncytial blastoderm	GO:0001700	148	0.016
ovarian follicle cell development	GO:0030707	248	0.016
regulation of cell death	GO:0010941	173	0.016
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.016
immune response regulating signaling pathway	GO:0002764	2	0.016
positive regulation of biosynthetic process	GO:0009891	316	0.016
melanin metabolic process	GO:0006582	47	0.016
carboxylic acid biosynthetic process	GO:0046394	15	0.016
cell division	GO:0051301	248	0.016
apoptotic process	GO:0006915	159	0.015
regulation of cell development	GO:0060284	215	0.015
negative regulation of cellular metabolic process	GO:0031324	382	0.015
single organism carbohydrate catabolic process	GO:0044724	7	0.015	Yeast
positive regulation of cellular biosynthetic process	GO:0031328	316	0.015
regulation of cell differentiation	GO:0045595	302	0.015
sulfur compound biosynthetic process	GO:0044272	16	0.015
regulation of cellular amine metabolic process	GO:0033238	3	0.015
cellular response to endogenous stimulus	GO:0071495	80	0.015
autophagy	GO:0006914	108	0.015
regulation of phosphorus metabolic process	GO:0051174	210	0.015
response to endogenous stimulus	GO:0009719	119	0.014
negative regulation of cell communication	GO:0010648	223	0.014
pigment metabolic process involved in pigmentation	GO:0043474	33	0.014
male meiosis i	GO:0007141	9	0.014
response to calcium ion	GO:0051592	1	0.014
cell recognition	GO:0008037	102	0.014
activation of innate immune response	GO:0002218	4	0.014
negative regulation of gene expression	GO:0010629	387	0.014
developmental pigmentation	GO:0048066	68	0.014
ocellus pigmentation	GO:0033060	19	0.014
regulation of response to external stimulus	GO:0032101	115	0.014
lauric acid metabolic process	GO:0048252	1	0.014
cell migration	GO:0016477	238	0.014
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.014
cellular nitrogen compound catabolic process	GO:0044270	165	0.014
histolysis	GO:0007559	102	0.014
organic acid biosynthetic process	GO:0016053	15	0.014
regulation of anatomical structure morphogenesis	GO:0022603	242	0.013
regulation of innate immune response	GO:0045088	71	0.013
response to hormone	GO:0009725	45	0.013
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.013
dendrite morphogenesis	GO:0048813	199	0.013
negative regulation of signaling	GO:0023057	219	0.013
macromolecule catabolic process	GO:0009057	161	0.013
response to organophosphorus	GO:0046683	2	0.013
acylglycerol metabolic process	GO:0006639	12	0.013
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.013
regulation of cellular amino acid metabolic process	GO:0006521	0	0.013
gene silencing	GO:0016458	138	0.012
response to lipopolysaccharide	GO:0032496	4	0.012
forebrain development	GO:0030900	2	0.012
positive regulation of gene expression	GO:0010628	290	0.012
cellular response to hormone stimulus	GO:0032870	44	0.012
phospholipid metabolic process	GO:0006644	23	0.012
regulation of programmed cell death	GO:0043067	152	0.012
glycerophospholipid metabolic process	GO:0006650	23	0.012
aging	GO:0007568	143	0.012
regulation of apoptotic process	GO:0042981	130	0.012
small gtpase mediated signal transduction	GO:0007264	88	0.012
localization of cell	GO:0051674	257	0.012
telencephalon development	GO:0021537	2	0.012
innate immune response activating signal transduction	GO:0002758	2	0.012
response to radiation	GO:0009314	155	0.012
mapk cascade	GO:0000165	107	0.012
negative regulation of signal transduction	GO:0009968	206	0.012
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.012
tissue morphogenesis	GO:0048729	297	0.012
epithelial cell development	GO:0002064	274	0.012
acetylcholine metabolic process	GO:0008291	2	0.012
negative regulation of immune system process	GO:0002683	50	0.012
defense response to gram positive bacterium	GO:0050830	41	0.012
embryo development ending in birth or egg hatching	GO:0009792	152	0.012
positive regulation of protein metabolic process	GO:0051247	128	0.012
positive regulation of cell migration	GO:0030335	2	0.012
pigment metabolic process involved in developmental pigmentation	GO:0043324	33	0.012
steroid catabolic process	GO:0006706	1	0.011
morphogenesis of a polarized epithelium	GO:0001738	93	0.011
ion homeostasis	GO:0050801	55	0.011
dendrite development	GO:0016358	204	0.011
axon development	GO:0061564	297	0.011
multicellular organismal aging	GO:0010259	140	0.011
rna localization	GO:0006403	115	0.011
cellular response to biotic stimulus	GO:0071216	4	0.011
developmental maturation	GO:0021700	172	0.011
open tracheal system development	GO:0007424	204	0.011
protein heterooligomerization	GO:0051291	4	0.011
response to hexose	GO:0009746	3	0.011
kidney development	GO:0001822	3	0.011
signal transduction by phosphorylation	GO:0023014	107	0.011
defense response to bacterium	GO:0042742	178	0.011
positive regulation of cell motility	GO:2000147	3	0.011
fertilization	GO:0009566	26	0.011
humoral immune response	GO:0006959	117	0.011
regulation of notch signaling pathway	GO:0008593	100	0.011
regionalization	GO:0003002	416	0.011
positive regulation of catalytic activity	GO:0043085	118	0.011
eye pigmentation	GO:0048069	43	0.011
positive regulation of cellular amine metabolic process	GO:0033240	0	0.011
positive regulation of molecular function	GO:0044093	136	0.011
cellular macromolecule catabolic process	GO:0044265	136	0.011
aromatic compound catabolic process	GO:0019439	166	0.011
monocarboxylic acid metabolic process	GO:0032787	29	0.010
sensory organ morphogenesis	GO:0090596	260	0.010
mitotic nuclear division	GO:0007067	213	0.010
protein phosphorylation	GO:0006468	169	0.010
purine nucleotide metabolic process	GO:0006163	146	0.010
organic cyclic compound catabolic process	GO:1901361	168	0.010
alcohol metabolic process	GO:0006066	25	0.010
hindbrain development	GO:0030902	2	0.010
nucleotide metabolic process	GO:0009117	161	0.010
positive regulation of cellular component organization	GO:0051130	156	0.010
single organism intracellular transport	GO:1902582	207	0.010
synaptic transmission	GO:0007268	288	0.010
response to drug	GO:0042493	17	0.010

LvpH disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
familial hyperlipidemia	DOID:1168	0.836
disease of metabolism	DOID:0014667	0.836
lipid metabolism disorder	DOID:3146	0.836
familial lipoprotein lipase deficiency	DOID:14118	0.836
inherited metabolic disorder	DOID:655	0.836
familial combined hyperlipidemia	DOID:13809	0.765
disease of anatomical entity	DOID:7	0.646
hair disease	DOID:421	0.646
hypotrichosis	DOID:4535	0.646
integumentary system disease	DOID:16	0.646
familial hypertriglyceridemia	DOID:0050527	0.298
acquired metabolic disease	DOID:0060158	0.292
carbohydrate metabolism disease	DOID:0050013	0.181
diabetes mellitus	DOID:9351	0.181
type 2 diabetes mellitus	DOID:9352	0.181
glucose metabolism disease	DOID:4194	0.181
nervous system disease	DOID:863	0.015
cardiovascular system disease	DOID:1287	0.013

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